go-ontology

Ontology comparison

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Ontology IRI: http://purl.obolibrary.org/obo/go/extensions/go-plus.ofn
Version IRI: http://purl.obolibrary.org/obo/go/releases/2026-03-25/extensions/go-plus.ofn
Loaded from: file:/__w/go-ontology/go-ontology/src/ontology/go-plus-lastrelease.owl

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Ontology IRI: http://purl.obolibrary.org/obo/go/extensions/go-plus.ofn
Version IRI: http://purl.obolibrary.org/obo/go/releases/2026-05-12/extensions/go-plus.ofn
Loaded from: file:/__w/go-ontology/go-ontology/src/ontology/extensions/go-plus.ofn

versionInfo “2026-03-25”

versionInfo “2026-05-12”

(R)-2-hydroxyisocaproate dehydrogenase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31966”^^anyURI
(R)-2-hydroxyisocaproate dehydrogenase activity term replaced by (2R)-2-hydroxyacid dehydrogenase (NAD+) activity
(R)-2-hydroxyisocaproate dehydrogenase activity definition “OBSOLETE. Catalysis of the reaction: 2-oxoisocaproate + NADH + H+ = (R)-2-hydroxyisocaproate + NAD+.”
- has cross-reference “PMID:16957230”
- has cross-reference “GOC:jl”
(R)-2-hydroxyisocaproate dehydrogenase activity deprecated true
(R)-2-hydroxyisocaproate dehydrogenase activity comment “The reason for obsoletion is that this term is equivalent to GO:0140175 (2R)-2-hydroxyacid dehydrogenase (NAD+) activity. "(R)-2-hydroxyisocaproate dehydrogenase" is a synonym of EC:1.1.1.345 (D-2-hydroxyacid dehydrogenase (NAD+)), which is the exact match xref of GO:0140175. The reaction catalyzed (involving (R)-2-hydroxy-4-methylpentanoate / 2-oxoisocaproate, RHEA:10052) is a narrowMatch instance of the more general reaction in GO:0140175.”
(R)-2-hydroxyisocaproate dehydrogenase activity label “obsolete (R)-2-hydroxyisocaproate dehydrogenase activity”

(R)-sulfopropanediol 2-dehydrogenase activity has cross-reference “MetaCyc:RXN-11729”
(R)-sulfopropanediol 2-dehydrogenase activity definition “Catalysis of the reaction: (2R)-3-sulfopropanediol(1-) + NAD = 2-oxo-3-hydroxy-propane-1-sulfonate + NADH + H+.”
- has cross-reference “PMID:20150239”
- has cross-reference “GOC:pz”
(R)-sulfopropanediol 2-dehydrogenase activity label “(R)-sulfopropanediol 2-dehydrogenase activity”

1,8-cineole synthase activity definition “Catalysis of the reaction: geranyl diphosphate(3-) + H2O = 1,8-cineole + diphosphoric acid.”
- has cross-reference “GOC:pz”
- has cross-reference “RHEA:32543”

1,8-cineole synthase activity definition “Catalysis of the reaction: geranyl diphosphate(3-) + H2O = 1,8-cineole + diphosphoric acid.”
- has cross-reference “RHEA:32543”

2,5-dioxovalerate dehydrogenase (NADP+) activity definition “Catalysis of the reaction: 2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + H+.”
- has cross-reference “EC:1.2.1.26”
- has cross-reference “MetaCyc:25-DIOXOVALERATE-DEHYDROGENASE-RXN”

2,5-dioxovalerate dehydrogenase (NADP+) activity definition “Catalysis of the reaction: 2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + H+.”
- has cross-reference “RHEA:11296”

2-aminobenzenesulfonate 2,3-dioxygenase activity definition “Catalysis of the reaction: 2-aminobenzenesulfonate + 2 H+ + NADH + O2 = 2,3-dihydroxybenzenesulfonate + NAD+ + NH4. 2,3-dihydroxybenzenesulfonate is also known as 3-sulfocatechol.”
- has cross-reference “EC:1.14.12.14”
- has cross-reference “RHEA:23468”

2-aminobenzenesulfonate 2,3-dioxygenase activity definition “Catalysis of the reaction: 2-aminobenzenesulfonate + 2 H+ + NADH + O2 = 2,3-dihydroxybenzenesulfonate + NAD+ + NH4. 2,3-dihydroxybenzenesulfonate is also known as 3-sulfocatechol.”
- has cross-reference “RHEA:23468”

2-hydroxyisocaproate CoA-transferase activity has exact synonym “(R)-2-hydroxyisocaproate CoA-transferase activity”
2-hydroxyisocaproate CoA-transferase activity definition “Catalysis of the reaction: (R)-2-hydroxyisocaproate + isocaproyl-CoA = (R)-2-hydroxyisocaproyl-CoA + isocaproate.”
- has cross-reference “PMID:16957230”
2-hydroxyisocaproate CoA-transferase activity label “2-hydroxyisocaproate CoA-transferase activity”

2-hydroxyquinoline 5,6-dioxygenase activity definition “Catalysis of the reaction: quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+.”
- has cross-reference “EC:1.14.12.16”

2-hydroxyquinoline 5,6-dioxygenase activity definition “Catalysis of the reaction: quinolin-2-ol + NADH + O2 + H+ = 5,6-dihydroquinoline-2,5,6-triol + NAD+.”
- has cross-reference “RHEA:10976”

3-butenylglucosinolate 2-hydroxylase activity definition “Catalysis of the reaction: gluconapin + a reduced electron acceptor + O2 = xi-progoitrin + an oxidized electron acceptor + H2O.”
- has cross-reference “PMID:18945935”

3-butenylglucosinolate 2-hydroxylase activity definition “Catalysis of the reaction: gluconapin + a reduced electron acceptor + O2 = progoitrin + an oxidized electron acceptor + H2O.”
- has cross-reference “PMID:18945935”
- has cross-reference “RHEA:60628”

3-chlorobenzoate-3,4-oxygenase activity definition “Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor = 3-chlorobenzoate-cis-3,4-diol + an oxidized electron acceptor.”
- has cross-reference “PMID:8285670”
- has cross-reference “GOC:pz”

3-chlorobenzoate-3,4-oxygenase activity definition “Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor = 3-chlorobenzoate-cis-3,4-diol + an oxidized electron acceptor.”
- has cross-reference “PMID:38488372”
- has cross-reference “PMID:8285670”

3-oxoadipate CoA-transferase activity definition “Catalysis of the reaction: succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA.”
- has cross-reference “MetaCyc:3-OXOADIPATE-COA-TRANSFERASE-RXN”
- has cross-reference “EC:2.8.3.6”

3-oxoadipate CoA-transferase activity definition “Catalysis of the reaction: 3-oxoadipate + succinyl-CoA = 3-oxoadipyl-CoA + succinate.”
- has cross-reference “RHEA:12048”

3-phenylpropionate dioxygenase activity definition “Catalysis of the reaction: 3-phenylpropionate + NADH + H+ + O2 = NAD+ + cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol.”
- has cross-reference “UM-BBD_enzymeID:e0307”

3-phenylpropionate dioxygenase activity definition “Catalysis of the reaction: 3-phenylpropanoate + NADH + O2 + H+ = 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+.”
- has cross-reference “RHEA:20357”

4-O-methyl-glucuronoyl methylesterase activity definition “Catalysis of the reaction: [X]-4-O-methyl-D-glucuronic acid + H2O = [X]-OH + methyl-D-glucuronic acid. This reaction is the hydrolysis of the ester linkage between 4-O-methyl-D-glucuronic acid (MeGlcA) and an alcohol (-OH) group attached to a molecule, denoted here as [X].”
- has cross-reference “PMID:16876163”
- has cross-reference “GOC:mengo_curators”

4-aminobenzoate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of 4-aminobenzoate, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins.”
- has cross-reference “MetaCyc:PWY-6543”
- has cross-reference “ISBN:0198506732”
- has cross-reference “PMID:11377864”
- has cross-reference “PMID:11960743”
4-aminobenzoate biosynthetic process SubClassOf para-aminobenzoic acid metabolic process

4-aminobenzoate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of 4-aminobenzoate, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins.”
- has cross-reference “MetaCyc:PWY-6543”
- has cross-reference “PMID:11377864”
- has cross-reference “PMID:11960743”
4-aminobenzoate biosynthetic process SubClassOf benzene-containing compound metabolic process

4-chlorophenylacetate 3,4-dioxygenase activity definition “Catalysis of the reaction: 4-chlorophenylacetate + NADH + O2 = 3,4-dihydroxyphenylacetate + chloride + NAD+.”
- has cross-reference “RHEA:14689”
- has cross-reference “EC:1.14.12.9”

4-chlorophenylacetate 3,4-dioxygenase activity definition “Catalysis of the reaction: 4-chlorophenylacetate + NADH + O2 = 3,4-dihydroxyphenylacetate + chloride + NAD+.”
- has cross-reference “RHEA:14689”

4-hydroxybenzoyl-CoA reductase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31969”^^anyURI
4-hydroxybenzoyl-CoA reductase activity definition “Catalysis of the reaction: oxidized 2[4Fe-4S]-[ferredoxin] + benzoyl-CoA + H2O = 4-hydroxybenzoyl-CoA + reduced 2[4Fe-4S]-[ferredoxin] + 2 H+.”
- has cross-reference “RHEA:29603”
4-hydroxybenzoyl-CoA reductase activity SubClassOf oxidoreductase activity, acting on CH-OH group of donors

4-hydroxybutanoyl-CoA dehydratase activity definition “Catalysis of the reaction: 4-hydroxybutanoyl-CoA = vinylacetyl-CoA + H2O.”
- has cross-reference “EC:4.2.1.120”

4-hydroxybutanoyl-CoA dehydratase activity definition “Catalysis of the reaction: 4-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O.”
- has cross-reference “RHEA:26530”

4-hydroxybutyrate CoA-transferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31862”^^anyURI
4-hydroxybutyrate CoA-transferase activity term replaced by 4-hydroxybutanoyl-CoA dehydratase activity
4-hydroxybutyrate CoA-transferase activity definition “OBSOLETE. Catalysis of the transfer of a coenzyme A (CoA) group to 4-hydroxybutyrate.”
- has cross-reference “PMID:25452282”
- has cross-reference “GOC:jl”
4-hydroxybutyrate CoA-transferase activity deprecated true
4-hydroxybutyrate CoA-transferase activity comment “This term was obsoleted because it represents the same activity as 4-hydroxybutanoyl-CoA dehydratase activity ; GO:0043721. The term was incorrectly defined; the paper cited describes dehydration of 4-hydroxybutyryl-CoA to crotonyl-CoA ((2E)-butenoyl-CoA).”
4-hydroxybutyrate CoA-transferase activity label “obsolete 4-hydroxybutyrate CoA-transferase activity”

4-hydroxycatechol 1,2-dioxygenase activity label “4-hydroxycatechol 1,2-dioxygenase activity”

4-sulfobenzoate 3,4-dioxygenase activity definition “Catalysis of the reaction: 4-sulfobenzoate + H+ + NADH + O2 = 3,4-dihydroxybenzoate + NAD+ + sulfite.”
- has cross-reference “EC:1.14.12.8”
- has cross-reference “RHEA:13937”

4-sulfobenzoate 3,4-dioxygenase activity definition “Catalysis of the reaction: 4-sulfobenzoate + H+ + NADH + O2 = 3,4-dihydroxybenzoate + NAD+ + sulfite.”
- has cross-reference “RHEA:13937”

5’-nucleotidase activity exactMatch 12484
5’-nucleotidase activity definition “Catalysis of the reaction: a 5’-ribonucleotide + H2O = a ribonucleoside + phosphate.”
- has cross-reference “EC:3.1.3.5”
5’-nucleotidase activity has_related_synonym “5’-ribonucleotide phosphohydrolase activity”
- has cross-reference “EC:3.1.3.5”

5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity definition “Catalysis of the reaction: 5-HETE + NADP+ = 5-oxo-ETE + NADPH + H+.”
- has cross-reference “GOC:mw”
- has cross-reference “PMID:1326548”

5-hydroxypentanoate CoA-transferase activity definition “Catalysis of the reaction: 5-hydroxypentanoate + acetyl-CoA = 5-hydroxy-pentanoyl-CoA + acetate.”
- has cross-reference “RHEA:23496”
- has cross-reference “EC:2.8.3.14”

5-hydroxypentanoate CoA-transferase activity definition “Catalysis of the reaction: 5-hydroxypentanoate + acetyl-CoA = 5-hydroxy-pentanoyl-CoA + acetate.”
- has cross-reference “RHEA:23496”

5-phosphoribose 1-diphosphate biosynthetic process has cross-reference “Reactome:R-HSA-73843”
- label “5-Phosphoribose 1-diphosphate biosynthesis”

7,8-dihydro-D-neopterin 2’,3’-cyclic phosphate phosphodiesterase activity definition “Catalysis of the reaction: 7,8-dihydro-D-neopterin 2’,3’-cyclic phosphate + H2O = 7,8-dihydroneopterin 3’-phosphate + H+.”
- has cross-reference “PMID:19746965”
- has cross-reference “GOC:mengo_curators”

ADP-ribosylarginine hydrolase activity label “ADP-ribosylarginine hydrolase activity”

ADP-ribosylglutamate hydrolase activity definition “Catalysis of the reaction: (ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = L-glutamyl-[protein] + ADP-ribose.”
- has cross-reference “PMID:23481255”
ADP-ribosylglutamate hydrolase activity label “ADP-ribosylglutamate hydrolase activity”

ADP-ribosylserine hydrolase activity definition “Catalysis of the reaction: (ADP-D-ribosyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + ADP-ribose.”
- has cross-reference “PMID:28650317”
- has cross-reference “RHEA:58256”
- has cross-reference “PMID:29234005”
ADP-ribosylserine hydrolase activity label “ADP-ribosylserine hydrolase activity”

ADP-ribosylserine hydrolase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31850”^^anyURI
ADP-ribosylserine hydrolase activity has exact synonym “ADP-ribosylserine hydrolase activity”
ADP-ribosylserine hydrolase activity definition “Catalysis of the reaction: O-(ADP-D-ribosyl)-L-seryl-[protein] + H2O = ADP-D-ribose + L-seryl-[protein].”
- has cross-reference “PMID:28650317”
- has cross-reference “RHEA:58256”
- has cross-reference “PMID:29234005”
ADP-ribosylserine hydrolase activity label “ADP-ribosylserine-[protein] hydrolase activity”

ADP-riboxanase activity label “ADP-riboxanase activity”

ADP-riboxanase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31850”^^anyURI
ADP-riboxanase activity has exact synonym “ADP-riboxanase activity”
ADP-riboxanase activity label “ADP-riboxanase-[protein] activity”

[Anopheles ](http://purl.obolibrary.org/obo/NCBITaxon_7164) [TAXRANK_1000000](http://purl.obolibrary.org/obo/TAXRANK_1000000) [TAXRANK_0000005](http://purl.obolibrary.org/obo/TAXRANK_0000005)

Aspergillus label “Aspergillus”

Aspergillus subgen. Fumigati label “Aspergillus subgen. Fumigati”

Aspergillus subgen. Nidulantes label “Aspergillus subgen. Nidulantes”

[Bacillus ](http://purl.obolibrary.org/obo/NCBITaxon_1386) [TAXRANK_1000000](http://purl.obolibrary.org/obo/TAXRANK_1000000) [TAXRANK_0000005](http://purl.obolibrary.org/obo/TAXRANK_0000005)

Bfa1-Bub2 complex definition “A protein complex that acts as a two-component GTPase-activating protein for Tem1 GTPase, thus regulating a signal transduction cascade, called the mitotic exit network (MEN), which is required for mitotic exit and cytokinesis. Bub2/Bfa1 keeps Tem1 inactive until the spindle is properly oriented, thus inhibiting MEN activation.”
- has cross-reference “GOC:bhm”
- has cross-reference “PMID:16449187”
Bfa1-Bub2 complex label “Bfa1-Bub2 complex”

Bfa1-Bub2 complex term tracker item “https://github.com/geneontology/go-ontology/issues/31636”^^anyURI
Bfa1-Bub2 complex has narrow synonym “Bfa1-Bub2 complex”
Bfa1-Bub2 complex has narrow synonym “Byr4-Cdc16 GAP complex”
Bfa1-Bub2 complex definition “A protein complex that acts as a two-component GTPase-activating protein for the Tem1/Spg1 GTPase, thus regulating a signal transduction cascade (the mitotic exit network, MEN, in budding yeast; the septation initiation network, SIN, in fission yeast), which is required for mitotic exit and cytokinesis. The complex keeps the GTPase inactive until the spindle is properly oriented, thus inhibiting MEN/SIN activation.”
- has cross-reference “GOC:bhm”
- has cross-reference “PMID:16449187”
Bfa1-Bub2 complex label “SIN/MEN two-component GAP complex”

C-acyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31814”^^anyURI
C-acyltransferase activity term replaced by acyltransferase activity, transferring groups other than amino-acyl groups
C-acyltransferase activity definition “OBSOLETE. Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule.”
- has cross-reference “GOC:ai”
C-acyltransferase activity deprecated true
C-acyltransferase activity comment “This term was obsoleted because it represents an unnecessary grouping class that lacks an EC cross-reference and leads to misclassification of children.”
C-acyltransferase activity label “obsolete C-acyltransferase activity”

[Coxiella ](http://purl.obolibrary.org/obo/NCBITaxon_776) [TAXRANK_1000000](http://purl.obolibrary.org/obo/TAXRANK_1000000) [TAXRANK_0000005](http://purl.obolibrary.org/obo/TAXRANK_0000005)

[Craniata ](http://purl.obolibrary.org/obo/NCBITaxon_89593) [TAXRANK_1000000](http://purl.obolibrary.org/obo/TAXRANK_1000000) [TAXRANK_0000008](http://purl.obolibrary.org/obo/TAXRANK_0000008)

[Cryptococcus ](http://purl.obolibrary.org/obo/NCBITaxon_5206) [TAXRANK_1000000](http://purl.obolibrary.org/obo/TAXRANK_1000000) [TAXRANK_0000005](http://purl.obolibrary.org/obo/TAXRANK_0000005)

Cypridina-luciferin 2-monooxygenase activity definition “Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light.”
- has cross-reference “MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN”
- has cross-reference “EC:1.13.12.6”

Cypridina-luciferin 2-monooxygenase activity definition “Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light.”
- has cross-reference “EC:1.13.12.6”

DIBOA-glucoside oxygenase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31969”^^anyURI
DIBOA-glucoside oxygenase activity definition “Catalysis of the reaction: DIBOA beta-D-glucoside + 2-oxoglutarate + O2 = TRIBOA beta-D-glucoside + succinate + CO2.”
- has cross-reference “RHEA:32115”
DIBOA-glucoside oxygenase activity SubClassOf 2-oxoglutarate-dependent dioxygenase activity

ER retention sequence binding definition “Binding to an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER.”
- has cross-reference “GOC:ai”
ER retention sequence binding label “ER retention sequence binding”

ER retention sequence binding has narrow synonym “ER retention sequence binding”
ER retention sequence binding definition “Binding to an endoplasmic reticulum (ER) retention sequence, a short stretch of amino acids found in a protein that acts as a signal to retain the protein within the ER.”
- has cross-reference “GOC:ai”
ER retention sequence binding label “ER lumen protein retrieval receptor activity”

[Echinacea ](http://purl.obolibrary.org/obo/NCBITaxon_7674) [TAXRANK_1000000](http://purl.obolibrary.org/obo/TAXRANK_1000000) [TAXRANK_0000020](http://purl.obolibrary.org/obo/TAXRANK_0000020)

Entner-Doudoroff pathway through 6-phosphogluconate term tracker item “https://github.com/geneontology/go-ontology/issues/31916”^^anyURI
Entner-Doudoroff pathway through 6-phosphogluconate term replaced by Entner-Doudoroff pathway
Entner-Doudoroff pathway through 6-phosphogluconate definition “OBSOLETE. A pathway that converts a carbohydrate to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it.”
- has cross-reference “PMID:12981024”
- has cross-reference “PMID:12921356”
- has cross-reference “MetaCyc:PWY-8004”
- has cross-reference “GOC:jl”
Entner-Doudoroff pathway through 6-phosphogluconate deprecated true
Entner-Doudoroff pathway through 6-phosphogluconate comment “This term was obsoleted because the variant Entner-Doudoroff pathways are better represented by the parent term GO:0061678 (Entner-Doudoroff pathway). MetaCyc treats these as ‘variant pathways’ and such variants are better captured as GO-CAMs rather than as nested ontology terms.”
Entner-Doudoroff pathway through 6-phosphogluconate label “obsolete Entner-Doudoroff pathway through 6-phosphogluconate”

Entner-Doudoroff pathway through gluconate term tracker item “https://github.com/geneontology/go-ontology/issues/31916”^^anyURI
Entner-Doudoroff pathway through gluconate term replaced by Entner-Doudoroff pathway
Entner-Doudoroff pathway through gluconate definition “OBSOLETE. The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate.”
- has cross-reference “GOC:dph”
- has cross-reference “PMID:12921536”
Entner-Doudoroff pathway through gluconate deprecated true
Entner-Doudoroff pathway through gluconate comment “This term was obsoleted because the variant Entner-Doudoroff pathways are better represented by the parent term GO:0061678 (Entner-Doudoroff pathway). MetaCyc treats these as ‘variant pathways’ and such variants are better captured as GO-CAMs rather than as nested ontology terms.”
Entner-Doudoroff pathway through gluconate label “obsolete Entner-Doudoroff pathway through gluconate”

Entner-Doudoroff pathway through gluconate to D-glyceraldehyde term tracker item “https://github.com/geneontology/go-ontology/issues/31916”^^anyURI
Entner-Doudoroff pathway through gluconate to D-glyceraldehyde term replaced by Entner-Doudoroff pathway
Entner-Doudoroff pathway through gluconate to D-glyceraldehyde definition “OBSOLETE. The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde.”
- has cross-reference “MetaCyc:NPGLUCAT-PWY”
- has cross-reference “GOC:dph”
- has cross-reference “PMID:12921536”
Entner-Doudoroff pathway through gluconate to D-glyceraldehyde deprecated true
Entner-Doudoroff pathway through gluconate to D-glyceraldehyde comment “This term was obsoleted because the variant Entner-Doudoroff pathways are better represented by the parent term GO:0061678 (Entner-Doudoroff pathway). MetaCyc treats these as ‘variant pathways’ and such variants are better captured as GO-CAMs rather than as nested ontology terms.”
Entner-Doudoroff pathway through gluconate to D-glyceraldehyde label “obsolete Entner-Doudoroff pathway through gluconate to D-glyceraldehyde”

Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate term tracker item “https://github.com/geneontology/go-ontology/issues/31916”^^anyURI
Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate term replaced by Entner-Doudoroff pathway
Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate definition “OBSOLETE. The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde-3-phosphate.”
- has cross-reference “GOC:dph”
- has cross-reference “PMID:12921536”
Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate deprecated true
Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate comment “This term was obsoleted because the variant Entner-Doudoroff pathways are better represented by the parent term GO:0061678 (Entner-Doudoroff pathway). MetaCyc treats these as ‘variant pathways’ and such variants are better captured as GO-CAMs rather than as nested ontology terms.”
Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate label “obsolete Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate”

GABA metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI
GABA metabolic process consider GABA biosynthetic process
GABA metabolic process consider GABA catabolic process
GABA metabolic process definition “OBSOLETE. The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.”
- has cross-reference “ISBN:0198506732”
GABA metabolic process deprecated true
GABA metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
GABA metabolic process label “obsolete GABA metabolic process”

[Gnathostomata ](http://purl.obolibrary.org/obo/NCBITaxon_7776) [TAXRANK_1000000](http://purl.obolibrary.org/obo/TAXRANK_1000000) [TAXRANK_0001004](http://purl.obolibrary.org/obo/TAXRANK_0001004)

L-dopa biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31703”^^anyURI
L-dopa biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of L-dopa.”
- has cross-reference “GO_REF:0000068”
- has cross-reference “PMID:8822146”
- has cross-reference “GOC:PARL”
- has cross-reference “GOC:bf”
- has cross-reference “GOC:TermGenie”
L-dopa biosynthetic process deprecated true
L-dopa biosynthetic process comment “This term was obsoleted because there is no evidence that this process exists.”
L-dopa biosynthetic process label “obsolete L-dopa biosynthetic process”

L-dopa metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31703”^^anyURI
L-dopa metabolic process term replaced by L-dopa catabolic process
L-dopa metabolic process definition “OBSOLETE. The chemical reactions and pathways involving L-dopa.”
- has cross-reference “GO_REF:0000068”
- has cross-reference “PMID:8822146”
- has cross-reference “GOC:PARL”
- has cross-reference “GOC:bf”
- has cross-reference “GOC:TermGenie”
L-dopa metabolic process deprecated true
L-dopa metabolic process comment “This term was obsoleted because there is no evidence that this process exists; L-dopa metabolism has been used in the literature to mean L-dopa degradation.”
L-dopa metabolic process label “obsolete L-dopa metabolic process”

L-glutamine family amino acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.”
- has cross-reference “GOC:ai”
L-glutamine family amino acid biosynthetic process label “L-glutamine family amino acid biosynthetic process”

L-glutamine family amino acid biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/32000”^^anyURI
L-glutamine family amino acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of L-glutamate or any of the amino acids synthesised from it (L-glutamine, L-proline and L-arginine).”
- has cross-reference “GOC:curators”
L-glutamine family amino acid biosynthetic process label “glutamate family amino acid biosynthetic process”

L-isoleucine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31839”^^anyURI
L-isoleucine catabolic process has narrow synonym “L-isoleucine catabolic process via Ehrlich pathway”
L-isoleucine catabolic process has narrow synonym “L-isoleucine degradation via Ehrlich pathway”

L-kynurenine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31588”^^anyURI
L-kynurenine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine).”
- has cross-reference “GOC:yaf”
L-kynurenine catabolic process deprecated true
L-kynurenine catabolic process comment “This term was obsoleted because there is no evidence that this compound is specifically degraded.”
L-kynurenine catabolic process label “obsolete L-kynurenine catabolic process”

L-leucine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31839”^^anyURI
L-leucine catabolic process has narrow synonym “L-leucine degradation via Ehrlich pathway”
L-leucine catabolic process has narrow synonym “L-methionine catabolic process via Ehrlich pathway”

L-methionine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31839”^^anyURI
L-methionine catabolic process has narrow synonym “L-methionine catabolic process via Ehrlich pathway”
L-methionine catabolic process has narrow synonym “L-methionine degradation via Ehrlich pathway”

L-phenylalanine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31839”^^anyURI
L-phenylalanine catabolic process has narrow synonym “L-phenylalanine catabolic process via Ehrlich pathway”
L-phenylalanine catabolic process has narrow synonym “L-phenylalanine degradation via Ehrlich pathway”

L-phenylalanine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI
L-phenylalanine metabolic process consider L-phenylalanine catabolic process
L-phenylalanine metabolic process consider L-phenylalanine biosynthetic process
L-phenylalanine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid.”
- has cross-reference “GOC:mah”
- has cross-reference “GOC:jsg”
L-phenylalanine metabolic process deprecated true
L-phenylalanine metabolic process comment “This term was obsoleted because it us an unnecessary grouping term.”
L-phenylalanine metabolic process label “obsolete L-phenylalanine metabolic process”

L-tryptophan catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31839”^^anyURI
L-tryptophan catabolic process has narrow synonym “L-tryptophan catabolic process via Ehrlich pathway”
L-tryptophan catabolic process has narrow synonym “L-tryptophan degradation via Ehrlich pathway”

L-tryptophan metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI
L-tryptophan metabolic process consider L-tryptophan biosynthetic process
L-tryptophan metabolic process consider L-tryptophan catabolic process
L-tryptophan metabolic process definition “OBSOLETE. The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.”
- has cross-reference “ISBN:0198547684”
L-tryptophan metabolic process deprecated true
L-tryptophan metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
L-tryptophan metabolic process label “obsolete L-tryptophan metabolic process”

L-valine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31839”^^anyURI
L-valine catabolic process has narrow synonym “valine degradation via Ehrlich pathway”

[Leishmania ](http://purl.obolibrary.org/obo/NCBITaxon_5658) [TAXRANK_1000000](http://purl.obolibrary.org/obo/TAXRANK_1000000) [TAXRANK_0000005](http://purl.obolibrary.org/obo/TAXRANK_0000005)

[Leishmania ](http://purl.obolibrary.org/obo/NCBITaxon_38568) [TAXRANK_1000000](http://purl.obolibrary.org/obo/TAXRANK_1000000) [TAXRANK_0000009](http://purl.obolibrary.org/obo/TAXRANK_0000009)

[Mus ](http://purl.obolibrary.org/obo/NCBITaxon_10088) [TAXRANK_1000000](http://purl.obolibrary.org/obo/TAXRANK_1000000) [TAXRANK_0000005](http://purl.obolibrary.org/obo/TAXRANK_0000005)

[Mus ](http://purl.obolibrary.org/obo/NCBITaxon_862507) [TAXRANK_1000000](http://purl.obolibrary.org/obo/TAXRANK_1000000) [TAXRANK_0000009](http://purl.obolibrary.org/obo/TAXRANK_0000009)

N-acyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31814”^^anyURI
N-acyltransferase activity term replaced by acyltransferase activity, transferring groups other than amino-acyl groups
N-acyltransferase activity definition “OBSOLETE. Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule.”
- has cross-reference “GOC:ai”
N-acyltransferase activity deprecated true
N-acyltransferase activity comment “This term was obsoleted because it represents an unnecessary grouping class that lacks an EC cross-reference and leads to misclassification of children.”
N-acyltransferase activity label “obsolete N-acyltransferase activity”

O-acyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31814”^^anyURI
O-acyltransferase activity term replaced by acyltransferase activity, transferring groups other than amino-acyl groups
O-acyltransferase activity definition “OBSOLETE. Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule.”
- has cross-reference “GOC:ai”
O-acyltransferase activity deprecated true
O-acyltransferase activity comment “This term was obsoleted because it represents an unnecessary grouping class that lacks an EC cross-reference and leads to misclassification of children.”
O-acyltransferase activity label “obsolete O-acyltransferase activity”

Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity definition “Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin.”
- has cross-reference “MetaCyc:1.13.12.7-RXN”
- has cross-reference “EC:1.13.12.7”

Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity definition “Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin.”
- has cross-reference “EC:1.13.12.7”

Plasmodium label “Plasmodium”

[Polyphaga ](http://purl.obolibrary.org/obo/NCBITaxon_41084) [TAXRANK_1000000](http://purl.obolibrary.org/obo/TAXRANK_1000000) [TAXRANK_0000014](http://purl.obolibrary.org/obo/TAXRANK_0000014)

[Pterygota ](http://purl.obolibrary.org/obo/NCBITaxon_7496) [TAXRANK_1000000](http://purl.obolibrary.org/obo/TAXRANK_1000000) [TAXRANK_0000007](http://purl.obolibrary.org/obo/TAXRANK_0000007)

RNA translocase activity comment “Note that some gene products that possess DNA translocase activity, such as members of the FtsK/SpoIIIE family, can be fixed in place by interactions with other components of the cell; the relative movement between the protein and DNA bound to it results in movement of the DNA within the cell, often across a membrane.”

RNA translocase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31772”^^anyURI

Renilla-luciferin 2-monooxygenase activity definition “Catalysis of the reaction: Renilla luciferin + O2 = oxidized Renilla luciferin + CO2 + light.”
- has cross-reference “MetaCyc:RENILLA-LUCIFERIN-2-MONOOXYGENASE-RXN”
- has cross-reference “EC:1.13.12.5”

Renilla-luciferin 2-monooxygenase activity definition “Catalysis of the reaction: Renilla luciferin + O2 = oxidized Renilla luciferin + CO2 + light.”
- has cross-reference “EC:1.13.12.5”

[Ricinus ](http://purl.obolibrary.org/obo/NCBITaxon_3987) [TAXRANK_1000000](http://purl.obolibrary.org/obo/TAXRANK_1000000) [TAXRANK_0000005](http://purl.obolibrary.org/obo/TAXRANK_0000005)

S-acyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31814”^^anyURI
S-acyltransferase activity term replaced by acyltransferase activity, transferring groups other than amino-acyl groups
S-acyltransferase activity definition “OBSOLETE. Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule.”
- has cross-reference “GOC:ai”
S-acyltransferase activity deprecated true
S-acyltransferase activity comment “This term was obsoleted because it represents an unnecessary grouping class that lacks an EC cross-reference and leads to misclassification of children.”
S-acyltransferase activity label “obsolete S-acyltransferase activity”

[Setaria ](http://purl.obolibrary.org/obo/NCBITaxon_4554) [TAXRANK_1000000](http://purl.obolibrary.org/obo/TAXRANK_1000000) [TAXRANK_0000005](http://purl.obolibrary.org/obo/TAXRANK_0000005)

AnnotationProperty: TAXRANK_1000000

[Theria ](http://purl.obolibrary.org/obo/NCBITaxon_32525) [TAXRANK_1000000](http://purl.obolibrary.org/obo/TAXRANK_1000000) [TAXRANK_0001004](http://purl.obolibrary.org/obo/TAXRANK_0001004)

[Tribolium ](http://purl.obolibrary.org/obo/NCBITaxon_7069) [TAXRANK_1000000](http://purl.obolibrary.org/obo/TAXRANK_1000000) [TAXRANK_0000005](http://purl.obolibrary.org/obo/TAXRANK_0000005)

[Vertebrata ](http://purl.obolibrary.org/obo/NCBITaxon_7742) [TAXRANK_1000000](http://purl.obolibrary.org/obo/TAXRANK_1000000) [TAXRANK_0001004](http://purl.obolibrary.org/obo/TAXRANK_0001004)

Watasenia-luciferin 2-monooxygenase activity definition “Catalysis of the reaction: Watasenia luciferin + O2 = oxidized Watasenia luciferin + CO2 + light.”
- has cross-reference “EC:1.13.12.8”
- has cross-reference “MetaCyc:WATASEMIA-LUCIFERIN-2-MONOOXYGENASE-RXN”

Watasenia-luciferin 2-monooxygenase activity definition “Catalysis of the reaction: Watasenia luciferin + O2 = oxidized Watasenia luciferin + CO2 + light.”
- has cross-reference “EC:1.13.12.8”

[Xenopus ](http://purl.obolibrary.org/obo/NCBITaxon_8353) [TAXRANK_1000000](http://purl.obolibrary.org/obo/TAXRANK_1000000) [TAXRANK_0000005](http://purl.obolibrary.org/obo/TAXRANK_0000005)

[Yersinia ](http://purl.obolibrary.org/obo/NCBITaxon_629) [TAXRANK_1000000](http://purl.obolibrary.org/obo/TAXRANK_1000000) [TAXRANK_0000005](http://purl.obolibrary.org/obo/TAXRANK_0000005)

Yersinia pestis TAXRANK_1000000 TAXRANK_0000006
Yersinia pestis has_related_synonym “Yersinia pestis (Lehmann and Neumann 1896) van Loghem 1944 (Approved Lists 1980), nom. cons.”
- has_synonym_type synonym

acetate CoA-transferase activity definition “Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.”
- has cross-reference “EC:2.8.3.8”

acetate CoA-transferase activity definition “Catalysis of the reaction: an acyl-CoA + acetate = a carboxylate + acetyl-CoA.”
- has cross-reference “RHEA:13381”

acetoacetic acid biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31806”^^anyURI
acetoacetic acid biosynthetic process term replaced by ketone body biosynthetic process
acetoacetic acid biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH.”
- has cross-reference “GOC:jl”
acetoacetic acid biosynthetic process deprecated true
acetoacetic acid biosynthetic process comment “This term was obsoleted because it represents a specific substrate of ketone body biosynthetic process ; GO:0046951.”
acetoacetic acid biosynthetic process label “obsolete acetoacetic acid biosynthetic process”

acetoacetic acid catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31806”^^anyURI
acetoacetic acid catabolic process term replaced by ketone body catabolic process
acetoacetic acid catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH.”
- has cross-reference “GOC:jl”
acetoacetic acid catabolic process deprecated true
acetoacetic acid catabolic process comment “This term was obsoleted because it represents a specific substrate of ketone body catabolic process ; GO:0046952.”
acetoacetic acid catabolic process label “obsolete acetoacetic acid catabolic process”

acetoacetic acid metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31806”^^anyURI
acetoacetic acid metabolic process definition “OBSOLETE. The chemical reactions and pathways involving acetoacetic acid, 3-oxobutanoic acid; the empirical formula is C4H6O3 or CH3COCH2COOH.”
- has cross-reference “Wikipedia:Acetoacetic_acid”
acetoacetic acid metabolic process deprecated true
acetoacetic acid metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
acetoacetic acid metabolic process label “obsolete acetoacetic acid metabolic process”

acrolein reductase activity definition “Catalysis of the reaction: acrolein + NADPH + H+ = propanal + NADP.”
- has cross-reference “PMID:21169366”
- has cross-reference “GOC:pz”

actin capping protein of dynactin complex term tracker item “https://github.com/geneontology/go-ontology/issues/31956”^^anyURI
actin capping protein of dynactin complex term replaced by F-actin capping protein complex
actin capping protein of dynactin complex definition “OBSOLETE. A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, nucleates the polymerization of actin monomers but does not sever actin filaments, and which is a part of the dynactin complex.”
- has cross-reference “PMID:18221362”
- has cross-reference “GOC:jl”
- has cross-reference “PMID:18544499”
actin capping protein of dynactin complex deprecated true
actin capping protein of dynactin complex comment “This term was obsoleted because it is redundant with GO:0008290 (F-actin capping protein complex). Annotations can be migrated to the replacement term.”
actin capping protein of dynactin complex label “obsolete actin capping protein of dynactin complex”

activation of bipolar cell growth term tracker item “https://github.com/geneontology/go-ontology/issues/31746”^^anyURI
activation of bipolar cell growth term replaced by positive regulation of bipolar cell growth
activation of bipolar cell growth definition “OBSOLETE. Any process that initiates the inactive process of bipolar cell growth, polarized growth from both ends of a cell.”
- has cross-reference “GOC:ai”
activation of bipolar cell growth deprecated true
activation of bipolar cell growth comment “This term was obsoleted because it represented the same process as its parent, positive regulation of bipolar cell growth ; GO:0051518.”
activation of bipolar cell growth label “obsolete activation of bipolar cell growth”

alkyl hydroperoxide reductase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31961”^^anyURI
alkyl hydroperoxide reductase activity term replaced by NADH-dependent peroxiredoxin activity
alkyl hydroperoxide reductase activity definition “OBSOLETE. Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol.”
- has cross-reference “GOC:curators”
alkyl hydroperoxide reductase activity deprecated true
alkyl hydroperoxide reductase activity comment “The reason for obsoletion is that, despite the generic-sounding name, this term represented a substrate-specific activity that is more specific than the specificity of any known gene product. ‘Alkyl hydroperoxide reductase’ is listed as a synonym of EC 1.11.1.26, which corresponds to GO:0102039 NADH-dependent peroxiredoxin activity, the appropriate replacement.”
alkyl hydroperoxide reductase activity label “obsolete alkyl hydroperoxide reductase activity”

alpha-amino acid biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31993”^^anyURI
alpha-amino acid biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of an alpha-amino acid.”
- has cross-reference “GOC:TermGenie”
alpha-amino acid biosynthetic process deprecated true
alpha-amino acid biosynthetic process comment “The reason for obsoletion is that this term was an unnecessary grouping term and more specific terms were created.”
alpha-amino acid biosynthetic process label “obsolete alpha-amino acid biosynthetic process”

alpha-amino acid catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31993”^^anyURI
alpha-amino acid catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid.”
- has cross-reference “GOC:TermGenie”
alpha-amino acid catabolic process deprecated true
alpha-amino acid catabolic process comment “The reason for obsoletion is that this term was an unnecessary grouping term.”
alpha-amino acid catabolic process label “obsolete alpha-amino acid catabolic process”

alpha-amino acid metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31993”^^anyURI
alpha-amino acid metabolic process definition “OBSOLETE. The chemical reactions and pathways involving an alpha-amino acid.”
- has cross-reference “GOC:TermGenie”
alpha-amino acid metabolic process deprecated true
alpha-amino acid metabolic process comment “The reason for obsoletion is that this term was an unnecessary grouping term and more specific terms were created.”
alpha-amino acid metabolic process label “obsolete alpha-amino acid metabolic process”

amino acid catabolic process to alcohol via Ehrlich pathway definition “The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.”
- has cross-reference “PMID:18281432”
- has cross-reference “GOC:krc”
amino acid catabolic process to alcohol via Ehrlich pathway label “amino acid catabolic process to alcohol via Ehrlich pathway”
amino acid catabolic process to alcohol via Ehrlich pathway SubClassOf amino acid catabolic process via Ehrlich pathway
amino acid catabolic process to alcohol via Ehrlich pathway SubClassOf alcohol biosynthetic process

amino acid catabolic process to alcohol via Ehrlich pathway term tracker item “https://github.com/geneontology/go-ontology/issues/31839”^^anyURI
amino acid catabolic process to alcohol via Ehrlich pathway definition “OBSOLETE. The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.”
- has cross-reference “PMID:18281432”
- has cross-reference “GOC:krc”
amino acid catabolic process to alcohol via Ehrlich pathway deprecated true
amino acid catabolic process to alcohol via Ehrlich pathway comment “This term was obsoleted because it represents multiple specific pathways. Consider specific amino acid catabolic processes.”
amino acid catabolic process to alcohol via Ehrlich pathway label “obsolete amino acid catabolic process to alcohol via Ehrlich pathway”

amino acid catabolic process to carboxylic acid via Ehrlich pathway definition “The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.”
- has cross-reference “PMID:18281432”
- has cross-reference “GOC:krc”
amino acid catabolic process to carboxylic acid via Ehrlich pathway label “amino acid catabolic process to carboxylic acid via Ehrlich pathway”
amino acid catabolic process to carboxylic acid via Ehrlich pathway SubClassOf amino acid catabolic process via Ehrlich pathway
amino acid catabolic process to carboxylic acid via Ehrlich pathway SubClassOf carboxylic acid biosynthetic process

amino acid catabolic process to carboxylic acid via Ehrlich pathway term tracker item “https://github.com/geneontology/go-ontology/issues/31839”^^anyURI
amino acid catabolic process to carboxylic acid via Ehrlich pathway definition “OBSOLETE. The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.”
- has cross-reference “PMID:18281432”
- has cross-reference “GOC:krc”
amino acid catabolic process to carboxylic acid via Ehrlich pathway deprecated true
amino acid catabolic process to carboxylic acid via Ehrlich pathway comment “This term was obsoleted because it represents multiple specific pathways. Consider specific amino acid catabolic processes.”
amino acid catabolic process to carboxylic acid via Ehrlich pathway label “obsolete amino acid catabolic process to carboxylic acid via Ehrlich pathway”

amino acid catabolic process via Ehrlich pathway definition “The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols or carboxylic acids containing one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives, sometimes referred to as fusel acids, may be produced instead of alcohols.”
- has cross-reference “PMID:18281432”
- has cross-reference “GOC:krc”
amino acid catabolic process via Ehrlich pathway label “amino acid catabolic process via Ehrlich pathway”
amino acid catabolic process via Ehrlich pathway SubClassOf amino acid catabolic process

amino acid catabolic process via Ehrlich pathway term tracker item “https://github.com/geneontology/go-ontology/issues/31839”^^anyURI
amino acid catabolic process via Ehrlich pathway definition “OBSOLETE. The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols or carboxylic acids containing one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives, sometimes referred to as fusel acids, may be produced instead of alcohols.”
- has cross-reference “PMID:18281432”
- has cross-reference “GOC:krc”
amino acid catabolic process via Ehrlich pathway deprecated true
amino acid catabolic process via Ehrlich pathway comment “This term was obsoleted because it represents multiple specific pathways. Consider specific amino acid catabolic processes.”
amino acid catabolic process via Ehrlich pathway label “obsolete amino acid catabolic process via Ehrlich pathway”

anaerobic carbon-monoxide dehydrogenase activity definition “Catalysis of the reaction: CO + H2O + oxidized ferredoxin = CO2 + reduced ferredoxin.”
- has cross-reference “RHEA:21040”

anaerobic carbon-monoxide dehydrogenase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31984”^^anyURI
anaerobic carbon-monoxide dehydrogenase activity definition “Catalysis of the reaction: CO + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O = 2 reduced [2Fe-2S]-[ferredoxin] + CO2 + 2 H+.”
- has cross-reference “RHEA:21040”

anatomical entity definition “Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species.”

