go-ontology

Ontology comparison

Left

Ontology IRI: http://purl.obolibrary.org/obo/go.owl
Version IRI: http://purl.obolibrary.org/obo/go/releases/2026-01-23/go.owl
Loaded from: file:/__w/go-ontology/go-ontology/src/ontology/go-lastrelease.owl

Right

Ontology IRI: http://purl.obolibrary.org/obo/go.owl
Version IRI: http://purl.obolibrary.org/obo/go/releases/2026-03-29/go.owl
Loaded from: file:/__w/go-ontology/go-ontology/src/ontology/go.ofn

Ontology imports

Ontology annotations

Removed

versionInfo “2026-01-23”

Added

versionInfo “2026-03-29”

‘de novo’ L-methionine biosynthetic process `http://purl.obolibrary.org/obo/GO_0071266`

Removed

‘de novo’ L-methionine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid, from simpler components.”
- database_cross_reference “GOC:ecd”

Added

‘de novo’ L-methionine biosynthetic process narrowMatch PWY-5345
‘de novo’ L-methionine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
‘de novo’ L-methionine biosynthetic process database_cross_reference “MetaCyc:PWY-702”
‘de novo’ L-methionine biosynthetic process narrowMatch HSERMETANA-PWY
‘de novo’ L-methionine biosynthetic process narrowMatch PWY-7977
‘de novo’ L-methionine biosynthetic process database_cross_reference “MetaCyc:PWY-5347”
‘de novo’ L-methionine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid, from simpler components such as L-aspartate or L-homoserine. This process occurs in plants, bacteria, archae and fungi.”
- database_cross_reference “PMID:24939187”
- database_cross_reference “PMID:12818659”
‘de novo’ L-methionine biosynthetic process database_cross_reference “MetaCyc:HOMOSER-METSYN-PWY”
‘de novo’ L-methionine biosynthetic process database_cross_reference “MetaCyc:PWY-5345”
‘de novo’ L-methionine biosynthetic process narrowMatch PWY-5347
‘de novo’ L-methionine biosynthetic process database_cross_reference “MetaCyc:HSERMETANA-PWY”
‘de novo’ L-methionine biosynthetic process database_cross_reference “MetaCyc:PWY-7977”
‘de novo’ L-methionine biosynthetic process narrowMatch PWY-702
‘de novo’ L-methionine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31318”^^anyURI
‘de novo’ L-methionine biosynthetic process narrowMatch HOMOSER-METSYN-PWY

‘de novo’ pyridoxal 5’-phosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0036001`

Added

‘de novo’ pyridoxal 5’-phosphate biosynthetic process database_cross_reference “MetaCyc:PWY-6466”
‘de novo’ pyridoxal 5’-phosphate biosynthetic process narrowMatch PYRIDOXSYN-PWY
‘de novo’ pyridoxal 5’-phosphate biosynthetic process narrowMatch PWY-6466
‘de novo’ pyridoxal 5’-phosphate biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI

‘de novo’ pyrimidine nucleobase biosynthetic process `http://purl.obolibrary.org/obo/GO_0006207`

Removed

‘de novo’ pyrimidine nucleobase biosynthetic process has_exact_synonym “‘de novo’ pyrimidine base biosynthetic process”
- database_cross_reference “GOC:go_curators”

Added

‘de novo’ pyrimidine nucleobase biosynthetic process has_exact_synonym “‘de novo’ pyrimidine base biosynthetic process”
- database_cross_reference “GOC:curators”

(2E)-butenoyl-CoA hydratase activity `http://purl.obolibrary.org/obo/GO_0120092`

Added

(2E)-butenoyl-CoA hydratase activity narrowMatch 26558
(2E)-butenoyl-CoA hydratase activity database_cross_reference “RHEA:26558”
(2E)-butenoyl-CoA hydratase activity database_cross_reference “RHEA:17849”
(2E)-butenoyl-CoA hydratase activity narrowMatch 17849

(2E)-enoyl-CoA hydratase activity `http://purl.obolibrary.org/obo/GO_0080023`

Added

(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:39615”
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:39487”
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:39399”
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:39303”
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:39559”
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:39579”
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:78867”
(2E)-enoyl-CoA hydratase activity narrowMatch 39399
(2E)-enoyl-CoA hydratase activity narrowMatch 67216
(2E)-enoyl-CoA hydratase activity narrowMatch 78931
(2E)-enoyl-CoA hydratase activity narrowMatch 39591
(2E)-enoyl-CoA hydratase activity narrowMatch 39411
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:39439”
(2E)-enoyl-CoA hydratase activity narrowMatch 39423
(2E)-enoyl-CoA hydratase activity narrowMatch 39523
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:39499”
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:39387”
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:78931”
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:39687”
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:39343”
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:39523”
(2E)-enoyl-CoA hydratase activity narrowMatch 39343
(2E)-enoyl-CoA hydratase activity narrowMatch 39499
(2E)-enoyl-CoA hydratase activity narrowMatch 39375
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:39511”
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:39603”
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:72575”
(2E)-enoyl-CoA hydratase activity narrowMatch 39547
(2E)-enoyl-CoA hydratase activity narrowMatch 39603
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:39627”
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:39363”
(2E)-enoyl-CoA hydratase activity narrowMatch 39439
(2E)-enoyl-CoA hydratase activity narrowMatch 39579
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:39411”
(2E)-enoyl-CoA hydratase activity narrowMatch 72575
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:39351”
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:67228”
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:39699”
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:39475”
(2E)-enoyl-CoA hydratase activity narrowMatch 39639
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:39423”
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:39591”
(2E)-enoyl-CoA hydratase activity narrowMatch 39363
(2E)-enoyl-CoA hydratase activity narrowMatch 78863
(2E)-enoyl-CoA hydratase activity narrowMatch 39387
(2E)-enoyl-CoA hydratase activity narrowMatch 67228
(2E)-enoyl-CoA hydratase activity narrowMatch 39351
(2E)-enoyl-CoA hydratase activity narrowMatch 78867
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:78863”
(2E)-enoyl-CoA hydratase activity narrowMatch 39535
(2E)-enoyl-CoA hydratase activity narrowMatch 39303
(2E)-enoyl-CoA hydratase activity narrowMatch 46720
(2E)-enoyl-CoA hydratase activity narrowMatch 39627
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:46720”
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:39375”
(2E)-enoyl-CoA hydratase activity narrowMatch 39615
(2E)-enoyl-CoA hydratase activity narrowMatch 39511
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:67216”
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:39639”
(2E)-enoyl-CoA hydratase activity narrowMatch 39699
(2E)-enoyl-CoA hydratase activity narrowMatch 39687
(2E)-enoyl-CoA hydratase activity narrowMatch 39559
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:39547”
(2E)-enoyl-CoA hydratase activity narrowMatch 39475
(2E)-enoyl-CoA hydratase activity database_cross_reference “RHEA:39535”
(2E)-enoyl-CoA hydratase activity narrowMatch 39487

(2R)-2-hydroxyacid dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0140175`

Added

(2R)-2-hydroxyacid dehydrogenase (NADP+) activity `http://purl.obolibrary.org/obo/GO_0050578`

Added

(2R)-2-hydroxycarboxylate dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0140174`

Added

(2S)-2-aminobutanoate:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0120554`

Removed

(2S)-2-aminobutanoate:2-oxoglutarate transaminase activity label “2-aminobutanoate transaminase activity”

Added

(2S)-2-aminobutanoate:2-oxoglutarate transaminase activity has_exact_synonym “2-aminobutanoate transaminase activity”
(2S)-2-aminobutanoate:2-oxoglutarate transaminase activity label “(2S)-2-aminobutanoate:2-oxoglutarate transaminase activity”
(2S)-2-aminobutanoate:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI

(3R)-2’-hydroxyisoflavanone reductase (NADP+) activity `http://purl.obolibrary.org/obo/GO_0140860`

Added

(3R)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0106386`

Added

(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity `http://purl.obolibrary.org/obo/GO_0019171`

Added

(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0003857`

Added

(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity database_cross_reference “RHEA:40211”
(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity narrowMatch 78919
(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity database_cross_reference “RHEA:78919”
(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity narrowMatch 40211
(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity narrowMatch 78923
(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity narrowMatch 34851
(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity database_cross_reference “RHEA:78923”
(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity database_cross_reference “RHEA:34851”

(4S)-4-hydroxy-L-glutamate:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0047578`

Removed

(4S)-4-hydroxy-L-glutamate:2-oxoglutarate transaminase activity exactMatch 10480
(4S)-4-hydroxy-L-glutamate:2-oxoglutarate transaminase activity label “4-hydroxyglutamate transaminase activity”
(4S)-4-hydroxy-L-glutamate:2-oxoglutarate transaminase activity database_cross_reference “RHEA:10480”
(4S)-4-hydroxy-L-glutamate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 4-hydroxy-L-glutamate + 2-oxoglutarate = 4-hydroxy-2-oxoglutarate + L-glutamate.”
- database_cross_reference “EC:2.6.1.23”
- database_cross_reference “MetaCyc:4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN”

Added

(4S)-4-hydroxy-L-glutamate:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
(4S)-4-hydroxy-L-glutamate:2-oxoglutarate transaminase activity exactMatch 31235
(4S)-4-hydroxy-L-glutamate:2-oxoglutarate transaminase activity has_exact_synonym “4-hydroxyglutamate transaminase activity”
(4S)-4-hydroxy-L-glutamate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: (4S)-4-hydroxy-L-glutamate + 2-oxoglutarate = (4R)-4-hydroxy-2-oxoglutarate + L-glutamate.”
- database_cross_reference “RHEA:31235”
(4S)-4-hydroxy-L-glutamate:2-oxoglutarate transaminase activity database_cross_reference “RHEA:31235”
(4S)-4-hydroxy-L-glutamate:2-oxoglutarate transaminase activity label “(4S)-4-hydroxy-L-glutamate:2-oxoglutarate transaminase activity”

(R)-2-hydroxyglutarate dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0051990`

Added

(R)-2-hydroxyglutarate dehydrogenase activity database_cross_reference “RHEA:57168”
(R)-2-hydroxyglutarate dehydrogenase activity database_cross_reference “RHEA:51612”
(R)-2-hydroxyglutarate dehydrogenase activity narrowMatch 51192
(R)-2-hydroxyglutarate dehydrogenase activity narrowMatch 51612
(R)-2-hydroxyglutarate dehydrogenase activity database_cross_reference “RHEA:51192”
(R)-2-hydroxyglutarate dehydrogenase activity narrowMatch 57168

(R)-3-amino-2-methylpropionate:pyruvate transaminase activity `http://purl.obolibrary.org/obo/GO_0047305`

Removed

(R)-3-amino-2-methylpropionate:pyruvate transaminase activity label “(R)-3-amino-2-methylpropionate-pyruvate transaminase activity”
(R)-3-amino-2-methylpropionate:pyruvate transaminase activity comment “Note that this function was EC:2.6.1.61.”
(R)-3-amino-2-methylpropionate:pyruvate transaminase activity definition “Catalysis of the reaction: (2R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine.”
- database_cross_reference “EC:2.6.1.40”
- database_cross_reference “RHEA:18393”

Added

(R)-3-amino-2-methylpropionate:pyruvate transaminase activity has_exact_synonym “(R)-3-amino-2-methylpropionate-pyruvate transaminase activity”
(R)-3-amino-2-methylpropionate:pyruvate transaminase activity label “(R)-3-amino-2-methylpropionate:pyruvate transaminase activity”
(R)-3-amino-2-methylpropionate:pyruvate transaminase activity definition “Catalysis of the reaction: (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine.”
- database_cross_reference “RHEA:18393”
(R)-3-amino-2-methylpropionate:pyruvate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI

(R)-6-hydroxynicotine oxidase activity `http://purl.obolibrary.org/obo/GO_0018530`

Removed

(R)-6-hydroxynicotine oxidase activity SubClassOf obsolete hydroxy-nicotine oxidase activity

Added

(R)-6-hydroxynicotine oxidase activity SubClassOf oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

(R)-mandelate catabolic process to benzoate `http://purl.obolibrary.org/obo/GO_0019597`

Removed

(R)-mandelate catabolic process to benzoate definition “The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including benzoate.”
- database_cross_reference “GOC:go_curators”

Added

(R)-mandelate catabolic process to benzoate definition “The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including benzoate.”
- database_cross_reference “GOC:curators”

(R)-mandelate catabolic process to catechol `http://purl.obolibrary.org/obo/GO_0019598`

Removed

(R)-mandelate catabolic process to catechol definition “The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including catechol.”
- database_cross_reference “GOC:go_curators”

Added

(R)-mandelate catabolic process to catechol definition “The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including catechol.”
- database_cross_reference “GOC:curators”

(R,S)-4-hydroxy-2-oxoglutarate aldolase activity `http://purl.obolibrary.org/obo/GO_0008700`

Added

(RS)-norcoclaurine 6-O-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0030786`

Added

(S)-2-hydroxy-acid oxidase activity `http://purl.obolibrary.org/obo/GO_0003973`

Removed

(S)-2-hydroxy-acid oxidase activity definition “Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide.”
- database_cross_reference “RHEA:16789”

Added

(S)-2-hydroxy-acid oxidase activity definition “Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + H2O2.”
- database_cross_reference “RHEA:16789”
(S)-2-hydroxy-acid oxidase activity database_cross_reference “RHEA:41227”
(S)-2-hydroxy-acid oxidase activity narrowMatch 41227
(S)-2-hydroxy-acid oxidase activity narrowMatch 27662
(S)-2-hydroxy-acid oxidase activity database_cross_reference “RHEA:27662”

(S)-2-hydroxyglutarate dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0047545`

Added

(S)-2-hydroxyglutarate dehydrogenase activity narrowMatch 57172
(S)-2-hydroxyglutarate dehydrogenase activity narrowMatch 30087
(S)-2-hydroxyglutarate dehydrogenase activity database_cross_reference “RHEA:30087”
(S)-2-hydroxyglutarate dehydrogenase activity database_cross_reference “RHEA:57172”

(S)-3-amino-2-methylpropionate:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0047298`

Removed

(S)-3-amino-2-methylpropionate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate.”
- database_cross_reference “EC:2.6.1.22”
- database_cross_reference “RHEA:13993”
(S)-3-amino-2-methylpropionate:2-oxoglutarate transaminase activity label “(S)-3-amino-2-methylpropionate transaminase activity”

Added

(S)-3-amino-2-methylpropionate:2-oxoglutarate transaminase activity label “(S)-3-amino-2-methylpropionate:2-oxoglutarate transaminase activity”
(S)-3-amino-2-methylpropionate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate.”
- database_cross_reference “RHEA:13993”
(S)-3-amino-2-methylpropionate:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
(S)-3-amino-2-methylpropionate:2-oxoglutarate transaminase activity has_exact_synonym “(S)-3-amino-2-methylpropionate transaminase activity”

(S)-6-hydroxynicotine oxidase activity `http://purl.obolibrary.org/obo/GO_0018531`

Removed

(S)-6-hydroxynicotine oxidase activity SubClassOf obsolete hydroxy-nicotine oxidase activity

Added

(S)-6-hydroxynicotine oxidase activity SubClassOf oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

(S)-tetrahydroprotoberberine N-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0030782`

Added

1,2-diacylglycerol 3-beta-galactosyltransferase activity `http://purl.obolibrary.org/obo/GO_0046509`

Added

1,2-dichloroethane catabolic process `http://purl.obolibrary.org/obo/GO_0019260`

Removed

1,2-dichloroethane catabolic process definition “The chemical reactions and pathways resulting in the breakdown of 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride.”
- database_cross_reference “GOC:go_curators”

Added

1,2-dichloroethane catabolic process definition “The chemical reactions and pathways resulting in the breakdown of 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride.”
- database_cross_reference “GOC:curators”

1,4-dihydroxy-2-naphthoate polyprenyltransferase activity `http://purl.obolibrary.org/obo/GO_0046428`

Added

1,4-lactonase activity `http://purl.obolibrary.org/obo/GO_0050490`

Added

1,4-lactonase activity database_cross_reference “RHEA:44900”
1,4-lactonase activity narrowMatch 52648
1,4-lactonase activity database_cross_reference “RHEA:52648”
1,4-lactonase activity narrowMatch 52644
1,4-lactonase activity database_cross_reference “RHEA:52644”
1,4-lactonase activity narrowMatch 44900

1,5-anhydro-D-fructose reductase activity `http://purl.obolibrary.org/obo/GO_0050571`

Added

1,5-anhydro-D-fructose reductase activity database_cross_reference “Reactome:R-HSA-9773976”
- label “AKR1E2 reduces 1,5-aF to 1,5-aG”

1-acylglycerol-3-phosphate O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0003841`

Added

1-acylglycerophosphocholine O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0047184`

Added

1-acylglycerophosphoethanolamine O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0106262`

Added

1-acylglycerophosphoserine O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0106263`

Added

1-alkenylglycerophosphoethanolamine O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0047166`

Added

1-alkyl-2-acetylglycerophosphocholine esterase activity `http://purl.obolibrary.org/obo/GO_0003847`

Added

1-alkylglycerophosphocholine O-acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0047192`

Added

1-alkylglycerophosphocholine O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0047191`

Added

1-aminocyclopropane-1-carboxylate catabolic process `http://purl.obolibrary.org/obo/GO_0042217`

Removed

1-aminocyclopropane-1-carboxylate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants.”
- database_cross_reference “GOC:go_curators”
1-aminocyclopropane-1-carboxylate catabolic process SubClassOf obsolete 1-aminocyclopropane-1-carboxylate metabolic process

Added

1-aminocyclopropane-1-carboxylate catabolic process database_cross_reference “UM-BBD_pathwayID:acp”
1-aminocyclopropane-1-carboxylate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants.”
- database_cross_reference “UM-BBD_pathwayID:acp”

1-aminocyclopropane-1-carboxylate synthase activity `http://purl.obolibrary.org/obo/GO_0016847`

Removed

1-aminocyclopropane-1-carboxylate synthase activity definition “Catalysis of the reaction: S-adenosyl-L-methionine(1+) = 1-aminocyclopropane-1-carboxylate + S-methyl-5’-thioadenosine + H+.”
- database_cross_reference “RHEA:21744”
- database_cross_reference “EC:4.4.1.14”
1-aminocyclopropane-1-carboxylate synthase activity SubClassOf part of some obsolete 1-aminocyclopropane-1-carboxylate biosynthetic process

Added

1-aminocyclopropane-1-carboxylate synthase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31510”^^anyURI
1-aminocyclopropane-1-carboxylate synthase activity definition “Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + S-methyl-5’-thioadenosine + H+. 1-aminocyclopropane-1-carboxylate (ACC) is a direct precursor of ethylene biosynthesis.”
- database_cross_reference “RHEA:21744”
1-aminocyclopropane-1-carboxylate synthase activity SubClassOf part of some ethylene biosynthetic process

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate catabolic process `http://purl.obolibrary.org/obo/GO_1903101`

Removed

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate catabolic process SubClassOf phosphatidylinositol catabolic process

Added

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate catabolic process SubClassOf glycerophospholipid catabolic process

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process `http://purl.obolibrary.org/obo/GO_1903100`

Removed

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process SubClassOf phosphatidylinositol metabolic process

Added

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process SubClassOf glycerophospholipid metabolic process

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process `http://purl.obolibrary.org/obo/GO_1902634`

Removed

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process SubClassOf phosphatidylinositol catabolic process

Added

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process SubClassOf glycerophospholipid catabolic process

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process `http://purl.obolibrary.org/obo/GO_1902633`

Removed

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process SubClassOf phosphatidylinositol metabolic process

Added

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process SubClassOf glycerophospholipid metabolic process

1-phosphatidylinositol 4-kinase activator activity `http://purl.obolibrary.org/obo/GO_0098744`

Added

1-phosphatidylinositol 4-kinase activator activity database_cross_reference “Reactome:R-HSA-1676152”
- label “PI4KB binds to ARF1/3:GTP at the Golgi membrane”

1-phosphatidylinositol binding `http://purl.obolibrary.org/obo/GO_0005545`

Removed

1-phosphatidylinositol binding SubClassOf phosphatidylinositol binding

Added

1-phosphatidylinositol binding SubClassOf phospholipid binding

1-phosphatidylinositol-3-phosphate 5-kinase activity `http://purl.obolibrary.org/obo/GO_0000285`

Added

1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity `http://purl.obolibrary.org/obo/GO_0046934`

Added

1-phosphatidylinositol-4-phosphate 5-kinase activity `http://purl.obolibrary.org/obo/GO_0016308`

Added

1-phosphatidylinositol-5-phosphate 4-kinase activity `http://purl.obolibrary.org/obo/GO_0016309`

Added

11-beta-hydroxysteroid dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0070523`

Added

11-beta-hydroxysteroid dehydrogenase (NAD+) activity database_cross_reference “RHEA:50208”
11-beta-hydroxysteroid dehydrogenase (NAD+) activity database_cross_reference “RHEA:84083”
11-beta-hydroxysteroid dehydrogenase (NAD+) activity narrowMatch 50208
11-beta-hydroxysteroid dehydrogenase (NAD+) activity database_cross_reference “RHEA:42204”
11-beta-hydroxysteroid dehydrogenase (NAD+) activity database_cross_reference “Reactome:R-HSA-194023”
- label “HSD11B2,HSD11B1 dimer oxidise CORT to COR”
11-beta-hydroxysteroid dehydrogenase (NAD+) activity narrowMatch 84083
11-beta-hydroxysteroid dehydrogenase (NAD+) activity narrowMatch 42204
11-beta-hydroxysteroid dehydrogenase (NAD+) activity narrowMatch 69408
11-beta-hydroxysteroid dehydrogenase (NAD+) activity narrowMatch 69368
11-beta-hydroxysteroid dehydrogenase (NAD+) activity database_cross_reference “RHEA:69368”
11-beta-hydroxysteroid dehydrogenase (NAD+) activity database_cross_reference “RHEA:69408”

11-beta-hydroxysteroid dehydrogenase (NADP+) activity `http://purl.obolibrary.org/obo/GO_0070524`

Added

17-beta-hydroxysteroid dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0044594`

Added

17-beta-hydroxysteroid dehydrogenase (NADP+) activity `http://purl.obolibrary.org/obo/GO_0072582`

Added

18S rRNA cytidine N-acetyltransferase activity `http://purl.obolibrary.org/obo/GO_1990883`

Added

18S rRNA cytidine N-acetyltransferase activity SubClassOf catalytic activity, acting on a rRNA

1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate transaminase activity `http://purl.obolibrary.org/obo/GO_0047311`

Removed

1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate transaminase activity definition “Catalysis of the reaction: 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate = 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine.”
- database_cross_reference “RHEA:15497”
- database_cross_reference “EC:2.6.1.56”
1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate transaminase activity label “1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase activity”

Added

1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate transaminase activity definition “Catalysis of the reaction: 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate = 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine.”
- database_cross_reference “RHEA:15497”
1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate transaminase activity has_exact_synonym “1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase activity”
1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate transaminase activity label “1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate transaminase activity”

2’,3’-cyclic-nucleotide 2’-phosphodiesterase activity `http://purl.obolibrary.org/obo/GO_0008663`

Added

2’,3’-cyclic-nucleotide 3’-phosphodiesterase activity `http://purl.obolibrary.org/obo/GO_0004113`

Added

2’-deoxyribonucleoside biosynthetic process `http://purl.obolibrary.org/obo/GO_0046120`

Removed

2’-deoxyribonucleoside biosynthetic process label “deoxyribonucleoside biosynthetic process”

Added

2’-deoxyribonucleoside biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/27059”^^anyURI
2’-deoxyribonucleoside biosynthetic process has_exact_synonym “deoxyribonucleoside biosynthetic process”
2’-deoxyribonucleoside biosynthetic process label “2’-deoxyribonucleoside biosynthetic process”

2’-deoxyribonucleoside catabolic process `http://purl.obolibrary.org/obo/GO_0046121`

Removed

2’-deoxyribonucleoside catabolic process label “deoxyribonucleoside catabolic process”

Added

2’-deoxyribonucleoside catabolic process has_exact_synonym “deoxyribonucleoside catabolic process”
2’-deoxyribonucleoside catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/27059”^^anyURI
2’-deoxyribonucleoside catabolic process label “2’-deoxyribonucleoside catabolic process”

2’-deoxyribonucleoside metabolic process `http://purl.obolibrary.org/obo/GO_0009120`

Removed

2’-deoxyribonucleoside metabolic process label “deoxyribonucleoside metabolic process”

Added

2’-deoxyribonucleoside metabolic process has_exact_synonym “deoxyribonucleoside metabolic process”
2’-deoxyribonucleoside metabolic process label “2’-deoxyribonucleoside metabolic process”
2’-deoxyribonucleoside metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/27059”^^anyURI

2’-deoxyribonucleotide biosynthetic process `http://purl.obolibrary.org/obo/GO_0009265`

Removed

2’-deoxyribonucleotide biosynthetic process SubClassOf deoxyribonucleotide biosynthetic process

Added

2’-deoxyribonucleotide biosynthetic process SubClassOf nucleotide biosynthetic process

2’-deoxyribonucleotide metabolic process `http://purl.obolibrary.org/obo/GO_0009394`

Removed

2’-deoxyribonucleotide metabolic process SubClassOf deoxyribonucleotide metabolic process

Added

2,4-diaminopentanoate dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0047530`

Removed

2,4-diaminopentanoate dehydrogenase activity definition “Catalysis of the reaction: 2,4-diaminopentanoate + H2O + NAD(P)+ = 2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+.”
- database_cross_reference “EC:1.4.1.12”
- database_cross_reference “MetaCyc:24-DIAMINOPENTANOATE-DEHYDROGENASE-RXN”

Added

2,4-diaminopentanoate dehydrogenase activity definition “Catalysis of the reaction: (2R,4S)-2,4-diaminopentanoate + NADP+ + H2O = (2R)-2-amino-4-oxopentanoate + NH4+ + NADPH + H+.”
- database_cross_reference “EC:1.4.1.12”
2,4-diaminopentanoate dehydrogenase activity database_cross_reference “RHEA:24192”
2,4-diaminopentanoate dehydrogenase activity database_cross_reference “RHEA:24196”
2,4-diaminopentanoate dehydrogenase activity narrowMatch 24196
2,4-diaminopentanoate dehydrogenase activity narrowMatch 24192

2-(acetamidomethylene)succinate hydrolase activity `http://purl.obolibrary.org/obo/GO_0047411`

Removed

2-(acetamidomethylene)succinate hydrolase activity definition “Catalysis of the reaction: 2 H2O + 2-(acetamidomethylene)succinate = CO2 + NH3 + succinate semialdehyde + acetate.”
- database_cross_reference “EC:3.5.1.29”
- database_cross_reference “MetaCyc:3.5.1.29-RXN”

