go-ontology

Ontology comparison

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Ontology IRI: http://purl.obolibrary.org/obo/go.owl
Version IRI: http://purl.obolibrary.org/obo/go/releases/2026-07-26/go.owl
Loaded from: file:/__w/go-ontology/go-ontology/src/ontology/go-lastrelease.owl

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Ontology IRI: http://purl.obolibrary.org/obo/go.owl
Version IRI: http://purl.obolibrary.org/obo/go/releases/2026-09-13/go.owl
Loaded from: file:/__w/go-ontology/go-ontology/src/ontology/go.ofn

Ontology imports

Ontology annotations

Removed

versionInfo “2026-07-26”

Added

versionInfo “2026-09-13”

‘de novo’ NAD+ biosynthetic process from L-tryptophan `http://purl.obolibrary.org/obo/GO_0034354`

Added

‘de novo’ NAD+ biosynthetic process from L-tryptophan term tracker item “https://github.com/geneontology/go-ontology/issues/32456”^^anyURI

(2R)-2-hydroxycarboxylate dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0140174`

Removed

(2R)-2-hydroxycarboxylate dehydrogenase activity label “(2R)-2-hydroxycarboxylate dehydrogenase activity”

Added

(2R)-2-hydroxycarboxylate dehydrogenase activity has_broad_synonym “(2R)-2-hydroxycarboxylate dehydrogenase activity”
(2R)-2-hydroxycarboxylate dehydrogenase activity label “(2R)-2-hydroxycarboxylate dehydrogenase (FAD) activity”

(R)-mandelate dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0097620`

Removed

(R)-mandelate dehydrogenase activity has_exact_synonym “D-mandelate dehydrogenase activity”
(R)-mandelate dehydrogenase activity label “(R)-mandelate dehydrogenase activity”
(R)-mandelate dehydrogenase activity SubClassOf oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Added

(R)-mandelate dehydrogenase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32501”^^anyURI
(R)-mandelate dehydrogenase activity has_broad_synonym “(R)-mandelate dehydrogenase activity”
(R)-mandelate dehydrogenase activity has_broad_synonym “D-mandelate dehydrogenase activity”
(R)-mandelate dehydrogenase activity label “(R)-mandelate dehydrogenase (NAD+) activity”
(R)-mandelate dehydrogenase activity SubClassOf (2R)-2-hydroxyacid dehydrogenase (NAD+) activity

1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0062181`

Removed

1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity definition “Catatlysis of the reaction: calcitriol + 2 H+ + O2 + 2 reduced [adrenodoxin] = 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin].”
- database_cross_reference “PMID:22100522”
- database_cross_reference “RHEA:49192”
- database_cross_reference “PMID:30205156”

Added

1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity definition “Catalysis of the reaction: calcitriol + 2 H+ + O2 + 2 reduced [adrenodoxin] = 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin].”
- database_cross_reference “PMID:22100522”
- database_cross_reference “RHEA:49192”
- database_cross_reference “PMID:30205156”

10-formyltetrahydrofolate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009257`

Removed

10-formyltetrahydrofolate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate.”
- database_cross_reference “GOC:ai”
10-formyltetrahydrofolate biosynthetic process label “10-formyltetrahydrofolate biosynthetic process”
10-formyltetrahydrofolate biosynthetic process SubClassOf 10-formyltetrahydrofolate metabolic process
10-formyltetrahydrofolate biosynthetic process SubClassOf dicarboxylic acid biosynthetic process
10-formyltetrahydrofolate biosynthetic process SubClassOf tetrahydrofolate biosynthetic process

Added

10-formyltetrahydrofolate biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/32289”^^anyURI
10-formyltetrahydrofolate biosynthetic process term replaced by tetrahydrofolate interconversion
10-formyltetrahydrofolate biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate.”
- database_cross_reference “GOC:ai”
10-formyltetrahydrofolate biosynthetic process deprecated true
10-formyltetrahydrofolate biosynthetic process comment “This term was obsoleted because it represents the same process as folate cycle ; GO:0035999.”
10-formyltetrahydrofolate biosynthetic process label “obsolete 10-formyltetrahydrofolate biosynthetic process”

2-(3-amino-3-carboxypropyl)histidine synthase complex `http://purl.obolibrary.org/obo/GO_0120513`

Removed

2-(3-amino-3-carboxypropyl)histidine synthase complex definition “A protein complex capable of catalysing the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the histidine residue of translation elongation factor 2 (EF2), which is the first step in the biosynthesis of diphthamide. The complex is a Dph2 homodimer in archaea and a Dph1-Dph2 heterodimer in eukaryotes.”
- database_cross_reference “GOC:sjm”
- database_cross_reference “PMID:31463593”
- database_cross_reference “PMID:24422557”

Added

2-(3-amino-3-carboxypropyl)histidine synthase complex definition “A protein complex capable of catalyzing the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the histidine residue of translation elongation factor 2 (EF2), which is the first step in the biosynthesis of diphthamide. The complex is a Dph2 homodimer in archaea and a Dph1-Dph2 heterodimer in eukaryotes.”
- database_cross_reference “GOC:sjm”
- database_cross_reference “PMID:31463593”
- database_cross_reference “PMID:24422557”

2-oxoadipate decarboxylation to glutaryl-CoA `http://purl.obolibrary.org/obo/GO_0120578`

Added

Class: 2-oxoadipate decarboxylation to glutaryl-CoA
2-oxoadipate decarboxylation to glutaryl-CoA term tracker item “https://github.com/geneontology/go-ontology/issues/32557”^^anyURI
2-oxoadipate decarboxylation to glutaryl-CoA created by “sjm”
2-oxoadipate decarboxylation to glutaryl-CoA creation date “2026-09-03T06:52:01Z”
2-oxoadipate decarboxylation to glutaryl-CoA has_obo_namespace “biological_process”
2-oxoadipate decarboxylation to glutaryl-CoA id “GO:0120578”
2-oxoadipate decarboxylation to glutaryl-CoA definition “The chemical reactions and pathways resulting in the formation of glutaryl-CoA from 2-oxoadipate. In most organisms, this pathway is part of L-lysine, L-hydroxylysine and L-tryptophan degradation and comprises a series of three reactions carried out by a multisubunit complex called the ‘2-oxoadipate dehydrogenase complex’, even though 2-oxoadipate dehydrogenase activity describes only one of those reactions. The combination of the three reactions can be summarized as: 2-oxoadipate + coenzyme A + NAD+ -> glutaryl-CoA + CO2 + NADH.”
- database_cross_reference “PMID:29191460”
2-oxoadipate decarboxylation to glutaryl-CoA label “2-oxoadipate decarboxylation to glutaryl-CoA”
2-oxoadipate decarboxylation to glutaryl-CoA SubClassOf dicarboxylic acid metabolic process
2-oxoadipate decarboxylation to glutaryl-CoA SubClassOf acyl-CoA biosynthetic process
2-oxoadipate decarboxylation to glutaryl-CoA SubClassOf fatty acid derivative biosynthetic process

2-oxoadipate dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0160166`

Added

2-oxoadipate dehydrogenase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32557”^^anyURI
2-oxoadipate dehydrogenase activity broadMatch 30795

4’-phosphopantetheine phosphatase activity `http://purl.obolibrary.org/obo/GO_7770095`

Added

Class: 4’-phosphopantetheine phosphatase activity
4’-phosphopantetheine phosphatase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32389”^^anyURI
4’-phosphopantetheine phosphatase activity created by “ai4c-agent”
4’-phosphopantetheine phosphatase activity creation date “2026-07-30T17:40:49Z”
4’-phosphopantetheine phosphatase activity database_cross_reference “EC:3.1.3.110”
4’-phosphopantetheine phosphatase activity database_cross_reference “KEGG_REACTION:R10748”
4’-phosphopantetheine phosphatase activity database_cross_reference “MetaCyc:RXN-24222”
4’-phosphopantetheine phosphatase activity database_cross_reference “RHEA:68328”
4’-phosphopantetheine phosphatase activity has_exact_synonym “pantetheine-4’-phosphate phosphatase activity”
4’-phosphopantetheine phosphatase activity has_exact_synonym “phosphopantetheine phosphatase activity”
4’-phosphopantetheine phosphatase activity has_obo_namespace “molecular_function”
4’-phosphopantetheine phosphatase activity id “GO:7770095”
4’-phosphopantetheine phosphatase activity exactMatch RXN-24222
4’-phosphopantetheine phosphatase activity exactMatch 3.1.3.110
4’-phosphopantetheine phosphatase activity exactMatch 68328
4’-phosphopantetheine phosphatase activity definition “Catalysis of the reaction: (R)-4’-phosphopantetheine + H2O = (R)-pantetheine + phosphate.”
- database_cross_reference “EC:3.1.3.110”
- database_cross_reference “PMID:18678912”
- database_cross_reference “PMID:35896750”
- database_cross_reference “PMID:27322068”
- database_cross_reference “RHEA:68328”
4’-phosphopantetheine phosphatase activity label “4’-phosphopantetheine phosphatase activity”
4’-phosphopantetheine phosphatase activity SubClassOf phosphatase activity

4-chlorobenzoate dehalogenase activity `http://purl.obolibrary.org/obo/GO_0047576`

Removed

4-chlorobenzoate dehalogenase activity database_cross_reference “EC:3.8.1.6”
4-chlorobenzoate dehalogenase activity database_cross_reference “KEGG_REACTION:R01307”
4-chlorobenzoate dehalogenase activity database_cross_reference “MetaCyc:4-CHLOROBENZOATE-DEHALOGENASE-RXN”
4-chlorobenzoate dehalogenase activity database_cross_reference “RHEA:23440”
4-chlorobenzoate dehalogenase activity exactMatch 3.8.1.6
4-chlorobenzoate dehalogenase activity exactMatch 23440
4-chlorobenzoate dehalogenase activity definition “Catalysis of the reaction: 4-chlorobenzoate + H2O = 4-hydroxybenzoate + chloride + H+.”
- database_cross_reference “RHEA:23440”
4-chlorobenzoate dehalogenase activity label “4-chlorobenzoate dehalogenase activity”
4-chlorobenzoate dehalogenase activity SubClassOf hydrolase activity, acting on halide bonds, in C-halide compounds

Added

4-chlorobenzoate dehalogenase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32542”^^anyURI
4-chlorobenzoate dehalogenase activity consider 4-hydroxybenzoyl-CoA thioesterase activity
4-chlorobenzoate dehalogenase activity consider 4-chlorobenzoyl-CoA dehalogenase activity
4-chlorobenzoate dehalogenase activity consider 4-chlorobenzoate-CoA ligase activity
4-chlorobenzoate dehalogenase activity definition “OBSOLETE. Catalysis of the reaction: 4-chlorobenzoate + H2O = 4-hydroxybenzoate + chloride + H+.”
- database_cross_reference “RHEA:23440”
4-chlorobenzoate dehalogenase activity deprecated true
4-chlorobenzoate dehalogenase activity comment “The reason for obsoletion is that this activity is not known to be catalyzed by any gene product, there is no evidence that this function/process/component exists, and the EC number (EC 3.8.1.6) on which this GO term was based has been deleted in the IUBMB EC list.”
4-chlorobenzoate dehalogenase activity label “obsolete 4-chlorobenzoate dehalogenase activity”

6-phosphofructokinase activity `http://purl.obolibrary.org/obo/GO_0003872`

Removed

6-phosphofructokinase activity SubClassOf part of some glycolytic process through fructose-6-phosphate

Added

6-phosphofructokinase activity SubClassOf part of some glycolytic process

7-methylguanosine cap hypermethylation `http://purl.obolibrary.org/obo/GO_0036261`

Removed

7-methylguanosine cap hypermethylation definition “Hypermethylation of the 7-(mono)methylguanosine (m(7)G) cap structure at the 2’ position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. This type of cap modification occurs on small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs) and is dependent on prior guanine-N7 methylation.”
- database_cross_reference “PMID:11983179”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:krc”
- database_cross_reference “GOC:rl”
- database_cross_reference “GOC:BHF”
- database_cross_reference “PMID:18775984”

Added

7-methylguanosine cap hypermethylation term tracker item “https://github.com/geneontology/go-ontology/issues/27628”^^anyURI
7-methylguanosine cap hypermethylation definition “Hypermethylation of the 7-(mono)methylguanosine (m(7)G) cap structure at the N2 position of the guanine base to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. This type of cap modification occurs on small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs) and is dependent on prior guanine-N7 methylation.”
- database_cross_reference “PMID:15590684”
- database_cross_reference “PMID:11983179”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:krc”
- database_cross_reference “GOC:rl”
- database_cross_reference “GOC:BHF”
- database_cross_reference “PMID:18775984”

ABC-type cadmium transporter activity `http://purl.obolibrary.org/obo/GO_0015434`

Added

ABC-type cadmium transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/20824”^^anyURI
ABC-type cadmium transporter activity broadMatch 12132
ABC-type cadmium transporter activity comment “Note that RHEA:12132 represents both the ABC and the P-type cadmium transporters.”

ABC-type protein transporter activity `http://purl.obolibrary.org/obo/GO_0015462`

Removed

ABC-type protein transporter activity definition “Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein(out) = ADP + phosphate + protein(in).”
- database_cross_reference “GOC:jl”

Added

ABC-type protein transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/32395”^^anyURI
ABC-type protein transporter activity definition “Enables the transfer of a protein from one side of a membrane to the other according to the reaction: ATP + H2O + protein(out) = ADP + phosphate + protein(in).”
- database_cross_reference “GOC:jl”

ATG2-ATG18 complex `http://purl.obolibrary.org/obo/GO_0062079`

Removed

ATG2-ATG18 complex SubClassOf part of some phagophore assembly site membrane

Added

ATG2-ATG18 complex term tracker item “https://github.com/geneontology/go-ontology/issues/29437”^^anyURI
ATG2-ATG18 complex SubClassOf part of some phagophore membrane

ATP-dependent folded protein transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_7770098`

Added

Class: ATP-dependent folded protein transmembrane transporter activity
ATP-dependent folded protein transmembrane transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/32394”^^anyURI
ATP-dependent folded protein transmembrane transporter activity created by “ai4c-agent”
ATP-dependent folded protein transmembrane transporter activity creation date “2026-08-04T00:40:41Z”
ATP-dependent folded protein transmembrane transporter activity has_exact_synonym “ATPase-coupled folded protein transmembrane transporter activity”
ATP-dependent folded protein transmembrane transporter activity has_exact_synonym “folded protein-transporting ATPase activity”
ATP-dependent folded protein transmembrane transporter activity has_obo_namespace “molecular_function”
ATP-dependent folded protein transmembrane transporter activity has_related_synonym “folded protein translocase activity”
ATP-dependent folded protein transmembrane transporter activity id “GO:7770098”
ATP-dependent folded protein transmembrane transporter activity definition “Enables the transfer of a protein in its native, folded conformation from one side of a membrane to the other, coupled to the hydrolysis of ATP and without unfolding of the substrate, according to the reaction: ATP + H2O + protein[side 1] = ADP + phosphate + protein[side 2].”
- database_cross_reference “PMID:32042153”
- database_cross_reference “PMID:40410623”
- database_cross_reference “PMID:31988523”
ATP-dependent folded protein transmembrane transporter activity comment “This activity is exemplified by the mitochondrial inner membrane AAA-ATPase Bcs1 (BCS1L in mammals), which translocates the folded, 2Fe-2S-loaded Rieske iron-sulfur protein from the mitochondrial matrix across the inner membrane during respiratory complex III assembly. Unlike most AAA+ protein translocases, the substrate is not threaded through an axial pore in an extended conformation; in Bcs1 it passes between two aqueous vestibules separated by a seal, in an airlock-like mechanism that preserves the membrane permeability barrier. Do not use this term for the separable channel and motor activities of multi-subunit translocases; for those, consider ‘transmembrane protein transporter activity ; GO:0008320’ and ‘protein translocation chaperone activity ; GO:0140388’.”
ATP-dependent folded protein transmembrane transporter activity label “ATP-dependent folded protein transmembrane transporter activity”
ATP-dependent folded protein transmembrane transporter activity SubClassOf protein-transporting ATPase activity

ATP-dependent protein-RNA complex displacement activity `http://purl.obolibrary.org/obo/GO_7770106`

Added

Class: ATP-dependent protein-RNA complex displacement activity
ATP-dependent protein-RNA complex displacement activity term tracker item “https://github.com/geneontology/go-ontology/issues/32232”^^anyURI
ATP-dependent protein-RNA complex displacement activity created by “ai4c-agent”
ATP-dependent protein-RNA complex displacement activity creation date “2026-08-07T16:59:22Z”
ATP-dependent protein-RNA complex displacement activity has_broad_synonym “RNP remodeling ATPase activity”
ATP-dependent protein-RNA complex displacement activity has_exact_synonym “ATP-dependent RNA-protein complex displacement activity”
ATP-dependent protein-RNA complex displacement activity has_exact_synonym “RNPase activity”
ATP-dependent protein-RNA complex displacement activity has_obo_namespace “molecular_function”
ATP-dependent protein-RNA complex displacement activity id “GO:7770106”
ATP-dependent protein-RNA complex displacement activity definition “An activity that displaces a protein or protein complex from RNA in a ribonucleoprotein (RNP) complex, driven by ATP hydrolysis.”
- database_cross_reference “PMID:28864812”
- database_cross_reference “PMID:11175897”
- database_cross_reference “PMID:39122693”
- database_cross_reference “PMID:15118161”
ATP-dependent protein-RNA complex displacement activity comment “Analogous to the DNA-side activity GO:0061995 (ATP-dependent protein-DNA complex displacement activity). The community-used term "RNPase" refers to this activity.”
ATP-dependent protein-RNA complex displacement activity label “ATP-dependent protein-RNA complex displacement activity”
ATP-dependent protein-RNA complex displacement activity SubClassOf ATP-dependent activity, acting on RNA

ATPase-coupled L-glutamate tranmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0102013`

Removed

ATPase-coupled L-glutamate tranmembrane transporter activity label “ATPase-coupled L-glutamate tranmembrane transporter activity”

Added

ATPase-coupled L-glutamate tranmembrane transporter activity label “ATPase-coupled L-glutamate transmembrane transporter activity”

Atg9-containing vesicle `http://purl.obolibrary.org/obo/GO_7770115`

Added

Class: Atg9-containing vesicle
Atg9-containing vesicle term tracker item “https://github.com/geneontology/go-ontology/issues/29437”^^anyURI
Atg9-containing vesicle created by “ai4c-agent”
Atg9-containing vesicle creation date “2026-08-20T23:57:41Z”
Atg9-containing vesicle has_exact_synonym “Atg9 vesicle”
Atg9-containing vesicle has_narrow_synonym “ATG9A vesicle”
Atg9-containing vesicle has_obo_namespace “cellular_component”
Atg9-containing vesicle id “GO:7770115”
Atg9-containing vesicle has_related_synonym “Atg9-containing compartment”
- database_cross_reference “PMID:20855505”
Atg9-containing vesicle definition “A small, single-membrane cytoplasmic vesicle that carries the transmembrane autophagy protein Atg9 (ATG9A in mammals). Vesicles of this type are derived from the Golgi apparatus and from endosomal compartments, and can be delivered to the phagophore assembly site, where they contribute membrane to the nascent phagophore.”
- database_cross_reference “PMID:22826123”
- database_cross_reference “PMID:20855505”
- database_cross_reference “PMID:24034251”
- database_cross_reference “PMID:32883836”
Atg9-containing vesicle comment “In Saccharomyces cerevisiae these vesicles are 30-60 nm in diameter and approximately three are consumed per autophagosome. In mammals ATG9A vesicles traffic via the trans-Golgi network and recycling endosomes, and a substantial part of the pool is not engaged in autophagosome formation at any given time. Use this term for the vesicle itself, at any stage of its itinerary. Membrane that has been incorporated into the phagophore is phagophore membrane (GO:7770114) rather than a vesicle. The Atg9-containing compartment/reservoir described by Mari et al. (PMID:20855505) is a cluster of these vesicles and tubules rather than a single vesicle; use this term for the individual vesicles that make up such clusters.”
Atg9-containing vesicle label “Atg9-containing vesicle”
Atg9-containing vesicle SubClassOf cytoplasmic vesicle

B cell tolerance induction in mucosal-associated lymphoid tissue `http://purl.obolibrary.org/obo/GO_0002402`

Removed

B cell tolerance induction in mucosal-associated lymphoid tissue definition “Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by B cells.”
- database_cross_reference “ISBN:0781735149”
- database_cross_reference “GOC:jal”

Added

B cell tolerance induction in mucosal-associated lymphoid tissue term tracker item “https://github.com/geneontology/go-ontology/issues/20574”^^anyURI
B cell tolerance induction in mucosal-associated lymphoid tissue definition “Tolerance induction taking place in a B cell within the mucosal-associated lymphoid tissue (MALT).”
- database_cross_reference “ISBN:0781735149”
- database_cross_reference “GOC:jal”

B-type glycerophospholipase activity `http://purl.obolibrary.org/obo/GO_0102545`

Removed

B-type glycerophospholipase activity definition “A glycerophospholipase activity that cleaves both fatty acisd attached to the sn-1 and the sn-2 position of the glycerol group of a glycerophospholipid. Substrates include phosphatidylcholine and phosphatidylethanolamine.”
- database_cross_reference “PMID:30109646”

Added

B-type glycerophospholipase activity definition “A glycerophospholipase activity that cleaves both fatty acids attached to the sn-1 and the sn-2 position of the glycerol group of a glycerophospholipid. Substrates include phosphatidylcholine and phosphatidylethanolamine.”
- database_cross_reference “PMID:30109646”

D-glucosamine biosynthetic process `http://purl.obolibrary.org/obo/GO_0006042`

Removed

D-glucosamine biosynthetic process SubClassOf D-glucosamine metabolic process

D-glucosamine catabolic process `http://purl.obolibrary.org/obo/GO_0006043`

Removed

D-glucosamine catabolic process SubClassOf D-glucosamine metabolic process

D-glucosamine metabolic process `http://purl.obolibrary.org/obo/GO_0006041`

Removed

D-glucosamine metabolic process definition “The chemical reactions and pathways involving glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin.”
- database_cross_reference “GOC:jl”
- database_cross_reference “ISBN:0198506732”
D-glucosamine metabolic process label “D-glucosamine metabolic process”
D-glucosamine metabolic process SubClassOf amino sugar metabolic process

Added

D-glucosamine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/32273”^^anyURI
D-glucosamine metabolic process consider D-glucosamine biosynthetic process
D-glucosamine metabolic process consider D-glucosamine catabolic process
D-glucosamine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin.”
- database_cross_reference “GOC:jl”
- database_cross_reference “ISBN:0198506732”
D-glucosamine metabolic process deprecated true
D-glucosamine metabolic process comment “The reason for obsoletion is that these terms were added in error.”
D-glucosamine metabolic process label “obsolete D-glucosamine metabolic process”

D-lactate dehydrogenase (FAD) activity `http://purl.obolibrary.org/obo/GO_0140170`

Added

D-lactate dehydrogenase (FAD) activity term tracker item “https://github.com/geneontology/go-ontology/issues/32501”^^anyURI
D-lactate dehydrogenase (FAD) activity SubClassOf (2R)-2-hydroxycarboxylate dehydrogenase activity

D-sorbitol biosynthetic process `http://purl.obolibrary.org/obo/GO_0006061`

Added

D-sorbitol biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/32269”^^anyURI

D-xylose reductase (NADPH) activity `http://purl.obolibrary.org/obo/GO_0032866`

Added

D-xylose reductase (NADPH) activity term tracker item “https://github.com/geneontology/go-ontology/issues/27881”^^anyURI
D-xylose reductase (NADPH) activity SubClassOf alcohol dehydrogenase (NADP+) activity

DNA ADP-ribosylation `http://purl.obolibrary.org/obo/GO_0030592`

Removed

DNA ADP-ribosylation definition “The covalent attachment of an ADP-ribosyl group to a residue in double-stranded DNA.”
- database_cross_reference “PMID:11592983”
- database_cross_reference “PMID:27471034”
- database_cross_reference “PMID:29520010”
- database_cross_reference “PMID:29361132”
DNA ADP-ribosylation label “DNA ADP-ribosylation”
DNA ADP-ribosylation SubClassOf DNA modification

Added

DNA ADP-ribosylation term tracker item “https://github.com/geneontology/go-ontology/issues/32538”^^anyURI
DNA ADP-ribosylation consider NAD DNA ADP-ribosyltransferase activity
DNA ADP-ribosylation definition “OBSOLETE. The covalent attachment of an ADP-ribosyl group to a residue in double-stranded DNA.”
- database_cross_reference “PMID:11592983”
- database_cross_reference “PMID:27471034”
- database_cross_reference “PMID:29520010”
- database_cross_reference “PMID:29361132”
DNA ADP-ribosylation deprecated true
DNA ADP-ribosylation comment “This term was obsoleted because it represents a molecular function.”
DNA ADP-ribosylation label “obsolete DNA ADP-ribosylation”

DNA recombinase auxiliary factor complex `http://purl.obolibrary.org/obo/GO_0120231`

Removed

DNA recombinase auxiliary factor complex definition “A protein complex that binds to a recombinase and incrseases its activity.”
- database_cross_reference “PMID:32414915”

Added

DNA recombinase auxiliary factor complex definition “A protein complex that binds to a recombinase and increases its activity.”
- database_cross_reference “PMID:32414915”

ER lumen protein retrieval receptor activity `http://purl.obolibrary.org/obo/GO_0046923`

Removed

ER lumen protein retrieval receptor activity has_exact_synonym “endoplasmic reticulum retention sequence binding”
ER lumen protein retrieval receptor activity has_narrow_synonym “DDEL signal sequence receptor activity”
ER lumen protein retrieval receptor activity has_narrow_synonym “ER retention sequence binding”
ER lumen protein retrieval receptor activity has_narrow_synonym “HDEL signal sequence receptor activity”
ER lumen protein retrieval receptor activity has_narrow_synonym “KDEL signal sequence receptor activity”
ER lumen protein retrieval receptor activity definition “Binding to an endoplasmic reticulum (ER) retention sequence, a short stretch of amino acids found in a protein that acts as a signal to retain the protein within the ER.”
- database_cross_reference “GOC:ai”
ER lumen protein retrieval receptor activity SubClassOf signal sequence receptor activity

Added

ER lumen protein retrieval receptor activity term tracker item “https://github.com/geneontology/go-ontology/issues/32307”^^anyURI
ER lumen protein retrieval receptor activity has_related_synonym “DDEL signal sequence receptor activity”
ER lumen protein retrieval receptor activity has_related_synonym “ER retention sequence binding”
ER lumen protein retrieval receptor activity has_related_synonym “HDEL signal sequence receptor activity”
ER lumen protein retrieval receptor activity has_related_synonym “KDEL signal sequence receptor activity”
ER lumen protein retrieval receptor activity has_related_synonym “endoplasmic reticulum retention sequence binding”
ER lumen protein retrieval receptor activity definition “Binding to a C-terminal ER retrieval signal, such as KDEL, HDEL or DDEL, present on soluble lumenal proteins that have escaped from the endoplasmic reticulum (ER) to the Golgi, and mediating their return to the ER.”
- database_cross_reference “PMID:33037041”
ER lumen protein retrieval receptor activity SubClassOf cargo receptor activity
ER lumen protein retrieval receptor activity SubClassOf part of some retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

ER membrane protein retrieval receptor activity `http://purl.obolibrary.org/obo/GO_7770094`

Added

Class: ER membrane protein retrieval receptor activity
ER membrane protein retrieval receptor activity term tracker item “https://github.com/geneontology/go-ontology/issues/32307”^^anyURI
ER membrane protein retrieval receptor activity created by “ai4c-agent”
ER membrane protein retrieval receptor activity creation date “2026-07-29T19:05:05Z”
ER membrane protein retrieval receptor activity has_exact_synonym “endoplasmic reticulum membrane protein retrieval receptor activity”
ER membrane protein retrieval receptor activity has_narrow_synonym “KKXX motif binding”
ER membrane protein retrieval receptor activity has_narrow_synonym “KKXX signal receptor activity”
ER membrane protein retrieval receptor activity has_narrow_synonym “dilysine motif binding”
ER membrane protein retrieval receptor activity has_obo_namespace “molecular_function”
ER membrane protein retrieval receptor activity id “GO:7770094”
ER membrane protein retrieval receptor activity definition “Binding to a retrieval signal, such as a C-terminal KKXX/KXKX-type dilysine motif or an exposed transmembrane domain determinant, present on integral membrane proteins that have escaped from the endoplasmic reticulum (ER) to the Golgi, and mediating their return to the ER.”
- database_cross_reference “PMID:12972550”
ER membrane protein retrieval receptor activity label “ER membrane protein retrieval receptor activity”
ER membrane protein retrieval receptor activity SubClassOf cargo receptor activity
ER membrane protein retrieval receptor activity SubClassOf part of some retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

ER overload response `http://purl.obolibrary.org/obo/GO_0006983`

Added

ER overload response term tracker item “https://github.com/geneontology/go-ontology/issues/20914”^^anyURI
ER overload response SubClassOf part of some endoplasmic reticulum protein quality control

ERAD pathway `http://purl.obolibrary.org/obo/GO_0036503`

Removed

ERAD pathway definition “The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:PARL”
- database_cross_reference “PMID:20940304”
- database_cross_reference “PMID:21969857”
ERAD pathway has_exact_synonym “protein degradation by ERAD”
- database_cross_reference “GOC:bf”
ERAD pathway has_exact_synonym “endoplasmic reticulum-associated degradation”
- database_cross_reference “PMID:22535891”
ERAD pathway label “ERAD pathway”
ERAD pathway SubClassOf response to endoplasmic reticulum stress
ERAD pathway SubClassOf response to chemical

Added

ERAD pathway term tracker item “https://github.com/geneontology/go-ontology/issues/20914”^^anyURI
ERAD pathway term tracker item “https://github.com/geneontology/go-ontology/issues/32527”^^anyURI
ERAD pathway term tracker item “https://github.com/geneontology/go-ontology/issues/32532”^^anyURI
ERAD pathway has_broad_synonym “ERAD pathway”
ERAD pathway definition “The protein catabolic pathway which constitutively monitors and targets misfolded/aberrant endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:PARL”
- database_cross_reference “PMID:20940304”
- database_cross_reference “PMID:21969857”
ERAD pathway has_broad_synonym “protein degradation by ERAD”
- database_cross_reference “GOC:bf”
ERAD pathway has_broad_synonym “endoplasmic reticulum-associated degradation”
- database_cross_reference “PMID:22535891”
ERAD pathway label “ERAD quality control pathway”
ERAD pathway SubClassOf endoplasmic reticulum protein quality control

ESCRT III complex `http://purl.obolibrary.org/obo/GO_0000815`

Removed

ESCRT III complex definition “A complex with membrane scission activity that plays a major role in many processes where membranes are remodelled - including endosomal transport (vesicle budding), nuclear envelope organisation (membrane closure, mitotic bridge cleavage), and cytokinesis (abscission).”
- database_cross_reference “PMID:32243490”
- database_cross_reference “PMID:22361144”
- database_cross_reference “PMID:28242692”
- database_cross_reference “PMID:31132588”
- database_cross_reference “PMID:17556548”
- database_cross_reference “PMID:34449766”

Added

ESCRT III complex definition “A complex with membrane scission activity that plays a major role in many processes where membranes are remodelled - including endosomal transport (vesicle budding), nuclear envelope organization (membrane closure, mitotic bridge cleavage), and cytokinesis (abscission).”
- database_cross_reference “PMID:32243490”
- database_cross_reference “PMID:22361144”
- database_cross_reference “PMID:28242692”
- database_cross_reference “PMID:31132588”
- database_cross_reference “PMID:17556548”
- database_cross_reference “PMID:34449766”

FAD regeneration via ETF:ETFQO system `http://purl.obolibrary.org/obo/GO_7770096`

Added

Class: FAD regeneration via ETF:ETFQO system
FAD regeneration via ETF:ETFQO system term tracker item “https://github.com/geneontology/go-ontology/issues/32355”^^anyURI
FAD regeneration via ETF:ETFQO system created by “ai4c-agent”
FAD regeneration via ETF:ETFQO system creation date “2026-07-30T22:03:00Z”
FAD regeneration via ETF:ETFQO system has_exact_synonym “ETF-ETFQO system”
FAD regeneration via ETF:ETFQO system has_exact_synonym “FAD regeneration via ETF-ETFQO system”
FAD regeneration via ETF:ETFQO system has_exact_synonym “reoxidation of reduced electron transfer flavoprotein”
FAD regeneration via ETF:ETFQO system has_obo_namespace “biological_process”
FAD regeneration via ETF:ETFQO system id “GO:7770096”
FAD regeneration via ETF:ETFQO system definition “A metabolic process that transfers electrons produced by FAD-dependent dehydrogenases involved in amino acid and lipid catabolism to the electron transport chain. Electrons released during FADH2 oxidation are transferred by electron-transfer flavoprotein (ETF) to ETF-ubiquinone oxidoreductase (ETF-QO), which in turn transfers them to ubiquinone and then to complex III of the electron transport chain.”
- database_cross_reference “PMID:28808132”
- database_cross_reference “PMID:33450351”
FAD regeneration via ETF:ETFQO system comment “In eukaryotes, FAD regeneration via the ETF:ETFQO system occurs in the mitochondrion, with ETF in the matrix and ETF-QO in the inner membrane. Some bacteria and archaea have a similar system, so no taxon constraint applies to this term. This term covers the ETF/ETF-QO route specifically; do not use it for flavoprotein dehydrogenases that reduce the quinone pool directly without ETF (for example succinate dehydrogenase, see GO:0006121), or for reoxidation of flavin by molecular oxygen in peroxisomes or the endoplasmic reticulum.”
FAD regeneration via ETF:ETFQO system label “FAD regeneration via ETF:ETFQO system”
FAD regeneration via ETF:ETFQO system SubClassOf respiratory electron transport chain
FAD regeneration via ETF:ETFQO system SubClassOf FAD metabolic process

FMN adenylyltransferase activity `http://purl.obolibrary.org/obo/GO_0003919`

Removed

FMN adenylyltransferase activity definition “Catalysis of the reaction: ATP + FMN = diphosphate + FAD.”
- database_cross_reference “EC:2.7.7.2”
- database_cross_reference “RHEA:17237”

Added

FMN adenylyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32345”^^anyURI
FMN adenylyltransferase activity definition “Catalysis of the reaction: FMN + ATP + H+ = FAD + diphosphate.”
- database_cross_reference “RHEA:17237”

G-protein beta/gamma-subunit complex `http://purl.obolibrary.org/obo/GO_0031680`

Removed

G-protein beta/gamma-subunit complex definition “The heterodimer formed by the beta and gamma subunits of a heterotrimeric G protein, which dissociates from the alpha subunit upon guanine nuclotide exchange.”
- database_cross_reference “GOC:mah”

Added

G-protein beta/gamma-subunit complex definition “The heterodimer formed by the beta and gamma subunits of a heterotrimeric G protein, which dissociates from the alpha subunit upon guanine nucleotide exchange.”
- database_cross_reference “GOC:mah”

GPI anchor remodelling `http://purl.obolibrary.org/obo/GO_0120574`

Removed

GPI anchor remodelling label “GPI anchor remodelling”

Added

GPI anchor remodelling label “GPI anchor remodeling”

Hrd1p ubiquitin ligase complex `http://purl.obolibrary.org/obo/GO_0000836`

Removed

Hrd1p ubiquitin ligase complex definition “A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. In mammals, this complex contains the ubiquitin ligase HRD1 (Synoviolin) or AMFR (gp78).”
- database_cross_reference “GOC:elh”
- database_cross_reference “GOC:bf”
- database_cross_reference “PMID:16619026”
- database_cross_reference “PMID:16873066”
- database_cross_reference “PMID:21454652”

Added

Hrd1p ubiquitin ligase complex term tracker item “https://github.com/geneontology/go-ontology/issues/32529”^^anyURI
Hrd1p ubiquitin ligase complex definition “A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. In mammals, this complex contains the ubiquitin ligase HRD1 (Synoviolin).”
- database_cross_reference “GOC:elh”
- database_cross_reference “PMID:20100910”
- database_cross_reference “GOC:bf”
- database_cross_reference “PMID:16619026”
- database_cross_reference “PMID:16873066”
- database_cross_reference “PMID:21454652”

L-arabinose reductase (NADPH) activity `http://purl.obolibrary.org/obo/GO_0032867`

Added

L-arabinose reductase (NADPH) activity term tracker item “https://github.com/geneontology/go-ontology/issues/27881”^^anyURI
L-arabinose reductase (NADPH) activity SubClassOf alcohol dehydrogenase (NADP+) activity

L-malate dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0030060`

Removed

L-malate dehydrogenase (NAD+) activity SubClassOf oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Added

L-malate dehydrogenase (NAD+) activity term tracker item “https://github.com/geneontology/go-ontology/issues/32501”^^anyURI
L-malate dehydrogenase (NAD+) activity SubClassOf L-2-hydroxycarboxylate dehydrogenase (NAD+) activity

L-methionine cycle `http://purl.obolibrary.org/obo/GO_0033353`

Removed

L-methionine cycle definition “A cyclic series of interconversions involving S-adenosyl-L-homocysteine, L-homocysteine, L-methionine and S-adenosyl-L-methionine (SAM). Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of L-methionine.”
- database_cross_reference “PMID:31950558”
- database_cross_reference “PMID:39394448”

Added

L-methionine cycle term tracker item “https://github.com/geneontology/go-ontology/issues/32362”^^anyURI
L-methionine cycle definition “A cyclic series of interconversions involving S-adenosyl-L-homocysteine, L-homocysteine, L-methionine and S-adenosyl-L-methionine (SAM). Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of L-methionine.”
- database_cross_reference “PMID:32961717”
- database_cross_reference “PMID:31950558”
- database_cross_reference “PMID:39394448”
L-methionine cycle SubClassOf one-carbon metabolic process

L-phenylalaine oxidase activity `http://purl.obolibrary.org/obo/GO_0106329`

Removed

L-phenylalaine oxidase activity label “L-phenylalaine oxidase activity”

Added

L-phenylalaine oxidase activity label “L-phenylalanine oxidase activity”

N-acetylglucosamine biosynthetic process `http://purl.obolibrary.org/obo/GO_0006045`

Removed

N-acetylglucosamine biosynthetic process SubClassOf N-acetylglucosamine metabolic process

N-acetylglucosamine catabolic process `http://purl.obolibrary.org/obo/GO_0006046`

Removed

N-acetylglucosamine catabolic process SubClassOf N-acetylglucosamine metabolic process

N-acetylglucosamine metabolic process `http://purl.obolibrary.org/obo/GO_0006044`

Removed

N-acetylglucosamine metabolic process definition “The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein.”
- database_cross_reference “ISBN:0198506732”
N-acetylglucosamine metabolic process label “N-acetylglucosamine metabolic process”
N-acetylglucosamine metabolic process SubClassOf amino sugar metabolic process

Added

N-acetylglucosamine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/32273”^^anyURI
N-acetylglucosamine metabolic process consider N-acetylglucosamine biosynthetic process
N-acetylglucosamine metabolic process consider N-acetylglucosamine catabolic process
N-acetylglucosamine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein.”
- database_cross_reference “ISBN:0198506732”
N-acetylglucosamine metabolic process deprecated true
N-acetylglucosamine metabolic process comment “The reason for obsoletion is that this term was made in error and is an unnecessary grouping term.”
N-acetylglucosamine metabolic process label “obsolete N-acetylglucosamine metabolic process”

N-acetylmannosamine biosynthetic process `http://purl.obolibrary.org/obo/GO_0006052`

Removed

N-acetylmannosamine biosynthetic process SubClassOf N-acetylmannosamine metabolic process

N-acetylmannosamine catabolic process `http://purl.obolibrary.org/obo/GO_0006053`

Removed

N-acetylmannosamine catabolic process SubClassOf N-acetylmannosamine metabolic process

N-acetylmannosamine metabolic process `http://purl.obolibrary.org/obo/GO_0006051`

Removed

N-acetylmannosamine metabolic process definition “The chemical reactions and pathways involving N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose.”
- database_cross_reference “GOC:ai”
- database_cross_reference “ISBN:0198506732”
N-acetylmannosamine metabolic process label “N-acetylmannosamine metabolic process”
N-acetylmannosamine metabolic process SubClassOf amino sugar metabolic process

Added

N-acetylmannosamine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/32273”^^anyURI
N-acetylmannosamine metabolic process consider N-acetylmannosamine biosynthetic process
N-acetylmannosamine metabolic process consider N-acetylmannosamine catabolic process
N-acetylmannosamine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose.”
- database_cross_reference “GOC:ai”
- database_cross_reference “ISBN:0198506732”
N-acetylmannosamine metabolic process deprecated true
N-acetylmannosamine metabolic process comment “The reason for obsoletion is that this term was made in error and is an unnecessary grouping term.”
N-acetylmannosamine metabolic process label “obsolete N-acetylmannosamine metabolic process”

N-acetylneuraminate biosynthetic process `http://purl.obolibrary.org/obo/GO_0046380`

Removed

N-acetylneuraminate biosynthetic process SubClassOf N-acetylneuraminate metabolic process

N-acetylneuraminate catabolic process `http://purl.obolibrary.org/obo/GO_0019262`

Removed

N-acetylneuraminate catabolic process SubClassOf N-acetylneuraminate metabolic process

N-acetylneuraminate metabolic process `http://purl.obolibrary.org/obo/GO_0006054`

Removed

N-acetylneuraminate metabolic process definition “The chemical reactions and pathways involving N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid.”
- database_cross_reference “ISBN:0198506732”
N-acetylneuraminate metabolic process label “N-acetylneuraminate metabolic process”
N-acetylneuraminate metabolic process SubClassOf amino sugar metabolic process
N-acetylneuraminate metabolic process SubClassOf carboxylic acid metabolic process

Added

N-acetylneuraminate metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/32273”^^anyURI
N-acetylneuraminate metabolic process consider N-acetylneuraminate catabolic process
N-acetylneuraminate metabolic process consider N-acetylneuraminate biosynthetic process
N-acetylneuraminate metabolic process definition “OBSOLETE. The chemical reactions and pathways involving N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid.”
- database_cross_reference “ISBN:0198506732”
N-acetylneuraminate metabolic process deprecated true
N-acetylneuraminate metabolic process comment “The reason for obsoletion is that this term was made in error and is an unnecessary grouping term.”
N-acetylneuraminate metabolic process label “obsolete N-acetylneuraminate metabolic process”

NAD+ nucleosidase activity, cyclic ADP-ribose generating `http://purl.obolibrary.org/obo/GO_0061809`

Removed

Added

NAD+ nucleosidase activity, cyclic ADP-ribose generating term tracker item “https://github.com/geneontology/go-ontology/issues/32457”^^anyURI
NAD+ nucleosidase activity, cyclic ADP-ribose generating SubClassOf has part some obsolete cyclic ADP-ribose hydrolase

NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity `http://purl.obolibrary.org/obo/GO_0030701`

Removed

NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity database_cross_reference “EC:2.4.2.37”
NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity database_cross_reference “MetaCyc:2.4.2.37-RXN”
NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity database_cross_reference “RHEA:18077”
NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity exactMatch 2.4.2.37
NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity exactMatch 18077
NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity definition “Catalysis of the reaction: NAD+ + [dinitrogen reductase] = nicotinamide + ADP-D-ribosyl-[dinitrogen reductase].”
- database_cross_reference “EC:2.4.2.37”
NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity label “NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity”
NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity SubClassOf pentosyltransferase activity

Added

NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32501”^^anyURI
NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32503”^^anyURI
NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity term replaced by NAD+-protein-arginine ADP-ribosyltransferase activity
NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity definition “OBSOLETE. Catalysis of the reaction: L-arginyl-[dinitrogen reductase] + NAD+ = N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide + H+.”
- database_cross_reference “RHEA:18077”
NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity deprecated true
NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity comment “The reason for obsoletion is that this term represents a specific substrate of the parent GO:0106274 NAD+-protein-arginine ADP-ribosyltransferase activity.”
NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity label “obsolete NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity”

NAD+-protein-arginine ADP-ribosyltransferase activity `http://purl.obolibrary.org/obo/GO_0106274`

Added

NAD+-protein-arginine ADP-ribosyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32503”^^anyURI
NAD+-protein-arginine ADP-ribosyltransferase activity database_cross_reference “RHEA:18077”
NAD+-protein-arginine ADP-ribosyltransferase activity narrowMatch 18077

NAD-cap decapping `http://purl.obolibrary.org/obo/GO_0110155`

Removed

NAD-cap decapping definition “Cleavage of the 5’-NAD-cap of an RNA. The NAD-cap is present at the 5’-end of some RNAs in both bacetria and eukaryotes. While it promotes RNA stability in bacteria, it promotes RNA decay in eukaryotes.”
- database_cross_reference “PMID:31101919”
- database_cross_reference “PMID:28283058”
- database_cross_reference “PMID:25533955”
- database_cross_reference “GOC:sp”

Added

NAD-cap decapping definition “Cleavage of the 5’-NAD-cap of an RNA. The NAD-cap is present at the 5’-end of some RNAs in both bacteria and eukaryotes. While it promotes RNA stability in bacteria, it promotes RNA decay in eukaryotes.”
- database_cross_reference “PMID:31101919”
- database_cross_reference “PMID:28283058”
- database_cross_reference “PMID:25533955”
- database_cross_reference “GOC:sp”

NADH-dependent peroxiredoxin activity `http://purl.obolibrary.org/obo/GO_0102039`

Removed

NADH-dependent peroxiredoxin activity SubClassOf peroxiredoxin activity

Added

NADH-dependent peroxiredoxin activity term tracker item “https://github.com/geneontology/go-ontology/issues/32372”^^anyURI
NADH-dependent peroxiredoxin activity SubClassOf peroxidase activity

NAGS/NAGK complex `http://purl.obolibrary.org/obo/GO_0106098`

Removed

NAGS/NAGK complex definition “A protein complex that acts both as N-acetylglutamate synthase (NAGS) catalysing the production of N-Acetylglutamate from glutamate and acetyl-CoA, and as N-acetylglutamate kinase (NAGK) catalysing the reaction ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate.”
- database_cross_reference “GOC:lnp”
- database_cross_reference “PMID:11553611”

Added

NAGS/NAGK complex definition “A protein complex that acts both as N-acetylglutamate synthase (NAGS) catalyzing the production of N-Acetylglutamate from glutamate and acetyl-CoA, and as N-acetylglutamate kinase (NAGK) catalyzing the reaction ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate.”
- database_cross_reference “GOC:lnp”
- database_cross_reference “PMID:11553611”

NMDA glutamate receptor activity `http://purl.obolibrary.org/obo/GO_0004972`

Removed

NMDA glutamate receptor activity definition “A cation channel that opens in response to binding by extracellular glutmate, but only if glycine or D-serine is also bound and the membrane is depolarized. Voltage gating is indirect, due to ejection of bound magnesium from the pore at permissive voltages.”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:7790891”
- database_cross_reference “PMID:10049997”

Added

NMDA glutamate receptor activity definition “A cation channel that opens in response to binding by extracellular glutamate, but only if glycine or D-serine is also bound and the membrane is depolarized. Voltage gating is indirect, due to ejection of bound magnesium from the pore at permissive voltages.”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:7790891”
- database_cross_reference “PMID:10049997”

P-type cadmium transporter activity `http://purl.obolibrary.org/obo/GO_0008551`

Removed

P-type cadmium transporter activity database_cross_reference “RHEA:12132”
P-type cadmium transporter activity exactMatch 12132

Added

P-type cadmium transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/20824”^^anyURI
P-type cadmium transporter activity broadMatch 12132
P-type cadmium transporter activity comment “Note that RHEA:12132 represents both the ABC and the P-type cadmium transporters.”