aromatic amino acid family biosynthetic process definition “The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).”
- has cross-reference “GOC:curators”
aromatic amino acid family biosynthetic process label “aromatic amino acid family biosynthetic process”

aromatic amino acid family biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/32000”^^anyURI
aromatic amino acid family biosynthetic process definition “The chemical reactions and pathways resulting in the formation of an amino acid whose structure includes an aromatic ring.”
- has cross-reference “GOC:curators”
aromatic amino acid family biosynthetic process label “aromatic amino acid biosynthetic process”

aromatic amino acid family biosynthetic process, prephenate pathway term tracker item “https://github.com/geneontology/go-ontology/issues/32005”^^anyURI
aromatic amino acid family biosynthetic process, prephenate pathway consider L-tyrosine biosynthetic process
aromatic amino acid family biosynthetic process, prephenate pathway consider L-phenylalanine biosynthetic process
aromatic amino acid family biosynthetic process, prephenate pathway definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of phenylalanine and tyrosine from other compounds, including chorismate, via the intermediate prephenate.”
- has cross-reference “GOC:mah”
- has cross-reference “ISBN:0471331309”
- has cross-reference “MetaCyc:PWY-3481”
aromatic amino acid family biosynthetic process, prephenate pathway deprecated true
aromatic amino acid family biosynthetic process, prephenate pathway comment “This term was obsoleted because it represents a pre-composed pathway combining L-phenylalanine and L-tyrosine biosynthesis. MetaCyc:PWY-3481 is the ‘superpathway of L-phenylalanine and L-tyrosine biosynthesis’ and is composed of two separate pathways (PWY-3462 L-phenylalanine biosynthesis II and PWY-3461 L-tyrosine biosynthesis II) which are already represented as narrowMatch xrefs on GO:0009094 (L-phenylalanine biosynthetic process) and GO:0006571 (L-tyrosine biosynthetic process), respectively. Annotations should be transferred to the appropriate consider term(s).”
aromatic amino acid family biosynthetic process, prephenate pathway label “obsolete aromatic amino acid biosynthetic process, prephenate pathway”

aromatic amino acid family catabolic process definition “The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).”
- has cross-reference “GOC:curators”
aromatic amino acid family catabolic process label “aromatic amino acid family catabolic process”

aromatic amino acid family catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/32000”^^anyURI
aromatic amino acid family catabolic process definition “The chemical reactions and pathways resulting in the breakdown of an amino acid whose structure includes an aromatic ring.”
- has cross-reference “GOC:curators”
aromatic amino acid family catabolic process label “aromatic amino acid catabolic process”

aromatic amino acid family catabolic process to alcohol via Ehrlich pathway definition “The chemical reactions and pathways involving the catabolism of aromatic amino acids to produce aromatic alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanol, 4-hydroxyphenylethanol, or tryptophol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.”
- has cross-reference “PMID:18281432”
- has cross-reference “GOC:krc”
aromatic amino acid family catabolic process to alcohol via Ehrlich pathway label “aromatic amino acid family catabolic process to alcohol via Ehrlich pathway”
aromatic amino acid family catabolic process to alcohol via Ehrlich pathway SubClassOf amino acid catabolic process to alcohol via Ehrlich pathway
aromatic amino acid family catabolic process to alcohol via Ehrlich pathway SubClassOf aromatic amino acid family catabolic process

aromatic amino acid family catabolic process to alcohol via Ehrlich pathway term tracker item “https://github.com/geneontology/go-ontology/issues/31839”^^anyURI
aromatic amino acid family catabolic process to alcohol via Ehrlich pathway consider L-phenylalanine catabolic process
aromatic amino acid family catabolic process to alcohol via Ehrlich pathway consider L-tryptophan catabolic process
aromatic amino acid family catabolic process to alcohol via Ehrlich pathway consider L-tyrosine catabolic process
aromatic amino acid family catabolic process to alcohol via Ehrlich pathway definition “OBSOLETE. The chemical reactions and pathways involving the catabolism of aromatic amino acids to produce aromatic alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanol, 4-hydroxyphenylethanol, or tryptophol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.”
- has cross-reference “PMID:18281432”
- has cross-reference “GOC:krc”
aromatic amino acid family catabolic process to alcohol via Ehrlich pathway deprecated true
aromatic amino acid family catabolic process to alcohol via Ehrlich pathway comment “This term was obsoleted because it represents multiple specific pathways. Consider specific amino acid catabolic processes.”
aromatic amino acid family catabolic process to alcohol via Ehrlich pathway label “obsolete aromatic amino acid family catabolic process to alcohol via Ehrlich pathway”

aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway definition “The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanoate, 4-hydroxyphenylethanoate, or 2-(Indol-3-yl)-ethanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.”
- has cross-reference “PMID:18281432”
- has cross-reference “GOC:krc”
aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway label “aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway”
aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway SubClassOf amino acid catabolic process to carboxylic acid via Ehrlich pathway
aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway SubClassOf aromatic amino acid family catabolic process

aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway term tracker item “https://github.com/geneontology/go-ontology/issues/31839”^^anyURI
aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway consider L-phenylalanine catabolic process
aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway consider L-tryptophan catabolic process
aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway consider L-tyrosine catabolic process
aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway definition “OBSOLETE. The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanoate, 4-hydroxyphenylethanoate, or 2-(Indol-3-yl)-ethanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.”
- has cross-reference “PMID:18281432”
- has cross-reference “GOC:krc”
aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway deprecated true
aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway comment “This term was obsoleted because it represents multiple specific pathways. Consider specific amino acid catabolic processes.”
aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway label “obsolete aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway”

aspartate family amino acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine.”
- has cross-reference “GOC:ai”

aspartate family amino acid biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/32000”^^anyURI
aspartate family amino acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of L-aspartate or any of the amino acids synthesised from it (L-asparagine, L-lysine, L-methionine, L-threonine and L-isoleucine).”
- has cross-reference “GOC:curators”

atrazine catabolic process to cyanuric acid term tracker item “https://github.com/geneontology/go-ontology/issues/31766”^^anyURI
atrazine catabolic process to cyanuric acid term replaced by atrazine catabolic process
atrazine catabolic process to cyanuric acid definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into cyanuric acid.”
- has cross-reference “GOC:jl”
atrazine catabolic process to cyanuric acid deprecated true
atrazine catabolic process to cyanuric acid comment “The reason for obsoletion is that this term represents a GO-CAM model.”
atrazine catabolic process to cyanuric acid label “obsolete atrazine catabolic process to cyanuric acid”

atrazine catabolic process to isopropylamine term tracker item “https://github.com/geneontology/go-ontology/issues/31766”^^anyURI
atrazine catabolic process to isopropylamine term replaced by atrazine catabolic process
atrazine catabolic process to isopropylamine definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into isopropylamine.”
- has cross-reference “GOC:jl”
atrazine catabolic process to isopropylamine deprecated true
atrazine catabolic process to isopropylamine comment “The reason for obsoletion is that this term represents a GO-CAM model.”
atrazine catabolic process to isopropylamine label “obsolete atrazine catabolic process to isopropylamine”

atrazine catabolic process to urea term tracker item “https://github.com/geneontology/go-ontology/issues/31766”^^anyURI
atrazine catabolic process to urea term replaced by atrazine catabolic process
atrazine catabolic process to urea definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into urea.”
- has cross-reference “GOC:jl”
atrazine catabolic process to urea deprecated true
atrazine catabolic process to urea comment “The reason for obsoletion is that this term represents a GO-CAM model.”
atrazine catabolic process to urea label “obsolete atrazine catabolic process to urea”

autophagosome-membrane adaptor activity definition “The binding activity of a molecule that brings together a target membrane and an autophagosome during autophagy.”
- has cross-reference “PMID:30544615”
- has cross-reference “PMID:36635405”
autophagosome-membrane adaptor activity SubClassOf protein-membrane adaptor activity

autophagosome-membrane adaptor activity term tracker item “https://github.com/geneontology/go-ontology/issues/31866”^^anyURI
autophagosome-membrane adaptor activity definition “The binding activity of a molecule that brings together a target membrane and an autophagosome membrane during autophagy.”
- has cross-reference “PMID:30544615”
- has cross-reference “PMID:36635405”
autophagosome-membrane adaptor activity SubClassOf membrane-membrane adaptor activity

benzene 1,2-dioxygenase activity definition “Catalysis of the reaction: benzene + H+ + NADH + O2 = cis-cyclohexa-3,5-diene-1,2-diol + NAD+.”
- has cross-reference “EC:1.14.12.3”
- has cross-reference “RHEA:13813”

benzene 1,2-dioxygenase activity definition “Catalysis of the reaction: benzene + NADH + O2 + H+ = cis-1,2-dihydrobenzene-1,2-diol + NAD+.”
- has cross-reference “RHEA:13813”

benzoate 1,2-dioxygenase activity definition “Catalysis of the reaction: benzoate + NADH + H+ + O2 = catechol + CO2 + NAD+.”
- has cross-reference “EC:1.14.12.10”

benzoate 1,2-dioxygenase activity definition “Catalysis of the reaction: benzoate + NADH + O2 + H+ = (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD+.”
- has cross-reference “RHEA:12633”

beta-alanine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI
beta-alanine metabolic process consider beta-alanine biosynthetic process
beta-alanine metabolic process consider beta-alanine catabolic process
beta-alanine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins.”
- has cross-reference “ISBN:0198506732”
- has cross-reference “GOC:jl”
beta-alanine metabolic process deprecated true
beta-alanine metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
beta-alanine metabolic process label “obsolete beta-alanine metabolic process”

biological_process definition “A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.”

biphenyl 2,3-dioxygenase activity definition “Catalysis of the reaction: biphenyl + NADH + H+ + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+. This reaction requires Fe2+.”
- has cross-reference “EC:1.14.12.18”

biphenyl 2,3-dioxygenase activity definition “Catalysis of the reaction: biphenyl + NADH + H+ + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+. This reaction requires Fe2+.”
- has cross-reference “RHEA:18165”

branched-chain amino acid catabolic process to alcohol via Ehrlich pathway definition “The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanol, 2-methylbutanol, or 2-methylpropanol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.”
- has cross-reference “PMID:18281432”
- has cross-reference “GOC:krc”
branched-chain amino acid catabolic process to alcohol via Ehrlich pathway label “branched-chain amino acid catabolic process to alcohol via Ehrlich pathway”
branched-chain amino acid catabolic process to alcohol via Ehrlich pathway SubClassOf amino acid catabolic process to alcohol via Ehrlich pathway
branched-chain amino acid catabolic process to alcohol via Ehrlich pathway SubClassOf branched-chain amino acid catabolic process

branched-chain amino acid catabolic process to alcohol via Ehrlich pathway term tracker item “https://github.com/geneontology/go-ontology/issues/31839”^^anyURI
branched-chain amino acid catabolic process to alcohol via Ehrlich pathway consider L-isoleucine catabolic process
branched-chain amino acid catabolic process to alcohol via Ehrlich pathway consider L-leucine catabolic process
branched-chain amino acid catabolic process to alcohol via Ehrlich pathway consider L-valine catabolic process
branched-chain amino acid catabolic process to alcohol via Ehrlich pathway definition “OBSOLETE. The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanol, 2-methylbutanol, or 2-methylpropanol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.”
- has cross-reference “PMID:18281432”
- has cross-reference “GOC:krc”
branched-chain amino acid catabolic process to alcohol via Ehrlich pathway deprecated true
branched-chain amino acid catabolic process to alcohol via Ehrlich pathway comment “This term was obsoleted because it represents multiple specific pathways. Consider specific amino acid catabolic processes.”
branched-chain amino acid catabolic process to alcohol via Ehrlich pathway label “obsolete branched-chain amino acid catabolic process to alcohol via Ehrlich pathway”

branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway definition “The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanoate, 2-methylbutanoate, or 2-methylpropanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.”
- has cross-reference “PMID:18281432”
- has cross-reference “GOC:krc”
branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway label “branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway”
branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway SubClassOf amino acid catabolic process to carboxylic acid via Ehrlich pathway
branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway SubClassOf branched-chain amino acid catabolic process

branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway term tracker item “https://github.com/geneontology/go-ontology/issues/31839”^^anyURI
branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway consider L-isoleucine catabolic process
branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway consider L-leucine catabolic process
branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway consider L-valine catabolic process
branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway definition “OBSOLETE. The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanoate, 2-methylbutanoate, or 2-methylpropanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.”
- has cross-reference “PMID:18281432”
- has cross-reference “GOC:krc”
branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway deprecated true
branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway comment “This term was obsoleted because it represents multiple specific pathways. Consider specific amino acid catabolic processes.”
branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway label “obsolete branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway”

butyrate-acetoacetate CoA-transferase activity definition “Catalysis of the reaction: acetoacetate + butanoyl-CoA = acetoacetyl-CoA + butanoate.”
- has cross-reference “EC:2.8.3.9”
- has cross-reference “RHEA:12961”

butyrate-acetoacetate CoA-transferase activity definition “Catalysis of the reaction: acetoacetate + butanoyl-CoA = acetoacetyl-CoA + butanoate.”
- has cross-reference “RHEA:12961”

catecholamine transport term tracker item “https://github.com/geneontology/go-ontology/issues/31143”^^anyURI
catecholamine transport definition “OBSOLETE. The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.”
- has cross-reference “GOC:ai”
- has cross-reference “ISBN:0198506732”
catecholamine transport deprecated true
catecholamine transport comment “The reason for obsoletion is that this is an unnecessary grouping term and annotations should be made to more mechanism/location specific terms.”
catecholamine transport label “obsolete catecholamine transport”

cell definition “A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.”

cellular_component definition “A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).”

chloroplast targeting sequence binding definition “Binding to a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast.”
- has cross-reference “GOC:mah”
chloroplast targeting sequence binding label “chloroplast targeting sequence binding”

chloroplast targeting sequence binding term tracker item “https://github.com/geneontology/go-ontology/issues/31419”^^anyURI
chloroplast targeting sequence binding has narrow synonym “chloroplast targeting sequence binding”
chloroplast targeting sequence binding definition “Binding to a chloroplast targeting sequence, a short stretch of amino acids found in a protein that acts as a signal to localize the protein to the chloroplast.”
- has cross-reference “PMID:35929083”
chloroplast targeting sequence binding label “chloroplast targeting sequence receptor activity”

ciliary basal body-plasma membrane docking never in taxon Zygnematales
ciliary basal body-plasma membrane docking never in taxon Gnetales
ciliary basal body-plasma membrane docking never in taxon Magnoliopsida
ciliary basal body-plasma membrane docking never in taxon Ascomycota
ciliary basal body-plasma membrane docking never in taxon Dictyostelium
ciliary basal body-plasma membrane docking created by “pr”
ciliary basal body-plasma membrane docking creation date “2016-08-05T16:12:33Z”
ciliary basal body-plasma membrane docking has exact synonym “ciliary basal body docking”
ciliary basal body-plasma membrane docking has_related_synonym “anchoring of the basal body to the plasma membrane”
ciliary basal body-plasma membrane docking definition “The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane.”
- has cross-reference “PMID:26981235”
- has cross-reference “PMID:23348840”
- has cross-reference “PMID:13978319”
- has cross-reference “PMID:25686250”
- has cross-reference “GOC:cilia”
- has cross-reference “PMID:23530209”
ciliary basal body-plasma membrane docking comment “Basal bodies in jawed vertebrates appear to first attach to a ciliary vesicle. It is unclear how specific this is to jawed vertebrates or if other organisms also employ this sequence. Some species like Giardia intestinalis do not relocate their basal bodies to the plasma membrane, but have their axonemes extend through the cytosol to then protrude out of the cell to form flagella.”
ciliary basal body-plasma membrane docking label “ciliary basal body-plasma membrane docking”
ciliary basal body-plasma membrane docking SubClassOf organelle localization by membrane tethering
ciliary basal body-plasma membrane docking SubClassOf not (in taxon some Zygnematales)
ciliary basal body-plasma membrane docking SubClassOf not (in taxon some Gnetales)
ciliary basal body-plasma membrane docking SubClassOf not (in taxon some Magnoliopsida)
ciliary basal body-plasma membrane docking SubClassOf not (in taxon some Ascomycota)
ciliary basal body-plasma membrane docking SubClassOf not (in taxon some Dictyostelium)
ciliary basal body-plasma membrane docking SubClassOf part of some cilium assembly
ciliary basal body-plasma membrane docking SubClassOf in taxon some Eukaryota

ciliary basal body-plasma membrane docking term tracker item “https://github.com/geneontology/go-ontology/issues/31882”^^anyURI
ciliary basal body-plasma membrane docking term replaced by ciliary transition zone assembly
ciliary basal body-plasma membrane docking definition “OBSOLETE. The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane.”
- has cross-reference “PMID:26981235”
- has cross-reference “PMID:23348840”
- has cross-reference “PMID:13978319”
- has cross-reference “PMID:25686250”
- has cross-reference “GOC:cilia”
- has cross-reference “PMID:23530209”
ciliary basal body-plasma membrane docking deprecated true
ciliary basal body-plasma membrane docking comment “The reason for obsoletion is that this term is redundant with GO:1905349 ciliary transition zone assembly. Per PMID:27646273, transition zone assembly is a complex process that begins with docking of the mother centriole to cytoplasmic vesicles, so the docking step is encompassed by transition zone assembly.”
ciliary basal body-plasma membrane docking label “obsolete ciliary basal body-plasma membrane docking”

ciliary transition fiber assembly term tracker item “https://github.com/geneontology/go-ontology/issues/31882”^^anyURI
ciliary transition fiber assembly term replaced by ciliary transition zone assembly
ciliary transition fiber assembly definition “OBSOLETE. The aggregation, arrangement and bonding together of a set of components to form a ciliary transition fiber.”
- has cross-reference “GO_REF:0000079”
- has cross-reference “GOC:cilia”
- has cross-reference “PMID:24189274”
- has cross-reference “GOC:TermGenie”
ciliary transition fiber assembly deprecated true
ciliary transition fiber assembly comment “The reason for obsoletion is that this term is redundant with GO:1905349 ciliary transition zone assembly. Ciliary transition fiber assembly is part of transition zone assembly and the term had no annotations.”
ciliary transition fiber assembly label “obsolete ciliary transition fiber assembly”

cinnamoyl-CoA:phenyllactate CoA-transferase activity definition “Catalysis of the reaction: (R)-3-phenyllactate + [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonatooxy)oxolan-2-yl]methyl {[(3R)-3-hydroxy-2,2-dimethyl-3-({2-[(2-{[(2E)-3-phenylprop-2-enoyl]sulfanyl}ethyl)carbamoyl]ethyl}carbamoyl)propyl phosphonato]oxy}phosphonate = (R)-3-phenyllactoyl-CoA + trans-cinnamate.”
- has cross-reference “EC:2.8.3.17”
- has cross-reference “RHEA:15601”

cinnamoyl-CoA:phenyllactate CoA-transferase activity definition “Catalysis of the reaction: (E)-cinnamoyl-CoA + (R)-3-phenyllactate = (R)-3-phenyllactoyl-CoA + (E)-cinnamate.”
- has cross-reference “RHEA:15601”

citramalate CoA-transferase activity definition “Catalysis of the reaction: acetyl-CoA + citramalate = acetate + (3S)-citramalyl-CoA.”
- has cross-reference “MetaCyc:CITRAMALATE-COA-TRANSFERASE-RXN”
- has cross-reference “EC:2.8.3.11”

citramalate CoA-transferase activity definition “Catalysis of the reaction: citramalate + acetyl-CoA = (3S)-citramalyl-CoA + acetate.”
- has cross-reference “RHEA:17621”

citrate CoA-transferase activity definition “Catalysis of the reaction: acetyl-CoA + citrate = acetate + (3S)-citryl-CoA.”
- has cross-reference “EC:2.8.3.10”

citrate CoA-transferase activity definition “Catalysis of the reaction: acetyl-CoA + citrate = acetate + (3S)-citryl-CoA.”
- has cross-reference “RHEA:19405”

citrulline metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI
citrulline metabolic process consider citrulline biosynthetic process
citrulline metabolic process consider L-citrulline catabolic process
citrulline metabolic process definition “OBSOLETE. The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins.”
- has cross-reference “ISBN:0198506732”
citrulline metabolic process deprecated true
citrulline metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
citrulline metabolic process label “obsolete citrulline metabolic process”

contractile vacuole tethering involved in discharge term tracker item “https://github.com/geneontology/go-ontology/issues/31870”^^anyURI
contractile vacuole tethering involved in discharge term replaced by contractile vacuole-plasma membrane tether activity
contractile vacuole tethering involved in discharge definition “OBSOLETE. The initial, indirect interaction between a contractile vacuole membrane and a site of discharge in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion.”
- has cross-reference “PMID:22323285”
contractile vacuole tethering involved in discharge deprecated true
contractile vacuole tethering involved in discharge comment “Obsoleted because this term describes a molecular function (tethering activity) rather than a biological process. Replaced by the molecular_function term GO:7770067 contractile vacuole-plasma membrane tether activity.”
contractile vacuole tethering involved in discharge label “obsolete contractile vacuole tethering involved in discharge”

cysteine transport has narrow synonym “L-cysteine transport”
cysteine transport definition “The directed movement of cysteine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- has cross-reference “ISBN:0198506732”
- has cross-reference “GOC:jl”
cysteine transport label “cysteine transport”
cysteine transport EquivalentTo transport and (has primary input some cysteine zwitterion)
cysteine transport SubClassOf organic cation transport
cysteine transport SubClassOf has primary input some cysteine zwitterion

cysteine transport has_broad_synonym “cysteine transport”
cysteine transport definition “The directed movement of L-cysteine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- has cross-reference “ISBN:0198506732”
- has cross-reference “GOC:jl”
cysteine transport label “L-cysteine transport”
cysteine transport EquivalentTo transport and (has primary input some L-cysteine zwitterion)
cysteine transport SubClassOf L-amino acid transport
cysteine transport SubClassOf has primary input some L-cysteine zwitterion

cysteinyl-tRNA aminoacylation definition “The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2’-OH group of a cysteine-accetping tRNA. The 2’-O-aminoacyl-tRNA will ultimately migrate to the 3’ position via transesterification.”
- has cross-reference “ISBN:0716730510”
- has cross-reference “GOC:mcc”

cysteinyl-tRNA aminoacylation definition “The process of coupling L-cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2’-OH group of a cysteine-accepting tRNA. The 2’-O-aminoacyl-tRNA will ultimately migrate to the 3’ position via transesterification.”
- has cross-reference “ISBN:0716730510”
- has cross-reference “GOC:mcc”