Added

2-(acetamidomethylene)succinate hydrolase activity definition “Catalysis of the reaction: 2-(acetamidomethylene)succinate + 2 H2O + H+ = succinate semialdehyde + acetate + NH4+ + CO2.”
- database_cross_reference “RHEA:10432”

2-acylglycerol O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0003846`

Added

2-acylglycerol O-acyltransferase activity database_cross_reference “RHEA:77283”
2-acylglycerol O-acyltransferase activity database_cross_reference “RHEA:77291”
2-acylglycerol O-acyltransferase activity database_cross_reference “RHEA:77287”
2-acylglycerol O-acyltransferase activity database_cross_reference “RHEA:77271”
2-acylglycerol O-acyltransferase activity narrowMatch 77287
2-acylglycerol O-acyltransferase activity database_cross_reference “RHEA:77543”
2-acylglycerol O-acyltransferase activity database_cross_reference “RHEA:39951”
2-acylglycerol O-acyltransferase activity narrowMatch 38467
2-acylglycerol O-acyltransferase activity database_cross_reference “RHEA:77279”
2-acylglycerol O-acyltransferase activity database_cross_reference “RHEA:38467”
2-acylglycerol O-acyltransferase activity database_cross_reference “RHEA:77275”
2-acylglycerol O-acyltransferase activity database_cross_reference “RHEA:77539”
2-acylglycerol O-acyltransferase activity narrowMatch 77543
2-acylglycerol O-acyltransferase activity narrowMatch 77291
2-acylglycerol O-acyltransferase activity narrowMatch 39951
2-acylglycerol O-acyltransferase activity narrowMatch 77539
2-acylglycerol O-acyltransferase activity narrowMatch 77283
2-acylglycerol O-acyltransferase activity narrowMatch 77275
2-acylglycerol O-acyltransferase activity narrowMatch 77279
2-acylglycerol O-acyltransferase activity narrowMatch 77547
2-acylglycerol O-acyltransferase activity database_cross_reference “RHEA:77547”
2-acylglycerol O-acyltransferase activity narrowMatch 77271

2-acylglycerophosphocholine O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0047190`

Added

2-aminoethylphosphonate catabolic process `http://purl.obolibrary.org/obo/GO_0019635`

Added

2-aminoethylphosphonate catabolic process narrowMatch PWY-6832
2-aminoethylphosphonate catabolic process narrowMatch PWY-7447
2-aminoethylphosphonate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
2-aminoethylphosphonate catabolic process database_cross_reference “MetaCyc:PWY-6832”
2-aminoethylphosphonate catabolic process database_cross_reference “MetaCyc:PWY-7447”
2-aminoethylphosphonate catabolic process narrowMatch PHOSPHONOTASE-PWY

2-aminoethylphosphonate:pyruvate transaminase activity `http://purl.obolibrary.org/obo/GO_0047304`

Removed

2-aminoethylphosphonate:pyruvate transaminase activity definition “Catalysis of the reaction: (2-aminoethyl)phosphonate + pyruvate = L-alanine + phosphonoacetaldehyde.”
- database_cross_reference “EC:2.6.1.37”
- database_cross_reference “RHEA:17021”
2-aminoethylphosphonate:pyruvate transaminase activity label “2-aminoethylphosphonate-pyruvate transaminase activity”

Added

2-aminoethylphosphonate:pyruvate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
2-aminoethylphosphonate:pyruvate transaminase activity definition “Catalysis of the reaction: (2-aminoethyl)phosphonate + pyruvate = L-alanine + phosphonoacetaldehyde.”
- database_cross_reference “RHEA:17021”
2-aminoethylphosphonate:pyruvate transaminase activity has_exact_synonym “2-aminoethylphosphonate-pyruvate transaminase activity”
2-aminoethylphosphonate:pyruvate transaminase activity label “2-aminoethylphosphonate:pyruvate transaminase activity”

2-furoate-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0047541`

Removed

2-furoate-CoA ligase activity SubClassOf acid-thiol ligase activity

2-halobenzoate 1,2-dioxygenase activity `http://purl.obolibrary.org/obo/GO_0018626`

Added

2-halobenzoate 1,2-dioxygenase activity narrowMatch 21652
2-halobenzoate 1,2-dioxygenase activity database_cross_reference “RHEA:21652”

2-iminobutanoate deaminase activity `http://purl.obolibrary.org/obo/GO_0120242`

Removed

2-iminobutanoate deaminase activity definition “Catalysis of the reaction: 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+).”
- database_cross_reference “RHEA:39975”

Added

2-iminobutanoate deaminase activity database_cross_reference “Reactome:R-HSA-9014641”
- label “HRSP12 deaminates 2-iminobutanoate to 2OBUTA”
2-iminobutanoate deaminase activity definition “Catalysis of the reaction: 2-iminobutanoate + H2O = 2-oxobutanoate + NH4+.”
- database_cross_reference “RHEA:39975”

2-iminopropanoate deaminase activity `http://purl.obolibrary.org/obo/GO_0120243`

Removed

2-iminopropanoate deaminase activity definition “Catalysis of the reaction: 2-iminopropanoate + H2O = NH4(+) + pyruvate.”
- database_cross_reference “RHEA:40671”

Added

2-iminopropanoate deaminase activity definition “Catalysis of the reaction: 2-iminopropanoate + H2O = NH4+ + pyruvate.”
- database_cross_reference “RHEA:40671”

2-keto-3-deoxygluconate transmembrane transport `http://purl.obolibrary.org/obo/GO_0046411`

Removed

2-keto-3-deoxygluconate transmembrane transport definition “The process in which 2-keto-3-deoxygluconate is transported across a lipid bilayer, from one side of a membrane to the other.”
- database_cross_reference “GOC:go_curators”

Added

2-keto-3-deoxygluconate transmembrane transport definition “The process in which 2-keto-3-deoxygluconate is transported across a lipid bilayer, from one side of a membrane to the other.”
- database_cross_reference “GOC:curators”

2-methoxy-6-polyprenolphenol 4-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0120538`

Added

2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity `http://purl.obolibrary.org/obo/GO_0008425`

Added

2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity `http://purl.obolibrary.org/obo/GO_0018855`

Removed

2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity SubClassOf acid-thiol ligase activity

2-oxoaldehyde dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0047551`

Added

2-oxobutyrate catabolic process `http://purl.obolibrary.org/obo/GO_0019606`

Added

2-oxobutyrate catabolic process narrowMatch OXOBUTYRATECAT-PWY
2-oxobutyrate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
2-oxobutyrate catabolic process database_cross_reference “MetaCyc:PWY-5130”
2-oxobutyrate catabolic process narrowMatch PWY-5130

2-polyprenyl-6-hydroxyphenol methylase activity `http://purl.obolibrary.org/obo/GO_0102208`

Added

2-polyprenylphenol 6-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0019168`

Added

2-polyprenylphenol 6-hydroxylase activity database_cross_reference “RHEA:56116”
2-polyprenylphenol 6-hydroxylase activity database_cross_reference “RHEA:56120”
2-polyprenylphenol 6-hydroxylase activity narrowMatch 56112
2-polyprenylphenol 6-hydroxylase activity narrowMatch 56116
2-polyprenylphenol 6-hydroxylase activity database_cross_reference “RHEA:56112”
2-polyprenylphenol 6-hydroxylase activity database_cross_reference “RHEA:27790”
2-polyprenylphenol 6-hydroxylase activity narrowMatch 56120
2-polyprenylphenol 6-hydroxylase activity narrowMatch 27790

23S rRNA (adenosine(1067)-2’-O-ribose)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0030743`

Removed

23S rRNA (adenosine(1067)-2’-O-ribose)-methyltransferase activity label “23S rRNA (adenosine(1067)-2’-O)-methyltransferase activity”

Added

23S rRNA (adenosine(1067)-2’-O-ribose)-methyltransferase activity has_exact_synonym “23S rRNA (adenosine(1067)-2’-O)-methyltransferase activity”
23S rRNA (adenosine(1067)-2’-O-ribose)-methyltransferase activity label “23S rRNA (adenosine(1067)-2’-O-ribose)-methyltransferase activity”

3’ overhang single-stranded DNA endonuclease activity `http://purl.obolibrary.org/obo/GO_1990599`

Removed

3’ overhang single-stranded DNA endonuclease activity label “3’ overhang single-stranded DNA endodeoxyribonuclease activity”

Added

3’ overhang single-stranded DNA endonuclease activity has_exact_synonym “3’ overhang single-stranded DNA endodeoxyribonuclease activity”
3’ overhang single-stranded DNA endonuclease activity term tracker item “https://github.com/geneontology/go-ontology/issues/31721”^^anyURI
3’ overhang single-stranded DNA endonuclease activity label “3’ overhang single-stranded DNA endonuclease activity”

3’,5’-cyclic-nucleotide phosphodiesterase activity `http://purl.obolibrary.org/obo/GO_0004114`

Added

3’-5’-RNA exonuclease activity `http://purl.obolibrary.org/obo/GO_0000175`

Removed

3’-5’-RNA exonuclease activity database_cross_reference “Reactome:R-HSA-6791227”
- label “47S pre-rRNA is nucleolytically processed at A’ (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA”

Added

3’-5’-RNA exonuclease activity database_cross_reference “Reactome:R-HSA-9933585”
- label “RNA exosome in PAXT:PAPOLG:TENT4A,B:ZC3H3:CBCA:polyadenylated m7GpppN-RNA:PABPN1 hydrolyzes RNA”
3’-5’-RNA exonuclease activity database_cross_reference “Reactome:R-HSA-9934763”
- label “The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA”
3’-5’-RNA exonuclease activity database_cross_reference “Reactome:R-HSA-9935824”
- label “TRAMP:RNA exosome hydrolyzes oligoadenylated pre-rRNA 5’ external transcribed spacer (5’ETS)”

3’-nucleotidase activity `http://purl.obolibrary.org/obo/GO_0008254`

Added

3’-nucleotidase activity narrowMatch 27862
3’-nucleotidase activity database_cross_reference “RHEA:27898”
3’-nucleotidase activity narrowMatch 27894
3’-nucleotidase activity database_cross_reference “RHEA:27890”
3’-nucleotidase activity database_cross_reference “RHEA:27862”
3’-nucleotidase activity narrowMatch 27898
3’-nucleotidase activity narrowMatch 27890
3’-nucleotidase activity database_cross_reference “RHEA:27894”

3’-phosphoadenosine 5’-phosphosulfate metabolic process `http://purl.obolibrary.org/obo/GO_0050427`

Added

3’-phosphoadenosine 5’-phosphosulfate metabolic process database_cross_reference “Reactome:R-HSA-174362”
- label “Transport and metabolism of PAPS”

3’-phosphoadenosine 5’-phosphosulfate transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0046964`

Removed

3’-phosphoadenosine 5’-phosphosulfate transmembrane transporter activity database_cross_reference “Reactome:R-HSA-741449”
- label “SLC35B2,3 transport cytosolic PAPS to Golgi lumen”

Added

3’-phosphoadenosine 5’-phosphosulfate transmembrane transporter activity database_cross_reference “Reactome:R-HSA-741449”
- label “SLC35B2,3 exchange cytosolic PAPS with Golgi PAP”

3,5-diiodo-L-tyrosine:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0047861`

Removed

3,5-diiodo-L-tyrosine:2-oxoglutarate transaminase activity label “diiodotyrosine transaminase activity”
3,5-diiodo-L-tyrosine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + 3,5-diiodo-L-tyrosine = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate.”
- database_cross_reference “EC:2.6.1.24”
- database_cross_reference “RHEA:19781”

Added

3,5-diiodo-L-tyrosine:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
3,5-diiodo-L-tyrosine:2-oxoglutarate transaminase activity label “3,5-diiodo-L-tyrosine:2-oxoglutarate transaminase activity”
3,5-diiodo-L-tyrosine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + 3,5-diiodo-L-tyrosine = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate.”
- database_cross_reference “RHEA:19781”

3-alpha,7-alpha-dihydroxy-5-beta-cholestanate-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0047476`

Removed

3-alpha,7-alpha-dihydroxy-5-beta-cholestanate-CoA ligase activity SubClassOf acid-thiol ligase activity

3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity `http://purl.obolibrary.org/obo/GO_0000253`

Added

3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity narrowMatch 85563
3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity database_cross_reference “Reactome:R-HSA-9945784”
- label “HSD17B7 reduces 4a-methyl-5a-cholest-8-en-3-one to 4a-methyl-5a-cholest-8-en-3b-ol”
3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity database_cross_reference “RHEA:56916”
3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity narrowMatch 69036
3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity narrowMatch 46852
3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity narrowMatch 85555
3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity narrowMatch 46832
3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity database_cross_reference “RHEA:69012”
3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity narrowMatch 56916
3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity database_cross_reference “RHEA:33459”
3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity database_cross_reference “RHEA:46216”
3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity database_cross_reference “RHEA:56880”
3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity database_cross_reference “RHEA:85555”
3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity database_cross_reference “RHEA:46852”
3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity database_cross_reference “Reactome:R-HSA-9945804”
- label “HSD17B7 reduces 5a-cholest-8-en-3-one to ZYMSTNL”
3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity narrowMatch 56880
3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity narrowMatch 69012
3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity narrowMatch 33459
3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity database_cross_reference “RHEA:85563”
3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity narrowMatch 46216
3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity database_cross_reference “RHEA:69036”
3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity database_cross_reference “RHEA:46832”

3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity `http://purl.obolibrary.org/obo/GO_0102175`

Added

3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity `http://purl.obolibrary.org/obo/GO_0000252`

Added

3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity database_cross_reference “Reactome:R-HSA-9945787”
- label “NSDHL decarboxylates 4a-carboxy-5a-cholest-8-ene-3b-ol to 5a-cholest-8-en-3-one”
3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity database_cross_reference “Reactome:R-HSA-9945822”
- label “NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol”

3-chloro-D-alanine dehydrochlorinase activity `http://purl.obolibrary.org/obo/GO_0019149`

Removed

3-chloro-D-alanine dehydrochlorinase activity definition “Catalysis of the reaction: 3-chloro-D-alanine + H2O = pyruvate + chloride + NH3.”
- database_cross_reference “EC:4.5.1.2”

Added

3-chloro-D-alanine dehydrochlorinase activity definition “Catalysis of the reaction: 3-chloro-D-alanine + H2O = chloride + pyruvate + NH4+ + H+.”
- database_cross_reference “RHEA:18873”

3-demethoxyubiquinone 3-hydroxylase (NADH) activity `http://purl.obolibrary.org/obo/GO_0160224`

Added

3-demethylubiquinol 3-O-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0061542`

Added

3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity `http://purl.obolibrary.org/obo/GO_0017060`

Added

3-hydroxyacyl-CoA dehydratase activity `http://purl.obolibrary.org/obo/GO_0018812`

Added

3-hydroxyacyl-CoA dehydratase activity narrowMatch 35355
3-hydroxyacyl-CoA dehydratase activity database_cross_reference “RHEA:35355”
3-hydroxyacyl-CoA dehydratase activity narrowMatch 35347
3-hydroxyacyl-CoA dehydratase activity database_cross_reference “RHEA:46348”
3-hydroxyacyl-CoA dehydratase activity database_cross_reference “RHEA:35347”
3-hydroxyacyl-CoA dehydratase activity narrowMatch 46352
3-hydroxyacyl-CoA dehydratase activity narrowMatch 35359
3-hydroxyacyl-CoA dehydratase activity database_cross_reference “RHEA:35359”
3-hydroxyacyl-CoA dehydratase activity database_cross_reference “RHEA:46352”
3-hydroxyacyl-CoA dehydratase activity narrowMatch 46348

3-hydroxyisobutyrate dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0008442`

Added

3-hydroxyisobutyrate dehydrogenase activity narrowMatch 31275
3-hydroxyisobutyrate dehydrogenase activity narrowMatch 56972
3-hydroxyisobutyrate dehydrogenase activity database_cross_reference “RHEA:31275”
3-hydroxyisobutyrate dehydrogenase activity database_cross_reference “RHEA:56972”

3-hydroxyphenylpropionic acid transmembrane transport `http://purl.obolibrary.org/obo/GO_0042920`

Removed

3-hydroxyphenylpropionic acid transmembrane transport definition “The directed movement of 3-hydroxyphenylpropionic acid across a lipid bilayer, from one side of a membrane to the other.”
- database_cross_reference “PMID:9098055”
- database_cross_reference “GOC:go_curators”

Added

3-hydroxyphenylpropionic acid transmembrane transport definition “The directed movement of 3-hydroxyphenylpropionic acid across a lipid bilayer, from one side of a membrane to the other.”
- database_cross_reference “PMID:9098055”
- database_cross_reference “GOC:curators”

3-hydroxypropionyl-CoA synthetase activity `http://purl.obolibrary.org/obo/GO_0043955`

Removed

3-hydroxypropionyl-CoA synthetase activity SubClassOf acid-thiol ligase activity

3-mercaptopyruvate sulfurtransferase activity `http://purl.obolibrary.org/obo/GO_0016784`

Removed

3-mercaptopyruvate sulfurtransferase activity database_cross_reference “Reactome:R-HSA-9013471”
- label “MPST transfers sulfur from 3MPYR to HCN to form HSCN”
3-mercaptopyruvate sulfurtransferase activity database_cross_reference “Reactome:R-HSA-9034756”
- label “MPST transfers sulfur atom from 3MPYR to form CysS248-MPST”
3-mercaptopyruvate sulfurtransferase activity database_cross_reference “Reactome:R-HSA-9013533”
- label “MPST transfers sulfur from sulfanegen to HCN to form HSCN”
3-mercaptopyruvate sulfurtransferase activity database_cross_reference “Reactome:R-HSA-9012721”
- label “MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR”

3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity `http://purl.obolibrary.org/obo/GO_0047751`

Added

3-oxo-5-alpha-steroid 4-dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0003865`

Added

3-oxoacyl-[acyl-carrier-protein] synthase activity `http://purl.obolibrary.org/obo/GO_0004315`

Added

3-oxosteroid 1-dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0047571`

Added

3-oxosteroid 1-dehydrogenase activity database_cross_reference “RHEA:51052”
3-oxosteroid 1-dehydrogenase activity narrowMatch 51052

3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0033792`

Added

4-aminobutyrate:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0034386`

Added

4-aminobutyrate:2-oxoglutarate transaminase activity database_cross_reference “Reactome:R-HSA-916855”
- label “PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA”

4-chloro-allylglycine synthase activity `http://purl.obolibrary.org/obo/GO_0062146`

Removed

4-chloro-allylglycine synthase activity definition “Catalysis of the reaction: 4-chloro-L-lysine + AH2 + O2 = A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+).”
- database_cross_reference “RHEA:59888”
- database_cross_reference “PMID:30867596”

Added

4-chloro-allylglycine synthase activity definition “Catalysis of the reaction: 4-chloro-L-lysine + AH2 + O2 = A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4+.”
- database_cross_reference “RHEA:59888”
- database_cross_reference “PMID:30867596”

4-chlorobenzoate-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0018861`

Removed

4-chlorobenzoate-CoA ligase activity SubClassOf acid-thiol ligase activity

4-coumarate-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0016207`

Removed

4-coumarate-CoA ligase activity SubClassOf acid-thiol ligase activity

4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity `http://purl.obolibrary.org/obo/GO_0017083`

Added

4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity `http://purl.obolibrary.org/obo/GO_0106364`

Added

4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity `http://purl.obolibrary.org/obo/GO_0120539`

Added

4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity narrowMatch 81271
4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity database_cross_reference “RHEA:44768”
4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity narrowMatch 81267
4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity narrowMatch 81263
4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity narrowMatch 81275
4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity database_cross_reference “RHEA:81275”
4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity narrowMatch 44768
4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity database_cross_reference “RHEA:81271”
4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity database_cross_reference “Reactome:R-HSA-2162195”
- label “COQ4 decarboxylates MHDB”
4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity database_cross_reference “RHEA:81267”
4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity database_cross_reference “RHEA:81263”

4-hydroxy-3-polyprenylbenzoate decarboxylase activity `http://purl.obolibrary.org/obo/GO_0008694`

Added

4-hydroxybenzoate polyprenyltransferase activity `http://purl.obolibrary.org/obo/GO_0008412`

Added

4-hydroxybenzoate polyprenyltransferase activity database_cross_reference “RHEA:44556”
4-hydroxybenzoate polyprenyltransferase activity database_cross_reference “Reactome:R-HSA-2162192”
- label “COQ2 ligates all-E-10PrP2 to PHB”
4-hydroxybenzoate polyprenyltransferase activity narrowMatch 27782
4-hydroxybenzoate polyprenyltransferase activity narrowMatch 44556
4-hydroxybenzoate polyprenyltransferase activity narrowMatch 17709
4-hydroxybenzoate polyprenyltransferase activity narrowMatch 44564
4-hydroxybenzoate polyprenyltransferase activity database_cross_reference “RHEA:44560”
4-hydroxybenzoate polyprenyltransferase activity database_cross_reference “RHEA:27782”
4-hydroxybenzoate polyprenyltransferase activity narrowMatch 44560
4-hydroxybenzoate polyprenyltransferase activity database_cross_reference “RHEA:17709”
4-hydroxybenzoate polyprenyltransferase activity database_cross_reference “RHEA:44564”

4-hydroxybenzoate-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0018859`

Removed

4-hydroxybenzoate-CoA ligase activity SubClassOf acid-thiol ligase activity

4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0120521`

Added

4-methylaminobutyrate oxidase (demethylating) activity `http://purl.obolibrary.org/obo/GO_0102317`

Removed

4-methylaminobutyrate oxidase (demethylating) activity definition “Catalysis of the reaction: 4-(methylamino)butyric acid + O2 + H2O = gamma-aminobutyric acid + formaldehyde + hydrogen peroxide.”
- database_cross_reference “GOC:pz”
- database_cross_reference “EC:1.5.3.19”

Added

4-methylaminobutyrate oxidase (demethylating) activity definition “Catalysis of the reaction: 4-(methylamino)butanoate + O2 + H2O = 4-aminobutanoate + formaldehyde + H2O2.”
- database_cross_reference “RHEA:33907”

4-nitrotoluene catabolic process `http://purl.obolibrary.org/obo/GO_0019258`

Added

4-nitrotoluene catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
4-nitrotoluene catabolic process database_cross_reference “MetaCyc:PWY-5644”
4-nitrotoluene catabolic process narrowMatch PWY-5644
4-nitrotoluene catabolic process narrowMatch P421-PWY

4-vinylphenol methyltransferase activity `http://purl.obolibrary.org/obo/GO_0160304`

Removed

4-vinylphenol methyltransferase activity definition “Catalysis of the reaction: 4-vinylphenol + S-adenosyl-L-methionine = 4-vinylanisole + S-adenosyl-L-homocysteine + H+.”
- database_cross_reference “PMID:40562929”

Added

4-vinylphenol methyltransferase activity database_cross_reference “RHEA:86075”
4-vinylphenol methyltransferase activity exactMatch 86075
4-vinylphenol methyltransferase activity definition “Catalysis of the reaction: 4-vinylphenol + S-adenosyl-L-methionine = 4-vinylanisole + S-adenosyl-L-homocysteine + H+.”
- database_cross_reference “RHEA:86075”
- database_cross_reference “PMID:40562929”

5’ overhang single-stranded DNA endonuclease activity `http://purl.obolibrary.org/obo/GO_1990601`

Removed

5’ overhang single-stranded DNA endonuclease activity label “5’ overhang single-stranded DNA endodeoxyribonuclease activity”

Added

5’ overhang single-stranded DNA endonuclease activity has_exact_synonym “5’ overhang single-stranded DNA endodeoxyribonuclease activity”
5’ overhang single-stranded DNA endonuclease activity term tracker item “https://github.com/geneontology/go-ontology/issues/31721”^^anyURI
5’ overhang single-stranded DNA endonuclease activity label “5’ overhang single-stranded DNA endonuclease activity”

5’-(N(7)-methylguanosine 5’-triphospho)-[mRNA] hydrolase activity `http://purl.obolibrary.org/obo/GO_0140933`

Added

5’-3’ DNA helicase activity `http://purl.obolibrary.org/obo/GO_0043139`

Added

5’-3’ DNA helicase activity database_cross_reference “Reactome:R-HSA-9914438”
- label “TWNK (PEO1) unwinds double-stranded mitochondrial DNA at the replication fork”

5’-3’ RNA exonuclease activity `http://purl.obolibrary.org/obo/GO_0004534`

Added

5’-3’ RNA exonuclease activity database_cross_reference “Reactome:R-HSA-9915442”
- label “EXOG cleaves RNA dinucleotide from nascent mitochondrial DNA”
5’-3’ RNA exonuclease activity database_cross_reference “Reactome:R-HSA-6791227”
- label “47S pre-rRNA is nucleolytically processed at A’ (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA”
5’-3’ RNA exonuclease activity database_cross_reference “Reactome:R-HSA-9946917”
- label “XRN1 incompletely hydrolyzes DENV decapped mRNA”
5’-3’ RNA exonuclease activity database_cross_reference “Reactome:R-HSA-9971054”
- label “XRN2 degrades downstream RNA fragment, promoting transcription termination”
5’-3’ RNA exonuclease activity database_cross_reference “Reactome:R-HSA-9935265”
- label “DXO hydrolyzes uncapped RNA”
5’-3’ RNA exonuclease activity database_cross_reference “Reactome:R-HSA-9935299”
- label “XRN2 5’-3’ exonucleolytically hydrolyzes uncapped RNA”

5’-deoxyadenosine deaminase activity `http://purl.obolibrary.org/obo/GO_0090613`

Removed

5’-deoxyadenosine deaminase activity definition “Catalysis of the reaction: 5’deoxyadenosine + H2O = 5’deoxyinosine + NH3.”
- database_cross_reference “RHEA:42892”
- database_cross_reference “PMID:23968233”

Added

5’-deoxyadenosine deaminase activity definition “Catalysis of the reaction: 5’-deoxyadenosine + H2O + H+ = 5’-deoxyinosine + NH4+.”
- database_cross_reference “RHEA:42892”
- database_cross_reference “PMID:23968233”

5’-deoxynucleotidase activity `http://purl.obolibrary.org/obo/GO_0002953`

Added

5’-deoxynucleotidase activity narrowMatch 29371
5’-deoxynucleotidase activity narrowMatch 29379
5’-deoxynucleotidase activity database_cross_reference “RHEA:29379”
5’-deoxynucleotidase activity narrowMatch 29355
5’-deoxynucleotidase activity narrowMatch 29383
5’-deoxynucleotidase activity narrowMatch 29363
5’-deoxynucleotidase activity narrowMatch 11080
5’-deoxynucleotidase activity database_cross_reference “RHEA:11080”
5’-deoxynucleotidase activity database_cross_reference “RHEA:29363”
5’-deoxynucleotidase activity database_cross_reference “RHEA:29371”
5’-deoxynucleotidase activity database_cross_reference “RHEA:29383”
5’-deoxynucleotidase activity database_cross_reference “RHEA:29355”