R-loop processing `http://purl.obolibrary.org/obo/GO_0062176`

Removed

R-loop processing definition “A DNA metabolic process that results in the disassembly of R-loops. R-loops are three-stranded nucleic acid structures consisitng of an RNA:DNA heteroduplex and a looped-out non-template strand. Aberrant formation and persistence of R-loops block transcription elongation and cause DNA damage. Mechanisms that resolve R-loops are essential for genome stability.”
- database_cross_reference “PMID:27252122”
- database_cross_reference “PMID:33986538”
- database_cross_reference “PMID:28790157”

Added

R-loop processing definition “A DNA metabolic process that results in the disassembly of R-loops. R-loops are three-stranded nucleic acid structures consisting of an RNA:DNA heteroduplex and a looped-out non-template strand. Aberrant formation and persistence of R-loops block transcription elongation and cause DNA damage. Mechanisms that resolve R-loops are essential for genome stability.”
- database_cross_reference “PMID:27252122”
- database_cross_reference “PMID:33986538”
- database_cross_reference “PMID:28790157”

RADAR pathway `http://purl.obolibrary.org/obo/GO_0170074`

Added

RADAR pathway SubClassOf peroxisomal protein quality control

RNA (adenine-N6)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_7770107`

Added

Class: RNA (adenine-N6)-methyltransferase activity
RNA (adenine-N6)-methyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/27200”^^anyURI
RNA (adenine-N6)-methyltransferase activity created by “ai4c-agent”
RNA (adenine-N6)-methyltransferase activity creation date “2026-08-07T23:44:01Z”
RNA (adenine-N6)-methyltransferase activity has_exact_synonym “RNA (N6-adenosine)-methyltransferase activity”
RNA (adenine-N6)-methyltransferase activity has_exact_synonym “RNA m6A methyltransferase activity”
RNA (adenine-N6)-methyltransferase activity has_obo_namespace “molecular_function”
RNA (adenine-N6)-methyltransferase activity id “GO:7770107”
RNA (adenine-N6)-methyltransferase activity definition “Catalysis of the reaction: an adenosine in RNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in RNA + S-adenosyl-L-homocysteine + H+.”
- database_cross_reference “PMID:34023900”
- database_cross_reference “PMID:36736310”
RNA (adenine-N6)-methyltransferase activity label “RNA (adenine-N6)-methyltransferase activity”
RNA (adenine-N6)-methyltransferase activity SubClassOf N-methyltransferase activity
RNA (adenine-N6)-methyltransferase activity SubClassOf RNA methyltransferase activity

RQC-specific ribosome subunit dissociation `http://purl.obolibrary.org/obo/GO_7770113`

Added

Class: RQC-specific ribosome subunit dissociation
RQC-specific ribosome subunit dissociation term tracker item “https://github.com/geneontology/go-ontology/issues/32478”^^anyURI
RQC-specific ribosome subunit dissociation created by “ai4c-agent”
RQC-specific ribosome subunit dissociation creation date “2026-08-18T18:06:47Z”
RQC-specific ribosome subunit dissociation has_exact_synonym “ribosome disassembly involved in ribosome-associated quality control”
RQC-specific ribosome subunit dissociation has_narrow_synonym “ASCC-dependent ribosome subunit dissociation”
RQC-specific ribosome subunit dissociation has_narrow_synonym “RQT-dependent ribosome subunit dissociation”
RQC-specific ribosome subunit dissociation has_obo_namespace “biological_process”
RQC-specific ribosome subunit dissociation id “GO:7770113”
RQC-specific ribosome subunit dissociation definition “The disaggregation of a stalled ribosome into its constituent large and small ribosomal subunits as part of ribosome-associated quality control (RQC), releasing the large subunit with the incomplete nascent polypeptide chain still attached via peptidyl-tRNA for downstream RQC processing.”
- database_cross_reference “PMID:35452614”
- database_cross_reference “PMID:32203490”
- database_cross_reference “PMID:32579943”
RQC-specific ribosome subunit dissociation comment “In eukaryotes, this step is carried out by the yeast RQT complex (Rqt2/Slh1, Rqt3/Cue3, Rqt4) or the metazoan ASCC complex, acting on Hel2/ZNF598-ubiquitinated collided ribosomes. In bacteria, MutS2 splits stalled collided ribosomes; this term is not restricted to eukaryotes.”
RQC-specific ribosome subunit dissociation label “RQC-specific ribosome subunit dissociation”
RQC-specific ribosome subunit dissociation EquivalentTo ribosome disassembly and (part of some ribosome-associated quality control)
RQC-specific ribosome subunit dissociation SubClassOf ribosome disassembly
RQC-specific ribosome subunit dissociation SubClassOf part of some ribosome-associated quality control

RQC-trigger complex `http://purl.obolibrary.org/obo/GO_0180022`

Removed

RQC-trigger complex definition “A ribosome disassembly complex which dissociates stalled ribsome subunits as part of the ribosome quality control pathway. RQT complex is composed of a RNA helicase-family protein yeast Rqt2 (human ASCC3), a ubiquitin-binding protein yeast Rqt3, (human ASCC2), and Rqt4 (human TRIP4). The human complex has an additional component protein ASCC1 and can act as a transcriptional coactivator by interacting with transcription factors such as NF-kappa B.”
- database_cross_reference “PMID:12077347”
- database_cross_reference “PMID:32099016”
- database_cross_reference “PMID:28757607”

Added

RQC-trigger complex definition “A ribosome disassembly complex which dissociates stalled ribosome subunits as part of the ribosome quality control pathway. RQT complex is composed of a RNA helicase-family protein yeast Rqt2 (human ASCC3), a ubiquitin-binding protein yeast Rqt3, (human ASCC2), and Rqt4 (human TRIP4). The human complex has an additional component protein ASCC1 and can act as a transcriptional coactivator by interacting with transcription factors such as NF-kappa B.”
- database_cross_reference “PMID:12077347”
- database_cross_reference “PMID:32099016”
- database_cross_reference “PMID:28757607”

S-methylmethionine cycle `http://purl.obolibrary.org/obo/GO_0033528`

Removed

S-methylmethionine cycle definition “A cyclic series of interconversions involving S-methyl-L-methionine, S-adenosyl-L-homocysteine, S-adenosyl-L-methionine, L-homocysteine, and L-methionine. Converts the methionine group of adenosylmethionine back to free methionine, and may serve regulate the cellular adenosylmethionine level.”
- database_cross_reference “MetaCyc:PWY-5441”
- database_cross_reference “GOC:mah”

Added

S-methylmethionine cycle term tracker item “https://github.com/geneontology/go-ontology/issues/32362”^^anyURI
S-methylmethionine cycle definition “A cyclic series of interconversions involving S-methyl-L-methionine, S-adenosyl-L-homocysteine, S-adenosyl-L-methionine, L-homocysteine, and L-methionine. Converts the methionine group of S-adenosylmethionine back to free L-methionine, and may serve regulate the cellular adenosylmethionine level.”
- database_cross_reference “MetaCyc:PWY-5441”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:11337394”
S-methylmethionine cycle SubClassOf one-carbon metabolic process

Sca1 Ras guanyl-nucleotide exchange factor complex `http://purl.obolibrary.org/obo/GO_0170078`

Added

Class: Sca1 Ras guanyl-nucleotide exchange factor complex
Sca1 Ras guanyl-nucleotide exchange factor complex term tracker item “https://github.com/geneontology/go-ontology/issues/32432”^^anyURI
Sca1 Ras guanyl-nucleotide exchange factor complex created by “ew”
Sca1 Ras guanyl-nucleotide exchange factor complex creation date “2026-08-11T17:42:26Z”
Sca1 Ras guanyl-nucleotide exchange factor complex has_broad_synonym “Sca1 RasGEF complex”
Sca1 Ras guanyl-nucleotide exchange factor complex has_broad_synonym “Sca1 signaling complex”
Sca1 Ras guanyl-nucleotide exchange factor complex has_broad_synonym “Sca1-Aimless signaling complex”
Sca1 Ras guanyl-nucleotide exchange factor complex has_broad_synonym “Sca1-associated Ras guanyl-nucleotide exchange factor complex”
Sca1 Ras guanyl-nucleotide exchange factor complex has_obo_namespace “cellular_component”
Sca1 Ras guanyl-nucleotide exchange factor complex id “GO:0170078”
Sca1 Ras guanyl-nucleotide exchange factor complex definition “A protein complex found in Dictyostelium, containing the scaffold protein Sca1, the Ras guanine nucleotide exchange factors Aimless (RasGEFA) and RasGEFH, and PP2A components, which promotes RasC activation during chemotaxis.”
- database_cross_reference “PMID:20493808”
Sca1 Ras guanyl-nucleotide exchange factor complex label “Sca1 Ras guanyl-nucleotide exchange factor complex”
Sca1 Ras guanyl-nucleotide exchange factor complex SubClassOf Ras guanyl-nucleotide exchange factor complex

Sec body `http://purl.obolibrary.org/obo/GO_7770092`

Added

Class: Sec body
Sec body term tracker item “https://github.com/geneontology/go-ontology/issues/32313”^^anyURI
Sec body created by “ai4c-agent”
Sec body creation date “2026-07-28T23:40:49Z”
Sec body has_exact_synonym “sec-body”
Sec body has_obo_namespace “cellular_component”
Sec body id “GO:7770092”
Sec body definition “A condensate that forms reversibly in the cytoplasm under stress, notably amino acid starvation or salt stress, by coalescence of endoplasmic reticulum exit site (ERES) components including the scaffold protein Sec16 and COPII coat subunits. Sec bodies form through liquid-liquid phase separation and act as a protective reservoir for ERES components, permitting reversible shutdown of the early secretory pathway and promoting cell survival during stress.”
- database_cross_reference “PMID:25386913”
- database_cross_reference “PMID:36325988”
- database_cross_reference “PMID:31152627”
Sec body comment “A Sec body forms from components of an endoplasmic reticulum exit site (GO:0070971), which is progressively depleted as the Sec body grows; a Sec body is a distinct structure and is not part of an ER exit site.”
Sec body label “Sec body”
Sec body SubClassOf intracellular membraneless organelle
Sec body SubClassOf part of some cytoplasm

Sec body assembly `http://purl.obolibrary.org/obo/GO_7770093`

Added

Class: Sec body assembly
Sec body assembly term tracker item “https://github.com/geneontology/go-ontology/issues/32314”^^anyURI
Sec body assembly created by “ai4c-agent”
Sec body assembly creation date “2026-07-28T23:40:49Z”
Sec body assembly has_exact_synonym “Sec body formation”
Sec body assembly has_exact_synonym “sec-body assembly”
Sec body assembly has_obo_namespace “biological_process”
Sec body assembly id “GO:7770093”
Sec body assembly definition “The aggregation, arrangement and bonding together of a set of components to form a Sec body.”
- database_cross_reference “PMID:25386913”
- database_cross_reference “PMID:27874829”
Sec body assembly label “Sec body assembly”
Sec body assembly SubClassOf membraneless organelle assembly

T cell tolerance induction in mucosal-associated lymphoid tissue `http://purl.obolibrary.org/obo/GO_0002403`

Removed

T cell tolerance induction in mucosal-associated lymphoid tissue definition “Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by T cells.”
- database_cross_reference “ISBN:0781735149”
- database_cross_reference “PMID:16551263”
- database_cross_reference “GOC:jal”

Added

T cell tolerance induction in mucosal-associated lymphoid tissue term tracker item “https://github.com/geneontology/go-ontology/issues/20574”^^anyURI
T cell tolerance induction in mucosal-associated lymphoid tissue definition “Tolerance induction taking place in a T cell within the mucosal-associated lymphoid tissue (MALT).”
- database_cross_reference “ISBN:0781735149”
- database_cross_reference “PMID:16551263”
- database_cross_reference “GOC:jal”

T cell tolerance induction to tumor cell `http://purl.obolibrary.org/obo/GO_0002411`

Removed

T cell tolerance induction to tumor cell definition “A process of tolerance induction dependent on T cells which leads to immunological tolerance of a tumor.”
- database_cross_reference “PMID:16730260”
- database_cross_reference “ISBN:0781735149”
- database_cross_reference “GOC:add”

Added

T cell tolerance induction to tumor cell term tracker item “https://github.com/geneontology/go-ontology/issues/20574”^^anyURI
T cell tolerance induction to tumor cell definition “A process of tolerance induction taking place in a T cell which leads to immunological tolerance of a tumor.”
- database_cross_reference “PMID:16730260”
- database_cross_reference “ISBN:0781735149”
- database_cross_reference “GOC:add”

Tea1 cell-end complex `http://purl.obolibrary.org/obo/GO_0031500`

Removed

Tea1 cell-end complex definition “A high molecular weight complex characterized in S. pombe containing the cell-end anchoring protein Tea1. This complex is transported to the cell ends by microtubules and is involved in bipolar growth and the maintennce of normal cell polarity.”
- database_cross_reference “PMID:15936270”

Added

Tea1 cell-end complex definition “A high molecular weight complex characterized in S. pombe containing the cell-end anchoring protein Tea1. This complex is transported to the cell ends by microtubules and is involved in bipolar growth and the maintenance of normal cell polarity.”
- database_cross_reference “PMID:15936270”

Tim8-Tim13 complex `http://purl.obolibrary.org/obo/GO_7770104`

Added

Class: Tim8-Tim13 complex
Tim8-Tim13 complex term tracker item “https://github.com/geneontology/go-ontology/issues/32408”^^anyURI
Tim8-Tim13 complex created by “ai4c-agent”
Tim8-Tim13 complex creation date “2026-08-07T16:51:54Z”
Tim8-Tim13 complex has_exact_synonym “TIM8-13 complex”
Tim8-Tim13 complex has_obo_namespace “cellular_component”
Tim8-Tim13 complex id “GO:7770104”
Tim8-Tim13 complex definition “A chaperone complex located in the mitochondrial intermembrane space, composed of the small TIM proteins Tim8 and Tim13.”
- database_cross_reference “PMID:33355130”
- database_cross_reference “PMID:11101512”
Tim8-Tim13 complex label “Tim8-Tim13 complex”
Tim8-Tim13 complex SubClassOf mitochondrial intermembrane space chaperone complex

Tim9-Tim10 complex `http://purl.obolibrary.org/obo/GO_7770105`

Added

Class: Tim9-Tim10 complex
Tim9-Tim10 complex term tracker item “https://github.com/geneontology/go-ontology/issues/32408”^^anyURI
Tim9-Tim10 complex created by “ai4c-agent”
Tim9-Tim10 complex creation date “2026-08-07T16:51:54Z”
Tim9-Tim10 complex has_exact_synonym “TIM9-10 complex”
Tim9-Tim10 complex has_obo_namespace “cellular_component”
Tim9-Tim10 complex id “GO:7770105”
Tim9-Tim10 complex definition “A chaperone complex located in the mitochondrial intermembrane space, composed of the small TIM proteins Tim9 and Tim10.”
- database_cross_reference “PMID:16387659”
- database_cross_reference “PMID:33355130”
Tim9-Tim10 complex label “Tim9-Tim10 complex”
Tim9-Tim10 complex SubClassOf mitochondrial intermembrane space chaperone complex

U2 snRNA (adenine-N6)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0106348`

Added

U2 snRNA (adenine-N6)-methyltransferase activity SubClassOf RNA (adenine-N6)-methyltransferase activity

U6 snRNA (adenine(43)-N6)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0120048`

Added

U6 snRNA (adenine(43)-N6)-methyltransferase activity SubClassOf RNA (adenine-N6)-methyltransferase activity

UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity `http://purl.obolibrary.org/obo/GO_0051991`

Removed

UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity label “UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity”

Added

UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity label “UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminyltransferase activity”

UDP-N-acetylgalactosamine biosynthetic process `http://purl.obolibrary.org/obo/GO_0019277`

Removed

UDP-N-acetylgalactosamine biosynthetic process SubClassOf UDP-N-acetylgalactosamine metabolic process

UDP-N-acetylgalactosamine metabolic process `http://purl.obolibrary.org/obo/GO_0019276`

Removed

UDP-N-acetylgalactosamine metabolic process definition “The chemical reactions and pathways involving UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.”
- database_cross_reference “GOC:ai”
UDP-N-acetylgalactosamine metabolic process label “UDP-N-acetylgalactosamine metabolic process”
UDP-N-acetylgalactosamine metabolic process SubClassOf amino sugar metabolic process
UDP-N-acetylgalactosamine metabolic process SubClassOf nucleotide-sugar metabolic process

Added

UDP-N-acetylgalactosamine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/32273”^^anyURI
UDP-N-acetylgalactosamine metabolic process consider UDP-N-acetylgalactosamine biosynthetic process
UDP-N-acetylgalactosamine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.”
- database_cross_reference “GOC:ai”
UDP-N-acetylgalactosamine metabolic process deprecated true
UDP-N-acetylgalactosamine metabolic process comment “The reason for obsoletion is that this term was made in error and is an unnecessary grouping term.”
UDP-N-acetylgalactosamine metabolic process label “obsolete UDP-N-acetylgalactosamine metabolic process”

UDP-N-acetylglucosamine biosynthetic process `http://purl.obolibrary.org/obo/GO_0006048`

Removed

UDP-N-acetylglucosamine biosynthetic process SubClassOf UDP-N-acetylglucosamine metabolic process

UDP-N-acetylglucosamine metabolic process `http://purl.obolibrary.org/obo/GO_0006047`

Removed

UDP-N-acetylglucosamine metabolic process definition “The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.”
- database_cross_reference “GOC:ai”
UDP-N-acetylglucosamine metabolic process label “UDP-N-acetylglucosamine metabolic process”
UDP-N-acetylglucosamine metabolic process SubClassOf amino sugar metabolic process
UDP-N-acetylglucosamine metabolic process SubClassOf nucleotide-sugar metabolic process

Added

UDP-N-acetylglucosamine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/32273”^^anyURI
UDP-N-acetylglucosamine metabolic process consider UDP-N-acetylglucosamine biosynthetic process
UDP-N-acetylglucosamine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.”
- database_cross_reference “GOC:ai”
UDP-N-acetylglucosamine metabolic process deprecated true
UDP-N-acetylglucosamine metabolic process comment “The reason for obsoletion is that this term was made in error and is an unnecessary grouping term.”
UDP-N-acetylglucosamine metabolic process label “obsolete UDP-N-acetylglucosamine metabolic process”

acetyl-CoA C-myristoyltransferase activity `http://purl.obolibrary.org/obo/GO_0050633`

Removed

acetyl-CoA C-myristoyltransferase activity definition “Catalysis of the reaction: myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA.”
- database_cross_reference “MetaCyc:2.3.1.155-RXN”
- database_cross_reference “EC:2.3.1.155”

Added

acetyl-CoA C-myristoyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32501”^^anyURI
acetyl-CoA C-myristoyltransferase activity definition “Catalysis of the reaction: tetradecanoyl-CoA + acetyl-CoA = 3-oxohexadecanoyl-CoA + CoA.”
- database_cross_reference “RHEA:18161”
acetyl-CoA C-myristoyltransferase activity SubClassOf acetyl-CoA C-acyltransferase activity

alanyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0006419`

Removed

alanyl-tRNA aminoacylation definition “The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3’-OH group of an alanine accetping tRNA.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
alanyl-tRNA aminoacylation label “alanyl-tRNA aminoacylation”
alanyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for protein translation

Added

alanyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
alanyl-tRNA aminoacylation term replaced by tRNA aminoacylation for protein translation
alanyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3’-OH group of an alanine accetping tRNA.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
alanyl-tRNA aminoacylation deprecated true
alanyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004813 alanine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0006418 tRNA aminoacylation for protein translation.”
alanyl-tRNA aminoacylation label “obsolete alanyl-tRNA aminoacylation”

alcohol dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0004022`

Removed

alcohol dehydrogenase (NAD+) activity database_cross_reference “RHEA:12785”
alcohol dehydrogenase (NAD+) activity narrowMatch 12785

aldose reductase (NADPH) activity `http://purl.obolibrary.org/obo/GO_0004032`

Removed

aldose reductase (NADPH) activity has_exact_synonym “alditol:NADP+ 1-oxidoreductase activity”
aldose reductase (NADPH) activity broadMatch ALDEHYDE-REDUCTASE-RXN
aldose reductase (NADPH) activity broadMatch 1.1.1.21
aldose reductase (NADPH) activity exactMatch 12789
aldose reductase (NADPH) activity exactMatch R02820
aldose reductase (NADPH) activity definition “Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.”
- database_cross_reference “EC:1.1.1.21”
aldose reductase (NADPH) activity has_related_synonym “aldose reductase activity”
- database_cross_reference “EC:1.1.1.21”
aldose reductase (NADPH) activity label “aldose reductase (NADPH) activity”
aldose reductase (NADPH) activity SubClassOf alcohol dehydrogenase (NADP+) activity

Added

aldose reductase (NADPH) activity database_cross_reference “EC:1.1.1.21”
aldose reductase (NADPH) activity database_cross_reference “MetaCyc:ALDEHYDE-REDUCTASE-RXN”
aldose reductase (NADPH) activity database_cross_reference “RHEA:12785”
aldose reductase (NADPH) activity has_narrow_synonym “alditol:NADP+ 1-oxidoreductase activity”
aldose reductase (NADPH) activity has_narrow_synonym “aldose reductase (NADPH) activity”
aldose reductase (NADPH) activity exactMatch ALDEHYDE-REDUCTASE-RXN
aldose reductase (NADPH) activity exactMatch 1.1.1.21
aldose reductase (NADPH) activity narrowMatch 12785
aldose reductase (NADPH) activity narrowMatch 12789
aldose reductase (NADPH) activity narrowMatch R02820
aldose reductase (NADPH) activity definition “Catalysis of the reaction: an alditol + NAD(P)+ = an aldose + NAD(P)H + H+.”
- database_cross_reference “EC:1.1.1.21”
aldose reductase (NADPH) activity has_exact_synonym “alditol:NAD(P)+ 1-oxidoreductase activity”
- database_cross_reference “EC:1.1.1.21”
aldose reductase (NADPH) activity has_exact_synonym “aldose reductase activity”
- database_cross_reference “EC:1.1.1.21”
aldose reductase (NADPH) activity label “aldose reductase [NAD(P)H] activity”
aldose reductase (NADPH) activity SubClassOf alcohol dehydrogenase [NAD(P)+] activity

all-trans undecaprenol kinase activity `http://purl.obolibrary.org/obo/GO_0036432`

Removed

all-trans undecaprenol kinase activity database_cross_reference “RHEA:23752”
all-trans undecaprenol kinase activity exactMatch 23752
all-trans undecaprenol kinase activity definition “Catalysis of the reaction: ATP + undecaprenol + all-trans-undecaprenyl phosphate + ADP + H+.”
- database_cross_reference “RHEA:23752”
all-trans undecaprenol kinase activity label “all-trans undecaprenol kinase activity”
all-trans undecaprenol kinase activity SubClassOf undecaprenol kinase activity

Added

all-trans undecaprenol kinase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32370”^^anyURI
all-trans undecaprenol kinase activity term replaced by undecaprenol kinase activity
all-trans undecaprenol kinase activity definition “OBSOLETE. Catalysis of the reaction: ATP + undecaprenol + all-trans-undecaprenyl phosphate + ADP + H+.”
- database_cross_reference “RHEA:23752”
all-trans undecaprenol kinase activity deprecated true
all-trans undecaprenol kinase activity comment “This term was obsoleted because undecaprenol kinase (UdpK) has broad substrate specificity and phosphorylates both all-trans- and di-trans,poly-cis-undecaprenol (PMID:33310291), so a single grouping term (GO:0009038, undecaprenol kinase activity) is sufficient rather than splitting by isomer.”
all-trans undecaprenol kinase activity label “obsolete all-trans undecaprenol kinase activity”

amino acid activation `http://purl.obolibrary.org/obo/GO_0043038`

Removed

amino acid activation definition “The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule.”
- database_cross_reference “GOC:jl”
amino acid activation label “amino acid activation”
amino acid activation SubClassOf amino acid metabolic process

Added

amino acid activation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
amino acid activation consider tRNA aminoacylation
amino acid activation consider amino acid–[peptidyl-carrier protein] ligase activity
amino acid activation definition “OBSOLETE. The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule.”
- database_cross_reference “GOC:jl”
amino acid activation deprecated true
amino acid activation comment “The reason for obsoletion is that this term grouped two processes that do not share a common biology: tRNA aminoacylation (GO:0043039), in which the amino acid is esterified to a tRNA and is not itself metabolized, and nonribosomal amino acid activation (GO:0043041), in which the amino acid is covalently modified (adenylylated). Its placement under ‘amino acid metabolic process’ therefore caused tRNA aminoacylation and all of its descendants to be inferred as amino acid metabolism, which the GO editors rejected. Because no residual process is common to both children, the grouping term has been obsoleted rather than redefined. Consider GO:0043039 for tRNA charging and GO:7770118 for nonribosomal activation.”
amino acid activation label “obsolete amino acid activation”

amino acid activation for nonribosomal peptide biosynthetic process `http://purl.obolibrary.org/obo/GO_0043041`

Removed

amino acid activation for nonribosomal peptide biosynthetic process definition “Activation of an amino acid for incorporation into a peptide by a nonribosomal process.”
- database_cross_reference “GOC:jl”
amino acid activation for nonribosomal peptide biosynthetic process label “amino acid activation for nonribosomal peptide biosynthetic process”
amino acid activation for nonribosomal peptide biosynthetic process SubClassOf amino acid activation
amino acid activation for nonribosomal peptide biosynthetic process SubClassOf part of some nonribosomal peptide biosynthetic process

Added

amino acid activation for nonribosomal peptide biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
amino acid activation for nonribosomal peptide biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/30872”^^anyURI
amino acid activation for nonribosomal peptide biosynthetic process consider amino acid–[peptidyl-carrier protein] ligase activity
amino acid activation for nonribosomal peptide biosynthetic process definition “OBSOLETE. Activation of an amino acid for incorporation into a peptide by a nonribosomal process.”
- database_cross_reference “GOC:jl”
amino acid activation for nonribosomal peptide biosynthetic process deprecated true
amino acid activation for nonribosomal peptide biosynthetic process comment “The reason for obsoletion is that this term restates a single molecular function. Activation of an amino acid for nonribosomal incorporation is one catalysed reaction, adenylation of the amino acid followed by its transfer as a thioester onto the phosphopantetheine group of a carrier protein, and is fully covered by GO:7770118. Consider GO:7770118.”
amino acid activation for nonribosomal peptide biosynthetic process label “obsolete amino acid activation for nonribosomal peptide biosynthetic process”

amino acid adenylylation by nonribosomal peptide synthase `http://purl.obolibrary.org/obo/GO_0043042`

Removed

amino acid adenylylation by nonribosomal peptide synthase definition “Activation of an amino acid for incorporation into a peptide by a nonribosomal process, catalyzed by subunits of nonribosomal peptide synthase. The amino acid is adenylated at its carboxylate group (ATP-dependent) then transferred to the thiol group of an enzyme-bound phosphopantetheine cofactor.”
- database_cross_reference “PMID:9250661”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:9712910”
amino acid adenylylation by nonribosomal peptide synthase label “amino acid adenylylation by nonribosomal peptide synthase”
amino acid adenylylation by nonribosomal peptide synthase SubClassOf amino acid activation for nonribosomal peptide biosynthetic process

Added

amino acid adenylylation by nonribosomal peptide synthase term tracker item “https://github.com/geneontology/go-ontology/issues/30872”^^anyURI
amino acid adenylylation by nonribosomal peptide synthase consider amino acid–[peptidyl-carrier protein] ligase activity
amino acid adenylylation by nonribosomal peptide synthase definition “OBSOLETE. Activation of an amino acid for incorporation into a peptide by a nonribosomal process, catalyzed by subunits of nonribosomal peptide synthase. The amino acid is adenylated at its carboxylate group (ATP-dependent) then transferred to the thiol group of an enzyme-bound phosphopantetheine cofactor.”
- database_cross_reference “PMID:9250661”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:9712910”
amino acid adenylylation by nonribosomal peptide synthase deprecated true
amino acid adenylylation by nonribosomal peptide synthase comment “The reason for obsoletion is that this term restates a single molecular function, and names the same reaction as its former parent GO:0043041 with the gene product carrying it out. The reaction is fully covered by GO:7770118. Consider GO:7770118.”
amino acid adenylylation by nonribosomal peptide synthase label “obsolete amino acid adenylylation by nonribosomal peptide synthase”

amino acid–[peptidyl-carrier protein] ligase activity `http://purl.obolibrary.org/obo/GO_7770118`

Added

Class: amino acid–[peptidyl-carrier protein] ligase activity
amino acid–[peptidyl-carrier protein] ligase activity term tracker item “https://github.com/geneontology/go-ontology/issues/30872”^^anyURI
amino acid–[peptidyl-carrier protein] ligase activity created by “ai4c-agent”
amino acid–[peptidyl-carrier protein] ligase activity creation date “2026-09-03T23:34:51Z”
amino acid–[peptidyl-carrier protein] ligase activity database_cross_reference “RHEA:11656”
amino acid–[peptidyl-carrier protein] ligase activity database_cross_reference “RHEA:59436”
amino acid–[peptidyl-carrier protein] ligase activity database_cross_reference “RHEA:61680”
amino acid–[peptidyl-carrier protein] ligase activity database_cross_reference “RHEA:61688”
amino acid–[peptidyl-carrier protein] ligase activity database_cross_reference “RHEA:61696”
amino acid–[peptidyl-carrier protein] ligase activity database_cross_reference “RHEA:61704”
amino acid–[peptidyl-carrier protein] ligase activity database_cross_reference “RHEA:61788”
amino acid–[peptidyl-carrier protein] ligase activity database_cross_reference “RHEA:61800”
amino acid–[peptidyl-carrier protein] ligase activity database_cross_reference “RHEA:62452”
amino acid–[peptidyl-carrier protein] ligase activity database_cross_reference “RHEA:62492”
amino acid–[peptidyl-carrier protein] ligase activity has_obo_namespace “molecular_function”
amino acid–[peptidyl-carrier protein] ligase activity has_related_synonym “NRPS adenylation domain activity”
amino acid–[peptidyl-carrier protein] ligase activity has_related_synonym “amino acid adenylylation by nonribosomal peptide synthase”
amino acid–[peptidyl-carrier protein] ligase activity id “GO:7770118”
amino acid–[peptidyl-carrier protein] ligase activity narrowMatch 11656
amino acid–[peptidyl-carrier protein] ligase activity narrowMatch 59436
amino acid–[peptidyl-carrier protein] ligase activity narrowMatch 61680
amino acid–[peptidyl-carrier protein] ligase activity narrowMatch 61688
amino acid–[peptidyl-carrier protein] ligase activity narrowMatch 61696
amino acid–[peptidyl-carrier protein] ligase activity narrowMatch 61704
amino acid–[peptidyl-carrier protein] ligase activity narrowMatch 61788
amino acid–[peptidyl-carrier protein] ligase activity narrowMatch 61800
amino acid–[peptidyl-carrier protein] ligase activity narrowMatch 62452
amino acid–[peptidyl-carrier protein] ligase activity narrowMatch 62492
amino acid–[peptidyl-carrier protein] ligase activity definition “Catalysis of the ATP-dependent activation of an amino acid and its transfer as a thiol ester to the phosphopantetheine prosthetic group of a peptidyl-carrier protein, according to the reaction: an amino acid + ATP + holo-[peptidyl-carrier protein] = an aminoacyl-[peptidyl-carrier protein] + AMP + diphosphate. This is the reaction carried out by adenylation (A) domains of nonribosomal peptide synthetases, and by the standalone type II adenylation enzymes that load amino acids onto peptidyl-carrier proteins in related assembly lines.”
- database_cross_reference “PMID:9250661”
- database_cross_reference “PMID:17502372”
amino acid–[peptidyl-carrier protein] ligase activity label “amino acid–[peptidyl-carrier protein] ligase activity”
amino acid–[peptidyl-carrier protein] ligase activity SubClassOf acid-thiol ligase activity

ammonia assimilation cycle `http://purl.obolibrary.org/obo/GO_0019676`

Added

ammonia assimilation cycle term tracker item “https://github.com/geneontology/go-ontology/issues/32376”^^anyURI
ammonia assimilation cycle SubClassOf nutrient assimilation

antennal development `http://purl.obolibrary.org/obo/GO_0007469`

Removed

antennal development definition “The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli.”
- database_cross_reference “http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004526”

Added

antennal development term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
antennal development definition “The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli.”
- database_cross_reference “FBbt:00004511”

anterior compartment pattern formation `http://purl.obolibrary.org/obo/GO_0007387`

Removed

anterior compartment pattern formation definition “The process giving rise to specification of cell identity in the anterior compartments of the segmented embryo.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

anterior compartment pattern formation term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
anterior compartment pattern formation definition “The process giving rise to specification of cell identity in the anterior compartments of the segmented embryo.”
- database_cross_reference “ISBN:0879694238”

anterior region determination `http://purl.obolibrary.org/obo/GO_0007355`

Removed

anterior region determination definition “Specification of the anterior (head and thoracic segments) of the embryo by the gap genes; exemplified in insects by the actions of hunchback gene product.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

anterior region determination term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
anterior region determination definition “Specification of the anterior (head and thoracic segments) of the embryo by the gap genes; exemplified in insects by the actions of hunchback gene product.”
- database_cross_reference “ISBN:0879694238”

anterior/posterior axis specification, embryo `http://purl.obolibrary.org/obo/GO_0008595`

Removed

anterior/posterior axis specification, embryo definition “The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

anterior/posterior axis specification, embryo definition “The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote.”
- database_cross_reference “ISBN:0879694238”

antigen processing and presentation following phagocytosis `http://purl.obolibrary.org/obo/GO_0002747`

Added

antigen processing and presentation following phagocytosis term tracker item “https://github.com/geneontology/go-ontology/issues/32152”^^anyURI

arachidonate omega-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0052869`

Removed

arachidonate omega-hydroxylase activity database_cross_reference “KEGG_REACTION:R07041”
arachidonate omega-hydroxylase activity database_cross_reference “MetaCyc:RXN-19677”
arachidonate omega-hydroxylase activity database_cross_reference “RHEA:39755”
arachidonate omega-hydroxylase activity exactMatch 39755
arachidonate omega-hydroxylase activity definition “Catalysis of the reaction: (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH–hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH–hemoprotein reductase]. (5Z,8Z,11Z,14Z)-icosatetraenoic acid is also known as arachidonic acid is also and 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate as 20-HETE.”
- database_cross_reference “RHEA:39755”
arachidonate omega-hydroxylase activity has_exact_synonym “arachidonic acid:oxygen 1-oxidoreductase activity”
- has_synonym_type Systematic synonym
arachidonate omega-hydroxylase activity label “arachidonate omega-hydroxylase activity”
arachidonate omega-hydroxylase activity SubClassOf oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

Added

arachidonate omega-hydroxylase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32501”^^anyURI
arachidonate omega-hydroxylase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32503”^^anyURI
arachidonate omega-hydroxylase activity term replaced by long-chain fatty acid omega-hydroxylase activity
arachidonate omega-hydroxylase activity has_exact_synonym “arachidonic acid:oxygen 1-oxidoreductase activity”
arachidonate omega-hydroxylase activity definition “OBSOLETE. Catalysis of the reaction: (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH–hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH–hemoprotein reductase]. (5Z,8Z,11Z,14Z)-icosatetraenoic acid is also known as arachidonic acid is also and 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate as 20-HETE.”
- database_cross_reference “RHEA:39755”
arachidonate omega-hydroxylase activity deprecated true
arachidonate omega-hydroxylase activity comment “The reason for obsoletion is that this term represents a specific substrate of the parent term.”
arachidonate omega-hydroxylase activity label “obsolete arachidonate omega-hydroxylase activity”

arginyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0006420`

Removed

arginyl-tRNA aminoacylation definition “The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. The arginyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2’-OH group of an alanine accetping tRNA. The 2’-O-aminoacyl-tRNA will ultimately migrate to the 3’ position via transesterification.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
arginyl-tRNA aminoacylation label “arginyl-tRNA aminoacylation”
arginyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for protein translation

Added

arginyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
arginyl-tRNA aminoacylation term replaced by tRNA aminoacylation for protein translation
arginyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. The arginyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2’-OH group of an alanine accetping tRNA. The 2’-O-aminoacyl-tRNA will ultimately migrate to the 3’ position via transesterification.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
arginyl-tRNA aminoacylation deprecated true
arginyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004814 arginine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0006418 tRNA aminoacylation for protein translation.”
arginyl-tRNA aminoacylation label “obsolete arginyl-tRNA aminoacylation”

aryl hydrocarbon receptor binding `http://purl.obolibrary.org/obo/GO_0017162`

Removed

aryl hydrocarbon receptor binding definition “Binding to an aryl hydrocarbon receptor.”
- database_cross_reference “GOC:ai”
aryl hydrocarbon receptor binding label “aryl hydrocarbon receptor binding”
aryl hydrocarbon receptor binding SubClassOf signaling receptor binding
aryl hydrocarbon receptor binding SubClassOf RNA polymerase II-specific DNA-binding transcription factor binding

Added

aryl hydrocarbon receptor binding term tracker item “https://github.com/geneontology/go-ontology/issues/32477”^^anyURI
aryl hydrocarbon receptor binding consider RNA polymerase II-specific DNA-binding transcription factor binding
aryl hydrocarbon receptor binding definition “OBSOLETE. Binding to an aryl hydrocarbon receptor.”
- database_cross_reference “GOC:ai”
aryl hydrocarbon receptor binding deprecated true
aryl hydrocarbon receptor binding comment “The reason for obsoletion is that this term represents a gene product. Better captured with GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding, with aryl hydrocarbon receptor as ‘has_input’ in annotation extension.”
aryl hydrocarbon receptor binding label “obsolete aryl hydrocarbon receptor binding”

asparaginyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0006421`

Removed

asparaginyl-tRNA aminoacylation definition “The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. The asparaginyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3’-OH group of an asparagine-accetping tRNA.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
asparaginyl-tRNA aminoacylation label “asparaginyl-tRNA aminoacylation”
asparaginyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for protein translation

Added

asparaginyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
asparaginyl-tRNA aminoacylation term replaced by tRNA aminoacylation for protein translation
asparaginyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. The asparaginyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3’-OH group of an asparagine-accetping tRNA.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
asparaginyl-tRNA aminoacylation deprecated true
asparaginyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004816 asparagine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0006418 tRNA aminoacylation for protein translation.”
asparaginyl-tRNA aminoacylation label “obsolete asparaginyl-tRNA aminoacylation”

aspartyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0006422`

Removed

aspartyl-tRNA aminoacylation definition “The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. The aspartyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3’-OH group of an aspartic acid accetping tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “ISBN:0716730510”
aspartyl-tRNA aminoacylation label “aspartyl-tRNA aminoacylation”
aspartyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for protein translation

Added

aspartyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
aspartyl-tRNA aminoacylation term replaced by tRNA aminoacylation for protein translation
aspartyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. The aspartyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3’-OH group of an aspartic acid accetping tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “ISBN:0716730510”
aspartyl-tRNA aminoacylation deprecated true
aspartyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004815 aspartate-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0006418 tRNA aminoacylation for protein translation.”
aspartyl-tRNA aminoacylation label “obsolete aspartyl-tRNA aminoacylation”

assembly of large subunit precursor of preribosome `http://purl.obolibrary.org/obo/GO_1902626`

Removed

assembly of large subunit precursor of preribosome SubClassOf part of some ribosomal large subunit assembly

Added

assembly of large subunit precursor of preribosome term tracker item “https://github.com/geneontology/go-ontology/issues/32473”^^anyURI
assembly of large subunit precursor of preribosome SubClassOf part of some cytosolic large ribosomal subunit assembly

autophagy cargo adaptor activity `http://purl.obolibrary.org/obo/GO_0160247`

Removed

autophagy cargo adaptor activity SubClassOf part of some substrate localization to autophagosome

Added

autophagy cargo adaptor activity SubClassOf part of some macroautophagy

axonemal microtubule doublet inner sheath `http://purl.obolibrary.org/obo/GO_0160110`

Removed

axonemal microtubule doublet inner sheath definition “A structural network of microtubule inner proteins (MIPs) located inside the lumens of the A and B tubules of the axonemal microtuble doublet that helps stabilize the doublet microtubule.”
- database_cross_reference “GOC:krc”
- database_cross_reference “PMID:37295417”
- database_cross_reference “PMID:29430673”

Added

axonemal microtubule doublet inner sheath definition “A structural network of microtubule inner proteins (MIPs) located inside the lumens of the A and B tubules of the axonemal microtubule doublet that helps stabilize the doublet microtubule.”
- database_cross_reference “GOC:krc”
- database_cross_reference “PMID:37295417”
- database_cross_reference “PMID:29430673”

axonemal microtubule doublet ribbon `http://purl.obolibrary.org/obo/GO_0160115`

Removed

axonemal microtubule doublet ribbon definition “The 3 protofilaments A11, A12, and A13 of the A tubule along with associated inner sheath microtuble inner proteins (MIPs), either in the lumen of the A tubule or of the B tubule, which stabilize these three filiments within the axonemal doublet microtubule. The ribbon protofilaments separate the lumens of the A and B tubules.”
- database_cross_reference “PMID:1262413”
- database_cross_reference “GOC:krc”
- database_cross_reference “PMID:29430673”

Added

axonemal microtubule doublet ribbon definition “The 3 protofilaments A11, A12, and A13 of the A tubule along with associated inner sheath microtubule inner proteins (MIPs), either in the lumen of the A tubule or of the B tubule, which stabilize these three filaments within the axonemal doublet microtubule. The ribbon protofilaments separate the lumens of the A and B tubules.”
- database_cross_reference “PMID:1262413”
- database_cross_reference “GOC:krc”
- database_cross_reference “PMID:29430673”

bI3 intron splicing complex `http://purl.obolibrary.org/obo/GO_0106392`

Removed

bI3 intron splicing complex definition “Aprotein complex required for the splicing of intron 3 of the cytochrome b (COB) gene. In S. cerevisiae, the complex contains the maturase bI3 (which derives from one of the products of the splicing), the MRS1 cofactor and the intron 4 of the cytochrome b pre-mRNA. The two proteins stimulate the ribozyme activity of the pre-mRNA which autoctalyse a group I intron splicing.”
- database_cross_reference “GOC:lnp”
- database_cross_reference “PMID:11773622”

Added

bI3 intron splicing complex definition “A protein complex required for the splicing of intron 3 of the cytochrome b (COB) gene. In S. cerevisiae, the complex contains the maturase bI3 (which derives from one of the products of the splicing), the MRS1 cofactor and the intron 4 of the cytochrome b pre-mRNA. The two proteins stimulate the ribozyme activity of the pre-mRNA which autocatalyze a group I intron splicing.”
- database_cross_reference “GOC:lnp”
- database_cross_reference “PMID:11773622”

bI4 intron splicing complex `http://purl.obolibrary.org/obo/GO_0106391`

Removed

bI4 intron splicing complex definition “A protein complex required for the splicing of intron 4 of the cytochrome b (COB) gene. In S. cerevisiae, the complex contains the maturase bI4 (which derives from one of the products of the splicing), Leucyl-tRNA synthetase NAM2 and the intron 4 of the cytochrome b pre-mRNA. The two proteins stimulate the ribozyme activity of the pre-mRNA which autoctalyse a group I intron splicing.”
- database_cross_reference “PMID:19622748”
- database_cross_reference “GOC:lnp”

Added

bI4 intron splicing complex definition “A protein complex required for the splicing of intron 4 of the cytochrome b (COB) gene. In S. cerevisiae, the complex contains the maturase bI4 (which derives from one of the products of the splicing), Leucyl-tRNA synthetase NAM2 and the intron 4 of the cytochrome b pre-mRNA. The two proteins stimulate the ribozyme activity of the pre-mRNA which autocatalyze a group I intron splicing.”
- database_cross_reference “PMID:19622748”
- database_cross_reference “GOC:lnp”

binding `http://purl.obolibrary.org/obo/GO_0005488`

Added

binding term tracker item “https://github.com/geneontology/go-ontology/issues/32294”^^anyURI
binding in_subset gocheck_do_not_annotate

bioadhesive activity `http://purl.obolibrary.org/obo/GO_0140073`

Removed

bioadhesive activity definition “A structural molecule ativity that mediates an organism’s attachment to an environmental substrate via stable, non-selective binding by a protein to an external surface. Examples includes proteins used by insects to anchor pupae to surfaces.”
- database_cross_reference “PMID:39370426”

Added

bioadhesive activity definition “A structural molecule activity that mediates an organism’s attachment to an environmental substrate via stable, non-selective binding by a protein to an external surface. Examples includes proteins used by insects to anchor pupae to surfaces.”
- database_cross_reference “PMID:39370426”

bipolar cell growth `http://purl.obolibrary.org/obo/GO_0042815`

Removed

bipolar cell growth comment “Bipolar cell growth refers to a change in both cell size and cell shape. For shape changes where cell size is not affected, consider instead the term ‘establishment or maintenance of bipolar cell polarity resulting in cell shape ; GO:0061246’ and its children.”