Class: cytoplasmic lattice complex
cytoplasmic lattice complex term tracker item “https://github.com/geneontology/go-ontology/issues/31998”^^anyURI
cytoplasmic lattice complex created by “pg”
cytoplasmic lattice complex creation date “2026-04-30T10:01:02Z”
cytoplasmic lattice complex has_obo_namespace “cellular_component”
cytoplasmic lattice complex id “GO:0140419”
cytoplasmic lattice complex definition “A protein complex at least composed of PADI6, TLE6, NLRP14 and KHDC3 that forms fibrous structures in the mammalian ooplasm.”
- has cross-reference “PMID:41845018”
- has cross-reference “PMID:41917274”
- has cross-reference “PMID:41986725”
cytoplasmic lattice complex label “cytoplasmic lattice complex”
cytoplasmic lattice complex SubClassOf protein-containing complex

cytoskeletal anchor activity term tracker item “https://github.com/geneontology/go-ontology/issues/19185”^^anyURI
cytoskeletal anchor activity has narrow synonym “cytoskeletal anchor activity”
cytoskeletal anchor activity label “cytoskeletal adaptor activity”

denatured protein binding definition “Binding to a denatured protein.”
- has cross-reference “GOC:mlg”
denatured protein binding comment “Note that this term should not be confused with ‘unfolded protein binding ; GO:0051082’, which usually refers to proteins that have not yet folded into their active states. Denatured proteins once were in their correct functional conformations, but have become incorrectly folded, and often form aggregates.”
denatured protein binding label “denatured protein binding”
denatured protein binding SubClassOf protein binding

denatured protein binding term tracker item “https://github.com/geneontology/go-ontology/issues/30962”^^anyURI
denatured protein binding consider protein folding chaperone
denatured protein binding consider unfolded protein holdase activity
denatured protein binding definition “OBSOLETE. Binding to a denatured protein.”
- has cross-reference “GOC:mlg”
denatured protein binding deprecated true
denatured protein binding comment “The reason for obsoletion is that this binding term should be replaced by an activity term such as protein folding chaperone (GO:0044183) or unfolded protein holdase activity (GO:0140309).”
denatured protein binding label “obsolete denatured protein binding”

development of secondary female sexual characteristics term tracker item “https://github.com/geneontology/go-ontology/issues/31051”^^anyURI
development of secondary female sexual characteristics has exact synonym “development of secondary female sexual characteristics”
development of secondary female sexual characteristics has exact synonym “development of secondary female sexual characteristics, sensu Metazoa”
development of secondary female sexual characteristics definition “The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female mammals, examples include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion.”
- has cross-reference “GOC:ai”
development of secondary female sexual characteristics label “development of animal secondary female sexual characteristics”
development of secondary female sexual characteristics SubClassOf in taxon some Metazoa

development of secondary male sexual characteristics term tracker item “https://github.com/geneontology/go-ontology/issues/31051”^^anyURI
development of secondary male sexual characteristics has exact synonym “development of secondary male sexual characteristics”
development of secondary male sexual characteristics has exact synonym “development of secondary male sexual characteristics, sensu Metazoa”
development of secondary male sexual characteristics definition “The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male mammals, examples include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion.”
- has cross-reference “GOC:ai”
development of secondary male sexual characteristics label “development of animal secondary male sexual characteristics”
development of secondary male sexual characteristics SubClassOf in taxon some Metazoa

development of secondary sexual characteristics term tracker item “https://github.com/geneontology/go-ontology/issues/31051”^^anyURI
development of secondary sexual characteristics has exact synonym “development of secondary sexual characteristics”
development of secondary sexual characteristics has exact synonym “development of secondary sexual characteristics, sensu Metazoa”
development of secondary sexual characteristics definition “The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In mammals, examples include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion.”
- has cross-reference “GOC:ai”
development of secondary sexual characteristics label “development of animal secondary sexual characteristics”
development of secondary sexual characteristics SubClassOf in taxon only Metazoa
development of secondary sexual characteristics SubClassOf only in taxon some Metazoa
development of secondary sexual characteristics SubClassOf in taxon some Metazoa

dibenzofuran 4,4a-dioxygenase activity definition “Catalysis of the reaction: dibenzofuran + NADH + H+ + O2 = 2,2’,3-trihydroxybiphenyl + NAD+.”
- has cross-reference “MetaCyc:R606-RXN”
- has cross-reference “RHEA:42460”

dibenzofuran 4,4a-dioxygenase activity definition “Catalysis of the reaction: dibenzofuran + NADH + H+ + O2 = 2,2’,3-trihydroxybiphenyl + NAD+.”
- has cross-reference “RHEA:42460”

dopamine transport conformsTo chemical_transport.yaml
dopamine transport definition “The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.”
- has cross-reference “GOC:ai”
dopamine transport label “dopamine transport”
dopamine transport EquivalentTo transport and (has primary input some dopaminium(1+))
dopamine transport SubClassOf catecholamine transport
dopamine transport SubClassOf has primary input some dopaminium(1+)

dopamine transport term tracker item “https://github.com/geneontology/go-ontology/issues/31143”^^anyURI
dopamine transport definition “OBSOLETE. The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.”
- has cross-reference “GOC:ai”
dopamine transport deprecated true
dopamine transport comment “The reason for obsoletion is that this is an unnecessary grouping term and annotations should be made to more mechanism/location specific terms.”
dopamine transport label “obsolete dopamine transport”

early endosome to late endosome transport definition “The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs.”
- has cross-reference “ISBN:0815316194”
- has cross-reference “PMID:29980602”

early endosome to late endosome transport term tracker item “https://github.com/geneontology/go-ontology/issues/31923”^^anyURI
early endosome to late endosome transport definition “The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes.”
- has cross-reference “ISBN:0815316194”
- has cross-reference “PMID:29980602”

endocrine hormone secretion term tracker item “https://github.com/geneontology/go-ontology/issues/17084”^^anyURI
endocrine hormone secretion term replaced by hormone secretion
endocrine hormone secretion definition “OBSOLETE. The regulated release of a hormone into the circulatory system.”
- has cross-reference “GOC:dph”
endocrine hormone secretion deprecated true
endocrine hormone secretion comment “The reason for obsoletion is that this term represents fake precision. The distinction between endocrine and other modes of hormone dispersal (paracrine, autocrine) is not always clear-cut, and this term was unevenly used relative to its parent.”
endocrine hormone secretion label “obsolete endocrine hormone secretion”

endoplasmic reticulum signal peptide binding definition “Binding to an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum.”
- has cross-reference “GOC:mah”
endoplasmic reticulum signal peptide binding label “endoplasmic reticulum signal peptide binding”

endoplasmic reticulum signal peptide binding term tracker item “https://github.com/geneontology/go-ontology/issues/31419”^^anyURI
endoplasmic reticulum signal peptide binding has narrow synonym “endoplasmic reticulum signal peptide binding”
endoplasmic reticulum signal peptide binding definition “Binding to an endoplasmic reticulum signal peptide, a short stretch of amino acids found in a protein that acts as a signal to localize the protein to the endoplasmic reticulum.”
- has cross-reference “GOC:mah”
endoplasmic reticulum signal peptide binding label “endoplasmic reticulum signal sequence receptor activity”

endoplasmic reticulum-autophagosome adaptor activity definition “The binding activity of a molecule that brings together an ER membrane and an autophagosome during reticulophagy.”
- has cross-reference “PMID:32735772”

endoplasmic reticulum-autophagosome adaptor activity term tracker item “https://github.com/geneontology/go-ontology/issues/31866”^^anyURI
endoplasmic reticulum-autophagosome adaptor activity definition “The binding activity of a molecule that brings together an ER membrane and an autophagosome membrane during reticulophagy.”
- has cross-reference “PMID:32735772”

endoplasmic reticulum-endosome tether activity definition “The binding activity of a molecule that brings together an endosome and an ER membrane either via membrane lipid binding or by interacting with an endosome protein, to establish and facilitate organelle exchange.”
- has cross-reference “PMID:33124732”

endoplasmic reticulum-endosome tether activity term tracker item “https://github.com/geneontology/go-ontology/issues/31866”^^anyURI
endoplasmic reticulum-endosome tether activity definition “The binding activity of a molecule that brings together an endosome membrane and an ER membrane either via membrane lipid binding or by interacting with an endosome protein, to establish and facilitate organelle exchange.”
- has cross-reference “PMID:33124732”

endoplasmic reticulum-peroxisome tethering term tracker item “https://github.com/geneontology/go-ontology/issues/31879”^^anyURI
endoplasmic reticulum-peroxisome tethering consider peroxisome-endoplasmic reticulum membrane tether activity
endoplasmic reticulum-peroxisome tethering definition “OBSOLETE. The attachment of an endoplasmic reticulum membrane to a peroxisome via molecular tethers that physically bridge the two membranes and attach them to each other.”
- has cross-reference “PMID:28463579”
endoplasmic reticulum-peroxisome tethering deprecated true
endoplasmic reticulum-peroxisome tethering comment “The reason for obsoletion is that this term represents a molecular function rather than a biological process.”
endoplasmic reticulum-peroxisome tethering label “obsolete endoplasmic reticulum-peroxisome tethering”

endoplasmic reticulum-plasma membrane tethering term tracker item “https://github.com/geneontology/go-ontology/issues/31873”^^anyURI
endoplasmic reticulum-plasma membrane tethering consider endoplasmic reticulum localization
endoplasmic reticulum-plasma membrane tethering consider endoplasmic reticulum-plasma membrane adaptor activity
endoplasmic reticulum-plasma membrane tethering definition “OBSOLETE. The attachment of an endoplasmic reticulum membrane to the plasma membrane via molecular tethers.”
- has cross-reference “GOC:dph”
- has cross-reference “PMID:23237950”
- has cross-reference “PMID:26877082”
- has cross-reference “PMID:27875684”
- has cross-reference “GOC:vw”
endoplasmic reticulum-plasma membrane tethering deprecated true
endoplasmic reticulum-plasma membrane tethering comment “This term was obsoleted because it represents a molecular function. Annotations should be migrated to GO:0160214 ‘endoplasmic reticulum-plasma membrane adaptor activity’; the biological process aspect (if any) is captured by GO:0051643 ‘endoplasmic reticulum localization’.”
endoplasmic reticulum-plasma membrane tethering label “obsolete endoplasmic reticulum-plasma membrane tethering”

epinephrine transport term tracker item “https://github.com/geneontology/go-ontology/issues/31143”^^anyURI
epinephrine transport definition “OBSOLETE. The directed movement of epinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- has cross-reference “GOC:jid”
epinephrine transport deprecated true
epinephrine transport comment “The reason for obsoletion is that this is an unnecessary grouping term and annotations should be made to more mechanism/location specific terms.”
epinephrine transport label “obsolete epinephrine transport”

ergothioneine biosynthesis from histidine via hercynylcysteine sulfoxide synthase definition “A biosynthetic process that results in the formation of ergothioneine from histidine via a set of steps including the hercynylcysteine sulfoxide synthase reaction, which converts N-alpha,N-alpha,N-alpha-trimethyl-L-histidine directly to hercynylcysteine sulfoxide.”
- has cross-reference “PMID:24828577”
- has cross-reference “PMID:22209968”
ergothioneine biosynthesis from histidine via hercynylcysteine sulfoxide synthase label “ergothioneine biosynthesis from histidine via hercynylcysteine sulfoxide synthase”
ergothioneine biosynthesis from histidine via hercynylcysteine sulfoxide synthase SubClassOf ergothioneine biosynthetic process
ergothioneine biosynthesis from histidine via hercynylcysteine sulfoxide synthase SubClassOf in taxon some Fungi

ergothioneine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI
ergothioneine metabolic process consider ergothioneine biosynthetic process
ergothioneine metabolic process consider ergothioneine catabolic process
ergothioneine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving ergothioneine, a naturally occurring metabolite of histidine with antioxidant properties.”
- has cross-reference “Wikipedia:Ergothioneine”
ergothioneine metabolic process deprecated true
ergothioneine metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
ergothioneine metabolic process label “obsolete ergothioneine metabolic process”

erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of erythrose 4-phosphate/phosphoenolpyruvate family amino acid.”
- has cross-reference “GOC:pr”
- has cross-reference “GOC:TermGenie”

erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/32000”^^anyURI
erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of an L-amino acid derived from erythrose 4-phosphate and phosphoenolpyruvate (L-phenylalanine, L-tyrosine and L-tryptophan).”
- has cross-reference “GOC:curators”

exocyst definition “A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals.”
- has cross-reference “PMID:9700152”
- has cross-reference “PMID:15292201”
- has cross-reference “PMID:27243008”
- has cross-reference “GOC:cilia”
exocyst SubClassOf capable of part of some vesicle tethering involved in exocytosis

exocyst term tracker item “https://github.com/geneontology/go-ontology/issues/31922”^^anyURI
exocyst definition “A vesicle tethering complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals.”
- has cross-reference “PMID:9700152”
- has cross-reference “PMID:15292201”
- has cross-reference “PMID:27243008”
- has cross-reference “GOC:cilia”

exocytic insertion of neurotransmitter receptor to plasma membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31869”^^anyURI
exocytic insertion of neurotransmitter receptor to plasma membrane definition “OBSOLETE. The exocytic fusion of neurotransmitter receptor-containing vesicles with plasma membrane, resulting in the integration of neurotransmitter receptors into the plasma membrane. This process includes tethering and docking steps that prepare vesicles for fusion.”
- has cross-reference “GOC:bc”
- has cross-reference “PMID:19503082”
- has cross-reference “GOC:aruk”
exocytic insertion of neurotransmitter receptor to plasma membrane deprecated true
exocytic insertion of neurotransmitter receptor to plasma membrane comment “The reason for obsoletion is that the meaning of the term is ambiguous. It was placed under both tethering and docking involved in exocytosis, but it is unclear which part of exocytosis it refers to, and it has not been used.”
exocytic insertion of neurotransmitter receptor to plasma membrane label “obsolete exocytic insertion of neurotransmitter receptor to plasma membrane”

extracellular region comment “Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term ‘extracellular space ; GO:0005615’.”

extracellular region term tracker item “https://github.com/geneontology/go-ontology/issues/31545”^^anyURI
extracellular region comment “Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products at the cell surface, consider annotating to external side of plasma membrane ; GO:0009897.”

ferric-chelate reductase activity definition “Catalysis of the reaction: 2 Fe3+-siderophore + electron donor = 2 Fe2+-siderophore + electron acceptor.”
- has cross-reference “PMID:33559753”
ferric-chelate reductase activity SubClassOf oxidoreductase activity, acting on metal ions

ferric-chelate reductase activity term tracker item “https://github.com/geneontology/go-ontology/issues/27593”^^anyURI
ferric-chelate reductase activity definition “Catalysis of the reaction: 2 Fe3+-chelate + electron donor = 2 Fe2+-chelate + electron acceptor.”
- has cross-reference “PMID:33559753”
ferric-chelate reductase activity SubClassOf ferric iron reductase activity

Class: ferritinophagy
ferritinophagy term tracker item “https://github.com/geneontology/go-ontology/issues/30894”^^anyURI
ferritinophagy created by “dragon-ai-agent”
ferritinophagy creation date “2026-04-29T15:27:39Z”
ferritinophagy has exact synonym “ferritin-specific autophagy”
ferritinophagy has_obo_namespace “biological_process”
ferritinophagy id “GO:7770069”
ferritinophagy definition “The selective degradation of ferritin to release iron by macroautophagy.”
- has cross-reference “PMID:26436293”
- has cross-reference “PMID:38714719”
- has cross-reference “PMID:25327288”
ferritinophagy label “ferritinophagy”
ferritinophagy SubClassOf macroautophagy
ferritinophagy SubClassOf in taxon some Eukaryota

formyl-CoA transferase activity definition “Catalysis of the reaction: formyl-CoA + oxalate = formate + oxalyl-CoA.”
- has cross-reference “RHEA:16545”
- has cross-reference “EC:2.8.3.16”

formyl-CoA transferase activity definition “Catalysis of the reaction: formyl-CoA + oxalate = formate + oxalyl-CoA.”
- has cross-reference “RHEA:16545”

fungal-type cell wall disassembly involved in conjugation with cellular fusion definition “Any fungal-type cell wall disassembly that is involved in conjugation with cellular fusion.”
- has cross-reference “GO_REF:0000060”
- has cross-reference “PMID:25825517”
- has cross-reference “GOC:TermGenie”
fungal-type cell wall disassembly involved in conjugation with cellular fusion label “fungal-type cell wall disassembly involved in conjugation with cellular fusion”

fungal-type cell wall disassembly involved in conjugation with cellular fusion term tracker item “https://github.com/geneontology/go-ontology/issues/31753”^^anyURI
fungal-type cell wall disassembly involved in conjugation with cellular fusion has exact synonym “fungal-type cell wall disassembly involved in conjugation with cellular fusion”
fungal-type cell wall disassembly involved in conjugation with cellular fusion definition “Any fungal-type cell wall disassembly that is involved in conjugation with cellular fusion, where the cell wall is locally disassembled to enable conjugation with cellular fusion.”
- has cross-reference “GO_REF:0000060”
- has cross-reference “PMID:25825517”
- has cross-reference “GOC:TermGenie”
fungal-type cell wall disassembly involved in conjugation with cellular fusion label “mating projection tip cell wall disassembly”

geranylgeranyl diphosphate reductase activity definition “Catalysis of the reaction: (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + 3 NADP = 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + 3 NADPH + 3 H+.”
- has cross-reference “GOC:pz”
- has cross-reference “EC:1.3.1.83”

geranylgeranyl diphosphate reductase activity definition “Catalysis of the reaction: phytyl diphosphate + 3 NADP+ = geranylgeranyl diphosphate + 3 NADPH + 3 H+. This enzyme also catalyzes the reduction of geranylgeranyl-chlorophyll a into phytyl-chlorophyll a.”
- has cross-reference “EC:1.3.1.83”
- has cross-reference “PMID:9492312”
- has cross-reference “RHEA:26229”

geranylgeranyl reductase activity definition “Catalysis of the formation of phytyl group from the stepwise reduction of a geranylgeranyl group.”
- has cross-reference “PMID:9492312”
geranylgeranyl reductase activity label “geranylgeranyl reductase activity”
geranylgeranyl reductase activity SubClassOf oxidoreductase activity

geranylgeranyl reductase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31963”^^anyURI
geranylgeranyl reductase activity term replaced by geranylgeranyl diphosphate reductase activity
geranylgeranyl reductase activity definition “OBSOLETE. Catalysis of the formation of phytyl group from the stepwise reduction of a geranylgeranyl group.”
- has cross-reference “PMID:9492312”
geranylgeranyl reductase activity deprecated true
geranylgeranyl reductase activity comment “This term was obsoleted because it lacked a proper enzyme cross-reference and is equivalent to GO:0102067 ‘geranylgeranyl diphosphate reductase activity’ (EC:1.3.1.83, RHEA:26229), which describes the same reaction (PMID:9492312: reduction of geranylgeranyl diphosphate to phytyl diphosphate, also acting on geranylgeranyl-chlorophyll a).”
geranylgeranyl reductase activity label “obsolete geranylgeranyl reductase activity”

glucarate biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/27059”^^anyURI
glucarate biosynthetic process term replaced by D-glucarate biosynthetic process
glucarate biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of glucarate, the anion of glucaric acid.”
- has cross-reference “ISBN:0198506732”
glucarate biosynthetic process deprecated true
glucarate biosynthetic process comment “This term was obsoleted because it represents the same process as D-glucarate biosynthetic process ; GO:0042837.”
glucarate biosynthetic process label “obsolete glucarate biosynthetic process”

gluconate 5-dehydrogenase activity definition “Catalysis of the reaction: D-gluconate + NADP+ = 5-dehydro-D-gluconate + NADPH + H+.”
- has cross-reference “EC:1.1.1.69”
gluconate 5-dehydrogenase activity label “gluconate 5-dehydrogenase activity”
gluconate 5-dehydrogenase activity SubClassOf gluconate dehydrogenase activity

glutaconate CoA-transferase activity definition “Catalysis of the reaction: acetyl-CoA + (E)-glutaconate = acetate + glutaconyl-1-CoA.”
- has cross-reference “EC:2.8.3.12”

glutaconate CoA-transferase activity definition “Catalysis of the reaction: trans-glutaconate + acetyl-CoA = (2E)-glutaconyl-CoA + acetate.”
- has cross-reference “RHEA:23208”

glutamate-cysteine ligase complex definition “An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine.”
- has cross-reference “PMID:9675072”

glutamate-cysteine ligase complex definition “An enzyme complex that catalyzes the ligation of L-glutamate to L-cysteine, forming gamma-L-glutamyl-L-cysteine.”
- has cross-reference “PMID:9675072”

glycolytic process via Entner-Doudoroff Pathway term tracker item “https://github.com/geneontology/go-ontology/issues/31916”^^anyURI
glycolytic process via Entner-Doudoroff Pathway term replaced by glycolytic process
glycolytic process via Entner-Doudoroff Pathway definition “OBSOLETE. A glycolytic process in which the glucose is catabolized to pyruvate by first entering the Entner-Doudoroff pathway to yield pyruvate and glyceraldehyde-3-phosphate. The glyceraldehyde-3-phosphate is subsequently converted to pyruvate by the core glycolytic enzymes.”
- has cross-reference “GOC:dph”
- has cross-reference “PMID:9657988”
glycolytic process via Entner-Doudoroff Pathway deprecated true
glycolytic process via Entner-Doudoroff Pathway comment “This term was obsoleted because the existing IEA annotations are better captured by the parent term GO:0006096 (glycolytic process); pathway variants are better represented as GO-CAMs rather than as nested ontology terms.”
glycolytic process via Entner-Doudoroff Pathway label “obsolete glycolytic process via Entner-Doudoroff Pathway”

glycoprotein cargo receptor activity term tracker item “https://github.com/geneontology/go-ontology/issues/31038”^^anyURI
glycoprotein cargo receptor activity created by “dragon-ai-agent”
glycoprotein cargo receptor activity definition “Binding specifically to a glycoprotein (cargo) to deliver it to a transport vesicle. Glycoprotein cargo receptors span membranes, binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit the cargo molecules to nascent vesicles.”
- has cross-reference “PMID:41203586”
glycoprotein cargo receptor activity label “glycoprotein cargo receptor activity”
glycoprotein cargo receptor activity SubClassOf cargo receptor activity

glycoprotein cargo receptor activity term tracker item “https://github.com/geneontology/go-ontology/issues/31948”^^anyURI
glycoprotein cargo receptor activity term replaced by cargo receptor activity
glycoprotein cargo receptor activity definition “OBSOLETE. Binding specifically to a glycoprotein (cargo) to deliver it to a transport vesicle. Glycoprotein cargo receptors span membranes, binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit the cargo molecules to nascent vesicles.”
- has cross-reference “PMID:41203586”
glycoprotein cargo receptor activity deprecated true
glycoprotein cargo receptor activity comment “The reason for obsoletion is that this term was added in error. Most vesicle cargo are glycoproteins, so classifying cargo receptors by glycoprotein substrate introduces an additional, unhelpful axis of classification. Cargo receptor activities should instead be organized by transport domain (i.e., the vesicles they connect cargo to), with substrates captured via has_input.”
glycoprotein cargo receptor activity label “obsolete glycoprotein cargo receptor activity”

histamine oxidase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31964”^^anyURI

hydroxyquinol 1,2-dioxygenase activity term replaced by 4-hydroxycatechol 1,2-dioxygenase activity
hydroxyquinol 1,2-dioxygenase activity definition “OBSOLETE. Catalysis of the reaction: benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate + 2 H+.”
- has cross-reference “RHEA:19441”
hydroxyquinol 1,2-dioxygenase activity deprecated true
hydroxyquinol 1,2-dioxygenase activity comment “The reason for obsoletion is that this term described a sub-reaction of the complete two-step reaction represented by GO:0047074. The second step (non-enzymatic conversion of 3-hydroxy-cis,cis-muconate to maleylacetate) is not catalyzed separately, so this term is equivalent to GO:0047074 hydroxyquinol 1,2-dioxygenase activity.”
hydroxyquinol 1,2-dioxygenase activity label “obsolete hydroxyquinol 1,2-dioxygenase activity”

hypoxanthine oxidase activity definition “Catalysis of the reaction: hypoxanthine + H2O + O2 = xanthine + H2O2.”
- has cross-reference “GOC:mah”
- has cross-reference “GOC:pde”

immaterial anatomical entity definition “Anatomical entity that has no mass.”