5’-flap endonuclease activity `http://purl.obolibrary.org/obo/GO_0017108`

Added

5’-flap endonuclease activity database_cross_reference “Reactome:R-HSA-9914870”
- label “MGME1 cleaves 5’ DNA flap from nascent mitochondrial DNA”

5’-methylthioadenosine deaminase activity `http://purl.obolibrary.org/obo/GO_0090614`

Removed

5’-methylthioadenosine deaminase activity definition “Catalysis of the reaction: 5’methyl thioadenosine + H2O = 5’methyl thioinosine + NH3.”
- database_cross_reference “PMID:23968233”
- database_cross_reference “RHEA:25025”

Added

5’-methylthioadenosine deaminase activity definition “Catalysis of the reaction: S-methyl-5’-thioadenosine + H2O + H+ = S-methyl-5’-thioinosine + NH4+.”
- database_cross_reference “PMID:23968233”
- database_cross_reference “RHEA:25025”

5’-nucleotidase activity `http://purl.obolibrary.org/obo/GO_0008253`

Added

5’-nucleotidase activity database_cross_reference “RHEA:29375”
5’-nucleotidase activity database_cross_reference “RHEA:27714”
5’-nucleotidase activity database_cross_reference “RHEA:30815”
5’-nucleotidase activity narrowMatch 27714
5’-nucleotidase activity database_cross_reference “RHEA:27718”
5’-nucleotidase activity database_cross_reference “RHEA:29359”
5’-nucleotidase activity narrowMatch 29359
5’-nucleotidase activity narrowMatch 27718
5’-nucleotidase activity narrowMatch 30815
5’-nucleotidase activity narrowMatch 29375

5-aminopentanamidase activity `http://purl.obolibrary.org/obo/GO_0047588`

Removed

5-aminopentanamidase activity definition “Catalysis of the reaction: 5-aminopentanamide + H2O = 5-aminopentanoate + NH3.”
- database_cross_reference “MetaCyc:5-AMINOPENTANAMIDASE-RXN”
- database_cross_reference “EC:3.5.1.30”

Added

5-aminopentanamidase activity definition “Catalysis of the reaction: 5-aminopentanamide + H2O = 5-aminopentanoate + NH4+.”
- database_cross_reference “RHEA:15677”

5-aminovalerate:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0047589`

Removed

5-aminovalerate:2-oxoglutarate transaminase activity label “5-aminovalerate transaminase activity”
5-aminovalerate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + 5-aminopentanoate = 5-oxopentanoate + L-glutamate.”
- database_cross_reference “RHEA:10212”
- database_cross_reference “EC:2.6.1.48”

Added

5-aminovalerate:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
5-aminovalerate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 5-aminopentanoate + 2-oxoglutarate = 5-oxopentanoate + L-glutamate.”
- database_cross_reference “RHEA:10212”
5-aminovalerate:2-oxoglutarate transaminase activity label “5-aminovalerate:2-oxoglutarate transaminase activity”
5-aminovalerate:2-oxoglutarate transaminase activity has_exact_synonym “5-aminovalerate transaminase activity”

5-hydroxyfuranocoumarin 5-O-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0030752`

Added

5-phosphoribose 1-diphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0006015`

Removed

5-phosphoribose 1-diphosphate biosynthetic process database_cross_reference “Reactome:R-HSA-73843”
- label “5-Phosphoribose 1-diphosphate biosynthesis”

Added

5-phosphoribose 1-diphosphate biosynthetic process database_cross_reference “MetaCyc:PWY0-662”
5-phosphoribose 1-diphosphate biosynthetic process narrowMatch PWY0-662
5-phosphoribose 1-diphosphate biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI

6-aminohexanoate:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0018719`

Removed

6-aminohexanoate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 6-aminohexanoate + alpha-ketoglutarate = glutamate + 6-oxohexanoate.”
- database_cross_reference “UM-BBD_reactionID:r0449”
6-aminohexanoate:2-oxoglutarate transaminase activity label “6-aminohexanoate transaminase activity”

Added

6-aminohexanoate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 6-aminohexanoate + 2-oxoglutarate = 6-oxohexanoate + L-glutamate.”
- database_cross_reference “RHEA:58200”
6-aminohexanoate:2-oxoglutarate transaminase activity exactMatch 58200
6-aminohexanoate:2-oxoglutarate transaminase activity has_exact_synonym “6-aminohexanoate aminotransferase activity”
6-aminohexanoate:2-oxoglutarate transaminase activity database_cross_reference “EC:2.6.1.116”
6-aminohexanoate:2-oxoglutarate transaminase activity exactMatch 2.6.1.116
6-aminohexanoate:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
6-aminohexanoate:2-oxoglutarate transaminase activity label “6-aminohexanoate:2-oxoglutarate transaminase activity”
6-aminohexanoate:2-oxoglutarate transaminase activity database_cross_reference “RHEA:58200”

6-carboxyhexanoate-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0042410`

Removed

6-carboxyhexanoate-CoA ligase activity SubClassOf acid-thiol ligase activity

6-carboxymethyl-5-methyl-4-hydroxypyridin-2-ol 3-C-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0160302`

Removed

6-carboxymethyl-5-methyl-4-hydroxypyridin-2-ol 3-C-methyltransferase activity definition “Catalysis of the reaction: 6-carboxymethyl-5-methyl-4-hydroxypyridin-2-ol + S-adenosyl-L-methionine = 6-carboxymethyl-3,5-dimethyl-4-hydroxypyridin-2-ol + S-adenosyl-L-homocysteine + H+.”
- database_cross_reference “PMID:27391308”

Added

6-carboxymethyl-5-methyl-4-hydroxypyridin-2-ol 3-C-methyltransferase activity database_cross_reference “RHEA:85483”
6-carboxymethyl-5-methyl-4-hydroxypyridin-2-ol 3-C-methyltransferase activity definition “Catalysis of the reaction: 6-carboxymethyl-5-methyl-4-hydroxypyridin-2-ol + S-adenosyl-L-methionine = 6-carboxymethyl-3,5-dimethyl-4-hydroxypyridin-2-ol + S-adenosyl-L-homocysteine + H+.”
- database_cross_reference “RHEA:85483”
- database_cross_reference “PMID:27391308”
6-carboxymethyl-5-methyl-4-hydroxypyridin-2-ol 3-C-methyltransferase activity exactMatch 85483

6-phospho-beta-galactosidase activity `http://purl.obolibrary.org/obo/GO_0033920`

Added

6-phospho-beta-galactosidase activity narrowMatch 42404
6-phospho-beta-galactosidase activity database_cross_reference “RHEA:42404”

6-phosphofructo-2-kinase activity `http://purl.obolibrary.org/obo/GO_0003873`

Removed

6-phosphofructo-2-kinase activity database_cross_reference “Reactome:R-HSA-71802”
- label “D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP”

Added

6-phosphofructo-2-kinase activity database_cross_reference “Reactome:R-HSA-71802”
- label “PFKFKB dimer phosphorylates Fru(6)P”

6-phosphofructokinase activity `http://purl.obolibrary.org/obo/GO_0003872`

Removed

6-phosphofructokinase activity database_cross_reference “Reactome:R-HSA-70467”
- label “D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP”

Added

6-phosphofructokinase activity database_cross_reference “Reactome:R-HSA-70467”
- label “PFK tetramer phosphorylates Fru(6)P”

6-phosphogluconolactonase activity `http://purl.obolibrary.org/obo/GO_0017057`

Removed

6-phosphogluconolactonase activity database_cross_reference “Reactome:R-HSA-71296”
- label “D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate”

Added

6-phosphogluconolactonase activity database_cross_reference “Reactome:R-HSA-71296”
- label “PGLS hydrolyzes D-glucono-1,5-lactone 6-phosphate”

7-beta-hydroxysteroid dehydrogenase (NADP+) activity `http://purl.obolibrary.org/obo/GO_0047022`

Added

ABC-type glutathione S-conjugate transporter activity `http://purl.obolibrary.org/obo/GO_0015431`

Added

ABC-type oligopeptide transporter activity `http://purl.obolibrary.org/obo/GO_0015421`

Added

ABC-type oligopeptide transporter activity database_cross_reference “RHEA:29763”
ABC-type oligopeptide transporter activity narrowMatch 29763

ABC-type quaternary ammonium compound transporting activity `http://purl.obolibrary.org/obo/GO_0015418`

Added

ABC-type xenobiotic transporter activity `http://purl.obolibrary.org/obo/GO_0008559`

Added

ABC-type xenobiotic transporter activity database_cross_reference “Reactome:R-HSA-9911514”
- label “MacA:MacB:TolC transports azithromycin from the cytosol to the periplasm”

ADP catabolic process `http://purl.obolibrary.org/obo/GO_0046032`

Removed

ADP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5’-diphosphate.”
- database_cross_reference “GOC:go_curators”

Added

ADP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5’-diphosphate.”
- database_cross_reference “GOC:curators”

ADP deaminase activity `http://purl.obolibrary.org/obo/GO_0047629`

Removed

ADP deaminase activity definition “Catalysis of the reaction: ADP + H2O = IDP + NH3.”
- database_cross_reference “MetaCyc:ADP-DEAMINASE-RXN”
- database_cross_reference “EC:3.5.4.7”

Added

ADP deaminase activity definition “Catalysis of the reaction: ADP + H2O + H+ = IDP + NH4+.”
- database_cross_reference “RHEA:12741”

ADP metabolic process `http://purl.obolibrary.org/obo/GO_0046031`

Removed

ADP metabolic process definition “The chemical reactions and pathways involving ADP, adenosine 5’-diphosphate.”
- database_cross_reference “GOC:go_curators”

Added

ADP metabolic process definition “The chemical reactions and pathways involving ADP, adenosine 5’-diphosphate.”
- database_cross_reference “GOC:curators”

ADP-heptose-lipopolysaccharide heptosyltransferase activity `http://purl.obolibrary.org/obo/GO_0008713`

Added

ADP-riboxanase activity `http://purl.obolibrary.org/obo/GO_0140740`

Removed

ADP-riboxanase activity definition “Catalysis of the reaction: L-arginyl-[protein] + NAD+ = ADP-riboxanated L-argininyl-[protein] + H+ + NH4(+) + nicotinamide.”
- database_cross_reference “RHEA:69500”
- database_cross_reference “PMID:34671164”

Added

ADP-riboxanase activity database_cross_reference “Reactome:R-HSA-9956624”
- label “OspC3 ADP-riboxanates CASP4”
ADP-riboxanase activity definition “Catalysis of the reaction: L-arginyl-[protein] + NAD+ = ADP-riboxanated L-argininyl-[protein] + H+ + NH4+ + nicotinamide.”
- database_cross_reference “RHEA:69500”
- database_cross_reference “PMID:34671164”

AMP binding `http://purl.obolibrary.org/obo/GO_0016208`

Removed

AMP binding definition “Binding to AMP, adenosine monophosphate.”
- database_cross_reference “GOC:go_curators”

Added

AMP binding database_cross_reference “Reactome:R-HSA-453356”
- label “PYGB dimer, b form + 2 AMP => PYGB b dimer:AMP complex”
AMP binding database_cross_reference “Reactome:R-HSA-453342”
- label “PYGM dimer, b form + 2 AMP => PYGM b dimer:AMP complex”
AMP binding definition “Binding to AMP, adenosine monophosphate.”
- database_cross_reference “GOC:curators”

AMP biosynthetic process `http://purl.obolibrary.org/obo/GO_0006167`

Removed

AMP biosynthetic process definition “The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

AMP biosynthetic process definition “The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

AMP deaminase activity `http://purl.obolibrary.org/obo/GO_0003876`

Removed

AMP deaminase activity definition “Catalysis of the reaction: AMP + H2O = IMP + NH3.”
- database_cross_reference “EC:3.5.4.6”

Added

AMP deaminase activity definition “Catalysis of the reaction: AMP + H2O = IMP + NH4+.”
- database_cross_reference “RHEA:14777”

AMP metabolic process `http://purl.obolibrary.org/obo/GO_0046033`

Removed

AMP metabolic process definition “The chemical reactions and pathways involving AMP, adenosine monophosphate.”
- database_cross_reference “GOC:go_curators”

Added

AMP metabolic process definition “The chemical reactions and pathways involving AMP, adenosine monophosphate.”
- database_cross_reference “GOC:curators”

ATP biosynthetic process `http://purl.obolibrary.org/obo/GO_0006754`

Removed

ATP biosynthetic process definition “The chemical reactions and pathways resulting in the formation of ATP, adenosine 5’-triphosphate, a universally important coenzyme and enzyme regulator.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

ATP biosynthetic process definition “The chemical reactions and pathways resulting in the formation of ATP, adenosine 5’-triphosphate, a universally important coenzyme and enzyme regulator.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

ATP citrate synthase activity `http://purl.obolibrary.org/obo/GO_0003878`

Removed

ATP citrate synthase activity relatedMatch PWY-5172

Added

ATP citrate synthase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI

ATP deaminase activity `http://purl.obolibrary.org/obo/GO_0047692`

Removed

ATP deaminase activity definition “Catalysis of the reaction: ATP + H2O = ITP + NH3.”
- database_cross_reference “MetaCyc:ATP-DEAMINASE-RXN”
- database_cross_reference “EC:3.5.4.18”
ATP deaminase activity exactMatch 13037
ATP deaminase activity database_cross_reference “RHEA:13037”

Added

ATP deaminase activity definition “Catalysis of the reaction: ATP + H2O + H+ = ITP + NH4+.”
- database_cross_reference “RHEA:13037”
ATP deaminase activity broadMatch 13037

ATP hydrolysis activity `http://purl.obolibrary.org/obo/GO_0016887`

Added

ATP hydrolysis activity database_cross_reference “Reactome:R-HSA-9955731”
- label “ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide”
ATP hydrolysis activity database_cross_reference “Reactome:R-HSA-9948300”
- label “RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide”
ATP hydrolysis activity database_cross_reference “Reactome:R-HSA-9949632”
- label “VCP hexamer extracts K48 polyubiquitinated alanine-tailed nascent peptide from VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:K48polyUb-nascent peptide”

ATP metabolic process `http://purl.obolibrary.org/obo/GO_0046034`

Removed

ATP metabolic process definition “The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.”
- database_cross_reference “GOC:go_curators”

Added

ATP metabolic process definition “The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.”
- database_cross_reference “GOC:curators”

ATP-dependent diacylglycerol kinase activity `http://purl.obolibrary.org/obo/GO_0004143`

Added

ATP-dependent diacylglycerol kinase activity database_cross_reference “RHEA:43416”
ATP-dependent diacylglycerol kinase activity database_cross_reference “RHEA:40323”
ATP-dependent diacylglycerol kinase activity database_cross_reference “RHEA:43428”
ATP-dependent diacylglycerol kinase activity narrowMatch 40335
ATP-dependent diacylglycerol kinase activity narrowMatch 40323
ATP-dependent diacylglycerol kinase activity database_cross_reference “RHEA:40327”
ATP-dependent diacylglycerol kinase activity database_cross_reference “RHEA:43424”
ATP-dependent diacylglycerol kinase activity narrowMatch 43424
ATP-dependent diacylglycerol kinase activity narrowMatch 43428
ATP-dependent diacylglycerol kinase activity narrowMatch 40327
ATP-dependent diacylglycerol kinase activity narrowMatch 63324
ATP-dependent diacylglycerol kinase activity database_cross_reference “RHEA:40335”
ATP-dependent diacylglycerol kinase activity narrowMatch 43416
ATP-dependent diacylglycerol kinase activity database_cross_reference “RHEA:63324”
ATP-dependent diacylglycerol kinase activity narrowMatch 40359
ATP-dependent diacylglycerol kinase activity database_cross_reference “RHEA:40359”

ATPase activator activity `http://purl.obolibrary.org/obo/GO_0001671`

Removed

ATPase activator activity SubClassOf ATPase regulator activity

ATPase inhibitor activity `http://purl.obolibrary.org/obo/GO_0042030`

Removed

ATPase inhibitor activity SubClassOf ATPase regulator activity

ATPase regulator activity `http://purl.obolibrary.org/obo/GO_0060590`

Removed

ATPase regulator activity SubClassOf regulates some ATP-dependent activity
ATPase regulator activity SubClassOf molecular function regulator activity

Added

ATPase regulator activity term tracker item “https://github.com/geneontology/go-ontology/issues/31398”^^anyURI
ATPase regulator activity SubClassOf regulates some ATP hydrolysis activity
ATPase regulator activity SubClassOf nucleoside-triphosphatase regulator activity

ATPase-coupled intramembrane lipid carrier activity `http://purl.obolibrary.org/obo/GO_0140326`

Removed

ATPase-coupled intramembrane lipid carrier activity label “ATPase-coupled intramembrane lipid transporter activity”

Added

ATPase-coupled intramembrane lipid carrier activity label “ATPase-coupled intramembrane lipid carrier activity”
ATPase-coupled intramembrane lipid carrier activity has_broad_synonym “ATPase-coupled intramembrane lipid transporter activity”

ATPase-coupled polar amino acid-transporter activity `http://purl.obolibrary.org/obo/GO_0015426`

Added

ATPase-coupled transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0042626`

Added

ATPase-coupled transmembrane transporter activity database_cross_reference “Reactome:R-HSA-5690340”
- label “Defective ABCC6 does not transport organic anion from cytosol to extracellular region”
ATPase-coupled transmembrane transporter activity database_cross_reference “Reactome:R-HSA-1454916”
- label “The ABCC family mediates organic anion transport”

Bam protein complex `http://purl.obolibrary.org/obo/GO_1990063`

Added

Bam protein complex term tracker item “https://github.com/geneontology/go-ontology/issues/31720”^^anyURI
Bam protein complex SubClassOf extracellular protein-containing complex

C-4 methylsterol oxidase activity `http://purl.obolibrary.org/obo/GO_0000254`

Added

C-4 methylsterol oxidase activity database_cross_reference “Reactome:R-HSA-9947207”
- label “MSMO1 oxidizes 4a-me-5a-cholest-8-en-3b-ol to 4a-carboxy-5a-cholest-8-ene-3b-ol”
C-4 methylsterol oxidase activity database_cross_reference “Reactome:R-HSA-9947203”
- label “MSMO1 oxidizes 4,4-diMe-5-cholest-8-en-3-ol to 4a-carboxy-4b-me-5a-cholest-8-en-3b-ol”

CAAX-protein geranylgeranyltransferase activity `http://purl.obolibrary.org/obo/GO_0004662`

Added

CAAX-protein geranylgeranyltransferase activity database_cross_reference “Reactome:R-HSA-9954195”
- label “FNTA:PGGT1B geranylgeranylates GBP5”
CAAX-protein geranylgeranyltransferase activity database_cross_reference “Reactome:R-HSA-9947999”
- label “FNTA:PGGT1B geranylgeranylates GBP2”

CENP-A containing nucleosome `http://purl.obolibrary.org/obo/GO_0043505`

Removed

CENP-A containing nucleosome definition “A form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3).”
- database_cross_reference “PMID:16183641”
- database_cross_reference “PMID:15175412”
- database_cross_reference “GOC:go_curators”

Added

CENP-A containing nucleosome definition “A form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3).”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:16183641”
- database_cross_reference “PMID:15175412”

CMP metabolic process `http://purl.obolibrary.org/obo/GO_0046035`

Removed

CMP metabolic process definition “The chemical reactions and pathways involving CMP, cytidine monophosphate.”
- database_cross_reference “GOC:go_curators”

Added

CMP metabolic process definition “The chemical reactions and pathways involving CMP, cytidine monophosphate.”
- database_cross_reference “GOC:curators”

CNTFR-CLCF1 complex `http://purl.obolibrary.org/obo/GO_0097059`

Removed

CNTFR-CLCF1 complex SubClassOf part of some extracellular region
CNTFR-CLCF1 complex SubClassOf protein-containing complex

Added

CNTFR-CLCF1 complex SubClassOf extracellular protein-containing complex

CO-methylating acetyl-CoA synthase activity `http://purl.obolibrary.org/obo/GO_0043884`

Removed

CO-methylating acetyl-CoA synthase activity definition “Catalysis of the reaction: acetyl-CoA + corrinoid protein = CO + methylcorrinoid protein + CoA.”
- database_cross_reference “PMID:1748656”
- database_cross_reference “EC:2.3.1.169”

Added

CO-methylating acetyl-CoA synthase activity definition “Catalysis of the reaction: Co(I)-[corrinoid Fe-S protein] + acetyl-CoA + H+ = methyl-Co(III)-[corrinoid Fe-S protein] + CO + CoA.”
- database_cross_reference “PMID:1748656”
- database_cross_reference “RHEA:45212”

COG complex `http://purl.obolibrary.org/obo/GO_0017119`

Removed

COG complex has_exact_synonym “COG complex”
COG complex label “Golgi transport complex”

Added

COG complex term tracker item “https://github.com/geneontology/go-ontology/issues/31397”^^anyURI
COG complex has_exact_synonym “Golgi transport complex”
COG complex label “COG complex”

COG complex binding `http://purl.obolibrary.org/obo/GO_0140164`

Removed

COG complex binding label “Golgi transport complex binding”
COG complex binding has_exact_synonym “COG complex binding”

Added

COG complex binding term tracker item “https://github.com/geneontology/go-ontology/issues/31397”^^anyURI
COG complex binding label “COG complex binding”
COG complex binding has_exact_synonym “Golgi transport complex binding”

CRLF-CLCF1 complex `http://purl.obolibrary.org/obo/GO_0097058`

Removed

CRLF-CLCF1 complex SubClassOf part of some extracellular region
CRLF-CLCF1 complex SubClassOf protein-containing complex

Added

CRLF-CLCF1 complex SubClassOf extracellular protein-containing complex

CTP metabolic process `http://purl.obolibrary.org/obo/GO_0046036`

Removed

CTP metabolic process definition “The chemical reactions and pathways involving CTP, cytidine triphosphate.”
- database_cross_reference “GOC:go_curators”

Added

CTP metabolic process definition “The chemical reactions and pathways involving CTP, cytidine triphosphate.”
- database_cross_reference “GOC:curators”

CoA-dependent peptidyl-lysine N6-myristoyltransferase activity `http://purl.obolibrary.org/obo/GO_0140770`

Added

CoA-ligase activity `http://purl.obolibrary.org/obo/GO_0016405`

Removed

CoA-ligase activity database_cross_reference “Reactome:R-HSA-6798345”
- label “PXLP-GCAT dimer ligates CoASH to 2A-3OB to form Gly and Ac-CoA”
CoA-ligase activity SubClassOf ligase activity, forming carbon-sulfur bonds

Added

CoA-ligase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31616”^^anyURI
CoA-ligase activity SubClassOf acid-thiol ligase activity

D-4-hydroxyphenylglycine:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0047320`

Removed

D-4-hydroxyphenylglycine:2-oxoglutarate transaminase activity label “D-4-hydroxyphenylglycine transaminase activity”
D-4-hydroxyphenylglycine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + D-4-hydroxyphenylglycine = 4-hydroxyphenylglyoxylate + L-glutamate.”
- database_cross_reference “RHEA:15589”
- database_cross_reference “EC:2.6.1.72”

Added

D-4-hydroxyphenylglycine:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
D-4-hydroxyphenylglycine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + D-4-hydroxyphenylglycine = 4-hydroxyphenylglyoxylate + L-glutamate.”
- database_cross_reference “RHEA:15589”
D-4-hydroxyphenylglycine:2-oxoglutarate transaminase activity has_exact_synonym “D-4-hydroxyphenylglycine transaminase activity”
D-4-hydroxyphenylglycine:2-oxoglutarate transaminase activity label “D-4-hydroxyphenylglycine:2-oxoglutarate transaminase activity”

D-alanine [D-alanyl carrier protein] ligase activity `http://purl.obolibrary.org/obo/GO_0047473`

Removed

D-alanine [D-alanyl carrier protein] ligase activity definition “Catalysis of the ATP-dependent activation of D-alanine and its transfer as a thiol ester to the phosphopantheinyl prosthetic group of a D-alanyl carrier protein, according to the reaction: ATP + D-alanine + a [D-alaninyl carrier protein] = a D-alanyl-[D-alanyl carrier protein] + AMP + diphosphate.”
- database_cross_reference “GOC:pg”

Added

D-alanine [D-alanyl carrier protein] ligase activity database_cross_reference “RHEA:55132”
D-alanine [D-alanyl carrier protein] ligase activity database_cross_reference “EC:6.2.1.54”
D-alanine [D-alanyl carrier protein] ligase activity definition “Catalysis of the ATP-dependent activation of D-alanine and its transfer as a thiol ester to the phosphopantheinyl prosthetic group of a D-alanyl carrier protein, according to the reaction: holo-[D-alanyl-carrier protein] + D-alanine + ATP = D-alanyl-[D-alanyl-carrier protein] + AMP + diphosphate.”
- database_cross_reference “RHEA:55132”

D-alanine biosynthetic process `http://purl.obolibrary.org/obo/GO_0030632`

Removed

D-alanine biosynthetic process SubClassOf obsolete D-alanine metabolic process

D-alanine catabolic process `http://purl.obolibrary.org/obo/GO_0055130`

Removed

D-alanine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of D-alanine, the D-enantiomer of the amino acid alanine.”
- database_cross_reference “GOC:ecd”
D-alanine catabolic process SubClassOf obsolete D-alanine metabolic process

Added

D-alanine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of D-alanine.”
- database_cross_reference “GOC:curators”
D-alanine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31357”^^anyURI
D-alanine catabolic process database_cross_reference “MetaCyc:PWY-8448”
D-alanine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI

D-alanine:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0047810`

Removed

D-alanine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: D-alanine + 2-oxoglutarate = pyruvate + D-glutamate.”
- database_cross_reference “EC:2.6.1.21”
D-alanine:2-oxoglutarate transaminase activity label “D-alanine-2-oxoglutarate aminotransferase activity”
D-alanine:2-oxoglutarate transaminase activity SubClassOf transaminase activity

Added

D-alanine:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
D-alanine:2-oxoglutarate transaminase activity label “D-alanine:2-oxoglutarate transaminase activity”
D-alanine:2-oxoglutarate transaminase activity has_exact_synonym “D-alanine-2-oxoglutarate aminotransferase activity”
D-alanine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: D-alanine + 2-oxoglutarate = pyruvate + D-glutamate.”
- database_cross_reference “RHEA:15869”
D-alanine:2-oxoglutarate transaminase activity SubClassOf amino acid transaminase activity