Added

bipolar cell growth comment “Bipolar cell growth refers to a change in both cell size and cell shape. For shape changes where cell size is not affected, consider instead the term ‘establishment or maintenance of bipolar cell polarity; GO:0061245’ and its children.”

blastoderm segmentation `http://purl.obolibrary.org/obo/GO_0007350`

Removed

blastoderm segmentation definition “The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

blastoderm segmentation term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
blastoderm segmentation definition “The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo.”
- database_cross_reference “ISBN:0879694238”

canonical glycolysis `http://purl.obolibrary.org/obo/GO_0061621`

Removed

canonical glycolysis database_cross_reference “MetaCyc:ANAGLYCOLYSIS-PWY”
canonical glycolysis database_cross_reference “Wikipedia:Glycolysis”
canonical glycolysis definition “The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP.”
- database_cross_reference “GOC:dph”
- database_cross_reference “ISBN:0879010479”
- database_cross_reference “ISBN:0201090910”
canonical glycolysis label “canonical glycolysis”
canonical glycolysis SubClassOf glucose catabolic process
canonical glycolysis SubClassOf glycolytic process through glucose-6-phosphate
canonical glycolysis SubClassOf has part some glucokinase activity
canonical glycolysis SubClassOf has part some glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity

Added

canonical glycolysis term tracker item “https://github.com/geneontology/go-ontology/issues/32471”^^anyURI
canonical glycolysis term replaced by glycolytic process
canonical glycolysis definition “OBSOLETE. The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP.”
- database_cross_reference “GOC:dph”
- database_cross_reference “ISBN:0879010479”
- database_cross_reference “ISBN:0201090910”
canonical glycolysis deprecated true
canonical glycolysis comment “The reason for obsoletion is that this term represents a GO-CAM model.”
canonical glycolysis label “obsolete canonical glycolysis”

carbon catabolite activation of transcription from RNA polymerase II promoter `http://purl.obolibrary.org/obo/GO_0000436`

Removed

carbon catabolite activation of transcription from RNA polymerase II promoter definition “Any process involving carbon catabolites that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.”
- database_cross_reference “GOC:krc”
carbon catabolite activation of transcription from RNA polymerase II promoter label “carbon catabolite activation of transcription from RNA polymerase II promoter”
carbon catabolite activation of transcription from RNA polymerase II promoter SubClassOf carbon catabolite regulation of transcription from RNA polymerase II promoter
carbon catabolite activation of transcription from RNA polymerase II promoter SubClassOf positive regulation of transcription by RNA polymerase II
carbon catabolite activation of transcription from RNA polymerase II promoter SubClassOf carbon catabolite activation of transcription

Added

carbon catabolite activation of transcription from RNA polymerase II promoter term tracker item “https://github.com/geneontology/go-ontology/issues/21442”^^anyURI
carbon catabolite activation of transcription from RNA polymerase II promoter consider positive regulation of transcription by RNA polymerase II
carbon catabolite activation of transcription from RNA polymerase II promoter definition “OBSOLETE. Any process involving carbon catabolites that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.”
- database_cross_reference “GOC:krc”
carbon catabolite activation of transcription from RNA polymerase II promoter deprecated true
carbon catabolite activation of transcription from RNA polymerase II promoter comment “The reason for obsoletion is that these terms represent GO-CAM models.”
carbon catabolite activation of transcription from RNA polymerase II promoter label “obsolete carbon catabolite activation of transcription from RNA polymerase II promoter”

carbon catabolite regulation of transcription from RNA polymerase II promoter `http://purl.obolibrary.org/obo/GO_0000429`

Removed

carbon catabolite regulation of transcription from RNA polymerase II promoter definition “A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:krc”
carbon catabolite regulation of transcription from RNA polymerase II promoter label “carbon catabolite regulation of transcription from RNA polymerase II promoter”
carbon catabolite regulation of transcription from RNA polymerase II promoter SubClassOf regulation of transcription by RNA polymerase II
carbon catabolite regulation of transcription from RNA polymerase II promoter SubClassOf carbon catabolite regulation of transcription

Added

carbon catabolite regulation of transcription from RNA polymerase II promoter term tracker item “https://github.com/geneontology/go-ontology/issues/21442”^^anyURI
carbon catabolite regulation of transcription from RNA polymerase II promoter consider regulation of transcription by RNA polymerase II
carbon catabolite regulation of transcription from RNA polymerase II promoter definition “OBSOLETE. A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:krc”
carbon catabolite regulation of transcription from RNA polymerase II promoter deprecated true
carbon catabolite regulation of transcription from RNA polymerase II promoter comment “The reason for obsoletion is that these terms represent GO-CAM models.”
carbon catabolite regulation of transcription from RNA polymerase II promoter label “obsolete carbon catabolite regulation of transcription from RNA polymerase II promoter”

carboxylic acid biosynthetic process `http://purl.obolibrary.org/obo/GO_0046394`

Added

carboxylic acid biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/32294”^^anyURI
carboxylic acid biosynthetic process in_subset gocheck_do_not_annotate

carboxylic acid catabolic process `http://purl.obolibrary.org/obo/GO_0046395`

Added

carboxylic acid catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/32294”^^anyURI
carboxylic acid catabolic process in_subset gocheck_do_not_annotate

cellular response to interleukin-5 `http://purl.obolibrary.org/obo/GO_7770103`

Added

Class: cellular response to interleukin-5
cellular response to interleukin-5 term tracker item “https://github.com/geneontology/go-ontology/issues/32411”^^anyURI
cellular response to interleukin-5 created by “ai4c-agent”
cellular response to interleukin-5 creation date “2026-08-04T23:16:15Z”
cellular response to interleukin-5 has_exact_synonym “cellular response to IL-5”
cellular response to interleukin-5 has_obo_namespace “biological_process”
cellular response to interleukin-5 id “GO:7770103”
cellular response to interleukin-5 definition “Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-5 stimulus.”
- database_cross_reference “PMID:41207640”
cellular response to interleukin-5 label “cellular response to interleukin-5”
cellular response to interleukin-5 SubClassOf cellular response to cytokine stimulus
cellular response to interleukin-5 SubClassOf response to interleukin-5

chloroplast outer membrane translocon `http://purl.obolibrary.org/obo/GO_0010278`

Removed

chloroplast outer membrane translocon definition “The protein transport machinery of the chloroplast outer membrane that contains at least three components Toc159, Toc75 and Toc34, interacts with precursor proteins which are imported into the chloroplast in a GTP dependant manner.”
- database_cross_reference “PMID:11299338”

Added

chloroplast outer membrane translocon definition “The protein transport machinery of the chloroplast outer membrane that contains at least three components Toc159, Toc75 and Toc34, interacts with precursor proteins which are imported into the chloroplast in a GTP-dependent manner.”
- database_cross_reference “PMID:11299338”

chloroplast protein-transporting ATPase activity `http://purl.obolibrary.org/obo/GO_0016464`

Removed

chloroplast protein-transporting ATPase activity definition “Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the chloroplast stroma.”
- database_cross_reference “EC:7.4.2.4”

Added

chloroplast protein-transporting ATPase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32395”^^anyURI
chloroplast protein-transporting ATPase activity definition “Enables the transfer of a protein from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the chloroplast stroma.”
- database_cross_reference “EC:7.4.2.4”

citrate-malate shuttle `http://purl.obolibrary.org/obo/GO_7770108`

Added

Class: citrate-malate shuttle
citrate-malate shuttle term tracker item “https://github.com/geneontology/go-ontology/issues/32353”^^anyURI
citrate-malate shuttle created by “ai4c-agent”
citrate-malate shuttle creation date “2026-08-12T10:08:31Z”
citrate-malate shuttle database_cross_reference “Wikipedia:Citrate-malate_shuttle”
citrate-malate shuttle has_exact_synonym “citrate-malate cycle”
citrate-malate shuttle has_exact_synonym “malate-citrate shuttle”
citrate-malate shuttle has_narrow_synonym “acetyl-CoA biosynthesis from citrate”
citrate-malate shuttle has_obo_namespace “biological_process”
citrate-malate shuttle has_related_synonym “non-canonical TCA cycle”
citrate-malate shuttle id “GO:7770108”
citrate-malate shuttle definition “The process of transferring acetyl-CoA from the mitochondrion to the cytosol via citrate. Acetyl-CoA and oxaloacetate produced in the mitochondrion are condensed to citrate by citrate synthase; the citrate is exported to the cytosol by the mitochondrial citrate/malate antiporter in exchange for malate; in the cytosol, ATP citrate lyase cleaves the citrate back to acetyl-CoA and oxaloacetate; the oxaloacetate is then reduced to malate by cytosolic malate dehydrogenase, and the malate is imported back into the mitochondrion to complete the cycle.”
- database_cross_reference “PMID:32414018”
- database_cross_reference “PMID:35264789”
citrate-malate shuttle label “citrate-malate shuttle”
citrate-malate shuttle EquivalentTo metabolic process and (has part some ATP citrate synthase activity) and (has part some L-malate dehydrogenase (NAD+) activity)
citrate-malate shuttle SubClassOf acetyl-CoA metabolic process
citrate-malate shuttle SubClassOf citrate metabolic process
citrate-malate shuttle SubClassOf has part some ATP citrate synthase activity
citrate-malate shuttle SubClassOf has part some mitochondrial citrate transmembrane transport
citrate-malate shuttle SubClassOf has part some L-malate dehydrogenase (NAD+) activity

citrate:2-oxoglutarate antiporter activity `http://purl.obolibrary.org/obo/GO_0180056`

Removed

citrate:2-oxoglutarate antiporter activity definition “Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + 2-oxogluarate(in) = citrate(in) + 2-oxogluarat(out).”
- database_cross_reference “PMID:20371607”

Added

citrate:2-oxoglutarate antiporter activity definition “Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + 2-oxoglutarate(in) = citrate(in) + 2-oxoglutarate(out).”
- database_cross_reference “PMID:20371607”

clathrin coat assembly involved in endocytosis `http://purl.obolibrary.org/obo/GO_0099049`

Removed

clathrin coat assembly involved in endocytosis definition “The process that results in the assembly of clathrin triskelia into a clathrin cage during endocytosis. Clathrin is recruited to the plasma membrane via interaction with scaffolding proteins that bridge between clathtin and cell surface receptors. Clathrin coat formation is concomittant with coated pit formation leading to endocytic vesicle formation.”
- database_cross_reference “PMID:21779028”

Added

clathrin coat assembly involved in endocytosis definition “The process that results in the assembly of clathrin triskelia into a clathrin cage during endocytosis. Clathrin is recruited to the plasma membrane via interaction with scaffolding proteins that bridge between clathrin and cell surface receptors. Clathrin coat formation is concomitant with coated pit formation leading to endocytic vesicle formation.”
- database_cross_reference “PMID:21779028”

cochlear hair cell ribbon synapse `http://purl.obolibrary.org/obo/GO_0098683`

Removed

cochlear hair cell ribbon synapse definition “A ribbon synpase of an auditory hair cell of the cochlear. These ribbon synapses contain spherical synaptic ribbons and lack and arciform density.”
- database_cross_reference “PMID:15626493”

Added

cochlear hair cell ribbon synapse definition “A ribbon synapse of an auditory hair cell of the cochlear. These ribbon synapses contain spherical synaptic ribbons and lack arciform density.”
- database_cross_reference “PMID:15626493”

coenzyme A phosphatase activity `http://purl.obolibrary.org/obo/GO_0140477`

Added

Class: coenzyme A phosphatase activity
coenzyme A phosphatase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32572”^^anyURI
coenzyme A phosphatase activity created by “pg”
coenzyme A phosphatase activity creation date “2026-09-08T11:43:30Z”
coenzyme A phosphatase activity has_obo_namespace “molecular_function”
coenzyme A phosphatase activity id “GO:0140477”
coenzyme A phosphatase activity definition “Catalysis of the reaction: CoA + H2O = 3’-dephospho-CoA + phosphate.”
- database_cross_reference “PMID:42033660”
coenzyme A phosphatase activity label “coenzyme A phosphatase activity”
coenzyme A phosphatase activity SubClassOf phosphatase activity

compartment pattern specification `http://purl.obolibrary.org/obo/GO_0007386`

Removed

compartment pattern specification definition “The regionalization process in which embryonic segments are divided into compartments that will result in differences in cell differentiation.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

compartment pattern specification term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
compartment pattern specification definition “The regionalization process in which embryonic segments are divided into compartments that will result in differences in cell differentiation.”
- database_cross_reference “ISBN:0879694238”

corticotrophin-releasing factor receptor activity `http://purl.obolibrary.org/obo/GO_0015056`

Removed

corticotrophin-releasing factor receptor activity definition “Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity.”
- database_cross_reference “PMID:12032352”
corticotrophin-releasing factor receptor activity label “corticotrophin-releasing factor receptor activity”

Added

corticotrophin-releasing factor receptor activity definition “Combining with the corticotropin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity.”
- database_cross_reference “PMID:12032352”
corticotrophin-releasing factor receptor activity label “corticotropin-releasing factor receptor activity”

corticotropin-releasing hormone receptor activity `http://purl.obolibrary.org/obo/GO_0043404`

Removed

corticotropin-releasing hormone receptor activity has_exact_synonym “corticotropin-releasing factor receptor activity”
- database_cross_reference “GOC:bf”

Added

corticotropin-releasing hormone receptor activity has_exact_synonym “corticotropin releasing factor receptor activity”
- database_cross_reference “GOC:bf”

creatine metabolic process `http://purl.obolibrary.org/obo/GO_0006600`

Added

creatine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/32279”^^anyURI

cysteinyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0006423`

Removed

cysteinyl-tRNA aminoacylation definition “The process of coupling L-cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2’-OH group of a cysteine-accepting tRNA. The 2’-O-aminoacyl-tRNA will ultimately migrate to the 3’ position via transesterification.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
cysteinyl-tRNA aminoacylation label “cysteinyl-tRNA aminoacylation”
cysteinyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for protein translation

Added

cysteinyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
cysteinyl-tRNA aminoacylation term replaced by tRNA aminoacylation for protein translation
cysteinyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling L-cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2’-OH group of a cysteine-accepting tRNA. The 2’-O-aminoacyl-tRNA will ultimately migrate to the 3’ position via transesterification.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
cysteinyl-tRNA aminoacylation deprecated true
cysteinyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004817 cysteine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0006418 tRNA aminoacylation for protein translation.”
cysteinyl-tRNA aminoacylation label “obsolete cysteinyl-tRNA aminoacylation”

cytoplasm protein quality control `http://purl.obolibrary.org/obo/GO_0140455`

Removed

cytoplasm protein quality control definition “The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are either targeted to cytoplasmic proteasomes for degradation or protected by chaperones to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding.”
- database_cross_reference “PMID:32075773”

Added

cytoplasm protein quality control term tracker item “https://github.com/geneontology/go-ontology/issues/32274”^^anyURI
cytoplasm protein quality control term tracker item “https://github.com/geneontology/go-ontology/issues/32442”^^anyURI
cytoplasm protein quality control definition “The chemical reactions and pathways resulting in the breakdown or refolding of aberrant proteins in the cytoplasm, including misfolded proteins and orphan subunits that fail to assemble into their cognate protein complex, in which the substrates are either targeted to cytoplasmic proteasomes for degradation or protected by chaperones to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding.”
- database_cross_reference “PMID:35316660”
- database_cross_reference “PMID:30075143”
- database_cross_reference “PMID:32075773”

cytoplasmic alanyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_1990762`

Removed

cytoplasmic alanyl-tRNA aminoacylation definition “The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase involved in cytoplasmic translation.”
- database_cross_reference “GOC:vw”
cytoplasmic alanyl-tRNA aminoacylation label “cytoplasmic alanyl-tRNA aminoacylation”
cytoplasmic alanyl-tRNA aminoacylation SubClassOf alanyl-tRNA aminoacylation
cytoplasmic alanyl-tRNA aminoacylation SubClassOf part of some cytoplasmic translation

Added

cytoplasmic alanyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
cytoplasmic alanyl-tRNA aminoacylation term replaced by tRNA aminoacylation for protein translation
cytoplasmic alanyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase involved in cytoplasmic translation.”
- database_cross_reference “GOC:vw”
cytoplasmic alanyl-tRNA aminoacylation deprecated true
cytoplasmic alanyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004813 alanine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0006418 tRNA aminoacylation for protein translation.”
cytoplasmic alanyl-tRNA aminoacylation label “obsolete cytoplasmic alanyl-tRNA aminoacylation”

cytosol to ERGIC protein transport `http://purl.obolibrary.org/obo/GO_0106273`

Removed

cytosol to ERGIC protein transport definition “The directed movement of proteins from the cystosol to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC).”
- database_cross_reference “PMID:32272059”

Added

cytosol to ERGIC protein transport definition “The directed movement of proteins from the cytosol to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC).”
- database_cross_reference “PMID:32272059”

cytosolic valyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0061475`

Removed

cytosolic valyl-tRNA aminoacylation definition “The process of coupling valine to valyl-tRNA in the cytosol, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:dph”
cytosolic valyl-tRNA aminoacylation label “cytosolic valyl-tRNA aminoacylation”
cytosolic valyl-tRNA aminoacylation EquivalentTo valyl-tRNA aminoacylation and (occurs in some cytosol)
cytosolic valyl-tRNA aminoacylation SubClassOf valyl-tRNA aminoacylation
cytosolic valyl-tRNA aminoacylation SubClassOf occurs in some cytosol

Added

cytosolic valyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
cytosolic valyl-tRNA aminoacylation term replaced by tRNA aminoacylation for protein translation
cytosolic valyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling valine to valyl-tRNA in the cytosol, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:dph”
cytosolic valyl-tRNA aminoacylation deprecated true
cytosolic valyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004832 valine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0006418 tRNA aminoacylation for protein translation.”
cytosolic valyl-tRNA aminoacylation label “obsolete cytosolic valyl-tRNA aminoacylation”

dendritic cell cytokine production `http://purl.obolibrary.org/obo/GO_0002371`

Removed

dendritic cell cytokine production comment “Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the ‘regulation’ children terms.”

Added

dendritic cell cytokine production term tracker item “https://github.com/geneontology/go-ontology/issues/20574”^^anyURI
dendritic cell cytokine production comment “Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the ‘regulation’ children terms. The is_a link to GO:0002443 is asserted rather than inferred because GO:0002443 has no logical definition; it must be maintained by hand (see #20574).”

dermatan sulfate proteoglycan biosynthetic process `http://purl.obolibrary.org/obo/GO_0050651`

Removed

dermatan sulfate proteoglycan biosynthetic process definition “The chemical reactions and pathways resulting in the formation of dermatan sulfate proteoglycans, which consist of a core protein linked to a dermatan sulfate glycosaminoglycan. The dermatan sulfate chain is composed of the repeating disaccharide unit beta-(1,4)-D-hexuronic acid-beta-(1,3)-N-acetyl-D-galactosamine. Tthe former can be a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter can be O-sulfated. Dermatan sulfate chains are covalently linked to serine/threonine residues (O-linked) of the core protein via a tetrasaccharide linker sequence (xylose-galactose-galactose-glucuronate).”
- database_cross_reference “PMID:17239763”

Added

dermatan sulfate proteoglycan biosynthetic process definition “The chemical reactions and pathways resulting in the formation of dermatan sulfate proteoglycans, which consist of a core protein linked to a dermatan sulfate glycosaminoglycan. The dermatan sulfate chain is composed of the repeating disaccharide unit beta-(1,4)-D-hexuronic acid-beta-(1,3)-N-acetyl-D-galactosamine. The former can be a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter can be O-sulfated. Dermatan sulfate chains are covalently linked to serine/threonine residues (O-linked) of the core protein via a tetrasaccharide linker sequence (xylose-galactose-galactose-glucuronate).”
- database_cross_reference “PMID:17239763”

detection of endoplasmic reticulum overloading `http://purl.obolibrary.org/obo/GO_0002234`

Removed

detection of endoplasmic reticulum overloading definition “The series of events in which a stimulus generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum is received and converted into a molecular signal.”
- database_cross_reference “PMID:10390516”
- database_cross_reference “GOC:add”
detection of endoplasmic reticulum overloading label “detection of endoplasmic reticulum overloading”
detection of endoplasmic reticulum overloading SubClassOf ER overload response
detection of endoplasmic reticulum overloading SubClassOf detection of biotic stimulus

Added

detection of endoplasmic reticulum overloading term tracker item “https://github.com/geneontology/go-ontology/issues/32516”^^anyURI
detection of endoplasmic reticulum overloading definition “OBSOLETE. The series of events in which a stimulus generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum is received and converted into a molecular signal.”
- database_cross_reference “PMID:10390516”
- database_cross_reference “GOC:add”
detection of endoplasmic reticulum overloading deprecated true
detection of endoplasmic reticulum overloading comment “The reason for obsoletion is that the term was made in error and describes a molecular function.”
detection of endoplasmic reticulum overloading label “obsolete detection of endoplasmic reticulum overloading”

determination of genital disc primordium `http://purl.obolibrary.org/obo/GO_0035225`

Removed

determination of genital disc primordium definition “Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two.”
- database_cross_reference “PMID:11494318”
- database_cross_reference “GOC:bf”

Added

determination of genital disc primordium definition “Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primordium located anteriorly, the anal primordium located posteriorly, and the male genital primordium between the two.”
- database_cross_reference “PMID:11494318”
- database_cross_reference “GOC:bf”

di-trans, poly-cis-undecaprenol kinase activity `http://purl.obolibrary.org/obo/GO_0036433`

Removed

di-trans, poly-cis-undecaprenol kinase activity database_cross_reference “EC:2.7.1.66”
di-trans, poly-cis-undecaprenol kinase activity database_cross_reference “KEGG_REACTION:R05626”
di-trans, poly-cis-undecaprenol kinase activity database_cross_reference “MetaCyc:UNDECAPRENOL-KINASE-RXN”
di-trans, poly-cis-undecaprenol kinase activity database_cross_reference “RHEA:28122”
di-trans, poly-cis-undecaprenol kinase activity has_related_synonym “ditrans,polycis-undecaprenol kinase activity”
di-trans, poly-cis-undecaprenol kinase activity exactMatch UNDECAPRENOL-KINASE-RXN
di-trans, poly-cis-undecaprenol kinase activity exactMatch 2.7.1.66
di-trans, poly-cis-undecaprenol kinase activity exactMatch 28122
di-trans, poly-cis-undecaprenol kinase activity exactMatch R05626
di-trans, poly-cis-undecaprenol kinase activity definition “Catalysis of the reaction: di-trans, octa-cis-undecaprenol + ATP = di-trans,octa-cis-undecaprenyl phosphate + ADP + H+.”
- database_cross_reference “RHEA:28122”
di-trans, poly-cis-undecaprenol kinase activity label “di-trans, poly-cis-undecaprenol kinase activity”
di-trans, poly-cis-undecaprenol kinase activity SubClassOf undecaprenol kinase activity

Added

di-trans, poly-cis-undecaprenol kinase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32370”^^anyURI
di-trans, poly-cis-undecaprenol kinase activity term replaced by undecaprenol kinase activity
di-trans, poly-cis-undecaprenol kinase activity definition “OBSOLETE. Catalysis of the reaction: di-trans, octa-cis-undecaprenol + ATP = di-trans,octa-cis-undecaprenyl phosphate + ADP + H+.”
- database_cross_reference “RHEA:28122”
di-trans, poly-cis-undecaprenol kinase activity deprecated true
di-trans, poly-cis-undecaprenol kinase activity comment “This term was obsoleted because undecaprenol kinase (UdpK) has broad substrate specificity and phosphorylates both all-trans- and di-trans,poly-cis-undecaprenol (PMID:33310291), so a single grouping term (GO:0009038, undecaprenol kinase activity) is sufficient rather than splitting by isomer.”
di-trans, poly-cis-undecaprenol kinase activity label “obsolete di-trans, poly-cis-undecaprenol kinase activity”

dihydrolipoyl dehydrogenase (NADH) activity `http://purl.obolibrary.org/obo/GO_0004148`

Added

dihydrolipoyl dehydrogenase (NADH) activity term tracker item “https://github.com/geneontology/go-ontology/issues/32557”^^anyURI
dihydrolipoyl dehydrogenase (NADH) activity broadMatch 30795

dihydrolipoyllysine-residue glutaryltransferase activity `http://purl.obolibrary.org/obo/GO_0120571`

Added

dihydrolipoyllysine-residue glutaryltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32557”^^anyURI
dihydrolipoyllysine-residue glutaryltransferase activity broadMatch 30795
dihydrolipoyllysine-residue glutaryltransferase activity exactMatch 86675

dinoflagellate peduncle `http://purl.obolibrary.org/obo/GO_1990905`

Removed

dinoflagellate peduncle definition “A small, flexible, finger-like projection of cytoplasm containing an array of microtubles and located near the flagellar pores in some photosynthetic as well as nonphotosynthetic dinoflagellate species. Its functions are not fully understood, but it has been associated with feeding behavior (phagotrophy).”
- database_cross_reference “Wikipedia:Dinoflagellate”
- database_cross_reference “PMID:1480107”
- database_cross_reference “GOC:at”

Added

dinoflagellate peduncle definition “A small, flexible, finger-like projection of cytoplasm containing an array of microtubules and located near the flagellar pores in some photosynthetic as well as nonphotosynthetic dinoflagellate species. Its functions are not fully understood, but it has been associated with feeding behavior (phagotrophy).”
- database_cross_reference “Wikipedia:Dinoflagellate”
- database_cross_reference “PMID:1480107”
- database_cross_reference “GOC:at”

dissimilatory sulfate reduction `http://purl.obolibrary.org/obo/GO_0019420`

Removed

dissimilatory sulfate reduction SubClassOf sulfate assimilation

Added

dissimilatory sulfate reduction SubClassOf sulfur compound metabolic process

endoplasmic reticulum protein quality control `http://purl.obolibrary.org/obo/GO_0170080`

Added

Class: endoplasmic reticulum protein quality control
endoplasmic reticulum protein quality control term tracker item “https://github.com/geneontology/go-ontology/issues/32495”^^anyURI
endoplasmic reticulum protein quality control created by “ew”
endoplasmic reticulum protein quality control creation date “2026-08-20T16:01:05Z”
endoplasmic reticulum protein quality control has_obo_namespace “biological_process”
endoplasmic reticulum protein quality control has_related_synonym “ERQC”
endoplasmic reticulum protein quality control id “GO:0170080”
endoplasmic reticulum protein quality control definition “Any process that monitors and mediates the fidelity of protein folding in the endoplasmic reticulum, or prevents misfolded proteins from accumulating in or transiting the endoplasmic reticulum. Processes result in the export of correctly folded proteins to the Golgi apparatus while retaining, refolding, or targeting terminally misfolded proteins for degradation.”
- database_cross_reference “PMID:12612637”
- database_cross_reference “PMID:17129784”
endoplasmic reticulum protein quality control label “endoplasmic reticulum protein quality control”
endoplasmic reticulum protein quality control SubClassOf protein quality control for misfolded or incompletely synthesized proteins

endoplasmic reticulum stress-induced pre-emptive quality control `http://purl.obolibrary.org/obo/GO_0061857`

Removed

endoplasmic reticulum stress-induced pre-emptive quality control has_exact_synonym “ER stress-indiced pre-emptive quality control”
endoplasmic reticulum stress-induced pre-emptive quality control definition “The response to endoplasimic reticulum stress in which nascent proteins are degraded by attenuation of their translocation into the ER followed by rerouting to the cytosol without cleavage of the signal peptide, and subsequent degradation by the proteasome.”
- database_cross_reference “PMID:17129784”
- database_cross_reference “PMID:26565908”

Added

endoplasmic reticulum stress-induced pre-emptive quality control term tracker item “https://github.com/geneontology/go-ontology/issues/20914”^^anyURI
endoplasmic reticulum stress-induced pre-emptive quality control has_exact_synonym “ER stress-induced pre-emptive quality control”
endoplasmic reticulum stress-induced pre-emptive quality control definition “The response to endoplasmic reticulum stress in which nascent proteins are degraded by attenuation of their translocation into the ER followed by rerouting to the cytosol without cleavage of the signal peptide, and subsequent degradation by the proteasome.”
- database_cross_reference “PMID:17129784”
- database_cross_reference “PMID:26565908”
endoplasmic reticulum stress-induced pre-emptive quality control SubClassOf endoplasmic reticulum protein quality control

endoplasmic reticulum unfolded protein response `http://purl.obolibrary.org/obo/GO_0030968`

Added

endoplasmic reticulum unfolded protein response term tracker item “https://github.com/geneontology/go-ontology/issues/20914”^^anyURI
endoplasmic reticulum unfolded protein response SubClassOf part of some endoplasmic reticulum protein quality control

ent-kaurene biosynthetic process `http://purl.obolibrary.org/obo/GO_0033332`

Removed

ent-kaurene biosynthetic process SubClassOf ent-kaurene metabolic process

ent-kaurene metabolic process `http://purl.obolibrary.org/obo/GO_0033331`

Removed

ent-kaurene metabolic process definition “The chemical reactions and pathways involving ent-kaur-16-ene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins.”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:17064690”
ent-kaurene metabolic process label “ent-kaurene metabolic process”
ent-kaurene metabolic process SubClassOf terpene metabolic process

Added

ent-kaurene metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/28120”^^anyURI
ent-kaurene metabolic process consider ent-kaurene biosynthetic process
ent-kaurene metabolic process definition “OBSOLETE. The chemical reactions and pathways involving ent-kaur-16-ene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins.”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:17064690”
ent-kaurene metabolic process deprecated true
ent-kaurene metabolic process comment “The reason for obsoletion is that this term was an unnecessary grouping term.”
ent-kaurene metabolic process label “obsolete ent-kaurene metabolic process”

establishment or maintenance of bipolar cell polarity regulating cell shape `http://purl.obolibrary.org/obo/GO_0061246`

Removed

establishment or maintenance of bipolar cell polarity regulating cell shape definition “Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns that regulates the shaping of a cell.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:vw”
establishment or maintenance of bipolar cell polarity regulating cell shape label “establishment or maintenance of bipolar cell polarity regulating cell shape”
establishment or maintenance of bipolar cell polarity regulating cell shape SubClassOf establishment or maintenance of bipolar cell polarity
establishment or maintenance of bipolar cell polarity regulating cell shape SubClassOf establishment or maintenance of cell polarity regulating cell shape

Added

establishment or maintenance of bipolar cell polarity regulating cell shape term tracker item “https://github.com/geneontology/go-ontology/issues/21217”^^anyURI
establishment or maintenance of bipolar cell polarity regulating cell shape term replaced by establishment or maintenance of bipolar cell polarity
establishment or maintenance of bipolar cell polarity regulating cell shape definition “OBSOLETE. Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns that regulates the shaping of a cell.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:vw”
establishment or maintenance of bipolar cell polarity regulating cell shape deprecated true
establishment or maintenance of bipolar cell polarity regulating cell shape comment “The reason for obsoletion is that this term was made in error.”
establishment or maintenance of bipolar cell polarity regulating cell shape label “obsolete establishment or maintenance of bipolar cell polarity regulating cell shape”

exit from cytosolic ribosome hibernation `http://purl.obolibrary.org/obo/GO_7770110`

Added

Class: exit from cytosolic ribosome hibernation
exit from cytosolic ribosome hibernation term tracker item “https://github.com/geneontology/go-ontology/issues/32461”^^anyURI
exit from cytosolic ribosome hibernation created by “ai4c-agent”
exit from cytosolic ribosome hibernation creation date “2026-08-14T22:52:06Z”
exit from cytosolic ribosome hibernation has_exact_synonym “ribosome hibernation exit”
exit from cytosolic ribosome hibernation has_exact_synonym “translational restart after ribosome hibernation”
exit from cytosolic ribosome hibernation has_obo_namespace “biological_process”
exit from cytosolic ribosome hibernation has_related_synonym “ribosome reactivation”
exit from cytosolic ribosome hibernation id “GO:7770110”
exit from cytosolic ribosome hibernation definition “A cellular process that results in the reactivation of hibernating cytosolic ribosomes, enabling them to resume translation. Upon reversal of unfavorable conditions such as nutrient limitation, dedicated molecular machinery reactivates hibernating ribosomes and promotes recovery of active translation.”
- database_cross_reference “PMID:32687489”
- database_cross_reference “PMID:42129552”
exit from cytosolic ribosome hibernation label “exit from cytosolic ribosome hibernation”
exit from cytosolic ribosome hibernation SubClassOf positive regulation of cytoplasmic translation

extracellular microvesicle biogenesis `http://purl.obolibrary.org/obo/GO_0140113`

Removed

extracellular microvesicle biogenesis definition “The assembly and secretion of a set of components to form an extracellular microvesicule, a membrane-bounded vesicle that ranges in size 100 nm to 1 micron in size) and exits the cell by budding.”
- database_cross_reference “PMID:28736435”

Added

extracellular microvesicle biogenesis definition “The assembly and secretion of a set of components to form an extracellular microvesicle, a membrane-bounded vesicle that ranges from 100 nm to 1 micron in size and exits the cell by budding.”
- database_cross_reference “PMID:28736435”

extracellular vesicle biogenesis `http://purl.obolibrary.org/obo/GO_0140112`

Removed

extracellular vesicle biogenesis definition “The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content.”
- database_cross_reference “PMID:28736435”

Added

extracellular vesicle biogenesis definition “The assembly and secretion of a set of components to form an extracellular vesicle, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content.”
- database_cross_reference “PMID:28736435”

extrinsic component of phagophore assembly site membrane `http://purl.obolibrary.org/obo/GO_0097632`

Removed

extrinsic component of phagophore assembly site membrane has_exact_synonym “extrinsic to phagophore assembly site membrane”
extrinsic component of phagophore assembly site membrane has_narrow_synonym “extrinsic component of pre-autophagosomal structure membrane”
extrinsic component of phagophore assembly site membrane definition “The component of the phagophore assembly site membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.”
- database_cross_reference “GOC:mf”
extrinsic component of phagophore assembly site membrane label “extrinsic component of phagophore assembly site membrane”
extrinsic component of phagophore assembly site membrane EquivalentTo extrinsic component of membrane and (part of some phagophore assembly site membrane)
extrinsic component of phagophore assembly site membrane SubClassOf extrinsic component of organelle membrane
extrinsic component of phagophore assembly site membrane SubClassOf part of some phagophore assembly site membrane

Added

extrinsic component of phagophore assembly site membrane term tracker item “https://github.com/geneontology/go-ontology/issues/29437”^^anyURI
extrinsic component of phagophore assembly site membrane has_related_synonym “extrinsic component of phagophore assembly site membrane”
extrinsic component of phagophore assembly site membrane has_related_synonym “extrinsic component of pre-autophagosomal structure membrane”
extrinsic component of phagophore assembly site membrane has_related_synonym “extrinsic to phagophore assembly site membrane”
extrinsic component of phagophore assembly site membrane definition “The component of a phagophore membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.”
- database_cross_reference “GOC:mf”
extrinsic component of phagophore assembly site membrane label “extrinsic component of phagophore membrane”
extrinsic component of phagophore assembly site membrane EquivalentTo extrinsic component of membrane and (part of some phagophore membrane)
extrinsic component of phagophore assembly site membrane SubClassOf extrinsic component of membrane
extrinsic component of phagophore assembly site membrane SubClassOf part of some phagophore membrane

formaldehyde assimilation `http://purl.obolibrary.org/obo/GO_0019649`

Added

formaldehyde assimilation SubClassOf nutrient assimilation

fructosamine biosynthetic process `http://purl.obolibrary.org/obo/GO_0030391`

Removed

fructosamine biosynthetic process SubClassOf fructosamine metabolic process

fructosamine catabolic process `http://purl.obolibrary.org/obo/GO_0030392`

Removed

fructosamine catabolic process SubClassOf fructosamine metabolic process

fructosamine metabolic process `http://purl.obolibrary.org/obo/GO_0030389`

Removed

fructosamine metabolic process definition “The chemical reactions and pathways involving fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group.”
- database_cross_reference “GOC:jl”
- database_cross_reference “ISBN:0192801023”
fructosamine metabolic process label “fructosamine metabolic process”
fructosamine metabolic process SubClassOf amino sugar metabolic process

Added

fructosamine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/32273”^^anyURI
fructosamine metabolic process consider fructosamine biosynthetic process
fructosamine metabolic process consider fructosamine catabolic process
fructosamine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group.”
- database_cross_reference “GOC:jl”
- database_cross_reference “ISBN:0192801023”
fructosamine metabolic process deprecated true
fructosamine metabolic process comment “The reason for obsoletion is that this term was made in error and is an unnecessary grouping term.”
fructosamine metabolic process label “obsolete fructosamine metabolic process”

fructose 1,6-bisphosphate 1-phosphatase activity `http://purl.obolibrary.org/obo/GO_0042132`

Removed

fructose 1,6-bisphosphate 1-phosphatase activity has_broad_synonym “fructose-bisphosphatase activity”
- database_cross_reference “EC:3.1.3.00”

Added

fructose 1,6-bisphosphate 1-phosphatase activity has_broad_synonym “fructose-bisphosphatase activity”
- database_cross_reference “EC:3.1.3.11”

fructose export from vacuole to cytoplasm `http://purl.obolibrary.org/obo/GO_1902334`

Removed

fructose export from vacuole to cytoplasm label “fructose export from vacuole to cytoplasm”

Added

fructose export from vacuole to cytoplasm term tracker item “https://github.com/geneontology/go-ontology/issues/32419”^^anyURI
fructose export from vacuole to cytoplasm label “fructose export from vacuole to cytosol”

fructoselysine metabolic process `http://purl.obolibrary.org/obo/GO_0030393`

Removed

fructoselysine metabolic process SubClassOf fructosamine metabolic process

Added

fructoselysine metabolic process SubClassOf amino sugar metabolic process

ganglioside metabolic process `http://purl.obolibrary.org/obo/GO_0001573`

Added

ganglioside metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/32322”^^anyURI

gap endonuclease activity `http://purl.obolibrary.org/obo/GO_0170076`

Added

Class: gap endonuclease activity
gap endonuclease activity term tracker item “https://github.com/geneontology/go-ontology/issues/32367”^^anyURI
gap endonuclease activity created by “ew”
gap endonuclease activity creation date “2026-08-10T17:51:18Z”
gap endonuclease activity has_exact_synonym “GEN activity”
gap endonuclease activity has_exact_synonym “Gap specific endonuclease activity”
gap endonuclease activity has_obo_namespace “molecular_function”
gap endonuclease activity id “GO:0170076”
gap endonuclease activity definition “Specific recognition and catalysis of the internal cleavage of the phosphodiester backbone within single-stranded DNA gaps or looped DNA structures at the junctions of single-stranded and double-stranded DNA. Primarily involved in the resolution of triplet repeat sequences, removal of aberrant secondary structures formed during the maturation of Okazaki fragments, telomeric R-loop resolution and the processing of stalled replication forks, that all involve cleavage at internal or branched DNA structures.”
- database_cross_reference “PMID:15592449”
- database_cross_reference “PMID:10330154”
gap endonuclease activity label “gap endonuclease activity”
gap endonuclease activity SubClassOf DNA endonuclease activity

glucose dehydrogenase (FAD, quinone) activity `http://purl.obolibrary.org/obo/GO_0140762`

Removed

glucose dehydrogenase (FAD, quinone) activity database_cross_reference “MetaCyc:GLUCOSE-DEHYDROGENASE-ACCEPTOR-RXN”
glucose dehydrogenase (FAD, quinone) activity database_cross_reference “RHEA:47372”
glucose dehydrogenase (FAD, quinone) activity exactMatch 47372
glucose dehydrogenase (FAD, quinone) activity definition “Catalysis of the reaction: a quinone + D-glucose = a quinol + D-glucono-1,5-lactone.”
- database_cross_reference “RHEA:47372”

Added

glucose dehydrogenase (FAD, quinone) activity term tracker item “https://github.com/geneontology/go-ontology/issues/32504”^^anyURI
glucose dehydrogenase (FAD, quinone) activity broadMatch GLUCOSE-DEHYDROGENASE-ACCEPTOR-RXN
glucose dehydrogenase (FAD, quinone) activity broadMatch 47372
glucose dehydrogenase (FAD, quinone) activity broadMatch R00305
glucose dehydrogenase (FAD, quinone) activity definition “Catalysis of the reaction: D-glucose + a quinone = D-glucono-1,5-lactone + a quinol, using FAD as a cofactor.”
- database_cross_reference “EC:1.1.5.9”
glucose dehydrogenase (FAD, quinone) activity has_exact_synonym “FAD-dependent glucose dehydrogenase activity”
- database_cross_reference “EC:1.1.5.9”

glutaminyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0006425`

Removed

glutaminyl-tRNA aminoacylation definition “The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. The glutaminyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2’-OH group of a glutamine-accetping tRNA. The 2’-O-aminoacyl-tRNA will ultimately migrate to the 3’ position via transesterification.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
glutaminyl-tRNA aminoacylation label “glutaminyl-tRNA aminoacylation”
glutaminyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for protein translation

Added

glutaminyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
glutaminyl-tRNA aminoacylation term replaced by tRNA aminoacylation for protein translation
glutaminyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. The glutaminyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2’-OH group of a glutamine-accetping tRNA. The 2’-O-aminoacyl-tRNA will ultimately migrate to the 3’ position via transesterification.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
glutaminyl-tRNA aminoacylation deprecated true
glutaminyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004819 glutamine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0006418 tRNA aminoacylation for protein translation.”
glutaminyl-tRNA aminoacylation label “obsolete glutaminyl-tRNA aminoacylation”

glutaminyl-tRNAGln biosynthesis via transamidation `http://purl.obolibrary.org/obo/GO_0070681`

Removed

glutaminyl-tRNAGln biosynthesis via transamidation database_cross_reference “MetaCyc:PWY-5921”
glutaminyl-tRNAGln biosynthesis via transamidation definition “A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase.”
- database_cross_reference “GOC:mah”
- database_cross_reference “MetaCyc:PWY-5921”
glutaminyl-tRNAGln biosynthesis via transamidation label “glutaminyl-tRNAGln biosynthesis via transamidation”
glutaminyl-tRNAGln biosynthesis via transamidation SubClassOf tRNA aminoacylation

Added

glutaminyl-tRNAGln biosynthesis via transamidation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
glutaminyl-tRNAGln biosynthesis via transamidation consider tRNA aminoacylation
glutaminyl-tRNAGln biosynthesis via transamidation consider glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
glutaminyl-tRNAGln biosynthesis via transamidation definition “OBSOLETE. A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase.”
- database_cross_reference “GOC:mah”
- database_cross_reference “MetaCyc:PWY-5921”
glutaminyl-tRNAGln biosynthesis via transamidation deprecated true
glutaminyl-tRNAGln biosynthesis via transamidation comment “The reason for obsoletion is that this term represents a specific pathway variant, which is out of scope for GO, following the obsoletion of its structural twin GO:0070680 asparaginyl-tRNAAsn biosynthesis via transamidation. No replaced_by is given because no single term is a safe automatic substitution: the amidotransferase step is GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity, while GatCAB subunits act on an already-charged tRNA and may belong under GO:0019988 charged-tRNA amino acid modification rather than under tRNA charging at all. Annotations require review rather than migration.”
glutaminyl-tRNAGln biosynthesis via transamidation label “obsolete glutaminyl-tRNAGln biosynthesis via transamidation”

glutamyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0006424`

Removed

glutamyl-tRNA aminoacylation definition “The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. The glutamyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2’-OH group of a glutamic acid-accetping tRNA. The 2’-O-aminoacyl-tRNA will ultimately migrate to the 3’ position via transesterification.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
glutamyl-tRNA aminoacylation label “glutamyl-tRNA aminoacylation”
glutamyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for protein translation

Added

glutamyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
glutamyl-tRNA aminoacylation term replaced by tRNA aminoacylation for protein translation
glutamyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. The glutamyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2’-OH group of a glutamic acid-accetping tRNA. The 2’-O-aminoacyl-tRNA will ultimately migrate to the 3’ position via transesterification.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
glutamyl-tRNA aminoacylation deprecated true
glutamyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004818 glutamate-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0006418 tRNA aminoacylation for protein translation.”
glutamyl-tRNA aminoacylation label “obsolete glutamyl-tRNA aminoacylation”

glutaredoxin-dependent peroxiredoxin activity `http://purl.obolibrary.org/obo/GO_7770099`

Added

Class: glutaredoxin-dependent peroxiredoxin activity
glutaredoxin-dependent peroxiredoxin activity term tracker item “https://github.com/geneontology/go-ontology/issues/32405”^^anyURI
glutaredoxin-dependent peroxiredoxin activity created by “ai4c-agent”
glutaredoxin-dependent peroxiredoxin activity creation date “2026-08-04T17:43:33Z”
glutaredoxin-dependent peroxiredoxin activity database_cross_reference “EC:1.11.1.25”
glutaredoxin-dependent peroxiredoxin activity database_cross_reference “RHEA:62624”
glutaredoxin-dependent peroxiredoxin activity has_exact_synonym “GrxPx activity”
glutaredoxin-dependent peroxiredoxin activity has_obo_namespace “molecular_function”
glutaredoxin-dependent peroxiredoxin activity has_related_synonym “thiol peroxidase activity”
glutaredoxin-dependent peroxiredoxin activity id “GO:7770099”
glutaredoxin-dependent peroxiredoxin activity exactMatch 1.11.1.25
glutaredoxin-dependent peroxiredoxin activity exactMatch 62624
glutaredoxin-dependent peroxiredoxin activity definition “Catalysis of the reaction: [glutaredoxin]-dithiol + a hydroperoxide = [glutaredoxin]-disulfide + an alcohol + H2O.”
- database_cross_reference “RHEA:62624”
- database_cross_reference “PMID:12517450”
- database_cross_reference “PMID:11832487”
glutaredoxin-dependent peroxiredoxin activity label “glutaredoxin-dependent peroxiredoxin activity”
glutaredoxin-dependent peroxiredoxin activity SubClassOf peroxiredoxin activity

glutathione-dependent peroxiredoxin activity `http://purl.obolibrary.org/obo/GO_7770101`

Added

Class: glutathione-dependent peroxiredoxin activity
glutathione-dependent peroxiredoxin activity term tracker item “https://github.com/geneontology/go-ontology/issues/32405”^^anyURI
glutathione-dependent peroxiredoxin activity created by “ai4c-agent”
glutathione-dependent peroxiredoxin activity creation date “2026-08-04T17:43:33Z”
glutathione-dependent peroxiredoxin activity database_cross_reference “EC:1.11.1.27”
glutathione-dependent peroxiredoxin activity database_cross_reference “RHEA:62632”
glutathione-dependent peroxiredoxin activity database_cross_reference “RHEA:69412”
glutathione-dependent peroxiredoxin activity database_cross_reference “RHEA:69651”
glutathione-dependent peroxiredoxin activity database_cross_reference “RHEA:76731”
glutathione-dependent peroxiredoxin activity has_obo_namespace “molecular_function”
glutathione-dependent peroxiredoxin activity has_related_synonym “thiol peroxidase activity”
glutathione-dependent peroxiredoxin activity id “GO:7770101”
glutathione-dependent peroxiredoxin activity exactMatch 1.11.1.27
glutathione-dependent peroxiredoxin activity exactMatch 62632
glutathione-dependent peroxiredoxin activity narrowMatch 69412
glutathione-dependent peroxiredoxin activity narrowMatch 69651
glutathione-dependent peroxiredoxin activity narrowMatch 76731
glutathione-dependent peroxiredoxin activity definition “Catalysis of the reaction: a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.”
- database_cross_reference “RHEA:62632”
- database_cross_reference “PMID:15004285”
- database_cross_reference “PMID:12606554”
glutathione-dependent peroxiredoxin activity label “glutathione-dependent peroxiredoxin activity”
glutathione-dependent peroxiredoxin activity SubClassOf peroxidase activity

glycine decarboxylation via glycine cleavage system `http://purl.obolibrary.org/obo/GO_0019464`

Removed

glycine decarboxylation via glycine cleavage system definition “The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex.”
- database_cross_reference “MetaCyc:GLYCLEAV-PWY”

Added

glycine decarboxylation via glycine cleavage system term tracker item “https://github.com/geneontology/go-ontology/issues/32362”^^anyURI
glycine decarboxylation via glycine cleavage system definition “The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex.”
- database_cross_reference “PMID:41521798”
- database_cross_reference “MetaCyc:GLYCLEAV-PWY”
- database_cross_reference “PMID:36347252”

glycolysis from storage polysaccharide through glucose-1-phosphate `http://purl.obolibrary.org/obo/GO_0093001`

Removed

glycolysis from storage polysaccharide through glucose-1-phosphate definition “The chemical reactions and pathways resulting in the breakdown of a storage polysaccharide into pyruvate through a glucose-1-phosphate intermediate, with the concomitant production of a small amount of ATP and the reduction of NAD to NADH.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:glycolysis”
glycolysis from storage polysaccharide through glucose-1-phosphate label “glycolysis from storage polysaccharide through glucose-1-phosphate”
glycolysis from storage polysaccharide through glucose-1-phosphate SubClassOf polysaccharide catabolic process
glycolysis from storage polysaccharide through glucose-1-phosphate SubClassOf glycolytic process through glucose-1-phosphate

Added

glycolysis from storage polysaccharide through glucose-1-phosphate term tracker item “https://github.com/geneontology/go-ontology/issues/32471”^^anyURI
glycolysis from storage polysaccharide through glucose-1-phosphate term replaced by glycolytic process
glycolysis from storage polysaccharide through glucose-1-phosphate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a storage polysaccharide into pyruvate through a glucose-1-phosphate intermediate, with the concomitant production of a small amount of ATP and the reduction of NAD to NADH.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:glycolysis”
glycolysis from storage polysaccharide through glucose-1-phosphate deprecated true
glycolysis from storage polysaccharide through glucose-1-phosphate comment “The reason for obsoletion is that this term represents a GO-CAM model.”
glycolysis from storage polysaccharide through glucose-1-phosphate label “obsolete glycolysis from storage polysaccharide through glucose-1-phosphate”

glycolytic process `http://purl.obolibrary.org/obo/GO_0006096`

Removed

glycolytic process has_related_synonym “glycolysis”
- database_cross_reference “GOC:dph”
glycolytic process label “glycolytic process”

Added

glycolytic process term tracker item “https://github.com/geneontology/go-ontology/issues/32471”^^anyURI
glycolytic process database_cross_reference “MetaCyc:ANAGLYCOLYSIS-PWY”
glycolytic process database_cross_reference “MetaCyc:GLYCOLYSIS”
glycolytic process database_cross_reference “MetaCyc:PWY-1042”
glycolytic process database_cross_reference “MetaCyc:PWY-5484”
glycolytic process database_cross_reference “MetaCyc:PWY-8404”
glycolytic process has_exact_synonym “glycolytic process”
glycolytic process narrowMatch ANAGLYCOLYSIS-PWY
glycolytic process narrowMatch GLYCOLYSIS
glycolytic process narrowMatch PWY-1042
glycolytic process narrowMatch PWY-5484
glycolytic process narrowMatch PWY-8404
glycolytic process label “glycolysis”

glycolytic process from fructose through fructose-6-phosphate `http://purl.obolibrary.org/obo/GO_0061616`

Removed

glycolytic process from fructose through fructose-6-phosphate definition “The glycolytic process through fructose-6-phosphate in which fructose is catabolized into pyruvate.”
- database_cross_reference “GOC:dph”
- database_cross_reference “ISBN:0879010479”
- database_cross_reference “ISBN:0201090910”
glycolytic process from fructose through fructose-6-phosphate label “glycolytic process from fructose through fructose-6-phosphate”
glycolytic process from fructose through fructose-6-phosphate SubClassOf fructose catabolic process
glycolytic process from fructose through fructose-6-phosphate SubClassOf glycolytic process through fructose-6-phosphate
glycolytic process from fructose through fructose-6-phosphate SubClassOf has part some fructokinase activity

Added

glycolytic process from fructose through fructose-6-phosphate term tracker item “https://github.com/geneontology/go-ontology/issues/32471”^^anyURI
glycolytic process from fructose through fructose-6-phosphate term replaced by glycolytic process
glycolytic process from fructose through fructose-6-phosphate definition “OBSOLETE. The glycolytic process through fructose-6-phosphate in which fructose is catabolized into pyruvate.”
- database_cross_reference “GOC:dph”
- database_cross_reference “ISBN:0879010479”
- database_cross_reference “ISBN:0201090910”
glycolytic process from fructose through fructose-6-phosphate deprecated true
glycolytic process from fructose through fructose-6-phosphate comment “The reason for obsoletion is that this term represents a GO-CAM model.”
glycolytic process from fructose through fructose-6-phosphate label “obsolete glycolytic process from fructose through fructose-6-phosphate”

glycolytic process from galactose `http://purl.obolibrary.org/obo/GO_0061623`

Removed

glycolytic process from galactose definition “The chemical reactions and pathways resulting in the breakdown of galactose into pyruvate, with the concomitant production of a small amount of ATP.”
- database_cross_reference “GOC:dph”
- database_cross_reference “ISBN:0201090910”
glycolytic process from galactose label “glycolytic process from galactose”
glycolytic process from galactose SubClassOf galactose catabolic process
glycolytic process from galactose SubClassOf glycolytic process through glucose-1-phosphate
glycolytic process from galactose SubClassOf has part some beta-D-galactose catabolic process via UDP-galactose, Leloir pathway

Added

glycolytic process from galactose term tracker item “https://github.com/geneontology/go-ontology/issues/32471”^^anyURI
glycolytic process from galactose term replaced by glycolytic process
glycolytic process from galactose definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of galactose into pyruvate, with the concomitant production of a small amount of ATP.”
- database_cross_reference “GOC:dph”
- database_cross_reference “ISBN:0201090910”
glycolytic process from galactose deprecated true
glycolytic process from galactose comment “The reason for obsoletion is that this term represents a GO-CAM model.”
glycolytic process from galactose label “obsolete glycolytic process from galactose”

glycolytic process from mannose through fructose-6-phosphate `http://purl.obolibrary.org/obo/GO_0061619`