induction of conjugation with cellular fusion definition “The process in which a cell initiates conjugation with cellular fusion. Conjugation with cellular fusion is the process that results in the union of cellular and genetic information from compatible mating types.”
- has cross-reference “GOC:dph”
- has cross-reference “GOC:tb”
induction of conjugation with cellular fusion label “induction of conjugation with cellular fusion”
induction of conjugation with cellular fusion SubClassOf positive regulation of conjugation with cellular fusion
induction of conjugation with cellular fusion SubClassOf in taxon some Fungi or Dictyostelium

induction of conjugation with cellular fusion term tracker item “https://github.com/geneontology/go-ontology/issues/31335”^^anyURI
induction of conjugation with cellular fusion term replaced by positive regulation of conjugation with cellular fusion
induction of conjugation with cellular fusion definition “OBSOLETE. The process in which a cell initiates conjugation with cellular fusion. Conjugation with cellular fusion is the process that results in the union of cellular and genetic information from compatible mating types.”
- has cross-reference “GOC:dph”
- has cross-reference “GOC:tb”
induction of conjugation with cellular fusion deprecated true
induction of conjugation with cellular fusion comment “This term was obsoleted because it is a pre-composed term that should be represented as a GO-CAM model.”
induction of conjugation with cellular fusion label “obsolete induction of conjugation with cellular fusion”

intracellular cysteine homeostasis definition “A homeostatic process involved in the maintenance of a steady state level of cysteine within a cell.”
- has cross-reference “PMID:19955263”

intracellular cysteine homeostasis definition “A homeostatic process involved in the maintenance of a steady state level of L-cysteine within a cell.”
- has cross-reference “PMID:19955263”

ketogluconate biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31978”^^anyURI
ketogluconate biosynthetic process term replaced by keto-D-gluconate biosynthetic process
ketogluconate biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group.”
- has cross-reference “ISBN:0198506732”
ketogluconate biosynthetic process deprecated true
ketogluconate biosynthetic process comment “This term was obsoleted because it is an unnecessary grouping term.”
ketogluconate biosynthetic process label “obsolete ketogluconate biosynthetic process”

ketogluconate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31978”^^anyURI
ketogluconate catabolic process term replaced by keto-D-gluconate catabolic process
ketogluconate catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group.”
- has cross-reference “ISBN:0198506732”
ketogluconate catabolic process deprecated true
ketogluconate catabolic process comment “This term was obsoleted because it represents an unnecessary grouping term.”
ketogluconate catabolic process label “obsolete ketogluconate catabolic process”

ketone body biosynthetic process definition “The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA.”
- has cross-reference “ISBN:0198506732”
ketone body biosynthetic process SubClassOf ketone body metabolic process

ketone body biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31806”^^anyURI
ketone body biosynthetic process has cross-reference “MetaCyc:PWY66-367”
ketone body biosynthetic process has exact synonym “ketogenesis”
ketone body biosynthetic process definition “The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA.”
- has cross-reference “MetaCyc:PWY66-367”

ketone body catabolic process definition “The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA.”
- has cross-reference “ISBN:0198506732”
ketone body catabolic process SubClassOf ketone body metabolic process

ketone body catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31806”^^anyURI
ketone body catabolic process definition “The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA.”
- has cross-reference “MetaCyc:PWY66-367”

ketone body metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31806”^^anyURI
ketone body metabolic process definition “OBSOLETE. The chemical reactions and pathways involving ketone body.”
- has cross-reference “GOC:pr”
- has cross-reference “GOC:TermGenie”
ketone body metabolic process deprecated true
ketone body metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
ketone body metabolic process label “obsolete ketone body metabolic process”

lysine 2-monooxygenase activity label “lysine 2-monooxygenase activity”

malonate CoA-transferase activity definition “Catalysis of the reaction: acetyl-CoA + malonate = acetate + malonyl-CoA.”
- has cross-reference “EC:2.8.3.3”
- has cross-reference “RHEA:18817”

malonate CoA-transferase activity definition “Catalysis of the reaction: acetyl-CoA + malonate = acetate + malonyl-CoA.”
- has cross-reference “RHEA:18817”

material anatomical entity definition “Anatomical entity that has mass.”

mating projection actin fusion focus definition “A focus at the mating projection tip where the cell wall is degraded during conjugation with cellular fusion. Actin filaments form an aster-like structure from this location.”
- has cross-reference “PMID:25825517”

mating projection actin fusion focus term tracker item “https://github.com/geneontology/go-ontology/issues/31774”^^anyURI
mating projection actin fusion focus definition “A focus at the mating projection tip where the cell wall is degraded during cytogamy. Actin filaments form an aster-like structure from this location.”
- has cross-reference “PMID:25825517”

membrane-membrane adaptor activity definition “The binding activity of a molecule that brings together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle.”
- has cross-reference “GOC:curators”

membrane-membrane adaptor activity definition “The binding activity of a molecule that brings together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex, vesicle or organelle.”
- has cross-reference “GOC:curators”

migrasome SubClassOf in taxon only [Vertebrata ](http://purl.obolibrary.org/obo/NCBITaxon_7742)
migrasome SubClassOf only in taxon some [Vertebrata ](http://purl.obolibrary.org/obo/NCBITaxon_7742)
migrasome SubClassOf in taxon some [Vertebrata ](http://purl.obolibrary.org/obo/NCBITaxon_7742)

mitochondrial cysteinyl-tRNA aminoacylation definition “The process of coupling cysteine to cysteinyl-tRNA in a mitochondrion, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- has cross-reference “GOC:mah”
- has cross-reference “GOC:mcc”

mitochondrial cysteinyl-tRNA aminoacylation definition “The process of coupling L-cysteine to cysteinyl-tRNA in a mitochondrion, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- has cross-reference “GOC:mah”
- has cross-reference “GOC:mcc”

mitochondrial disulfide relay system definition “A protein folding process that facilitates the import of a subset of soluble proteins into mitochondrial intermembrane space via disulfide bond formation.”
- has cross-reference “PMID:37159021”
- has cross-reference “PMID:32936885”
mitochondrial disulfide relay system label “mitochondrial disulfide relay system”
mitochondrial disulfide relay system SubClassOf protein folding
mitochondrial disulfide relay system SubClassOf part of some protein import into mitochondrial intermembrane space

mitochondrial disulfide relay system term tracker item “https://github.com/geneontology/go-ontology/issues/31711”^^anyURI
mitochondrial disulfide relay system has exact synonym “mitochondrial disulfide relay system”
mitochondrial disulfide relay system has narrow synonym “CHCHD4/Mia40-dependent import”
mitochondrial disulfide relay system definition “The import of small cysteine-containing proteins from the cytosol across the outer mitochondrial membrane via the TOM complex driven by oxidative folding.”
- has cross-reference “PMID:37159021”
- has cross-reference “PMID:32936885”
mitochondrial disulfide relay system label “protein import into the intermembrane space via the disulfide relay system”
mitochondrial disulfide relay system SubClassOf protein import into mitochondrial intermembrane space
mitochondrial disulfide relay system SubClassOf in taxon some cellular organisms

mitochondrial gene expression definition “The process in which a mitochondrial gene’s sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.”
- has cross-reference “PMID:27058308”

mitochondrial gene expression term tracker item “https://github.com/geneontology/go-ontology/issues/31659”^^anyURI
mitochondrial gene expression definition “The process of transcribing and translating the mitochondrial genome (mtDNA) to produce at least a subset of oxidative phosphorylation (OXPHOS) proteins, 2 rRNAs, and mitochondrial tRNAs, which are critical for ATP production. Protein maturation is included when required to form an active form of a product from an inactive precursor form.”
- has cross-reference “PMID:27058308”
- has cross-reference “PMID:38117001”
- has cross-reference “PMID:31861673”

mitochondrial tRNA wobble position uridine thiolation definition “The process in which a uridine residue at position 34 in the anticodon of a mitochondrial tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.”
- has cross-reference “PMID:15509579”

mitochondrial tRNA wobble position uridine thiolation definition “The process in which a uridine residue at position 34 in the anticodon of a mitochondrial tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from L-cysteine to position C2 by several steps.”
- has cross-reference “PMID:15509579”

mitochondrion autophagosome adaptor activity definition “The binding activity of a molecule that brings together a mitochondrial membrane and an autophagosome during mitophagy.”
- has cross-reference “PMID:33138913”

mitochondrion autophagosome adaptor activity term tracker item “https://github.com/geneontology/go-ontology/issues/31866”^^anyURI
mitochondrion autophagosome adaptor activity definition “The binding activity of a molecule that brings together a mitochondrial membrane and an autophagosome membrane during mitophagy.”
- has cross-reference “PMID:33138913”

mitochondrion-endoplasmic reticulum membrane tether activity definition “The binding activity of a molecule that brings together a mitochondrion and an ER membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion.”
- has cross-reference “PMID:19556461”
- has cross-reference “PMID:27875684”

mitochondrion-endoplasmic reticulum membrane tether activity term tracker item “https://github.com/geneontology/go-ontology/issues/31866”^^anyURI
mitochondrion-endoplasmic reticulum membrane tether activity definition “The binding activity of a molecule that brings together a mitochondrial outer membrane and an ER membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion.”
- has cross-reference “PMID:19556461”
- has cross-reference “PMID:27875684”

mitochondrion-endoplasmic reticulum membrane tethering term tracker item “https://github.com/geneontology/go-ontology/issues/31875”^^anyURI
mitochondrion-endoplasmic reticulum membrane tethering consider mitochondrion-endoplasmic reticulum membrane tether activity
mitochondrion-endoplasmic reticulum membrane tethering definition “OBSOLETE. The attachment of a mitochondrion and an endoplasmic reticulum via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles.”
- has cross-reference “PMID:19556461”
- has cross-reference “PMID:27875684”
mitochondrion-endoplasmic reticulum membrane tethering deprecated true
mitochondrion-endoplasmic reticulum membrane tethering comment “The reason for obsoletion is that this term represents a molecular function. Consider reannotating to GO:0140474 ‘mitochondrion-endoplasmic reticulum membrane tether activity’.”
mitochondrion-endoplasmic reticulum membrane tethering label “obsolete mitochondrion-endoplasmic reticulum membrane tethering”

mitochondrion-plasma membrane adaptor activity definition “The binding activity of a molecule that brings together a mitochondrion and a plasma membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion.”
- has cross-reference “PMID:31582398”
mitochondrion-plasma membrane adaptor activity SubClassOf protein-membrane adaptor activity

mitochondrion-plasma membrane adaptor activity term tracker item “https://github.com/geneontology/go-ontology/issues/31866”^^anyURI
mitochondrion-plasma membrane adaptor activity definition “The binding activity of a molecule that brings together a mitochondrial outer membrane and a plasma membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion.”
- has cross-reference “PMID:31582398”
mitochondrion-plasma membrane adaptor activity SubClassOf membrane-membrane adaptor activity

molecular_function definition “A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.”

monoamine transport conformsTo chemical_transport.yaml
monoamine transport definition “The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- has cross-reference “GOC:mah”
monoamine transport label “monoamine transport”
monoamine transport EquivalentTo transport and (has primary input some monoamine)
monoamine transport SubClassOf nitrogen compound transport
monoamine transport SubClassOf has primary input some monoamine

monoamine transport term tracker item “https://github.com/geneontology/go-ontology/issues/31143”^^anyURI
monoamine transport definition “OBSOLETE. The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- has cross-reference “GOC:mah”
monoamine transport deprecated true
monoamine transport comment “The reason for obsoletion is that this is an unnecessary grouping term and annotations should be made to more mechanism/location specific terms.”
monoamine transport label “obsolete monoamine transport”

negative regulation of L-dopa biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31703”^^anyURI
negative regulation of L-dopa biosynthetic process definition “OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of L-dopa biosynthetic process.”
- has cross-reference “GO_REF:0000058”
- has cross-reference “GOC:PARL”
- has cross-reference “GOC:bf”
- has cross-reference “GOC:TermGenie”
negative regulation of L-dopa biosynthetic process deprecated true
negative regulation of L-dopa biosynthetic process comment “This term was obsoleted because there is no evidence that this process exists.”
negative regulation of L-dopa biosynthetic process label “obsolete negative regulation of L-dopa biosynthetic process”

negative regulation of butyryl-CoA catabolic process to butanol term tracker item “https://github.com/geneontology/go-ontology/issues/31933”^^anyURI
negative regulation of butyryl-CoA catabolic process to butanol definition “OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of butyryl-CoA catabolic process to butanol.”
- has cross-reference “GOC:mengo_curators”
- has cross-reference “GOC:TermGenie”
negative regulation of butyryl-CoA catabolic process to butanol deprecated true
negative regulation of butyryl-CoA catabolic process to butanol comment “This term was obsoleted because it is an unnecessary grouping term.”
negative regulation of butyryl-CoA catabolic process to butanol label “obsolete negative regulation of butyryl-CoA catabolic process to butanol”

negative regulation of butyryl-CoA catabolic process to butyrate term tracker item “https://github.com/geneontology/go-ontology/issues/31933”^^anyURI
negative regulation of butyryl-CoA catabolic process to butyrate definition “OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of butyryl-CoA catabolic process to butyrate.”
- has cross-reference “GOC:mengo_curators”
- has cross-reference “GOC:TermGenie”
negative regulation of butyryl-CoA catabolic process to butyrate deprecated true
negative regulation of butyryl-CoA catabolic process to butyrate comment “This term was obsoleted because it is an unnecessary grouping term.”
negative regulation of butyryl-CoA catabolic process to butyrate label “obsolete negative regulation of butyryl-CoA catabolic process to butyrate”

negative regulation of nitric oxide mediated signal transduction term tracker item “https://github.com/geneontology/go-ontology/issues/26613”^^anyURI
negative regulation of nitric oxide mediated signal transduction term replaced by negative regulation of nitric oxide-cGMP mediated signal transduction
negative regulation of nitric oxide mediated signal transduction definition “OBSOLETE. Any process that decreases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO).”
- has cross-reference “GOC:dph”
- has cross-reference “GOC:tb”
- has cross-reference “GOC:BHF”
negative regulation of nitric oxide mediated signal transduction deprecated true
negative regulation of nitric oxide mediated signal transduction comment “The reason for obsoletion is that this term has been inconsistently used and NO signaling proceeds via cGMP, so the more specific replacement term is preferred.”
negative regulation of nitric oxide mediated signal transduction label “obsolete negative regulation of nitric oxide mediated signal transduction”

nitric oxide dioxygenase NAD(P)H activity label “nitric oxide dioxygenase NAD(P)H activity”

nitric oxide dioxygenase NAD(P)H activity label “nitric oxide dioxygenase [NAD(P)H] activity”

nitric oxide mediated signal transduction has exact synonym “NO mediated signal transduction”
nitric oxide mediated signal transduction has exact synonym “NO-mediated signal transduction”
nitric oxide mediated signal transduction has exact synonym “nitric oxide-mediated signal transduction”
nitric oxide mediated signal transduction has exact synonym “nitric oxide signaling”
- has cross-reference “GOC:bf”
nitric oxide mediated signal transduction definition “An intracellular signaling cassette that starts with production of nitric oxide, detection by receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and ends with the activation of downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.”
- has cross-reference “PMID:21549190”
- has cross-reference “GOC:jl”
nitric oxide mediated signal transduction label “nitric oxide mediated signal transduction”
nitric oxide mediated signal transduction SubClassOf intracellular signaling cassette
nitric oxide mediated signal transduction SubClassOf has participant some nitric oxide

nitric oxide mediated signal transduction term tracker item “https://github.com/geneontology/go-ontology/issues/26613”^^anyURI
nitric oxide mediated signal transduction term replaced by nitric oxide-cGMP-mediated signaling
nitric oxide mediated signal transduction definition “OBSOLETE. An intracellular signaling cassette that starts with production of nitric oxide, detection by receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and ends with the activation of downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.”
- has cross-reference “PMID:21549190”
- has cross-reference “GOC:jl”
nitric oxide mediated signal transduction deprecated true
nitric oxide mediated signal transduction comment “The reason for obsoletion is that this term has been inconsistently used and NO signaling proceeds via cGMP, so the more specific replacement term is preferred.”
nitric oxide mediated signal transduction label “obsolete nitric oxide mediated signal transduction”

norepinephrine transport conformsTo chemical_transport.yaml
norepinephrine transport has exact synonym “levarterenol transport”
norepinephrine transport has exact synonym “noradrenaline transport”
norepinephrine transport definition “The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.”
- has cross-reference “GOC:ai”
- has cross-reference “ISBN:0198506732”
norepinephrine transport label “norepinephrine transport”
norepinephrine transport EquivalentTo transport and (has primary input some (R)-noradrenaline(1+))
norepinephrine transport SubClassOf organic cation transport
norepinephrine transport SubClassOf catecholamine transport
norepinephrine transport SubClassOf has primary input some (R)-noradrenaline(1+)

norepinephrine transport term tracker item “https://github.com/geneontology/go-ontology/issues/31143”^^anyURI
norepinephrine transport definition “OBSOLETE. The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.”
- has cross-reference “GOC:ai”
- has cross-reference “ISBN:0198506732”
norepinephrine transport deprecated true
norepinephrine transport comment “The reason for obsoletion is that this is an unnecessary grouping term and annotations should be made to more mechanism/location specific terms.”
norepinephrine transport label “obsolete norepinephrine transport”

nucleotidase activity term tracker item “https://github.com/geneontology/go-ontology/issues/29439”^^anyURI
nucleotidase activity definition “Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate.”
- has cross-reference “PMID:22555564”
- has cross-reference “PMID:12947102”

obsolete glutamic-type endopeptidase activity definition “OBSOLETE. Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad.”
- has cross-reference “https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE”
- has cross-reference “GOC:mah”
- has cross-reference “https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE”
obsolete glutamic-type endopeptidase activity deprecated true
obsolete glutamic-type endopeptidase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete glutamic-type endopeptidase activity label “obsolete glutamic-type endopeptidase activity”

obsolete glutamic-type endopeptidase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31893”^^anyURI
obsolete glutamic-type endopeptidase activity definition “Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad.”
- has cross-reference “https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE”
- has cross-reference “GOC:mah”
- has cross-reference “https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE”
obsolete glutamic-type endopeptidase activity comment “Unobsoleted, since similar terms exist.”
obsolete glutamic-type endopeptidase activity label “glutamic-type endopeptidase activity”
obsolete glutamic-type endopeptidase activity SubClassOf endopeptidase activity
obsolete glutamic-type endopeptidase activity SubClassOf glutamic-type peptidase activity

old cell tip after activation of bipolar cell growth definition “A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs, which is part of a cell that has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures.”
- has cross-reference “GOC:expert_jd”
- has cross-reference “GOC:mah”
old cell tip after activation of bipolar cell growth label “old cell tip after activation of bipolar cell growth”
old cell tip after activation of bipolar cell growth SubClassOf old growing cell tip
old cell tip after activation of bipolar cell growth SubClassOf in taxon some cellular organisms

old cell tip after activation of bipolar cell growth term tracker item “https://github.com/geneontology/go-ontology/issues/31746”^^anyURI
old cell tip after activation of bipolar cell growth term replaced by old growing cell tip
old cell tip after activation of bipolar cell growth definition “OBSOLETE. A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs, which is part of a cell that has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures.”
- has cross-reference “GOC:expert_jd”
- has cross-reference “GOC:mah”
old cell tip after activation of bipolar cell growth deprecated true
old cell tip after activation of bipolar cell growth comment “This term was obsoleted because the parent process, activation of bipolar cell growth, GO:0051519, was obsoleted.”
old cell tip after activation of bipolar cell growth label “obsolete old cell tip after activation of bipolar cell growth”