D-amino-acid N-acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0047812`

Removed

D-amino-acid N-acetyltransferase activity SubClassOf N-acetyltransferase activity

Added

D-amino-acid N-acetyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31474”^^anyURI
D-amino-acid N-acetyltransferase activity SubClassOf amino acid acyltransferase activity

D-amino-acid dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0008718`

Removed

D-amino-acid dehydrogenase activity definition “Catalysis of the reaction: a D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor.”
- database_cross_reference “RHEA:18125”

Added

D-amino-acid dehydrogenase activity narrowMatch 43572
D-amino-acid dehydrogenase activity definition “Catalysis of the reaction: a D-alpha-amino acid + a quinone + H2O = a 2-oxocarboxylate + a quinol + NH4+.”
- database_cross_reference “RHEA:18125”
D-amino-acid dehydrogenase activity narrowMatch 37219
D-amino-acid dehydrogenase activity database_cross_reference “RHEA:37255”
D-amino-acid dehydrogenase activity database_cross_reference “RHEA:37219”
D-amino-acid dehydrogenase activity database_cross_reference “RHEA:45996”
D-amino-acid dehydrogenase activity narrowMatch 37255
D-amino-acid dehydrogenase activity database_cross_reference “RHEA:43572”
D-amino-acid dehydrogenase activity narrowMatch 55948
D-amino-acid dehydrogenase activity database_cross_reference “RHEA:55948”
D-amino-acid dehydrogenase activity narrowMatch 45996

D-amino-acid oxidase activity `http://purl.obolibrary.org/obo/GO_0003884`

Added

D-amino-acid oxidase activity narrowMatch 78227
D-amino-acid oxidase activity narrowMatch 78247
D-amino-acid oxidase activity database_cross_reference “RHEA:78247”
D-amino-acid oxidase activity narrowMatch 70959
D-amino-acid oxidase activity narrowMatch 78223
D-amino-acid oxidase activity narrowMatch 78243
D-amino-acid oxidase activity narrowMatch 78239
D-amino-acid oxidase activity database_cross_reference “RHEA:70963”
D-amino-acid oxidase activity database_cross_reference “RHEA:70971”
D-amino-acid oxidase activity database_cross_reference “RHEA:78235”
D-amino-acid oxidase activity database_cross_reference “RHEA:78219”
D-amino-acid oxidase activity narrowMatch 70951
D-amino-acid oxidase activity narrowMatch 70971
D-amino-acid oxidase activity narrowMatch 37583
D-amino-acid oxidase activity database_cross_reference “RHEA:78203”
D-amino-acid oxidase activity database_cross_reference “RHEA:78223”
D-amino-acid oxidase activity database_cross_reference “RHEA:70951”
D-amino-acid oxidase activity database_cross_reference “RHEA:78215”
D-amino-acid oxidase activity database_cross_reference “RHEA:78251”
D-amino-acid oxidase activity database_cross_reference “RHEA:78227”
D-amino-acid oxidase activity database_cross_reference “RHEA:37583”
D-amino-acid oxidase activity narrowMatch 78215
D-amino-acid oxidase activity database_cross_reference “RHEA:78211”
D-amino-acid oxidase activity database_cross_reference “RHEA:78207”
D-amino-acid oxidase activity narrowMatch 78235
D-amino-acid oxidase activity database_cross_reference “RHEA:78255”
D-amino-acid oxidase activity narrowMatch 70963
D-amino-acid oxidase activity database_cross_reference “RHEA:78243”
D-amino-acid oxidase activity narrowMatch 78203
D-amino-acid oxidase activity database_cross_reference “RHEA:70959”
D-amino-acid oxidase activity narrowMatch 78207
D-amino-acid oxidase activity narrowMatch 78791
D-amino-acid oxidase activity narrowMatch 78255
D-amino-acid oxidase activity narrowMatch 78251
D-amino-acid oxidase activity narrowMatch 78219
D-amino-acid oxidase activity narrowMatch 78211
D-amino-acid oxidase activity database_cross_reference “RHEA:78791”
D-amino-acid oxidase activity database_cross_reference “RHEA:78239”

D-aminoacyl-tRNA deacylase activity `http://purl.obolibrary.org/obo/GO_0051499`

Added

D-aminoacyl-tRNA deacylase activity database_cross_reference “RHEA:69795”
D-aminoacyl-tRNA deacylase activity database_cross_reference “RHEA:69791”
D-aminoacyl-tRNA deacylase activity database_cross_reference “RHEA:69799”
D-aminoacyl-tRNA deacylase activity narrowMatch 69791
D-aminoacyl-tRNA deacylase activity narrowMatch 69799
D-aminoacyl-tRNA deacylase activity narrowMatch 69795

D-arabinose catabolic process to D-xylulose 5-phosphate `http://purl.obolibrary.org/obo/GO_0019573`

Removed

D-arabinose catabolic process to D-xylulose 5-phosphate definition “The chemical reactions and pathways resulting in the breakdown of D-arabinose to form D-xylulose 5-phosphate. D-arabinose is converted into D-ribulose, which is phosphorylated to D-ribulose-5-phosphate, which is isomerized to give D-xylulose-5-phosphate.”
- database_cross_reference “GOC:go_curators”

Added

D-arabinose catabolic process to D-xylulose 5-phosphate definition “The chemical reactions and pathways resulting in the breakdown of D-arabinose to form D-xylulose 5-phosphate. D-arabinose is converted into D-ribulose, which is phosphorylated to D-ribulose-5-phosphate, which is isomerized to give D-xylulose-5-phosphate.”
- database_cross_reference “GOC:curators”

D-cysteine desulfhydrase activity `http://purl.obolibrary.org/obo/GO_0019148`

Removed

D-cysteine desulfhydrase activity definition “Catalysis of the reaction: D-cysteine + H2O = sulfide + NH3 + pyruvate.”
- database_cross_reference “EC:4.4.1.15”

Added

D-cysteine desulfhydrase activity definition “Catalysis of the reaction: D-cysteine + H2O = hydrogen sulfide + pyruvate + NH4+ + H+.”
- database_cross_reference “RHEA:11268”

D-galactarate biosynthetic process `http://purl.obolibrary.org/obo/GO_0046357`

Removed

D-galactarate biosynthetic process has_related_synonym “D-galactarate synthesis”
D-galactarate biosynthetic process has_related_synonym “D-galactarate biosynthesis”
D-galactarate biosynthetic process label “galactarate biosynthetic process”
D-galactarate biosynthetic process has_related_synonym “D-galactarate biosynthetic process”

Added

D-galactarate biosynthetic process label “D-galactarate biosynthetic process”
D-galactarate biosynthetic process has_exact_synonym “D-galactarate biosynthesis”
D-galactarate biosynthetic process has_exact_synonym “D-galactarate synthesis”
D-galactarate biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/27059”^^anyURI
D-galactarate biosynthetic process SubClassOf carbohydrate biosynthetic process

D-galactarate catabolic process `http://purl.obolibrary.org/obo/GO_0046392`

Removed

D-galactarate catabolic process has_related_synonym “D-galactarate catabolic process”
D-galactarate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of galactarate, the anion of galactaric acid.”
- database_cross_reference “GOC:ai”
- database_cross_reference “GOC:pr”
D-galactarate catabolic process label “galactarate catabolic process”

Added

D-galactarate catabolic process database_cross_reference “MetaCyc:PWY-6497”
D-galactarate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
D-galactarate catabolic process narrowMatch PWY-6497
D-galactarate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/27059”^^anyURI
D-galactarate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of D-galactarate, the anion of galactaric acid.”
- database_cross_reference “GOC:ai”
- database_cross_reference “GOC:pr”
D-galactarate catabolic process label “D-galactarate catabolic process”
D-galactarate catabolic process narrowMatch GALACTARDEG-PWY
D-galactarate catabolic process SubClassOf carbohydrate catabolic process

D-galactonate:proton symporter activity `http://purl.obolibrary.org/obo/GO_0042881`

Removed

D-galactonate:proton symporter activity label “D-galactonate transmembrane transporter activity”
D-galactonate:proton symporter activity definition “Enables the transfer of D-galactonate, the D-enantiomer of galactonate, from one side of a membrane to the other.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:jl”
- database_cross_reference “ISBN:0815340729”
- database_cross_reference “GOC:mtg_transport”
- database_cross_reference “GOC:jsg”
- database_cross_reference “ISBN:0198506732”
D-galactonate:proton symporter activity SubClassOf monocarboxylic acid transmembrane transporter activity
D-galactonate:proton symporter activity SubClassOf carbohydrate transmembrane transporter activity

Added

D-galactonate:proton symporter activity exactMatch 29835
D-galactonate:proton symporter activity label “D-galactonate:proton symporter activity”
D-galactonate:proton symporter activity definition “Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-galactonate(out) + H+(out) = D-galactonate(in) + H+(in).”
- database_cross_reference “RHEA:29835”
D-galactonate:proton symporter activity has_broad_synonym “D-galactonate transmembrane transporter activity”
D-galactonate:proton symporter activity database_cross_reference “RHEA:29835”
D-galactonate:proton symporter activity SubClassOf carbohydrate:proton symporter activity
D-galactonate:proton symporter activity SubClassOf secondary active monocarboxylate transmembrane transporter activity

D-galacturonate catabolic process `http://purl.obolibrary.org/obo/GO_0019698`

Added

D-galacturonate catabolic process database_cross_reference “MetaCyc:PWY-8391”
D-galacturonate catabolic process narrowMatch PWY-6486
D-galacturonate catabolic process database_cross_reference “MetaCyc:PWY-6491”
D-galacturonate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
D-galacturonate catabolic process narrowMatch GALACTUROCAT-PWY
D-galacturonate catabolic process narrowMatch PWY-8391
D-galacturonate catabolic process database_cross_reference “MetaCyc:PWY-6486”
D-galacturonate catabolic process narrowMatch PWY-6491

D-glucarate catabolic process `http://purl.obolibrary.org/obo/GO_0042838`

Removed

D-glucarate catabolic process SubClassOf obsolete glucarate catabolic process

Added

D-glucarate catabolic process database_cross_reference “MetaCyc:GLUCARDEG-PWY”
D-glucarate catabolic process database_cross_reference “MetaCyc:PWY-6499”
D-glucarate catabolic process narrowMatch GLUCARDEG-PWY
D-glucarate catabolic process narrowMatch PWY-6499
D-glucarate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
D-glucarate catabolic process SubClassOf aldaric acid catabolic process

D-glucose transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0055056`

Added

D-glucose transmembrane transporter activity database_cross_reference “Reactome:R-HSA-5653873”
- label “SLC2A1 tetramer transports Glc from cytosol to Golgi lumen”
D-glucose transmembrane transporter activity database_cross_reference “Reactome:R-HSA-499981”
- label “Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2”

D-glucuronate catabolic process to D-xylulose 5-phosphate `http://purl.obolibrary.org/obo/GO_0019640`

Removed

D-glucuronate catabolic process to D-xylulose 5-phosphate definition “The chemical reactions and pathways resulting in the breakdown of D-glucuronate into D-xylulose 5-phosphate.”
- database_cross_reference “PMID:27189775”
- database_cross_reference “GOC:go_curators”

Added

D-glucuronate catabolic process to D-xylulose 5-phosphate definition “The chemical reactions and pathways resulting in the breakdown of D-glucuronate into D-xylulose 5-phosphate.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:27189775”

D-glutaminase activity `http://purl.obolibrary.org/obo/GO_0050001`

Removed

D-glutaminase activity definition “Catalysis of the reaction: H2O + L-glutamine = NH3 + D-glutamate.”
- database_cross_reference “EC:3.5.1.35”
- database_cross_reference “MetaCyc:D-GLUTAMINASE-RXN”

Added

D-glutaminase activity definition “Catalysis of the reaction: D-glutamine + H2O = D-glutamate + NH4+.”
- database_cross_reference “RHEA:22840”

D-lactate dehydrogenase (quinone) activity `http://purl.obolibrary.org/obo/GO_0102029`

Added

D-lactate dehydrogenase (quinone) activity database_cross_reference “RHEA:29079”
D-lactate dehydrogenase (quinone) activity narrowMatch 29079

D-lactate dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0047809`

Added

D-lactate dehydrogenase activity database_cross_reference “RHEA:62968”
D-lactate dehydrogenase activity narrowMatch 62968

D-lysine:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0043911`

Removed

D-lysine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: D-lysine + 2-oxoglutarate = L-glutamate + 6-amino-2-oxohexanoate.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:17259313”
D-lysine:2-oxoglutarate transaminase activity label “D-lysine transaminase activity”
D-lysine:2-oxoglutarate transaminase activity SubClassOf transaminase activity

Added

D-lysine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: D-lysine + 2-oxoglutarate = 6-amino-2-oxohexanoate + L-glutamate.”
- database_cross_reference “RHEA:37587”
- database_cross_reference “PMID:17259313”
D-lysine:2-oxoglutarate transaminase activity database_cross_reference “RHEA:37587”
D-lysine:2-oxoglutarate transaminase activity has_broad_synonym “D-lysine transaminase activity”
D-lysine:2-oxoglutarate transaminase activity exactMatch 37587
D-lysine:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
D-lysine:2-oxoglutarate transaminase activity label “D-lysine:2-oxoglutarate transaminase activity”
D-lysine:2-oxoglutarate transaminase activity SubClassOf amino acid transaminase activity

D-methionine:pyruvate transaminase activity `http://purl.obolibrary.org/obo/GO_0047306`

Removed

D-methionine:pyruvate transaminase activity label “D-methionine-pyruvate transaminase activity”
D-methionine:pyruvate transaminase activity definition “Catalysis of the reaction: D-methionine + pyruvate = 4-methylthio-2-oxobutanoate + L-alanine.”
- database_cross_reference “EC:2.6.1.41”
- database_cross_reference “RHEA:23836”
D-methionine:pyruvate transaminase activity SubClassOf transaminase activity

Added

D-methionine:pyruvate transaminase activity has_exact_synonym “D-methionine-pyruvate transaminase activity”
D-methionine:pyruvate transaminase activity label “D-methionine:pyruvate transaminase activity”
D-methionine:pyruvate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
D-methionine:pyruvate transaminase activity definition “Catalysis of the reaction: D-methionine + pyruvate = 4-methylthio-2-oxobutanoate + L-alanine.”
- database_cross_reference “RHEA:23836”
D-methionine:pyruvate transaminase activity SubClassOf amino acid transaminase activity

D-ribitol-5-phosphate cytidylyltransferase activity `http://purl.obolibrary.org/obo/GO_0047349`

Added

D-ribitol-5-phosphate cytidylyltransferase activity database_cross_reference “Reactome:R-HSA-9940844”
- label “CRPPA dimer transfers cytidylyl to Rbt5P”

D-ribulose-phosphate 3-epimerase activity `http://purl.obolibrary.org/obo/GO_0004750`

Removed

D-ribulose-phosphate 3-epimerase activity database_cross_reference “Reactome:R-HSA-199803”
- label “xylulose 5-phosphate <=> D-ribulose 5-phosphate”

Added

D-ribulose-phosphate 3-epimerase activity database_cross_reference “Reactome:R-HSA-199803”
- label “RPE dimers isomerize XY5P to RU5P”

D-serine ammonia-lyase activity `http://purl.obolibrary.org/obo/GO_0008721`

Removed

D-serine ammonia-lyase activity definition “Catalysis of the reaction: D-serine = pyruvate + NH3.”
- database_cross_reference “EC:4.3.1.18”

Added

D-serine ammonia-lyase activity definition “Catalysis of the reaction: D-serine = pyruvate + NH4+.”
- database_cross_reference “RHEA:13977”

D-serine biosynthetic process `http://purl.obolibrary.org/obo/GO_0070179`

Removed

D-serine biosynthetic process SubClassOf obsolete D-serine metabolic process

D-serine catabolic process `http://purl.obolibrary.org/obo/GO_0036088`

Removed

D-serine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of D-serine, the D-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.”
- database_cross_reference “GOC:imk”
D-serine catabolic process SubClassOf obsolete D-serine metabolic process

Added

D-serine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31357”^^anyURI
D-serine catabolic process database_cross_reference “MetaCyc:PWY0-1535”
D-serine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI
D-serine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of D-serine.”
- database_cross_reference “GOC:curators”

D-sorbitol biosynthetic process `http://purl.obolibrary.org/obo/GO_0006061`

Removed

D-sorbitol biosynthetic process label “sorbitol biosynthetic process”

Added

D-sorbitol biosynthetic process database_cross_reference “MetaCyc:PWY-5054”
D-sorbitol biosynthetic process narrowMatch PWY-5054
D-sorbitol biosynthetic process database_cross_reference “MetaCyc:PWY-5530”
D-sorbitol biosynthetic process narrowMatch PWY-5530
D-sorbitol biosynthetic process label “D-sorbitol biosynthetic process”

D-sorbitol catabolic process `http://purl.obolibrary.org/obo/GO_0006062`

Removed

D-sorbitol catabolic process label “sorbitol catabolic process”

Added

D-sorbitol catabolic process database_cross_reference “MetaCyc:PWY-4101”
D-sorbitol catabolic process label “D-sorbitol catabolic process”
D-sorbitol catabolic process narrowMatch SORBDEG-PWY
D-sorbitol catabolic process narrowMatch PWY-4101
D-sorbitol catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI

D-sorbitol metabolic process `http://purl.obolibrary.org/obo/GO_0006060`

Removed

D-sorbitol metabolic process label “sorbitol metabolic process”
D-sorbitol metabolic process database_cross_reference “MetaCyc:P461-PWY”

Added

D-sorbitol metabolic process label “D-sorbitol metabolic process”

D-threo-aldose 1-dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0047834`

Added

D-threo-aldose 1-dehydrogenase activity database_cross_reference “RHEA:81515”
D-threo-aldose 1-dehydrogenase activity narrowMatch 81519
D-threo-aldose 1-dehydrogenase activity database_cross_reference “RHEA:81519”
D-threo-aldose 1-dehydrogenase activity narrowMatch 81515
D-threo-aldose 1-dehydrogenase activity database_cross_reference “RHEA:81523”
D-threo-aldose 1-dehydrogenase activity narrowMatch 81523

D-tryptophan N-malonyltransferase activity `http://purl.obolibrary.org/obo/GO_0047836`

Added

D-tryptophan N-malonyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31474”^^anyURI
D-tryptophan N-malonyltransferase activity SubClassOf amino acid acyltransferase activity

D-xylose catabolic process `http://purl.obolibrary.org/obo/GO_0042843`

Added

D-xylose catabolic process narrowMatch PWY-6760
D-xylose catabolic process database_cross_reference “MetaCyc:PWY-6760”
D-xylose catabolic process database_cross_reference “MetaCyc:PWY-8020”
D-xylose catabolic process narrowMatch PWY-8330
D-xylose catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
D-xylose catabolic process narrowMatch PWY-8020
D-xylose catabolic process database_cross_reference “MetaCyc:PWY-8330”
D-xylose catabolic process database_cross_reference “MetaCyc:PWY-7294”
D-xylose catabolic process database_cross_reference “MetaCyc:PWY-5516”
D-xylose catabolic process database_cross_reference “MetaCyc:XYLCAT-PWY”
D-xylose catabolic process narrowMatch PWY-5516
D-xylose catabolic process narrowMatch PWY-7294
D-xylose catabolic process narrowMatch XYLCAT-PWY

DNA catabolic process `http://purl.obolibrary.org/obo/GO_0006308`

Removed

DNA catabolic process definition “The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3’-phosphate group of each constituent deoxyribonucleotide being joined in 3’,5’-phosphodiester linkage to the 5’-hydroxyl group of the deoxyribose moiety of the next one.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

DNA catabolic process definition “The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3’-phosphate group of each constituent deoxyribonucleotide being joined in 3’,5’-phosphodiester linkage to the 5’-hydroxyl group of the deoxyribose moiety of the next one.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

DNA damage response `http://purl.obolibrary.org/obo/GO_0006974`

Removed

DNA damage response definition “Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.”
- database_cross_reference “GOC:go_curators”

Added

DNA damage response definition “Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.”
- database_cross_reference “GOC:curators”

DNA damage response, signal transduction by p53 class mediator `http://purl.obolibrary.org/obo/GO_0030330`

Removed

DNA damage response, signal transduction by p53 class mediator definition “A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.”
- database_cross_reference “GOC:go_curators”

Added

DNA damage response, signal transduction by p53 class mediator database_cross_reference “Reactome:R-HSA-69563”
- label “p53-Dependent G1 DNA Damage Response”
DNA damage response, signal transduction by p53 class mediator database_cross_reference “Reactome:R-HSA-6791312”
- label “TP53 Regulates Transcription of Cell Cycle Genes”
DNA damage response, signal transduction by p53 class mediator definition “A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.”
- database_cross_reference “GOC:curators”

DNA damage response, signal transduction resulting in transcription `http://purl.obolibrary.org/obo/GO_0042772`

Removed

DNA damage response, signal transduction resulting in transcription definition “A cascade of processes initiated in response to the detection of DNA damage, and resulting in the induction of transcription.”
- database_cross_reference “GOC:go_curators”

Added

DNA damage response, signal transduction resulting in transcription definition “A cascade of processes initiated in response to the detection of DNA damage, and resulting in the induction of transcription.”
- database_cross_reference “GOC:curators”

DNA ligase (ATP) activity `http://purl.obolibrary.org/obo/GO_0003910`

Added

DNA ligase (ATP) activity database_cross_reference “Reactome:R-HSA-9914903”
- label “LIG3 (Ligase III) ligates nascent mitochondrial DNA strands”

DNA polymerase activity `http://purl.obolibrary.org/obo/GO_0034061`

Added

DNA polymerase activity narrowMatch 67728
DNA polymerase activity narrowMatch 86319
DNA polymerase activity database_cross_reference “RHEA:67728”
DNA polymerase activity database_cross_reference “RHEA:86319”

DNA synthesis involved in double-strand break repair via homologous recombination `http://purl.obolibrary.org/obo/GO_0043150`

Removed

DNA synthesis involved in double-strand break repair via homologous recombination definition “The synthesis of DNA that contributes to the process of double-strand break repair via homologous recombination.”
- database_cross_reference “GOC:go_curators”

Added

DNA synthesis involved in double-strand break repair via homologous recombination definition “The synthesis of DNA that contributes to the process of double-strand break repair via homologous recombination.”
- database_cross_reference “GOC:curators”

DNA topoisomerase type I (single strand cut, ATP-independent) activity `http://purl.obolibrary.org/obo/GO_0003917`

Added

DNA topoisomerase type I (single strand cut, ATP-independent) activity database_cross_reference “Reactome:R-HSA-9914922”
- label “TOP3A (Topoisomerase 3a) decatenates mitochondrial DNA”

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity `http://purl.obolibrary.org/obo/GO_0072586`

Removed

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity SubClassOf ATPase regulator activity

DNA-binding transcription activator activity, RNA polymerase II-specific `http://purl.obolibrary.org/obo/GO_0001228`

Added

DNA-binding transcription activator activity, RNA polymerase II-specific database_cross_reference “Reactome:R-HSA-8937177”
- label “AHR:TCDD binds ARNT”

DNA-binding transcription repressor activity, RNA polymerase II-specific `http://purl.obolibrary.org/obo/GO_0001227`

Added

DNA-binding transcription repressor activity, RNA polymerase II-specific database_cross_reference “Reactome:R-HSA-8936851”
- label “AHRR binds ARNT”

DNA-directed DNA polymerase activity `http://purl.obolibrary.org/obo/GO_0003887`

Added

DNA-directed DNA polymerase activity database_cross_reference “Reactome:R-HSA-9914498”
- label “POLG in the replisome polymerizes the L strand”
DNA-directed DNA polymerase activity database_cross_reference “Reactome:R-HSA-9914364”
- label “POLG in the replisome polymerizes the H strand”

DNA-directed RNA polymerase activity `http://purl.obolibrary.org/obo/GO_0003899`

Added

DNA-directed RNA polymerase activity database_cross_reference “Reactome:R-HSA-9914409”
- label “POLRMT polymerizes RNA primer for mitochondrial L strand replication”
DNA-directed RNA polymerase activity database_cross_reference “Reactome:R-HSA-6814549”
- label “Pre-snRNA transcript initiation, Integrator binding, LEC binding”
DNA-directed RNA polymerase activity database_cross_reference “Reactome:R-HSA-1964482”
- label “RNA polymerase III transcribes microbial dsDNA to dsRNA”
DNA-directed RNA polymerase activity database_cross_reference “Reactome:R-HSA-9915448”
- label “POLRMT polymerizes R-loop RNA”
DNA-directed RNA polymerase activity database_cross_reference “Reactome:R-HSA-6814559”
- label “Pre-snRNA is elongated and capped with 7-methylguanosine”

Delta14-sterol reductase activity `http://purl.obolibrary.org/obo/GO_0050613`

Added

Delta14-sterol reductase activity database_cross_reference “Reactome:R-HSA-9946140”
- label “TM7SF2 reduces 4,4-diMeCholesta-8,14-dien-3-ol to 4,4-diMe5-cholest-8-en-3-ol”

Delta4-3-oxosteroid 5beta-reductase activity `http://purl.obolibrary.org/obo/GO_0047787`

Added

Delta4-3-oxosteroid 5beta-reductase activity database_cross_reference “RHEA:46660”
Delta4-3-oxosteroid 5beta-reductase activity narrowMatch 46664
Delta4-3-oxosteroid 5beta-reductase activity narrowMatch 46632
Delta4-3-oxosteroid 5beta-reductase activity narrowMatch 46644
Delta4-3-oxosteroid 5beta-reductase activity narrowMatch 47080
Delta4-3-oxosteroid 5beta-reductase activity database_cross_reference “RHEA:46664”
Delta4-3-oxosteroid 5beta-reductase activity narrowMatch 46668
Delta4-3-oxosteroid 5beta-reductase activity narrowMatch 46656
Delta4-3-oxosteroid 5beta-reductase activity database_cross_reference “RHEA:46672”
Delta4-3-oxosteroid 5beta-reductase activity database_cross_reference “RHEA:46668”
Delta4-3-oxosteroid 5beta-reductase activity database_cross_reference “RHEA:46656”
Delta4-3-oxosteroid 5beta-reductase activity narrowMatch 46652
Delta4-3-oxosteroid 5beta-reductase activity narrowMatch 46636
Delta4-3-oxosteroid 5beta-reductase activity narrowMatch 14037
Delta4-3-oxosteroid 5beta-reductase activity database_cross_reference “RHEA:46632”
Delta4-3-oxosteroid 5beta-reductase activity narrowMatch 46640
Delta4-3-oxosteroid 5beta-reductase activity narrowMatch 46660
Delta4-3-oxosteroid 5beta-reductase activity database_cross_reference “RHEA:46636”
Delta4-3-oxosteroid 5beta-reductase activity database_cross_reference “RHEA:11524”
Delta4-3-oxosteroid 5beta-reductase activity narrowMatch 46672
Delta4-3-oxosteroid 5beta-reductase activity narrowMatch 11524
Delta4-3-oxosteroid 5beta-reductase activity database_cross_reference “RHEA:14037”
Delta4-3-oxosteroid 5beta-reductase activity database_cross_reference “RHEA:46640”
Delta4-3-oxosteroid 5beta-reductase activity database_cross_reference “RHEA:47080”
Delta4-3-oxosteroid 5beta-reductase activity database_cross_reference “RHEA:46652”
Delta4-3-oxosteroid 5beta-reductase activity database_cross_reference “RHEA:46644”