Removed

glycolytic process from mannose through fructose-6-phosphate definition “The chemical reactions and pathways resulting in the breakdown of mannose into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH.”
- database_cross_reference “GOC:dph”
- database_cross_reference “ISBN:0879010479”
- database_cross_reference “ISBN:0201090910”
glycolytic process from mannose through fructose-6-phosphate label “glycolytic process from mannose through fructose-6-phosphate”
glycolytic process from mannose through fructose-6-phosphate SubClassOf mannose catabolic process
glycolytic process from mannose through fructose-6-phosphate SubClassOf glycolytic process through fructose-6-phosphate
glycolytic process from mannose through fructose-6-phosphate SubClassOf has part some mannose to fructose-6-phosphate catabolic process

Added

glycolytic process from mannose through fructose-6-phosphate term tracker item “https://github.com/geneontology/go-ontology/issues/32471”^^anyURI
glycolytic process from mannose through fructose-6-phosphate term replaced by glycolytic process
glycolytic process from mannose through fructose-6-phosphate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of mannose into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH.”
- database_cross_reference “GOC:dph”
- database_cross_reference “ISBN:0879010479”
- database_cross_reference “ISBN:0201090910”
glycolytic process from mannose through fructose-6-phosphate deprecated true
glycolytic process from mannose through fructose-6-phosphate comment “The reason for obsoletion is that this term represents a GO-CAM model.”
glycolytic process from mannose through fructose-6-phosphate label “obsolete glycolytic process from mannose through fructose-6-phosphate”

glycolytic process from sucrose `http://purl.obolibrary.org/obo/GO_0061704`

Removed

glycolytic process from sucrose definition “The chemical reactions and pathways resulting in the breakdown of a sucrose into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:glycolysis”
- database_cross_reference “PMID:15012287”
glycolytic process from sucrose label “glycolytic process from sucrose”
glycolytic process from sucrose SubClassOf sucrose catabolic process
glycolytic process from sucrose SubClassOf glycolytic process

Added

glycolytic process from sucrose term tracker item “https://github.com/geneontology/go-ontology/issues/32471”^^anyURI
glycolytic process from sucrose term replaced by glycolytic process
glycolytic process from sucrose definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a sucrose into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:glycolysis”
- database_cross_reference “PMID:15012287”
glycolytic process from sucrose deprecated true
glycolytic process from sucrose comment “The reason for obsoletion is that this term represents a GO-CAM model.”
glycolytic process from sucrose label “obsolete glycolytic process from sucrose”

glycolytic process from sucrose through glucose and fructose `http://purl.obolibrary.org/obo/GO_0061706`

Removed

glycolytic process from sucrose through glucose and fructose database_cross_reference “MetaCyc:PWY-1042”
glycolytic process from sucrose through glucose and fructose definition “The chemical reactions and pathways resulting in the breakdown of sucrose into pyruvate through both glucose and fructose intermediates, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:glycolysis”
- database_cross_reference “MetaCyc:PWY-1042”
- database_cross_reference “PMID:15012287”
glycolytic process from sucrose through glucose and fructose label “glycolytic process from sucrose through glucose and fructose”
glycolytic process from sucrose through glucose and fructose SubClassOf glycolytic process from sucrose

Added

glycolytic process from sucrose through glucose and fructose term tracker item “https://github.com/geneontology/go-ontology/issues/32471”^^anyURI
glycolytic process from sucrose through glucose and fructose term replaced by glycolytic process
glycolytic process from sucrose through glucose and fructose definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of sucrose into pyruvate through both glucose and fructose intermediates, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:glycolysis”
- database_cross_reference “MetaCyc:PWY-1042”
- database_cross_reference “PMID:15012287”
glycolytic process from sucrose through glucose and fructose deprecated true
glycolytic process from sucrose through glucose and fructose comment “The reason for obsoletion is that this term represents a GO-CAM model.”
glycolytic process from sucrose through glucose and fructose label “obsolete glycolytic process from sucrose through glucose and fructose”

glycolytic process through fructose-1-phosphate `http://purl.obolibrary.org/obo/GO_0061625`

Removed

glycolytic process through fructose-1-phosphate database_cross_reference “MetaCyc:PWY-8404”
glycolytic process through fructose-1-phosphate definition “The chemical reactions and pathways resulting in the breakdown of fructose into pyruvate through a fructose-1-phosphate intermediate, with the concomitant production of ATP and NADH.”
- database_cross_reference “GOC:dph”
- database_cross_reference “ISBN:0201090910”
glycolytic process through fructose-1-phosphate label “glycolytic process through fructose-1-phosphate”
glycolytic process through fructose-1-phosphate SubClassOf glycolytic process

Added

glycolytic process through fructose-1-phosphate term tracker item “https://github.com/geneontology/go-ontology/issues/32471”^^anyURI
glycolytic process through fructose-1-phosphate term replaced by glycolytic process
glycolytic process through fructose-1-phosphate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of fructose into pyruvate through a fructose-1-phosphate intermediate, with the concomitant production of ATP and NADH.”
- database_cross_reference “GOC:dph”
- database_cross_reference “ISBN:0201090910”
glycolytic process through fructose-1-phosphate deprecated true
glycolytic process through fructose-1-phosphate comment “The reason for obsoletion is that this term represents a GO-CAM model.”
glycolytic process through fructose-1-phosphate label “obsolete glycolytic process through fructose-1-phosphate”

glycolytic process through fructose-6-phosphate `http://purl.obolibrary.org/obo/GO_0061615`

Removed

glycolytic process through fructose-6-phosphate database_cross_reference “MetaCyc:PWY-5484”
glycolytic process through fructose-6-phosphate definition “The chemical reactions and pathways resulting in the breakdown of a monosaccharide into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH.”
- database_cross_reference “GOC:dph”
- database_cross_reference “ISBN:0879010479”
- database_cross_reference “ISBN:0201090910”
glycolytic process through fructose-6-phosphate label “glycolytic process through fructose-6-phosphate”
glycolytic process through fructose-6-phosphate EquivalentTo glycolytic process and (has part some 6-phosphofructokinase activity) and (has part some fructose-bisphosphate aldolase activity) and (has part some triose-phosphate isomerase activity)
glycolytic process through fructose-6-phosphate SubClassOf glycolytic process
glycolytic process through fructose-6-phosphate SubClassOf has part some 6-phosphofructokinase activity
glycolytic process through fructose-6-phosphate SubClassOf has part some fructose-bisphosphate aldolase activity
glycolytic process through fructose-6-phosphate SubClassOf has part some triose-phosphate isomerase activity

Added

glycolytic process through fructose-6-phosphate term tracker item “https://github.com/geneontology/go-ontology/issues/32471”^^anyURI
glycolytic process through fructose-6-phosphate term replaced by glycolytic process
glycolytic process through fructose-6-phosphate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a monosaccharide into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH.”
- database_cross_reference “GOC:dph”
- database_cross_reference “ISBN:0879010479”
- database_cross_reference “ISBN:0201090910”
glycolytic process through fructose-6-phosphate deprecated true
glycolytic process through fructose-6-phosphate comment “The reason for obsoletion is that this term represents a GO-CAM model.”
glycolytic process through fructose-6-phosphate label “obsolete glycolytic process through fructose-6-phosphate”

glycolytic process through glucose-1-phosphate `http://purl.obolibrary.org/obo/GO_0061622`

Removed

glycolytic process through glucose-1-phosphate definition “The chemical reactions and pathways through a glucose-1-phosphate intermediate that result in the catabolism of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP.”
- database_cross_reference “GOC:dph”
- database_cross_reference “ISBN:0201090910”
glycolytic process through glucose-1-phosphate label “glycolytic process through glucose-1-phosphate”
glycolytic process through glucose-1-phosphate EquivalentTo glycolytic process through glucose-6-phosphate and (has part some phosphoglucomutase activity)
glycolytic process through glucose-1-phosphate SubClassOf glycolytic process through glucose-6-phosphate
glycolytic process through glucose-1-phosphate SubClassOf has part some phosphoglucomutase activity

Added

glycolytic process through glucose-1-phosphate term tracker item “https://github.com/geneontology/go-ontology/issues/32471”^^anyURI
glycolytic process through glucose-1-phosphate term replaced by glycolytic process
glycolytic process through glucose-1-phosphate definition “OBSOLETE. The chemical reactions and pathways through a glucose-1-phosphate intermediate that result in the catabolism of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP.”
- database_cross_reference “GOC:dph”
- database_cross_reference “ISBN:0201090910”
glycolytic process through glucose-1-phosphate deprecated true
glycolytic process through glucose-1-phosphate comment “The reason for obsoletion is that this term represents a GO-CAM model.”
glycolytic process through glucose-1-phosphate label “obsolete glycolytic process through glucose-1-phosphate”

glycolytic process through glucose-6-phosphate `http://purl.obolibrary.org/obo/GO_0061620`

Removed

glycolytic process through glucose-6-phosphate definition “The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, occurring through a glucose-6-phosphate intermediate, with the concomitant production of a small amount of ATP.”
- database_cross_reference “GOC:dph”
- database_cross_reference “ISBN:0879010479”
- database_cross_reference “ISBN:0201090910”
glycolytic process through glucose-6-phosphate label “glycolytic process through glucose-6-phosphate”
glycolytic process through glucose-6-phosphate SubClassOf glycolytic process through fructose-6-phosphate
glycolytic process through glucose-6-phosphate SubClassOf has part some glucose-6-phosphate isomerase activity

Added

glycolytic process through glucose-6-phosphate term tracker item “https://github.com/geneontology/go-ontology/issues/32471”^^anyURI
glycolytic process through glucose-6-phosphate term replaced by glycolytic process
glycolytic process through glucose-6-phosphate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, occurring through a glucose-6-phosphate intermediate, with the concomitant production of a small amount of ATP.”
- database_cross_reference “GOC:dph”
- database_cross_reference “ISBN:0879010479”
- database_cross_reference “ISBN:0201090910”
glycolytic process through glucose-6-phosphate deprecated true
glycolytic process through glucose-6-phosphate comment “The reason for obsoletion is that this term represents a GO-CAM model.”
glycolytic process through glucose-6-phosphate label “obsolete glycolytic process through glucose-6-phosphate”

glycyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0006426`

Removed

glycyl-tRNA aminoacylation definition “The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3’-OH group of a glycine-accepting tRNA.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
glycyl-tRNA aminoacylation label “glycyl-tRNA aminoacylation”
glycyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for protein translation

Added

glycyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
glycyl-tRNA aminoacylation term replaced by tRNA aminoacylation for protein translation
glycyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3’-OH group of a glycine-accepting tRNA.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
glycyl-tRNA aminoacylation deprecated true
glycyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004820 glycine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0006418 tRNA aminoacylation for protein translation.”
glycyl-tRNA aminoacylation label “obsolete glycyl-tRNA aminoacylation”

goslim_euk_cellular_processes_ribbon `http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon`

Removed

goslim_euk_cellular_processes_ribbon comment “GO ribbon for eukaroytic cellular processes”

Added

goslim_euk_cellular_processes_ribbon comment “GO ribbon for eukaryotic cellular processes”

granulocyte colony-stimulating factor signaling pathway `http://purl.obolibrary.org/obo/GO_0038158`

Added

granulocyte colony-stimulating factor signaling pathway term tracker item “https://github.com/geneontology/go-ontology/issues/32373”^^anyURI

group translocator activity `http://purl.obolibrary.org/obo/GO_7770111`

Added

Class: group translocator activity
group translocator activity term tracker item “https://github.com/geneontology/go-ontology/issues/27496”^^anyURI
group translocator activity created by “ai4c-agent”
group translocator activity creation date “2026-08-18T00:41:26Z”
group translocator activity database_cross_reference “TC:4”
group translocator activity has_exact_synonym “group translocation activity”
group translocator activity has_obo_namespace “molecular_function”
group translocator activity has_related_synonym “group translocator”
group translocator activity id “GO:7770111”
group translocator activity definition “Enables the transfer of a substance from one side of a membrane to the other, where the substance is chemically modified as an integral part of the translocation process, so that the species released on the far side of the membrane is not the species that was bound on the near side. This differs from primary and secondary active transport, in which the transported substance is unchanged.”
- database_cross_reference “PMID:31214989”
- database_cross_reference “PMID:33170213”
group translocator activity label “group translocator activity”
group translocator activity SubClassOf transmembrane transporter activity
group translocator activity SubClassOf has part some catalytic activity

heme A synthase activity `http://purl.obolibrary.org/obo/GO_0120547`

Removed

heme A synthase activity definition “Catalysis of the reaction: Fe(II)-heme o + 2 acceptor + H2O = Fe(II)-heme a + 2 acceptor-H2. The conversion of heme o to heme a occcurs by two successive hydroxylations of the methyl group at C8 using water as the oxygen source. The first hydroxylation forms heme i, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.”
- database_cross_reference “PMID:30397130”
- database_cross_reference “RHEA:63388”

Added

heme A synthase activity definition “Catalysis of the reaction: Fe(II)-heme o + 2 acceptor + H2O = Fe(II)-heme a + 2 acceptor-H2. The conversion of heme o to heme a occurs by two successive hydroxylations of the methyl group at C8 using water as the oxygen source. The first hydroxylation forms heme i, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.”
- database_cross_reference “PMID:30397130”
- database_cross_reference “RHEA:63388”

heme export from vacuole to cytoplasm `http://purl.obolibrary.org/obo/GO_0140357`

Removed

heme export from vacuole to cytoplasm label “heme export from vacuole to cytoplasm”

Added

heme export from vacuole to cytoplasm term tracker item “https://github.com/geneontology/go-ontology/issues/32419”^^anyURI
heme export from vacuole to cytoplasm label “heme export from vacuole to cytosol”

heterochromatin domain `http://purl.obolibrary.org/obo/GO_1990343`

Removed

heterochromatin domain definition “A region of heterochromatin that is formed dynamically under specific growth conditions by a process that requires RNAi, and is enriched in histone H3 methylated on lysine 9 (H3K9me).”
- database_cross_reference “PMID:24210919”
- database_cross_reference “PMID:23151475”
heterochromatin domain comment “An example of this type of heterochromatin is found in Schizosaccharomyces pombe, where heterochromatin domains preferentially assemble at sexual differentiation genes and retrotransposons.”
heterochromatin domain label “heterochromatin domain”
heterochromatin domain SubClassOf heterochromatin

Added

heterochromatin domain term tracker item “https://github.com/geneontology/go-ontology/issues/26839”^^anyURI
heterochromatin domain consider heterochromatin
heterochromatin domain definition “OBSOLETE. A region of heterochromatin that is formed dynamically under specific growth conditions by a process that requires RNAi, and is enriched in histone H3 methylated on lysine 9 (H3K9me).”
- database_cross_reference “PMID:24210919”
- database_cross_reference “PMID:23151475”
heterochromatin domain deprecated true
heterochromatin domain comment “The reason for obsoletion is that this term was added in error.”
heterochromatin domain label “obsolete heterochromatin domain”

histidyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0006427`

Removed

histidyl-tRNA aminoacylation definition “The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3’‘-OH group of a histidine-accetping tRNA.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
histidyl-tRNA aminoacylation label “histidyl-tRNA aminoacylation”
histidyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for protein translation

Added

histidyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
histidyl-tRNA aminoacylation term replaced by tRNA aminoacylation for protein translation
histidyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3’‘-OH group of a histidine-accetping tRNA.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
histidyl-tRNA aminoacylation deprecated true
histidyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004821 histidine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0006418 tRNA aminoacylation for protein translation.”
histidyl-tRNA aminoacylation label “obsolete histidyl-tRNA aminoacylation”

host-mediated suppression of viral proces `http://purl.obolibrary.org/obo/GO_0044793`

Removed

host-mediated suppression of viral proces label “host-mediated suppression of viral proces”

Added

host-mediated suppression of viral proces label “host-mediated suppression of viral process”

hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity `http://purl.obolibrary.org/obo/GO_0043802`

Removed

hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity label “hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity”

Added

hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity label “hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing) activity”

interleukin-5-mediated signaling pathway `http://purl.obolibrary.org/obo/GO_0038043`

Added

interleukin-5-mediated signaling pathway SubClassOf part of some cellular response to interleukin-5

interphotoreceptor matrix `http://purl.obolibrary.org/obo/GO_0033165`

Removed

interphotoreceptor matrix definition “A specialized extracellularc matrix that surrounds the photoreceptors of the retina and lies between them and the apical surface of the retinal pigment epithelium. The IPM has been implicated in several important activities required for photoreceptor function and maintenance.”
- database_cross_reference “PMID:1862095”
- database_cross_reference “PMID:2194288”

Added

interphotoreceptor matrix definition “A specialized extracellular matrix that surrounds the photoreceptors of the retina and lies between them and the apical surface of the retinal pigment epithelium. The IPM has been implicated in several important activities required for photoreceptor function and maintenance.”
- database_cross_reference “PMID:1862095”
- database_cross_reference “PMID:2194288”

intracellular organelle lumen `http://purl.obolibrary.org/obo/GO_0070013`

Added

intracellular organelle lumen term tracker item “https://github.com/geneontology/go-ontology/issues/32294”^^anyURI
intracellular organelle lumen in_subset gocheck_do_not_annotate

inward rectifier potassium channel inhibitor activity `http://purl.obolibrary.org/obo/GO_0070320`

Removed

inward rectifier potassium channel inhibitor activity SubClassOf potassium channel inhibitor activity

Added

inward rectifier potassium channel inhibitor activity SubClassOf voltage-gated potassium channel inhibitor activity

isoleucyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0006428`

Removed

isoleucyl-tRNA aminoacylation definition “The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2’-OH group of a isoleucine-accetping tRNA. The 2’-O-aminoacyl-tRNA will ultimately migrate to the 3’ position via transesterification.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
isoleucyl-tRNA aminoacylation label “isoleucyl-tRNA aminoacylation”
isoleucyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for protein translation

Added

isoleucyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
isoleucyl-tRNA aminoacylation term replaced by tRNA aminoacylation for protein translation
isoleucyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2’-OH group of a isoleucine-accetping tRNA. The 2’-O-aminoacyl-tRNA will ultimately migrate to the 3’ position via transesterification.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
isoleucyl-tRNA aminoacylation deprecated true
isoleucyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004822 isoleucine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0006418 tRNA aminoacylation for protein translation.”
isoleucyl-tRNA aminoacylation label “obsolete isoleucyl-tRNA aminoacylation”

large conductance calcium-activated potassium channel inhibitor activity `http://purl.obolibrary.org/obo/GO_7770089`

Added

Class: large conductance calcium-activated potassium channel inhibitor activity
large conductance calcium-activated potassium channel inhibitor activity term tracker item “https://github.com/geneontology/go-ontology/issues/32358”^^anyURI
large conductance calcium-activated potassium channel inhibitor activity created by “ai4c-agent”
large conductance calcium-activated potassium channel inhibitor activity creation date “2026-07-28T00:46:41Z”
large conductance calcium-activated potassium channel inhibitor activity has_exact_synonym “BK KCa channel inhibitor activity”
large conductance calcium-activated potassium channel inhibitor activity has_exact_synonym “BK calcium-activated potassium channel inhibitor activity”
large conductance calcium-activated potassium channel inhibitor activity has_exact_synonym “large conductance KCa channel inhibitor activity”
large conductance calcium-activated potassium channel inhibitor activity has_obo_namespace “molecular_function”
large conductance calcium-activated potassium channel inhibitor activity has_related_synonym “BK channel inhibitor activity”
large conductance calcium-activated potassium channel inhibitor activity id “GO:7770089”
large conductance calcium-activated potassium channel inhibitor activity definition “Binds to and stops, prevents, or reduces the activity of a large conductance calcium-activated potassium channel.”
- database_cross_reference “PMID:39971906”
- database_cross_reference “PMID:17591990”
large conductance calcium-activated potassium channel inhibitor activity label “large conductance calcium-activated potassium channel inhibitor activity”
large conductance calcium-activated potassium channel inhibitor activity SubClassOf potassium channel inhibitor activity
large conductance calcium-activated potassium channel inhibitor activity SubClassOf negatively regulates some large conductance calcium-activated potassium channel activity

larval heart development `http://purl.obolibrary.org/obo/GO_0007508`

Removed

larval heart development definition “The process whose specific outcome is the progression of the larval heart over time, from its formation to the mature structure. In Drosophila the larval heart (dorsal vessel) is a continuous tube of mesodormal cells that runs beneath the dorsal midline of the epidermis, divided into an anterior aorta and a posterior heart proper.”
- database_cross_reference “GOC:bf”
- database_cross_reference “ISBN:0879694238”

Added

larval heart development definition “The process whose specific outcome is the progression of the larval heart over time, from its formation to the mature structure. In Drosophila the larval heart (dorsal vessel) is a continuous tube of mesodermal cells that runs beneath the dorsal midline of the epidermis, divided into an anterior aorta and a posterior heart proper.”
- database_cross_reference “GOC:bf”
- database_cross_reference “ISBN:0879694238”

leucyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0006429`

Removed

leucyl-tRNA aminoacylation definition “The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2’-OH group of a leucine-accetping tRNA. The 2’-O-aminoacyl-tRNA will ultimately migrate to the 3’ position via transesterification.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
leucyl-tRNA aminoacylation label “leucyl-tRNA aminoacylation”
leucyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for protein translation

Added

leucyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
leucyl-tRNA aminoacylation term replaced by tRNA aminoacylation for protein translation
leucyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2’-OH group of a leucine-accetping tRNA. The 2’-O-aminoacyl-tRNA will ultimately migrate to the 3’ position via transesterification.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
leucyl-tRNA aminoacylation deprecated true
leucyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004823 leucine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0006418 tRNA aminoacylation for protein translation.”
leucyl-tRNA aminoacylation label “obsolete leucyl-tRNA aminoacylation”

leukocyte mediated cytotoxicity `http://purl.obolibrary.org/obo/GO_0001909`

Removed

leukocyte mediated cytotoxicity comment “Note that this term and its children describe contact-dependent killing of target cells by lymphocytes and myeloid cells of the immune system.”

Added

leukocyte mediated cytotoxicity term tracker item “https://github.com/geneontology/go-ontology/issues/20574”^^anyURI
leukocyte mediated cytotoxicity comment “Note that this term and its children describe contact-dependent killing of target cells by lymphocytes and myeloid cells of the immune system. The is_a links to GO:0001906 and GO:0002443 are asserted rather than inferred because this term has no logical definition; they must be maintained by hand (see #20574).”

leukocyte mediated immunity `http://purl.obolibrary.org/obo/GO_0002443`

Added

leukocyte mediated immunity term tracker item “https://github.com/geneontology/go-ontology/issues/20574”^^anyURI
leukocyte mediated immunity comment “This term intentionally has no logical definition: it is a grouping class covering everything leukocytes do immunologically, and no relation in GO expresses that role as necessary and sufficient conditions. Subclasses must be asserted by hand (see #20574).”

lipid X metabolic process `http://purl.obolibrary.org/obo/GO_2001289`

Removed

lipid X metabolic process definition “The chemical reactions and pathways involving lipid X, 2,3-diacylglucosamine 1-phosphate.”
- database_cross_reference “GOC:obol”
lipid X metabolic process label “lipid X metabolic process”
lipid X metabolic process SubClassOf amino sugar metabolic process
lipid X metabolic process SubClassOf organophosphate metabolic process

Added

lipid X metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/32273”^^anyURI
lipid X metabolic process definition “OBSOLETE. The chemical reactions and pathways involving lipid X, 2,3-diacylglucosamine 1-phosphate.”
- database_cross_reference “GOC:obol”
lipid X metabolic process deprecated true
lipid X metabolic process comment “The reason for obsoletion is that this term was made in error and is an unnecessary grouping term.”
lipid X metabolic process label “obsolete lipid X metabolic process”

lipoate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009107`

Removed

lipoate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid.”
- database_cross_reference “GOC:ai”
- database_cross_reference “ISBN:0198506732”
lipoate biosynthetic process label “lipoate biosynthetic process”
lipoate biosynthetic process SubClassOf fatty acid biosynthetic process
lipoate biosynthetic process SubClassOf lipoate metabolic process
lipoate biosynthetic process SubClassOf sulfur compound biosynthetic process

Added

lipoate biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/32418”^^anyURI
lipoate biosynthetic process term replaced by protein lipoylation
lipoate biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid.”
- database_cross_reference “GOC:ai”
- database_cross_reference “ISBN:0198506732”
lipoate biosynthetic process deprecated true
lipoate biosynthetic process comment “The reason for obsoletion is that the term usage has been inconsistent.”
lipoate biosynthetic process label “obsolete lipoate biosynthetic process”

lipoate synthase activity `http://purl.obolibrary.org/obo/GO_0016992`

Removed

lipoate synthase activity SubClassOf part of some lipoate biosynthetic process

Added

lipoate synthase activity SubClassOf part of some protein lipoylation

lipoyl-GcvH:protein N-lipoyltransferase activity `http://purl.obolibrary.org/obo/GO_7770091`

Added

Class: lipoyl-GcvH:protein N-lipoyltransferase activity
lipoyl-GcvH:protein N-lipoyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32361”^^anyURI
lipoyl-GcvH:protein N-lipoyltransferase activity created by “ai4c-agent”
lipoyl-GcvH:protein N-lipoyltransferase activity creation date “2026-07-28T20:08:06Z”
lipoyl-GcvH:protein N-lipoyltransferase activity has_broad_synonym “lipoyl amidotransferase activity”
lipoyl-GcvH:protein N-lipoyltransferase activity database_cross_reference “EC:2.3.1.204”
lipoyl-GcvH:protein N-lipoyltransferase activity database_cross_reference “RHEA:16413”
lipoyl-GcvH:protein N-lipoyltransferase activity database_cross_reference “RHEA:20213”
lipoyl-GcvH:protein N-lipoyltransferase activity has_obo_namespace “molecular_function”
lipoyl-GcvH:protein N-lipoyltransferase activity has_related_synonym “lipoyl relay activity”
lipoyl-GcvH:protein N-lipoyltransferase activity has_related_synonym “octanoyl-[GcvH]:protein N-octanoyltransferase activity”
lipoyl-GcvH:protein N-lipoyltransferase activity id “GO:7770091”
lipoyl-GcvH:protein N-lipoyltransferase activity exactMatch 2.3.1.204
lipoyl-GcvH:protein N-lipoyltransferase activity narrowMatch 16413
lipoyl-GcvH:protein N-lipoyltransferase activity narrowMatch 20213
lipoyl-GcvH:protein N-lipoyltransferase activity definition “Catalysis of the reaction: N6-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + L-lysyl-[lipoyl-carrier protein] = L-lysyl-[glycine-cleavage complex H protein] + N6-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein].”
- database_cross_reference “PMID:38624243”
- database_cross_reference “EC:2.3.1.204”
lipoyl-GcvH:protein N-lipoyltransferase activity comment “The enzyme also transfers the biosynthetic precursor octanoyl group, and relays the acyl group from GcvH onto the E2 subunits of the pyruvate, 2-oxoglutarate, branched-chain 2-oxoacid and acetoin dehydrogenase complexes.”
lipoyl-GcvH:protein N-lipoyltransferase activity label “lipoyl-GcvH:protein N-lipoyltransferase activity”
lipoyl-GcvH:protein N-lipoyltransferase activity SubClassOf acyltransferase activity, transferring groups other than amino-acyl groups
lipoyl-GcvH:protein N-lipoyltransferase activity SubClassOf catalytic activity, acting on a protein

long-chain fatty acid omega-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0102033`

Added

long-chain fatty acid omega-hydroxylase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32503”^^anyURI
long-chain fatty acid omega-hydroxylase activity database_cross_reference “KEGG_REACTION:R07041”
long-chain fatty acid omega-hydroxylase activity database_cross_reference “MetaCyc:RXN-19677”
long-chain fatty acid omega-hydroxylase activity database_cross_reference “RHEA:39755”
long-chain fatty acid omega-hydroxylase activity narrowMatch RXN-19677
long-chain fatty acid omega-hydroxylase activity narrowMatch 39755
long-chain fatty acid omega-hydroxylase activity narrowMatch R07041

lysyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0006430`

Removed

lysyl-tRNA aminoacylation definition “The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3’-OH group of a lysine-accetping tRNA.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
lysyl-tRNA aminoacylation label “lysyl-tRNA aminoacylation”
lysyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for protein translation

Added

lysyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
lysyl-tRNA aminoacylation term replaced by tRNA aminoacylation for protein translation
lysyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3’-OH group of a lysine-accetping tRNA.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
lysyl-tRNA aminoacylation deprecated true
lysyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004824 lysine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0006418 tRNA aminoacylation for protein translation.”
lysyl-tRNA aminoacylation label “obsolete lysyl-tRNA aminoacylation”

mRNA m(6)A methyltransferase activity `http://purl.obolibrary.org/obo/GO_0001734`

Added

mRNA m(6)A methyltransferase activity SubClassOf RNA (adenine-N6)-methyltransferase activity

macromolecule depalmitoylation `http://purl.obolibrary.org/obo/GO_0098734`

Removed

macromolecule depalmitoylation definition “The removal of palymitoyl groups from a macromolecule.”
- database_cross_reference “GOC:dos”
macromolecule depalmitoylation label “macromolecule depalmitoylation”
macromolecule depalmitoylation SubClassOf macromolecule deacylation

Added

macromolecule depalmitoylation term tracker item “https://github.com/geneontology/go-ontology/issues/32290”^^anyURI
macromolecule depalmitoylation consider palmitoyl-(protein) hydrolase activity
macromolecule depalmitoylation consider palmitoyl hydrolase activity
macromolecule depalmitoylation definition “OBSOLETE. The removal of palymitoyl groups from a macromolecule.”
- database_cross_reference “GOC:dos”
macromolecule depalmitoylation deprecated true
macromolecule depalmitoylation comment “The reason for obsoletion is that this term represents a molecular function, not a biological process. Consider instead annotating to the molecular function ‘palmitoyl hydrolase activity’ (GO:0098599), or, for protein substrates, ‘palmitoyl-(protein) hydrolase activity’ (GO:0008474).”
macromolecule depalmitoylation label “obsolete macromolecule depalmitoylation”

maintenance of bipolar cell polarity regulating cell shape `http://purl.obolibrary.org/obo/GO_0061305`

Removed

maintenance of bipolar cell polarity regulating cell shape definition “The maintenance of established bipolar anisotropic intracellular organization or cell growth patterns that results in the shaping of a cell.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:vw”
maintenance of bipolar cell polarity regulating cell shape label “maintenance of bipolar cell polarity regulating cell shape”
maintenance of bipolar cell polarity regulating cell shape SubClassOf establishment or maintenance of bipolar cell polarity regulating cell shape

Added

maintenance of bipolar cell polarity regulating cell shape term tracker item “https://github.com/geneontology/go-ontology/issues/21217”^^anyURI
maintenance of bipolar cell polarity regulating cell shape term replaced by establishment or maintenance of bipolar cell polarity
maintenance of bipolar cell polarity regulating cell shape definition “OBSOLETE. The maintenance of established bipolar anisotropic intracellular organization or cell growth patterns that results in the shaping of a cell.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:vw”
maintenance of bipolar cell polarity regulating cell shape deprecated true
maintenance of bipolar cell polarity regulating cell shape comment “The reason for obsoletion is that these terms were added in error.”
maintenance of bipolar cell polarity regulating cell shape label “obsolete maintenance of bipolar cell polarity regulating cell shape”

maintenance of seed dormancy by absisic acid `http://purl.obolibrary.org/obo/GO_0098755`

Removed

maintenance of seed dormancy by absisic acid definition “The process by which seed dormancy is maintained by the presence of absisic acid.”
- database_cross_reference “PMID:9580097”
- database_cross_reference “GOC:dos”
maintenance of seed dormancy by absisic acid label “maintenance of seed dormancy by absisic acid”

Added

maintenance of seed dormancy by absisic acid definition “The process by which seed dormancy is maintained by the presence of abscisic acid.”
- database_cross_reference “PMID:9580097”
- database_cross_reference “GOC:dos”
maintenance of seed dormancy by absisic acid label “maintenance of seed dormancy by abscisic acid”

mannosyl-oligosaccharide 1,2-alpha-mannosidase complex `http://purl.obolibrary.org/obo/GO_0106055`

Removed

mannosyl-oligosaccharide 1,2-alpha-mannosidase complex definition “A protein complex capable of catalysing the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide.”
- database_cross_reference “GOC:bhm”
- database_cross_reference “PMID:21700223”

Added

mannosyl-oligosaccharide 1,2-alpha-mannosidase complex definition “A protein complex capable of catalyzing the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide.”
- database_cross_reference “GOC:bhm”
- database_cross_reference “PMID:21700223”

maternal determination of anterior/posterior axis, embryo `http://purl.obolibrary.org/obo/GO_0008358`

Removed

maternal determination of anterior/posterior axis, embryo definition “The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

maternal determination of anterior/posterior axis, embryo term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
maternal determination of anterior/posterior axis, embryo definition “The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos.”
- database_cross_reference “ISBN:0879694238”

meiosis II cell cycle process `http://purl.obolibrary.org/obo/GO_0061983`

Removed

meiosis II cell cycle process definition “A process that coontributes to the second meiotic division. The second meiotic division separates chromatids resulting in a haploid number of chromosomes.”
- database_cross_reference “PMID:29385397”

Added

meiosis II cell cycle process definition “A process that contributes to the second meiotic division. The second meiotic division separates chromatids resulting in a haploid number of chromosomes.”
- database_cross_reference “PMID:29385397”

meiotic metaphase I homologous chromosome alignment `http://purl.obolibrary.org/obo/GO_0043060`

Removed

meiotic metaphase I homologous chromosome alignment definition “A cell cycle process whereby homlogous chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator) by the spindle machinery and centromere/kinetochore arrangement during meiosis I chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division.”
- database_cross_reference “PMID:10809666”

Added

meiotic metaphase I homologous chromosome alignment definition “A cell cycle process whereby homologous chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator) by the spindle machinery and centromere/kinetochore arrangement during meiosis I chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division.”
- database_cross_reference “PMID:10809666”

membrane addition at site of mitotic cytokinesis `http://purl.obolibrary.org/obo/GO_0061796`

Removed

membrane addition at site of mitotic cytokinesis definition “A mitotic cell cycle process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:vw”
membrane addition at site of mitotic cytokinesis label “membrane addition at site of mitotic cytokinesis”
membrane addition at site of mitotic cytokinesis EquivalentTo membrane addition at site of cytokinesis and (part of some mitotic cell cycle)
membrane addition at site of mitotic cytokinesis SubClassOf membrane addition at site of cytokinesis
membrane addition at site of mitotic cytokinesis SubClassOf mitotic cytokinetic process

Added

membrane addition at site of mitotic cytokinesis term tracker item “https://github.com/geneontology/go-ontology/issues/31687”^^anyURI
membrane addition at site of mitotic cytokinesis consider exocytosis
membrane addition at site of mitotic cytokinesis definition “OBSOLETE. A mitotic cell cycle process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:vw”
membrane addition at site of mitotic cytokinesis deprecated true
membrane addition at site of mitotic cytokinesis comment “The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.”
membrane addition at site of mitotic cytokinesis label “obsolete membrane addition at site of mitotic cytokinesis”

membrane insertase activity `http://purl.obolibrary.org/obo/GO_0032977`

Removed

membrane insertase activity SubClassOf part of some establishment of protein localization to membrane

Added

membrane insertase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32404”^^anyURI

methionyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0006431`

Removed

methionyl-tRNA aminoacylation definition “The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2’-OH group of a methionine-accetping tRNA. The 2’-O-aminoacyl-tRNA will ultimately migrate to the 3’ position via transesterification.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
methionyl-tRNA aminoacylation label “methionyl-tRNA aminoacylation”
methionyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for protein translation

Added

methionyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
methionyl-tRNA aminoacylation term replaced by tRNA aminoacylation for protein translation
methionyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2’-OH group of a methionine-accetping tRNA. The 2’-O-aminoacyl-tRNA will ultimately migrate to the 3’ position via transesterification.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
methionyl-tRNA aminoacylation deprecated true
methionyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004825 methionine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0006418 tRNA aminoacylation for protein translation.”
methionyl-tRNA aminoacylation label “obsolete methionyl-tRNA aminoacylation”

microglial cell mediated cytotoxicity `http://purl.obolibrary.org/obo/GO_0090634`

Added

microglial cell mediated cytotoxicity term tracker item “https://github.com/geneontology/go-ontology/issues/20574”^^anyURI
microglial cell mediated cytotoxicity comment “The is_a link to GO:0002444 is asserted rather than inferred because GO:0002444 has no logical definition; it must be maintained by hand (see #20574).”

mitochondrial alanyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0070143`

Removed

mitochondrial alanyl-tRNA aminoacylation definition “The process of coupling alanine to alanyl-tRNA in a mitochondrion, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial alanyl-tRNA aminoacylation label “mitochondrial alanyl-tRNA aminoacylation”
mitochondrial alanyl-tRNA aminoacylation EquivalentTo alanyl-tRNA aminoacylation and (occurs in some mitochondrion)
mitochondrial alanyl-tRNA aminoacylation SubClassOf alanyl-tRNA aminoacylation
mitochondrial alanyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for mitochondrial protein translation

Added

mitochondrial alanyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
mitochondrial alanyl-tRNA aminoacylation term replaced by tRNA aminoacylation for mitochondrial protein translation
mitochondrial alanyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling alanine to alanyl-tRNA in a mitochondrion, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial alanyl-tRNA aminoacylation deprecated true
mitochondrial alanyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004813 alanine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0070127 tRNA aminoacylation for mitochondrial protein translation.”
mitochondrial alanyl-tRNA aminoacylation label “obsolete mitochondrial alanyl-tRNA aminoacylation”

mitochondrial arginyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0070144`

Removed

mitochondrial arginyl-tRNA aminoacylation definition “The process of coupling arginine to arginyl-tRNA in a mitochondrion, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial arginyl-tRNA aminoacylation label “mitochondrial arginyl-tRNA aminoacylation”
mitochondrial arginyl-tRNA aminoacylation EquivalentTo arginyl-tRNA aminoacylation and (occurs in some mitochondrion)
mitochondrial arginyl-tRNA aminoacylation SubClassOf arginyl-tRNA aminoacylation
mitochondrial arginyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for mitochondrial protein translation

Added

mitochondrial arginyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
mitochondrial arginyl-tRNA aminoacylation term replaced by tRNA aminoacylation for mitochondrial protein translation
mitochondrial arginyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling arginine to arginyl-tRNA in a mitochondrion, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial arginyl-tRNA aminoacylation deprecated true
mitochondrial arginyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004814 arginine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0070127 tRNA aminoacylation for mitochondrial protein translation.”
mitochondrial arginyl-tRNA aminoacylation label “obsolete mitochondrial arginyl-tRNA aminoacylation”

mitochondrial asparaginyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0070145`

Removed

mitochondrial asparaginyl-tRNA aminoacylation definition “The process of coupling asparagine to asparaginyl-tRNA in a mitochondrion, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial asparaginyl-tRNA aminoacylation label “mitochondrial asparaginyl-tRNA aminoacylation”
mitochondrial asparaginyl-tRNA aminoacylation EquivalentTo asparaginyl-tRNA aminoacylation and (occurs in some mitochondrion)
mitochondrial asparaginyl-tRNA aminoacylation SubClassOf asparaginyl-tRNA aminoacylation
mitochondrial asparaginyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for mitochondrial protein translation

Added

mitochondrial asparaginyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
mitochondrial asparaginyl-tRNA aminoacylation term replaced by tRNA aminoacylation for mitochondrial protein translation
mitochondrial asparaginyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling asparagine to asparaginyl-tRNA in a mitochondrion, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial asparaginyl-tRNA aminoacylation deprecated true
mitochondrial asparaginyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004816 asparagine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0070127 tRNA aminoacylation for mitochondrial protein translation.”
mitochondrial asparaginyl-tRNA aminoacylation label “obsolete mitochondrial asparaginyl-tRNA aminoacylation”

mitochondrial aspartyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0070146`

Removed

mitochondrial aspartyl-tRNA aminoacylation definition “The process of coupling aspartate to aspartyl-tRNA in a mitochondrion, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial aspartyl-tRNA aminoacylation label “mitochondrial aspartyl-tRNA aminoacylation”
mitochondrial aspartyl-tRNA aminoacylation EquivalentTo aspartyl-tRNA aminoacylation and (occurs in some mitochondrion)
mitochondrial aspartyl-tRNA aminoacylation SubClassOf aspartyl-tRNA aminoacylation
mitochondrial aspartyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for mitochondrial protein translation

Added

mitochondrial aspartyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
mitochondrial aspartyl-tRNA aminoacylation term replaced by tRNA aminoacylation for mitochondrial protein translation
mitochondrial aspartyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling aspartate to aspartyl-tRNA in a mitochondrion, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial aspartyl-tRNA aminoacylation deprecated true
mitochondrial aspartyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004815 aspartate-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0070127 tRNA aminoacylation for mitochondrial protein translation.”
mitochondrial aspartyl-tRNA aminoacylation label “obsolete mitochondrial aspartyl-tRNA aminoacylation”

mitochondrial cysteinyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0070147`

Removed

mitochondrial cysteinyl-tRNA aminoacylation definition “The process of coupling L-cysteine to cysteinyl-tRNA in a mitochondrion, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial cysteinyl-tRNA aminoacylation label “mitochondrial cysteinyl-tRNA aminoacylation”
mitochondrial cysteinyl-tRNA aminoacylation EquivalentTo cysteinyl-tRNA aminoacylation and (occurs in some mitochondrion)
mitochondrial cysteinyl-tRNA aminoacylation SubClassOf cysteinyl-tRNA aminoacylation
mitochondrial cysteinyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for mitochondrial protein translation

Added

mitochondrial cysteinyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
mitochondrial cysteinyl-tRNA aminoacylation term replaced by tRNA aminoacylation for mitochondrial protein translation
mitochondrial cysteinyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling L-cysteine to cysteinyl-tRNA in a mitochondrion, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial cysteinyl-tRNA aminoacylation deprecated true
mitochondrial cysteinyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004817 cysteine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0070127 tRNA aminoacylation for mitochondrial protein translation.”
mitochondrial cysteinyl-tRNA aminoacylation label “obsolete mitochondrial cysteinyl-tRNA aminoacylation”

mitochondrial glutaminyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0070148`

Removed

mitochondrial glutaminyl-tRNA aminoacylation definition “The process of coupling glutamine to glutaminyl-tRNA in a mitochondrion, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial glutaminyl-tRNA aminoacylation label “mitochondrial glutaminyl-tRNA aminoacylation”
mitochondrial glutaminyl-tRNA aminoacylation EquivalentTo glutaminyl-tRNA aminoacylation and (occurs in some mitochondrion)
mitochondrial glutaminyl-tRNA aminoacylation SubClassOf glutaminyl-tRNA aminoacylation
mitochondrial glutaminyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for mitochondrial protein translation

Added

mitochondrial glutaminyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
mitochondrial glutaminyl-tRNA aminoacylation term replaced by tRNA aminoacylation for mitochondrial protein translation
mitochondrial glutaminyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling glutamine to glutaminyl-tRNA in a mitochondrion, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial glutaminyl-tRNA aminoacylation deprecated true
mitochondrial glutaminyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function and adds nothing beyond it. Note that the counterpart is not a glutamine-tRNA ligase in most eukaryotes: mitochondria generally encode no mitochondrial GlnRS, and mt-tRNA(Gln) is charged indirectly by a non-discriminating mitochondrial GluRS followed by the GatCAB amidotransferase, which is GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. GO:0004819 glutamine-tRNA ligase activity applies only where a mitochondrial GlnRS is present. The biological process is covered by GO:0070127 tRNA aminoacylation for mitochondrial protein translation.”
mitochondrial glutaminyl-tRNA aminoacylation label “obsolete mitochondrial glutaminyl-tRNA aminoacylation”

mitochondrial glutamyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0070149`

Removed

mitochondrial glutamyl-tRNA aminoacylation definition “The process of coupling glutamate to glutamyl-tRNA in a mitochondrion, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial glutamyl-tRNA aminoacylation label “mitochondrial glutamyl-tRNA aminoacylation”
mitochondrial glutamyl-tRNA aminoacylation EquivalentTo glutamyl-tRNA aminoacylation and (occurs in some mitochondrion)
mitochondrial glutamyl-tRNA aminoacylation SubClassOf glutamyl-tRNA aminoacylation
mitochondrial glutamyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for mitochondrial protein translation

Added

mitochondrial glutamyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
mitochondrial glutamyl-tRNA aminoacylation term replaced by tRNA aminoacylation for mitochondrial protein translation
mitochondrial glutamyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling glutamate to glutamyl-tRNA in a mitochondrion, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial glutamyl-tRNA aminoacylation deprecated true
mitochondrial glutamyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004818 glutamate-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0070127 tRNA aminoacylation for mitochondrial protein translation.”
mitochondrial glutamyl-tRNA aminoacylation label “obsolete mitochondrial glutamyl-tRNA aminoacylation”

mitochondrial glycyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0070150`

Removed

mitochondrial glycyl-tRNA aminoacylation definition “The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial glycyl-tRNA aminoacylation label “mitochondrial glycyl-tRNA aminoacylation”
mitochondrial glycyl-tRNA aminoacylation EquivalentTo glycyl-tRNA aminoacylation and (occurs in some mitochondrion)
mitochondrial glycyl-tRNA aminoacylation SubClassOf glycyl-tRNA aminoacylation
mitochondrial glycyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for mitochondrial protein translation

Added

mitochondrial glycyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
mitochondrial glycyl-tRNA aminoacylation term replaced by tRNA aminoacylation for mitochondrial protein translation
mitochondrial glycyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial glycyl-tRNA aminoacylation deprecated true
mitochondrial glycyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004820 glycine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0070127 tRNA aminoacylation for mitochondrial protein translation.”
mitochondrial glycyl-tRNA aminoacylation label “obsolete mitochondrial glycyl-tRNA aminoacylation”

mitochondrial histidyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0070151`

Removed

mitochondrial histidyl-tRNA aminoacylation definition “The process of coupling histidine to histidyl-tRNA in a mitochondrion, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial histidyl-tRNA aminoacylation label “mitochondrial histidyl-tRNA aminoacylation”
mitochondrial histidyl-tRNA aminoacylation EquivalentTo histidyl-tRNA aminoacylation and (occurs in some mitochondrion)
mitochondrial histidyl-tRNA aminoacylation SubClassOf histidyl-tRNA aminoacylation
mitochondrial histidyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for mitochondrial protein translation

Added

mitochondrial histidyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
mitochondrial histidyl-tRNA aminoacylation term replaced by tRNA aminoacylation for mitochondrial protein translation
mitochondrial histidyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling histidine to histidyl-tRNA in a mitochondrion, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial histidyl-tRNA aminoacylation deprecated true
mitochondrial histidyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004821 histidine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0070127 tRNA aminoacylation for mitochondrial protein translation.”
mitochondrial histidyl-tRNA aminoacylation label “obsolete mitochondrial histidyl-tRNA aminoacylation”

mitochondrial intermembrane space chaperone complex `http://purl.obolibrary.org/obo/GO_0042719`

Removed

mitochondrial intermembrane space chaperone complex has_narrow_synonym “Tim8-Tim13 complex”
mitochondrial intermembrane space chaperone complex has_narrow_synonym “Tim9-Tim10 complex”

Added

mitochondrial intermembrane space chaperone complex term tracker item “https://github.com/geneontology/go-ontology/issues/32408”^^anyURI

mitochondrial isoleucyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0070152`

Removed

mitochondrial isoleucyl-tRNA aminoacylation definition “The process of coupling isoleucine to isoleucyl-tRNA in a mitochondrion, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial isoleucyl-tRNA aminoacylation label “mitochondrial isoleucyl-tRNA aminoacylation”
mitochondrial isoleucyl-tRNA aminoacylation EquivalentTo isoleucyl-tRNA aminoacylation and (occurs in some mitochondrion)
mitochondrial isoleucyl-tRNA aminoacylation SubClassOf isoleucyl-tRNA aminoacylation
mitochondrial isoleucyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for mitochondrial protein translation

Added

mitochondrial isoleucyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
mitochondrial isoleucyl-tRNA aminoacylation term replaced by tRNA aminoacylation for mitochondrial protein translation
mitochondrial isoleucyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling isoleucine to isoleucyl-tRNA in a mitochondrion, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial isoleucyl-tRNA aminoacylation deprecated true
mitochondrial isoleucyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004822 isoleucine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0070127 tRNA aminoacylation for mitochondrial protein translation.”
mitochondrial isoleucyl-tRNA aminoacylation label “obsolete mitochondrial isoleucyl-tRNA aminoacylation”

mitochondrial leucyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0070153`

Removed

mitochondrial leucyl-tRNA aminoacylation definition “The process of coupling leucine to leucyl-tRNA in a mitochondrion, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial leucyl-tRNA aminoacylation label “mitochondrial leucyl-tRNA aminoacylation”
mitochondrial leucyl-tRNA aminoacylation EquivalentTo leucyl-tRNA aminoacylation and (occurs in some mitochondrion)
mitochondrial leucyl-tRNA aminoacylation SubClassOf leucyl-tRNA aminoacylation
mitochondrial leucyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for mitochondrial protein translation