organic acid biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31816”^^anyURI
organic acid biosynthetic process term replaced by metabolic process
organic acid biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.”
- has cross-reference “ISBN:0198506732”
organic acid biosynthetic process deprecated true
organic acid biosynthetic process comment “The reason for obsoletion is that this term was an unnecessary grouping term.”
organic acid biosynthetic process label “obsolete organic acid biosynthetic process”

organic acid catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31816”^^anyURI
organic acid catabolic process term replaced by metabolic process
organic acid catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.”
- has cross-reference “ISBN:0198506732”
organic acid catabolic process deprecated true
organic acid catabolic process comment “The reason for obsoletion is that this term was an unnecessary grouping term.”
organic acid catabolic process label “obsolete organic acid catabolic process”

organic acid metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31816”^^anyURI
organic acid metabolic process term replaced by metabolic process
organic acid metabolic process definition “OBSOLETE. The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.”
- has cross-reference “ISBN:0198506732”
organic acid metabolic process deprecated true
organic acid metabolic process comment “The reason for obsoletion is that this term was an unnecessary grouping term.”
organic acid metabolic process label “obsolete organic acid metabolic process”

organic acid phosphorylation term tracker item “https://github.com/geneontology/go-ontology/issues/31816”^^anyURI
organic acid phosphorylation term replaced by metabolic process
organic acid phosphorylation definition “OBSOLETE. The process of introducing one or more phosphate groups into an organic acid.”
- has cross-reference “GOC:mah”
organic acid phosphorylation deprecated true
organic acid phosphorylation comment “The reason for obsoletion is that this term was an unnecessary grouping term.”
organic acid phosphorylation label “obsolete organic acid phosphorylation”

organic anion transport conformsTo chemical_transport.yaml
organic anion transport definition “The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.”
- has cross-reference “GOC:ai”
- has cross-reference “GOC:krc”
organic anion transport label “organic anion transport”
organic anion transport EquivalentTo transport and (has primary input some organic anion)
organic anion transport SubClassOf transport
organic anion transport SubClassOf has primary input some organic anion

organic anion transport term tracker item “https://github.com/geneontology/go-ontology/issues/30715”^^anyURI
organic anion transport term replaced by transmembrane transport
organic anion transport definition “OBSOLETE. The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.”
- has cross-reference “GOC:ai”
- has cross-reference “GOC:krc”
organic anion transport deprecated true
organic anion transport comment “The reason for obsoletion is that this term was an unnecessary grouping term.”
organic anion transport label “obsolete organic anion transport”

organic cation transport conformsTo chemical_transport.yaml
organic cation transport definition “The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage.”
- has cross-reference “GOC:ai”
organic cation transport label “organic cation transport”
organic cation transport EquivalentTo transport and (has primary input some organic cation)
organic cation transport SubClassOf transport
organic cation transport SubClassOf has primary input some organic cation

organic cation transport term tracker item “https://github.com/geneontology/go-ontology/issues/30715”^^anyURI
organic cation transport term replaced by transmembrane transport
organic cation transport definition “OBSOLETE. The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage.”
- has cross-reference “GOC:ai”
organic cation transport deprecated true
organic cation transport comment “The reason for obsoletion is that this term was an unnecessary grouping term.”
organic cation transport label “obsolete organic cation transport”

oxygen evolving activity relatedMatch RXN0-5265
oxygen evolving activity definition “Catalysis of the reaction: 2 H2O = O2 + 4 H+ + 4 e-. The evolution of oxygen from oxidizing water is carried out by the oxygen evolving complex in photosystem II of plants. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle.”
- has cross-reference “GOC:syr”
- has cross-reference “PMID:17091926”
- has cross-reference “GOC:kd”
- has cross-reference “PMID:7948862”
oxygen evolving activity SubClassOf oxidoreductase activity

oxygen evolving activity term tracker item “https://github.com/geneontology/go-ontology/issues/31592”^^anyURI
oxygen evolving activity definition “Catalysis of the reaction: 2 a plastoquinone + 4 hnu + 2 H2O = 2 a plastoquinol + O2. The evolution of oxygen from oxidizing water is carried out by the oxygen evolving complex in photosystem II of plants.”
- has cross-reference “PMID:17091926”
- has cross-reference “RHEA:36359”
- has cross-reference “PMID:7948862”
oxygen evolving activity SubClassOf oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor

oxygen-dependent protoporphyrinogen oxidase activity label “oxygen-dependent protoporphyrinogen oxidase activity”

Class: p24 cargo receptor complex
p24 cargo receptor complex term tracker item “https://github.com/geneontology/go-ontology/issues/31295”^^anyURI
p24 cargo receptor complex created by “dragon-ai-agent”
p24 cargo receptor complex creation date “2026-05-06T17:36:35Z”
p24 cargo receptor complex has exact synonym “p24 complex”
p24 cargo receptor complex has_obo_namespace “cellular_component”
p24 cargo receptor complex has_related_synonym “Emp24-Erv25 complex”
p24 cargo receptor complex has_related_synonym “TMED complex”
p24 cargo receptor complex has_related_synonym “p24 family complex”
p24 cargo receptor complex id “GO:7770070”
p24 cargo receptor complex definition “A conserved, hetero-oligomeric (often tetrameric) cycling ER-Golgi protein complex that selectively recruits secretory cargo, especially GPI-anchored proteins, into COPII vesicles and helps maintain early secretory pathway organization. A functional p24 complex typically contains one member of each subfamily of p24 proteins, alpha, beta, gamma and delta.”
- has cross-reference “PMID:19566487”
- has cross-reference “PMID:26224213”
- has cross-reference “PMID:27569046”
- has cross-reference “PMID:32456004”
- has cross-reference “PMID:34647572”
p24 cargo receptor complex label “p24 cargo receptor complex”
p24 cargo receptor complex SubClassOf cargo receptor complex
p24 cargo receptor complex SubClassOf capable of part of some endoplasmic reticulum to Golgi vesicle-mediated transport

para-aminobenzoic acid metabolic process consider 4-aminobenzoate biosynthetic process
para-aminobenzoic acid metabolic process definition “OBSOLETE. The chemical reactions and pathways involving para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins.”
- has cross-reference “PMID:11960743”
para-aminobenzoic acid metabolic process deprecated true
para-aminobenzoic acid metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
para-aminobenzoic acid metabolic process label “obsolete para-aminobenzoic acid metabolic process”

peroxisome targeting sequence binding definition “Binding to a peroxisomal targeting sequence, a sequence of amino acids within a protein that acts as a signal for the localization of a protein into the peroxisome.”
- has cross-reference “GOC:mah”
- has cross-reference “ISBN:0879693568”
peroxisome targeting sequence binding label “peroxisome targeting sequence binding”

peroxisome targeting sequence binding term tracker item “https://github.com/geneontology/go-ontology/issues/31419”^^anyURI
peroxisome targeting sequence binding has narrow synonym “peroxisome targeting sequence binding”
peroxisome targeting sequence binding definition “Binding to a peroxisomal targeting sequence, a short stretch of amino acids found in a protein that acts as a signal to localize the protein to the peroxisome.”
- has cross-reference “PMID:20659419”
peroxisome targeting sequence binding label “peroxisome signal sequence receptor activity”

peroxisome-chloroplast membrane tethering term tracker item “https://github.com/geneontology/go-ontology/issues/31877”^^anyURI
peroxisome-chloroplast membrane tethering consider peroxisome-chloroplast membrane tether activity
peroxisome-chloroplast membrane tethering definition “OBSOLETE. The attachment of a peroxisome to a chloroplast via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles.”
- has cross-reference “PMID:17215364”
peroxisome-chloroplast membrane tethering deprecated true
peroxisome-chloroplast membrane tethering comment “This term was made obsolete because it represents a molecular function rather than a biological process.”
peroxisome-chloroplast membrane tethering label “obsolete peroxisome-chloroplast membrane tethering”

peroxisome-endoplasmic reticulum membrane tether activity definition “The binding activity of a molecule that brings together a peroxisome and an ER membrane, either via membrane lipid binding or by interacting with a membrane protein.”
- has cross-reference “PMID:39271061”

peroxisome-endoplasmic reticulum membrane tether activity term tracker item “https://github.com/geneontology/go-ontology/issues/31866”^^anyURI
peroxisome-endoplasmic reticulum membrane tether activity definition “The binding activity of a molecule that brings together a peroxisome membrane and an ER membrane, either via membrane lipid binding or by interacting with a membrane protein.”
- has cross-reference “PMID:39271061”

peroxisome-mitochondrion membrane tether activity definition “The binding activity of a molecule that brings together the peroxisome and the mitochondrial outer membrane, establishing the localization of the peroxisome close to the mitochondrion.”
- has cross-reference “PMID:29720625”
- has cross-reference “PMID:38669296”
peroxisome-mitochondrion membrane tether activity SubClassOf protein-membrane adaptor activity

peroxisome-mitochondrion membrane tether activity term tracker item “https://github.com/geneontology/go-ontology/issues/31866”^^anyURI
peroxisome-mitochondrion membrane tether activity definition “The binding activity of a molecule that brings together the peroxisome membrane and the mitochondrial outer membrane, establishing the localization of the peroxisome close to the mitochondrion.”
- has cross-reference “PMID:29720625”
- has cross-reference “PMID:38669296”
peroxisome-mitochondrion membrane tether activity SubClassOf membrane-membrane adaptor activity

pheophorbide a oxygenase activity definition “Catalysis of the reaction: pheophorbide a + reduced ferredoxin + 2 O2 = red chlorophyll catabolite + oxidized ferredoxin + H2O.”
- has cross-reference “PMID:14657372”
pheophorbide a oxygenase activity SubClassOf oxidoreductase activity, acting on iron-sulfur proteins as donors

phosphoglucomutase (glucose-cofactor) activity term tracker item “https://github.com/geneontology/go-ontology/issues/31927”^^anyURI
phosphoglucomutase (glucose-cofactor) activity definition “OBSOLETE. Catalysis of the reaction: glucose-1-phosphate = glucose-6-phosphate; using D-glucose as a cofactor.”
- has cross-reference “EC:5.4.2.5”
phosphoglucomutase (glucose-cofactor) activity deprecated true
phosphoglucomutase (glucose-cofactor) activity comment “The reason for obsoletion is that this activity (EC:5.4.2.5) is not known to be catalyzed by any gene product. RHEA:23536, which is shared between EC:5.4.2.2 and EC:5.4.2.5, actually represents the EC:5.4.2.2 mechanism (alpha-D-glucose 1,6-bisphosphate-dependent) and remains as the exactMatch xref on the parent term GO:0004614 (phosphoglucomutase activity). EC:5.4.2.5 is retained on this obsolete term as the valid external reference.”
phosphoglucomutase (glucose-cofactor) activity label “obsolete phosphoglucomutase (glucose-cofactor) activity”

phthalate 4,5-dioxygenase activity definition “Catalysis of the reaction: H+ + NADH + O2 + phthalate = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD+.”
- has cross-reference “EC:1.14.12.7”
- has cross-reference “RHEA:17489”

phthalate 4,5-dioxygenase activity definition “Catalysis of the reaction: phthalate + NADH + O2 + H+ = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD+.”
- has cross-reference “RHEA:17489”

piperitol synthase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31969”^^anyURI
piperitol synthase activity definition “Catalysis of the reaction: (+)-pinoresinol + reduced [NADPH–hemoprotein reductase] + O2 = (+)-piperitol + oxidized [NADPH–hemoprotein reductase] + 2 H2O + H+. Also catalyzes the synthesis of (+)-sesamin from (+)-piperitol.”
- has cross-reference “PMID:16785429”
- has cross-reference “EC:1.14.19.74”
piperitol synthase activity SubClassOf oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

plant anatomical entity definition “An anatomical entity that is or was part of a plant.”

podosome term tracker item “https://github.com/geneontology/go-ontology/issues/20443”^^anyURI
podosome SubClassOf actin-based cell projection

polyamine acetylation definition “The modification of polyamines by addition of acetyl groups.”
- has cross-reference “GOC:mlg”
polyamine acetylation label “polyamine acetylation”
polyamine acetylation SubClassOf polyamine metabolic process

polyamine acetylation term tracker item “https://github.com/geneontology/go-ontology/issues/31741”^^anyURI
polyamine acetylation consider diamine N-acetyltransferase activity
polyamine acetylation consider polyamine catabolic process
polyamine acetylation definition “OBSOLETE. The modification of polyamines by addition of acetyl groups.”
- has cross-reference “GOC:mlg”
polyamine acetylation deprecated true
polyamine acetylation comment “The reason for obsoletion is that this term represents a molecular function.”
polyamine acetylation label “obsolete polyamine acetylation”

polyamine deacetylation term tracker item “https://github.com/geneontology/go-ontology/issues/31741”^^anyURI
polyamine deacetylation consider polyamine catabolic process
polyamine deacetylation consider deacetylase activity
polyamine deacetylation definition “OBSOLETE. The modification of acetylpolyamine by the removal of acetyl groups.”
- has cross-reference “PMID:28516954”
polyamine deacetylation deprecated true
polyamine deacetylation comment “The reason for obsoletion is that this term represents a molecular function.”
polyamine deacetylation label “obsolete polyamine deacetylation”

positive regulation of L-dopa biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31703”^^anyURI
positive regulation of L-dopa biosynthetic process definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of L-dopa biosynthetic process.”
- has cross-reference “GO_REF:0000058”
- has cross-reference “GOC:PARL”
- has cross-reference “GOC:bf”
- has cross-reference “PMID:16731528”
- has cross-reference “GOC:TermGenie”
positive regulation of L-dopa biosynthetic process deprecated true
positive regulation of L-dopa biosynthetic process comment “This term was obsoleted because there is no evidence that this process exists.”
positive regulation of L-dopa biosynthetic process label “obsolete positive regulation of L-dopa biosynthetic process”

positive regulation of butyryl-CoA catabolic process to butanol term tracker item “https://github.com/geneontology/go-ontology/issues/31933”^^anyURI
positive regulation of butyryl-CoA catabolic process to butanol definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of butyryl-CoA catabolic process to butanol.”
- has cross-reference “GOC:mengo_curators”
- has cross-reference “GOC:TermGenie”
positive regulation of butyryl-CoA catabolic process to butanol deprecated true
positive regulation of butyryl-CoA catabolic process to butanol comment “This term was obsoleted because it is an unnecessary grouping term.”
positive regulation of butyryl-CoA catabolic process to butanol label “obsolete positive regulation of butyryl-CoA catabolic process to butanol”

positive regulation of butyryl-CoA catabolic process to butyrate term tracker item “https://github.com/geneontology/go-ontology/issues/31933”^^anyURI
positive regulation of butyryl-CoA catabolic process to butyrate definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of butyryl-CoA catabolic process to butyrate.”
- has cross-reference “GOC:mengo_curators”
- has cross-reference “GOC:TermGenie”
positive regulation of butyryl-CoA catabolic process to butyrate deprecated true
positive regulation of butyryl-CoA catabolic process to butyrate comment “This term was obsoleted because it is an unnecessary grouping term.”
positive regulation of butyryl-CoA catabolic process to butyrate label “obsolete positive regulation of butyryl-CoA catabolic process to butyrate”

positive regulation of fatty acid beta-oxidation by octopamine signaling pathway term tracker item “https://github.com/geneontology/go-ontology/issues/32064”^^anyURI
positive regulation of fatty acid beta-oxidation by octopamine signaling pathway definition “OBSOLETE. An octopamine signaling pathway that results in positive regulation of fatty acid beta-oxidation.”
- has cross-reference “PMID:24120942”
- has cross-reference “GOC:dph”
- has cross-reference “GOC:kmv”
- has cross-reference “GO_REF:0000063”
- has cross-reference “GOC:TermGenie”
positive regulation of fatty acid beta-oxidation by octopamine signaling pathway deprecated true
positive regulation of fatty acid beta-oxidation by octopamine signaling pathway comment “The reason for obsoletion is that this term represents a GO-CAM model (an upstream signaling event that positively regulates fatty acid beta-oxidation), which is better captured as a causal model in GO-CAM rather than as a standard GO term.”
positive regulation of fatty acid beta-oxidation by octopamine signaling pathway label “obsolete positive regulation of fatty acid beta-oxidation by octopamine signaling pathway”

positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway term tracker item “https://github.com/geneontology/go-ontology/issues/32064”^^anyURI
positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway definition “OBSOLETE. A serotonin receptor signaling pathway that results in positive regulation of fatty acid beta-oxidation.”
- has cross-reference “PMID:24120942”
- has cross-reference “GOC:dph”
- has cross-reference “GOC:kmv”
- has cross-reference “GO_REF:0000063”
- has cross-reference “GOC:TermGenie”
positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway deprecated true
positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway comment “The reason for obsoletion is that this term represents a GO-CAM model (an upstream signaling event that positively regulates fatty acid beta-oxidation), which is better captured as a causal model in GO-CAM rather than as a standard GO term.”
positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway label “obsolete positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway”

positive regulation of nitric oxide mediated signal transduction term tracker item “https://github.com/geneontology/go-ontology/issues/26613”^^anyURI
positive regulation of nitric oxide mediated signal transduction term replaced by positive regulation of nitric oxide-cGMP mediated signal transduction
positive regulation of nitric oxide mediated signal transduction definition “OBSOLETE. Any process that increases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO).”
- has cross-reference “GOC:dph”
- has cross-reference “GOC:tb”
- has cross-reference “GOC:BHF”
positive regulation of nitric oxide mediated signal transduction deprecated true
positive regulation of nitric oxide mediated signal transduction comment “The reason for obsoletion is that this term has been inconsistently used and NO signaling proceeds via cGMP, so the more specific replacement term is preferred.”
positive regulation of nitric oxide mediated signal transduction label “obsolete positive regulation of nitric oxide mediated signal transduction”

propionate CoA-transferase activity definition “Catalysis of the reaction: acetyl-CoA + propanoate = acetate + propanoyl-CoA.”
- has cross-reference “EC:2.8.3.1”

propionate CoA-transferase activity definition “Catalysis of the reaction: acetyl-CoA + propanoate = acetate + propanoyl-CoA.”
- has cross-reference “RHEA:23520”

propionyl-CoA:succinate CoA-transferase activity definition “Catalysis of the reaction: succinate + propionyl-CoA = succinyl-CoA + propionate.”
- has cross-reference “PMID:10769117”

propionyl-CoA:succinate CoA-transferase activity definition “Catalysis of the reaction: succinate + propionyl-CoA = succinyl-CoA + propionate.”
- has cross-reference “RHEA:28010”
- has cross-reference “PMID:10769117”

protein O-linked glycosylation via N-acetyl-galactosamine label “protein O-linked glycosylation via N-acetyl-galactosamine”

protein carrier activity definition “Binding to and carrying a protein to an acceptor molecule or to a specific location by moving along with the target protein.”
- has cross-reference “PMID:7628437”

protein carrier activity definition “Directly binding to a protein and delivering it either to an acceptor molecule or to a specific location.”
- has cross-reference “PMID:7628437”

protein import into mitochondrial matrix term tracker item “/github.com/geneontology/go-ontology/issues/29962”^^anyURI
protein import into mitochondrial matrix definition “The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.”
- has cross-reference “ISBN:0716731363”
protein import into mitochondrial matrix SubClassOf intercellular transport
protein import into mitochondrial matrix SubClassOf protein transmembrane transport
protein import into mitochondrial matrix SubClassOf establishment of protein localization to organelle
protein import into mitochondrial matrix SubClassOf has target start location some cytosol
protein import into mitochondrial matrix SubClassOf has target end location some mitochondrial matrix
protein import into mitochondrial matrix SubClassOf results in transport across some mitochondrial membrane

protein-containing complex definition “A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.”

protein-macromolecule adaptor activity term tracker item “https://github.com/geneontology/go-ontology/issues/31444”^^anyURI
protein-macromolecule adaptor activity comment “Note that protein complex scaffolds should use GO:0140378 protein complex scaffold activity.”