EMILIN complex `http://purl.obolibrary.org/obo/GO_1990971`

Added

EMILIN complex SubClassOf extracellular protein-containing complex

F-actin capping protein complex `http://purl.obolibrary.org/obo/GO_0008290`

Removed

F-actin capping protein complex definition “A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198599560”

Added

F-actin capping protein complex definition “A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198599560”

F-actin monooxygenase activity `http://purl.obolibrary.org/obo/GO_0120501`

Added

F-actin monooxygenase activity database_cross_reference “RHEA:24722”
F-actin monooxygenase activity database_cross_reference “RHEA:49676”
F-actin monooxygenase activity narrowMatch 24722
F-actin monooxygenase activity narrowMatch 49676

FACIT collagen trimer `http://purl.obolibrary.org/obo/GO_0005593`

Added

FACIT collagen trimer SubClassOf extracellular protein-containing complex

FAD binding `http://purl.obolibrary.org/obo/GO_0071949`

Added

FAD binding database_cross_reference “Reactome:R-HSA-9854672”
- label “FAD attaches to SDHA”

FAHFA hydrolase activity `http://purl.obolibrary.org/obo/GO_0120573`

Added

FAHFA hydrolase activity created by “sjm”
FAHFA hydrolase activity database_cross_reference “RHEA:52084”
FAHFA hydrolase activity has_obo_namespace “molecular_function”
FAHFA hydrolase activity narrowMatch 52072
FAHFA hydrolase activity narrowMatch 52080
FAHFA hydrolase activity database_cross_reference “RHEA:52064”
FAHFA hydrolase activity database_cross_reference “RHEA:52052”
FAHFA hydrolase activity database_cross_reference “RHEA:52076”
FAHFA hydrolase activity narrowMatch 52056
FAHFA hydrolase activity narrowMatch 52096
FAHFA hydrolase activity narrowMatch 52052
FAHFA hydrolase activity database_cross_reference “RHEA:52096”
FAHFA hydrolase activity definition “Catalysis of the hydrolysis of the ester bond in a fatty acid ester of a hydroxy fatty acid (FAHFA), yielding a free fatty acid and a hydroxy fatty acid. FAHFAs are a class of endogenous bioactive signaling lipids in which a fatty acid is esterified to a hydroxyl group on a second fatty acid backbone.”
- database_cross_reference “PMID:32152231”
- database_cross_reference “PMID:27018888”
FAHFA hydrolase activity narrowMatch 52084
FAHFA hydrolase activity narrowMatch 52068
FAHFA hydrolase activity has_exact_synonym “fatty-acid ester of hydroxy-fatty-acid hydrolase activity”
FAHFA hydrolase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31722”^^anyURI
FAHFA hydrolase activity database_cross_reference “RHEA:52080”
FAHFA hydrolase activity narrowMatch 52076
FAHFA hydrolase activity database_cross_reference “RHEA:52068”
FAHFA hydrolase activity narrowMatch 52048
FAHFA hydrolase activity id “GO:0120573”
FAHFA hydrolase activity database_cross_reference “RHEA:52060”
FAHFA hydrolase activity label “FAHFA hydrolase activity”
FAHFA hydrolase activity database_cross_reference “RHEA:52092”
FAHFA hydrolase activity narrowMatch 52064
FAHFA hydrolase activity database_cross_reference “RHEA:52048”
FAHFA hydrolase activity creation date “2026-03-13T16:05:52Z”
FAHFA hydrolase activity database_cross_reference “RHEA:52072”
FAHFA hydrolase activity narrowMatch 52092
FAHFA hydrolase activity narrowMatch 52060
FAHFA hydrolase activity database_cross_reference “RHEA:52056”
Class: FAHFA hydrolase activity
FAHFA hydrolase activity SubClassOf carboxylic ester hydrolase activity

FH1 domain binding `http://purl.obolibrary.org/obo/GO_0017058`

Removed

FH1 domain binding definition “Binding to a FH1 domain of a protein, a proline-rich domain, usually located in front of a FH2 domain.”
- database_cross_reference “GOC:go_curators”

Added

FH1 domain binding definition “Binding to a FH1 domain of a protein, a proline-rich domain, usually located in front of a FH2 domain.”
- database_cross_reference “GOC:curators”

G protein activity `http://purl.obolibrary.org/obo/GO_0003925`

Removed

G protein activity database_cross_reference “Reactome:R-HSA-400037”
- label “Gi,Go Heterotrimeric G-protein complex dissociates”

GABA biosynthetic process `http://purl.obolibrary.org/obo/GO_0009449`

Removed

GABA biosynthetic process has_exact_synonym “GABA biosynthetic process”
GABA biosynthetic process label “gamma-aminobutyric acid biosynthetic process”
GABA biosynthetic process comment “See also the biological process term ‘neurotransmitter biosynthetic process ; GO:0042136’.”

Added

GABA biosynthetic process comment “See also the biological process term ‘neurotransmitter biosynthetic process ; GO:0042136’ and ‘GABA shunt ; GO:0006540’.”
GABA biosynthetic process label “GABA biosynthetic process”
GABA biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31732”^^anyURI
GABA biosynthetic process has_exact_synonym “gamma-aminobutyric acid biosynthetic process”

GABA catabolic process `http://purl.obolibrary.org/obo/GO_0009450`

Removed

GABA catabolic process has_exact_synonym “GABA catabolic process”
GABA catabolic process comment “See also the biological process term ‘neurotransmitter catabolic process ; GO:0042135’.”
GABA catabolic process label “gamma-aminobutyric acid catabolic process”
GABA catabolic process definition “The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.”
- database_cross_reference “GOC:ai”

Added

GABA catabolic process label “GABA catabolic process”
GABA catabolic process definition “The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA).”
- database_cross_reference “GOC:curators”
GABA catabolic process comment “See also the biological process term ‘neurotransmitter catabolic process ; GO:0042135’ and ‘GABA shunt ; GO:0006540’.”
GABA catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI
GABA catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31732”^^anyURI
GABA catabolic process has_exact_synonym “gamma-aminobutyric acid catabolic process”

GABA metabolic process `http://purl.obolibrary.org/obo/GO_0009448`

Removed

GABA metabolic process has_exact_synonym “GABA metabolic process”
GABA metabolic process label “gamma-aminobutyric acid metabolic process”

Added

GABA metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31732”^^anyURI
GABA metabolic process label “GABA metabolic process”
GABA metabolic process has_exact_synonym “gamma-aminobutyric acid metabolic process”

GABA shunt `http://purl.obolibrary.org/obo/GO_0006540`

Removed

GABA shunt has_exact_synonym “glutamate degradation via 4-aminobutyrate”
- database_cross_reference “MetaCyc:GLUDEG-I-PWY”
GABA shunt has_exact_synonym “glutamate degradation via GABA”
- database_cross_reference “MetaCyc:GLUDEG-I-PWY”
GABA shunt definition “The chemical reactions and pathways resulting in the formation of succinate from L-glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes.”
- database_cross_reference “PMID:12740438”
GABA shunt comment “Note that the third step in this pathway (conversion of succinate semialdehyde to succinate) can be catalyzed by NAD-dependent or NADP-dependent succinate semialdehyde dehydrogenase (EC:1.2.1.24 and EC:1.2.1.79, respectively).”
GABA shunt label “gamma-aminobutyrate shunt”
GABA shunt has_exact_synonym “GABA shunt”
GABA shunt has_exact_synonym “degradation of glutamate to succinate through GABA”
- database_cross_reference “MetaCyc:GLUDEG-I-PWY”
GABA shunt SubClassOf L-glutamate catabolic process
GABA shunt SubClassOf has part some 4-aminobutyrate:2-oxoglutarate transaminase activity
GABA shunt SubClassOf has part some glutamate decarboxylase activity

Added

GABA shunt label “GABA shunt”
GABA shunt definition “The chemical reactions and pathways resulting in the formation of succinate from L-glutamate via gamma-aminobutyrate (GABA), bypassing two steps of the TCA cycle. It operates through the sequential conversion of glutamate to GABA by glutamate decarboxylase, transamination of GABA to succinic semialdehyde by GABA transaminase, and oxidation of succinic semialdehyde to succinate by succinate semialdehyde dehydrogenase.”
- database_cross_reference “PMID:39703920”
GABA shunt has_exact_synonym “gamma-aminobutyrate shunt”
GABA shunt term tracker item “https://github.com/geneontology/go-ontology/issues/31732”^^anyURI
GABA shunt SubClassOf L-amino acid metabolic process
GABA shunt SubClassOf proteinogenic amino acid metabolic process
GABA shunt SubClassOf glutamate metabolic process

GDP phosphatase activity `http://purl.obolibrary.org/obo/GO_0004382`

Added

GDP phosphatase activity database_cross_reference “Reactome:R-HSA-9947887”
- label “GBP1 hydrolyzes GDP”

GDP-L-fucose synthase activity `http://purl.obolibrary.org/obo/GO_0050577`

Removed

GDP-L-fucose synthase activity database_cross_reference “Reactome:R-HSA-6787642”
- label “TSTA3 dimer reduces GDP-KDGal to GDP-Fuc”

Added

GDP-L-fucose synthase activity database_cross_reference “Reactome:R-HSA-6787642”
- label “GFUS dimer reduces GDP-KDGal to GDP-Fuc”

GDP-fucose transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0005457`

Removed

GDP-fucose transmembrane transporter activity database_cross_reference “Reactome:R-HSA-742345”
- label “SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen”

Added

GDP-fucose transmembrane transporter activity database_cross_reference “Reactome:R-HSA-742345”
- label “SLC35C1 transport GDP-Fuc from cytosol to Golgi lumen”

GDP-mannose transmembrane transport `http://purl.obolibrary.org/obo/GO_1990570`

Added

GDP-mannose transmembrane transport term tracker item “https://github.com/geneontology/go-ontology/issues/27059”^^anyURI
GDP-mannose transmembrane transport SubClassOf organic anion transport

GDP-perosamine synthase activity `http://purl.obolibrary.org/obo/GO_0102933`

Removed

GDP-perosamine synthase activity label “GDP-4-dehydro-6-deoxy-D-mannose-4-aminotransferase activity”
GDP-perosamine synthase activity definition “Catalysis of the reaction: GDP-4-amino-4,6-dideoxy-alpha-D-mannose + 2-oxoglutarate = GDP-4-dehydro-6-deoxy-alpha-D-mannose + L-glutamate.”
- database_cross_reference “GOC:pz”
- database_cross_reference “RHEA:36779”

Added

GDP-perosamine synthase activity has_exact_synonym “GDP-4-dehydro-6-deoxy-D-mannose-4-aminotransferase activity”
GDP-perosamine synthase activity definition “Catalysis of the reaction: GDP-alpha-D-perosamine + 2-oxoglutarate = GDP-4-dehydro-alpha-D-rhamnose + L-glutamate.”
- database_cross_reference “RHEA:36779”
GDP-perosamine synthase activity label “GDP-perosamine synthase activity”
GDP-perosamine synthase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI

GMP catabolic process `http://purl.obolibrary.org/obo/GO_0046038`

Removed

GMP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of GMP, guanosine monophosphate.”
- database_cross_reference “GOC:go_curators”

Added

GMP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of GMP, guanosine monophosphate.”
- database_cross_reference “GOC:curators”

GMP metabolic process `http://purl.obolibrary.org/obo/GO_0046037`

Removed

GMP metabolic process definition “The chemical reactions and pathways involving GMP, guanosine monophosphate.”
- database_cross_reference “GOC:go_curators”

Added

GMP metabolic process definition “The chemical reactions and pathways involving GMP, guanosine monophosphate.”
- database_cross_reference “GOC:curators”

GMP synthase activity `http://purl.obolibrary.org/obo/GO_0003921`

Removed

GMP synthase activity definition “Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H+.”
- database_cross_reference “RHEA:18301”

Added

GMP synthase activity definition “Catalysis of the reaction: ATP + XMP + NH4+ = AMP + diphosphate + GMP + 2H+.”
- database_cross_reference “RHEA:18301”

GO_0019291 `http://purl.obolibrary.org/obo/GO_0019291`

Removed

GO_0019291 term replaced by obsolete L-tyrosine biosynthetic process, by oxidation of phenylalanine

Added

GO_0019291 term replaced by L-tyrosine biosynthetic process

GPI anchor binding `http://purl.obolibrary.org/obo/GO_0034235`

Removed

GPI anchor binding SubClassOf phosphatidylinositol binding

Added

GPI anchor binding SubClassOf phospholipid binding

GPI anchor biosynthetic process `http://purl.obolibrary.org/obo/GO_0006506`

Removed

GPI anchor biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198547684”
GPI anchor biosynthetic process SubClassOf phosphatidylinositol biosynthetic process

Added

GPI anchor biosynthetic process database_cross_reference “MetaCyc:PWY-8600”
GPI anchor biosynthetic process narrowMatch PWY-8601
GPI anchor biosynthetic process narrowMatch PWY-8600
GPI anchor biosynthetic process database_cross_reference “MetaCyc:PWY-8601”
GPI anchor biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/30568”^^anyURI
GPI anchor biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198547684”
GPI anchor biosynthetic process SubClassOf glycerophospholipid biosynthetic process

GPI anchor metabolic process `http://purl.obolibrary.org/obo/GO_0006505`

Removed

GPI anchor metabolic process SubClassOf phosphatidylinositol metabolic process

Added

GPI anchor metabolic process SubClassOf glycerophospholipid metabolic process

GPI anchor phospholipase C activity `http://purl.obolibrary.org/obo/GO_0140335`

Added

GPI anchor phospholipase C activity database_cross_reference “RHEA:86259”
GPI anchor phospholipase C activity narrowMatch 86259

GPI anchor phospholipase D activity `http://purl.obolibrary.org/obo/GO_0004621`

Removed

GPI anchor phospholipase D activity definition “Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol, by cleavage of the second phosphodiester bond between the phosphate and phospholipid.”
- database_cross_reference “PMID:2760042”

Added

GPI anchor phospholipase D activity exactMatch 86263
GPI anchor phospholipase D activity definition “Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol, by cleavage of the second phosphodiester bond between the phosphate and phospholipid.”
- database_cross_reference “RHEA:86263”
- database_cross_reference “PMID:2760042”
GPI anchor phospholipase D activity database_cross_reference “RHEA:86263”

GPI anchor remodelling `http://purl.obolibrary.org/obo/GO_0120574`

Added

GPI anchor remodelling has_obo_namespace “biological_process”
GPI anchor remodelling created by “sjm”
GPI anchor remodelling narrowMatch PWY-8603
GPI anchor remodelling id “GO:0120574”
GPI anchor remodelling label “GPI anchor remodelling”
GPI anchor remodelling database_cross_reference “MetaCyc:PWY-8603”
GPI anchor remodelling term tracker item “https://github.com/geneontology/go-ontology/issues/30568”^^anyURI
GPI anchor remodelling definition “Any process leading to the modification of the GPI-anchor after its transfer and attachment to a protein.”
- database_cross_reference “PMID:32156170”
GPI anchor remodelling creation date “2026-03-23T16:23:47Z”
GPI anchor remodelling narrowMatch PWY-8602
GPI anchor remodelling database_cross_reference “MetaCyc:PWY-8602”
Class: GPI anchor remodelling
GPI anchor remodelling SubClassOf protein maturation
GPI anchor remodelling SubClassOf part of some GPI anchored protein biosynthesis

GTP metabolic process `http://purl.obolibrary.org/obo/GO_0046039`

Removed

GTP metabolic process definition “The chemical reactions and pathways involving GTP, guanosine triphosphate.”
- database_cross_reference “GOC:go_curators”

Added

GTP metabolic process definition “The chemical reactions and pathways involving GTP, guanosine triphosphate.”
- database_cross_reference “GOC:curators”

GTP-dependent protein binding `http://purl.obolibrary.org/obo/GO_0030742`

Removed

GTP-dependent protein binding definition “Binding to a protein or protein complex when at least one of the interacting partners is in the GTP-bound state.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:krc”

Added

GTP-dependent protein binding definition “Binding to a protein or protein complex when at least one of the interacting partners is in the GTP-bound state.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:krc”

GTPase activity `http://purl.obolibrary.org/obo/GO_0003924`

Added

GTPase activity database_cross_reference “Reactome:R-HSA-9954919”
- label “ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released”
GTPase activity database_cross_reference “Reactome:R-HSA-9947842”
- label “GBP1 hydrolyzes GTP forming GBP1 oligomers”

GW body `http://purl.obolibrary.org/obo/GO_0140364`

Removed

GW body SubClassOf cytoplasmic ribonucleoprotein granule

Added

GW body SubClassOf ribonucleoprotein granule

Glc3Man9GlcNAc2 oligosaccharide glucosidase activity `http://purl.obolibrary.org/obo/GO_0004573`

Added

Glc3Man9GlcNAc2 oligosaccharide glucosidase activity database_cross_reference “Reactome:R-HSA-9932344”
- label “MOGS removes terminal glucose from Glu3Man9GlcNAc2-CDH1”

Golgi lumen acidification `http://purl.obolibrary.org/obo/GO_0061795`

Removed

Golgi lumen acidification definition “Any process that reduces the pH of the Golgi lumen, measured by the concentration of the hydrogen ion.”
- database_cross_reference “GOC:dph”
- database_cross_reference “PMID:23447592”

Added

Golgi lumen acidification definition “Any process that reduces the pH of the Golgi lumen, corresponding to an increase in hydrogen ion concentration.”
- database_cross_reference “GOC:dph”
- database_cross_reference “PMID:23447592”

Golgi to endosome transport `http://purl.obolibrary.org/obo/GO_0006895`

Added

Golgi to endosome transport SubClassOf intercellular transport

Golgi to secretory granule transport `http://purl.obolibrary.org/obo/GO_0055107`

Added

Golgi to secretory granule transport SubClassOf intercellular transport

Golgi to vacuole transport `http://purl.obolibrary.org/obo/GO_0006896`

Added

Golgi to vacuole transport SubClassOf intercellular transport

HLH domain binding `http://purl.obolibrary.org/obo/GO_0043398`

Removed

HLH domain binding definition “Binding to a Helix Loop Helix domain, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “Prosite:PDOC0038”

Added

HLH domain binding definition “Binding to a Helix Loop Helix domain, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.”
- database_cross_reference “GOC:curators”
- database_cross_reference “Prosite:PDOC0038”

HNK-1 sulfotransferase activity `http://purl.obolibrary.org/obo/GO_0016232`

Added

HNK-1 sulfotransferase activity database_cross_reference “Reactome:R-HSA-9940718”
- label “CHST10 sulfates matriglycan chain”

IMP metabolic process `http://purl.obolibrary.org/obo/GO_0046040`

Removed

IMP metabolic process definition “The chemical reactions and pathways involving IMP, inosine monophosphate.”
- database_cross_reference “GOC:go_curators”

Added

IMP metabolic process definition “The chemical reactions and pathways involving IMP, inosine monophosphate.”
- database_cross_reference “GOC:curators”

ISG15 activating enzyme activity `http://purl.obolibrary.org/obo/GO_0019782`

Added

ISG15 activating enzyme activity database_cross_reference “Reactome:R-HSA-1169397”
- label “Activation of ISG15 by UBA7 E1 enzyme”

ISG15 conjugating enzyme activity `http://purl.obolibrary.org/obo/GO_0061653`

Added

ISG15 conjugating enzyme activity database_cross_reference “Reactome:R-HSA-1169404”
- label “Transfer of ISG15 from E1 to E2 (UBCH8)”

ISG15 ligase activity `http://purl.obolibrary.org/obo/GO_0061662`

Added

ISG15 ligase activity database_cross_reference “Reactome:R-HSA-1169395”
- label “ISGylation of viral protein NS1”
ISG15 ligase activity database_cross_reference “Reactome:R-HSA-1169394”
- label “ISGylation of IRF3”
ISG15 ligase activity database_cross_reference “Reactome:R-HSA-1169406”
- label “ISGylation of host proteins”
ISG15 ligase activity database_cross_reference “Reactome:R-HSA-1169398”
- label “ISGylation of host protein filamin B”
ISG15 ligase activity database_cross_reference “Reactome:R-HSA-9833973”
- label “ISGylation of PKR”
ISG15 ligase activity database_cross_reference “Reactome:R-HSA-1169405”
- label “ISGylation of protein phosphatase 1 beta (PP2CB)”
ISG15 ligase activity database_cross_reference “Reactome:R-HSA-1169402”
- label “ISGylation of E2 conjugating enzymes”

ISG15 transferase activity `http://purl.obolibrary.org/obo/GO_0042296`

Added

ISG15 transferase activity database_cross_reference “Reactome:R-HSA-9927247”
- label “ISGylation of DDX58 (RIG-I)”

ITP biosynthetic process `http://purl.obolibrary.org/obo/GO_0046042`

Removed

ITP biosynthetic process definition “The chemical reactions and pathways resulting in the formation of ITP, inosine triphosphate.”
- database_cross_reference “GOC:go_curators”

Added

ITP biosynthetic process definition “The chemical reactions and pathways resulting in the formation of ITP, inosine triphosphate.”
- database_cross_reference “GOC:curators”

ITP metabolic process `http://purl.obolibrary.org/obo/GO_0046041`

Removed

ITP metabolic process definition “The chemical reactions and pathways involving ITP, inosine triphosphate.”
- database_cross_reference “GOC:go_curators”

Added

ITP metabolic process definition “The chemical reactions and pathways involving ITP, inosine triphosphate.”
- database_cross_reference “GOC:curators”

L,L-diaminopimelate:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0010285`

Removed

L,L-diaminopimelate:2-oxoglutarate transaminase activity label “L,L-diaminopimelate aminotransferase activity”
L,L-diaminopimelate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + LL-2,6-diaminopimelate = (S)-2,3,4,5-tetrahydrodipicolinate + L-glutamate + H2O + H+.”
- database_cross_reference “RHEA:23988”
- database_cross_reference “EC:2.6.1.83”

Added

L,L-diaminopimelate:2-oxoglutarate transaminase activity has_exact_synonym “L,L-diaminopimelate aminotransferase activity”
L,L-diaminopimelate:2-oxoglutarate transaminase activity label “L,L-diaminopimelate:2-oxoglutarate transaminase activity”
L,L-diaminopimelate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + LL-2,6-diaminopimelate = (S)-2,3,4,5-tetrahydrodipicolinate + L-glutamate + H2O + H+.”
- database_cross_reference “RHEA:23988”
L,L-diaminopimelate:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI

L-2,4-diaminobutyrate:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0045303`

Removed

L-2,4-diaminobutyrate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + L-2,4-diaminobutyrate = L-aspartate 4-semialdehyde + L-glutamate.”
- database_cross_reference “RHEA:11160”
- database_cross_reference “EC:2.6.1.76”
L-2,4-diaminobutyrate:2-oxoglutarate transaminase activity label “diaminobutyrate-2-oxoglutarate transaminase activity”

Added

L-2,4-diaminobutyrate:2-oxoglutarate transaminase activity has_exact_synonym “diaminobutyrate-2-oxoglutarate transaminase activity”
L-2,4-diaminobutyrate:2-oxoglutarate transaminase activity label “L-2,4-diaminobutyrate:2-oxoglutarate transaminase activity”
L-2,4-diaminobutyrate:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-2,4-diaminobutyrate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: L-2,4-diaminobutanoate + 2-oxoglutarate = L-aspartate 4-semialdehyde + L-glutamate.”
- database_cross_reference “RHEA:11160”

L-2,4-diaminobutyrate:pyruvate transaminase activity `http://purl.obolibrary.org/obo/GO_0047307`

Removed

L-2,4-diaminobutyrate:pyruvate transaminase activity definition “Catalysis of the reaction: L-2,4-diaminobutyrate + pyruvate = L-alanine + L-aspartate 4-semialdehyde.”
- database_cross_reference “RHEA:12380”
- database_cross_reference “EC:2.6.1.46”
L-2,4-diaminobutyrate:pyruvate transaminase activity label “diaminobutyrate-pyruvate transaminase activity”

Added

L-2,4-diaminobutyrate:pyruvate transaminase activity definition “Catalysis of the reaction: L-2,4-diaminobutyrate + pyruvate = L-alanine + L-aspartate 4-semialdehyde.”
- database_cross_reference “RHEA:12380”
L-2,4-diaminobutyrate:pyruvate transaminase activity label “L-2,4-diaminobutyrate:pyruvate transaminase activity”
L-2,4-diaminobutyrate:pyruvate transaminase activity has_exact_synonym “diaminobutyrate-pyruvate transaminase activity”
L-2,4-diaminobutyrate:pyruvate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI

L-2-aminoadipate:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0047536`

Removed

L-2-aminoadipate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate.”
- database_cross_reference “RHEA:12601”
- database_cross_reference “EC:2.6.1.39”
L-2-aminoadipate:2-oxoglutarate transaminase activity label “2-aminoadipate transaminase activity”

Added

L-2-aminoadipate:2-oxoglutarate transaminase activity label “L-2-aminoadipate:2-oxoglutarate transaminase activity”
L-2-aminoadipate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate.”
- database_cross_reference “RHEA:12601”
L-2-aminoadipate:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-2-aminoadipate:2-oxoglutarate transaminase activity has_exact_synonym “2-aminoadipate transaminase activity”

L-2-aminohexanoate:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0047537`

Removed

L-2-aminohexanoate:2-oxoglutarate transaminase activity label “2-aminohexanoate transaminase activity”
L-2-aminohexanoate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: L-2-aminohexanoate + 2-oxoglutarate = 2-oxohexanoate + L-glutamate.”
- database_cross_reference “MetaCyc:2-AMINOHEXANOATE-AMINOTRANSFERASE-RXN”
- database_cross_reference “EC:2.6.1.67”

Added

L-2-aminohexanoate:2-oxoglutarate transaminase activity label “L-2-aminohexanoate:2-oxoglutarate transaminase activity”
L-2-aminohexanoate:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-2-aminohexanoate:2-oxoglutarate transaminase activity has_exact_synonym “2-aminohexanoate transaminase activity”
L-2-aminohexanoate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: L-2-aminohexanoate + 2-oxoglutarate = 2-oxohexanoate + L-glutamate.”
- database_cross_reference “RHEA:23600”