Added

mitochondrial leucyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
mitochondrial leucyl-tRNA aminoacylation term replaced by tRNA aminoacylation for mitochondrial protein translation
mitochondrial leucyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling leucine to leucyl-tRNA in a mitochondrion, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial leucyl-tRNA aminoacylation deprecated true
mitochondrial leucyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004823 leucine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0070127 tRNA aminoacylation for mitochondrial protein translation.”
mitochondrial leucyl-tRNA aminoacylation label “obsolete mitochondrial leucyl-tRNA aminoacylation”

mitochondrial lysyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0070154`

Removed

mitochondrial lysyl-tRNA aminoacylation definition “The process of coupling lysine to lysyl-tRNA in a mitochondrion, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial lysyl-tRNA aminoacylation label “mitochondrial lysyl-tRNA aminoacylation”
mitochondrial lysyl-tRNA aminoacylation EquivalentTo lysyl-tRNA aminoacylation and (occurs in some mitochondrion)
mitochondrial lysyl-tRNA aminoacylation SubClassOf lysyl-tRNA aminoacylation
mitochondrial lysyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for mitochondrial protein translation

Added

mitochondrial lysyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
mitochondrial lysyl-tRNA aminoacylation term replaced by tRNA aminoacylation for mitochondrial protein translation
mitochondrial lysyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling lysine to lysyl-tRNA in a mitochondrion, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial lysyl-tRNA aminoacylation deprecated true
mitochondrial lysyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004824 lysine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0070127 tRNA aminoacylation for mitochondrial protein translation.”
mitochondrial lysyl-tRNA aminoacylation label “obsolete mitochondrial lysyl-tRNA aminoacylation”

mitochondrial membrane organization `http://purl.obolibrary.org/obo/GO_0007006`

Removed

mitochondrial membrane organization EquivalentTo membrane organization and (occurs in some mitochondrion)
mitochondrial membrane organization SubClassOf mitochondrion organization
mitochondrial membrane organization SubClassOf occurs in some mitochondrion

Added

mitochondrial membrane organization term tracker item “https://github.com/geneontology/go-ontology/issues/32356”^^anyURI
mitochondrial membrane organization SubClassOf part of some mitochondrion organization

mitochondrial methionyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0070155`

Removed

mitochondrial methionyl-tRNA aminoacylation definition “The process of coupling methionine to methionyl-tRNA in a mitochondrion, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial methionyl-tRNA aminoacylation label “mitochondrial methionyl-tRNA aminoacylation”
mitochondrial methionyl-tRNA aminoacylation EquivalentTo methionyl-tRNA aminoacylation and (occurs in some mitochondrion)
mitochondrial methionyl-tRNA aminoacylation SubClassOf methionyl-tRNA aminoacylation
mitochondrial methionyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for mitochondrial protein translation

Added

mitochondrial methionyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
mitochondrial methionyl-tRNA aminoacylation term replaced by tRNA aminoacylation for mitochondrial protein translation
mitochondrial methionyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling methionine to methionyl-tRNA in a mitochondrion, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial methionyl-tRNA aminoacylation deprecated true
mitochondrial methionyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004825 methionine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0070127 tRNA aminoacylation for mitochondrial protein translation.”
mitochondrial methionyl-tRNA aminoacylation label “obsolete mitochondrial methionyl-tRNA aminoacylation”

mitochondrial phenylalanyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0070156`

Removed

mitochondrial phenylalanyl-tRNA aminoacylation definition “The process of coupling phenylalanine to phenylalanyl-tRNA in a mitochondrion, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial phenylalanyl-tRNA aminoacylation label “mitochondrial phenylalanyl-tRNA aminoacylation”
mitochondrial phenylalanyl-tRNA aminoacylation EquivalentTo phenylalanyl-tRNA aminoacylation and (occurs in some mitochondrion)
mitochondrial phenylalanyl-tRNA aminoacylation SubClassOf phenylalanyl-tRNA aminoacylation
mitochondrial phenylalanyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for mitochondrial protein translation

Added

mitochondrial phenylalanyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
mitochondrial phenylalanyl-tRNA aminoacylation term replaced by tRNA aminoacylation for mitochondrial protein translation
mitochondrial phenylalanyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling phenylalanine to phenylalanyl-tRNA in a mitochondrion, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial phenylalanyl-tRNA aminoacylation deprecated true
mitochondrial phenylalanyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004826 phenylalanine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0070127 tRNA aminoacylation for mitochondrial protein translation.”
mitochondrial phenylalanyl-tRNA aminoacylation label “obsolete mitochondrial phenylalanyl-tRNA aminoacylation”

mitochondrial prolyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0070157`

Removed

mitochondrial prolyl-tRNA aminoacylation definition “The process of coupling proline to prolyl-tRNA in a mitochondrion, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial prolyl-tRNA aminoacylation label “mitochondrial prolyl-tRNA aminoacylation”
mitochondrial prolyl-tRNA aminoacylation EquivalentTo prolyl-tRNA aminoacylation and (occurs in some mitochondrion)
mitochondrial prolyl-tRNA aminoacylation SubClassOf prolyl-tRNA aminoacylation
mitochondrial prolyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for mitochondrial protein translation

Added

mitochondrial prolyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
mitochondrial prolyl-tRNA aminoacylation term replaced by tRNA aminoacylation for mitochondrial protein translation
mitochondrial prolyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling proline to prolyl-tRNA in a mitochondrion, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial prolyl-tRNA aminoacylation deprecated true
mitochondrial prolyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004827 proline-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0070127 tRNA aminoacylation for mitochondrial protein translation.”
mitochondrial prolyl-tRNA aminoacylation label “obsolete mitochondrial prolyl-tRNA aminoacylation”

mitochondrial protein quality control `http://purl.obolibrary.org/obo/GO_0141164`

Removed

mitochondrial protein quality control definition “The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the mitochondrion, which are targeted for degradation.”
- database_cross_reference “PMID:38280230”

Added

mitochondrial protein quality control term tracker item “https://github.com/geneontology/go-ontology/issues/32546”^^anyURI
mitochondrial protein quality control definition “The chemical reactions and pathways resulting in the breakdown of aberrant proteins in the mitochondrion which are targeted for degradation, including misfolded proteins and orphan subunits that fail to assemble into their cognate complex.”
- database_cross_reference “PMID:38280230”
- database_cross_reference “PMID:7623837”
- database_cross_reference “PMID:34436539”
mitochondrial protein quality control SubClassOf protein catabolic process

mitochondrial protein-transporting ATPase activity `http://purl.obolibrary.org/obo/GO_0008566`

Removed

mitochondrial protein-transporting ATPase activity definition “Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex.”
- database_cross_reference “EC:7.4.2.3”
mitochondrial protein-transporting ATPase activity comment “See also the cellular component term ‘mitochondrial inner membrane presequence translocase complex ; GO:0005744’.”
mitochondrial protein-transporting ATPase activity label “mitochondrial protein-transporting ATPase activity”
mitochondrial protein-transporting ATPase activity EquivalentTo protein-transporting ATPase activity and (occurs in some mitochondrion)
mitochondrial protein-transporting ATPase activity SubClassOf protein-transporting ATPase activity
mitochondrial protein-transporting ATPase activity SubClassOf occurs in some mitochondrion

Added

mitochondrial protein-transporting ATPase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32393”^^anyURI
mitochondrial protein-transporting ATPase activity definition “OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex.”
- database_cross_reference “EC:7.4.2.3”
mitochondrial protein-transporting ATPase activity deprecated true
mitochondrial protein-transporting ATPase activity comment “The reason for obsoletion is that the term is not clearly defined and usage has been inconsistent.”
mitochondrial protein-transporting ATPase activity label “obsolete mitochondrial protein-transporting ATPase activity”

mitochondrial seryl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0070158`

Removed

mitochondrial seryl-tRNA aminoacylation definition “The process of coupling serine to seryl-tRNA in a mitochondrion, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial seryl-tRNA aminoacylation label “mitochondrial seryl-tRNA aminoacylation”
mitochondrial seryl-tRNA aminoacylation EquivalentTo seryl-tRNA aminoacylation and (occurs in some mitochondrion)
mitochondrial seryl-tRNA aminoacylation SubClassOf seryl-tRNA aminoacylation
mitochondrial seryl-tRNA aminoacylation SubClassOf tRNA aminoacylation for mitochondrial protein translation

Added

mitochondrial seryl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
mitochondrial seryl-tRNA aminoacylation term replaced by tRNA aminoacylation for mitochondrial protein translation
mitochondrial seryl-tRNA aminoacylation definition “OBSOLETE. The process of coupling serine to seryl-tRNA in a mitochondrion, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial seryl-tRNA aminoacylation deprecated true
mitochondrial seryl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004828 serine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0070127 tRNA aminoacylation for mitochondrial protein translation.”
mitochondrial seryl-tRNA aminoacylation label “obsolete mitochondrial seryl-tRNA aminoacylation”

mitochondrial threonyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0070159`

Removed

mitochondrial threonyl-tRNA aminoacylation definition “The process of coupling threonine to threonyl-tRNA in a mitochondrion, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial threonyl-tRNA aminoacylation label “mitochondrial threonyl-tRNA aminoacylation”
mitochondrial threonyl-tRNA aminoacylation EquivalentTo threonyl-tRNA aminoacylation and (occurs in some mitochondrion)
mitochondrial threonyl-tRNA aminoacylation SubClassOf threonyl-tRNA aminoacylation
mitochondrial threonyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for mitochondrial protein translation

Added

mitochondrial threonyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
mitochondrial threonyl-tRNA aminoacylation term replaced by tRNA aminoacylation for mitochondrial protein translation
mitochondrial threonyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling threonine to threonyl-tRNA in a mitochondrion, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial threonyl-tRNA aminoacylation deprecated true
mitochondrial threonyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004829 threonine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0070127 tRNA aminoacylation for mitochondrial protein translation.”
mitochondrial threonyl-tRNA aminoacylation label “obsolete mitochondrial threonyl-tRNA aminoacylation”

mitochondrial tryptophanyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0070183`

Removed

mitochondrial tryptophanyl-tRNA aminoacylation definition “The process of coupling tryptophan to tryptophanyl-tRNA in a mitochondrion, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial tryptophanyl-tRNA aminoacylation label “mitochondrial tryptophanyl-tRNA aminoacylation”
mitochondrial tryptophanyl-tRNA aminoacylation EquivalentTo tryptophanyl-tRNA aminoacylation and (occurs in some mitochondrion)
mitochondrial tryptophanyl-tRNA aminoacylation SubClassOf tryptophanyl-tRNA aminoacylation
mitochondrial tryptophanyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for mitochondrial protein translation

Added

mitochondrial tryptophanyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
mitochondrial tryptophanyl-tRNA aminoacylation term replaced by tRNA aminoacylation for mitochondrial protein translation
mitochondrial tryptophanyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling tryptophan to tryptophanyl-tRNA in a mitochondrion, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial tryptophanyl-tRNA aminoacylation deprecated true
mitochondrial tryptophanyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004830 tryptophan-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0070127 tRNA aminoacylation for mitochondrial protein translation.”
mitochondrial tryptophanyl-tRNA aminoacylation label “obsolete mitochondrial tryptophanyl-tRNA aminoacylation”

mitochondrial tyrosyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0070184`

Removed

mitochondrial tyrosyl-tRNA aminoacylation definition “The process of coupling tyrosine to tyrosyl-tRNA in a mitochondrion, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial tyrosyl-tRNA aminoacylation label “mitochondrial tyrosyl-tRNA aminoacylation”
mitochondrial tyrosyl-tRNA aminoacylation EquivalentTo tyrosyl-tRNA aminoacylation and (occurs in some mitochondrion)
mitochondrial tyrosyl-tRNA aminoacylation SubClassOf tyrosyl-tRNA aminoacylation
mitochondrial tyrosyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for mitochondrial protein translation

Added

mitochondrial tyrosyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
mitochondrial tyrosyl-tRNA aminoacylation term replaced by tRNA aminoacylation for mitochondrial protein translation
mitochondrial tyrosyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling tyrosine to tyrosyl-tRNA in a mitochondrion, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial tyrosyl-tRNA aminoacylation deprecated true
mitochondrial tyrosyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004831 tyrosine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0070127 tRNA aminoacylation for mitochondrial protein translation.”
mitochondrial tyrosyl-tRNA aminoacylation label “obsolete mitochondrial tyrosyl-tRNA aminoacylation”

mitochondrial valyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0070185`

Removed

mitochondrial valyl-tRNA aminoacylation definition “The process of coupling valine to valyl-tRNA in a mitochondrion, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial valyl-tRNA aminoacylation label “mitochondrial valyl-tRNA aminoacylation”
mitochondrial valyl-tRNA aminoacylation EquivalentTo valyl-tRNA aminoacylation and (occurs in some mitochondrion)
mitochondrial valyl-tRNA aminoacylation SubClassOf valyl-tRNA aminoacylation
mitochondrial valyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for mitochondrial protein translation

Added

mitochondrial valyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
mitochondrial valyl-tRNA aminoacylation term replaced by tRNA aminoacylation for mitochondrial protein translation
mitochondrial valyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling valine to valyl-tRNA in a mitochondrion, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
mitochondrial valyl-tRNA aminoacylation deprecated true
mitochondrial valyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004832 valine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0070127 tRNA aminoacylation for mitochondrial protein translation.”
mitochondrial valyl-tRNA aminoacylation label “obsolete mitochondrial valyl-tRNA aminoacylation”

momilactone-A synthase [NAD(P)H] activity `http://purl.obolibrary.org/obo/GO_0102960`

Removed

momilactone-A synthase [NAD(P)H] activity exactMatch 25363

mycoredoxin-dependent peroxiredoxin activity `http://purl.obolibrary.org/obo/GO_7770100`

Added

Class: mycoredoxin-dependent peroxiredoxin activity
mycoredoxin-dependent peroxiredoxin activity term tracker item “https://github.com/geneontology/go-ontology/issues/32405”^^anyURI
mycoredoxin-dependent peroxiredoxin activity created by “ai4c-agent”
mycoredoxin-dependent peroxiredoxin activity creation date “2026-08-04T17:43:33Z”
mycoredoxin-dependent peroxiredoxin activity database_cross_reference “EC:1.11.1.29”
mycoredoxin-dependent peroxiredoxin activity database_cross_reference “RHEA:62640”
mycoredoxin-dependent peroxiredoxin activity has_obo_namespace “molecular_function”
mycoredoxin-dependent peroxiredoxin activity has_related_synonym “thiol peroxidase activity”
mycoredoxin-dependent peroxiredoxin activity id “GO:7770100”
mycoredoxin-dependent peroxiredoxin activity exactMatch 1.11.1.29
mycoredoxin-dependent peroxiredoxin activity exactMatch 62640
mycoredoxin-dependent peroxiredoxin activity definition “Catalysis of the reaction: [mycoredoxin]-dithiol + a hydroperoxide = [mycoredoxin]-disulfide + an alcohol + H2O.”
- database_cross_reference “RHEA:62640”
- database_cross_reference “PMID:19737009”
- database_cross_reference “PMID:24379404”
mycoredoxin-dependent peroxiredoxin activity label “mycoredoxin-dependent peroxiredoxin activity”
mycoredoxin-dependent peroxiredoxin activity SubClassOf peroxiredoxin activity

myeloid dendritic cell cytokine production `http://purl.obolibrary.org/obo/GO_0002372`

Removed

myeloid dendritic cell cytokine production comment “Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the ‘regulation’ children terms.”

Added

myeloid dendritic cell cytokine production term tracker item “https://github.com/geneontology/go-ontology/issues/20574”^^anyURI
myeloid dendritic cell cytokine production comment “Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the ‘regulation’ children terms. The is_a link to GO:0002444 is asserted rather than inferred because GO:0002444 has no logical definition; it must be maintained by hand (see #20574).”

myeloid leukocyte mediated immunity `http://purl.obolibrary.org/obo/GO_0002444`

Added

myeloid leukocyte mediated immunity term tracker item “https://github.com/geneontology/go-ontology/issues/20574”^^anyURI
myeloid leukocyte mediated immunity comment “This term intentionally has no logical definition: it is a grouping class covering everything myeloid leukocytes do immunologically, and no relation in GO expresses that role as necessary and sufficient conditions. Subclasses must be asserted by hand (see #20574).”

myo-inositol export across plasma membrane `http://purl.obolibrary.org/obo/GO_7770109`

Added

Class: myo-inositol export across plasma membrane
myo-inositol export across plasma membrane term tracker item “https://github.com/geneontology/go-ontology/issues/32460”^^anyURI
myo-inositol export across plasma membrane created by “ai4c-agent”
myo-inositol export across plasma membrane creation date “2026-08-14T19:33:20Z”
myo-inositol export across plasma membrane has_broad_synonym “inositol export”
myo-inositol export across plasma membrane has_broad_synonym “myo-inositol export”
myo-inositol export across plasma membrane has_exact_synonym “myo-inositol export from cell”
myo-inositol export across plasma membrane has_obo_namespace “biological_process”
myo-inositol export across plasma membrane id “GO:7770109”
myo-inositol export across plasma membrane definition “The directed movement of myo-inositol from inside of a cell, across the plasma membrane and into the extracellular region.”
- database_cross_reference “PMID:42567923”
myo-inositol export across plasma membrane label “myo-inositol export across plasma membrane”
myo-inositol export across plasma membrane SubClassOf polyol transmembrane transport
myo-inositol export across plasma membrane SubClassOf myo-inositol transport
myo-inositol export across plasma membrane SubClassOf export across plasma membrane

negative regluation of nuclear-transribed mRNA catabolic process, no-go decay `http://purl.obolibrary.org/obo/GO_0170075`

Removed

negative regluation of nuclear-transribed mRNA catabolic process, no-go decay label “negative regluation of nuclear-transribed mRNA catabolic process, no-go decay”

Added

negative regluation of nuclear-transribed mRNA catabolic process, no-go decay label “negative regulation of nuclear-transcribed mRNA catabolic process, no-go decay”

negative regulation of ERAD pathway `http://purl.obolibrary.org/obo/GO_1904293`

Removed

negative regulation of ERAD pathway SubClassOf negative regulation of response to endoplasmic reticulum stress

negative regulation of coenzyme A biosynthetic process `http://purl.obolibrary.org/obo/GO_0170077`

Added

Class: negative regulation of coenzyme A biosynthetic process
negative regulation of coenzyme A biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/32390”^^anyURI
negative regulation of coenzyme A biosynthetic process created by “ew”
negative regulation of coenzyme A biosynthetic process creation date “2026-08-10T18:46:59Z”
negative regulation of coenzyme A biosynthetic process has_obo_namespace “biological_process”
negative regulation of coenzyme A biosynthetic process id “GO:0170077”
negative regulation of coenzyme A biosynthetic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of coenzyme A.”
- database_cross_reference “PMID:42000723”
negative regulation of coenzyme A biosynthetic process label “negative regulation of coenzyme A biosynthetic process”
negative regulation of coenzyme A biosynthetic process SubClassOf regulation of coenzyme A biosynthetic process

negative regulation of cristae formation `http://purl.obolibrary.org/obo/GO_1903851`

Removed

negative regulation of cristae formation SubClassOf negative regulation of organelle organization

Added

negative regulation of cristae formation SubClassOf negative regulation of cellular component organization

negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape `http://purl.obolibrary.org/obo/GO_2000750`

Removed

negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape definition “Any process that stops, prevents or reduces the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape.”
- database_cross_reference “GOC:mah”
negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape label “negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape”
negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape EquivalentTo biological regulation and (negatively regulates some establishment or maintenance of bipolar cell polarity regulating cell shape)
negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape SubClassOf regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape SubClassOf negative regulation of establishment or maintenance of cell polarity regulating cell shape
negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape SubClassOf negatively regulates some establishment or maintenance of bipolar cell polarity regulating cell shape

Added

negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape term tracker item “https://github.com/geneontology/go-ontology/issues/21217”^^anyURI
negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape term replaced by establishment or maintenance of bipolar cell polarity
negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape definition “OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape.”
- database_cross_reference “GOC:mah”
negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape deprecated true
negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape comment “The reason for obsoletion is that this term was made in error.”
negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape label “obsolete negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape”

negative regulation of glycolytic process `http://purl.obolibrary.org/obo/GO_0045820`

Removed

negative regulation of glycolytic process label “negative regulation of glycolytic process”

Added

negative regulation of glycolytic process has_exact_synonym “negative regulation of glycolytic process”
negative regulation of glycolytic process label “negative regulation of glycolysis”

negative regulation of glycolytic process through fructose-6-phosphate `http://purl.obolibrary.org/obo/GO_1904539`

Removed

negative regulation of glycolytic process through fructose-6-phosphate definition “Any process that stops, prevents or reduces the frequency, rate or extent of glycolytic process through fructose-6-phosphate.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “ISBN:0879010479”
- database_cross_reference “ISBN:0201090910”
- database_cross_reference “GO_REF:0000058”
negative regulation of glycolytic process through fructose-6-phosphate label “negative regulation of glycolytic process through fructose-6-phosphate”
negative regulation of glycolytic process through fructose-6-phosphate EquivalentTo biological regulation and (negatively regulates some glycolytic process through fructose-6-phosphate)
negative regulation of glycolytic process through fructose-6-phosphate SubClassOf negative regulation of glycolytic process
negative regulation of glycolytic process through fructose-6-phosphate SubClassOf negatively regulates some glycolytic process through fructose-6-phosphate

Added

negative regulation of glycolytic process through fructose-6-phosphate term tracker item “https://github.com/geneontology/go-ontology/issues/32471”^^anyURI
negative regulation of glycolytic process through fructose-6-phosphate term replaced by negative regulation of glycolytic process
negative regulation of glycolytic process through fructose-6-phosphate definition “OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of glycolytic process through fructose-6-phosphate.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “ISBN:0879010479”
- database_cross_reference “ISBN:0201090910”
- database_cross_reference “GO_REF:0000058”
negative regulation of glycolytic process through fructose-6-phosphate deprecated true
negative regulation of glycolytic process through fructose-6-phosphate comment “The reason for obsoletion is that this term represents a GO-CAM model.”
negative regulation of glycolytic process through fructose-6-phosphate label “obsolete negative regulation of glycolytic process through fructose-6-phosphate”

negative regulation of maintenance of bipolar cell polarity regulating cell shape `http://purl.obolibrary.org/obo/GO_0061362`

Removed

negative regulation of maintenance of bipolar cell polarity regulating cell shape definition “Any process that decreases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape.”
- database_cross_reference “GOC:dph”
negative regulation of maintenance of bipolar cell polarity regulating cell shape label “negative regulation of maintenance of bipolar cell polarity regulating cell shape”
negative regulation of maintenance of bipolar cell polarity regulating cell shape SubClassOf regulation of maintenance of bipolar cell polarity regulating cell shape
negative regulation of maintenance of bipolar cell polarity regulating cell shape SubClassOf negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
negative regulation of maintenance of bipolar cell polarity regulating cell shape SubClassOf negatively regulates some maintenance of bipolar cell polarity regulating cell shape

Added

negative regulation of maintenance of bipolar cell polarity regulating cell shape term tracker item “https://github.com/geneontology/go-ontology/issues/21217”^^anyURI
negative regulation of maintenance of bipolar cell polarity regulating cell shape term replaced by establishment or maintenance of bipolar cell polarity
negative regulation of maintenance of bipolar cell polarity regulating cell shape definition “OBSOLETE. Any process that decreases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape.”
- database_cross_reference “GOC:dph”
negative regulation of maintenance of bipolar cell polarity regulating cell shape deprecated true
negative regulation of maintenance of bipolar cell polarity regulating cell shape comment “The reason for obsoletion is that this term was made in error.”
negative regulation of maintenance of bipolar cell polarity regulating cell shape label “obsolete negative regulation of maintenance of bipolar cell polarity regulating cell shape”

negative regulation of mitochondrial respiratory chain complex I assembly `http://purl.obolibrary.org/obo/GO_7770120`

Added

Class: negative regulation of mitochondrial respiratory chain complex I assembly
negative regulation of mitochondrial respiratory chain complex I assembly term tracker item “https://github.com/geneontology/go-ontology/issues/32577”^^anyURI
negative regulation of mitochondrial respiratory chain complex I assembly created by “ai4c-agent”
negative regulation of mitochondrial respiratory chain complex I assembly creation date “2026-09-11T00:23:26Z”
negative regulation of mitochondrial respiratory chain complex I assembly has_obo_namespace “biological_process”
negative regulation of mitochondrial respiratory chain complex I assembly id “GO:7770120”
negative regulation of mitochondrial respiratory chain complex I assembly definition “Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial respiratory chain complex I assembly.”
- database_cross_reference “PMID:42361792”
negative regulation of mitochondrial respiratory chain complex I assembly label “negative regulation of mitochondrial respiratory chain complex I assembly”
negative regulation of mitochondrial respiratory chain complex I assembly EquivalentTo biological regulation and (negatively regulates some mitochondrial respiratory chain complex I assembly)
negative regulation of mitochondrial respiratory chain complex I assembly SubClassOf negative regulation of protein-containing complex assembly
negative regulation of mitochondrial respiratory chain complex I assembly SubClassOf regulation of mitochondrial respiratory chain complex I assembly
negative regulation of mitochondrial respiratory chain complex I assembly SubClassOf negatively regulates some mitochondrial respiratory chain complex I assembly

negative regulation of protein localization to mitochondrion `http://purl.obolibrary.org/obo/GO_1903748`

Removed

negative regulation of protein localization to mitochondrion term tracker item “https://github.com/geneontology/go-ontology/issues/30349”^^anyURI
negative regulation of protein localization to mitochondrion definition “Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to mitochondrion.”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:16857185”
- database_cross_reference “GO_REF:0000058”
negative regulation of protein localization to mitochondrion label “negative regulation of protein localization to mitochondrion”
negative regulation of protein localization to mitochondrion EquivalentTo biological regulation and (negatively regulates some protein localization to mitochondrion)
negative regulation of protein localization to mitochondrion SubClassOf regulation of protein localization to mitochondrion
negative regulation of protein localization to mitochondrion SubClassOf negative regulation of protein localization
negative regulation of protein localization to mitochondrion SubClassOf negatively regulates some protein localization to mitochondrion

Added

negative regulation of protein localization to mitochondrion term tracker item “https://github.com/geneontology/go-ontology/issues/32107”^^anyURI
negative regulation of protein localization to mitochondrion definition “OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to mitochondrion.”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:16857185”
- database_cross_reference “GO_REF:0000058”
negative regulation of protein localization to mitochondrion deprecated true
negative regulation of protein localization to mitochondrion comment “The reason for obsoletion is that this term represents a phenotype and was added in error. Consider annotating to negative regulation of the specific process being regulated (e.g. negative regulation of mitophagy) or to a specific mitochondrial protein import pathway; if the underlying evidence is a readout or a phenotype, or the mechanism is unclear, consider removal rather than re-annotation.”
negative regulation of protein localization to mitochondrion label “obsolete negative regulation of protein localization to mitochondrion”

negative regulation of retrograde protein transport, ER to cytosol `http://purl.obolibrary.org/obo/GO_1904153`

Removed

negative regulation of retrograde protein transport, ER to cytosol definition “Any process that stops, prevents or reduces the frequency, rate or extent of retrograde protein transport, ER to cytosol.”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:PARL”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:18555783”
- database_cross_reference “GO_REF:0000058”
negative regulation of retrograde protein transport, ER to cytosol label “negative regulation of retrograde protein transport, ER to cytosol”
negative regulation of retrograde protein transport, ER to cytosol EquivalentTo biological regulation and (negatively regulates some retrograde protein transport, ER to cytosol)
negative regulation of retrograde protein transport, ER to cytosol SubClassOf negative regulation of protein transport
negative regulation of retrograde protein transport, ER to cytosol SubClassOf regulation of retrograde protein transport, ER to cytosol
negative regulation of retrograde protein transport, ER to cytosol SubClassOf negatively regulates some retrograde protein transport, ER to cytosol

Added

negative regulation of retrograde protein transport, ER to cytosol term tracker item “https://github.com/geneontology/go-ontology/issues/32525”^^anyURI
negative regulation of retrograde protein transport, ER to cytosol term replaced by negative regulation of ERAD pathway
negative regulation of retrograde protein transport, ER to cytosol definition “OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of retrograde protein transport, ER to cytosol.”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:PARL”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:18555783”
- database_cross_reference “GO_REF:0000058”
negative regulation of retrograde protein transport, ER to cytosol deprecated true
negative regulation of retrograde protein transport, ER to cytosol comment “The reason for obsoletion is that the term is not clearly defined and usage has been inconsistent, the data from the paper for which the term was requested can be accurately described using reguation of ERAD pathway terms, and this term was added in error.”
negative regulation of retrograde protein transport, ER to cytosol label “obsolete negative regulation of retrograde protein transport, ER to cytosol”

negative regulation of transcription from RNA polymerase II promoter by glucose `http://purl.obolibrary.org/obo/GO_0061987`

Removed

negative regulation of transcription from RNA polymerase II promoter by glucose definition “Any process involving glucose that decreases the frequency, rate or extent or transcription from an RNA polymerase II promoter.”
- database_cross_reference “PMID:11875061”
negative regulation of transcription from RNA polymerase II promoter by glucose label “negative regulation of transcription from RNA polymerase II promoter by glucose”
negative regulation of transcription from RNA polymerase II promoter by glucose SubClassOf regulation of transcription from RNA polymerase II promoter by glucose
negative regulation of transcription from RNA polymerase II promoter by glucose SubClassOf negative regulation of transcription by glucose

Added

negative regulation of transcription from RNA polymerase II promoter by glucose term tracker item “https://github.com/geneontology/go-ontology/issues/21442”^^anyURI
negative regulation of transcription from RNA polymerase II promoter by glucose consider negative regulation of transcription by RNA polymerase II
negative regulation of transcription from RNA polymerase II promoter by glucose definition “OBSOLETE. Any process involving glucose that decreases the frequency, rate or extent or transcription from an RNA polymerase II promoter.”
- database_cross_reference “PMID:11875061”
negative regulation of transcription from RNA polymerase II promoter by glucose deprecated true
negative regulation of transcription from RNA polymerase II promoter by glucose comment “The reason for obsoletion is that these terms represent GO-CAM models.”
negative regulation of transcription from RNA polymerase II promoter by glucose label “obsolete negative regulation of transcription from RNA polymerase II promoter by glucose”

negative regulation of vesicle fusion with Golgi apparatus `http://purl.obolibrary.org/obo/GO_0106215`

Removed

negative regulation of vesicle fusion with Golgi apparatus definition “Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fustion with Golgi apparatus.”
- database_cross_reference “GOC:se”
- database_cross_reference “PMID:26195667”

Added

negative regulation of vesicle fusion with Golgi apparatus definition “Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fusion with Golgi apparatus.”
- database_cross_reference “GOC:se”
- database_cross_reference “PMID:26195667”

neurotransmitter receptor transport, postsynaptic endosome to lysosome `http://purl.obolibrary.org/obo/GO_0098943`

Removed

neurotransmitter receptor transport, postsynaptic endosome to lysosome definition “The directed movement of neurotransmitter receptor from the postsynaptic endosome in tranpsort vesicles to the lysosome for degradation.”
- database_cross_reference “GOC:dos”

Added

neurotransmitter receptor transport, postsynaptic endosome to lysosome definition “The directed movement of neurotransmitter receptor from the postsynaptic endosome in transport vesicles to the lysosome for degradation.”
- database_cross_reference “GOC:dos”

nitrate assimilation `http://purl.obolibrary.org/obo/GO_0042128`

Added

nitrate assimilation term tracker item “https://github.com/geneontology/go-ontology/issues/32376”^^anyURI
nitrate assimilation SubClassOf nutrient assimilation

noctua_allowed `http://purl.obolibrary.org/obo/go#noctua_allowed`

Added

AnnotationProperty: noctua_allowed
noctua_allowed comment “ChEBI terms allowed for use in Noctua, comprising the Rhea pH 7.3 subset and the GO ChEBI allow-list.”
noctua_allowed SubPropertyOf: subset_property

nuclear androgen receptor binding `http://purl.obolibrary.org/obo/GO_0050681`

Removed

nuclear androgen receptor binding definition “Binding to a nuclear androgen receptor.”
- database_cross_reference “GOC:ai”
nuclear androgen receptor binding label “nuclear androgen receptor binding”
nuclear androgen receptor binding SubClassOf nuclear receptor binding

Added

nuclear androgen receptor binding term tracker item “https://github.com/geneontology/go-ontology/issues/32475”^^anyURI
nuclear androgen receptor binding consider nuclear receptor binding
nuclear androgen receptor binding definition “OBSOLETE. Binding to a nuclear androgen receptor.”
- database_cross_reference “GOC:ai”
nuclear androgen receptor binding deprecated true
nuclear androgen receptor binding comment “The reason for obsoletion is that this term represents a gene product. Better to annotate with GO:0016922 nuclear receptor binding and androgen receptor as ‘has_input’.”
nuclear androgen receptor binding label “obsolete nuclear androgen receptor binding”

nuclear cortisol receptor binding `http://purl.obolibrary.org/obo/GO_0031961`

Removed

nuclear cortisol receptor binding definition “Binding to a nuclear cortisol receptor.”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:12511169”
nuclear cortisol receptor binding label “nuclear cortisol receptor binding”
nuclear cortisol receptor binding SubClassOf nuclear glucocorticoid receptor binding

Added

nuclear cortisol receptor binding term tracker item “https://github.com/geneontology/go-ontology/issues/32475”^^anyURI
nuclear cortisol receptor binding consider nuclear receptor binding
nuclear cortisol receptor binding definition “OBSOLETE. Binding to a nuclear cortisol receptor.”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:12511169”
nuclear cortisol receptor binding deprecated true
nuclear cortisol receptor binding comment “The reason for obsoletion is that this term represents a gene product. Better to annotate with GO:0016922 nuclear receptor binding and cortisol receptor as ‘has_input’.”
nuclear cortisol receptor binding label “obsolete nuclear cortisol receptor binding”

nuclear estrogen receptor binding `http://purl.obolibrary.org/obo/GO_0030331`

Removed

nuclear estrogen receptor binding definition “Binding to a nuclear estrogen receptor.”
- database_cross_reference “GOC:ai”
nuclear estrogen receptor binding label “nuclear estrogen receptor binding”
nuclear estrogen receptor binding SubClassOf nuclear receptor binding

Added

nuclear estrogen receptor binding term tracker item “https://github.com/geneontology/go-ontology/issues/32475”^^anyURI
nuclear estrogen receptor binding consider nuclear receptor binding
nuclear estrogen receptor binding definition “OBSOLETE. Binding to a nuclear estrogen receptor.”
- database_cross_reference “GOC:ai”
nuclear estrogen receptor binding deprecated true
nuclear estrogen receptor binding comment “The reason for obsoletion is that this term represents a gene product. Better to annotate with GO:0016922 nuclear receptor binding and estrogen receptor as ‘has_input’.”
nuclear estrogen receptor binding label “obsolete nuclear estrogen receptor binding”

nuclear glucocorticoid receptor binding `http://purl.obolibrary.org/obo/GO_0035259`

Removed

nuclear glucocorticoid receptor binding definition “Binding to a nuclear glucocorticoid receptor.”
- database_cross_reference “GOC:bf”
nuclear glucocorticoid receptor binding label “nuclear glucocorticoid receptor binding”
nuclear glucocorticoid receptor binding SubClassOf nuclear receptor binding

Added

nuclear glucocorticoid receptor binding term tracker item “https://github.com/geneontology/go-ontology/issues/32475”^^anyURI
nuclear glucocorticoid receptor binding consider nuclear receptor binding
nuclear glucocorticoid receptor binding definition “OBSOLETE. Binding to a nuclear glucocorticoid receptor.”
- database_cross_reference “GOC:bf”
nuclear glucocorticoid receptor binding deprecated true
nuclear glucocorticoid receptor binding comment “The reason for obsoletion is that this term represents a gene product. Better to annotate with GO:0016922 nuclear receptor binding and glucocorticoid receptor as ‘has_input’.”
nuclear glucocorticoid receptor binding label “obsolete nuclear glucocorticoid receptor binding”

nuclear mineralocorticoid receptor binding `http://purl.obolibrary.org/obo/GO_0031962`

Removed

nuclear mineralocorticoid receptor binding definition “Binding to a nuclear mineralocorticoid receptor.”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:12511169”
nuclear mineralocorticoid receptor binding label “nuclear mineralocorticoid receptor binding”
nuclear mineralocorticoid receptor binding SubClassOf nuclear receptor binding

Added

nuclear mineralocorticoid receptor binding term tracker item “https://github.com/geneontology/go-ontology/issues/32475”^^anyURI
nuclear mineralocorticoid receptor binding consider nuclear receptor binding
nuclear mineralocorticoid receptor binding definition “OBSOLETE. Binding to a nuclear mineralocorticoid receptor.”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:12511169”
nuclear mineralocorticoid receptor binding deprecated true
nuclear mineralocorticoid receptor binding comment “The reason for obsoletion is that this term represents a gene product. Better to annotate with GO:0016922 nuclear receptor binding and mineralocorticoid receptor as ‘has_input’.”
nuclear mineralocorticoid receptor binding label “obsolete nuclear mineralocorticoid receptor binding”

nuclear progesterone receptor binding `http://purl.obolibrary.org/obo/GO_0033142`

Removed

nuclear progesterone receptor binding definition “Binding to a nuclear progesterone receptor.”
- database_cross_reference “GOC:mah”
nuclear progesterone receptor binding label “nuclear progesterone receptor binding”
nuclear progesterone receptor binding SubClassOf nuclear receptor binding

Added

nuclear progesterone receptor binding term tracker item “https://github.com/geneontology/go-ontology/issues/32475”^^anyURI
nuclear progesterone receptor binding consider nuclear receptor binding
nuclear progesterone receptor binding definition “OBSOLETE. Binding to a nuclear progesterone receptor.”
- database_cross_reference “GOC:mah”
nuclear progesterone receptor binding deprecated true
nuclear progesterone receptor binding comment “The reason for obsoletion is that this term represents a gene product. Better to annotate with GO:0016922 nuclear receptor binding and progesterone receptor as ‘has_input’.”
nuclear progesterone receptor binding label “obsolete nuclear progesterone receptor binding”

nuclear protein quality control by the ubiquitin-proteasome system `http://purl.obolibrary.org/obo/GO_0071630`

Removed

nuclear protein quality control by the ubiquitin-proteasome system SubClassOf part of some cellular response to misfolded protein

Added

nuclear protein quality control by the ubiquitin-proteasome system term tracker item “https://github.com/geneontology/go-ontology/issues/32546”^^anyURI

nuclear retinoic acid receptor binding `http://purl.obolibrary.org/obo/GO_0042974`

Removed

nuclear retinoic acid receptor binding definition “Binding to a nuclear retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:12476796”
nuclear retinoic acid receptor binding label “nuclear retinoic acid receptor binding”
nuclear retinoic acid receptor binding SubClassOf nuclear receptor binding

Added

nuclear retinoic acid receptor binding term tracker item “https://github.com/geneontology/go-ontology/issues/32475”^^anyURI
nuclear retinoic acid receptor binding consider nuclear receptor binding
nuclear retinoic acid receptor binding definition “OBSOLETE. Binding to a nuclear retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:12476796”
nuclear retinoic acid receptor binding deprecated true
nuclear retinoic acid receptor binding comment “The reason for obsoletion is that this term represents a gene product. Better to annotate with GO:0016922 nuclear receptor binding and retinoic acid receptor as ‘has_input’.”
nuclear retinoic acid receptor binding label “obsolete nuclear retinoic acid receptor binding”

nuclear retinoid X receptor binding `http://purl.obolibrary.org/obo/GO_0046965`

Removed

nuclear retinoid X receptor binding definition “Binding to a nuclear retinoid X receptor.”
- database_cross_reference “GOC:ai”
nuclear retinoid X receptor binding label “nuclear retinoid X receptor binding”
nuclear retinoid X receptor binding SubClassOf nuclear retinoic acid receptor binding

Added

nuclear retinoid X receptor binding term tracker item “https://github.com/geneontology/go-ontology/issues/32475”^^anyURI
nuclear retinoid X receptor binding consider nuclear receptor binding
nuclear retinoid X receptor binding definition “OBSOLETE. Binding to a nuclear retinoid X receptor.”
- database_cross_reference “GOC:ai”
nuclear retinoid X receptor binding deprecated true
nuclear retinoid X receptor binding comment “The reason for obsoletion is that this term represents a gene product. Better to annotate with GO:0016922 nuclear receptor binding and retinoid X receptor as ‘has_input’.”
nuclear retinoid X receptor binding label “obsolete nuclear retinoid X receptor binding”

nuclear thyroid hormone receptor binding `http://purl.obolibrary.org/obo/GO_0046966`

Removed

nuclear thyroid hormone receptor binding definition “Binding to a nuclear thyroid hormone receptor.”
- database_cross_reference “GOC:ai”
nuclear thyroid hormone receptor binding label “nuclear thyroid hormone receptor binding”
nuclear thyroid hormone receptor binding SubClassOf nuclear receptor binding

Added

nuclear thyroid hormone receptor binding term tracker item “https://github.com/geneontology/go-ontology/issues/32475”^^anyURI
nuclear thyroid hormone receptor binding consider nuclear receptor binding
nuclear thyroid hormone receptor binding definition “OBSOLETE. Binding to a nuclear thyroid hormone receptor.”
- database_cross_reference “GOC:ai”
nuclear thyroid hormone receptor binding deprecated true
nuclear thyroid hormone receptor binding comment “The reason for obsoletion is that this term represents a gene product. Better to annotate with GO:0016922 nuclear receptor binding and thyroid hormone receptor as ‘has_input’.”
nuclear thyroid hormone receptor binding label “obsolete nuclear thyroid hormone receptor binding”

nuclear vitamin D receptor binding `http://purl.obolibrary.org/obo/GO_0042809`

Removed

nuclear vitamin D receptor binding definition “Binding to a nuclear vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:12637589”
nuclear vitamin D receptor binding label “nuclear vitamin D receptor binding”
nuclear vitamin D receptor binding SubClassOf nuclear receptor binding

Added

nuclear vitamin D receptor binding term tracker item “https://github.com/geneontology/go-ontology/issues/32475”^^anyURI
nuclear vitamin D receptor binding consider nuclear receptor binding
nuclear vitamin D receptor binding definition “OBSOLETE. Binding to a nuclear vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:12637589”
nuclear vitamin D receptor binding deprecated true
nuclear vitamin D receptor binding comment “The reason for obsoletion is that this term represents a gene product. Better to annotate with GO:0016922 nuclear receptor binding and vitamin D3 receptor as ‘has_input’.”
nuclear vitamin D receptor binding label “obsolete nuclear vitamin D receptor binding”

nutrient assimilation `http://purl.obolibrary.org/obo/GO_7770097`

Added

Class: nutrient assimilation
nutrient assimilation term tracker item “https://github.com/geneontology/go-ontology/issues/32376”^^anyURI
nutrient assimilation created by “ai4c-agent”
nutrient assimilation creation date “2026-07-29T05:36:39Z”
nutrient assimilation has_exact_synonym “assimilation of nutrients”
nutrient assimilation has_obo_namespace “biological_process”
nutrient assimilation id “GO:7770097”
nutrient assimilation in_subset gocheck_do_not_annotate
nutrient assimilation definition “The chemical reactions and pathways by which a cell or organism takes up a nutrient from its environment and incorporates it into cellular constituents, characteristically converting a simple, usually inorganic, nutrient source such as nitrate, sulfate, ammonia or a one-carbon compound into organic constituents of the cell.”
- database_cross_reference “PMID:34973427”
- database_cross_reference “PMID:22103536”
- database_cross_reference “PMID:27572125”
nutrient assimilation label “nutrient assimilation”
nutrient assimilation SubClassOf metabolic process

obsolete carbon catabolite repression of transcription from RNA polymerase II promoter by galactose `http://purl.obolibrary.org/obo/GO_0000434`

Removed

obsolete carbon catabolite repression of transcription from RNA polymerase II promoter by galactose term tracker item “The reason for obsoletion is that these terms represent GO-CAM models.”^^anyURI

Added

obsolete carbon catabolite repression of transcription from RNA polymerase II promoter by galactose term tracker item “https://github.com/geneontology/go-ontology/issues/21442”^^anyURI
obsolete carbon catabolite repression of transcription from RNA polymerase II promoter by galactose consider negative regulation of transcription by RNA polymerase II

obsolete cyclic ADP-ribose hydrolase `http://purl.obolibrary.org/obo/GO_0061812`

Removed

obsolete cyclic ADP-ribose hydrolase term replaced by NAD+ nucleosidase activity, cyclic ADP-ribose generating
obsolete cyclic ADP-ribose hydrolase definition “OBSOLETE. Catalysis of the reaction: cyclic ADP-ribose + H20 = ADP-ribose (ADPR).”
- database_cross_reference “GOC:dph”
- database_cross_reference “PMID:11866528”
- database_cross_reference “GOC:PARL”
- database_cross_reference “GOC:pad”
obsolete cyclic ADP-ribose hydrolase deprecated true
obsolete cyclic ADP-ribose hydrolase comment “This term was obsoleted because it represents a step in a multi-step reaction.”
obsolete cyclic ADP-ribose hydrolase label “obsolete cyclic ADP-ribose hydrolase”

Added

obsolete cyclic ADP-ribose hydrolase term tracker item “https://github.com/geneontology/go-ontology/issues/32457”^^anyURI
obsolete cyclic ADP-ribose hydrolase database_cross_reference “RHEA:38615”
obsolete cyclic ADP-ribose hydrolase has_exact_synonym “cADPR hydrolase activity”
obsolete cyclic ADP-ribose hydrolase exactMatch 38615
obsolete cyclic ADP-ribose hydrolase definition “Catalysis of the reaction: cyclic ADP-beta-D-ribose + H2O = ADP-D-ribose.”
- database_cross_reference “PMID:42243876”
- database_cross_reference “RHEA:38615”
obsolete cyclic ADP-ribose hydrolase comment “Note that this term was reinstated from obsolete.”
obsolete cyclic ADP-ribose hydrolase label “cyclic ADP-ribose hydrolase activity”
obsolete cyclic ADP-ribose hydrolase SubClassOf hydrolase activity, hydrolyzing N-glycosyl compounds

obsolete diaminopimelate biosynthetic process `http://purl.obolibrary.org/obo/GO_0019877`

Removed

obsolete diaminopimelate biosynthetic process consider L-leucine biosynthetic process
obsolete diaminopimelate biosynthetic process comment “This term was obsoleted because it represents an intermediate in L-leucine biosynthesis.”