protoporphyrinogen IX biosynthetic process from glutamate term tracker item “https://github.com/geneontology/go-ontology/issues/31788”^^anyURI
protoporphyrinogen IX biosynthetic process from glutamate definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glutamate.”
- has cross-reference “PMID:32976912”
protoporphyrinogen IX biosynthetic process from glutamate deprecated true
protoporphyrinogen IX biosynthetic process from glutamate comment “This term was obsoleted because protoporphyrinogen IX is an intermediate in heme/chlorophyll/uroporphyrinogen biosynthesis.”
protoporphyrinogen IX biosynthetic process from glutamate label “obsolete protoporphyrinogen IX biosynthetic process from glutamate”

protoporphyrinogen IX metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31788”^^anyURI
protoporphyrinogen IX metabolic process definition “OBSOLETE. The chemical reactions and pathways involving protoporphyrinogen IX, the specific substrate for the enzyme ferrochelatase, which catalyzes the insertion of iron to form protoheme. It is probably also the substrate for chlorophyll formation.”
- has cross-reference “ISBN:0198506732”
protoporphyrinogen IX metabolic process deprecated true
protoporphyrinogen IX metabolic process comment “This term was obsoleted because protoporphyrinogen IX is an intermediate in heme/chlorophyll/uroporphyrinogen biosynthesis.”
protoporphyrinogen IX metabolic process label “obsolete protoporphyrinogen IX metabolic process”

protoporphyrinogen oxidase activity definition “Catalysis of the reaction: protoporphyrinogen IX + acceptor = protoporphyrin IX + reduced acceptor.”
- has cross-reference “GOC:mah”
- has cross-reference “PMID:19583219”

putrescine biosynthetic process from arginine via N-carbamoylputrescine term tracker item “https://github.com/geneontology/go-ontology/issues/31766”^^anyURI
putrescine biosynthetic process from arginine via N-carbamoylputrescine term replaced by putrescine biosynthetic process
putrescine biosynthetic process from arginine via N-carbamoylputrescine definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine, via the intermediate N-carbamoylputrescine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in two single enzymatic steps.”
- has cross-reference “GOC:mah”
- has cross-reference “MetaCyc:PWY-43”
putrescine biosynthetic process from arginine via N-carbamoylputrescine deprecated true
putrescine biosynthetic process from arginine via N-carbamoylputrescine comment “The reason for obsoletion is that this term represents a GO-CAM.”
putrescine biosynthetic process from arginine via N-carbamoylputrescine label “obsolete putrescine biosynthetic process from arginine via N-carbamoylputrescine”

pyruvate family amino acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of any amino acid that requires pyruvate for its synthesis, e.g. alanine.”
- has cross-reference “GOC:jl”

pyruvate family amino acid biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/32000”^^anyURI
pyruvate family amino acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of an L-amino acid derived from pyruvate (L-alanine, L-valine, and L-leucine).”
- has cross-reference “GOC:curators”

regulation of COPII vesicle coating term tracker item “https://github.com/geneontology/go-ontology/issues/31945”^^anyURI
regulation of COPII vesicle coating term replaced by COPII vesicle coating
regulation of COPII vesicle coating definition “OBSOLETE. Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat.”
- has cross-reference “GOC:dph”
- has cross-reference “GOC:jp”
- has cross-reference “GOC:tb”
- has cross-reference “GOC:ascb_2009”
regulation of COPII vesicle coating deprecated true
regulation of COPII vesicle coating comment “This term was obsoleted because the proteins previously annotated to it are part_of the COPII vesicle coating pathway rather than upstream regulators of it. Annotations should be moved to GO:0048208 COPII vesicle coat assembly.”
regulation of COPII vesicle coating label “obsolete regulation of COPII vesicle coating”

regulation of L-dopa biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31703”^^anyURI
regulation of L-dopa biosynthetic process definition “OBSOLETE. Any process that modulates the frequency, rate or extent of L-dopa biosynthetic process.”
- has cross-reference “GO_REF:0000058”
- has cross-reference “GOC:PARL”
- has cross-reference “GOC:bf”
- has cross-reference “GOC:TermGenie”
regulation of L-dopa biosynthetic process deprecated true
regulation of L-dopa biosynthetic process comment “This term was obsoleted because there is no evidence that this process exists.”
regulation of L-dopa biosynthetic process label “obsolete regulation of L-dopa biosynthetic process”

regulation of butyryl-CoA biosynthetic process from acetyl-CoA term tracker item “https://github.com/geneontology/go-ontology/issues/31933”^^anyURI
regulation of butyryl-CoA biosynthetic process from acetyl-CoA definition “OBSOLETE. Any process that modulates the frequency, rate or extent of butyryl-CoA biosynthetic process from acetyl-CoA.”
- has cross-reference “GOC:mengo_curators”
- has cross-reference “GOC:TermGenie”
regulation of butyryl-CoA biosynthetic process from acetyl-CoA deprecated true
regulation of butyryl-CoA biosynthetic process from acetyl-CoA comment “This term was obsoleted because it is an unnecessary grouping term.”
regulation of butyryl-CoA biosynthetic process from acetyl-CoA label “obsolete regulation of butyryl-CoA biosynthetic process from acetyl-CoA”

regulation of butyryl-CoA catabolic process to butanol term tracker item “https://github.com/geneontology/go-ontology/issues/31933”^^anyURI
regulation of butyryl-CoA catabolic process to butanol definition “OBSOLETE. Any process that modulates the frequency, rate or extent of butyryl-CoA catabolic process to butanol.”
- has cross-reference “GOC:mengo_curators”
- has cross-reference “GOC:TermGenie”
regulation of butyryl-CoA catabolic process to butanol deprecated true
regulation of butyryl-CoA catabolic process to butanol comment “This term was obsoleted because it is an unnecessary grouping term.”
regulation of butyryl-CoA catabolic process to butanol label “obsolete regulation of butyryl-CoA catabolic process to butanol”

regulation of butyryl-CoA catabolic process to butyrate term tracker item “https://github.com/geneontology/go-ontology/issues/31933”^^anyURI
regulation of butyryl-CoA catabolic process to butyrate definition “OBSOLETE. Any process that modulates the frequency, rate or extent of butyryl-CoA catabolic process to butyrate.”
- has cross-reference “GOC:mengo_curators”
- has cross-reference “GOC:TermGenie”
regulation of butyryl-CoA catabolic process to butyrate deprecated true
regulation of butyryl-CoA catabolic process to butyrate comment “This term was obsoleted because it is an unnecessary grouping term.”
regulation of butyryl-CoA catabolic process to butyrate label “obsolete regulation of butyryl-CoA catabolic process to butyrate”

regulation of methane biosynthetic process from carbon monoxide term tracker item “https://github.com/geneontology/go-ontology/issues/31933”^^anyURI
regulation of methane biosynthetic process from carbon monoxide definition “OBSOLETE. Any process that modulates the frequency, rate or extent of methane biosynthetic process from carbon monoxide.”
- has cross-reference “GOC:mengo_curators”
- has cross-reference “GOC:TermGenie”
regulation of methane biosynthetic process from carbon monoxide deprecated true
regulation of methane biosynthetic process from carbon monoxide comment “This term was obsoleted because it is an unnecessary grouping term.”
regulation of methane biosynthetic process from carbon monoxide label “obsolete regulation of methane biosynthetic process from carbon monoxide”

regulation of methane biosynthetic process from dimethyl sulfide term tracker item “https://github.com/geneontology/go-ontology/issues/31933”^^anyURI
regulation of methane biosynthetic process from dimethyl sulfide definition “OBSOLETE. Any process that modulates the frequency, rate or extent of methane biosynthetic process from dimethyl sulfide.”
- has cross-reference “GOC:mengo_curators”
- has cross-reference “GOC:TermGenie”
regulation of methane biosynthetic process from dimethyl sulfide deprecated true
regulation of methane biosynthetic process from dimethyl sulfide comment “This term was obsoleted because it is an unnecessary grouping term.”
regulation of methane biosynthetic process from dimethyl sulfide label “obsolete regulation of methane biosynthetic process from dimethyl sulfide”

regulation of methane biosynthetic process from dimethylamine term tracker item “https://github.com/geneontology/go-ontology/issues/31933”^^anyURI
regulation of methane biosynthetic process from dimethylamine definition “OBSOLETE. Any process that modulates the frequency, rate or extent of methane biosynthetic process from dimethylamine.”
- has cross-reference “GOC:mengo_curators”
- has cross-reference “GOC:TermGenie”
regulation of methane biosynthetic process from dimethylamine deprecated true
regulation of methane biosynthetic process from dimethylamine comment “This term was obsoleted because it is an unnecessary grouping term.”
regulation of methane biosynthetic process from dimethylamine label “obsolete regulation of methane biosynthetic process from dimethylamine”

regulation of methane biosynthetic process from formic acid term tracker item “https://github.com/geneontology/go-ontology/issues/31933”^^anyURI
regulation of methane biosynthetic process from formic acid definition “OBSOLETE. Any process that modulates the frequency, rate or extent of methane biosynthetic process from formic acid.”
- has cross-reference “GOC:mengo_curators”
- has cross-reference “GOC:TermGenie”
regulation of methane biosynthetic process from formic acid deprecated true
regulation of methane biosynthetic process from formic acid comment “This term was obsoleted because it is an unnecessary grouping term.”
regulation of methane biosynthetic process from formic acid label “obsolete regulation of methane biosynthetic process from formic acid”

regulation of methane biosynthetic process from methanethiol term tracker item “https://github.com/geneontology/go-ontology/issues/31933”^^anyURI
regulation of methane biosynthetic process from methanethiol definition “OBSOLETE. Any process that modulates the frequency, rate or extent of methane biosynthetic process from methanethiol.”
- has cross-reference “GOC:mengo_curators”
- has cross-reference “GOC:TermGenie”
regulation of methane biosynthetic process from methanethiol deprecated true
regulation of methane biosynthetic process from methanethiol comment “This term was obsoleted because it is an unnecessary grouping term.”
regulation of methane biosynthetic process from methanethiol label “obsolete regulation of methane biosynthetic process from methanethiol”

regulation of methane biosynthetic process from methylamine term tracker item “https://github.com/geneontology/go-ontology/issues/31933”^^anyURI
regulation of methane biosynthetic process from methylamine definition “OBSOLETE. Any process that modulates the frequency, rate or extent of methane biosynthetic process from methylamine.”
- has cross-reference “GOC:mengo_curators”
- has cross-reference “GOC:TermGenie”
regulation of methane biosynthetic process from methylamine deprecated true
regulation of methane biosynthetic process from methylamine comment “This term was obsoleted because it is an unnecessary grouping term.”
regulation of methane biosynthetic process from methylamine label “obsolete regulation of methane biosynthetic process from methylamine”

regulation of methane biosynthetic process from trimethylamine term tracker item “https://github.com/geneontology/go-ontology/issues/31933”^^anyURI
regulation of methane biosynthetic process from trimethylamine definition “OBSOLETE. Any process that modulates the frequency, rate or extent of methane biosynthetic process from trimethylamine.”
- has cross-reference “GOC:mengo_curators”
- has cross-reference “GOC:TermGenie”
regulation of methane biosynthetic process from trimethylamine deprecated true
regulation of methane biosynthetic process from trimethylamine comment “This term was obsoleted because it is an unnecessary grouping term.”
regulation of methane biosynthetic process from trimethylamine label “obsolete regulation of methane biosynthetic process from trimethylamine”

regulation of nitric oxide mediated signal transduction term tracker item “https://github.com/geneontology/go-ontology/issues/26613”^^anyURI
regulation of nitric oxide mediated signal transduction term replaced by regulation of nitric oxide-cGMP mediated signal transduction
regulation of nitric oxide mediated signal transduction definition “OBSOLETE. Any process that modulates the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO).”
- has cross-reference “GOC:dph”
- has cross-reference “GOC:tb”
- has cross-reference “GOC:BHF”
regulation of nitric oxide mediated signal transduction deprecated true
regulation of nitric oxide mediated signal transduction comment “The reason for obsoletion is that this term has been inconsistently used and NO signaling proceeds via cGMP, so the more specific replacement term is preferred.”
regulation of nitric oxide mediated signal transduction label “obsolete regulation of nitric oxide mediated signal transduction”

regulation of tetrapyrrole biosynthetic process from glutamate term tracker item “https://github.com/geneontology/go-ontology/issues/31933”^^anyURI
regulation of tetrapyrrole biosynthetic process from glutamate definition “OBSOLETE. Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process from glutamate.”
- has cross-reference “GOC:mengo_curators”
- has cross-reference “GOC:TermGenie”
regulation of tetrapyrrole biosynthetic process from glutamate deprecated true
regulation of tetrapyrrole biosynthetic process from glutamate comment “This term was obsoleted because it is an unnecessary grouping term.”
regulation of tetrapyrrole biosynthetic process from glutamate label “obsolete regulation of tetrapyrrole biosynthetic process from glutamate”

AnnotationProperty: relatedMatch

retrograde transporter complex, Golgi to ER has exact synonym “retrograde transporter complex, Golgi to endoplasmic reticulum”
retrograde transporter complex, Golgi to ER definition “Transporter complex that recognises, binds and returns endoplasmic reticulum (ER) resident proteins that have trafficked to Golgi compartments. Targets proteins lacking the HDEL motif recognised by COPI-coated vesicles.”
- has cross-reference “PMID:16093310”
- has cross-reference “GOC:bhm”
retrograde transporter complex, Golgi to ER label “retrograde transporter complex, Golgi to ER”
retrograde transporter complex, Golgi to ER SubClassOf transporter complex

retrograde transporter complex, Golgi to ER term tracker item “https://github.com/geneontology/go-ontology/issues/31935”^^anyURI
retrograde transporter complex, Golgi to ER has_broad_synonym “retrograde transporter complex, Golgi to ER”
retrograde transporter complex, Golgi to ER has exact synonym “retrograde cargo receptor complex, Golgi to endoplasmic reticulum”
retrograde transporter complex, Golgi to ER definition “Cargo receptor complex that recognizes, binds and returns endoplasmic reticulum (ER) resident proteins that have trafficked to Golgi compartments. Targets proteins lacking the HDEL motif recognised by COPI-coated vesicles.”
- has cross-reference “PMID:16093310”
- has cross-reference “GOC:bhm”
retrograde transporter complex, Golgi to ER label “retrograde cargo receptor complex, Golgi to ER”
retrograde transporter complex, Golgi to ER SubClassOf cargo receptor complex

ricinine nitrilase activity definition “Catalysis of the reaction: ricinine + 2 H2O = 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4+.”
- has cross-reference “RHEA:22704”

ricinine nitrilase activity definition “Catalysis of the reaction: ricinine + 2 H2O = 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4+.”
- has cross-reference “RHEA:22704”

scopoletin 8-hydroxylase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31969”^^anyURI
scopoletin 8-hydroxylase activity definition “Catalysis of the reaction: scopoletin + 2-oxoglutarate + O2 = fraxetin + succinate + CO2.”
- has cross-reference “RHEA:57848”
- has cross-reference “PMID:29361149”
- has cross-reference “PMID:29581584”
scopoletin 8-hydroxylase activity SubClassOf 2-oxoglutarate-dependent dioxygenase activity

serine family amino acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.”
- has cross-reference “GOC:ai”
serine family amino acid biosynthetic process SubClassOf alpha-amino acid biosynthetic process

serotonin biosynthetic process from L-tryptophan term replaced by serotonin biosynthetic process
serotonin biosynthetic process from L-tryptophan definition “OBSOLETE. The chemical reactions and pathways resulting in the formation from L-tryptophan of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.”
- has cross-reference “PMID:30901029”
- has cross-reference “PMID:35495641”
- has cross-reference “ISBN:0198506732”
- has cross-reference “GOC:jl”
serotonin biosynthetic process from L-tryptophan deprecated true
serotonin biosynthetic process from L-tryptophan comment “The reason for obsoletion is that the term is too specific.”
serotonin biosynthetic process from L-tryptophan label “obsolete serotonin biosynthetic process from L-tryptophan”

serotonin transport conformsTo chemical_transport.yaml
serotonin transport definition “The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems.”
- has cross-reference “GOC:ai”
serotonin transport label “serotonin transport”
serotonin transport EquivalentTo transport and (has primary input some serotonin(1+))
serotonin transport SubClassOf monoamine transport
serotonin transport SubClassOf organic hydroxy compound transport
serotonin transport SubClassOf has primary input some serotonin(1+)

serotonin transport term tracker item “https://github.com/geneontology/go-ontology/issues/31143”^^anyURI
serotonin transport definition “OBSOLETE. The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems.”
- has cross-reference “GOC:ai”
serotonin transport deprecated true
serotonin transport comment “The reason for obsoletion is that this is an unnecessary grouping term and annotations should be made to more mechanism/location specific terms.”
serotonin transport label “obsolete serotonin transport”

signal sequence binding definition “Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized.”
- has cross-reference “GOC:ai”
signal sequence binding label “signal sequence binding”
signal sequence binding SubClassOf peptide binding

signal sequence binding term tracker item “https://github.com/geneontology/go-ontology/issues/31419”^^anyURI
signal sequence binding has narrow synonym “signal sequence binding”
signal sequence binding definition “Binding to a signal sequence, a short stretch of amino acids found in a protein that acts as a signal for its proper localization in the cell.”
- has cross-reference “GOC:curators”
signal sequence binding label “signal sequence receptor activity”
signal sequence binding SubClassOf molecular_function

spermine acetylation term tracker item “https://github.com/geneontology/go-ontology/issues/31741”^^anyURI
spermine acetylation consider diamine N-acetyltransferase activity
spermine acetylation consider spermine catabolic process
spermine acetylation definition “OBSOLETE. The modification of spermine by addition of acetyl groups.”
- has cross-reference “GOC:mlg”
spermine acetylation deprecated true
spermine acetylation comment “The reason for obsoletion is that this term represents a molecular function.”
spermine acetylation label “obsolete spermine acetylation”

succinate-hydroxymethylglutarate CoA-transferase activity definition “Catalysis of the reaction: (S)-3-hydroxy-3-methylglutarate + succinyl-CoA = 3-hydroxy-3-methyl-glutaryl-CoA + succinate.”
- has cross-reference “EC:2.8.3.13”
- has cross-reference “MetaCyc:2.8.3.13-RXN”

succinate-hydroxymethylglutarate CoA-transferase activity definition “Catalysis of the reaction: 3-hydroxy-3-methylglutarate + succinyl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + succinate.”
- has cross-reference “RHEA:12284”

succinyl-CoA:(R)-benzylsuccinate CoA-transferase activity definition “Catalysis of the reaction: (R)-2-benzylsuccinate + succinyl-CoA = (R)-2-benzylsuccinyl-CoA + succinate.”
- has cross-reference “EC:2.8.3.15”
- has cross-reference “RHEA:16469”

succinyl-CoA:(R)-benzylsuccinate CoA-transferase activity definition “Catalysis of the reaction: (R)-2-benzylsuccinate + succinyl-CoA = (R)-2-benzylsuccinyl-CoA + succinate.”
- has cross-reference “RHEA:16469”

succinyl-CoA:(R)-citramalate CoA-transferase activity definition “Catalysis of the reaction: succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA.”
- has cross-reference “PMID:17259315”
- has cross-reference “GOC:jl”

succinyl-CoA:(R)-citramalate CoA-transferase activity definition “Catalysis of the reaction: succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA.”
- has cross-reference “RHEA:38279”
- has cross-reference “PMID:17259315”

sugar-phosphatase activity definition “Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate.”
- has cross-reference “EC:3.1.3.23”
- has cross-reference “MetaCyc:SUGAR-PHOSPHATASE-RXN”

sugar-phosphatase activity definition “Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate.”
- has cross-reference “EC:3.1.3.23”

sulfate adenylyltransferase (ATP) activity definition “Catalysis of the reaction: ATP + H+ + sulfate = adenosine 5’-phosphosulfate + diphosphate.”
- has cross-reference “EC:2.7.7.4”

sulfate adenylyltransferase (ATP) activity definition “Catalysis of the reaction: sulfate + ATP + H+ = adenosine 5’-phosphosulfate + diphosphate.”
- has cross-reference “RHEA:18133”

sulfide oxidation has cross-reference “MetaCyc:Sulfide-Oxidation”
sulfide oxidation definition “The chemical reactions and pathways resulting in the conversion of sulfide to elemental sulfur in a higher oxidation state, or to sulfite or sulfate.”
- has cross-reference “MetaCyc:Sulfide-Oxidation”

synaptic vesicle targeting term tracker item “https://github.com/geneontology/go-ontology/issues/31864”^^anyURI
synaptic vesicle targeting term replaced by synaptic vesicle exocytosis
synaptic vesicle targeting definition “OBSOLETE. The process in which synaptic vesicles are directed to specific destination membranes, mediated by molecules at the vesicle membrane and target membrane surfaces.”
- has cross-reference “GOC:mah”
synaptic vesicle targeting deprecated true
synaptic vesicle targeting comment “This term was made obsolete because the meaning of the term is ambiguous and usage has been inconsistent. The process it intended to describe is encompassed by the parent term synaptic vesicle exocytosis.”
synaptic vesicle targeting label “obsolete synaptic vesicle targeting”

synaptic vesicle tethering involved in synaptic vesicle exocytosis term tracker item “https://github.com/geneontology/go-ontology/issues/31871”^^anyURI
synaptic vesicle tethering involved in synaptic vesicle exocytosis consider synaptic vesicle exocytosis
synaptic vesicle tethering involved in synaptic vesicle exocytosis consider vesicle membrane tethering activity
synaptic vesicle tethering involved in synaptic vesicle exocytosis definition “OBSOLETE. The initial, indirect interaction between a synaptic vesicle membrane and a the preseynaptic membrane active zone. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. This process is distinct from and prior to synaptic vesicle priming and fusion.”
- has cross-reference “GOC:rn”
synaptic vesicle tethering involved in synaptic vesicle exocytosis deprecated true
synaptic vesicle tethering involved in synaptic vesicle exocytosis comment “This term was obsoleted because it represents a molecular function (vesicle membrane tethering activity) rather than a biological process, and is pre-composed; the same information is better represented as a GO-CAM model. Annotations should be reviewed and reannotated to the new MF term GO:7770062 ‘vesicle membrane tethering activity’, combined with GO:0016079 ‘synaptic vesicle exocytosis’ as appropriate.”
synaptic vesicle tethering involved in synaptic vesicle exocytosis label “obsolete synaptic vesicle tethering involved in synaptic vesicle exocytosis”

tRNA wobble position uridine thiolation definition “The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.”
- has cross-reference “PMID:16871210”

tRNA wobble position uridine thiolation definition “The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from L-cysteine to position C2 by several steps.”
- has cross-reference “PMID:16871210”

terephthalate 1,2-dioxygenase activity definition “Catalysis of the reaction: H+ + NADH + O2 + terephthalate = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD+.”
- has cross-reference “RHEA:10312”
- has cross-reference “EC:1.14.12.15”

terephthalate 1,2-dioxygenase activity definition “Catalysis of the reaction: terephthalate + NADH + O2 + H+ = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD+.”
- has cross-reference “RHEA:10312”

toluene dioxygenase activity definition “Catalysis of the reaction: H+ + NADH + O2 + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+.”
- has cross-reference “RHEA:16737”
- has cross-reference “EC:1.14.12.11”

toluene dioxygenase activity definition “Catalysis of the reaction: toluene + NADH + O2 + H+ = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+.”
- has cross-reference “RHEA:16737”

trimethylenediamine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31766”^^anyURI
trimethylenediamine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of trimethylenediamine.”
- has cross-reference “UniPathway:UPA00010”
- has cross-reference “GOC:yaf”
- has cross-reference “GOC:TermGenie”
trimethylenediamine catabolic process deprecated true
trimethylenediamine catabolic process comment “The reason for obsoletion is that this term was made in error.”
trimethylenediamine catabolic process label “obsolete trimethylenediamine catabolic process”

tubulin folding cofactor complex definition “A multimeric protein complex involved in tubulin alpha-beta-subunit folding assembly consisting of beta-tubulin-TFC-D, alpha-tubulin-TFC-E and TFC-C, through which tubulin subunit association and dimer release occur.”
- has cross-reference “PMID:12445400”
- has cross-reference “GOC:vw”
tubulin folding cofactor complex label “tubulin folding cofactor complex”
tubulin folding cofactor complex SubClassOf protein-containing complex
tubulin folding cofactor complex SubClassOf capable of part of some tubulin complex assembly

