GO-CAM Receptor Animation Gallery Prototype

Sixteen receptor-centered animation sketches for ligand binding, membrane-spanning conformational change, cytosolic-side activation, adaptor recruitment, post-translational modification, cell-cell signaling, cytokine signaling, Notch cleavage, ciliary signaling, death receptor signaling, integrin adhesion, intracellular pattern recognition, and synaptic scaffolding. These are presentation prototypes; the next step is to regenerate the labels and edges from Barista model exports.

Model export is currently blocked by a bad BARISTA_TOKEN. Model IDs and production titles are included so the gallery can be rewired to exported GO-CAM YAML once a fresh token is available.
gomodel:69ea894900000468

Activation of OXGR1 by 2-oxoglutarate via G-alpha-q signaling

A GPCR cartoon: extracellular ligand docks, transmembrane helices shift, and the cytosolic face recruits G-alpha-q.

2-oxoglutarateOXGR1cytosolic openingG-alpha-qIP3 / DAG
bind7TM shiftGq dockIP3/DAG
Animated OXGR1 receptor mechanism sketch 2-oxoglutarate binds the extracellular side of OXGR1, the receptor changes conformation through the membrane, and G-alpha-q docks on the cytosolic side. extracellular cytosol 2-OG ligand pocket 1 2 3 4 5 6 7 OXGR1 7TM G-alpha-q docks IP3 DAG ligand-bound receptor exposes cytosolic site 1
gomodel:67369e7600001410

Acetylcholine-gated CHRNA7/CHRNB2 receptor and calcium transport

A ligand-gated channel cartoon: acetylcholine binds outside, the pore opens across the membrane, and calcium enters the cytosol.

acetylcholineCHRNA7/CHRNB2open poreCa2+ influxcytosolic calcium
ACh bindgate opensCa2+ fluxresponse
Animated CHRNA7 channel mechanism sketch Acetylcholine binds the extracellular side of a CHRNA7 and CHRNB2 receptor complex, the channel gate opens, and calcium ions move into the cytosol. extracellular cytosol ACh sites ion pore CHRNA7/CHRNB2 Ca2+ cytosolic rise cell response binding opens the transmembrane pore 2
gomodel:69ea894900000425

OR51E2 olfactory signaling after activation by propionate

A sensory GPCR cartoon: propionate binds the extracellular pocket, the receptor rearranges, and G-alpha-olf engages in the cytosol.

propionateOR51E2cytosolic openingG-alpha-olfADCY / cAMP
odorant7TM shiftGolf dockcAMP
Animated OR51E2 receptor mechanism sketch Propionate binds OR51E2, causing a transmembrane conformational change and cytosolic G-alpha-olf engagement. extracellular cytosol propionate odorant pocket OR51E2 G-alpha-olf docks ADCY cAMP odorant-bound receptor activates G protein 3
gomodel:66b5638000001772

Calcitonin ligand activating CALCR receptor

A hormone receptor cartoon: calcitonin binds the extracellular face, CALCR changes shape, and the cytosolic side initiates signaling.

CALCA/CTCALCRcytosolic openingsignal relaycell response
peptide bindECD closescytosol opensresponse
Animated CALCR receptor mechanism sketch Calcitonin binds CALCR outside the cell, the receptor changes conformation through the membrane, and cytosolic signaling begins. extracellular cytosol CALCA/CT peptide CALCR extracellular domain 7TM core signal relay cell response hormone binding opens cytosolic face 4
gomodel:62b4ffe300004795

Insulin receptor signaling pathway

A receptor tyrosine kinase archetype: insulin brings receptor halves together, cytosolic tails phosphorylate, and IRS signaling docks.

insulinINSR dimerphosphorylationIRS dockingPI3K/AKT
insulindimerizepY sitesIRS dock
Animated insulin receptor dimerization sketch Insulin binds extracellular receptor domains, INSR dimerizes, cytosolic tyrosine sites are phosphorylated, and IRS docks. extracellular cytosol insulin INSR IRS docks PI3K AKT dimerization exposes phosphotyrosine docking sites 5
gomodel:6413ac9800000256

MYD88-dependent TLR4 signaling leading to autophagy activation

An innate immune adaptor archetype: ligand-bound TLR4 exposes a cytosolic TIR surface and recruits MYD88 to launch downstream signaling.

LPS-like ligandTLR4TIR surfaceMYD88autophagy
ligandTIR opensMYD88signal
Animated TLR4 adaptor recruitment sketch A ligand binds TLR4 outside the cell, a cytosolic TIR site is exposed, MYD88 docks, and downstream autophagy signaling is activated. extracellular cytosol LPS TLR4 ectodomain TIR MYD88 adaptor autophagy activation ligand-bound TLR4 recruits a cytosolic adaptor 6
gomodel:69d8496c00001257

Activation of cGAS-STING signaling following STING1 ubiquitination by TRIM69

A post-translational activation archetype: TRIM69 places ubiquitin on STING1 at the membrane, creating an active signaling state.

TRIM69ubiquitinSTING1TBK1IFN response
E3 engagesubiquitinSTING activeTBK1
Animated STING ubiquitination sketch TRIM69 transfers ubiquitin marks to STING1 at a membrane, activating downstream cGAS-STING signaling. cytosol ER / signaling membrane TRIM69 E3 ligase STING1 TBK1 kinase IFN response ubiquitin marks switch STING1 into an active scaffold 7
gomodel:685de18700003315

Stimulation of T cell receptor signaling by CD28 following binding to CD80

A cell-cell contact archetype: CD80 on an antigen-presenting cell engages CD28 on a T cell and triggers cytosolic costimulatory signaling.