Added

obsolete diaminopimelate biosynthetic process consider L-lysine biosynthetic process
obsolete diaminopimelate biosynthetic process comment “This term was obsoleted because it represents an intermediate in L-lysine biosynthesis.”

obsolete envenomation resulting in occlusion of the pore of voltage-gated potassium channel `http://purl.obolibrary.org/obo/GO_0044564`

Removed

obsolete envenomation resulting in occlusion of the pore of voltage-gated potassium channel term replaced by venom-mediated inhibition of voltage-gated potassium channel activity

obsolete envenomation resulting in slowing of activation kinetics of voltage-gated potassium channel `http://purl.obolibrary.org/obo/GO_0044563`

Removed

obsolete envenomation resulting in slowing of activation kinetics of voltage-gated potassium channel term replaced by venom-mediated inhibition of voltage-gated potassium channel activity

obsolete establishment of central gap gene boundaries `http://purl.obolibrary.org/obo/GO_0007358`

Removed

obsolete establishment of central gap gene boundaries definition “OBSOLETE. Specification of the borders of central gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by knirps repression of Kruppel.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

obsolete establishment of central gap gene boundaries term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
obsolete establishment of central gap gene boundaries definition “OBSOLETE. Specification of the borders of central gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by knirps repression of Kruppel.”
- database_cross_reference “ISBN:0879694238”

obsolete establishment of posterior gap gene boundaries `http://purl.obolibrary.org/obo/GO_0007361`

Removed

obsolete establishment of posterior gap gene boundaries definition “OBSOLETE. Specification of the borders of posterior gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by hunchback and tailless repression of knirps.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

obsolete establishment of posterior gap gene boundaries definition “OBSOLETE. Specification of the borders of posterior gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by hunchback and tailless repression of knirps.”
- database_cross_reference “ISBN:0879694238”

obsolete establishment of terminal gap gene boundary `http://purl.obolibrary.org/obo/GO_0007364`

Removed

obsolete establishment of terminal gap gene boundary definition “OBSOLETE. Specification of the borders of terminal gap gene expression mediated largely by the effects of other gap genes.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

obsolete establishment of terminal gap gene boundary definition “OBSOLETE. Specification of the borders of terminal gap gene expression mediated largely by the effects of other gap genes.”
- database_cross_reference “ISBN:0879694238”

obsolete glycoprotein-specific chaperone activity `http://purl.obolibrary.org/obo/GO_0003759`

Added

obsolete glycoprotein-specific chaperone activity term tracker item “https://github.com/geneontology/go-ontology/issues/32494”^^anyURI

obsolete integral component of phagophore assembly site membrane `http://purl.obolibrary.org/obo/GO_0097634`

Removed

obsolete integral component of phagophore assembly site membrane term replaced by phagophore assembly site membrane

Added

obsolete integral component of phagophore assembly site membrane term replaced by phagophore membrane

obsolete intrinsic component of phagophore assembly site membrane `http://purl.obolibrary.org/obo/GO_0097633`

Removed

obsolete intrinsic component of phagophore assembly site membrane term replaced by phagophore assembly site membrane

Added

obsolete intrinsic component of phagophore assembly site membrane term replaced by phagophore membrane

obsolete lectin-type holdase activity `http://purl.obolibrary.org/obo/GO_7770116`

Added

Class: obsolete lectin-type holdase activity
obsolete lectin-type holdase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32494”^^anyURI
obsolete lectin-type holdase activity term replaced by unfolded protein holdase activity
obsolete lectin-type holdase activity created by “ai4c-agent”
obsolete lectin-type holdase activity creation date “2026-08-26T21:57:40Z”
obsolete lectin-type holdase activity has_exact_synonym “carbohydrate-binding holdase”
obsolete lectin-type holdase activity has_obo_namespace “molecular_function”
obsolete lectin-type holdase activity has_related_synonym “lectin chaperone”
obsolete lectin-type holdase activity id “GO:7770116”
obsolete lectin-type holdase activity definition “OBSOLETE. A holdase activity that additionally recognizes a specific glycan structure on a protein via a lectin domain, and prevents aggregation of the protein until it is correctly folded.”
- database_cross_reference “PMID:16467570”
obsolete lectin-type holdase activity deprecated true
obsolete lectin-type holdase activity comment “The reason for obsoletion is that this term was added in error.”
obsolete lectin-type holdase activity label “obsolete lectin-type holdase activity”

obsolete ligand-dependent thyroid hormone receptor interactor activity `http://purl.obolibrary.org/obo/GO_0016923`

Removed

obsolete ligand-dependent thyroid hormone receptor interactor activity consider nuclear thyroid hormone receptor binding

Added

obsolete ligand-dependent thyroid hormone receptor interactor activity term tracker item “https://github.com/geneontology/go-ontology/issues/32475”^^anyURI
obsolete ligand-dependent thyroid hormone receptor interactor activity consider nuclear receptor binding

obsolete negative regulation of protein processing involved in protein targeting to mitochondrion `http://purl.obolibrary.org/obo/GO_1903217`

Removed

obsolete negative regulation of protein processing involved in protein targeting to mitochondrion term replaced by negative regulation of protein localization to mitochondrion

obsolete negative regulation of protein targeting to mitochondrion `http://purl.obolibrary.org/obo/GO_1903215`

Removed

obsolete negative regulation of protein targeting to mitochondrion term replaced by negative regulation of protein localization to mitochondrion

obsolete positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway `http://purl.obolibrary.org/obo/GO_1900740`

Removed

obsolete positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway consider positive regulation of protein localization to mitochondrion

obsolete positive regulation of protein targeting to mitochondrion `http://purl.obolibrary.org/obo/GO_1903955`

Removed

obsolete positive regulation of protein targeting to mitochondrion term replaced by positive regulation of protein localization to mitochondrion

obsolete protein mono-ADP-ribosylation `http://purl.obolibrary.org/obo/GO_0140289`

Removed

obsolete protein mono-ADP-ribosylation consider NAD+ poly-ADP-ribosyltransferase activity

Added

obsolete protein mono-ADP-ribosylation term tracker item “https://github.com/geneontology/go-ontology/issues/32538”^^anyURI
obsolete protein mono-ADP-ribosylation consider NAD+-protein mono-ADP-ribosyltransferase activity

obsolete regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway `http://purl.obolibrary.org/obo/GO_1900739`

Removed

obsolete regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway consider regulation of protein localization to mitochondrion

obsolete regulation of protein processing involved in protein targeting to mitochondrion `http://purl.obolibrary.org/obo/GO_1903216`

Removed

obsolete regulation of protein processing involved in protein targeting to mitochondrion term replaced by regulation of protein localization to mitochondrion

obsolete regulation of protein targeting to mitochondrion `http://purl.obolibrary.org/obo/GO_1903214`

Removed

obsolete regulation of protein targeting to mitochondrion term replaced by regulation of protein localization to mitochondrion

ocellus development `http://purl.obolibrary.org/obo/GO_0008056`

Removed

ocellus development definition “The process whose specific outcome is the progression of the ocellus over time, from its formation to the mature structure. The ocellus is a simple visual organ of insects.”
- database_cross_reference “http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540”

Added

ocellus development term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
ocellus development definition “The process whose specific outcome is the progression of the ocellus over time, from its formation to the mature structure. The ocellus is a simple visual organ of insects.”
- database_cross_reference “FBbt:00004505”

ocellus morphogenesis `http://purl.obolibrary.org/obo/GO_0048816`

Removed

ocellus morphogenesis definition “The process in which the anatomical structures of the ocellus are generated and organized. The ocellus is a simple visual organ of insects.”
- database_cross_reference “http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540”

Added

ocellus morphogenesis term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
ocellus morphogenesis definition “The process in which the anatomical structures of the ocellus are generated and organized. The ocellus is a simple visual organ of insects.”
- database_cross_reference “FBbt:00004505”

ocellus pigment granule organization `http://purl.obolibrary.org/obo/GO_0008058`

Removed

ocellus pigment granule organization definition “A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the ocellus.”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”
ocellus pigment granule organization label “ocellus pigment granule organization”
ocellus pigment granule organization SubClassOf pigment granule organization

Added

ocellus pigment granule organization term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
ocellus pigment granule organization definition “OBSOLETE. A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the ocellus.”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”
ocellus pigment granule organization deprecated true
ocellus pigment granule organization comment “The reason for obsoletion is that this term was made in error.”
ocellus pigment granule organization label “obsolete ocellus pigment granule organization”

organophosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0090407`

Added

organophosphate biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/32294”^^anyURI
organophosphate biosynthetic process in_subset gocheck_do_not_annotate

organophosphate catabolic process `http://purl.obolibrary.org/obo/GO_0046434`

Added

organophosphate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/32294”^^anyURI
organophosphate catabolic process in_subset gocheck_do_not_annotate

organophosphate metabolic process `http://purl.obolibrary.org/obo/GO_0019637`

Added

organophosphate metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/32294”^^anyURI
organophosphate metabolic process in_subset gocheck_do_not_annotate

outward rectifier potassium channel inhibitor activity `http://purl.obolibrary.org/obo/GO_0140628`

Removed

outward rectifier potassium channel inhibitor activity SubClassOf potassium channel inhibitor activity

Added

outward rectifier potassium channel inhibitor activity SubClassOf voltage-gated potassium channel inhibitor activity

palmitoyl hydrolase activity `http://purl.obolibrary.org/obo/GO_0098599`

Removed

palmitoyl hydrolase activity SubClassOf part of some macromolecule depalmitoylation

peptidyl-glutamate ADP-deribosylation `http://purl.obolibrary.org/obo/GO_0140291`

Removed

peptidyl-glutamate ADP-deribosylation definition “The removal of ADP-ribose from ADP-ribosylglutamate.”
- database_cross_reference “PMID:23481255”
peptidyl-glutamate ADP-deribosylation label “peptidyl-glutamate ADP-deribosylation”
peptidyl-glutamate ADP-deribosylation SubClassOf protein de-ADP-ribosylation

Added

peptidyl-glutamate ADP-deribosylation term tracker item “https://github.com/geneontology/go-ontology/issues/32538”^^anyURI
peptidyl-glutamate ADP-deribosylation consider ADP-ribosylglutamate-[protein] hydrolase activity
peptidyl-glutamate ADP-deribosylation definition “OBSOLETE. The removal of ADP-ribose from ADP-ribosylglutamate.”
- database_cross_reference “PMID:23481255”
peptidyl-glutamate ADP-deribosylation deprecated true
peptidyl-glutamate ADP-deribosylation comment “This term was obsoleted because it represents a molecular function.”
peptidyl-glutamate ADP-deribosylation label “obsolete peptidyl-glutamate ADP-deribosylation”

peptidyl-serine ADP-deribosylation `http://purl.obolibrary.org/obo/GO_0140290`

Removed

peptidyl-serine ADP-deribosylation definition “The removal of ADP-ribose from ADP-ribosylserine.”
- database_cross_reference “PMID:28650317”
- database_cross_reference “PMID:29234005”
peptidyl-serine ADP-deribosylation label “peptidyl-serine ADP-deribosylation”
peptidyl-serine ADP-deribosylation SubClassOf protein de-ADP-ribosylation

Added

peptidyl-serine ADP-deribosylation term tracker item “https://github.com/geneontology/go-ontology/issues/32538”^^anyURI
peptidyl-serine ADP-deribosylation consider ADP-ribosylserine-[protein] hydrolase activity
peptidyl-serine ADP-deribosylation definition “OBSOLETE. The removal of ADP-ribose from ADP-ribosylserine.”
- database_cross_reference “PMID:28650317”
- database_cross_reference “PMID:29234005”
peptidyl-serine ADP-deribosylation deprecated true
peptidyl-serine ADP-deribosylation comment “This term was obsoleted because it represents a molecular function.”
peptidyl-serine ADP-deribosylation label “obsolete peptidyl-serine ADP-deribosylation”

perforant pathway to dendrate granule cell synapse `http://purl.obolibrary.org/obo/GO_0140240`

Removed

perforant pathway to dendrate granule cell synapse label “perforant pathway to dendrate granule cell synapse”

Added

perforant pathway to dendrate granule cell synapse label “perforant pathway to dentate granule cell synapse”

periodic partitioning by pair rule gene `http://purl.obolibrary.org/obo/GO_0007366`

Removed

periodic partitioning by pair rule gene definition “Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities.”
- database_cross_reference “ISBN:0632030488”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

periodic partitioning by pair rule gene term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
periodic partitioning by pair rule gene definition “Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities.”
- database_cross_reference “ISBN:0632030488”
- database_cross_reference “ISBN:0879694238”

peroxiredoxin activity `http://purl.obolibrary.org/obo/GO_0051920`

Removed

peroxiredoxin activity database_cross_reference “RHEA:62624”
peroxiredoxin activity database_cross_reference “RHEA:62640”
peroxiredoxin activity narrowMatch 62624
peroxiredoxin activity narrowMatch 62640
peroxiredoxin activity definition “Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.”
- database_cross_reference “RHEA:10008”

Added

peroxiredoxin activity term tracker item “https://github.com/geneontology/go-ontology/issues/32405”^^anyURI
peroxiredoxin activity definition “Catalysis of the reaction: [protein]-dithiol + ROOH = [protein]-disulfide + H2O + ROH.”
- database_cross_reference “RHEA:10008”

peroxisomal protein quality control `http://purl.obolibrary.org/obo/GO_0170079`

Added

Class: peroxisomal protein quality control
peroxisomal protein quality control term tracker item “https://github.com/geneontology/go-ontology/issues/32442”^^anyURI
peroxisomal protein quality control created by “ew”
peroxisomal protein quality control creation date “2026-08-12T16:13:58Z”
peroxisomal protein quality control has_obo_namespace “biological_process”
peroxisomal protein quality control id “GO:0170079”
peroxisomal protein quality control definition “The chemical reactions and pathways resulting in the breakdown of dysfunctional peroxisomal proteins, independent of pexophagy.”
- database_cross_reference “PMID:25305535”
- database_cross_reference “PMID:37552037”
- database_cross_reference “PMID:19538506”
peroxisomal protein quality control label “peroxisomal protein quality control”
peroxisomal protein quality control SubClassOf protein quality control for misfolded or incompletely synthesized proteins
peroxisomal protein quality control SubClassOf protein catabolic process

phagocytosis, engulfment `http://purl.obolibrary.org/obo/GO_0006911`

Added

phagocytosis, engulfment term tracker item “https://github.com/geneontology/go-ontology/issues/32152”^^anyURI

phagolysosome assembly `http://purl.obolibrary.org/obo/GO_0001845`

Removed

phagolysosome assembly SubClassOf part of some phagocytosis

phagolysosome membrane `http://purl.obolibrary.org/obo/GO_0061474`

Removed

phagolysosome membrane definition “The lipid bilayer surrounding a phagolysosome.”
- database_cross_reference “PMID:22073313”
- database_cross_reference “GOC:dph”

Added

phagolysosome membrane has_exact_synonym “phagolysosome vesicle membrane”
phagolysosome membrane definition “The lipid bilayer surrounding a phagolysosome.”
- database_cross_reference “PMID:22073313”
- database_cross_reference “GOC:dph”
- database_cross_reference “PMID:29471269”

phagolysosome vesicle membrane `http://purl.obolibrary.org/obo/GO_0106175`

Removed

phagolysosome vesicle membrane definition “The lipid bylayer surrounding a phagolysosome.”
- database_cross_reference “PMID:29471269”
- database_cross_reference “GOC:pde”
phagolysosome vesicle membrane label “phagolysosome vesicle membrane”
phagolysosome vesicle membrane SubClassOf cytoplasmic vesicle membrane
phagolysosome vesicle membrane SubClassOf part of some phagolysosome

Added

phagolysosome vesicle membrane term tracker item “https://github.com/geneontology/go-ontology/issues/32571”^^anyURI
phagolysosome vesicle membrane term replaced by phagolysosome membrane
phagolysosome vesicle membrane definition “OBSOLETE. The lipid bilayer surrounding a phagolysosome.”
- database_cross_reference “PMID:29471269”
- database_cross_reference “GOC:pde”
phagolysosome vesicle membrane deprecated true
phagolysosome vesicle membrane comment “This term was obsoleted because it was created by error. It is identical to phagolysosome membrane ; GO:0061474.”
phagolysosome vesicle membrane label “obsolete phagolysosome vesicle membrane”

phagophore assembly site membrane `http://purl.obolibrary.org/obo/GO_0034045`

Removed

phagophore assembly site membrane definition “A cellular membrane associated with the phagophore assembly site.”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:16874040”
- database_cross_reference “PMID:17382324”
- database_cross_reference “GOC:rph”
phagophore assembly site membrane label “phagophore assembly site membrane”
phagophore assembly site membrane SubClassOf membrane
phagophore assembly site membrane SubClassOf part of some phagophore assembly site

Added

phagophore assembly site membrane term tracker item “https://github.com/geneontology/go-ontology/issues/29437”^^anyURI
phagophore assembly site membrane term replaced by phagophore membrane
phagophore assembly site membrane definition “OBSOLETE. A cellular membrane associated with the phagophore assembly site.”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:16874040”
- database_cross_reference “PMID:17382324”
- database_cross_reference “GOC:rph”
phagophore assembly site membrane deprecated true
phagophore assembly site membrane comment “This term was obsoleted because the phagophore assembly site (PAS) is not itself a membrane-bounded compartment, and the class had become a catch-all for membranes at, or associated with, the site of phagophore biogenesis. Annotations should be moved to phagophore membrane (GO:7770114), which captures the membrane of the nascent phagophore, or to another more appropriate term (e.g. GO:0000407 phagophore assembly site, GO:0061908 phagophore) depending on the evidence.”
phagophore assembly site membrane label “obsolete phagophore assembly site membrane”

phagophore membrane `http://purl.obolibrary.org/obo/GO_7770114`

Added

Class: phagophore membrane
phagophore membrane term tracker item “https://github.com/geneontology/go-ontology/issues/29437”^^anyURI
phagophore membrane created by “ai4c-agent”
phagophore membrane creation date “2026-08-19T23:59:26Z”
phagophore membrane has_obo_namespace “cellular_component”
phagophore membrane id “GO:7770114”
phagophore membrane definition “A membrane that is part of a phagophore.”
- database_cross_reference “PMID:33773106”
- database_cross_reference “PMID:23217709”
phagophore membrane comment “Covers the membrane of the nascent phagophore, including membrane contributed by Atg9/ATG9A-containing vesicles once they have been incorporated into the phagophore, and the membrane of the expanding cup-shaped structure. After the structure has closed, annotate to autophagosome membrane (GO:0000421) instead. Do not use for Atg9/ATG9A-containing vesicles themselves, either before or after their recruitment to the phagophore assembly site: a vesicle is a membrane-bounded structure, not a membrane.”
phagophore membrane label “phagophore membrane”
phagophore membrane SubClassOf membrane
phagophore membrane SubClassOf part of some phagophore

phagosome maturation `http://purl.obolibrary.org/obo/GO_0090382`

Removed

phagosome maturation SubClassOf has part some exocytosis

Added

phagosome maturation term tracker item “https://github.com/geneontology/go-ontology/issues/32152”^^anyURI
phagosome maturation SubClassOf part of some phagocytosis

phenylacetyl-CoA 1,2-epoxidase complex `http://purl.obolibrary.org/obo/GO_0062077`

Removed

phenylacetyl-CoA 1,2-epoxidase complex definition “A protein complex capable of catalysing the reaction: phenylacetyl-CoA + H+ + NADPH + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP+.”
- database_cross_reference “PMID:21247899”
- database_cross_reference “GOC:bhm”

Added

phenylacetyl-CoA 1,2-epoxidase complex definition “A protein complex capable of catalyzing the reaction: phenylacetyl-CoA + H+ + NADPH + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP+.”
- database_cross_reference “PMID:21247899”
- database_cross_reference “GOC:bhm”

phenylalanyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0006432`

Removed

phenylalanyl-tRNA aminoacylation definition “The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2’-OH group of a phenylalanine-accepting tRNA. The 2’-O-aminoacyl-tRNA will ultimately migrate to the 3’ position via transesterification.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
phenylalanyl-tRNA aminoacylation label “phenylalanyl-tRNA aminoacylation”
phenylalanyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for protein translation

Added

phenylalanyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
phenylalanyl-tRNA aminoacylation term replaced by tRNA aminoacylation for protein translation
phenylalanyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2’-OH group of a phenylalanine-accepting tRNA. The 2’-O-aminoacyl-tRNA will ultimately migrate to the 3’ position via transesterification.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
phenylalanyl-tRNA aminoacylation deprecated true
phenylalanyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004826 phenylalanine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0006418 tRNA aminoacylation for protein translation.”
phenylalanyl-tRNA aminoacylation label “obsolete phenylalanyl-tRNA aminoacylation”

phosphocreatine metabolic process `http://purl.obolibrary.org/obo/GO_0006603`

Added

phosphocreatine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/32279”^^anyURI

phosphopantetheine-dependent carrier activity `http://purl.obolibrary.org/obo/GO_0140414`

Removed

phosphopantetheine-dependent carrier activity definition “Binding a substrate via a thioester at the terminal thiol of a covalentely linked phosphopantetheine prosthetic group and mediating protein-protein interactions with cognate enzymes for processing or offloading of the thiol-bound substrate.”
- database_cross_reference “PMID:17502372”

Added

phosphopantetheine-dependent carrier activity definition “Binding a substrate via a thioester at the terminal thiol of a covalently linked phosphopantetheine prosthetic group and mediating protein-protein interactions with cognate enzymes for processing or offloading of the thiol-bound substrate.”
- database_cross_reference “PMID:17502372”

phytanate-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0050197`

Removed

phytanate-CoA ligase activity definition “Catalysis of the reaction: ATP + CoA + phytanate = AMP + diphosphate + H+ + phytanoyl-CoA.”
- database_cross_reference “EC:6.2.1.24”
- database_cross_reference “RHEA:21380”
phytanate-CoA ligase activity SubClassOf CoA-ligase activity

Added

phytanate-CoA ligase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32501”^^anyURI
phytanate-CoA ligase activity definition “Catalysis of the reaction: ATP + CoA + phytanate = AMP + diphosphate + H+ + phytanoyl-CoA.”
- database_cross_reference “RHEA:21380”
phytanate-CoA ligase activity SubClassOf fatty acid-CoA ligase activity

positive regulation of ERAD pathway `http://purl.obolibrary.org/obo/GO_1904294`

Removed

positive regulation of ERAD pathway SubClassOf positive regulation of response to endoplasmic reticulum stress

positive regulation of cardiac endothelial to mesenchymal transition `http://purl.obolibrary.org/obo/GO_0062000`

Removed

positive regulation of cardiac endothelial to mesenchymal transition definition “Any process that activates or increases the frequency, rate or extent of cardiac endothelial to mesenchymal trnasition.”
- database_cross_reference “PMID:26857067”
- database_cross_reference “GOC:BHF_miRNA”
- database_cross_reference “GOC:BHF”
- database_cross_reference “GOC:rph”

Added

positive regulation of cardiac endothelial to mesenchymal transition definition “Any process that activates or increases the frequency, rate or extent of cardiac endothelial to mesenchymal transition.”
- database_cross_reference “PMID:26857067”
- database_cross_reference “GOC:BHF_miRNA”
- database_cross_reference “GOC:BHF”
- database_cross_reference “GOC:rph”

positive regulation of cristae formation `http://purl.obolibrary.org/obo/GO_1903852`

Removed

positive regulation of cristae formation SubClassOf positive regulation of organelle organization

Added

positive regulation of cristae formation SubClassOf positive regulation of cellular component organization

positive regulation of establishment of bipolar cell polarity regulating cell shape `http://purl.obolibrary.org/obo/GO_0061161`

Removed

positive regulation of establishment of bipolar cell polarity regulating cell shape definition “Any process that increases the rate, frequency or extent of the establishment of bipolar cell polarity that regulates the shape of a cell.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:vw”
positive regulation of establishment of bipolar cell polarity regulating cell shape label “positive regulation of establishment of bipolar cell polarity regulating cell shape”
positive regulation of establishment of bipolar cell polarity regulating cell shape SubClassOf regulation of establishment of bipolar cell polarity regulating cell shape
positive regulation of establishment of bipolar cell polarity regulating cell shape SubClassOf positive regulation of establishment of bipolar cell polarity
positive regulation of establishment of bipolar cell polarity regulating cell shape SubClassOf positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape

Added

positive regulation of establishment of bipolar cell polarity regulating cell shape term tracker item “https://github.com/geneontology/go-ontology/issues/21217”^^anyURI
positive regulation of establishment of bipolar cell polarity regulating cell shape term replaced by establishment or maintenance of bipolar cell polarity
positive regulation of establishment of bipolar cell polarity regulating cell shape definition “OBSOLETE. Any process that increases the rate, frequency or extent of the establishment of bipolar cell polarity that regulates the shape of a cell.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:vw”
positive regulation of establishment of bipolar cell polarity regulating cell shape deprecated true
positive regulation of establishment of bipolar cell polarity regulating cell shape comment “The reason for obsoletion is that this term was made in error.”
positive regulation of establishment of bipolar cell polarity regulating cell shape label “obsolete positive regulation of establishment of bipolar cell polarity regulating cell shape”

positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape `http://purl.obolibrary.org/obo/GO_2000247`

Removed

positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape definition “Any process that activates or increases the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape.”
- database_cross_reference “GOC:obol”
positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape label “positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape”
positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape EquivalentTo biological regulation and (positively regulates some establishment or maintenance of bipolar cell polarity regulating cell shape)
positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape SubClassOf regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape SubClassOf positive regulation of establishment or maintenance of cell polarity regulating cell shape
positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape SubClassOf positively regulates some establishment or maintenance of bipolar cell polarity regulating cell shape

Added

positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape term tracker item “https://github.com/geneontology/go-ontology/issues/21217”^^anyURI
positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape term replaced by establishment or maintenance of bipolar cell polarity
positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape.”
- database_cross_reference “GOC:obol”
positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape deprecated true
positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape comment “The reason for obsoletion is that these terms were added in error.”
positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape label “obsolete positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape”

positive regulation of glycolytic process `http://purl.obolibrary.org/obo/GO_0045821`

Removed

positive regulation of glycolytic process label “positive regulation of glycolytic process”

Added

positive regulation of glycolytic process has_exact_synonym “positive regulation of glycolytic process”
positive regulation of glycolytic process label “positive regulation of glycolysis”

positive regulation of glycolytic process through fructose-6-phosphate `http://purl.obolibrary.org/obo/GO_1904540`

Removed

positive regulation of glycolytic process through fructose-6-phosphate definition “Any process that activates or increases the frequency, rate or extent of glycolytic process through fructose-6-phosphate.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “ISBN:0879010479”
- database_cross_reference “ISBN:0201090910”
- database_cross_reference “GO_REF:0000058”
positive regulation of glycolytic process through fructose-6-phosphate label “positive regulation of glycolytic process through fructose-6-phosphate”
positive regulation of glycolytic process through fructose-6-phosphate EquivalentTo biological regulation and (positively regulates some glycolytic process through fructose-6-phosphate)
positive regulation of glycolytic process through fructose-6-phosphate SubClassOf positive regulation of glycolytic process
positive regulation of glycolytic process through fructose-6-phosphate SubClassOf positively regulates some glycolytic process through fructose-6-phosphate

Added

positive regulation of glycolytic process through fructose-6-phosphate term tracker item “https://github.com/geneontology/go-ontology/issues/32471”^^anyURI
positive regulation of glycolytic process through fructose-6-phosphate term replaced by positive regulation of glycolytic process
positive regulation of glycolytic process through fructose-6-phosphate definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of glycolytic process through fructose-6-phosphate.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “ISBN:0879010479”
- database_cross_reference “ISBN:0201090910”
- database_cross_reference “GO_REF:0000058”
positive regulation of glycolytic process through fructose-6-phosphate deprecated true
positive regulation of glycolytic process through fructose-6-phosphate comment “The reason for obsoletion is that this term represents a GO-CAM model.”
positive regulation of glycolytic process through fructose-6-phosphate label “obsolete positive regulation of glycolytic process through fructose-6-phosphate”

positive regulation of maintenance of bipolar cell polarity regulating cell shape `http://purl.obolibrary.org/obo/GO_0061361`

Removed

positive regulation of maintenance of bipolar cell polarity regulating cell shape definition “Any process that increases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape.”
- database_cross_reference “GOC:dph”
positive regulation of maintenance of bipolar cell polarity regulating cell shape label “positive regulation of maintenance of bipolar cell polarity regulating cell shape”
positive regulation of maintenance of bipolar cell polarity regulating cell shape SubClassOf regulation of maintenance of bipolar cell polarity regulating cell shape
positive regulation of maintenance of bipolar cell polarity regulating cell shape SubClassOf positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
positive regulation of maintenance of bipolar cell polarity regulating cell shape SubClassOf positively regulates some maintenance of bipolar cell polarity regulating cell shape

Added

positive regulation of maintenance of bipolar cell polarity regulating cell shape term tracker item “https://github.com/geneontology/go-ontology/issues/21217”^^anyURI
positive regulation of maintenance of bipolar cell polarity regulating cell shape term replaced by establishment or maintenance of bipolar cell polarity
positive regulation of maintenance of bipolar cell polarity regulating cell shape definition “OBSOLETE. Any process that increases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape.”
- database_cross_reference “GOC:dph”
positive regulation of maintenance of bipolar cell polarity regulating cell shape deprecated true
positive regulation of maintenance of bipolar cell polarity regulating cell shape comment “The reason for obsoletion is that this term was made in error.”
positive regulation of maintenance of bipolar cell polarity regulating cell shape label “obsolete positive regulation of maintenance of bipolar cell polarity regulating cell shape”

positive regulation of protein localization to mitochondrion `http://purl.obolibrary.org/obo/GO_1903749`

Removed

positive regulation of protein localization to mitochondrion term tracker item “https://github.com/geneontology/go-ontology/issues/30349”^^anyURI
positive regulation of protein localization to mitochondrion definition “Any process that activates or increases the frequency, rate or extent of protein localization to mitochondrion.”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:16857185”
- database_cross_reference “GO_REF:0000058”
positive regulation of protein localization to mitochondrion label “positive regulation of protein localization to mitochondrion”
positive regulation of protein localization to mitochondrion EquivalentTo biological regulation and (positively regulates some protein localization to mitochondrion)
positive regulation of protein localization to mitochondrion SubClassOf regulation of protein localization to mitochondrion
positive regulation of protein localization to mitochondrion SubClassOf positive regulation of protein localization
positive regulation of protein localization to mitochondrion SubClassOf positively regulates some protein localization to mitochondrion

Added

positive regulation of protein localization to mitochondrion term tracker item “https://github.com/geneontology/go-ontology/issues/32107”^^anyURI
positive regulation of protein localization to mitochondrion definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of protein localization to mitochondrion.”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:16857185”
- database_cross_reference “GO_REF:0000058”
positive regulation of protein localization to mitochondrion deprecated true
positive regulation of protein localization to mitochondrion comment “The reason for obsoletion is that this term represents a phenotype and was added in error. Consider annotating to positive regulation of the specific process being regulated (e.g. positive regulation of mitophagy) or to a specific mitochondrial protein import pathway; if the underlying evidence is a readout or a phenotype, or the mechanism is unclear, consider removal rather than re-annotation.”
positive regulation of protein localization to mitochondrion label “obsolete positive regulation of protein localization to mitochondrion”

positive regulation of retrograde protein transport, ER to cytosol `http://purl.obolibrary.org/obo/GO_1904154`

Removed

positive regulation of retrograde protein transport, ER to cytosol definition “Any process that activates or increases the frequency, rate or extent of retrograde protein transport, ER to cytosol.”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:PARL”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:18555783”
- database_cross_reference “GO_REF:0000058”
positive regulation of retrograde protein transport, ER to cytosol label “positive regulation of retrograde protein transport, ER to cytosol”
positive regulation of retrograde protein transport, ER to cytosol EquivalentTo biological regulation and (positively regulates some retrograde protein transport, ER to cytosol)
positive regulation of retrograde protein transport, ER to cytosol SubClassOf positive regulation of protein transport
positive regulation of retrograde protein transport, ER to cytosol SubClassOf regulation of retrograde protein transport, ER to cytosol
positive regulation of retrograde protein transport, ER to cytosol SubClassOf positively regulates some retrograde protein transport, ER to cytosol

Added

positive regulation of retrograde protein transport, ER to cytosol term tracker item “https://github.com/geneontology/go-ontology/issues/32525”^^anyURI
positive regulation of retrograde protein transport, ER to cytosol term replaced by positive regulation of ERAD pathway
positive regulation of retrograde protein transport, ER to cytosol definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of retrograde protein transport, ER to cytosol.”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:PARL”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:18555783”
- database_cross_reference “GO_REF:0000058”
positive regulation of retrograde protein transport, ER to cytosol deprecated true
positive regulation of retrograde protein transport, ER to cytosol comment “The reason for obsoletion is that the term is not clearly defined and usage has been inconsistent, the data from the paper for which the term was requested can be accurately described using reguation of ERAD pathway terms, and this term was added in error.”
positive regulation of retrograde protein transport, ER to cytosol label “obsolete positive regulation of retrograde protein transport, ER to cytosol”

positive regulation of sulfate assimilation `http://purl.obolibrary.org/obo/GO_1900059`

Removed

positive regulation of sulfate assimilation SubClassOf positive regulation of metabolic process

Added

positive regulation of sulfate assimilation SubClassOf positive regulation of small molecule metabolic process

positive regulation of transcription from RNA polymerase II promoter by galactose `http://purl.obolibrary.org/obo/GO_0000435`

Removed

positive regulation of transcription from RNA polymerase II promoter by galactose definition “Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter.”
- database_cross_reference “GOC:krc”
positive regulation of transcription from RNA polymerase II promoter by galactose label “positive regulation of transcription from RNA polymerase II promoter by galactose”
positive regulation of transcription from RNA polymerase II promoter by galactose SubClassOf positive regulation of transcription by galactose
positive regulation of transcription from RNA polymerase II promoter by galactose SubClassOf regulation of transcription from RNA polymerase II promoter by galactose
positive regulation of transcription from RNA polymerase II promoter by galactose SubClassOf carbon catabolite activation of transcription from RNA polymerase II promoter

Added

positive regulation of transcription from RNA polymerase II promoter by galactose term tracker item “https://github.com/geneontology/go-ontology/issues/21442”^^anyURI
positive regulation of transcription from RNA polymerase II promoter by galactose consider positive regulation of transcription by RNA polymerase II
positive regulation of transcription from RNA polymerase II promoter by galactose definition “OBSOLETE. Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter.”
- database_cross_reference “GOC:krc”
positive regulation of transcription from RNA polymerase II promoter by galactose deprecated true
positive regulation of transcription from RNA polymerase II promoter by galactose comment “The reason for obsoletion is that these terms represent GO-CAM models.”
positive regulation of transcription from RNA polymerase II promoter by galactose label “obsolete positive regulation of transcription from RNA polymerase II promoter by galactose”

positive regulation of transcription from RNA polymerase II promoter by glucose `http://purl.obolibrary.org/obo/GO_0000432`

Removed

positive regulation of transcription from RNA polymerase II promoter by glucose definition “Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter.”
- database_cross_reference “GOC:krc”
positive regulation of transcription from RNA polymerase II promoter by glucose label “positive regulation of transcription from RNA polymerase II promoter by glucose”
positive regulation of transcription from RNA polymerase II promoter by glucose SubClassOf regulation of transcription from RNA polymerase II promoter by glucose
positive regulation of transcription from RNA polymerase II promoter by glucose SubClassOf carbon catabolite activation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter by glucose SubClassOf positive regulation of transcription by glucose

Added

positive regulation of transcription from RNA polymerase II promoter by glucose term tracker item “https://github.com/geneontology/go-ontology/issues/21442”^^anyURI
positive regulation of transcription from RNA polymerase II promoter by glucose consider positive regulation of transcription by RNA polymerase II
positive regulation of transcription from RNA polymerase II promoter by glucose definition “OBSOLETE. Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter.”
- database_cross_reference “GOC:krc”
positive regulation of transcription from RNA polymerase II promoter by glucose deprecated true
positive regulation of transcription from RNA polymerase II promoter by glucose comment “The reason for obsoletion is that these terms represent GO-CAM models.”
positive regulation of transcription from RNA polymerase II promoter by glucose label “obsolete positive regulation of transcription from RNA polymerase II promoter by glucose”

positive regulation of transcription from RNA polymerase II promoter by oleic acid `http://purl.obolibrary.org/obo/GO_0061429`

Removed

positive regulation of transcription from RNA polymerase II promoter by oleic acid definition “Any process involving oleic acid that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.”
- database_cross_reference “GOC:dph”
- database_cross_reference “PMID:20395639”
positive regulation of transcription from RNA polymerase II promoter by oleic acid label “positive regulation of transcription from RNA polymerase II promoter by oleic acid”
positive regulation of transcription from RNA polymerase II promoter by oleic acid SubClassOf carbon catabolite activation of transcription from RNA polymerase II promoter

Added

positive regulation of transcription from RNA polymerase II promoter by oleic acid term tracker item “https://github.com/geneontology/go-ontology/issues/21442”^^anyURI
positive regulation of transcription from RNA polymerase II promoter by oleic acid consider positive regulation of transcription by RNA polymerase II
positive regulation of transcription from RNA polymerase II promoter by oleic acid definition “OBSOLETE. Any process involving oleic acid that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.”
- database_cross_reference “GOC:dph”
- database_cross_reference “PMID:20395639”
positive regulation of transcription from RNA polymerase II promoter by oleic acid deprecated true
positive regulation of transcription from RNA polymerase II promoter by oleic acid comment “The reason for obsoletion is that these terms represent GO-CAM models.”
positive regulation of transcription from RNA polymerase II promoter by oleic acid label “obsolete positive regulation of transcription from RNA polymerase II promoter by oleic acid”

posterior abdomen determination `http://purl.obolibrary.org/obo/GO_0007359`

Removed

posterior abdomen determination definition “The regionalization process in which the posterior (abdominal) regions of the embryo are specified by the gap genes.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:isa_complete”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

posterior abdomen determination term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
posterior abdomen determination definition “The regionalization process in which the posterior (abdominal) regions of the embryo are specified by the gap genes.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:isa_complete”
- database_cross_reference “ISBN:0879694238”

posterior compartment specification `http://purl.obolibrary.org/obo/GO_0007388`

Removed

posterior compartment specification definition “The process involved in the specification of cell identity in the posterior compartments of the segmented embryo.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

posterior compartment specification term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
posterior compartment specification definition “The process involved in the specification of cell identity in the posterior compartments of the segmented embryo.”
- database_cross_reference “ISBN:0879694238”

postsynaptic early endosome `http://purl.obolibrary.org/obo/GO_0098842`

Removed

postsynaptic early endosome definition “An early endosome of the postsynapse. It acts as the major sorting station on the endocytic pathway, targeting neurotransmitter receptors for degregation or recycling.”
- database_cross_reference “PMID:20820847”
- database_cross_reference “PMID:19603039”
- database_cross_reference “PMID:24727350”

Added

postsynaptic early endosome definition “An early endosome of the postsynapse. It acts as the major sorting station on the endocytic pathway, targeting neurotransmitter receptors for degradation or recycling.”
- database_cross_reference “PMID:20820847”
- database_cross_reference “PMID:19603039”
- database_cross_reference “PMID:24727350”

pre-B cell receptor expression `http://purl.obolibrary.org/obo/GO_0002330`

Removed

pre-B cell receptor expression definition “The process leading up to expression of the pre-B cell receptor on the surface of pre-B cells, starting with the recombination of an immunuglobulin heavy chain locus, including expression of the surrogate light chain, the association of the surrogate light chain with the heavy chain, and expression of the complete pre-B cell receptor on the cell surface. pre-B cell receptor expression is a key checkpoint in the transition of pro-B cell to pre-B cell.”
- database_cross_reference “PMID:9834086”
- database_cross_reference “GOC:add”
- database_cross_reference “PMID:22949502”
- database_cross_reference “PMID:15263090”
- database_cross_reference “GOC:jal”

Added

pre-B cell receptor expression definition “The process leading up to expression of the pre-B cell receptor on the surface of pre-B cells, starting with the recombination of an immunoglobulin heavy chain locus, including expression of the surrogate light chain, the association of the surrogate light chain with the heavy chain, and expression of the complete pre-B cell receptor on the cell surface. pre-B cell receptor expression is a key checkpoint in the transition of pro-B cell to pre-B cell.”
- database_cross_reference “PMID:9834086”
- database_cross_reference “GOC:add”
- database_cross_reference “PMID:22949502”
- database_cross_reference “PMID:15263090”
- database_cross_reference “GOC:jal”

prolyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0006433`

Removed

prolyl-tRNA aminoacylation definition “The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3’-OH group of a methionine-accetping tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “ISBN:0716730510”
prolyl-tRNA aminoacylation label “prolyl-tRNA aminoacylation”
prolyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for protein translation

Added

prolyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
prolyl-tRNA aminoacylation term replaced by tRNA aminoacylation for protein translation
prolyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3’-OH group of a methionine-accetping tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “ISBN:0716730510”
prolyl-tRNA aminoacylation deprecated true
prolyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004827 proline-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0006418 tRNA aminoacylation for protein translation.”
prolyl-tRNA aminoacylation label “obsolete prolyl-tRNA aminoacylation”

proteasomal degradation of multi-protein complex orphan subunits `http://purl.obolibrary.org/obo/GO_7770117`

Added

Class: proteasomal degradation of multi-protein complex orphan subunits
proteasomal degradation of multi-protein complex orphan subunits term tracker item “https://github.com/geneontology/go-ontology/issues/32274”^^anyURI
proteasomal degradation of multi-protein complex orphan subunits created by “ai4c-agent”
proteasomal degradation of multi-protein complex orphan subunits creation date “2026-08-27T23:33:52Z”
proteasomal degradation of multi-protein complex orphan subunits has_broad_synonym “degradation of orphan subunits of multi-protein complexes”
proteasomal degradation of multi-protein complex orphan subunits has_broad_synonym “orphan subunit degradation”
proteasomal degradation of multi-protein complex orphan subunits has_obo_namespace “biological_process”
proteasomal degradation of multi-protein complex orphan subunits id “GO:7770117”
proteasomal degradation of multi-protein complex orphan subunits definition “A protein quality control pathway that results in the ubiquitin-dependent, proteasome-mediated breakdown of orphan subunits of a multi-protein complex (including complexes that also contain non-protein components, such as the ribosome), i.e. subunits that have failed to assemble into their cognate complex, for example as a result of imbalanced subunit synthesis. This process eliminates unassembled subunits and thereby maintains protein complex stoichiometry.”
- database_cross_reference “PMID:35316660”
- database_cross_reference “PMID:28774922”
- database_cross_reference “PMID:37480851”
proteasomal degradation of multi-protein complex orphan subunits label “proteasomal degradation of multi-protein complex orphan subunits”
proteasomal degradation of multi-protein complex orphan subunits SubClassOf protein quality control for misfolded or incompletely synthesized proteins
proteasomal degradation of multi-protein complex orphan subunits SubClassOf proteasome-mediated ubiquitin-dependent protein catabolic process

proteasome substrate carrier activity `http://purl.obolibrary.org/obo/GO_0170082`

Added

Class: proteasome substrate carrier activity
proteasome substrate carrier activity term tracker item “https://github.com/geneontology/go-ontology/issues/32506”^^anyURI
proteasome substrate carrier activity created by “ew”
proteasome substrate carrier activity creation date “2026-08-25T15:54:46Z”
proteasome substrate carrier activity has_broad_synonym “ubiquitin receptor”
proteasome substrate carrier activity has_exact_synonym “proteasome substrate carrier”
proteasome substrate carrier activity has_obo_namespace “molecular_function”
proteasome substrate carrier activity id “GO:0170082”
proteasome substrate carrier activity definition “A protein carrier activity that recognizes and binds a polyubiquitinated substrate, usually via a UBA or similar ubiquitin-binding domain, and delivers it to the 26S proteasome by docking onto the 19S regulatory particle and releasing the substrate.”
- database_cross_reference “PMID:33211406”
proteasome substrate carrier activity label “proteasome substrate carrier activity”
proteasome substrate carrier activity SubClassOf protein carrier activity
proteasome substrate carrier activity SubClassOf has part some polyubiquitin modification-dependent protein binding
proteasome substrate carrier activity SubClassOf has part some proteasome binding

protein auto-ADP-ribosylation `http://purl.obolibrary.org/obo/GO_0070213`

Removed

protein auto-ADP-ribosylation definition “The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein.”
- database_cross_reference “GOC:rl”
- database_cross_reference “GOC:BHF”
protein auto-ADP-ribosylation label “protein auto-ADP-ribosylation”
protein auto-ADP-ribosylation SubClassOf post-translational protein modification

Added

protein auto-ADP-ribosylation term tracker item “https://github.com/geneontology/go-ontology/issues/32538”^^anyURI
protein auto-ADP-ribosylation consider NAD+ poly-ADP-ribosyltransferase activity
protein auto-ADP-ribosylation consider NAD+-protein mono-ADP-ribosyltransferase activity
protein auto-ADP-ribosylation definition “OBSOLETE. The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein.”
- database_cross_reference “GOC:rl”
- database_cross_reference “GOC:BHF”
protein auto-ADP-ribosylation deprecated true
protein auto-ADP-ribosylation comment “This term was obsoleted because it represents a molecular function.”
protein auto-ADP-ribosylation label “obsolete protein auto-ADP-ribosylation”

protein depalmitoylation `http://purl.obolibrary.org/obo/GO_0002084`

Removed

protein depalmitoylation in_subset gocheck_obsoletion_candidate
protein depalmitoylation definition “The removal of palymitoyl groups from a lipoprotein.”
- database_cross_reference “GOC:hjd”
protein depalmitoylation label “protein depalmitoylation”
protein depalmitoylation SubClassOf protein deacylation
protein depalmitoylation SubClassOf lipoprotein catabolic process
protein depalmitoylation SubClassOf macromolecule depalmitoylation

Added

protein depalmitoylation term tracker item “https://github.com/geneontology/go-ontology/issues/32290”^^anyURI
protein depalmitoylation consider palmitoyl-(protein) hydrolase activity
protein depalmitoylation definition “OBSOLETE. The removal of palymitoyl groups from a lipoprotein.”
- database_cross_reference “GOC:hjd”
protein depalmitoylation deprecated true
protein depalmitoylation comment “The reason for obsoletion is that this term represents a molecular function, not a biological process. Consider instead annotating to the molecular function ‘palmitoyl-(protein) hydrolase activity’ (GO:0008474).”
protein depalmitoylation label “obsolete protein depalmitoylation”

protein insertion into mitochondrial membrane `http://purl.obolibrary.org/obo/GO_0051204`

Removed

protein insertion into mitochondrial membrane SubClassOf establishment of localization in cell

protein lipoylation `http://purl.obolibrary.org/obo/GO_0009249`

Removed

protein lipoylation definition “The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine.”
- database_cross_reference “RESID:AA0118”

Added

protein lipoylation term tracker item “https://github.com/geneontology/go-ontology/issues/32418”^^anyURI
protein lipoylation has_narrow_synonym “lipoate biosynthesis”
protein lipoylation has_narrow_synonym “lipoate biosynthetic process”
protein lipoylation has_narrow_synonym “lipoic acid biosynthetic process”
protein lipoylation definition “The chemical reactions and pathways resulting in the attachment of a lipoyl group to a lipoyl carrier protein, either by de novo assembly on the carrier protein via transfer of an octanoyl group followed by sulfur insertion, or by ligation of exogenous lipoate.”
- database_cross_reference “RESID:AA0118”
- database_cross_reference “PMID:29987032”
protein lipoylation SubClassOf lipoate metabolic process

protein localization to cytoplasmic stress granule `http://purl.obolibrary.org/obo/GO_1903608`

Removed

protein localization to cytoplasmic stress granule definition “A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule.”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:24755092”
- database_cross_reference “GO_REF:0000087”
protein localization to cytoplasmic stress granule label “protein localization to cytoplasmic stress granule”
protein localization to cytoplasmic stress granule SubClassOf protein localization to organelle

Added

protein localization to cytoplasmic stress granule term tracker item “https://github.com/geneontology/go-ontology/issues/32318”^^anyURI
protein localization to cytoplasmic stress granule definition “OBSOLETE. A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule.”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:24755092”
- database_cross_reference “GO_REF:0000087”
protein localization to cytoplasmic stress granule deprecated true
protein localization to cytoplasmic stress granule comment “The reason for obsoletion is that the term is not clearly defined and usage has been inconsistent. In practice it was applied to proteins observed in stress granules, that is, to a co-localization readout rather than to a process that localizes a protein there. Annotations to this term have been reviewed and removed; see https://github.com/geneontology/go-annotation/issues/6484.”
protein localization to cytoplasmic stress granule label “obsolete protein localization to cytoplasmic stress granule”

protein poly-ADP-ribosylation `http://purl.obolibrary.org/obo/GO_0070212`

Removed

protein poly-ADP-ribosylation definition “The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain.”
- database_cross_reference “PMID:25043379”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:rl”
- database_cross_reference “GOC:BHF”
protein poly-ADP-ribosylation label “protein poly-ADP-ribosylation”
protein poly-ADP-ribosylation SubClassOf post-translational protein modification

Added

protein poly-ADP-ribosylation term tracker item “https://github.com/geneontology/go-ontology/issues/32538”^^anyURI
protein poly-ADP-ribosylation consider NAD+ poly-ADP-ribosyltransferase activity
protein poly-ADP-ribosylation definition “OBSOLETE. The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain.”
- database_cross_reference “PMID:25043379”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:rl”
- database_cross_reference “GOC:BHF”
protein poly-ADP-ribosylation deprecated true
protein poly-ADP-ribosylation comment “This term was obsoleted because it represents a molecular function.”
protein poly-ADP-ribosylation label “obsolete protein poly-ADP-ribosylation”

protein processing in phagocytic vesicle `http://purl.obolibrary.org/obo/GO_1900756`

Added

protein processing in phagocytic vesicle term tracker item “https://github.com/geneontology/go-ontology/issues/32152”^^anyURI
protein processing in phagocytic vesicle SubClassOf part of some phagocytosis

protein quality control for misfolded or incompletely synthesized proteins `http://purl.obolibrary.org/obo/GO_0006515`