tubulin folding cofactor complex term tracker item “https://github.com/geneontology/go-ontology/issues/31828”^^anyURI
tubulin folding cofactor complex definition “OBSOLETE. A multimeric protein complex involved in tubulin alpha-beta-subunit folding assembly consisting of beta-tubulin-TFC-D, alpha-tubulin-TFC-E and TFC-C, through which tubulin subunit association and dimer release occur.”
- has cross-reference “PMID:12445400”
- has cross-reference “GOC:vw”
tubulin folding cofactor complex deprecated true
tubulin folding cofactor complex comment “This term was obsoleted because it was created by mistake; this is a pathway, not a complex.”
tubulin folding cofactor complex label “obsolete tubulin folding cofactor complex”

tyramine transport conformsTo chemical_transport.yaml
tyramine transport created by “dragon-ai-agent”
tyramine transport definition “The directed movement of tyramine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Tyramine is a monoamine neurotransmitter occurring predominantly in invertebrates.”
- has cross-reference “PMID:15849736”
- has cross-reference “PMID:32305263”
- has cross-reference “PMID:9870940”
tyramine transport label “tyramine transport”
tyramine transport EquivalentTo transport and (has primary input some tyraminium)
tyramine transport SubClassOf monoamine transport
tyramine transport SubClassOf organic hydroxy compound transport
tyramine transport SubClassOf has primary input some tyraminium

tyramine transport definition “OBSOLETE. The directed movement of tyramine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Tyramine is a monoamine neurotransmitter occurring predominantly in invertebrates.”
- has cross-reference “PMID:15849736”
- has cross-reference “PMID:32305263”
- has cross-reference “PMID:9870940”
tyramine transport deprecated true
tyramine transport comment “The reason for obsoletion is that this is an unnecessary grouping term and annotations should be made to more mechanism/location specific terms.”
tyramine transport label “obsolete tyramine transport”

tyrosine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI
tyrosine metabolic process consider L-tyrosine biosynthetic process
tyrosine metabolic process consider L-tyrosine catabolic process
tyrosine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.”
- has cross-reference “GOC:curators”
tyrosine metabolic process deprecated true
tyrosine metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
tyrosine metabolic process label “obsolete tyrosine metabolic process”

unfolded protein binding term tracker item “https://github.com/geneontology/go-ontology/issues/30962”^^anyURI
unfolded protein binding consider protein folding chaperone
unfolded protein binding consider unfolded protein holdase activity
unfolded protein binding definition “OBSOLETE. Binding to an unfolded protein.”
- has cross-reference “GOC:ai”
unfolded protein binding deprecated true
unfolded protein binding comment “The reason for obsoletion is that this binding term should be replaced by an activity term such as protein folding chaperone (GO:0044183) or unfolded protein holdase activity (GO:0140309).”
unfolded protein binding label “obsolete unfolded protein binding”

vacuole-ER tethering term tracker item “https://github.com/geneontology/go-ontology/issues/31874”^^anyURI
vacuole-ER tethering consider endoplasmic reticulum-vacuole tether activity
vacuole-ER tethering definition “OBSOLETE. The attachment of a lytic vacuole to the endoplasmic reticulum, which may facilitate exchange of metabolites between the organelles.”
- has cross-reference “PMID:26283797”
vacuole-ER tethering deprecated true
vacuole-ER tethering comment “The reason for obsoletion is that this term represents a molecular function, not a biological process. The molecular function is captured by GO:7770066 endoplasmic reticulum-vacuole tether activity.”
vacuole-ER tethering label “obsolete vacuole-ER tethering”

vacuole-mitochondria membrane tethering definition “The attachment of a mitochondrial membrane to a vacuolar membrane via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles.”
- has cross-reference “PMID:27875684”
vacuole-mitochondria membrane tethering label “vacuole-mitochondria membrane tethering”
vacuole-mitochondria membrane tethering SubClassOf organelle localization by membrane tethering
vacuole-mitochondria membrane tethering SubClassOf in taxon some Eukaryota

vacuole-mitochondria membrane tethering term tracker item “https://github.com/geneontology/go-ontology/issues/31876”^^anyURI
vacuole-mitochondria membrane tethering definition “OBSOLETE. The attachment of a mitochondrial membrane to a vacuolar membrane via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles.”
- has cross-reference “PMID:27875684”
vacuole-mitochondria membrane tethering deprecated true
vacuole-mitochondria membrane tethering comment “The reason for obsoletion is that this term was added in error.”
vacuole-mitochondria membrane tethering label “obsolete vacuole-mitochondria membrane tethering”

valine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI
valine metabolic process consider L-valine catabolic process
valine metabolic process consider L-valine biosynthetic process
valine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid.”
- has cross-reference “GOC:ai”
valine metabolic process deprecated true
valine metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
valine metabolic process label “obsolete valine metabolic process”

vesicle coating has_broad_synonym “vesicle coat assembly”
vesicle coating label “vesicle coating”

vesicle coating has exact synonym “vesicle coating”
vesicle coating label “vesicle coat assembly”

Class: vesicle docking activity
vesicle docking activity term tracker item “https://github.com/geneontology/go-ontology/issues/31880”^^anyURI
vesicle docking activity created by “rynl”
vesicle docking activity creation date “2026-04-17T21:35:33Z”
vesicle docking activity has_obo_namespace “molecular_function”
vesicle docking activity id “GO:0160321”
vesicle docking activity definition “The binding activity of a protein that directly mediates the stable attachment of a transport vesicle to a target membrane, bringing the two membranes into close apposition.”
- has cross-reference “PMID:28237810”
vesicle docking activity comment “Vesicle docking activity succeeds vesicle tethering activity and precedes fusogenic activity in the vesicle membrane fusion pathway.”
vesicle docking activity label “vesicle docking activity”
vesicle docking activity SubClassOf membrane-membrane adaptor activity

vesicle targeting, trans-Golgi to periciliary membrane compartment definition “The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces.”
- has cross-reference “PMID:23351793”
- has cross-reference “PMID:20106869”
- has cross-reference “PMID:26485645”
- has cross-reference “PMID:24814148”
- has cross-reference “GOC:cilia”
vesicle targeting, trans-Golgi to periciliary membrane compartment label “vesicle targeting, trans-Golgi to periciliary membrane compartment”
vesicle targeting, trans-Golgi to periciliary membrane compartment SubClassOf vesicle targeting, to, from or within Golgi

vesicle targeting, trans-Golgi to periciliary membrane compartment term tracker item “https://github.com/geneontology/go-ontology/issues/31865”^^anyURI
vesicle targeting, trans-Golgi to periciliary membrane compartment has_related_synonym “vesicle targeting, trans-Golgi to periciliary membrane compartment”
vesicle targeting, trans-Golgi to periciliary membrane compartment definition “The directed movement of substances from the trans-Golgi network to the periciliary membrane compartment, the specialized region of the plasma membrane surrounding the base of the cilium including the ciliary pocket, via vesicle-mediated transport.”
- has cross-reference “PMID:23351793”
- has cross-reference “PMID:20106869”
- has cross-reference “PMID:26485645”
- has cross-reference “PMID:24814148”
vesicle targeting, trans-Golgi to periciliary membrane compartment label “trans-Golgi to periciliary membrane compartment transport”
vesicle targeting, trans-Golgi to periciliary membrane compartment SubClassOf Golgi to plasma membrane transport

vesicle tethering definition “The initial, indirect interaction between a vesicle membrane and a membrane to which it is targeted for fusion. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to interaction between factors involved in fusion.”
- has cross-reference “PMID:27243008”
vesicle tethering label “vesicle tethering”
vesicle tethering SubClassOf cellular component organization
vesicle tethering SubClassOf part of some vesicle targeting
vesicle tethering SubClassOf in taxon some Eukaryota

vesicle tethering term tracker item “https://github.com/geneontology/go-ontology/issues/31881”^^anyURI
vesicle tethering consider vesicle membrane tethering activity
vesicle tethering definition “OBSOLETE. The initial, indirect interaction between a vesicle membrane and a membrane to which it is targeted for fusion. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to interaction between factors involved in fusion.”
- has cross-reference “PMID:27243008”
vesicle tethering deprecated true
vesicle tethering comment “This term was obsoleted because it represents a molecular function (vesicle membrane tethering activity) rather than a biological process. Annotations should be reviewed and reannotated to the new MF term GO:7770062 ‘vesicle membrane tethering activity’, and where appropriate combined with the relevant vesicle-mediated transport / exocytosis process term in a GO-CAM model.”
vesicle tethering label “obsolete vesicle tethering”

vesicle tethering involved in exocytosis conformsTo involved_in_x_y.yaml
vesicle tethering involved in exocytosis has narrow synonym “vesicle tethering to plasma membrane”
vesicle tethering involved in exocytosis definition “The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion.”
- has cross-reference “PMID:17488620”
- has cross-reference “PMID:17052174”
- has cross-reference “GOC:rn”
- has cross-reference “PMID:22420621”
- has cross-reference “PMID:10559876”
- has cross-reference “PMID:27243008”
vesicle tethering involved in exocytosis label “vesicle tethering involved in exocytosis”
vesicle tethering involved in exocytosis EquivalentTo vesicle tethering and (part of some exocytosis)
vesicle tethering involved in exocytosis SubClassOf vesicle tethering
vesicle tethering involved in exocytosis SubClassOf exocytic process
vesicle tethering involved in exocytosis SubClassOf in taxon some Eukaryota

vesicle tethering involved in exocytosis term tracker item “https://github.com/geneontology/go-ontology/issues/31872”^^anyURI
vesicle tethering involved in exocytosis consider exocytosis
vesicle tethering involved in exocytosis consider vesicle membrane tethering activity
vesicle tethering involved in exocytosis definition “OBSOLETE. The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion.”
- has cross-reference “PMID:17488620”
- has cross-reference “PMID:17052174”
- has cross-reference “GOC:rn”
- has cross-reference “PMID:22420621”
- has cross-reference “PMID:10559876”
- has cross-reference “PMID:27243008”
vesicle tethering involved in exocytosis deprecated true
vesicle tethering involved in exocytosis comment “This term was obsoleted because it represents a molecular function (vesicle membrane tethering activity) rather than a biological process, and is pre-composed; the same information is better represented as a GO-CAM model. Annotations should be reviewed and reannotated to the new MF term GO:7770062 ‘vesicle membrane tethering activity’, combined with GO:0006887 ‘exocytosis’ or a descendant as appropriate.”
vesicle tethering involved in exocytosis label “obsolete vesicle tethering involved in exocytosis”

vesicle tethering to Golgi definition “The initial, indirect interaction between a transport vesicle membrane and the membrane of the Golgi. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion.”
- has cross-reference “PMID:27243008”
vesicle tethering to Golgi label “vesicle tethering to Golgi”
vesicle tethering to Golgi EquivalentTo vesicle tethering and (immediately causally upstream of some vesicle fusion with Golgi apparatus)
vesicle tethering to Golgi SubClassOf vesicle tethering
vesicle tethering to Golgi SubClassOf in taxon some Eukaryota
vesicle tethering to Golgi SubClassOf immediately causally upstream of some vesicle fusion with Golgi apparatus

vesicle tethering to Golgi term tracker item “https://github.com/geneontology/go-ontology/issues/31872”^^anyURI
vesicle tethering to Golgi consider vesicle membrane tethering activity
vesicle tethering to Golgi definition “OBSOLETE. The initial, indirect interaction between a transport vesicle membrane and the membrane of the Golgi. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion.”
- has cross-reference “PMID:27243008”
vesicle tethering to Golgi deprecated true
vesicle tethering to Golgi comment “This term was obsoleted because it represents a molecular function rather than a biological process, and is pre-composed; the same information is better represented as a GO-CAM model. Annotations should be reviewed and reannotated to GO:7770062 ‘vesicle membrane tethering activity’, combined with the appropriate vesicle transport pathway BP term as part of a GO-CAM model.”
vesicle tethering to Golgi label “obsolete vesicle tethering to Golgi”

vesicle tethering to endoplasmic reticulum definition “The initial, indirect interaction between a transport vesicle membrane and the membrane of the endoplasmic reticulum. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion.”
- has cross-reference “PMID:27243008”
vesicle tethering to endoplasmic reticulum label “vesicle tethering to endoplasmic reticulum”
vesicle tethering to endoplasmic reticulum EquivalentTo vesicle tethering and (immediately causally upstream of some vesicle fusion with endoplasmic reticulum)
vesicle tethering to endoplasmic reticulum SubClassOf vesicle tethering
vesicle tethering to endoplasmic reticulum SubClassOf in taxon some Eukaryota
vesicle tethering to endoplasmic reticulum SubClassOf immediately causally upstream of some vesicle fusion with endoplasmic reticulum

vesicle tethering to endoplasmic reticulum term tracker item “https://github.com/geneontology/go-ontology/issues/31868”^^anyURI
vesicle tethering to endoplasmic reticulum consider vesicle membrane tethering activity
vesicle tethering to endoplasmic reticulum definition “OBSOLETE. The initial, indirect interaction between a transport vesicle membrane and the membrane of the endoplasmic reticulum. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion.”
- has cross-reference “PMID:27243008”
vesicle tethering to endoplasmic reticulum deprecated true
vesicle tethering to endoplasmic reticulum comment “This term was obsoleted because it represents a molecular function rather than a biological process. Annotations should be reviewed; the VAP-related proteins previously annotated here are lipid transfer/adaptor proteins rather than vesicle tethers, and other types of membrane adaptor terms may be more appropriate. Where the activity is genuinely vesicle tethering, reannotate to GO:7770062 ‘vesicle membrane tethering activity’.”
vesicle tethering to endoplasmic reticulum label “obsolete vesicle tethering to endoplasmic reticulum”

virion component definition “Any constituent part of a virion, a complete fully infectious extracellular virus particle.”

vitamin D3 25-hydroxylase activity label “vitamin D3 25-hydroxylase activity”

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go-ontology

Ontology comparison

Left

Right

Ontology imports

Ontology annotations

Removed

Added

‘de novo’ NAD+ biosynthetic process from L-tryptophan http://purl.obolibrary.org/obo/GO_0034354

Removed

Added

(+)-abscisic acid 8’-hydroxylase activity http://purl.obolibrary.org/obo/GO_0010295

Removed

Added

(2E)-enoyl-CoA hydratase activity http://purl.obolibrary.org/obo/GO_0080023

Added

(2S)-2-amino-5-[[amino(methylimino)methyl]amino]pentanoic acid http://purl.obolibrary.org/obo/CHEBI_124959

Removed

(2S)-2-ammonio-5-{[iminio(methylamino)methyl]amino}pentanoate http://purl.obolibrary.org/obo/CHEBI_114953

Removed

(3R)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity http://purl.obolibrary.org/obo/GO_0106386

Added

(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity http://purl.obolibrary.org/obo/GO_0003857

Added

(R)-2-hydroxyisocaproate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0043713

Removed

Added

(R)-sulfopropanediol 2-dehydrogenase activity http://purl.obolibrary.org/obo/GO_0102157

Removed

Added

1,2-dehydro-N-acetyldopamine biosynthetic process http://purl.obolibrary.org/obo/GO_0120577

Added

1,2-dehydro-N-beta-alanyldopamine biosynthetic process http://purl.obolibrary.org/obo/GO_0120576

Added

1,2-dihydroxynaphthalene dioxygenase activity http://purl.obolibrary.org/obo/GO_0018554

Removed

Added

1,8-cineole 2-exo-monooxygenase activity http://purl.obolibrary.org/obo/GO_0102320

Removed

Added

1,8-cineole synthase activity http://purl.obolibrary.org/obo/GO_0102313

Removed

Added

1-acylglycerol-3-phosphate O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0003841

Added

1-acylglycerophosphocholine O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0047184

Removed

Added

1-acylglycerophosphoethanolamine O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0106262

Removed

Added

1-acylglycerophosphoserine O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0106263

Removed

Added

1-alkenylglycerophosphoethanolamine O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0047166

Removed

Added

1-alkyl-2-acetylglycerol O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0047167

Removed

Added

1-alkylglycerophosphocholine O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0047191

Removed

Added

1-aminocyclopropane-1-carboxylate catabolic process http://purl.obolibrary.org/obo/GO_0042217

Removed

Added

11-oxo-beta-amyrin 30-oxidase activity http://purl.obolibrary.org/obo/GO_0102375

Removed

Added

2,4-dienoyl-CoA reductase (NADPH) activity http://purl.obolibrary.org/obo/GO_0008670

Added

2,5-dioxovalerate dehydrogenase (NAD+) activity http://purl.obolibrary.org/obo/GO_0044104

Removed

Added

2,5-dioxovalerate dehydrogenase (NADP+) activity http://purl.obolibrary.org/obo/GO_0047533

Removed

Added

2-(omega-methylthio)alkylmalate dehydratase activity http://purl.obolibrary.org/obo/GO_0120528

Added

2-acylglycerol O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0003846

‘de novo’ NAD+ biosynthetic process from L-tryptophan `http://purl.obolibrary.org/obo/GO_0034354`

(+)-abscisic acid 8’-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0010295`

(2E)-enoyl-CoA hydratase activity `http://purl.obolibrary.org/obo/GO_0080023`

(2S)-2-amino-5-[[amino(methylimino)methyl]amino]pentanoic acid `http://purl.obolibrary.org/obo/CHEBI_124959`

(2S)-2-ammonio-5-{[iminio(methylamino)methyl]amino}pentanoate `http://purl.obolibrary.org/obo/CHEBI_114953`

(3R)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0106386`

(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0003857`

(R)-2-hydroxyisocaproate dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0043713`

(R)-sulfopropanediol 2-dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0102157`

1,2-dehydro-N-acetyldopamine biosynthetic process `http://purl.obolibrary.org/obo/GO_0120577`

1,2-dehydro-N-beta-alanyldopamine biosynthetic process `http://purl.obolibrary.org/obo/GO_0120576`

1,2-dihydroxynaphthalene dioxygenase activity `http://purl.obolibrary.org/obo/GO_0018554`

1,8-cineole 2-exo-monooxygenase activity `http://purl.obolibrary.org/obo/GO_0102320`

1,8-cineole synthase activity `http://purl.obolibrary.org/obo/GO_0102313`

1-acylglycerol-3-phosphate O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0003841`

1-acylglycerophosphocholine O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0047184`

1-acylglycerophosphoethanolamine O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0106262`

1-acylglycerophosphoserine O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0106263`

1-alkenylglycerophosphoethanolamine O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0047166`

1-alkyl-2-acetylglycerol O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0047167`

1-alkylglycerophosphocholine O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0047191`

1-aminocyclopropane-1-carboxylate catabolic process `http://purl.obolibrary.org/obo/GO_0042217`

11-oxo-beta-amyrin 30-oxidase activity `http://purl.obolibrary.org/obo/GO_0102375`

2,4-dienoyl-CoA reductase (NADPH) activity `http://purl.obolibrary.org/obo/GO_0008670`

2,5-dioxovalerate dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0044104`

2,5-dioxovalerate dehydrogenase (NADP+) activity `http://purl.obolibrary.org/obo/GO_0047533`

2-(omega-methylthio)alkylmalate dehydratase activity `http://purl.obolibrary.org/obo/GO_0120528`

2-acylglycerol O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0003846`

2-acylglycerol-3-phosphate O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0047144`

2-acylglycerophosphocholine O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0047190`

2-aminobenzenesulfonate 2,3-dioxygenase activity `http://purl.obolibrary.org/obo/GO_0018627`

2-aminobenzenesulfonate catabolic process `http://purl.obolibrary.org/obo/GO_0046230`

2-dehydropantolactone reductase activity `http://purl.obolibrary.org/obo/GO_0036441`

2-hydroxyacyl-CoA lyase activity `http://purl.obolibrary.org/obo/GO_0106359`

2-hydroxyisocaproate CoA-transferase activity `http://purl.obolibrary.org/obo/GO_0043712`

2-hydroxyquinoline 5,6-dioxygenase activity `http://purl.obolibrary.org/obo/GO_0018629`

2-keto-3-deoxygluconate:proton symporter activity `http://purl.obolibrary.org/obo/GO_0015649`

24-methylenelophenol methyl oxidase activity `http://purl.obolibrary.org/obo/GO_0102177`

3’-phosphoadenosine 5’-phosphosulfate transport `http://purl.obolibrary.org/obo/GO_0046963`

3,9-dihydroxypterocarpan 6a-monooxygenase activity `http://purl.obolibrary.org/obo/GO_0047082`

3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] activity `http://purl.obolibrary.org/obo/GO_0140169`

3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0003854`

3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity `http://purl.obolibrary.org/obo/GO_0102175`

3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity `http://purl.obolibrary.org/obo/GO_0000252`

3-butenylglucosinolate 2-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0062131`

3-chlorobenzoate-3,4-oxygenase activity `http://purl.obolibrary.org/obo/GO_0102045`

3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity `http://purl.obolibrary.org/obo/GO_0017060`

3-hydroxy-2-methylpyridinecarboxylate dioxygenase activity `http://purl.obolibrary.org/obo/GO_0047081`

3-hydroxyacyl-CoA dehydratase activity `http://purl.obolibrary.org/obo/GO_0018812`

3-oxoadipate CoA-transferase activity `http://purl.obolibrary.org/obo/GO_0047569`

3-phenylpropionate dioxygenase activity `http://purl.obolibrary.org/obo/GO_0008695`

3-sulfino-L-alanine: proton, glutamate antiporter activity `http://purl.obolibrary.org/obo/GO_0000514`

3alpha-hydroxy-ent-sandaracopimardiene 7-beta-monooxygenase activity `http://purl.obolibrary.org/obo/GO_0102598`

3alpha-hydroxy-ent-sandaracopimardiene 9-beta-monooxygenase activity `http://purl.obolibrary.org/obo/GO_0102597`

3beta-hydroxy-5alpha-ergosta-7,24(28)-diene-4alpha-carboxylate `http://purl.obolibrary.org/obo/CHEBI_142850`

3beta-hydroxy-5alpha-ergosta-7,24(28)-diene-4alpha-carboxylic acid `http://purl.obolibrary.org/obo/CHEBI_145340`