L-2-hydroxycarboxylate dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0102443`

Added

L-alanine biosynthetic process `http://purl.obolibrary.org/obo/GO_0042852`

Removed

L-alanine biosynthetic process database_cross_reference “MetaCyc:PWY0-1061”
L-alanine biosynthetic process exactMatch PWY0-1061
L-alanine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:jl”
- database_cross_reference “MetaCyc:PWY0-1061”
- database_cross_reference “GOC:jsg”
L-alanine biosynthetic process SubClassOf obsolete L-alanine metabolic process

Added

L-alanine biosynthetic process database_cross_reference “MetaCyc:PWY0-1021”
L-alanine biosynthetic process database_cross_reference “MetaCyc:ALANINE-VALINESYN-PWY”
L-alanine biosynthetic process narrowMatch ALANINE-SYN2-PWY
L-alanine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:jsg”
L-alanine biosynthetic process narrowMatch ALANINE-VALINESYN-PWY
L-alanine biosynthetic process database_cross_reference “MetaCyc:ALANINE-SYN2-PWY”
L-alanine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
L-alanine biosynthetic process narrowMatch PWY0-1021

L-alanine catabolic process `http://purl.obolibrary.org/obo/GO_0042853`

Removed

L-alanine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:jsg”
L-alanine catabolic process SubClassOf obsolete L-alanine metabolic process

Added

L-alanine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-alanine.”
- database_cross_reference “GOC:curators”
L-alanine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI

L-alanine fermentation `http://purl.obolibrary.org/obo/GO_0019667`

Removed

L-alanine fermentation definition “The anaerobic chemical reactions and pathways resulting in the breakdown of L-alanine, yielding acetylCoA. AcetylCoA can be further converted to ATP.”
- database_cross_reference “GOC:jl”

Added

L-alanine fermentation definition “The anaerobic chemical reactions and pathways resulting in the breakdown of L-alanine, yielding acetylCoA. AcetylCoA can be further converted to ATP.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:38821505”

L-alanine transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015180`

Removed

L-alanine transmembrane transporter activity definition “Enables the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid.”
- database_cross_reference “GOC:mah”
- database_cross_reference “ISBN:0815340729”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_transport”
- database_cross_reference “GOC:jsg”
- database_cross_reference “ISBN:0198506732”

Added

L-alanine transmembrane transporter activity definition “Enables the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0815340729”
- database_cross_reference “GOC:mtg_transport”
- database_cross_reference “GOC:jsg”
- database_cross_reference “ISBN:0198506732”

L-alanine:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0004021`

Removed

L-alanine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.”
- database_cross_reference “RHEA:19453”
L-alanine:2-oxoglutarate transaminase activity comment “Note that this term has a MetaCyc pathway reference as the pathway only has a single step.”
L-alanine:2-oxoglutarate transaminase activity relatedMatch ALANINE-SYN2-PWY
L-alanine:2-oxoglutarate transaminase activity label “L-alanine:2-oxoglutarate aminotransferase activity”

Added

L-alanine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.”
- database_cross_reference “RHEA:19453”
L-alanine:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI
L-alanine:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-alanine:2-oxoglutarate transaminase activity has_exact_synonym “L-alanine:2-oxoglutarate aminotransferase activity”
L-alanine:2-oxoglutarate transaminase activity label “L-alanine:2-oxoglutarate transaminase activity”

L-alanine:glyoxylate transaminase activity `http://purl.obolibrary.org/obo/GO_0008453`

Removed

L-alanine:glyoxylate transaminase activity definition “Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine.”
- database_cross_reference “EC:2.6.1.44”
L-alanine:glyoxylate transaminase activity label “alanine-glyoxylate transaminase activity”
L-alanine:glyoxylate transaminase activity SubClassOf transaminase activity

Added

L-alanine:glyoxylate transaminase activity definition “Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine.”
- database_cross_reference “RHEA:24248”
L-alanine:glyoxylate transaminase activity label “L-alanine:glyoxylate transaminase activity”
L-alanine:glyoxylate transaminase activity has_exact_synonym “alanine-glyoxylate transaminase activity”
L-alanine:glyoxylate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-alanine:glyoxylate transaminase activity SubClassOf L-alanine:oxo-acid transaminase activity

L-alanine:oxo-acid transaminase activity `http://purl.obolibrary.org/obo/GO_0047635`

Removed

L-alanine:oxo-acid transaminase activity definition “Catalysis of the reaction: L-alanine + a 2-oxo acid = pyruvate + an L-amino acid.”
- database_cross_reference “MetaCyc:ALANINE–OXO-ACID-AMINOTRANSFERASE-RXN”
- database_cross_reference “EC:2.6.1.12”
L-alanine:oxo-acid transaminase activity label “alanine-oxo-acid transaminase activity”
L-alanine:oxo-acid transaminase activity SubClassOf transaminase activity

Added

L-alanine:oxo-acid transaminase activity database_cross_reference “RHEA:65920”
L-alanine:oxo-acid transaminase activity narrowMatch 77319
L-alanine:oxo-acid transaminase activity narrowMatch 77307
L-alanine:oxo-acid transaminase activity narrowMatch 77327
L-alanine:oxo-acid transaminase activity narrowMatch 81635
L-alanine:oxo-acid transaminase activity narrowMatch 77347
L-alanine:oxo-acid transaminase activity narrowMatch 65912
L-alanine:oxo-acid transaminase activity narrowMatch 77303
L-alanine:oxo-acid transaminase activity database_cross_reference “RHEA:68372”
L-alanine:oxo-acid transaminase activity label “L-alanine:oxo-acid transaminase activity”
L-alanine:oxo-acid transaminase activity narrowMatch 77355
L-alanine:oxo-acid transaminase activity database_cross_reference “RHEA:77355”
L-alanine:oxo-acid transaminase activity database_cross_reference “RHEA:65912”
L-alanine:oxo-acid transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-alanine:oxo-acid transaminase activity narrowMatch 13833
L-alanine:oxo-acid transaminase activity database_cross_reference “RHEA:13833”
L-alanine:oxo-acid transaminase activity database_cross_reference “RHEA:77319”
L-alanine:oxo-acid transaminase activity database_cross_reference “RHEA:77327”
L-alanine:oxo-acid transaminase activity narrowMatch 82415
L-alanine:oxo-acid transaminase activity database_cross_reference “RHEA:81635”
L-alanine:oxo-acid transaminase activity database_cross_reference “RHEA:77347”
L-alanine:oxo-acid transaminase activity database_cross_reference “RHEA:77307”
L-alanine:oxo-acid transaminase activity database_cross_reference “RHEA:82415”
L-alanine:oxo-acid transaminase activity database_cross_reference “RHEA:77303”
L-alanine:oxo-acid transaminase activity definition “Catalysis of the reaction: L-alanine + a 2-oxocarboxylate = an L-alpha-amino acid + pyruvate.”
- database_cross_reference “RHEA:19953”
L-alanine:oxo-acid transaminase activity narrowMatch 65920
L-alanine:oxo-acid transaminase activity narrowMatch 68372
L-alanine:oxo-acid transaminase activity SubClassOf amino acid transaminase activity

L-alanine:oxomalonate transaminase activity `http://purl.obolibrary.org/obo/GO_0047308`

Removed

L-alanine:oxomalonate transaminase activity definition “Catalysis of the reaction: L-alanine + oxomalonate = aminomalonate + pyruvate.”
- database_cross_reference “RHEA:18809”
- database_cross_reference “EC:2.6.1.47”
L-alanine:oxomalonate transaminase activity label “alanine-oxomalonate transaminase activity”
L-alanine:oxomalonate transaminase activity SubClassOf transaminase activity

Added

L-alanine:oxomalonate transaminase activity definition “Catalysis of the reaction: L-alanine + oxomalonate = aminomalonate + pyruvate.”
- database_cross_reference “RHEA:18809”
L-alanine:oxomalonate transaminase activity label “L-alanine:oxomalonate transaminase activity”
L-alanine:oxomalonate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-alanine:oxomalonate transaminase activity SubClassOf amino acid transaminase activity

L-amino acid metabolic process `http://purl.obolibrary.org/obo/GO_0170033`

Added

L-amino acid metabolic process database_cross_reference “Reactome:R-HSA-8964539”
- label “Glutamate and glutamine metabolism”
L-amino acid metabolic process database_cross_reference “Reactome:R-HSA-8963693”
- label “Aspartate and asparagine metabolism”

L-amino acid transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015179`

Added

L-amino acid transmembrane transporter activity database_cross_reference “Reactome:R-HSA-352232”
- label “SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol”

L-amino-acid N-acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0140085`

Removed

L-amino-acid N-acetyltransferase activity exactMatch 83863
L-amino-acid N-acetyltransferase activity definition “Catalysis of the reaction: acetyl-CoA + a L-amino acid = CoA + an N-acetyl-L-amino-acid. In some cases acetyl phosphate can be used as a donor.”
- database_cross_reference “GOC:pg”
- database_cross_reference “RHEA:83863”
L-amino-acid N-acetyltransferase activity SubClassOf N-acetyltransferase activity

Added

L-amino-acid N-acetyltransferase activity narrowMatch 83863
L-amino-acid N-acetyltransferase activity definition “Catalysis of the reaction: acetyl-CoA + a L-amino acid = CoA + an N-acetyl-L-amino-acid. In some cases other acetyl containing molecules can be used as donor.”
- database_cross_reference “GOC:pg”
- database_cross_reference “RHEA:83863”
L-amino-acid N-acetyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31474”^^anyURI
L-amino-acid N-acetyltransferase activity SubClassOf amino acid acyltransferase activity

L-amino-acid oxidase activity `http://purl.obolibrary.org/obo/GO_0001716`

Added

L-amino-acid oxidase activity narrowMatch 61344
L-amino-acid oxidase activity database_cross_reference “RHEA:61244”
L-amino-acid oxidase activity narrowMatch 61284
L-amino-acid oxidase activity database_cross_reference “RHEA:51404”
L-amino-acid oxidase activity database_cross_reference “RHEA:60996”
L-amino-acid oxidase activity narrowMatch 61248
L-amino-acid oxidase activity database_cross_reference “RHEA:61268”
L-amino-acid oxidase activity narrowMatch 61260
L-amino-acid oxidase activity narrowMatch 61276
L-amino-acid oxidase activity narrowMatch 61256
L-amino-acid oxidase activity database_cross_reference “RHEA:61284”
L-amino-acid oxidase activity database_cross_reference “RHEA:61276”
L-amino-acid oxidase activity database_cross_reference “RHEA:61344”
L-amino-acid oxidase activity database_cross_reference “RHEA:61236”
L-amino-acid oxidase activity database_cross_reference “RHEA:61260”
L-amino-acid oxidase activity narrowMatch 61268
L-amino-acid oxidase activity narrowMatch 61264
L-amino-acid oxidase activity database_cross_reference “RHEA:61252”
L-amino-acid oxidase activity narrowMatch 61228
L-amino-acid oxidase activity database_cross_reference “RHEA:61272”
L-amino-acid oxidase activity narrowMatch 19025
L-amino-acid oxidase activity narrowMatch 61236
L-amino-acid oxidase activity database_cross_reference “RHEA:19025”
L-amino-acid oxidase activity narrowMatch 60996
L-amino-acid oxidase activity narrowMatch 61232
L-amino-acid oxidase activity database_cross_reference “RHEA:61228”
L-amino-acid oxidase activity database_cross_reference “RHEA:61224”
L-amino-acid oxidase activity database_cross_reference “RHEA:61264”
L-amino-acid oxidase activity narrowMatch 61224
L-amino-acid oxidase activity database_cross_reference “RHEA:61232”
L-amino-acid oxidase activity database_cross_reference “RHEA:61256”
L-amino-acid oxidase activity narrowMatch 61244
L-amino-acid oxidase activity narrowMatch 51404
L-amino-acid oxidase activity narrowMatch 61252
L-amino-acid oxidase activity narrowMatch 61272
L-amino-acid oxidase activity database_cross_reference “RHEA:61248”

L-arabinose catabolic process to 2-oxoglutarate `http://purl.obolibrary.org/obo/GO_0019570`

Removed

L-arabinose catabolic process to 2-oxoglutarate definition “The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including 2-oxoglutarate.”
- database_cross_reference “GOC:go_curators”

Added

L-arabinose catabolic process to 2-oxoglutarate definition “The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including 2-oxoglutarate.”
- database_cross_reference “GOC:curators”

L-arabinose catabolic process to D-xylulose 5-phosphate `http://purl.obolibrary.org/obo/GO_0019569`

Removed

L-arabinose catabolic process to D-xylulose 5-phosphate definition “The chemical reactions and pathways resulting in the breakdown of L-arabinose into D-xylulose 5-phosphate.”
- database_cross_reference “GOC:go_curators”

Added

L-arabinose catabolic process to D-xylulose 5-phosphate definition “The chemical reactions and pathways resulting in the breakdown of L-arabinose into D-xylulose 5-phosphate.”
- database_cross_reference “GOC:curators”

L-arginine N-succinyltransferase activity `http://purl.obolibrary.org/obo/GO_0008791`

Removed

L-arginine N-succinyltransferase activity definition “Catalysis of the reaction: succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine.”
- database_cross_reference “EC:2.3.1.109”
L-arginine N-succinyltransferase activity label “arginine N-succinyltransferase activity”

Added

L-arginine N-succinyltransferase activity definition “Catalysis of the reaction: succinyl-CoA + L-arginine = N2-succinyl-L-arginine + CoA + H+.”
- database_cross_reference “RHEA:15185”
L-arginine N-succinyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31474”^^anyURI
L-arginine N-succinyltransferase activity label “L-arginine N-succinyltransferase activity”
L-arginine N-succinyltransferase activity has_broad_synonym “arginine N-succinyltransferase activity”
L-arginine N-succinyltransferase activity SubClassOf amino acid acyltransferase activity

L-arginine biosynthetic process `http://purl.obolibrary.org/obo/GO_0006526`

Added

L-arginine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
L-arginine biosynthetic process database_cross_reference “MetaCyc:PWY-5154”
L-arginine biosynthetic process narrowMatch PWY-5154

L-arginine catabolic process `http://purl.obolibrary.org/obo/GO_0006527`

Removed

L-arginine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-arginine, 2-amino-5-(carbamimidamido)pentanoic acid.”
- database_cross_reference “GOC:go_curators”

Added

L-arginine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-arginine.”
- database_cross_reference “GOC:curators”
L-arginine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI

L-ascorbate peroxidase activity `http://purl.obolibrary.org/obo/GO_0016688`

Removed

L-ascorbate peroxidase activity definition “Catalysis of the reaction: L-ascorbate + hydrogen peroxide = dehydroascorbate + 2 H2O.”
- database_cross_reference “EC:1.11.1.11”

Added

L-ascorbate peroxidase activity definition “Catalysis of the reaction: L-ascorbate + H2O2 = dehydroascorbate + 2 H2O.”
- database_cross_reference “EC:1.11.1.11”

L-ascorbic acid catabolic process `http://purl.obolibrary.org/obo/GO_0019854`

Removed

L-ascorbic acid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions.”
- database_cross_reference “GOC:go_curators”

Added

L-ascorbic acid catabolic process narrowMatch PWY-6961
L-ascorbic acid catabolic process narrowMatch PWY-6959
L-ascorbic acid catabolic process narrowMatch PWY-6704
L-ascorbic acid catabolic process database_cross_reference “MetaCyc:PWY-6961”
L-ascorbic acid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions.”
- database_cross_reference “GOC:curators”
L-ascorbic acid catabolic process database_cross_reference “MetaCyc:PWY-6959”
L-ascorbic acid catabolic process database_cross_reference “MetaCyc:PWY-6960”
L-ascorbic acid catabolic process narrowMatch PWY0-301
L-ascorbic acid catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
L-ascorbic acid catabolic process narrowMatch PWY-6960
L-ascorbic acid catabolic process database_cross_reference “MetaCyc:PWY-6704”

L-asparagine biosynthetic process `http://purl.obolibrary.org/obo/GO_0070981`

Removed

L-asparagine biosynthetic process SubClassOf obsolete L-asparagine metabolic process

Added

L-asparagine biosynthetic process database_cross_reference “MetaCyc:ASPARAGINESYN-PWY”
L-asparagine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
L-asparagine biosynthetic process database_cross_reference “MetaCyc:ASPARAGINE-BIOSYNTHESIS”
L-asparagine biosynthetic process narrowMatch ASPARAGINESYN-PWY
L-asparagine biosynthetic process narrowMatch ASPARAGINE-BIOSYNTHESIS
L-asparagine biosynthetic process SubClassOf asparagine metabolic process

L-asparagine catabolic process `http://purl.obolibrary.org/obo/GO_0006530`

Removed

L-asparagine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-asparagine, 2-amino-3-carbamoylpropanoic acid.”
- database_cross_reference “GOC:go_curators”
L-asparagine catabolic process SubClassOf obsolete L-asparagine metabolic process

Added

L-asparagine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-asparagine.”
- database_cross_reference “GOC:curators”
L-asparagine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI
L-asparagine catabolic process SubClassOf asparagine metabolic process

L-asparagine transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015182`

Removed

L-asparagine transmembrane transporter activity definition “Enables the transfer of L-asparagine from one side of a membrane to the other. L-asparagine is the L-enantiomer of alpha-aminosuccinamic acid.”
- database_cross_reference “GOC:mah”
- database_cross_reference “ISBN:0815340729”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_transport”
- database_cross_reference “GOC:jsg”
- database_cross_reference “ISBN:0198506732”

Added

L-asparagine transmembrane transporter activity definition “Enables the transfer of L-asparagine from one side of a membrane to the other. L-asparagine is the L-enantiomer of alpha-aminosuccinamic acid.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0815340729”
- database_cross_reference “GOC:mtg_transport”
- database_cross_reference “GOC:jsg”
- database_cross_reference “ISBN:0198506732”

L-asparagine:oxo-acid transaminase activity `http://purl.obolibrary.org/obo/GO_0047297`

Removed

L-asparagine:oxo-acid transaminase activity label “asparagine-oxo-acid transaminase activity”
L-asparagine:oxo-acid transaminase activity definition “Catalysis of the reaction: a 2-oxo acid + L-asparagine = an amino acid + 2-oxosuccinamate.”
- database_cross_reference “RHEA:19813”
L-asparagine:oxo-acid transaminase activity SubClassOf transaminase activity

Added

L-asparagine:oxo-acid transaminase activity database_cross_reference “RHEA:52528”
L-asparagine:oxo-acid transaminase activity narrowMatch 52528
L-asparagine:oxo-acid transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-asparagine:oxo-acid transaminase activity narrowMatch 68380
L-asparagine:oxo-acid transaminase activity database_cross_reference “RHEA:68376”
L-asparagine:oxo-acid transaminase activity database_cross_reference “RHEA:68380”
L-asparagine:oxo-acid transaminase activity label “L-asparagine:oxo-acid transaminase activity”
L-asparagine:oxo-acid transaminase activity narrowMatch 68376
L-asparagine:oxo-acid transaminase activity has_exact_synonym “asparagine-oxo-acid transaminase activity”
L-asparagine:oxo-acid transaminase activity definition “Catalysis of the reaction: L-asparagine + a 2-oxocarboxylate = 2-oxosuccinamate + an L-alpha-amino acid.”
- database_cross_reference “RHEA:19813”
L-asparagine:oxo-acid transaminase activity SubClassOf amino acid transaminase activity

L-aspartate N-acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0017188`

Removed

L-aspartate N-acetyltransferase activity database_cross_reference “Reactome:R-HSA-8954468”
- label “NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA”

Added

L-aspartate N-acetyltransferase activity database_cross_reference “Reactome:R-HSA-8954468”
- label “NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAASP”

L-aspartate biosynthetic process `http://purl.obolibrary.org/obo/GO_0006532`

Removed

L-aspartate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “MetaCyc:ASPARTATESYN-PWY”
- database_cross_reference “ISBN:0198506732”

Added

L-aspartate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.”
- database_cross_reference “GOC:curators”
- database_cross_reference “MetaCyc:ASPARTATESYN-PWY”
- database_cross_reference “ISBN:0198506732”

L-aspartate catabolic process `http://purl.obolibrary.org/obo/GO_0006533`

Removed

L-aspartate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

L-aspartate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI
L-aspartate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-aspartate.”
- database_cross_reference “GOC:curators”

L-aspartate transmembrane export from vacuole `http://purl.obolibrary.org/obo/GO_0089703`

Added

L-aspartate transmembrane export from vacuole SubClassOf intercellular transport

L-aspartate transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015183`

Removed

L-aspartate transmembrane transporter activity definition “Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid.”
- database_cross_reference “ISBN:0815340729”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_transport”
- database_cross_reference “ISBN:0198506732”

Added

L-aspartate transmembrane transporter activity definition “Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0815340729”
- database_cross_reference “GOC:mtg_transport”
- database_cross_reference “ISBN:0198506732”

L-aspartate:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0004069`

Removed

L-aspartate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.”
- database_cross_reference “EC:2.6.1.1”
L-aspartate:2-oxoglutarate transaminase activity label “L-aspartate:2-oxoglutarate aminotransferase activity”
L-aspartate:2-oxoglutarate transaminase activity comment “Note that this term has a MetaCyc pathway reference as the pathway only has a single step.”
L-aspartate:2-oxoglutarate transaminase activity relatedMatch ASPARTATESYN-PWY
L-aspartate:2-oxoglutarate transaminase activity relatedMatch ASPARTATE-DEG1-PWY
L-aspartate:2-oxoglutarate transaminase activity database_cross_reference “Reactome:R-HSA-70596”
- label “GOT2 dimer deaminates L-Asp”
L-aspartate:2-oxoglutarate transaminase activity SubClassOf transaminase activity

Added

L-aspartate:2-oxoglutarate transaminase activity has_exact_synonym “L-aspartate:2-oxoglutarate aminotransferase activity”
L-aspartate:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-aspartate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.”
- database_cross_reference “RHEA:21824”
L-aspartate:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI
L-aspartate:2-oxoglutarate transaminase activity label “L-aspartate:2-oxoglutarate transaminase activity”
L-aspartate:2-oxoglutarate transaminase activity database_cross_reference “Reactome:R-HSA-70596”
- label “GOT2 dimer transaminates L-Asp”
L-aspartate:2-oxoglutarate transaminase activity SubClassOf amino acid transaminase activity

L-aspartate:phenylpyruvate transaminase activity `http://purl.obolibrary.org/obo/GO_0047319`

Removed

L-aspartate:phenylpyruvate transaminase activity label “aspartate-phenylpyruvate transaminase activity”
L-aspartate:phenylpyruvate transaminase activity definition “Catalysis of the reaction: keto-phenylpyruvate + L-aspartate = L-phenylalanine + oxaloacetate.”
- database_cross_reference “RHEA:14097”
L-aspartate:phenylpyruvate transaminase activity SubClassOf transaminase activity

Added

L-aspartate:phenylpyruvate transaminase activity label “L-aspartate:phenylpyruvate transaminase activity”
L-aspartate:phenylpyruvate transaminase activity has_exact_synonym “aspartate-phenylpyruvate transaminase activity”
L-aspartate:phenylpyruvate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-aspartate:phenylpyruvate transaminase activity definition “Catalysis of the reaction: L-aspartate + 3-phenylpyruvate = oxaloacetate + L-phenylalanine.”
- database_cross_reference “RHEA:14097”
L-aspartate:phenylpyruvate transaminase activity SubClassOf amino acid transaminase activity

L-aspartate:prephenate transaminase activity `http://purl.obolibrary.org/obo/GO_0033853`

Removed

L-aspartate:prephenate transaminase activity label “aspartate-prephenate aminotransferase activity”
L-aspartate:prephenate transaminase activity SubClassOf transaminase activity

Added

L-aspartate:prephenate transaminase activity label “L-aspartate:prephenate transaminase activity”
L-aspartate:prephenate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-aspartate:prephenate transaminase activity has_exact_synonym “aspartate-prephenate aminotransferase activity”
L-aspartate:prephenate transaminase activity SubClassOf amino acid transaminase activity

L-citrulline catabolic process `http://purl.obolibrary.org/obo/GO_0019241`

Removed

L-citrulline catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins.”
- database_cross_reference “ISBN:0198506732”

Added

L-citrulline catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI
L-citrulline catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-citrulline.”
- database_cross_reference “GOC:curators”

L-cysteine biosynthetic process `http://purl.obolibrary.org/obo/GO_0019344`

Removed

L-cysteine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of L-cysteine, 2-amino-3-mercaptopropanoic acid.”
- database_cross_reference “GOC:go_curators”
L-cysteine biosynthetic process SubClassOf obsolete L-cysteine metabolic process

Added

L-cysteine biosynthetic process database_cross_reference “MetaCyc:PWY-I9”
L-cysteine biosynthetic process database_cross_reference “MetaCyc:PWY-6308”
L-cysteine biosynthetic process narrowMatch PWY-8010
L-cysteine biosynthetic process narrowMatch PWY-8009
L-cysteine biosynthetic process database_cross_reference “MetaCyc:PWY-8009”
L-cysteine biosynthetic process narrowMatch PWY-6308
L-cysteine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
L-cysteine biosynthetic process database_cross_reference “MetaCyc:PWY-7870”
L-cysteine biosynthetic process narrowMatch CYSTSYN-PWY
L-cysteine biosynthetic process narrowMatch PWY-7870
L-cysteine biosynthetic process database_cross_reference “MetaCyc:HOMOCYSDEGR-PWY”
L-cysteine biosynthetic process narrowMatch PWY-7289
L-cysteine biosynthetic process database_cross_reference “MetaCyc:PWY-8010”
L-cysteine biosynthetic process database_cross_reference “MetaCyc:PWY-7289”
L-cysteine biosynthetic process database_cross_reference “MetaCyc:CYSTSYN-PWY”
L-cysteine biosynthetic process narrowMatch PWY-I9
L-cysteine biosynthetic process narrowMatch HOMOCYSDEGR-PWY
L-cysteine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of L-cysteine, 2-amino-3-mercaptopropanoic acid.”
- database_cross_reference “GOC:curators”

L-cysteine catabolic process `http://purl.obolibrary.org/obo/GO_0019448`

Removed

L-cysteine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:jsg”
L-cysteine catabolic process SubClassOf obsolete L-cysteine metabolic process

Added

L-cysteine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-cysteine.”
- database_cross_reference “GOC:curators”
L-cysteine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI

L-cysteine desulfhydrase activity `http://purl.obolibrary.org/obo/GO_0080146`

Removed

L-cysteine desulfhydrase activity database_cross_reference “Reactome:R-HSA-1614591”
- label “Excess cysteine yields lanthionine and H2S”
L-cysteine desulfhydrase activity database_cross_reference “Reactome:R-HSA-1614614”
- label “Cysteine is degraded to serine and H2S”