CD80CD28cell contactcostimulationTCR signal
contactCD80/CD28costimT cell
Animated CD28 costimulation sketch An antigen-presenting cell contacts a T cell; CD80 binds CD28 and a costimulatory signal propagates into the T cell. antigen-presenting cell T cell cytosol CD80 APC CD28 T cell tail TCR boost cell-cell ligand/receptor contact triggers costimulation 8
gomodel:66e382fb00001606

Hepcidin induction by BMP6 signaling

A serine/threonine kinase receptor archetype: BMP6 bridges receptor subunits, cytosolic kinase domains activate, and SMAD carries the signal toward transcription.

BMP6type I/II receptorkinase domainsSMADhepcidin
BMP6 bindreceptor pairSMADtranscribe
Animated BMP6 receptor signaling sketch BMP6 binds a pair of membrane receptors, activating cytosolic kinase domains and SMAD-mediated transcriptional output. extracellular cytosol BMP6 BMP receptor SMAD activated HAMP hepcidin BMP6 promotes receptor pairing and SMAD activation 9
gomodel:6205c24300001663

IL2 signaling pathway

A cytokine receptor/JAK-STAT archetype: IL2 binds a receptor complex, paired JAK kinases activate, and STAT moves toward the nucleus.

IL2IL2 receptorJAKSTATtranscription
IL2 bindJAK activeSTATnucleus
Animated IL2 cytokine receptor signaling sketch IL2 binds a receptor complex, activating cytosolic JAK kinases and STAT-dependent transcriptional signaling. extracellular cytosol IL2 IL2R receptor complex STAT docks gene response cytokine binding activates receptor-associated JAKs 10
gomodel:60ad85f700000309

Notch signaling pathway via N-Dl

A juxtacrine receptor archetype: Delta on a neighboring cell pulls on Notch, releasing an intracellular fragment that travels to the nucleus.

DeltaNotchcleavageNICDnucleus
contactpullcleaveNICD
Animated Notch juxtacrine signaling sketch Delta ligand on one cell contacts Notch on another cell, triggering receptor cleavage and movement of the Notch intracellular domain toward the nucleus. Delta-expressing cell Notch cell cytosol Delta Dl Notch NICD CSL targets ligand pulling releases the intracellular Notch fragment 11
gomodel:6516135700000284

Hedgehog signaling in oligodendrocyte maintenance enabled by BOC

A primary-cilium signaling archetype: Hedgehog binds BOC/PTCH-associated receptors, SMO shifts in the cilium, and GLI output changes.

HedgehogBOC/PTCHprimary ciliumSMOGLI
Hh bindSMO shiftGLIoutput
Animated Hedgehog ciliary signaling sketch Hedgehog ligand binds a receptor complex at the primary cilium, SMO shifts in the cilium, and GLI signaling output is activated. extracellular cell body / cytosol Hh BOC PTCH SMO GLI output cell state ligand-bound receptor complex changes ciliary SMO signaling 12
gomodel:663d668500001551

FASL-FAS interaction leading to apoptosis

A death receptor archetype: trimeric FASL clusters FAS, the cytosolic death domains assemble a DISC-like complex, and caspase signaling drives apoptotic output.

FASLFASdeath domainFADD/CASP8apoptosis
FASL bindclusterDISCcaspase
Animated FAS death receptor signaling sketch FASL binds and clusters FAS receptors, cytosolic death domains recruit FADD and CASP8, and apoptotic signaling is activated. extracellular cytosol FASL FAS death receptors FADD CASP8 apoptosis program ligand clustering exposes cytosolic death-domain sites 13
gomodel:645d887900000439

FN1 activates liver autophagy via Itga5:Itgb1 integrin signaling

An adhesion receptor archetype: extracellular fibronectin engages an integrin pair, cytosolic adaptor tension accumulates, and the downstream state points toward autophagy.

FN1Itga5:Itgb1integrin clusteradaptorautophagy
FN1 bindclusteradaptorautophagy
Animated fibronectin integrin signaling sketch FN1 fibers bind an Itga5:Itgb1 integrin pair, receptor legs cluster across the membrane, and a cytosolic adaptor signal leads toward autophagy. extracellular matrix hepatocyte cytosol FN1 Itga5:Itgb1 integrin pair talin adaptor autophagy state matrix ligand engagement clusters integrin cytosolic tails 14
gomodel:641ce4dc00000050

NOD2 response to muramyl dipeptide

An intracellular pattern-recognition archetype: MDP appears in the cytosol, NOD2 oligomerizes, RIPK2 docks, and NF-kappa-B/MAPK outputs are activated.

MDPNOD2oligomerRIPK2NF-kappa-B/MAPK
MDP senseNOD2 clusterRIPK2output
Animated NOD2 cytosolic signaling sketch Muramyl dipeptide in the cytosol is sensed by NOD2, which clusters and recruits RIPK2 to drive NF-kappa-B and MAPK signaling. cytosol MDP NOD2 NOD2 NOD2 oligomer RIPK2 docks MAPK kinase NF-kB output cytosolic bacterial fragment sensing builds a signaling hub 15
gomodel:66b5638000002885

NRXN1B-CBLN2-GRID1 trans-synaptic complex regulates NMDAR signaling

A synaptic scaffolding archetype: presynaptic NRXN1B, cleft CBLN2, and postsynaptic GRID1 form a bridge that coordinates NMDAR-side signaling.

NRXN1BCBLN2GRID1NMDARsynaptic signal
bridgealignGRID1NMDAR
Animated trans-synaptic receptor scaffold sketch NRXN1B on the presynaptic side, CBLN2 in the synaptic cleft, and GRID1 on the postsynaptic side form a bridge that regulates NMDAR signaling. presynaptic cell synaptic cleft postsynaptic cell NRXN1B CBLN2 GRID1 NMDAR synaptic output trans-synaptic scaffold aligns receptors across the cleft 16