Removed

protein quality control for misfolded or incompletely synthesized proteins has_broad_synonym “protein quality control by the ubiquitin-proteasome system”
protein quality control for misfolded or incompletely synthesized proteins has_exact_synonym “degradation of misfolded or incompletely synthesized proteins”
protein quality control for misfolded or incompletely synthesized proteins has_exact_synonym “misfolded or incompletely synthesized protein breakdown”
protein quality control for misfolded or incompletely synthesized proteins has_exact_synonym “misfolded or incompletely synthesized protein catabolic process”
protein quality control for misfolded or incompletely synthesized proteins has_exact_synonym “misfolded or incompletely synthesized protein catabolism”
protein quality control for misfolded or incompletely synthesized proteins has_exact_synonym “misfolded or incompletely synthesized protein degradation”
protein quality control for misfolded or incompletely synthesized proteins has_exact_synonym “protein quality control (PQC)”
protein quality control for misfolded or incompletely synthesized proteins definition “The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins.”
- database_cross_reference “GOC:jl”
protein quality control for misfolded or incompletely synthesized proteins label “protein quality control for misfolded or incompletely synthesized proteins”
protein quality control for misfolded or incompletely synthesized proteins SubClassOf protein catabolic process

Added

protein quality control for misfolded or incompletely synthesized proteins term tracker item “https://github.com/geneontology/go-ontology/issues/32274”^^anyURI
protein quality control for misfolded or incompletely synthesized proteins term tracker item “https://github.com/geneontology/go-ontology/issues/32442”^^anyURI
protein quality control for misfolded or incompletely synthesized proteins term tracker item “https://github.com/geneontology/go-ontology/issues/32546”^^anyURI
protein quality control for misfolded or incompletely synthesized proteins has_exact_synonym “PQC”
protein quality control for misfolded or incompletely synthesized proteins has_narrow_synonym “degradation of misfolded or incompletely synthesized proteins”
protein quality control for misfolded or incompletely synthesized proteins has_narrow_synonym “misfolded or incompletely synthesized protein breakdown”
protein quality control for misfolded or incompletely synthesized proteins has_narrow_synonym “misfolded or incompletely synthesized protein catabolic process”
protein quality control for misfolded or incompletely synthesized proteins has_narrow_synonym “misfolded or incompletely synthesized protein catabolism”
protein quality control for misfolded or incompletely synthesized proteins has_narrow_synonym “misfolded or incompletely synthesized protein degradation”
protein quality control for misfolded or incompletely synthesized proteins has_narrow_synonym “protein quality control by the ubiquitin-proteasome system”
protein quality control for misfolded or incompletely synthesized proteins has_narrow_synonym “protein quality control for misfolded or incompletely synthesized proteins”
protein quality control for misfolded or incompletely synthesized proteins definition “A cellular process that monitors the folding, integrity, and assembly state of proteins and acts on those recognized as aberrant, including misfolded, damaged, dysfunctional, or incompletely synthesized proteins, and orphan subunits that fail to assemble into their cognate protein complex, by refolding, stabilizing, sequestering, retaining, or degrading them.”
- database_cross_reference “PMID:35316660”
- database_cross_reference “PMID:30075143”
- database_cross_reference “PMID:21746797”
- database_cross_reference “PMID:32075773”
protein quality control for misfolded or incompletely synthesized proteins label “protein quality control”
protein quality control for misfolded or incompletely synthesized proteins SubClassOf cellular process

protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity `http://purl.obolibrary.org/obo/GO_0008982`

Removed

protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity SubClassOf active transmembrane transporter activity

Added

protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/27496”^^anyURI
protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity SubClassOf group translocator activity

protein-exporting ATPase activity `http://purl.obolibrary.org/obo/GO_0008564`

Removed

protein-exporting ATPase activity definition “Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) = ADP + phosphate + protein+(out); drives the concomitant secretion of proteins.”
- database_cross_reference “EC:7.4.2.8”
- database_cross_reference “PMID:30346996”

Added

protein-exporting ATPase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32395”^^anyURI
protein-exporting ATPase activity definition “Enables the transfer of a protein from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) = ADP + phosphate + protein+(out); drives the concomitant secretion of proteins.”
- database_cross_reference “EC:7.4.2.8”
- database_cross_reference “PMID:30346996”

protein-phosphatidylethanolamide deconjugating activity `http://purl.obolibrary.org/obo/GO_0019786`

Removed

protein-phosphatidylethanolamide deconjugating activity has_exact_synonym “Atg8-specific protease activity”
protein-phosphatidylethanolamide deconjugating activity has_related_synonym “APG8-PE hydrolase”
protein-phosphatidylethanolamide deconjugating activity definition “Catalysis of the reaction: [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine. An example of this reaction is the removal of ATG8 from membranes to which it is covalently linked to a phosphatidylethanolamid via its terminal glycine residue.”
- database_cross_reference “PMID:28330855”
- database_cross_reference “PMID:22240591”
- database_cross_reference “PMID:2882172”
- database_cross_reference “PMID:22652539”
- database_cross_reference “PMID:28901328”
protein-phosphatidylethanolamide deconjugating activity label “protein-phosphatidylethanolamide deconjugating activity”

Added

protein-phosphatidylethanolamide deconjugating activity term tracker item “https://github.com/geneontology/go-ontology/issues/32575”^^anyURI
protein-phosphatidylethanolamide deconjugating activity database_cross_reference “RHEA:67548”
protein-phosphatidylethanolamide deconjugating activity has_narrow_synonym “APG8-PE hydrolase”
protein-phosphatidylethanolamide deconjugating activity has_narrow_synonym “Atg8-specific protease activity”
protein-phosphatidylethanolamide deconjugating activity exactMatch 67548
protein-phosphatidylethanolamide deconjugating activity definition “Catalysis of the reaction: [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine. An example of this reaction is the removal of ATG8 from membranes to which it is covalently linked to a phosphatidylethanolamine via its terminal glycine residue.”
- database_cross_reference “PMID:28330855”
- database_cross_reference “PMID:22240591”
- database_cross_reference “PMID:22652539”
- database_cross_reference “PMID:28821724”
- database_cross_reference “RHEA:67548”
- database_cross_reference “PMID:28901328”
protein-phosphatidylethanolamide deconjugating activity label “protein-phosphatidylethanolamine deconjugating activity”

protein-phosphocysteine-sugar phosphotransferase activity `http://purl.obolibrary.org/obo/GO_0090563`

Removed

protein-phosphocysteine-sugar phosphotransferase activity SubClassOf active transmembrane transporter activity

Added

protein-phosphocysteine-sugar phosphotransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/27496”^^anyURI
protein-phosphocysteine-sugar phosphotransferase activity SubClassOf group translocator activity

pteridine reductase activity `http://purl.obolibrary.org/obo/GO_0047040`

Removed

pteridine reductase activity has_narrow_synonym “pteridine reductase 1 activity”
- database_cross_reference “EC:1.5.1.33e”
pteridine reductase activity has_narrow_synonym “ptr1 activity”
- database_cross_reference “EC:1.5.1.33e”

Added

pteridine reductase activity has_narrow_synonym “pteridine reductase 1 activity”
- database_cross_reference “EC:1.5.1.33”
pteridine reductase activity has_narrow_synonym “ptr1 activity”
- database_cross_reference “EC:1.5.1.33”

purine-containing compound catabolic process `http://purl.obolibrary.org/obo/GO_0072523`

Removed

purine-containing compound catabolic process SubClassOf catabolic process

Added

purine-containing compound catabolic process SubClassOf nucleobase-containing small molecule catabolic process

pyridoxal 5’-phosphate synthase (glutamine hydrolysing) activity `http://purl.obolibrary.org/obo/GO_0036381`

Removed

pyridoxal 5’-phosphate synthase (glutamine hydrolysing) activity has_related_synonym “pyridoxal 5’-phosphate synthase (glutamine hydrolyzing) activity”
- database_cross_reference “EC:4.3.3.6”
pyridoxal 5’-phosphate synthase (glutamine hydrolysing) activity label “pyridoxal 5’-phosphate synthase (glutamine hydrolysing) activity”

Added

pyridoxal 5’-phosphate synthase (glutamine hydrolysing) activity has_related_synonym “pyridoxal 5’-phosphate synthase (glutamine hydrolysing) activity”
- database_cross_reference “EC:4.3.3.6”
pyridoxal 5’-phosphate synthase (glutamine hydrolysing) activity label “pyridoxal 5’-phosphate synthase (glutamine hydrolyzing) activity”

quinoprotein glucose dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0008876`

Removed

quinoprotein glucose dehydrogenase activity database_cross_reference “KEGG_REACTION:R00305”
quinoprotein glucose dehydrogenase activity database_cross_reference “MetaCyc:RXN0-6373”
quinoprotein glucose dehydrogenase activity database_cross_reference “RHEA:22152”
quinoprotein glucose dehydrogenase activity exactMatch 22152
quinoprotein glucose dehydrogenase activity definition “Catalysis of the reaction: D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol.”
- database_cross_reference “RHEA:22152”
quinoprotein glucose dehydrogenase activity label “quinoprotein glucose dehydrogenase activity”

Added

quinoprotein glucose dehydrogenase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32504”^^anyURI
quinoprotein glucose dehydrogenase activity has_broad_synonym “quinoprotein glucose dehydrogenase activity”
quinoprotein glucose dehydrogenase activity has_exact_synonym “quinoprotein glucose dehydrogenase (PQQ, quinone) activity”
quinoprotein glucose dehydrogenase activity broadMatch RXN0-6373
quinoprotein glucose dehydrogenase activity broadMatch 22152
quinoprotein glucose dehydrogenase activity broadMatch R06620
quinoprotein glucose dehydrogenase activity definition “Catalysis of the reaction: D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol, using PQQ as a cofactor.”
- database_cross_reference “EC:1.1.5.2”
quinoprotein glucose dehydrogenase activity label “glucose dehydrogenase (PQQ, quinone) activity”

rRNA (adenine-N6-)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0008988`

Removed

rRNA (adenine-N6-)-methyltransferase activity SubClassOf N-methyltransferase activity

Added

rRNA (adenine-N6-)-methyltransferase activity SubClassOf RNA (adenine-N6)-methyltransferase activity

receptor diffusion trapping `http://purl.obolibrary.org/obo/GO_0098953`

Removed

receptor diffusion trapping definition “The process by which a membrane receptor, diffusing freely within the plasma membeane, becomes trapped in some plasma membrane region. This can happen when a receptor bind, directly or indirectly, to some component of the underlying matrix.”
- database_cross_reference “PMID:18832033”

Added

receptor diffusion trapping definition “The process by which a membrane receptor, diffusing freely within the plasma membrane, becomes trapped in some plasma membrane region. This can happen when a receptor bind, directly or indirectly, to some component of the underlying matrix.”
- database_cross_reference “PMID:18832033”

regulation of ERAD pathway `http://purl.obolibrary.org/obo/GO_1904292`

Removed

regulation of ERAD pathway SubClassOf regulation of response to endoplasmic reticulum stress

regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process `http://purl.obolibrary.org/obo/GO_0062025`

Removed

regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process definition “Any process that modualtes the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.”
- database_cross_reference “PMID:28007894”

Added

regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process definition “Any process that modulates the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.”
- database_cross_reference “PMID:28007894”

regulation of axon extension `http://purl.obolibrary.org/obo/GO_0030516`

Removed

regulation of axon extension SubClassOf regulation of extent of cell growth

Added

regulation of axon extension term tracker item “https://github.com/geneontology/go-ontology/issues/19737”^^anyURI
regulation of axon extension SubClassOf regulation of cell growth

regulation of collateral sprouting `http://purl.obolibrary.org/obo/GO_0048670`

Removed

regulation of collateral sprouting SubClassOf regulation of extent of cell growth

Added

regulation of collateral sprouting term tracker item “https://github.com/geneontology/go-ontology/issues/19737”^^anyURI
regulation of collateral sprouting SubClassOf regulation of cell growth

regulation of cristae formation `http://purl.obolibrary.org/obo/GO_1903850`

Removed

regulation of cristae formation SubClassOf regulation of mitochondrion organization

Added

regulation of cristae formation SubClassOf regulation of cellular component organization

regulation of direction of cell growth `http://purl.obolibrary.org/obo/GO_0061389`

Removed

regulation of direction of cell growth definition “Any process that modulates the direction of cell growth.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:vw”

Added

regulation of direction of cell growth term tracker item “https://github.com/geneontology/go-ontology/issues/19737”^^anyURI
regulation of direction of cell growth definition “Any process that modulates where in a cell additional mass is added during cell growth.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:vw”

regulation of establishment of bipolar cell polarity regulating cell shape `http://purl.obolibrary.org/obo/GO_0061160`

Removed

regulation of establishment of bipolar cell polarity regulating cell shape definition “Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity that contributes to the shape of a cell.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:vw”
regulation of establishment of bipolar cell polarity regulating cell shape label “regulation of establishment of bipolar cell polarity regulating cell shape”
regulation of establishment of bipolar cell polarity regulating cell shape SubClassOf regulation of establishment of bipolar cell polarity
regulation of establishment of bipolar cell polarity regulating cell shape SubClassOf regulation of establishment or maintenance of bipolar cell polarity regulating cell shape

Added

regulation of establishment of bipolar cell polarity regulating cell shape term tracker item “https://github.com/geneontology/go-ontology/issues/21217”^^anyURI
regulation of establishment of bipolar cell polarity regulating cell shape term replaced by establishment or maintenance of bipolar cell polarity
regulation of establishment of bipolar cell polarity regulating cell shape definition “OBSOLETE. Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity that contributes to the shape of a cell.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:vw”
regulation of establishment of bipolar cell polarity regulating cell shape deprecated true
regulation of establishment of bipolar cell polarity regulating cell shape comment “The reason for obsoletion is that this term was made in error.”
regulation of establishment of bipolar cell polarity regulating cell shape label “obsolete regulation of establishment of bipolar cell polarity regulating cell shape”

regulation of establishment or maintenance of bipolar cell polarity regulating cell shape `http://purl.obolibrary.org/obo/GO_2000100`

Removed

regulation of establishment or maintenance of bipolar cell polarity regulating cell shape definition “Any process that modulates the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape.”
- database_cross_reference “GOC:obol”
regulation of establishment or maintenance of bipolar cell polarity regulating cell shape label “regulation of establishment or maintenance of bipolar cell polarity regulating cell shape”
regulation of establishment or maintenance of bipolar cell polarity regulating cell shape EquivalentTo biological regulation and (regulates some establishment or maintenance of bipolar cell polarity regulating cell shape)
regulation of establishment or maintenance of bipolar cell polarity regulating cell shape SubClassOf regulation of establishment or maintenance of bipolar cell polarity
regulation of establishment or maintenance of bipolar cell polarity regulating cell shape SubClassOf regulation of establishment or maintenance of cell polarity regulating cell shape
regulation of establishment or maintenance of bipolar cell polarity regulating cell shape SubClassOf regulates some establishment or maintenance of bipolar cell polarity regulating cell shape

Added

regulation of establishment or maintenance of bipolar cell polarity regulating cell shape term tracker item “https://github.com/geneontology/go-ontology/issues/21217”^^anyURI
regulation of establishment or maintenance of bipolar cell polarity regulating cell shape term replaced by establishment or maintenance of bipolar cell polarity
regulation of establishment or maintenance of bipolar cell polarity regulating cell shape definition “OBSOLETE. Any process that modulates the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape.”
- database_cross_reference “GOC:obol”
regulation of establishment or maintenance of bipolar cell polarity regulating cell shape deprecated true
regulation of establishment or maintenance of bipolar cell polarity regulating cell shape comment “The reason for obsoletion is that this term was made in error.”
regulation of establishment or maintenance of bipolar cell polarity regulating cell shape label “obsolete regulation of establishment or maintenance of bipolar cell polarity regulating cell shape”

regulation of extent of cell growth `http://purl.obolibrary.org/obo/GO_0061387`

Removed

regulation of extent of cell growth definition “Any process that modulates the extent of cell growth.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:vw”

Added

regulation of extent of cell growth term tracker item “https://github.com/geneontology/go-ontology/issues/19737”^^anyURI
regulation of extent of cell growth definition “Any process that modulates how much additional mass a cell adds during cell growth before growth ceases.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:vw”

regulation of glycolytic process `http://purl.obolibrary.org/obo/GO_0006110`

Removed

regulation of glycolytic process label “regulation of glycolytic process”

Added

regulation of glycolytic process term tracker item “https://github.com/geneontology/go-ontology/issues/32471”^^anyURI
regulation of glycolytic process has_exact_synonym “regulation of glycolytic process”
regulation of glycolytic process label “regulation of glycolysis”

regulation of maintenance of bipolar cell polarity regulating cell shape `http://purl.obolibrary.org/obo/GO_2000115`

Removed

regulation of maintenance of bipolar cell polarity regulating cell shape definition “Any process that modulates the frequency, rate or extent of maintenance of bipolar cell polarity regulating in cell shape.”
- database_cross_reference “GOC:obol”
regulation of maintenance of bipolar cell polarity regulating cell shape label “regulation of maintenance of bipolar cell polarity regulating cell shape”
regulation of maintenance of bipolar cell polarity regulating cell shape EquivalentTo biological regulation and (regulates some maintenance of bipolar cell polarity regulating cell shape)
regulation of maintenance of bipolar cell polarity regulating cell shape SubClassOf regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
regulation of maintenance of bipolar cell polarity regulating cell shape SubClassOf regulates some maintenance of bipolar cell polarity regulating cell shape

Added

regulation of maintenance of bipolar cell polarity regulating cell shape term tracker item “https://github.com/geneontology/go-ontology/issues/21217”^^anyURI
regulation of maintenance of bipolar cell polarity regulating cell shape term replaced by establishment or maintenance of bipolar cell polarity
regulation of maintenance of bipolar cell polarity regulating cell shape definition “OBSOLETE. Any process that modulates the frequency, rate or extent of maintenance of bipolar cell polarity regulating in cell shape.”
- database_cross_reference “GOC:obol”
regulation of maintenance of bipolar cell polarity regulating cell shape deprecated true
regulation of maintenance of bipolar cell polarity regulating cell shape comment “The reason for obsoletion is that this term was made in error.”
regulation of maintenance of bipolar cell polarity regulating cell shape label “obsolete regulation of maintenance of bipolar cell polarity regulating cell shape”

regulation of mitochondrial respiratory chain complex I assembly `http://purl.obolibrary.org/obo/GO_7770119`

Added

Class: regulation of mitochondrial respiratory chain complex I assembly
regulation of mitochondrial respiratory chain complex I assembly term tracker item “https://github.com/geneontology/go-ontology/issues/32577”^^anyURI
regulation of mitochondrial respiratory chain complex I assembly created by “ai4c-agent”
regulation of mitochondrial respiratory chain complex I assembly creation date “2026-09-11T00:23:26Z”
regulation of mitochondrial respiratory chain complex I assembly has_obo_namespace “biological_process”
regulation of mitochondrial respiratory chain complex I assembly id “GO:7770119”
regulation of mitochondrial respiratory chain complex I assembly definition “Any process that modulates the frequency, rate or extent of mitochondrial respiratory chain complex I assembly.”
- database_cross_reference “PMID:42361792”
regulation of mitochondrial respiratory chain complex I assembly label “regulation of mitochondrial respiratory chain complex I assembly”
regulation of mitochondrial respiratory chain complex I assembly EquivalentTo biological regulation and (regulates some mitochondrial respiratory chain complex I assembly)
regulation of mitochondrial respiratory chain complex I assembly SubClassOf regulation of protein-containing complex assembly
regulation of mitochondrial respiratory chain complex I assembly SubClassOf regulates some mitochondrial respiratory chain complex I assembly

regulation of protein localization to mitochondrion `http://purl.obolibrary.org/obo/GO_1903747`

Removed

regulation of protein localization to mitochondrion term tracker item “https://github.com/geneontology/go-ontology/issues/30349”^^anyURI
regulation of protein localization to mitochondrion definition “Any process that modulates the frequency, rate or extent of protein localization to mitochondrion.”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:16857185”
- database_cross_reference “GO_REF:0000058”
regulation of protein localization to mitochondrion label “regulation of protein localization to mitochondrion”
regulation of protein localization to mitochondrion EquivalentTo biological regulation and (regulates some protein localization to mitochondrion)
regulation of protein localization to mitochondrion SubClassOf regulation of protein localization
regulation of protein localization to mitochondrion SubClassOf regulates some protein localization to mitochondrion

Added

regulation of protein localization to mitochondrion term tracker item “https://github.com/geneontology/go-ontology/issues/32107”^^anyURI
regulation of protein localization to mitochondrion definition “OBSOLETE. Any process that modulates the frequency, rate or extent of protein localization to mitochondrion.”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:16857185”
- database_cross_reference “GO_REF:0000058”
regulation of protein localization to mitochondrion deprecated true
regulation of protein localization to mitochondrion comment “The reason for obsoletion is that this term represents a phenotype and was added in error. Consider annotating to regulation of the specific process being regulated (e.g. regulation of mitophagy) or to a specific mitochondrial protein import pathway; if the underlying evidence is a readout or a phenotype, or the mechanism is unclear, consider removal rather than re-annotation.”
regulation of protein localization to mitochondrion label “obsolete regulation of protein localization to mitochondrion”

regulation of rate of cell growth `http://purl.obolibrary.org/obo/GO_0061388`

Removed

regulation of rate of cell growth definition “Any process that modulates the rate of cell growth.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:vw”

Added

regulation of rate of cell growth term tracker item “https://github.com/geneontology/go-ontology/issues/19737”^^anyURI
regulation of rate of cell growth definition “Any process that modulates how fast a cell adds additional mass during cell growth.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:vw”

regulation of retrograde protein transport, ER to cytosol `http://purl.obolibrary.org/obo/GO_1904152`

Removed

regulation of retrograde protein transport, ER to cytosol definition “Any process that modulates the frequency, rate or extent of retrograde protein transport, ER to cytosol.”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:PARL”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:18555783”
- database_cross_reference “GO_REF:0000058”
regulation of retrograde protein transport, ER to cytosol label “regulation of retrograde protein transport, ER to cytosol”
regulation of retrograde protein transport, ER to cytosol EquivalentTo biological regulation and (regulates some retrograde protein transport, ER to cytosol)
regulation of retrograde protein transport, ER to cytosol SubClassOf regulation of protein transport
regulation of retrograde protein transport, ER to cytosol SubClassOf regulates some retrograde protein transport, ER to cytosol

Added

regulation of retrograde protein transport, ER to cytosol term tracker item “https://github.com/geneontology/go-ontology/issues/32525”^^anyURI
regulation of retrograde protein transport, ER to cytosol term replaced by ERAD pathway
regulation of retrograde protein transport, ER to cytosol definition “OBSOLETE. Any process that modulates the frequency, rate or extent of retrograde protein transport, ER to cytosol.”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:PARL”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:18555783”
- database_cross_reference “GO_REF:0000058”
regulation of retrograde protein transport, ER to cytosol deprecated true
regulation of retrograde protein transport, ER to cytosol comment “The reason for obsoletion is that the term is not clearly defined and usage has been inconsistent, the data from the paper for which the term was requested can be accurately described using reguation of ERAD pathway terms, and this term was added in error.”
regulation of retrograde protein transport, ER to cytosol label “obsolete regulation of retrograde protein transport, ER to cytosol”

regulation of sprouting of injured axon `http://purl.obolibrary.org/obo/GO_0048686`

Removed

regulation of sprouting of injured axon SubClassOf regulation of extent of cell growth

Added

regulation of sprouting of injured axon term tracker item “https://github.com/geneontology/go-ontology/issues/19737”^^anyURI
regulation of sprouting of injured axon SubClassOf regulation of cell growth

regulation of sulfate assimilation `http://purl.obolibrary.org/obo/GO_1900058`

Added

regulation of sulfate assimilation SubClassOf regulation of small molecule metabolic process

regulation of transcription by RNA polymerase III `http://purl.obolibrary.org/obo/GO_0006359`

Removed

regulation of transcription by RNA polymerase III definition “Any process that modulates the frequency, rate or extent of transcription mediated by RNA ploymerase III.”
- database_cross_reference “GOC:curators”

Added

regulation of transcription by RNA polymerase III definition “Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase III.”
- database_cross_reference “GOC:curators”

regulation of transcription from RNA polymerase II promoter by galactose `http://purl.obolibrary.org/obo/GO_0000431`

Removed

regulation of transcription from RNA polymerase II promoter by galactose definition “Any process involving galactose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.”
- database_cross_reference “GOC:krc”
regulation of transcription from RNA polymerase II promoter by galactose label “regulation of transcription from RNA polymerase II promoter by galactose”
regulation of transcription from RNA polymerase II promoter by galactose SubClassOf regulation of transcription by galactose
regulation of transcription from RNA polymerase II promoter by galactose SubClassOf carbon catabolite regulation of transcription from RNA polymerase II promoter

Added

regulation of transcription from RNA polymerase II promoter by galactose term tracker item “https://github.com/geneontology/go-ontology/issues/21442”^^anyURI
regulation of transcription from RNA polymerase II promoter by galactose consider regulation of transcription by RNA polymerase II
regulation of transcription from RNA polymerase II promoter by galactose definition “OBSOLETE. Any process involving galactose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.”
- database_cross_reference “GOC:krc”
regulation of transcription from RNA polymerase II promoter by galactose deprecated true
regulation of transcription from RNA polymerase II promoter by galactose comment “The reason for obsoletion is that these terms represent GO-CAM models.”
regulation of transcription from RNA polymerase II promoter by galactose label “obsolete regulation of transcription from RNA polymerase II promoter by galactose”

regulation of transcription from RNA polymerase II promoter by glucose `http://purl.obolibrary.org/obo/GO_0000430`

Removed

regulation of transcription from RNA polymerase II promoter by glucose definition “Any process involving glucose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.”
- database_cross_reference “GOC:krc”
regulation of transcription from RNA polymerase II promoter by glucose label “regulation of transcription from RNA polymerase II promoter by glucose”
regulation of transcription from RNA polymerase II promoter by glucose SubClassOf carbon catabolite regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter by glucose SubClassOf regulation of transcription by glucose

Added

regulation of transcription from RNA polymerase II promoter by glucose term tracker item “https://github.com/geneontology/go-ontology/issues/21442”^^anyURI
regulation of transcription from RNA polymerase II promoter by glucose consider regulation of transcription by RNA polymerase II
regulation of transcription from RNA polymerase II promoter by glucose definition “OBSOLETE. Any process involving glucose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.”
- database_cross_reference “GOC:krc”
regulation of transcription from RNA polymerase II promoter by glucose deprecated true
regulation of transcription from RNA polymerase II promoter by glucose comment “The reason for obsoletion is that these terms represent GO-CAM models.”
regulation of transcription from RNA polymerase II promoter by glucose label “obsolete regulation of transcription from RNA polymerase II promoter by glucose”

regulatory ncRNA-mediated heterochromatin formation `http://purl.obolibrary.org/obo/GO_0031048`

Removed

regulatory ncRNA-mediated heterochromatin formation definition “A heterochromatin formation-based gene silencing process mediated by a regulatory non-coding RNA molecule that occur before the beginning of trancription.”
- database_cross_reference “PMID:19239886”
- database_cross_reference “PMID:21420348”

Added

regulatory ncRNA-mediated heterochromatin formation definition “A heterochromatin formation-based gene silencing process mediated by a regulatory non-coding RNA molecule that occurs before the beginning of transcription.”
- database_cross_reference “PMID:19239886”
- database_cross_reference “PMID:21420348”

replicative senescence `http://purl.obolibrary.org/obo/GO_0090399`

Removed

replicative senescence definition “The process by which normal somatic cells reach an irreversible stage of cell cycle arrest following multiple rounds of replication; this end stage is associated with marked changes in gene expression and function. This is a natural barrier to unlimited proliferation of somatic cells, and is believed to be contolled by telomere shortening.”
- database_cross_reference “PMID:23061726”
- database_cross_reference “PMID:17014937”

Added

replicative senescence definition “The process by which normal somatic cells reach an irreversible stage of cell cycle arrest following multiple rounds of replication; this end stage is associated with marked changes in gene expression and function. This is a natural barrier to unlimited proliferation of somatic cells, and is believed to be controlled by telomere shortening.”
- database_cross_reference “PMID:23061726”
- database_cross_reference “PMID:17014937”

rescue of stalled mitochondrial ribosome `http://purl.obolibrary.org/obo/GO_7770016`

Removed

rescue of stalled mitochondrial ribosome SubClassOf rescue of stalled cytosolic ribosome

Added

rescue of stalled mitochondrial ribosome term tracker item “https://github.com/geneontology/go-ontology/issues/26238”^^anyURI
rescue of stalled mitochondrial ribosome SubClassOf ribosome disassembly

respiratory burst after phagocytosis `http://purl.obolibrary.org/obo/GO_0045728`

Added

respiratory burst after phagocytosis term tracker item “https://github.com/geneontology/go-ontology/issues/32152”^^anyURI

response to interleukin-5 `http://purl.obolibrary.org/obo/GO_7770102`

Added

Class: response to interleukin-5
response to interleukin-5 term tracker item “https://github.com/geneontology/go-ontology/issues/32411”^^anyURI
response to interleukin-5 created by “ai4c-agent”
response to interleukin-5 creation date “2026-08-04T23:16:15Z”
response to interleukin-5 has_exact_synonym “response to IL-5”
response to interleukin-5 has_obo_namespace “biological_process”
response to interleukin-5 id “GO:7770102”
response to interleukin-5 definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-5 stimulus.”
- database_cross_reference “PMID:41207640”
response to interleukin-5 label “response to interleukin-5”
response to interleukin-5 SubClassOf response to cytokine

response to mitochondrial depolarisation `http://purl.obolibrary.org/obo/GO_0098780`

Removed

response to mitochondrial depolarisation label “response to mitochondrial depolarisation”

Added

response to mitochondrial depolarisation label “response to mitochondrial depolarization”

retrograde trans-synaptic signaling by endocannabinoid `http://purl.obolibrary.org/obo/GO_0098921`

Added

retrograde trans-synaptic signaling by endocannabinoid term tracker item “https://github.com/geneontology/go-ontology/issues/20574”^^anyURI

retrotransposition `http://purl.obolibrary.org/obo/GO_0032197`

Removed

retrotransposition definition “A type of transposition in which a transposable element (transposon) copies and pastes itself into a different genomic location by transcription and convertsion of the transcribed RNA back into DNA through reverse transcription.”
- database_cross_reference “ISBN:1555812090”
- database_cross_reference “PMID:32588192”
- database_cross_reference “PMID:26912865”
- database_cross_reference “PMID:30416149”
- database_cross_reference “PMID:30958115”

Added

retrotransposition definition “A type of transposition in which a transposable element (transposon) copies and pastes itself into a different genomic location by transcription and conversion of the transcribed RNA back into DNA through reverse transcription.”
- database_cross_reference “ISBN:1555812090”
- database_cross_reference “PMID:32588192”
- database_cross_reference “PMID:26912865”
- database_cross_reference “PMID:30416149”
- database_cross_reference “PMID:30958115”

riboflavin kinase activity `http://purl.obolibrary.org/obo/GO_0008531`

Removed

riboflavin kinase activity definition “Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H+.”
- database_cross_reference “EC:2.7.1.26”
- database_cross_reference “RHEA:14357”

Added

riboflavin kinase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32345”^^anyURI
riboflavin kinase activity definition “Catalysis of the reaction: riboflavin + ATP = FMN + ADP + H+.”
- database_cross_reference “RHEA:14357”

ribosome-associated chaperone complex `http://purl.obolibrary.org/obo/GO_0170081`

Added

Class: ribosome-associated chaperone complex
ribosome-associated chaperone complex term tracker item “https://github.com/geneontology/go-ontology/issues/32185”^^anyURI
ribosome-associated chaperone complex created by “ew”
ribosome-associated chaperone complex creation date “2026-08-20T20:04:20Z”
ribosome-associated chaperone complex has_narrow_synonym “MPP11/Hsp70L1 complex”
ribosome-associated chaperone complex has_narrow_synonym “Zuo1/Ssz1 complex”
ribosome-associated chaperone complex has_narrow_synonym “zuotin complex”
ribosome-associated chaperone complex has_obo_namespace “cellular_component”
ribosome-associated chaperone complex has_related_synonym “RAC”
ribosome-associated chaperone complex has_related_synonym “ribosome-associated complex”
ribosome-associated chaperone complex id “GO:0170081”
ribosome-associated chaperone complex definition “A conserved heterodimeric co-chaperone complex, composed of a J-domain (Hsp40-family) protein and an atypical Hsp70-family protein, that associates with the ribosome and acts on nascent polypeptide chains as they emerge from the exit tunnel to enable their co-translational folding. In Saccharomyces cerevisiae, the complex consists of the J-domain protein Zuo1 (Hsp40) and the non-canonical Hsp70 homolog Ssz1. The mammalian ortholog comprises ZRF1/MPP11 (Hsp40) and HSPA14/HSP70L1 (Hsp70).”
- database_cross_reference “PMID:11274393”
- database_cross_reference “PMID:16002468”
ribosome-associated chaperone complex comment “Note that this term does not cover the nascent polypeptide-associated complex (GO:0005854), a distinct ribosome-associated heterodimer that acts in nascent chain sorting rather than folding.”
ribosome-associated chaperone complex label “ribosome-associated chaperone complex”
ribosome-associated chaperone complex SubClassOf protein folding chaperone complex
ribosome-associated chaperone complex SubClassOf part of some cytosol

ribosome-associated quality control `http://purl.obolibrary.org/obo/GO_7770112`

Added

Class: ribosome-associated quality control
ribosome-associated quality control term tracker item “https://github.com/geneontology/go-ontology/issues/18610”^^anyURI
ribosome-associated quality control term tracker item “https://github.com/geneontology/go-ontology/issues/26238”^^anyURI
ribosome-associated quality control term tracker item “https://github.com/geneontology/go-ontology/issues/32546”^^anyURI
ribosome-associated quality control created by “ai4c-agent”
ribosome-associated quality control creation date “2026-08-18T05:06:46Z”
ribosome-associated quality control has_exact_synonym “RQC”
ribosome-associated quality control has_exact_synonym “ribosome quality control”
ribosome-associated quality control has_obo_namespace “biological_process”
ribosome-associated quality control id “GO:7770112”
ribosome-associated quality control has_exact_synonym “ribosome-associated protein quality control”
- database_cross_reference “PMID:26733220”
ribosome-associated quality control definition “A protein quality control pathway that acts on ribosomes stalled during translation to target the incomplete nascent polypeptide chain for degradation.”
- database_cross_reference “PMID:35452614”
- database_cross_reference “PMID:34233554”
- database_cross_reference “PMID:32569528”
ribosome-associated quality control comment “The core RQC machinery (NEMF/Rqc2/RqcH and the associated untemplated C-terminal chain elongation) is conserved from bacteria to humans, so this term is not restricted to eukaryotes.”
ribosome-associated quality control label “ribosome-associated quality control”
ribosome-associated quality control SubClassOf protein quality control for misfolded or incompletely synthesized proteins
ribosome-associated quality control SubClassOf has part some protein catabolic process

ribosome-associated ubiquitin-dependent protein catabolic process `http://purl.obolibrary.org/obo/GO_1990116`

Added

ribosome-associated ubiquitin-dependent protein catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/26238”^^anyURI
ribosome-associated ubiquitin-dependent protein catabolic process SubClassOf part of some ribosome-associated quality control

ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity `http://purl.obolibrary.org/obo/GO_0046863`

Removed

ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity definition “Binds to and iincreases the activity of rubisco by the removal of otherwise inhibitory sugar phosphates: RuBP, and in some plants, 2-carboxyarabinitol 1-phosphate.”
- database_cross_reference “PMID:10430961”
- database_cross_reference “PMID:10965036”
- database_cross_reference “PMID:2404515”

Added

ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity definition “Binds to and increases the activity of rubisco by the removal of otherwise inhibitory sugar phosphates: RuBP, and in some plants, 2-carboxyarabinitol 1-phosphate.”
- database_cross_reference “PMID:10430961”
- database_cross_reference “PMID:10965036”
- database_cross_reference “PMID:2404515”

segment polarity determination `http://purl.obolibrary.org/obo/GO_0007367`

Removed

segment polarity determination definition “Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products.”
- database_cross_reference “ISBN:0632030488”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

segment polarity determination term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
segment polarity determination definition “Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products.”
- database_cross_reference “ISBN:0632030488”
- database_cross_reference “ISBN:0879694238”

segment specification `http://purl.obolibrary.org/obo/GO_0007379`

Removed

segment specification definition “The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

segment specification term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
segment specification definition “The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes.”
- database_cross_reference “ISBN:0879694238”

serotonin-gated cation-selective signaling pathway `http://purl.obolibrary.org/obo/GO_0140227`

Removed

serotonin-gated cation-selective signaling pathway definition “The series of molecular signals initiated by serotonin binding to a seratonin receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription.”
- database_cross_reference “GOC:bhm”
- database_cross_reference “PMID:27764665”
- database_cross_reference “PMID:25392484”

Added

serotonin-gated cation-selective signaling pathway definition “The series of molecular signals initiated by serotonin binding to a serotonin receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription.”
- database_cross_reference “GOC:bhm”
- database_cross_reference “PMID:27764665”
- database_cross_reference “PMID:25392484”

seryl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0006434`

Removed

seryl-tRNA aminoacylation definition “The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3’-OH group of a serine-accetping tRNA.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
seryl-tRNA aminoacylation label “seryl-tRNA aminoacylation”
seryl-tRNA aminoacylation SubClassOf tRNA aminoacylation for protein translation
seryl-tRNA aminoacylation SubClassOf has part some conversion of seryl-tRNAsec to selenocys-tRNAsec

Added

seryl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
seryl-tRNA aminoacylation term replaced by tRNA aminoacylation for protein translation
seryl-tRNA aminoacylation definition “OBSOLETE. The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3’-OH group of a serine-accetping tRNA.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
seryl-tRNA aminoacylation deprecated true
seryl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004828 serine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0006418 tRNA aminoacylation for protein translation.”
seryl-tRNA aminoacylation label “obsolete seryl-tRNA aminoacylation”

sex comb development `http://purl.obolibrary.org/obo/GO_0045498`

Removed

sex comb development definition “The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg.”
- database_cross_reference “http://fly.ebi.ac.uk”

Added

sex comb development term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
sex comb development definition “The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg.”
- database_cross_reference “FBbt:00004296”

snRNA 2,2,7-trimethylguanosine (TMG) capping `http://purl.obolibrary.org/obo/GO_1990273`

Removed

snRNA 2,2,7-trimethylguanosine (TMG) capping definition “The sequence of enzymatic reactions by which a 2,2,7-trimethylguanosine cap structure is added to the 5’ end of an snRNA. The snRNA capping process includes the formation of 7-methyl-G caps found on all RNA polymerase II transcripts, followed by hypermethylation at the 2’ position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. Note that the pol III transcribed U6 snRNA is also TMG capped.”
- database_cross_reference “PMID:15590684”
- database_cross_reference “GOC:vw”

Added

snRNA 2,2,7-trimethylguanosine (TMG) capping term tracker item “https://github.com/geneontology/go-ontology/issues/27628”^^anyURI
snRNA 2,2,7-trimethylguanosine (TMG) capping definition “The sequence of enzymatic reactions by which a 2,2,7-trimethylguanosine (TMG) cap structure is added to the 5’ end of an snRNA. The process begins with the formation of a 7-methylguanosine cap, as found on all RNA polymerase II transcripts, followed by dimethylation at the N2 position of the guanine base to convert the monomethylated cap to a 2,2,7-trimethylguanosine cap structure.”
- database_cross_reference “PMID:15590684”
- database_cross_reference “GOC:vw”
- database_cross_reference “PMID:11142384”
snRNA 2,2,7-trimethylguanosine (TMG) capping comment “TMG capped snRNAs are RNA polymerase II transcripts. The RNA polymerase III transcribed U6 snRNA is not TMG capped; it carries a gamma-monomethyl phosphate cap added by the Bin3/MePCE family of methylphosphate capping enzymes (PMID:2229067, PMID:37403782). TMG capping of a Pol III transcript has been reported only for engineered U6 variants in which disruption of the 5’ stem-loop exposes the 5’-triphosphate to the normal methylguanosine capping machinery (PMID:11142384).”
snRNA 2,2,7-trimethylguanosine (TMG) capping SubClassOf has part some 7-methylguanosine RNA capping
snRNA 2,2,7-trimethylguanosine (TMG) capping SubClassOf has part some 7-methylguanosine cap hypermethylation

snoRNA 2,2,7-trimethylguanosine (TMG) capping `http://purl.obolibrary.org/obo/GO_0180031`

Removed

snoRNA 2,2,7-trimethylguanosine (TMG) capping definition “The sequence of enzymatic reactions by which a 2,2,7-trimethylguanosine cap structure is added to the 5’ end of an snoRNA. The snoRNA capping includes the formation of 7-methyl-G caps found on all RNA polymerase II transcripts, followed by hypermethylation at the 2’ position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. Note that the pol III transcribed snoRNAs are also TMG capped.”
- database_cross_reference “PMID:15590684”
- database_cross_reference “GOC:vw”

Added

snoRNA 2,2,7-trimethylguanosine (TMG) capping term tracker item “https://github.com/geneontology/go-ontology/issues/27628”^^anyURI
snoRNA 2,2,7-trimethylguanosine (TMG) capping definition “The sequence of enzymatic reactions by which a 2,2,7-trimethylguanosine (TMG) cap structure is added to the 5’ end of an snoRNA. The process begins with the formation of a 7-methylguanosine cap, as found on all RNA polymerase II transcripts, followed by dimethylation at the N2 position of the guanine base to convert the monomethylated cap to a 2,2,7-trimethylguanosine cap structure.”
- database_cross_reference “PMID:15590684”
- database_cross_reference “PMID:11983179”
- database_cross_reference “GOC:vw”
snoRNA 2,2,7-trimethylguanosine (TMG) capping comment “TMG capped snoRNAs are RNA polymerase II transcripts. Where a snoRNA is transcribed by RNA polymerase III it is not TMG capped: plant U3 snoRNA, which is Pol III transcribed, carries a gamma-monomethyl phosphate cap, whereas the same snoRNA is TMG capped in the animals and fungi where it is Pol II transcribed (PMID:1618872).”
snoRNA 2,2,7-trimethylguanosine (TMG) capping SubClassOf has part some 7-methylguanosine RNA capping
snoRNA 2,2,7-trimethylguanosine (TMG) capping SubClassOf has part some 7-methylguanosine cap hypermethylation

spongiome `http://purl.obolibrary.org/obo/GO_0062160`

Removed

spongiome definition “A cellular anatomical entity which is a network of tubules and vessicles and is part of the contractile vacuole complex. It is involved in the discharge of water externally. One of its functions is osmoregulatory.”
- database_cross_reference “PMID:23890380”

Added

spongiome definition “A cellular anatomical entity which is a network of tubules and vesicles and is part of the contractile vacuole complex. It is involved in the discharge of water externally. One of its functions is osmoregulatory.”
- database_cross_reference “PMID:23890380”

substrate localization to autophagosome `http://purl.obolibrary.org/obo/GO_0061753`

Removed

substrate localization to autophagosome definition “The localization process by which an autophagic substrate is delivered to a forming autophagosome.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:PARL”
- database_cross_reference “GOC:pad”
- database_cross_reference “PMID:23545414”
substrate localization to autophagosome label “substrate localization to autophagosome”
substrate localization to autophagosome SubClassOf establishment of localization in cell
substrate localization to autophagosome SubClassOf part of some autophagosome assembly

Added

substrate localization to autophagosome term tracker item “https://github.com/geneontology/go-ontology/issues/32304”^^anyURI
substrate localization to autophagosome definition “OBSOLETE. The localization process by which an autophagic substrate is delivered to a forming autophagosome.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:PARL”
- database_cross_reference “GOC:pad”
- database_cross_reference “PMID:23545414”
substrate localization to autophagosome deprecated true
substrate localization to autophagosome comment “The reason for obsoletion is that this term was an unnecessary grouping term: localization terms that are not transport terms are largely uninformative about biological process. The intended biology in every observed use is better captured by a specific selective-autophagy term (e.g. mitophagy, glycophagy, reticulophagy). See the annotation review at https://github.com/geneontology/go-annotation/issues/6497 for per-annotation transfer recommendations.”
substrate localization to autophagosome label “obsolete substrate localization to autophagosome”

subtelomeric heterochromatin formation `http://purl.obolibrary.org/obo/GO_0031509`

Removed

subtelomeric heterochromatin formation SubClassOf occurs in some chromosome, telomeric region

Added

subtelomeric heterochromatin formation term tracker item “https://github.com/geneontology/go-ontology/issues/32403”^^anyURI

sulfate assimilation `http://purl.obolibrary.org/obo/GO_0000103`

Added

sulfate assimilation term tracker item “https://github.com/geneontology/go-ontology/issues/32287”^^anyURI
sulfate assimilation term tracker item “https://github.com/geneontology/go-ontology/issues/32376”^^anyURI
sulfate assimilation SubClassOf small molecule metabolic process
sulfate assimilation SubClassOf nutrient assimilation

symbiont-mediated perturbation of host actin cytoskeleton via actin filament reorganization `http://purl.obolibrary.org/obo/GO_0141032`

Removed

symbiont-mediated perturbation of host actin cytoskeleton via actin filament reorganization definition “The process in which an organism effects a change that impairs the structure or function of the host actin cytoskeleton by reorganizing the actin filaments, in a way that keeps the total filementous actin remains approximately constant. The host is defined as the larger of the organisms involved in a symbiotic interaction.”
- database_cross_reference “PMID:22212282”
- database_cross_reference “PMID:31130928”

Added

symbiont-mediated perturbation of host actin cytoskeleton via actin filament reorganization definition “The process in which an organism effects a change that impairs the structure or function of the host actin cytoskeleton by reorganizing the actin filaments, in a way that keeps the total filamentous actin approximately constant. The host is defined as the larger of the organisms involved in a symbiotic interaction.”
- database_cross_reference “PMID:22212282”
- database_cross_reference “PMID:31130928”

symmetric synapse `http://purl.obolibrary.org/obo/GO_0032280`

Removed

symmetric synapse definition “A synapse that lacks an electron dense postsynaptic specialization. In vertebtrates, these occur primarily on dendrite shafts and neuronal cell bodies and involve persynapses containing clusters of predominantly flattened or elongated vesicles and are typically inhibitory.”
- database_cross_reference “GOC:dgh”
- database_cross_reference “GOC:ef”

Added

symmetric synapse definition “A synapse that lacks an electron dense postsynaptic specialization. In vertebrates, these occur primarily on dendrite shafts and neuronal cell bodies and involve presynapses containing clusters of predominantly flattened or elongated vesicles and are typically inhibitory.”
- database_cross_reference “GOC:dgh”
- database_cross_reference “GOC:ef”

tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0043039`

Removed

tRNA aminoacylation has_exact_synonym “tRNA charging”
tRNA aminoacylation label “tRNA aminoacylation”
tRNA aminoacylation SubClassOf amino acid activation

Added

tRNA aminoacylation has_exact_synonym “aminoacyl tRNA synthesis”
tRNA aminoacylation has_exact_synonym “tRNA aminoacylation”
tRNA aminoacylation label “tRNA charging”

tRNA aminoacylation for nonribosomal peptide biosynthetic process `http://purl.obolibrary.org/obo/GO_0043040`

Removed

tRNA aminoacylation for nonribosomal peptide biosynthetic process SubClassOf amino acid activation for nonribosomal peptide biosynthetic process

Added

tRNA aminoacylation for nonribosomal peptide biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
tRNA aminoacylation for nonribosomal peptide biosynthetic process SubClassOf part of some nonribosomal peptide biosynthetic process

tRNA aminoacylation for protein translation `http://purl.obolibrary.org/obo/GO_0006418`

Removed

tRNA aminoacylation for protein translation has_narrow_synonym “tRNA charging”

tRNA(Val) (adenine(37)-N6)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_7770054`

Removed

tRNA(Val) (adenine(37)-N6)-methyltransferase activity SubClassOf N-methyltransferase activity

Added

tRNA(Val) (adenine(37)-N6)-methyltransferase activity SubClassOf RNA (adenine-N6)-methyltransferase activity

terminal region determination `http://purl.obolibrary.org/obo/GO_0007362`

Removed

terminal region determination definition “Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

terminal region determination term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
terminal region determination definition “Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products.”
- database_cross_reference “ISBN:0879694238”

tetrahydrofolate interconversion `http://purl.obolibrary.org/obo/GO_0035999`

Removed

tetrahydrofolate interconversion has_exact_synonym “folate cycle”
tetrahydrofolate interconversion definition “The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesize other tetrahydrofolate molecules.”
- database_cross_reference “GOC:yaf”
- database_cross_reference “PMID:1825999”
tetrahydrofolate interconversion label “tetrahydrofolate interconversion”