L-cysteine-S-conjugate N-acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0047198`

Removed

L-cysteine-S-conjugate N-acetyltransferase activity definition “Catalysis of the reaction: S-substituted L-cysteine + acetyl-CoA = S-substituted N-acetyl-L-cysteine + CoA + H+.”
- database_cross_reference “RHEA:19213”
- database_cross_reference “EC:2.3.1.80”

Added

L-cysteine-S-conjugate N-acetyltransferase activity definition “Catalysis of the reaction: S-substituted L-cysteine + acetyl-CoA = S-substituted N-acetyl-L-cysteine + CoA + H+.”
- database_cross_reference “RHEA:19213”
L-cysteine-S-conjugate N-acetyltransferase activity narrowMatch 75523
L-cysteine-S-conjugate N-acetyltransferase activity database_cross_reference “RHEA:75523”
L-cysteine-S-conjugate N-acetyltransferase activity database_cross_reference “RHEA:75511”
L-cysteine-S-conjugate N-acetyltransferase activity narrowMatch 75511

L-cysteine:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0047801`

Removed

L-cysteine:2-oxoglutarate transaminase activity label “L-cysteine transaminase activity”
L-cysteine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate.”
- database_cross_reference “RHEA:17441”
L-cysteine:2-oxoglutarate transaminase activity SubClassOf transaminase activity

Added

L-cysteine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: L-cysteine + 2-oxoglutarate = 2-oxo-3-sulfanylpropanoate + L-glutamate.”
- database_cross_reference “RHEA:17441”
L-cysteine:2-oxoglutarate transaminase activity label “L-cysteine:2-oxoglutarate transaminase activity”
L-cysteine:2-oxoglutarate transaminase activity has_broad_synonym “L-cysteine transaminase activity”
L-cysteine:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-cysteine:2-oxoglutarate transaminase activity SubClassOf amino acid transaminase activity

L-cystine L-cysteine-lyase (deaminating) activity `http://purl.obolibrary.org/obo/GO_0044540`

Removed

L-cystine L-cysteine-lyase (deaminating) activity definition “Catalysis of the reaction: L-cystine + H2O = pyruvate + NH3 + thiocysteine. Thiocysteine is also known as cysteine persulfide.”
- database_cross_reference “RHEA:24927”

Added

L-cystine L-cysteine-lyase (deaminating) activity definition “Catalysis of the reaction: L-cystine + H2O = S-sulfanyl-L-cysteine + pyruvate + NH4+.”
- database_cross_reference “RHEA:24927”

L-cystine transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015184`

Removed

L-cystine transmembrane transporter activity definition “Enables the transfer of L-cystine from one side of a membrane to the other.”
- database_cross_reference “ISBN:0815340729”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_transport”
- database_cross_reference “ISBN:0198506732”

Added

L-cystine transmembrane transporter activity definition “Enables the transfer of L-cystine from one side of a membrane to the other.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0815340729”
- database_cross_reference “GOC:mtg_transport”
- database_cross_reference “ISBN:0198506732”

L-cystine transport `http://purl.obolibrary.org/obo/GO_0015811`

Removed

L-cystine transport definition “The directed movement of L-cystine (also known as dicysteine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

L-cystine transport definition “The directed movement of L-cystine (also known as dicysteine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

L-diaminopimelate transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015626`

Removed

L-diaminopimelate transmembrane transporter activity definition “Enables the transfer of L-diaminopimelate from one side of a membrane to the other. L-diaminopimelate is the L-enantiomer anion of 2,6-diaminoheptanedioic acid.”
- database_cross_reference “GOC:mah”
- database_cross_reference “ISBN:0815340729”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_transport”
- database_cross_reference “GOC:jsg”
- database_cross_reference “ISBN:0198506732”

Added

L-diaminopimelate transmembrane transporter activity definition “Enables the transfer of L-diaminopimelate from one side of a membrane to the other. L-diaminopimelate is the L-enantiomer anion of 2,6-diaminoheptanedioic acid.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0815340729”
- database_cross_reference “GOC:mtg_transport”
- database_cross_reference “GOC:jsg”
- database_cross_reference “ISBN:0198506732”

L-dopa catabolic process `http://purl.obolibrary.org/obo/GO_0120575`

Added

L-dopa catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-dopa.”
- database_cross_reference “MetaCyc:PWY-8110”
- database_cross_reference “MetaCyc:PWY-6334”
L-dopa catabolic process created by “sjm”
L-dopa catabolic process label “L-dopa catabolic process”
L-dopa catabolic process has_obo_namespace “biological_process”
L-dopa catabolic process database_cross_reference “MetaCyc:PWY-8110”
L-dopa catabolic process database_cross_reference “MetaCyc:PWY-6334”
L-dopa catabolic process narrowMatch PWY-8110
L-dopa catabolic process creation date “2026-03-24T16:54:04Z”
L-dopa catabolic process id “GO:0120575”
L-dopa catabolic process narrowMatch PWY-6334
L-dopa catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31703”^^anyURI
Class: L-dopa catabolic process
L-dopa catabolic process SubClassOf L-amino acid catabolic process
L-dopa catabolic process SubClassOf non-proteinogenic amino acid catabolic process
L-dopa catabolic process SubClassOf aromatic amino acid family catabolic process
L-dopa catabolic process SubClassOf L-dopa metabolic process
L-dopa catabolic process SubClassOf modified amino acid catabolic process

L-fucose catabolic process `http://purl.obolibrary.org/obo/GO_0042355`

Removed

L-fucose catabolic process SubClassOf obsolete fucose catabolic process

Added

L-fucose catabolic process narrowMatch PWY-8444
L-fucose catabolic process database_cross_reference “MetaCyc:PWY-8318”
L-fucose catabolic process narrowMatch PWY-8318
L-fucose catabolic process narrowMatch FUCCAT-PWY
L-fucose catabolic process database_cross_reference “MetaCyc:PWY-8444”
L-fucose catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
L-fucose catabolic process database_cross_reference “MetaCyc:FUCCAT-PWY”
L-fucose catabolic process SubClassOf hexose catabolic process

L-glutamate N-acetyltransferase activity, acting on acetyl-CoA as donor `http://purl.obolibrary.org/obo/GO_0004042`

Removed

L-glutamate N-acetyltransferase activity, acting on acetyl-CoA as donor label “L-glutamate N-acetyltransferase activity”

Added

L-glutamate N-acetyltransferase activity, acting on acetyl-CoA as donor has_broad_synonym “L-glutamate N-acetyltransferase activity”
L-glutamate N-acetyltransferase activity, acting on acetyl-CoA as donor database_cross_reference “Reactome:R-HSA-9955697”
- label “NAGS variants don’t synthesize N-acetylglutamate”
L-glutamate N-acetyltransferase activity, acting on acetyl-CoA as donor label “L-glutamate N-acetyltransferase activity, acting on acetyl-CoA as donor”
L-glutamate N-acetyltransferase activity, acting on acetyl-CoA as donor term tracker item “https://github.com/geneontology/go-ontology/issues/31438”^^anyURI

L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor `http://purl.obolibrary.org/obo/GO_0004358`

Removed

L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor has_related_synonym “acetylglutamate synthetase activity”
- database_cross_reference “EC:2.3.1.35”
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor has_related_synonym “2-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity”
- database_cross_reference “EC:2.3.1.35”
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor has_related_synonym “acetylornithine glutamate acetyltransferase activity”
- database_cross_reference “EC:2.3.1.35”
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor has_related_synonym “acetylglutamic synthetase activity”
- database_cross_reference “EC:2.3.1.35”
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor has_related_synonym “ornithine transacetylase activity”
- database_cross_reference “EC:2.3.1.35”
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor has_related_synonym “acetylglutamate-acetylornithine transacetylase activity”
- database_cross_reference “EC:2.3.1.35”
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor has_related_synonym “glutamate acetyltransferase activity”
- database_cross_reference “EC:2.3.1.35”
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor has_related_synonym “alpha-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity”
- database_cross_reference “EC:2.3.1.35”
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor has_related_synonym “ornithine acetyltransferase activity”
- database_cross_reference “EC:2.3.1.35”
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor has_related_synonym “N2-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity”
- database_cross_reference “EC:2.3.1.35”
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor has_related_synonym “acetylglutamic-acetylornithine transacetylase activity”
- database_cross_reference “EC:2.3.1.35”

Added

L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor has_exact_synonym “N2-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity”
- database_cross_reference “EC:2.3.1.35”
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor has_exact_synonym “2-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity”
- database_cross_reference “EC:2.3.1.35”
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor has_exact_synonym “acetylglutamic-acetylornithine transacetylase activity”
- database_cross_reference “EC:2.3.1.35”
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor has_broad_synonym “ornithine acetyltransferase activity”
- database_cross_reference “EC:2.3.1.35”
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor has_broad_synonym “glutamate acetyltransferase activity”
- database_cross_reference “EC:2.3.1.35”
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor has_exact_synonym “alpha-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity”
- database_cross_reference “EC:2.3.1.35”
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor has_exact_synonym “acetylornithine glutamate acetyltransferase activity”
- database_cross_reference “EC:2.3.1.35”
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor has_exact_synonym “acetylglutamate-acetylornithine transacetylase activity”
- database_cross_reference “EC:2.3.1.35”
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor has_broad_synonym “ornithine transacetylase activity”
- database_cross_reference “EC:2.3.1.35”
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor has_broad_synonym “acetylglutamate synthetase activity”
- database_cross_reference “EC:2.3.1.35”
L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor has_broad_synonym “acetylglutamic synthetase activity”
- database_cross_reference “EC:2.3.1.35”

L-glutamate biosynthetic process `http://purl.obolibrary.org/obo/GO_0097054`

Added

L-glutamate biosynthetic process database_cross_reference “MetaCyc:GLUTAMATE-SYN2-PWY”
L-glutamate biosynthetic process narrowMatch GLUGLNSYN-PWY
L-glutamate biosynthetic process database_cross_reference “MetaCyc:PWY-4341”
L-glutamate biosynthetic process database_cross_reference “MetaCyc:GLUTSYNIII-PWY”
L-glutamate biosynthetic process narrowMatch GLUTSYN-PWY
L-glutamate biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
L-glutamate biosynthetic process narrowMatch GLUTAMATE-SYN2-PWY
L-glutamate biosynthetic process database_cross_reference “MetaCyc:GLUTSYN-PWY”
L-glutamate biosynthetic process database_cross_reference “MetaCyc:GLUGLNSYN-PWY”
L-glutamate biosynthetic process narrowMatch GLUTSYNIII-PWY
L-glutamate biosynthetic process narrowMatch PWY-4341

L-glutamate catabolic process `http://purl.obolibrary.org/obo/GO_0006538`

Removed

L-glutamate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-glutamate, the anion of 2-aminopentanedioic acid.”
- database_cross_reference “GOC:go_curators”

Added

L-glutamate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-glutamate.”
- database_cross_reference “GOC:curators”
L-glutamate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI

L-glutamate dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0004352`

Removed

L-glutamate dehydrogenase (NAD+) activity relatedMatch GLUTAMATE-DEG1-PWY
L-glutamate dehydrogenase (NAD+) activity comment “Note that this term has a MetaCyc pathway reference as the pathway only has a single step.”

Added

L-glutamate dehydrogenase (NAD+) activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI

L-glutamate dehydrogenase (NADP+) activity `http://purl.obolibrary.org/obo/GO_0004354`

Removed

L-glutamate dehydrogenase (NADP+) activity relatedMatch GLUTSYNIII-PWY
L-glutamate dehydrogenase (NADP+) activity comment “Note that this term has a MetaCyc pathway reference as the pathway only has a single step.”

Added

L-glutamate dehydrogenase (NADP+) activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI

L-glutamate dehydrogenase [NAD(P)+] activity `http://purl.obolibrary.org/obo/GO_0004353`

Removed

L-glutamate dehydrogenase [NAD(P)+] activity database_cross_reference “Reactome:R-HSA-70589”
- label “alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]”
L-glutamate dehydrogenase [NAD(P)+] activity comment “Note that this term has a MetaCyc pathway reference as the pathway only has a single step.”
L-glutamate dehydrogenase [NAD(P)+] activity relatedMatch GLUTAMATE-SYN2-PWY
L-glutamate dehydrogenase [NAD(P)+] activity relatedMatch PWY-5766
L-glutamate dehydrogenase [NAD(P)+] activity database_cross_reference “Reactome:R-HSA-70600”
- label “glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]”

Added

L-glutamate dehydrogenase [NAD(P)+] activity database_cross_reference “Reactome:R-HSA-70600”
- label “glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2)”
L-glutamate dehydrogenase [NAD(P)+] activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI
L-glutamate dehydrogenase [NAD(P)+] activity database_cross_reference “Reactome:R-HSA-70589”
- label “alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2)”

L-glutamate fermentation `http://purl.obolibrary.org/obo/GO_0033508`

Removed

L-glutamate fermentation label “L-glutamate catabolic process to pyruvate”
L-glutamate fermentation definition “The chemical reactions and pathways resulting in the breakdown of L-glutamate into pyruvate.”
- database_cross_reference “MetaCyc:PWY-5087”

Added

L-glutamate fermentation database_cross_reference “MetaCyc:PWY-5088”
L-glutamate fermentation narrowMatch P162-PWY
L-glutamate fermentation label “L-glutamate fermentation”
L-glutamate fermentation has_narrow_synonym “L-glutamate fermentation to propionate”
L-glutamate fermentation narrowMatch PWY-8190
L-glutamate fermentation has_narrow_synonym “L-glutamate catabolic process to pyruvate”
L-glutamate fermentation narrowMatch PWY-5088
L-glutamate fermentation has_narrow_synonym “L-glutamate fermentation via L-citramalate”
L-glutamate fermentation database_cross_reference “MetaCyc:P162-PWY”
L-glutamate fermentation narrowMatch PWY-5087
L-glutamate fermentation definition “The anaerobic chemical reactions and pathways resulting in the breakdown of L-glutamate, yielding energy in the form of ATP.”
- database_cross_reference “PMID:38821505”
L-glutamate fermentation database_cross_reference “MetaCyc:PWY-8190”
L-glutamate fermentation narrowMatch GLUDEG-II-PWY
L-glutamate fermentation has_narrow_synonym “L-glutamate fermentation via 2-hydroxyglutarate”
L-glutamate fermentation database_cross_reference “MetaCyc:GLUDEG-II-PWY”
L-glutamate fermentation has_narrow_synonym “L-glutamate fermentation to pyruvate”

L-glutamate gamma-semialdehyde dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0003842`

Removed

L-glutamate gamma-semialdehyde dehydrogenase activity database_cross_reference “Reactome:R-HSA-6784399”
- label “ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate”

Added

L-glutamate gamma-semialdehyde dehydrogenase activity database_cross_reference “Reactome:R-HSA-9929439”
- label “ALDH4A1 oxidizes 1PYR-3OH-5COOH”
L-glutamate gamma-semialdehyde dehydrogenase activity database_cross_reference “Reactome:R-HSA-6784402”
- label “ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate”

L-glutamate import into mitochondrion `http://purl.obolibrary.org/obo/GO_0110141`

Added

L-glutamate import into mitochondrion SubClassOf intercellular transport

L-glutamate oxidase activity `http://purl.obolibrary.org/obo/GO_0050025`

Removed

L-glutamate oxidase activity definition “Catalysis of the reaction: L-glutamate + O2 + H2O = 2-oxoglutarate + NH3 + H2O2.”
- database_cross_reference “RHEA:20728”

Added

L-glutamate oxidase activity definition “Catalysis of the reaction: L-glutamate + O2 + H2O = 2-oxoglutarate + H2O2 + NH4+.”
- database_cross_reference “RHEA:20728”

L-glutamate:prephenate transaminase activity `http://purl.obolibrary.org/obo/GO_0033854`

Removed

L-glutamate:prephenate transaminase activity label “glutamate-prephenate aminotransferase activity”
L-glutamate:prephenate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + L-arogenate = L-glutamate + prephenate.”
- database_cross_reference “RHEA:22880”
- database_cross_reference “EC:2.6.1.79”
L-glutamate:prephenate transaminase activity SubClassOf transaminase activity

Added

L-glutamate:prephenate transaminase activity has_exact_synonym “glutamate-prephenate aminotransferase activity”
L-glutamate:prephenate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + L-arogenate = L-glutamate + prephenate.”
- database_cross_reference “RHEA:22880”
L-glutamate:prephenate transaminase activity label “L-glutamate:prephenate transaminase activity”
L-glutamate:prephenate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-glutamate:prephenate transaminase activity SubClassOf amino acid transaminase activity

L-glutamine N-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0047946`

Removed

L-glutamine N-acyltransferase activity label “glutamine N-acyltransferase activity”
L-glutamine N-acyltransferase activity definition “Catalysis of the reaction: acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine.”
- database_cross_reference “MetaCyc:GLUTAMINE-N-ACYLTRANSFERASE-RXN”
- database_cross_reference “EC:2.3.1.68”
L-glutamine N-acyltransferase activity SubClassOf N-acyltransferase activity

Added

L-glutamine N-acyltransferase activity label “L-glutamine N-acyltransferase activity”
L-glutamine N-acyltransferase activity has_broad_synonym “glutamine N-acyltransferase activity”
L-glutamine N-acyltransferase activity definition “Catalysis of the reaction: acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine.”
- database_cross_reference “RHEA:18469”
L-glutamine N-acyltransferase activity SubClassOf L-amino-acid N-acetyltransferase activity

L-glutamine biosynthetic process `http://purl.obolibrary.org/obo/GO_1901704`

Added

L-glutamine biosynthetic process database_cross_reference “MetaCyc:GLNSYN-PWY”
L-glutamine biosynthetic process narrowMatch GLNSYN-PWY
L-glutamine biosynthetic process broadMatch PWY-5505
L-glutamine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI

L-glutamine catabolic process `http://purl.obolibrary.org/obo/GO_0006543`

Removed

L-glutamine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-glutamine, 2-amino-4-carbamoylbutanoic acid.”
- database_cross_reference “GOC:ai”

Added

L-glutamine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-glutamine.”
- database_cross_reference “GOC:curators”
L-glutamine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI

L-glutamine family amino acid biosynthetic process `http://purl.obolibrary.org/obo/GO_0009084`

Removed

L-glutamine family amino acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.”
- database_cross_reference “GOC:ai”
- database_cross_reference “MetaCyc:GLUTAMINE-SYN”
L-glutamine family amino acid biosynthetic process exactMatch GLUTAMINE-SYN
L-glutamine family amino acid biosynthetic process database_cross_reference “MetaCyc:GLUTAMINE-SYN”

Added

L-glutamine family amino acid biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
L-glutamine family amino acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.”
- database_cross_reference “GOC:ai”

L-glutamine import across plasma membrane `http://purl.obolibrary.org/obo/GO_1903803`

Removed

L-glutamine import across plasma membrane SubClassOf organic cation transport

L-glutamine metabolic process `http://purl.obolibrary.org/obo/GO_0006541`

Removed

L-glutamine metabolic process label “glutamine metabolic process”
L-glutamine metabolic process SubClassOf carboxylic acid metabolic process

Added

L-glutamine metabolic process label “L-glutamine metabolic process”
L-glutamine metabolic process SubClassOf L-amino acid metabolic process
L-glutamine metabolic process SubClassOf proteinogenic amino acid metabolic process

L-glutamine secretion `http://purl.obolibrary.org/obo/GO_0010585`

Removed

L-glutamine secretion label “glutamine secretion”

Added

L-glutamine secretion has_exact_synonym “glutamine secretion”
L-glutamine secretion term tracker item “https://github.com/geneontology/go-ontology/issues/27059”^^anyURI
L-glutamine secretion label “L-glutamine secretion”

L-glutamine transport `http://purl.obolibrary.org/obo/GO_0006868`

Removed

L-glutamine transport has_narrow_synonym “L-glutamine transport”
L-glutamine transport label “glutamine transport”
L-glutamine transport SubClassOf nitrogen compound transport
L-glutamine transport SubClassOf carboxylic acid transport

Added

L-glutamine transport term tracker item “https://github.com/geneontology/go-ontology/issues/27059”^^anyURI
L-glutamine transport has_broad_synonym “glutamine transport”
L-glutamine transport label “L-glutamine transport”
L-glutamine transport SubClassOf L-amino acid transport
L-glutamine transport SubClassOf organic cation transport

L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity `http://purl.obolibrary.org/obo/GO_0004360`

Removed

L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity label “glutamine-fructose-6-phosphate transaminase (isomerizing) activity”
L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity definition “Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate.”
- database_cross_reference “EC:2.6.1.16”
- database_cross_reference “RHEA:13237”
L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity SubClassOf obsolete L-glutamine transaminase activity

Added

L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity label “L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity”
L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity definition “Catalysis of the reaction: D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate.”
- database_cross_reference “RHEA:13237”
L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity has_exact_synonym “glutamine-fructose-6-phosphate transaminase (isomerizing) activity”
L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity SubClassOf amino acid transaminase activity

L-glutamine:phenylpyruvate transaminase activity `http://purl.obolibrary.org/obo/GO_0047316`

Removed

L-glutamine:phenylpyruvate transaminase activity label “glutamine-phenylpyruvate transaminase activity”
L-glutamine:phenylpyruvate transaminase activity definition “Catalysis of the reaction: keto-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine.”
- database_cross_reference “RHEA:17593”
- database_cross_reference “EC:2.6.1.64”
L-glutamine:phenylpyruvate transaminase activity SubClassOf obsolete L-glutamine transaminase activity

Added

L-glutamine:phenylpyruvate transaminase activity definition “Catalysis of the reaction: 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine.”
- database_cross_reference “RHEA:17593”
L-glutamine:phenylpyruvate transaminase activity has_exact_synonym “glutamine-phenylpyruvate transaminase activity”
L-glutamine:phenylpyruvate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-glutamine:phenylpyruvate transaminase activity label “L-glutamine:phenylpyruvate transaminase activity”
L-glutamine:phenylpyruvate transaminase activity SubClassOf amino acid transaminase activity

L-glutamine:pyruvate transaminase activity `http://purl.obolibrary.org/obo/GO_0047945`

Removed

L-glutamine:pyruvate transaminase activity definition “Catalysis of the reaction: L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine.”
- database_cross_reference “EC:2.6.1.15”
- database_cross_reference “RHEA:10400”
L-glutamine:pyruvate transaminase activity label “L-glutamine:pyruvate aminotransferase activity”
L-glutamine:pyruvate transaminase activity SubClassOf obsolete L-glutamine transaminase activity

Added

L-glutamine:pyruvate transaminase activity label “L-glutamine:pyruvate transaminase activity”
L-glutamine:pyruvate transaminase activity definition “Catalysis of the reaction: L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine.”
- database_cross_reference “RHEA:10400”
L-glutamine:pyruvate transaminase activity has_exact_synonym “L-glutamine:pyruvate aminotransferase activity”
L-glutamine:pyruvate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-glutamine:pyruvate transaminase activity SubClassOf L-alanine:oxo-acid transaminase activity

L-glutamine:scyllo-inositol transaminase activity `http://purl.obolibrary.org/obo/GO_0047310`

Removed

L-glutamine:scyllo-inositol transaminase activity label “glutamine-scyllo-inositol transaminase activity”
L-glutamine:scyllo-inositol transaminase activity definition “Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone + L-glutamine = 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate.”
- database_cross_reference “EC:2.6.1.50”
- database_cross_reference “RHEA:22920”
L-glutamine:scyllo-inositol transaminase activity SubClassOf obsolete L-glutamine transaminase activity

Added

L-glutamine:scyllo-inositol transaminase activity label “L-glutamine:scyllo-inositol transaminase activity”
L-glutamine:scyllo-inositol transaminase activity definition “Catalysis of the reaction: scyllo-inosose + L-glutamine = 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate.”
- database_cross_reference “RHEA:22920”
L-glutamine:scyllo-inositol transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-glutamine:scyllo-inositol transaminase activity has_exact_synonym “glutamine-scyllo-inositol transaminase activity”
L-glutamine:scyllo-inositol transaminase activity SubClassOf amino acid transaminase activity

L-histidine N-acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0047981`

Removed

L-histidine N-acetyltransferase activity definition “Catalysis of the reaction: L-histidine + acetyl-CoA = N(alpha)-acetyl-L-histidine + CoA + H+.”
- database_cross_reference “EC:2.3.1.33”
- database_cross_reference “RHEA:24596”

Added

L-histidine N-acetyltransferase activity definition “Catalysis of the reaction: L-histidine + acetyl-CoA = N(alpha)-acetyl-L-histidine + CoA + H+.”
- database_cross_reference “RHEA:24596”

L-histidine biosynthetic process `http://purl.obolibrary.org/obo/GO_0000105`

Removed

L-histidine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.”
- database_cross_reference “GOC:go_curators”
L-histidine biosynthetic process SubClassOf obsolete L-histidine metabolic process

Added

L-histidine biosynthetic process database_cross_reference “MetaCyc:PWY-5029”
L-histidine biosynthetic process narrowMatch PWY-5029
L-histidine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.”
- database_cross_reference “GOC:curators”
L-histidine biosynthetic process narrowMatch HISTSYN-PWY
L-histidine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
L-histidine biosynthetic process SubClassOf imidazole-containing compound metabolic process

L-histidine catabolic process `http://purl.obolibrary.org/obo/GO_0006548`

Removed

L-histidine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.”
- database_cross_reference “GOC:go_curators”
L-histidine catabolic process SubClassOf obsolete L-histidine metabolic process

Added

L-histidine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI
L-histidine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-histidine.”
- database_cross_reference “GOC:curators”

L-histidine:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0008110`

Removed

L-histidine:2-oxoglutarate transaminase activity label “L-histidine:2-oxoglutarate aminotransferase activity”
L-histidine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + L-histidine = 3-(imidazol-5-yl)pyruvate + L-glutamate.”
- database_cross_reference “EC:2.6.1.38”
- database_cross_reference “RHEA:16565”
L-histidine:2-oxoglutarate transaminase activity SubClassOf transaminase activity

Added

L-histidine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: L-histidine + 2-oxoglutarate = 3-(imidazol-5-yl)pyruvate + L-glutamate.”
- database_cross_reference “RHEA:16565”
L-histidine:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-histidine:2-oxoglutarate transaminase activity has_exact_synonym “L-histidine:2-oxoglutarate aminotransferase activity”
L-histidine:2-oxoglutarate transaminase activity label “L-histidine:2-oxoglutarate transaminase activity”
L-histidine:2-oxoglutarate transaminase activity SubClassOf amino acid transaminase activity

L-histidinol-phosphate:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0004400`