Added

tetrahydrofolate interconversion term tracker item “https://github.com/geneontology/go-ontology/issues/32362”^^anyURI
tetrahydrofolate interconversion has_exact_synonym “folate-mediated one-carbon metabolism”
tetrahydrofolate interconversion has_exact_synonym “folic acid cycle”
tetrahydrofolate interconversion has_exact_synonym “tetrahydrofolate interconversion”
tetrahydrofolate interconversion definition “A cyclic series of interconversions of the one-carbon unit carried by tetrahydrofolate - as 10-formyltetrahydrofolate, 5,10-methenyltetrahydrofolate, 5,10-methylenetetrahydrofolate and 5-methyltetrahydrofolate. Couples the acquisition of a one-carbon unit from donors such as serine, glycine or formate with its transfer, in the appropriate oxidation state, to biosynthetic acceptors, and with regeneration of tetrahydrofolate.”
- database_cross_reference “PMID:18804690”
- database_cross_reference “PMID:27641100”
- database_cross_reference “PMID:1825999”
tetrahydrofolate interconversion label “folate cycle”

thioredoxin peroxidase activity `http://purl.obolibrary.org/obo/GO_0008379`

Removed

thioredoxin peroxidase activity database_cross_reference “MetaCyc:RXN0-267”
thioredoxin peroxidase activity database_cross_reference “RHEA:63528”
thioredoxin peroxidase activity exactMatch 63528
thioredoxin peroxidase activity definition “Catalysis of the reaction: [thioredoxin]-dithiol + H2O2 = [thioredoxin]-disulfide + H2O.”
- database_cross_reference “RHEA:63528”
thioredoxin peroxidase activity label “thioredoxin peroxidase activity”
thioredoxin peroxidase activity SubClassOf thioredoxin-dependent peroxiredoxin activity

Added

thioredoxin peroxidase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32388”^^anyURI
thioredoxin peroxidase activity term replaced by thioredoxin-dependent peroxiredoxin activity
thioredoxin peroxidase activity definition “OBSOLETE. Catalysis of the reaction: [thioredoxin]-dithiol + H2O2 = [thioredoxin]-disulfide + H2O.”
- database_cross_reference “RHEA:63528”
thioredoxin peroxidase activity deprecated true
thioredoxin peroxidase activity comment “This term was obsoleted because it is redundant with GO:0140824 thioredoxin-dependent peroxiredoxin activity. Both enzyme activities use thioredoxin; the nominal distinction was that GO:0008379/RHEA:63528 specified hydrogen peroxide as substrate while GO:0140824/RHEA:62620 uses a hydroperoxide (of which H2O2 is a subtype). RHEA:63528 has no proteins associated with it and this term has been misannotated for enzymes with broader hydroperoxide specificity.”
thioredoxin peroxidase activity label “obsolete thioredoxin peroxidase activity”

thioredoxin-dependent peroxiredoxin activity `http://purl.obolibrary.org/obo/GO_0140824`

Added

thioredoxin-dependent peroxiredoxin activity term tracker item “https://github.com/geneontology/go-ontology/issues/32388”^^anyURI
thioredoxin-dependent peroxiredoxin activity database_cross_reference “MetaCyc:RXN0-267”
thioredoxin-dependent peroxiredoxin activity database_cross_reference “RHEA:63528”
thioredoxin-dependent peroxiredoxin activity has_exact_synonym “TPx activity”
thioredoxin-dependent peroxiredoxin activity has_exact_synonym “TrxPx activity”
thioredoxin-dependent peroxiredoxin activity has_exact_synonym “thioredoxin peroxidase activity”
thioredoxin-dependent peroxiredoxin activity has_related_synonym “thiol peroxidase activity”
thioredoxin-dependent peroxiredoxin activity narrowMatch RXN0-267
thioredoxin-dependent peroxiredoxin activity narrowMatch 63528

thorax and anterior abdomen determination `http://purl.obolibrary.org/obo/GO_0007356`

Removed

thorax and anterior abdomen determination definition “Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

thorax and anterior abdomen determination term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
thorax and anterior abdomen determination definition “Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product.”
- database_cross_reference “ISBN:0879694238”

threonyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0006435`

Removed

threonyl-tRNA aminoacylation definition “The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3’-OH group of a threonine-accetping tRNA.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
threonyl-tRNA aminoacylation label “threonyl-tRNA aminoacylation”
threonyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for protein translation

Added

threonyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
threonyl-tRNA aminoacylation term replaced by tRNA aminoacylation for protein translation
threonyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3’-OH group of a threonine-accetping tRNA.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
threonyl-tRNA aminoacylation deprecated true
threonyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004829 threonine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0006418 tRNA aminoacylation for protein translation.”
threonyl-tRNA aminoacylation label “obsolete threonyl-tRNA aminoacylation”

trans-synaptic signaling by endocannabinoid `http://purl.obolibrary.org/obo/GO_0099542`

Added

trans-synaptic signaling by endocannabinoid term tracker item “https://github.com/geneontology/go-ontology/issues/20574”^^anyURI

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission `http://purl.obolibrary.org/obo/GO_0099553`

Added

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission term tracker item “https://github.com/geneontology/go-ontology/issues/20574”^^anyURI

transcription elongation by mitochondrial RNA polymerase `http://purl.obolibrary.org/obo/GO_0006392`

Removed

transcription elongation by mitochondrial RNA polymerase definition “The extension of an RNA molecule after transcription initiation and promoter clearance at mitochondrial promoter by the addition of ribonucleotides catalyzed by a mitchondrial RNA polymerase.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:txnOH”

Added

transcription elongation by mitochondrial RNA polymerase definition “The extension of an RNA molecule after transcription initiation and promoter clearance at mitochondrial promoter by the addition of ribonucleotides catalyzed by a mitochondrial RNA polymerase.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:txnOH”

transport-coupled glycolytic process through glucose-6-phosphate `http://purl.obolibrary.org/obo/GO_0061633`

Removed

transport-coupled glycolytic process through glucose-6-phosphate database_cross_reference “MetaCyc:GLYCOLYSIS”
transport-coupled glycolytic process through glucose-6-phosphate definition “The chemical reactions and pathways resulting in the breakdown of glucose into pyruvate, in which the glucose is converted to glucose-6-phosphate intermediate coupled to transmembrane transport.”
- database_cross_reference “GOC:dph”
transport-coupled glycolytic process through glucose-6-phosphate label “transport-coupled glycolytic process through glucose-6-phosphate”
transport-coupled glycolytic process through glucose-6-phosphate SubClassOf glucose catabolic process
transport-coupled glycolytic process through glucose-6-phosphate SubClassOf glycolytic process through glucose-6-phosphate
transport-coupled glycolytic process through glucose-6-phosphate SubClassOf has part some protein-N(PI)-phosphohistidine-glucose phosphotransferase system transporter activity

Added

transport-coupled glycolytic process through glucose-6-phosphate term tracker item “https://github.com/geneontology/go-ontology/issues/32471”^^anyURI
transport-coupled glycolytic process through glucose-6-phosphate term replaced by glycolytic process
transport-coupled glycolytic process through glucose-6-phosphate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glucose into pyruvate, in which the glucose is converted to glucose-6-phosphate intermediate coupled to transmembrane transport.”
- database_cross_reference “GOC:dph”
transport-coupled glycolytic process through glucose-6-phosphate deprecated true
transport-coupled glycolytic process through glucose-6-phosphate comment “The reason for obsoletion is that this term represents a GO-CAM model.”
transport-coupled glycolytic process through glucose-6-phosphate label “obsolete transport-coupled glycolytic process through glucose-6-phosphate”

transporter activity `http://purl.obolibrary.org/obo/GO_0005215`

Removed

transporter activity definition “Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells.”
- database_cross_reference “GOC:dgf”
- database_cross_reference “GOC:ai”

Added

transporter activity definition “Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, across or in between cells.”
- database_cross_reference “GOC:dgf”
- database_cross_reference “GOC:ai”

tricetin O-methytransferase activity `http://purl.obolibrary.org/obo/GO_0102146`

Removed

tricetin O-methytransferase activity label “tricetin O-methytransferase activity”

Added

tricetin O-methytransferase activity label “tricetin O-methyltransferase activity”

tripartite regional subdivision `http://purl.obolibrary.org/obo/GO_0007351`

Removed

tripartite regional subdivision definition “Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:isa_complete”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

tripartite regional subdivision term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
tripartite regional subdivision definition “Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:isa_complete”
- database_cross_reference “ISBN:0879694238”

tryptophanyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0006436`

Removed

tryptophanyl-tRNA aminoacylation definition “The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2’-OH group of a tryptophan-accetping tRNA. The 2’-O-aminoacyl-tRNA will ultimately migrate to the 3’ position via transesterification.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
tryptophanyl-tRNA aminoacylation label “tryptophanyl-tRNA aminoacylation”
tryptophanyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for protein translation

Added

tryptophanyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
tryptophanyl-tRNA aminoacylation term replaced by tRNA aminoacylation for protein translation
tryptophanyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2’-OH group of a tryptophan-accetping tRNA. The 2’-O-aminoacyl-tRNA will ultimately migrate to the 3’ position via transesterification.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
tryptophanyl-tRNA aminoacylation deprecated true
tryptophanyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004830 tryptophan-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0006418 tRNA aminoacylation for protein translation.”
tryptophanyl-tRNA aminoacylation label “obsolete tryptophanyl-tRNA aminoacylation”

type III site-specific deoxyribonuclease complex `http://purl.obolibrary.org/obo/GO_0019813`

Removed

type III site-specific deoxyribonuclease complex definition “A heterodimeric enzyme complex composed of two subunits, Res and Mod, that functions as an endonuclease and cleaves DNA. Cleavage will only occur when there are two un-methylated copies of a specific recognition site in an inverse orientation on the DNA. Cleavage occurs at a specific distance away from one of the recognition sites. The Mod subunit can act alone as a methyltansferase. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell.”
- database_cross_reference “PMID:12654995”

Added

type III site-specific deoxyribonuclease complex definition “A heterodimeric enzyme complex composed of two subunits, Res and Mod, that functions as an endonuclease and cleaves DNA. Cleavage will only occur when there are two un-methylated copies of a specific recognition site in an inverse orientation on the DNA. Cleavage occurs at a specific distance away from one of the recognition sites. The Mod subunit can act alone as a methyltransferase. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell.”
- database_cross_reference “PMID:12654995”

tyrosyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0006437`

Removed

tyrosyl-tRNA aminoacylation definition “The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2’-OH group of a tyrosine-accetping tRNA. The 2’-O-aminoacyl-tRNA will ultimately migrate to the 3’ position via transesterification.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
tyrosyl-tRNA aminoacylation label “tyrosyl-tRNA aminoacylation”
tyrosyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for protein translation

Added

tyrosyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
tyrosyl-tRNA aminoacylation term replaced by tRNA aminoacylation for protein translation
tyrosyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2’-OH group of a tyrosine-accetping tRNA. The 2’-O-aminoacyl-tRNA will ultimately migrate to the 3’ position via transesterification.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
tyrosyl-tRNA aminoacylation deprecated true
tyrosyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004831 tyrosine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0006418 tRNA aminoacylation for protein translation.”
tyrosyl-tRNA aminoacylation label “obsolete tyrosyl-tRNA aminoacylation”

ubiquitin-dependent glycoprotein ERAD pathway `http://purl.obolibrary.org/obo/GO_0097466`

Removed

ubiquitin-dependent glycoprotein ERAD pathway SubClassOf response to glycoprotein

undecaprenol kinase activity `http://purl.obolibrary.org/obo/GO_0009038`

Removed

undecaprenol kinase activity definition “Catalysis of the reaction: ATP + undecaprenol = ADP + undecaprenyl phosphate.”
- database_cross_reference “GOC:curators”

Added

undecaprenol kinase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32370”^^anyURI
undecaprenol kinase activity database_cross_reference “EC:2.7.1.66”
undecaprenol kinase activity database_cross_reference “KEGG_REACTION:R05626”
undecaprenol kinase activity database_cross_reference “MetaCyc:UNDECAPRENOL-KINASE-RXN”
undecaprenol kinase activity database_cross_reference “RHEA:23752”
undecaprenol kinase activity database_cross_reference “RHEA:28122”
undecaprenol kinase activity has_narrow_synonym “ditrans,polycis-undecaprenol kinase activity”
undecaprenol kinase activity has_related_synonym “all-trans undecaprenol kinase activity”
undecaprenol kinase activity has_related_synonym “di-trans, poly-cis-undecaprenol kinase activity”
undecaprenol kinase activity exactMatch 2.7.1.66
undecaprenol kinase activity narrowMatch UNDECAPRENOL-KINASE-RXN
undecaprenol kinase activity narrowMatch 23752
undecaprenol kinase activity narrowMatch 28122
undecaprenol kinase activity narrowMatch R05626
undecaprenol kinase activity definition “Catalysis of the reaction: ATP + undecaprenol = ADP + undecaprenyl phosphate.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:33310291”
undecaprenol kinase activity comment “Undecaprenol kinase has broad substrate specificity and is capable of phosphorylating all-trans-undecaprenol as well as di-trans,poly-cis-undecaprenol (PMID:33310291).”

undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity `http://purl.obolibrary.org/obo/GO_0050511`

Removed

undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity has_related_synonym “UDP-N-acetyl-D-glucosamine:N-acetyl-alpha-D-muramyl(oyl-L-Ala- gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol beta-1,4-N-acetylglucosaminlytransferase activity”
- database_cross_reference “EC:2.4.1.227”

Added

undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity has_related_synonym “UDP-N-acetyl-D-glucosamine:N-acetyl-alpha-D-muramyl(oyl-L-Ala- gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol beta-1,4-N-acetylglucosaminyltransferase activity”
- database_cross_reference “EC:2.4.1.227”

unfolded protein holdase activity `http://purl.obolibrary.org/obo/GO_0140309`

Removed

unfolded protein holdase activity definition “A protein carrier activity that binds to a protein in an unfolded state and escorts it to an acceptor molecule or to a specific location. The unfolded protein carrier prevents aggregation of the target protein while its being delivers to its final destination.”
- database_cross_reference “PMID:39488384”

Added

unfolded protein holdase activity has_narrow_synonym “carbohydrate-binding holdase”
unfolded protein holdase activity has_narrow_synonym “lectin chaperone”
unfolded protein holdase activity definition “A protein carrier activity that binds to a protein in an unfolded state and escorts it to an acceptor molecule or to a specific location. The unfolded protein carrier prevents aggregation of the target protein until it is delivered to its final destination.”
- database_cross_reference “PMID:39488384”

urate catabolic process `http://purl.obolibrary.org/obo/GO_0019628`

Removed

urate catabolic process SubClassOf small molecule catabolic process

valyl-tRNA aminoacylation `http://purl.obolibrary.org/obo/GO_0006438`

Removed

valyl-tRNA aminoacylation definition “The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2’-OH group of a valine-accetping tRNA. The 2’-O-aminoacyl-tRNA will ultimately migrate to the 3’ position via transesterification.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
valyl-tRNA aminoacylation label “valyl-tRNA aminoacylation”
valyl-tRNA aminoacylation SubClassOf tRNA aminoacylation for protein translation

Added

valyl-tRNA aminoacylation term tracker item “https://github.com/geneontology/go-ontology/issues/15375”^^anyURI
valyl-tRNA aminoacylation term replaced by tRNA aminoacylation for protein translation
valyl-tRNA aminoacylation definition “OBSOLETE. The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2’-OH group of a valine-accetping tRNA. The 2’-O-aminoacyl-tRNA will ultimately migrate to the 3’ position via transesterification.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”
valyl-tRNA aminoacylation deprecated true
valyl-tRNA aminoacylation comment “The reason for obsoletion is that this term restates an existing molecular function, GO:0004832 valine-tRNA ligase activity, and adds nothing beyond it. Gene products should be annotated to that molecular function; the biological process is covered by GO:0006418 tRNA aminoacylation for protein translation.”
valyl-tRNA aminoacylation label “obsolete valyl-tRNA aminoacylation”

venom-mediated activation of pH-gated ion channel activity `http://purl.obolibrary.org/obo/GO_0044734`

Removed

venom-mediated activation of pH-gated ion channel activity definition “A process in which an organism initiates, promotes, or enhances the activity of a pH-gated (also known as acid-sensing ion channel (ASIC)) in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:23034652”
- database_cross_reference “GOC:fj”
venom-mediated activation of pH-gated ion channel activity label “venom-mediated activation of pH-gated ion channel activity”
venom-mediated activation of pH-gated ion channel activity SubClassOf venom-mediated perturbation of pH-gated ion channel activity

Added

venom-mediated activation of pH-gated ion channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
venom-mediated activation of pH-gated ion channel activity consider channel activator activity
venom-mediated activation of pH-gated ion channel activity definition “OBSOLETE. A process in which an organism initiates, promotes, or enhances the activity of a pH-gated (also known as acid-sensing ion channel (ASIC)) in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:23034652”
- database_cross_reference “GOC:fj”
venom-mediated activation of pH-gated ion channel activity deprecated true
venom-mediated activation of pH-gated ion channel activity comment “This term was obsoleted because it represents a molecular function.”
venom-mediated activation of pH-gated ion channel activity label “obsolete venom-mediated activation of pH-gated ion channel activity”

venom-mediated activation of voltage-gated sodium channel activity `http://purl.obolibrary.org/obo/GO_0044494`

Removed

venom-mediated activation of voltage-gated sodium channel activity definition “A process in which an organism initiates, promotes, or enhances the activity of a voltage-gated sodium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:21781281”
venom-mediated activation of voltage-gated sodium channel activity label “venom-mediated activation of voltage-gated sodium channel activity”
venom-mediated activation of voltage-gated sodium channel activity SubClassOf venom-mediated perturbation of voltage-gated sodium channel activity

Added

venom-mediated activation of voltage-gated sodium channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
venom-mediated activation of voltage-gated sodium channel activity consider sodium channel activator activity
venom-mediated activation of voltage-gated sodium channel activity definition “OBSOLETE. A process in which an organism initiates, promotes, or enhances the activity of a voltage-gated sodium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:21781281”
venom-mediated activation of voltage-gated sodium channel activity deprecated true
venom-mediated activation of voltage-gated sodium channel activity comment “This term was obsoleted because it represents a molecular function.”
venom-mediated activation of voltage-gated sodium channel activity label “obsolete venom-mediated activation of voltage-gated sodium channel activity”

venom-mediated inhibition of calcium channel activity `http://purl.obolibrary.org/obo/GO_0044473`

Removed

venom-mediated inhibition of calcium channel activity definition “A process in which an organism inhibits or disrupts the activity of a calcium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:20920515”
venom-mediated inhibition of calcium channel activity label “venom-mediated inhibition of calcium channel activity”
venom-mediated inhibition of calcium channel activity SubClassOf venom-mediated perturbation of calcium channel activity

Added

venom-mediated inhibition of calcium channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
venom-mediated inhibition of calcium channel activity consider calcium channel inhibitor activity
venom-mediated inhibition of calcium channel activity definition “OBSOLETE. A process in which an organism inhibits or disrupts the activity of a calcium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:20920515”
venom-mediated inhibition of calcium channel activity deprecated true
venom-mediated inhibition of calcium channel activity comment “This term was obsoleted because it represents a molecular function.”
venom-mediated inhibition of calcium channel activity label “obsolete venom-mediated inhibition of calcium channel activity”

venom-mediated inhibition of high voltage-gated calcium channel activity `http://purl.obolibrary.org/obo/GO_0044475`

Removed

venom-mediated inhibition of high voltage-gated calcium channel activity definition “A process in which an organism inhibits or disrupts the activity of a high voltage-gated calcium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:20920515”
venom-mediated inhibition of high voltage-gated calcium channel activity label “venom-mediated inhibition of high voltage-gated calcium channel activity”
venom-mediated inhibition of high voltage-gated calcium channel activity SubClassOf venom-mediated inhibition of voltage-gated calcium channel activity

Added

venom-mediated inhibition of high voltage-gated calcium channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
venom-mediated inhibition of high voltage-gated calcium channel activity consider calcium channel inhibitor activity
venom-mediated inhibition of high voltage-gated calcium channel activity definition “OBSOLETE. A process in which an organism inhibits or disrupts the activity of a high voltage-gated calcium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:20920515”
venom-mediated inhibition of high voltage-gated calcium channel activity deprecated true
venom-mediated inhibition of high voltage-gated calcium channel activity comment “This term was obsoleted because it represents a molecular function.”
venom-mediated inhibition of high voltage-gated calcium channel activity label “obsolete venom-mediated inhibition of high voltage-gated calcium channel activity”

venom-mediated inhibition of low voltage-gated calcium channel activity `http://purl.obolibrary.org/obo/GO_0044476`

Removed

venom-mediated inhibition of low voltage-gated calcium channel activity definition “A process in which an organism inhibits or disrupts the activity of a low voltage-gated calcium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:20920515”
venom-mediated inhibition of low voltage-gated calcium channel activity label “venom-mediated inhibition of low voltage-gated calcium channel activity”
venom-mediated inhibition of low voltage-gated calcium channel activity SubClassOf venom-mediated inhibition of voltage-gated calcium channel activity

Added

venom-mediated inhibition of low voltage-gated calcium channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
venom-mediated inhibition of low voltage-gated calcium channel activity consider calcium channel inhibitor activity
venom-mediated inhibition of low voltage-gated calcium channel activity definition “OBSOLETE. A process in which an organism inhibits or disrupts the activity of a low voltage-gated calcium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:20920515”
venom-mediated inhibition of low voltage-gated calcium channel activity deprecated true
venom-mediated inhibition of low voltage-gated calcium channel activity comment “This term was obsoleted because it represents a molecular function.”
venom-mediated inhibition of low voltage-gated calcium channel activity label “obsolete venom-mediated inhibition of low voltage-gated calcium channel activity”

venom-mediated inhibition of pH-gated ion channel activity `http://purl.obolibrary.org/obo/GO_0044735`

Removed

venom-mediated inhibition of pH-gated ion channel activity definition “A process in which an organism inhibits or disrupts the activity of a pH-gated (also known as acid-sensing ion channel (ASIC)) in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:23034652”
- database_cross_reference “GOC:fj”
venom-mediated inhibition of pH-gated ion channel activity label “venom-mediated inhibition of pH-gated ion channel activity”
venom-mediated inhibition of pH-gated ion channel activity SubClassOf venom-mediated perturbation of pH-gated ion channel activity

Added

venom-mediated inhibition of pH-gated ion channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
venom-mediated inhibition of pH-gated ion channel activity consider ion channel inhibitor activity
venom-mediated inhibition of pH-gated ion channel activity definition “OBSOLETE. A process in which an organism inhibits or disrupts the activity of a pH-gated (also known as acid-sensing ion channel (ASIC)) in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:23034652”
- database_cross_reference “GOC:fj”
venom-mediated inhibition of pH-gated ion channel activity deprecated true
venom-mediated inhibition of pH-gated ion channel activity comment “This term was obsoleted because it represents a molecular function.”
venom-mediated inhibition of pH-gated ion channel activity label “obsolete venom-mediated inhibition of pH-gated ion channel activity”

venom-mediated inhibition of voltage-gated calcium channel activity `http://purl.obolibrary.org/obo/GO_0044474`

Removed

venom-mediated inhibition of voltage-gated calcium channel activity definition “A process in which an organism inhibits or disrupts the activity of a voltage-gated calcium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:20920515”
venom-mediated inhibition of voltage-gated calcium channel activity label “venom-mediated inhibition of voltage-gated calcium channel activity”
venom-mediated inhibition of voltage-gated calcium channel activity SubClassOf venom-mediated inhibition of calcium channel activity

Added

venom-mediated inhibition of voltage-gated calcium channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
venom-mediated inhibition of voltage-gated calcium channel activity consider calcium channel inhibitor activity
venom-mediated inhibition of voltage-gated calcium channel activity definition “OBSOLETE. A process in which an organism inhibits or disrupts the activity of a voltage-gated calcium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:20920515”
venom-mediated inhibition of voltage-gated calcium channel activity deprecated true
venom-mediated inhibition of voltage-gated calcium channel activity comment “This term was obsoleted because it represents a molecular function.”
venom-mediated inhibition of voltage-gated calcium channel activity label “obsolete venom-mediated inhibition of voltage-gated calcium channel activity”

venom-mediated inhibition of voltage-gated potassium channel activity `http://purl.obolibrary.org/obo/GO_0044562`

Removed

venom-mediated inhibition of voltage-gated potassium channel activity definition “A process in which an organism inhibits or disrupts the activity of a voltage-gated potassium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
venom-mediated inhibition of voltage-gated potassium channel activity label “venom-mediated inhibition of voltage-gated potassium channel activity”
venom-mediated inhibition of voltage-gated potassium channel activity SubClassOf venom-mediated perturbation of voltage-gated potassium channel activity

Added

venom-mediated inhibition of voltage-gated potassium channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
venom-mediated inhibition of voltage-gated potassium channel activity consider voltage-gated potassium channel inhibitor activity
venom-mediated inhibition of voltage-gated potassium channel activity definition “OBSOLETE. A process in which an organism inhibits or disrupts the activity of a voltage-gated potassium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
venom-mediated inhibition of voltage-gated potassium channel activity deprecated true
venom-mediated inhibition of voltage-gated potassium channel activity comment “This term was obsoleted because it represents a molecular function.”
venom-mediated inhibition of voltage-gated potassium channel activity label “obsolete venom-mediated inhibition of voltage-gated potassium channel activity”

venom-mediated inhibition of voltage-gated sodium channel activity `http://purl.obolibrary.org/obo/GO_0044493`

Removed

venom-mediated inhibition of voltage-gated sodium channel activity definition “A process in which an organism inhibits or disrupts the activity of a voltage-gated sodium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:21781281”
venom-mediated inhibition of voltage-gated sodium channel activity label “venom-mediated inhibition of voltage-gated sodium channel activity”
venom-mediated inhibition of voltage-gated sodium channel activity SubClassOf venom-mediated perturbation of voltage-gated sodium channel activity

Added

venom-mediated inhibition of voltage-gated sodium channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
venom-mediated inhibition of voltage-gated sodium channel activity consider sodium channel inhibitor activity
venom-mediated inhibition of voltage-gated sodium channel activity definition “OBSOLETE. A process in which an organism inhibits or disrupts the activity of a voltage-gated sodium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:21781281”
venom-mediated inhibition of voltage-gated sodium channel activity deprecated true
venom-mediated inhibition of voltage-gated sodium channel activity comment “This term was obsoleted because it represents a molecular function.”
venom-mediated inhibition of voltage-gated sodium channel activity label “obsolete venom-mediated inhibition of voltage-gated sodium channel activity”

venom-mediated perturbation of calcium channel activity `http://purl.obolibrary.org/obo/GO_0044472`

Removed

venom-mediated perturbation of calcium channel activity definition “A process in which an organism alters or subverts the activity of a calcium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:20920515”
venom-mediated perturbation of calcium channel activity label “venom-mediated perturbation of calcium channel activity”
venom-mediated perturbation of calcium channel activity SubClassOf venom-mediated perturbation of ion channel activity

Added

venom-mediated perturbation of calcium channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
venom-mediated perturbation of calcium channel activity consider calcium channel regulator activity
venom-mediated perturbation of calcium channel activity definition “OBSOLETE. A process in which an organism alters or subverts the activity of a calcium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:20920515”
venom-mediated perturbation of calcium channel activity deprecated true
venom-mediated perturbation of calcium channel activity comment “This term was obsoleted because it represents a molecular function.”
venom-mediated perturbation of calcium channel activity label “obsolete venom-mediated perturbation of calcium channel activity”

venom-mediated perturbation of ion channel activity `http://purl.obolibrary.org/obo/GO_0044560`

Removed

venom-mediated perturbation of ion channel activity definition “A process in which an organism alters or subverts the activity of an ion channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
venom-mediated perturbation of ion channel activity label “venom-mediated perturbation of ion channel activity”
venom-mediated perturbation of ion channel activity SubClassOf venom-mediated perturbation of biological process

Added

venom-mediated perturbation of ion channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
venom-mediated perturbation of ion channel activity definition “OBSOLETE. A process in which an organism alters or subverts the activity of an ion channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
venom-mediated perturbation of ion channel activity deprecated true
venom-mediated perturbation of ion channel activity comment “This term was obsoleted because it represents a molecular function.”
venom-mediated perturbation of ion channel activity label “obsolete venom-mediated perturbation of ion channel activity”

venom-mediated perturbation of pH-gated ion channel activity `http://purl.obolibrary.org/obo/GO_0044733`

Removed

venom-mediated perturbation of pH-gated ion channel activity definition “A process in which an organism alters or subverts the activity of a pH-gated (also known as acid-sensing ion channel (ASIC)) in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:23034652”
- database_cross_reference “GOC:fj”
venom-mediated perturbation of pH-gated ion channel activity label “venom-mediated perturbation of pH-gated ion channel activity”
venom-mediated perturbation of pH-gated ion channel activity SubClassOf venom-mediated perturbation of ion channel activity

Added

venom-mediated perturbation of pH-gated ion channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
venom-mediated perturbation of pH-gated ion channel activity consider ion channel regulator activity
venom-mediated perturbation of pH-gated ion channel activity definition “OBSOLETE. A process in which an organism alters or subverts the activity of a pH-gated (also known as acid-sensing ion channel (ASIC)) in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:23034652”
- database_cross_reference “GOC:fj”
venom-mediated perturbation of pH-gated ion channel activity deprecated true
venom-mediated perturbation of pH-gated ion channel activity comment “This term was obsoleted because it represents a molecular function.”
venom-mediated perturbation of pH-gated ion channel activity label “obsolete venom-mediated perturbation of pH-gated ion channel activity”

venom-mediated perturbation of voltage-gated potassium channel activity `http://purl.obolibrary.org/obo/GO_0044559`

Removed

venom-mediated perturbation of voltage-gated potassium channel activity definition “A process in which an organism alters or subverts the activity of a voltage-gated potassium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
venom-mediated perturbation of voltage-gated potassium channel activity label “venom-mediated perturbation of voltage-gated potassium channel activity”
venom-mediated perturbation of voltage-gated potassium channel activity SubClassOf venom-mediated perturbation of ion channel activity

Added

venom-mediated perturbation of voltage-gated potassium channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
venom-mediated perturbation of voltage-gated potassium channel activity consider potassium channel regulator activity
venom-mediated perturbation of voltage-gated potassium channel activity definition “OBSOLETE. A process in which an organism alters or subverts the activity of a voltage-gated potassium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
venom-mediated perturbation of voltage-gated potassium channel activity deprecated true
venom-mediated perturbation of voltage-gated potassium channel activity comment “This term was obsoleted because it represents a molecular function.”
venom-mediated perturbation of voltage-gated potassium channel activity label “obsolete venom-mediated perturbation of voltage-gated potassium channel activity”

venom-mediated perturbation of voltage-gated sodium channel activity `http://purl.obolibrary.org/obo/GO_0044492`

Removed

venom-mediated perturbation of voltage-gated sodium channel activity definition “A process in which an organism alters or subverts the activity of a voltage-gated sodium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:21781281”
venom-mediated perturbation of voltage-gated sodium channel activity label “venom-mediated perturbation of voltage-gated sodium channel activity”
venom-mediated perturbation of voltage-gated sodium channel activity SubClassOf venom-mediated perturbation of ion channel activity

Added

venom-mediated perturbation of voltage-gated sodium channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
venom-mediated perturbation of voltage-gated sodium channel activity consider sodium channel regulator activity
venom-mediated perturbation of voltage-gated sodium channel activity definition “OBSOLETE. A process in which an organism alters or subverts the activity of a voltage-gated sodium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:21781281”
venom-mediated perturbation of voltage-gated sodium channel activity deprecated true
venom-mediated perturbation of voltage-gated sodium channel activity comment “This term was obsoleted because it represents a molecular function.”
venom-mediated perturbation of voltage-gated sodium channel activity label “obsolete venom-mediated perturbation of voltage-gated sodium channel activity”

venom-mediated vasoconstriction `http://purl.obolibrary.org/obo/GO_0044499`

Removed

venom-mediated vasoconstriction definition “A process in which an organism initiates, promotes, or enhances the narrowing (constriction) of blood vessels by small muscles in their walls in another organism via the action of a venom, concomittantly increasing blood pressure in the bitten/stung organism.”
- database_cross_reference “PMID:19837656”
- database_cross_reference “GOC:fj”

Added

venom-mediated vasoconstriction definition “A process in which an organism initiates, promotes, or enhances the narrowing (constriction) of blood vessels by small muscles in their walls in another organism via the action of a venom, concomitantly increasing blood pressure in the bitten/stung organism.”
- database_cross_reference “PMID:19837656”
- database_cross_reference “GOC:fj”

venom-mediated vasoconstriction via activation of endothelin receptor signaling pathway `http://purl.obolibrary.org/obo/GO_0140183`

Removed

venom-mediated vasoconstriction via activation of endothelin receptor signaling pathway definition “A process in which an organism promotes the narrowing (constriction) of blood vessels, by inhibiting the widening (dilation) of blood vessels in another organism via the action of a venom that activates endothelin receptor signaling pathway, concomittantly increasing blood pressure in the bitten/stung organism.”
- database_cross_reference “PMID:16277978”

Added

venom-mediated vasoconstriction via activation of endothelin receptor signaling pathway definition “A process in which an organism promotes the narrowing (constriction) of blood vessels, by inhibiting the widening (dilation) of blood vessels in another organism via the action of a venom that activates endothelin receptor signaling pathway, concomitantly increasing blood pressure in the bitten/stung organism.”
- database_cross_reference “PMID:16277978”

venom-mediated vasodilation `http://purl.obolibrary.org/obo/GO_0044551`

Removed

venom-mediated vasodilation definition “A process in which an organism initiates, promotes, or enhances the widening of blood vessels by small muscles in their walls in another organism via the action of a venom, concomittantly reducing blood pressure in the bitten/stung organism.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:21050868”
- database_cross_reference “GOC:ecd”

Added

venom-mediated vasodilation definition “A process in which an organism initiates, promotes, or enhances the widening of blood vessels by small muscles in their walls in another organism via the action of a venom, concomitantly reducing blood pressure in the bitten/stung organism.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:21050868”
- database_cross_reference “GOC:ecd”

venom-mediated vasodilation by activation of bradykinin receptor signaling pathway `http://purl.obolibrary.org/obo/GO_0140162`

Removed

venom-mediated vasodilation by activation of bradykinin receptor signaling pathway definition “A process in which an organism initiates, promotes, or enhances vasodilation via the action of a venom that activates bradykinin-dependent signaling, concomittantly reducing blood pressure in the bitten/stung organism. This can take place via several mechanisms that affect endogenous bradykinin: either increasing its release by kallikrein-like proteases, increasing bradykinin action by potentiation, or inhibiting bradykinin degradation.”
- database_cross_reference “PMID:31370142”

Added

venom-mediated vasodilation by activation of bradykinin receptor signaling pathway definition “A process in which an organism initiates, promotes, or enhances vasodilation via the action of a venom that activates bradykinin-dependent signaling, concomitantly reducing blood pressure in the bitten/stung organism. This can take place via several mechanisms that affect endogenous bradykinin: either increasing its release by kallikrein-like proteases, increasing bradykinin action by potentiation, or inhibiting bradykinin degradation.”
- database_cross_reference “PMID:31370142”

venom-mediated vasodilation by activation of nitric oxide-cGMP-mediated signaling `http://purl.obolibrary.org/obo/GO_0140165`

Removed

venom-mediated vasodilation by activation of nitric oxide-cGMP-mediated signaling definition “A process in which an organism initiates, promotes, or enhances vasodilation via the action of a venom that activates nitric oxide-cGMP-mediated signaling, concomittantly reducing blood pressure in the bitten/stung organism.”
- database_cross_reference “PMID:10512636”

Added

venom-mediated vasodilation by activation of nitric oxide-cGMP-mediated signaling definition “A process in which an organism initiates, promotes, or enhances vasodilation via the action of a venom that activates nitric oxide-cGMP-mediated signaling, concomitantly reducing blood pressure in the bitten/stung organism.”
- database_cross_reference “PMID:10512636”

venom-mediated vasodilation via suppression of angiotensin maturation `http://purl.obolibrary.org/obo/GO_0140166`

Removed

venom-mediated vasodilation via suppression of angiotensin maturation definition “A process in which an organism initiates, promotes, or enhances vasodilation via the action of a venom that prevents angiotensin maturation, concomittantly reducing blood pressure in the bitten/stung organism.”
- database_cross_reference “PMID:31370142”

Added

venom-mediated vasodilation via suppression of angiotensin maturation definition “A process in which an organism initiates, promotes, or enhances vasodilation via the action of a venom that prevents angiotensin maturation, concomitantly reducing blood pressure in the bitten/stung organism.”
- database_cross_reference “PMID:31370142”

very long-chain fatty acid beta-oxidation `http://purl.obolibrary.org/obo/GO_0140493`

Removed

very long-chain fatty acid beta-oxidation definition “A fatty acid beta-oxidation pathway acting on a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons. The partway stars with the conversion of an acyl-CoA to a trans-2-enoyl-CoA, catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).”
- database_cross_reference “PMID:32169171”
- database_cross_reference “PMID:17028011”
- database_cross_reference “GOC:ha”
very long-chain fatty acid beta-oxidation comment “While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).”
very long-chain fatty acid beta-oxidation label “very long-chain fatty acid beta-oxidation”
very long-chain fatty acid beta-oxidation SubClassOf very long-chain fatty acid catabolic process

Added

very long-chain fatty acid beta-oxidation term tracker item “https://github.com/geneontology/go-ontology/issues/32227”^^anyURI
very long-chain fatty acid beta-oxidation term replaced by very long-chain fatty acid catabolic process
very long-chain fatty acid beta-oxidation definition “OBSOLETE. A fatty acid beta-oxidation pathway acting on a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons. The partway stars with the conversion of an acyl-CoA to a trans-2-enoyl-CoA, catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).”
- database_cross_reference “PMID:32169171”
- database_cross_reference “PMID:17028011”
- database_cross_reference “GOC:ha”
very long-chain fatty acid beta-oxidation deprecated true
very long-chain fatty acid beta-oxidation comment “This term was obsoleted because it represents the same process as very long-chain fatty acid catabolic process ; GO:0042760.”
very long-chain fatty acid beta-oxidation label “obsolete very long-chain fatty acid beta-oxidation”

very long-chain fatty-acyl-CoA catabolic process `http://purl.obolibrary.org/obo/GO_0036113`

Removed

very long-chain fatty-acyl-CoA catabolic process comment “While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).”

voltage-driven motor activity `http://purl.obolibrary.org/obo/GO_0170085`

Added

Class: voltage-driven motor activity
voltage-driven motor activity term tracker item “https://github.com/geneontology/go-ontology/issues/32556”^^anyURI
voltage-driven motor activity created by “ew”
voltage-driven motor activity creation date “2026-09-02T21:59:45Z”
voltage-driven motor activity has_exact_synonym “electromechanical transducer activity”
voltage-driven motor activity has_exact_synonym “voltage-sensitive motor activity”
voltage-driven motor activity has_obo_namespace “molecular_function”
voltage-driven motor activity has_related_synonym “electromotility activity”
voltage-driven motor activity id “GO:0170085”
voltage-driven motor activity definition “A motor activity that detects and converts a change in transmembrane electrical potential directly into mechanical force or a conformational change, without coupling to ATP hydrolysis, ion transport, or a proton-motive force. As an example, mammalian prestin converts voltage changes into outer hair cell movement which is required for sound amplification in the hearing organ.”
- database_cross_reference “PMID:12239568”
voltage-driven motor activity label “voltage-driven motor activity”
voltage-driven motor activity SubClassOf energy transducer activity

voltage-gated potassium channel inhibitor activity `http://purl.obolibrary.org/obo/GO_7770090`

Added

Class: voltage-gated potassium channel inhibitor activity
voltage-gated potassium channel inhibitor activity term tracker item “https://github.com/geneontology/go-ontology/issues/32371”^^anyURI
voltage-gated potassium channel inhibitor activity created by “ai4c-agent”
voltage-gated potassium channel inhibitor activity creation date “2026-07-28T16:49:43Z”
voltage-gated potassium channel inhibitor activity has_exact_synonym “Kv channel inhibitor activity”
voltage-gated potassium channel inhibitor activity has_exact_synonym “Kv inhibitor activity”
voltage-gated potassium channel inhibitor activity has_exact_synonym “voltage-gated potassium channel (Kv) inhibitor activity”
voltage-gated potassium channel inhibitor activity has_obo_namespace “molecular_function”
voltage-gated potassium channel inhibitor activity id “GO:7770090”
voltage-gated potassium channel inhibitor activity definition “Binds to and stops, prevents, or reduces the activity of a voltage-gated potassium channel.”
- database_cross_reference “PMID:35797055”
voltage-gated potassium channel inhibitor activity label “voltage-gated potassium channel inhibitor activity”
voltage-gated potassium channel inhibitor activity SubClassOf potassium channel inhibitor activity
voltage-gated potassium channel inhibitor activity SubClassOf negatively regulates some voltage-gated potassium channel activity

zygotic determination of anterior/posterior axis, embryo `http://purl.obolibrary.org/obo/GO_0007354`

Removed

zygotic determination of anterior/posterior axis, embryo definition “The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

zygotic determination of anterior/posterior axis, embryo term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
zygotic determination of anterior/posterior axis, embryo definition “The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade.”
- database_cross_reference “ISBN:0879694238”

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go-ontology

Ontology comparison

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Ontology imports

Ontology annotations

Removed

Added

‘de novo’ NAD+ biosynthetic process from L-tryptophan http://purl.obolibrary.org/obo/GO_0034354

Added

(2R)-2-hydroxycarboxylate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0140174

Removed

Added

(R)-mandelate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0097620

Removed

Added

1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity http://purl.obolibrary.org/obo/GO_0062181

Removed

Added

10-formyltetrahydrofolate biosynthetic process http://purl.obolibrary.org/obo/GO_0009257

Removed

Added

2-(3-amino-3-carboxypropyl)histidine synthase complex http://purl.obolibrary.org/obo/GO_0120513

Removed

Added

2-oxoadipate decarboxylation to glutaryl-CoA http://purl.obolibrary.org/obo/GO_0120578

Added

2-oxoadipate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0160166

Added

4’-phosphopantetheine phosphatase activity http://purl.obolibrary.org/obo/GO_7770095

Added

4-chlorobenzoate dehalogenase activity http://purl.obolibrary.org/obo/GO_0047576

Removed

Added

6-phosphofructokinase activity http://purl.obolibrary.org/obo/GO_0003872

Removed

Added

7-methylguanosine cap hypermethylation http://purl.obolibrary.org/obo/GO_0036261

Removed

Added

ABC-type cadmium transporter activity http://purl.obolibrary.org/obo/GO_0015434

Added

ABC-type protein transporter activity http://purl.obolibrary.org/obo/GO_0015462

Removed

Added

ATG2-ATG18 complex http://purl.obolibrary.org/obo/GO_0062079

Removed

Added

ATP-dependent folded protein transmembrane transporter activity http://purl.obolibrary.org/obo/GO_7770098

Added

ATP-dependent protein-RNA complex displacement activity http://purl.obolibrary.org/obo/GO_7770106

Added

ATPase-coupled L-glutamate tranmembrane transporter activity http://purl.obolibrary.org/obo/GO_0102013

Removed

Added

Atg9-containing vesicle http://purl.obolibrary.org/obo/GO_7770115

Added

B cell tolerance induction in mucosal-associated lymphoid tissue http://purl.obolibrary.org/obo/GO_0002402

Removed

Added

B-type glycerophospholipase activity http://purl.obolibrary.org/obo/GO_0102545

Removed

Added

D-glucosamine biosynthetic process http://purl.obolibrary.org/obo/GO_0006042

Removed

D-glucosamine catabolic process http://purl.obolibrary.org/obo/GO_0006043

Removed

D-glucosamine metabolic process http://purl.obolibrary.org/obo/GO_0006041

Removed

Added

D-lactate dehydrogenase (FAD) activity http://purl.obolibrary.org/obo/GO_0140170

Added

D-sorbitol biosynthetic process http://purl.obolibrary.org/obo/GO_0006061

Added

D-xylose reductase (NADPH) activity http://purl.obolibrary.org/obo/GO_0032866

Added

DNA ADP-ribosylation http://purl.obolibrary.org/obo/GO_0030592

Removed

Added

DNA recombinase auxiliary factor complex http://purl.obolibrary.org/obo/GO_0120231

‘de novo’ NAD+ biosynthetic process from L-tryptophan `http://purl.obolibrary.org/obo/GO_0034354`

(2R)-2-hydroxycarboxylate dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0140174`

(R)-mandelate dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0097620`

1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0062181`

10-formyltetrahydrofolate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009257`

2-(3-amino-3-carboxypropyl)histidine synthase complex `http://purl.obolibrary.org/obo/GO_0120513`

2-oxoadipate decarboxylation to glutaryl-CoA `http://purl.obolibrary.org/obo/GO_0120578`

2-oxoadipate dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0160166`

4’-phosphopantetheine phosphatase activity `http://purl.obolibrary.org/obo/GO_7770095`

4-chlorobenzoate dehalogenase activity `http://purl.obolibrary.org/obo/GO_0047576`

6-phosphofructokinase activity `http://purl.obolibrary.org/obo/GO_0003872`

7-methylguanosine cap hypermethylation `http://purl.obolibrary.org/obo/GO_0036261`

ABC-type cadmium transporter activity `http://purl.obolibrary.org/obo/GO_0015434`

ABC-type protein transporter activity `http://purl.obolibrary.org/obo/GO_0015462`

ATG2-ATG18 complex `http://purl.obolibrary.org/obo/GO_0062079`

ATP-dependent folded protein transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_7770098`

ATP-dependent protein-RNA complex displacement activity `http://purl.obolibrary.org/obo/GO_7770106`

ATPase-coupled L-glutamate tranmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0102013`

Atg9-containing vesicle `http://purl.obolibrary.org/obo/GO_7770115`

B cell tolerance induction in mucosal-associated lymphoid tissue `http://purl.obolibrary.org/obo/GO_0002402`

B-type glycerophospholipase activity `http://purl.obolibrary.org/obo/GO_0102545`

D-glucosamine biosynthetic process `http://purl.obolibrary.org/obo/GO_0006042`

D-glucosamine catabolic process `http://purl.obolibrary.org/obo/GO_0006043`

D-glucosamine metabolic process `http://purl.obolibrary.org/obo/GO_0006041`

D-lactate dehydrogenase (FAD) activity `http://purl.obolibrary.org/obo/GO_0140170`

D-sorbitol biosynthetic process `http://purl.obolibrary.org/obo/GO_0006061`

D-xylose reductase (NADPH) activity `http://purl.obolibrary.org/obo/GO_0032866`

DNA ADP-ribosylation `http://purl.obolibrary.org/obo/GO_0030592`

DNA recombinase auxiliary factor complex `http://purl.obolibrary.org/obo/GO_0120231`

ER lumen protein retrieval receptor activity `http://purl.obolibrary.org/obo/GO_0046923`

ER membrane protein retrieval receptor activity `http://purl.obolibrary.org/obo/GO_7770094`

ER overload response `http://purl.obolibrary.org/obo/GO_0006983`

ERAD pathway `http://purl.obolibrary.org/obo/GO_0036503`

ESCRT III complex `http://purl.obolibrary.org/obo/GO_0000815`

FAD regeneration via ETF:ETFQO system `http://purl.obolibrary.org/obo/GO_7770096`

FMN adenylyltransferase activity `http://purl.obolibrary.org/obo/GO_0003919`

G-protein beta/gamma-subunit complex `http://purl.obolibrary.org/obo/GO_0031680`

GPI anchor remodelling `http://purl.obolibrary.org/obo/GO_0120574`

Hrd1p ubiquitin ligase complex `http://purl.obolibrary.org/obo/GO_0000836`

L-arabinose reductase (NADPH) activity `http://purl.obolibrary.org/obo/GO_0032867`

L-malate dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0030060`

L-methionine cycle `http://purl.obolibrary.org/obo/GO_0033353`

L-phenylalaine oxidase activity `http://purl.obolibrary.org/obo/GO_0106329`

N-acetylglucosamine biosynthetic process `http://purl.obolibrary.org/obo/GO_0006045`

N-acetylglucosamine catabolic process `http://purl.obolibrary.org/obo/GO_0006046`

N-acetylglucosamine metabolic process `http://purl.obolibrary.org/obo/GO_0006044`

N-acetylmannosamine biosynthetic process `http://purl.obolibrary.org/obo/GO_0006052`

N-acetylmannosamine catabolic process `http://purl.obolibrary.org/obo/GO_0006053`

N-acetylmannosamine metabolic process `http://purl.obolibrary.org/obo/GO_0006051`

N-acetylneuraminate biosynthetic process `http://purl.obolibrary.org/obo/GO_0046380`

N-acetylneuraminate catabolic process `http://purl.obolibrary.org/obo/GO_0019262`

N-acetylneuraminate metabolic process `http://purl.obolibrary.org/obo/GO_0006054`

NAD+ nucleosidase activity, cyclic ADP-ribose generating `http://purl.obolibrary.org/obo/GO_0061809`

NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity `http://purl.obolibrary.org/obo/GO_0030701`

NAD+-protein-arginine ADP-ribosyltransferase activity `http://purl.obolibrary.org/obo/GO_0106274`

NAD-cap decapping `http://purl.obolibrary.org/obo/GO_0110155`