Removed

L-histidinol-phosphate:2-oxoglutarate transaminase activity label “histidinol-phosphate transaminase activity”
L-histidinol-phosphate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.”
- database_cross_reference “EC:2.6.1.9”
L-histidinol-phosphate:2-oxoglutarate transaminase activity SubClassOf transaminase activity

Added

L-histidinol-phosphate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.”
- database_cross_reference “RHEA:23744”
L-histidinol-phosphate:2-oxoglutarate transaminase activity label “L-histidinol-phosphate:2-oxoglutarate transaminase activity”
L-histidinol-phosphate:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-histidinol-phosphate:2-oxoglutarate transaminase activity has_exact_synonym “histidinol-phosphate transaminase activity”
L-histidinol-phosphate:2-oxoglutarate transaminase activity SubClassOf amino acid transaminase activity

L-homocysteine biosynthetic process `http://purl.obolibrary.org/obo/GO_0071269`

Removed

L-homocysteine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of L-homocysteine, the L-enantiomer of 2-amino-4-sulfanylbutanoic acid.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:ecd”

Added

L-homocysteine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of L-homocysteine.”
- database_cross_reference “GOC:curators”
L-homocysteine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31510”^^anyURI
L-homocysteine biosynthetic process database_cross_reference “MetaCyc:PWY-5344”

L-homoserine biosynthetic process `http://purl.obolibrary.org/obo/GO_0009090`

Removed

L-homoserine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of homoserine, alpha-amino-gamma-hydroxybutyric acid.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “MetaCyc:HOMOSERSYN-PWY”
- database_cross_reference “ISBN:0198506732”

Added

L-homoserine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of homoserine, alpha-amino-gamma-hydroxybutyric acid.”
- database_cross_reference “GOC:curators”
- database_cross_reference “MetaCyc:HOMOSERSYN-PWY”
- database_cross_reference “ISBN:0198506732”

L-homoserine transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0042970`

Removed

L-homoserine transmembrane transporter activity definition “Enables the transfer of homoserine from one side of a membrane to the other. Homoserine is alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

L-homoserine transmembrane transporter activity definition “Enables the transfer of homoserine from one side of a membrane to the other. Homoserine is alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

L-iduronidase activity `http://purl.obolibrary.org/obo/GO_0003940`

Removed

L-iduronidase activity database_cross_reference “Reactome:R-HSA-1793186”
- label “IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS”
L-iduronidase activity database_cross_reference “Reactome:R-HSA-1678716”
- label “IDUA hydrolyses Heparan sulfate chain(1)”

Added

L-iduronidase activity database_cross_reference “Reactome:R-HSA-1678716”
- label “IDUA cleaves iduronate from HS chain”
L-iduronidase activity database_cross_reference “Reactome:R-HSA-1793186”
- label “IDUA hydrolyses the unsulfated alpha-L-iduronosidic link in DS”

L-isoleucine biosynthetic process `http://purl.obolibrary.org/obo/GO_1901705`

Removed

L-isoleucine biosynthetic process SubClassOf obsolete isoleucine biosynthetic process

Added

L-isoleucine biosynthetic process narrowMatch PWY-5103
L-isoleucine biosynthetic process narrowMatch ILEUSYN-PWY
L-isoleucine biosynthetic process database_cross_reference “MetaCyc:PWY-5104”
L-isoleucine biosynthetic process narrowMatch PWY-5104
L-isoleucine biosynthetic process database_cross_reference “MetaCyc:ILEUSYN-PWY”
L-isoleucine biosynthetic process narrowMatch PWY-5108
L-isoleucine biosynthetic process database_cross_reference “MetaCyc:PWY-5108”
L-isoleucine biosynthetic process database_cross_reference “MetaCyc:PWY-5101”
L-isoleucine biosynthetic process narrowMatch PWY-5101
L-isoleucine biosynthetic process database_cross_reference “MetaCyc:PWY-5103”
L-isoleucine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/30848”^^anyURI
L-isoleucine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
L-isoleucine biosynthetic process SubClassOf branched-chain amino acid biosynthetic process
L-isoleucine biosynthetic process SubClassOf isoleucine metabolic process

L-isoleucine catabolic process `http://purl.obolibrary.org/obo/GO_0006550`

Removed

L-isoleucine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-isoleucine, (2R,3R)-2-amino-3-methylpentanoic acid.”
- database_cross_reference “GOC:ai”

Added

L-isoleucine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-isoleucine.”
- database_cross_reference “GOC:curators”
L-isoleucine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI

L-isoleucine:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0052656`

Removed

L-isoleucine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid.”
- database_cross_reference “RHEA:24801”
L-isoleucine:2-oxoglutarate transaminase activity label “L-isoleucine-2-oxoglutarate transaminase activity”

Added

L-isoleucine:2-oxoglutarate transaminase activity label “L-isoleucine:2-oxoglutarate transaminase activity”
L-isoleucine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate.”
- database_cross_reference “RHEA:24801”
L-isoleucine:2-oxoglutarate transaminase activity has_exact_synonym “L-isoleucine-2-oxoglutarate transaminase activity”

L-kynurenine catabolic process `http://purl.obolibrary.org/obo/GO_0097053`

Removed

L-kynurenine catabolic process SubClassOf obsolete L-kynurenine metabolic process

Added

L-kynurenine catabolic process SubClassOf kynurenine metabolic process

L-kynurenine:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0016212`

Removed

L-kynurenine:2-oxoglutarate transaminase activity label “kynurenine-oxoglutarate transaminase activity”
L-kynurenine:2-oxoglutarate transaminase activity database_cross_reference “Reactome:R-HSA-893596”
- label “PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu”
L-kynurenine:2-oxoglutarate transaminase activity database_cross_reference “Reactome:R-HSA-901097”
- label “kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL2]”

Added

L-kynurenine:2-oxoglutarate transaminase activity has_exact_synonym “kynurenine-oxoglutarate transaminase activity”
L-kynurenine:2-oxoglutarate transaminase activity label “L-kynurenine:2-oxoglutarate transaminase activity”
L-kynurenine:2-oxoglutarate transaminase activity database_cross_reference “Reactome:R-HSA-901097”
- label “PXLP-KYAT3 (CCBL2) dimer transaminates L-KYN to KYNA”
L-kynurenine:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-kynurenine:2-oxoglutarate transaminase activity database_cross_reference “Reactome:R-HSA-893596”
- label “PXLP-KYAT1 dimer transaminates L-KYN to KYNA”

L-kynurenine:glyoxylate transaminase activity `http://purl.obolibrary.org/obo/GO_0047315`

Removed

L-kynurenine:glyoxylate transaminase activity label “kynurenine-glyoxylate transaminase activity”
L-kynurenine:glyoxylate transaminase activity definition “Catalysis of the reaction: L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine.”
- database_cross_reference “EC:2.6.1.63”
- database_cross_reference “RHEA:19249”

Added

L-kynurenine:glyoxylate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-kynurenine:glyoxylate transaminase activity definition “Catalysis of the reaction: L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine.”
- database_cross_reference “RHEA:19249”
L-kynurenine:glyoxylate transaminase activity label “L-kynurenine:glyoxylate transaminase activity”
L-kynurenine:glyoxylate transaminase activity has_exact_synonym “kynurenine-glyoxylate transaminase activity”

L-leucine N-acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0050050`

Removed

L-leucine N-acetyltransferase activity definition “Catalysis of the reaction: L-leucine + acetyl-CoA = N-acetyl-L-leucine + CoA + H+.”
- database_cross_reference “RHEA:20089”
- database_cross_reference “EC:2.3.1.66”

Added

L-leucine N-acetyltransferase activity definition “Catalysis of the reaction: L-leucine + acetyl-CoA = N-acetyl-L-leucine + CoA + H+.”
- database_cross_reference “RHEA:20089”

L-leucine catabolic process `http://purl.obolibrary.org/obo/GO_0006552`

Removed

L-leucine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-leucine, 2-amino-4-methylpentanoic acid.”
- database_cross_reference “GOC:ai”

Added

L-leucine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI
L-leucine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-leucine.”
- database_cross_reference “GOC:curators”

L-leucine:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0052654`

Removed

L-leucine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamatic acid.”
- database_cross_reference “RHEA:18321”
L-leucine:2-oxoglutarate transaminase activity label “L-leucine-2-oxoglutarate transaminase activity”

Added

L-leucine:2-oxoglutarate transaminase activity has_exact_synonym “L-leucine-2-oxoglutarate transaminase activity”
L-leucine:2-oxoglutarate transaminase activity label “L-leucine:2-oxoglutarate transaminase activity”
L-leucine:2-oxoglutarate transaminase activity exactMatch 2.6.1.6
L-leucine:2-oxoglutarate transaminase activity database_cross_reference “EC:2.6.1.6”
L-leucine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction:L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.”
- database_cross_reference “RHEA:18321”
L-leucine:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI

L-lysine 6-dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0050303`

Removed

L-lysine 6-dehydrogenase activity relatedMatch 64800
L-lysine 6-dehydrogenase activity relatedMatch 64792
L-lysine 6-dehydrogenase activity definition “Catalysis of the reaction: L-lysine + NAD+ = L-1-piperideine-6-carboxylate + NH4+ + NADH + 2 H+.”
- database_cross_reference “RHEA:12408”
L-lysine 6-dehydrogenase activity exactMatch 12408
L-lysine 6-dehydrogenase activity relatedMatch PWY-5314
L-lysine 6-dehydrogenase activity comment “Note that this term has a MetaCyc pathway reference as the pathway only has a single step.”
L-lysine 6-dehydrogenase activity exactMatch LYSINE-6-DEHYDROGENASE-RXN

Added

L-lysine 6-dehydrogenase activity database_cross_reference “RHEA:64792”
L-lysine 6-dehydrogenase activity narrowMatch LYSINE-6-DEHYDROGENASE-RXN
L-lysine 6-dehydrogenase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI
L-lysine 6-dehydrogenase activity database_cross_reference “RHEA:64800”
L-lysine 6-dehydrogenase activity narrowMatch 64792
L-lysine 6-dehydrogenase activity narrowMatch 12408
L-lysine 6-dehydrogenase activity definition “Catalysis of the reaction: L-lysine + NAD+ = L-1-piperideine-6-carboxylate + NH4+ + NADH + 2 H+. (S)-(2-aminoethyl)-L-cysteine can act as a substrate, and NADP+ can act as the acceptor.”
- database_cross_reference “EC:1.4.1.18”
L-lysine 6-dehydrogenase activity narrowMatch 64800
L-lysine 6-dehydrogenase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31730”^^anyURI

L-lysine N6-acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0090595`

Removed

L-lysine N6-acetyltransferase activity definition “Catalysis of the reaction: acetyl-CoA + L-lysine = CoA + H+ + N(6)-acetyl-L-lysine.”
- database_cross_reference “RHEA:69476”

Added

L-lysine N6-acetyltransferase activity definition “Catalysis of the reaction: acetyl-CoA + L-lysine = CoA + H+ + N6-acetyl-L-lysine.”
- database_cross_reference “RHEA:69476”

L-lysine N6-acetyltransferase activity, acting on acetyl phosphate as donor `http://purl.obolibrary.org/obo/GO_0004468`

Removed

L-lysine N6-acetyltransferase activity, acting on acetyl phosphate as donor label “L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor”

Added

L-lysine N6-acetyltransferase activity, acting on acetyl phosphate as donor label “L-lysine N6-acetyltransferase activity, acting on acetyl phosphate as donor”

L-lysine biosynthetic process `http://purl.obolibrary.org/obo/GO_0009085`

Removed

L-lysine biosynthetic process database_cross_reference “MetaCyc:LYSINE-SYN”
L-lysine biosynthetic process exactMatch LYSINE-SYN
L-lysine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of L-lysine, 2,6-diaminohexanoic acid.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “MetaCyc:LYSINE-SYN”
L-lysine biosynthetic process SubClassOf obsolete lysine metabolic process

Added

L-lysine biosynthetic process narrowMatch DAPLYSINESYN-PWY
L-lysine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
L-lysine biosynthetic process database_cross_reference “MetaCyc:PWY-3081”
L-lysine biosynthetic process database_cross_reference “MetaCyc:PWY-2941”
L-lysine biosynthetic process narrowMatch LYSINE-AMINOAD-PWY
L-lysine biosynthetic process database_cross_reference “MetaCyc:PWY-5097”
L-lysine biosynthetic process narrowMatch PWY-2942
L-lysine biosynthetic process narrowMatch PWY-2941
L-lysine biosynthetic process database_cross_reference “MetaCyc:LYSINE-AMINOAD-PWY”
L-lysine biosynthetic process narrowMatch PWY-3081
L-lysine biosynthetic process database_cross_reference “MetaCyc:DAPLYSINESYN-PWY”
L-lysine biosynthetic process narrowMatch PWY-5097
L-lysine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of L-lysine, 2,6-diaminohexanoic acid.”
- database_cross_reference “GOC:curators”
L-lysine biosynthetic process database_cross_reference “MetaCyc:PWY-2942”

L-lysine catabolic process `http://purl.obolibrary.org/obo/GO_0019477`

Removed

L-lysine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-lysine, the L-enantiomer of (S)-2,6-diaminohexanoic acid.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:jsg”
L-lysine catabolic process SubClassOf obsolete lysine metabolic process

Added

L-lysine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI
L-lysine catabolic process narrowMatch PWY-5324
L-lysine catabolic process database_cross_reference “MetaCyc:PWY-5311”
L-lysine catabolic process database_cross_reference “MetaCyc:PWY-5324”
L-lysine catabolic process database_cross_reference “MetaCyc:PWY-5314”
L-lysine catabolic process narrowMatch PWY-5314
L-lysine catabolic process narrowMatch PWY-5311
L-lysine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI
L-lysine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-lysine.”
- database_cross_reference “GOC:curators”

L-lysine oxidase activity `http://purl.obolibrary.org/obo/GO_0050029`

Removed

L-lysine oxidase activity relatedMatch PWY-5311
L-lysine oxidase activity comment “Note that this term has a MetaCyc pathway reference as the pathway only has a single step.”

Added

L-lysine oxidase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI

L-lysine:2-oxoglutarate 6-transaminase activity `http://purl.obolibrary.org/obo/GO_0045484`

Removed

L-lysine:2-oxoglutarate 6-transaminase activity label “L-lysine 6-transaminase activity”
L-lysine:2-oxoglutarate 6-transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + L-lysine = L-glutamate + allysine.”
- database_cross_reference “EC:2.6.1.36”
- database_cross_reference “RHEA:21200”
L-lysine:2-oxoglutarate 6-transaminase activity SubClassOf transaminase activity

Added

L-lysine:2-oxoglutarate 6-transaminase activity label “L-lysine:2-oxoglutarate 6-transaminase activity”
L-lysine:2-oxoglutarate 6-transaminase activity has_exact_synonym “L-lysine 6-transaminase activity”
L-lysine:2-oxoglutarate 6-transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-lysine:2-oxoglutarate 6-transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + L-lysine = L-glutamate + allysine.”
- database_cross_reference “RHEA:21200”
L-lysine:2-oxoglutarate 6-transaminase activity SubClassOf amino acid transaminase activity

L-lysine:pyruvate 6-transaminase activity `http://purl.obolibrary.org/obo/GO_0050065`

Removed

L-lysine:pyruvate 6-transaminase activity label “lysine-pyruvate 6-transaminase activity”
L-lysine:pyruvate 6-transaminase activity comment “Note that this term has a MetaCyc pathway reference as the pathway only has a single step.”
L-lysine:pyruvate 6-transaminase activity definition “Catalysis of the reaction: L-lysine + pyruvate = L-alanine + L-allysine.”
- database_cross_reference “RHEA:19393”
- database_cross_reference “EC:2.6.1.71”
L-lysine:pyruvate 6-transaminase activity relatedMatch PWY-5324
L-lysine:pyruvate 6-transaminase activity SubClassOf transaminase activity

Added

L-lysine:pyruvate 6-transaminase activity definition “Catalysis of the reaction: L-lysine + pyruvate = (S)-2-amino-6-oxohexanoate + L-alanine.”
- database_cross_reference “RHEA:19393”
L-lysine:pyruvate 6-transaminase activity has_exact_synonym “lysine-pyruvate 6-transaminase activity”
L-lysine:pyruvate 6-transaminase activity label “L-lysine:pyruvate 6-transaminase activity”
L-lysine:pyruvate 6-transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-lysine:pyruvate 6-transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI
L-lysine:pyruvate 6-transaminase activity SubClassOf amino acid transaminase activity

L-lysine:pyruvate alpha-transaminase activity `http://purl.obolibrary.org/obo/GO_0062045`

Removed

L-lysine:pyruvate alpha-transaminase activity label “L-lysine alpha-aminotransferase activity”
L-lysine:pyruvate alpha-transaminase activity SubClassOf transaminase activity

Added

L-lysine:pyruvate alpha-transaminase activity label “L-lysine:pyruvate alpha-transaminase activity”
L-lysine:pyruvate alpha-transaminase activity has_broad_synonym “L-lysine alpha-aminotransferase activity”
L-lysine:pyruvate alpha-transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-lysine:pyruvate alpha-transaminase activity SubClassOf amino acid transaminase activity

L-malate catabolic process `http://purl.obolibrary.org/obo/GO_0043464`

Removed

L-malate catabolic process label “malolactic fermentation”
L-malate catabolic process comment “Despite the name, this is not an ATP-generating fermentation process. See MetaCyc:PWY-7685.”
L-malate catabolic process definition “The chemical reactions and pathways involving the enzymatic conversion of L-malate to L-lactate and carbon dioxide.”
- database_cross_reference “PMID:8808948”
- database_cross_reference “PMID:10427020”
L-malate catabolic process SubClassOf has part some malolactic enzyme activity

Added

L-malate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
L-malate catabolic process has_exact_synonym “malolactic fermentation”
L-malate catabolic process comment “Despite the synonym ‘malolactic fermentation’, this is not an ATP-generating fermentation process. See MetaCyc:PWY-7685.”
L-malate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-malate.”
- database_cross_reference “PMID:8808948”
- database_cross_reference “PMID:10427020”
L-malate catabolic process narrowMatch PWY-7686
L-malate catabolic process label “L-malate catabolic process”
L-malate catabolic process narrowMatch PWY-7685
L-malate catabolic process database_cross_reference “MetaCyc:PWY-7686”
L-malate catabolic process SubClassOf dicarboxylic acid catabolic process

L-malate dehydrogenase (quinone) activity `http://purl.obolibrary.org/obo/GO_0008924`

Added

L-malate dehydrogenase (quinone) activity narrowMatch 29083
L-malate dehydrogenase (quinone) activity database_cross_reference “RHEA:29083”

L-methionine biosynthetic process `http://purl.obolibrary.org/obo/GO_0071265`

Added

L-methionine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI

L-methionine catabolic process `http://purl.obolibrary.org/obo/GO_0009087`

Removed

L-methionine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.”
- database_cross_reference “GOC:jl”
- database_cross_reference “ISBN:0198506732”

Added

L-methionine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-methionine.”
- database_cross_reference “GOC:curators”
L-methionine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI

L-methionine cycle `http://purl.obolibrary.org/obo/GO_0033353`

Removed

L-methionine cycle definition “A cyclic series of interconversions involving S-adenosylmethionine, S-adenosyl-L-homocysteine, L-cysteine, and L-methionine. Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of methionine.”
- database_cross_reference “GOC:mah”
- database_cross_reference “MetaCyc:PWY-5041”
L-methionine cycle label “S-adenosylmethionine cycle”
L-methionine cycle SubClassOf has part some S-adenosylmethionine-homocysteine S-methyltransferase activity

Added

L-methionine cycle definition “A cyclic series of interconversions involving S-adenosyl-L-homocysteine, L-homocysteine, L-methionine and S-adenosyl-L-methionine (SAM). Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of L-methionine.”
- database_cross_reference “PMID:31950558”
- database_cross_reference “PMID:39394448”
L-methionine cycle narrowMatch PWY-5041
L-methionine cycle term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
L-methionine cycle has_exact_synonym “S-adenosylmethionine cycle”
L-methionine cycle term tracker item “https://github.com/geneontology/go-ontology/issues/31318”^^anyURI
L-methionine cycle database_cross_reference “MetyaCyc:PWY-6151”
L-methionine cycle label “L-methionine cycle”

L-methionine metabolic process `http://purl.obolibrary.org/obo/GO_0006555`

Removed

L-methionine metabolic process label “methionine metabolic process”
L-methionine metabolic process definition “The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.”
- database_cross_reference “GOC:jl”
- database_cross_reference “ISBN:0198506732”
L-methionine metabolic process SubClassOf alpha-amino acid metabolic process

Added

L-methionine metabolic process label “L-methionine metabolic process”
L-methionine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31318”^^anyURI
L-methionine metabolic process definition “The chemical reactions and pathways involving L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.”
- database_cross_reference “GOC:jl”
- database_cross_reference “ISBN:0198506732”
L-methionine metabolic process SubClassOf proteinogenic amino acid metabolic process
L-methionine metabolic process SubClassOf L-amino acid metabolic process

L-methionine salvage `http://purl.obolibrary.org/obo/GO_0071267`

Added

L-methionine salvage narrowMatch PWY-8132
L-methionine salvage database_cross_reference “MetaCyc:PWY-4361”
L-methionine salvage narrowMatch PWY-7527
L-methionine salvage narrowMatch ADENOSYLHOMOCYSCAT-PWY
L-methionine salvage database_cross_reference “MetaCyc:PWY-7527”
L-methionine salvage database_cross_reference “MetaCyc:PWY-7270”
L-methionine salvage narrowMatch PWY-4361
L-methionine salvage database_cross_reference “MetaCyc:ADENOSYLHOMOCYSCAT-PWY”
L-methionine salvage has_narrow_synonym “L-methionine salvage cycle”
L-methionine salvage comment “For the ‘L-methionine cycle’ (aka the ‘S-adenosylmethionine cycle’), see GO:0033353.”
L-methionine salvage database_cross_reference “MetaCyc:PWY-8132”
L-methionine salvage database_cross_reference “MetaCyc:PWY-7528”
L-methionine salvage narrowMatch PWY-7270
L-methionine salvage narrowMatch PWY-7528
L-methionine salvage term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
L-methionine salvage database_cross_reference “MetaCyc:PWY-7174”
L-methionine salvage narrowMatch PWY-7174

L-methionine:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0080099`

Removed

L-methionine:2-oxoglutarate transaminase activity comment “This reaction falls within the larger set of reactions associated with EC:2.6.1.5 (See BRENDA: http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.5).”
L-methionine:2-oxoglutarate transaminase activity label “L-methionine:2-oxoglutarate aminotransferase activity”
L-methionine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: L-methionine + 2-oxoglutarate = 4-methylthio-2-oxobutyrate + L-glutamate.”
- database_cross_reference “PMID:18394996”

Added

L-methionine:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-methionine:2-oxoglutarate transaminase activity database_cross_reference “MetaCyc:RXN-14147”
L-methionine:2-oxoglutarate transaminase activity database_cross_reference “RHEA:25796”
L-methionine:2-oxoglutarate transaminase activity label “L-methionine:2-oxoglutarate transaminase activity”
L-methionine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: L-methionine + 2-oxoglutarate = 4-methylsulfanyl-2-oxobutanoate + L-glutamate.”
- database_cross_reference “PMID:18394996”
- database_cross_reference “RHEA:25796”
L-methionine:2-oxoglutarate transaminase activity has_exact_synonym “L-methionine:2-oxoglutarate aminotransferase activity”

L-methionine:glyoxylate transaminase activity `http://purl.obolibrary.org/obo/GO_0050094`

Removed

L-methionine:glyoxylate transaminase activity definition “Catalysis of the reaction: L-methionine + glyoxylate = 4-methylthio-2-oxobutanoate + glycine.”
- database_cross_reference “RHEA:22884”
- database_cross_reference “EC:2.6.1.73”
L-methionine:glyoxylate transaminase activity label “methionine-glyoxylate transaminase activity”
L-methionine:glyoxylate transaminase activity SubClassOf transaminase activity

Added

L-methionine:glyoxylate transaminase activity has_exact_synonym “methionine-glyoxylate transaminase activity”
L-methionine:glyoxylate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-methionine:glyoxylate transaminase activity definition “Catalysis of the reaction: glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine.”
- database_cross_reference “RHEA:22884”
L-methionine:glyoxylate transaminase activity label “L-methionine:glyoxylate transaminase activity”
L-methionine:glyoxylate transaminase activity SubClassOf L-methionine:oxo-acid transaminase activity

L-methionine:oxo-acid transaminase activity `http://purl.obolibrary.org/obo/GO_0010326`

Removed

L-methionine:oxo-acid transaminase activity label “methionine-oxo-acid transaminase activity”
L-methionine:oxo-acid transaminase activity SubClassOf transaminase activity

Added

L-methionine:oxo-acid transaminase activity has_exact_synonym “methionine-oxo-acid transaminase activity”
L-methionine:oxo-acid transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-methionine:oxo-acid transaminase activity label “L-methionine:oxo-acid transaminase activity”
L-methionine:oxo-acid transaminase activity database_cross_reference “RHEA:47800”
L-methionine:oxo-acid transaminase activity narrowMatch 47800
L-methionine:oxo-acid transaminase activity SubClassOf amino acid transaminase activity

L-ornithine catabolic process `http://purl.obolibrary.org/obo/GO_0006593`

Removed

L-ornithine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis.”
- database_cross_reference “GOC:jl”
- database_cross_reference “ISBN:0192801023”

Added

L-ornithine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-ornithine.”
- database_cross_reference “GOC:curators”
L-ornithine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI

L-ornithine transaminase activity `http://purl.obolibrary.org/obo/GO_0004587`

Removed

L-ornithine transaminase activity label “ornithine aminotransferase activity”
L-ornithine transaminase activity definition “Catalysis of the reaction: a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde.”
- database_cross_reference “EC:2.6.1.13”

Added

L-ornithine transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-ornithine transaminase activity definition “Catalysis of the reaction: a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid.”
- database_cross_reference “RHEA:13877”
L-ornithine transaminase activity narrowMatch 25160
L-ornithine transaminase activity database_cross_reference “RHEA:25160”
L-ornithine transaminase activity has_exact_synonym “ornithine aminotransferase activity”
L-ornithine transaminase activity label “L-ornithine transaminase activity”

L-ornithine transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0000064`

Added

L-ornithine transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9956519”
- label “SLC25A15 variants don’t translocate ornithine and citrulline”

L-phenylalaine oxidase activity `http://purl.obolibrary.org/obo/GO_0106329`

Removed

L-phenylalaine oxidase activity definition “Catalysis of the reaction: H2O + L-phenylalanine + O2 = 3-phenylpyruvate + H2O2 + NH4(+).”
- database_cross_reference “RHEA:61240”

Added

L-phenylalaine oxidase activity definition “Catalysis of the reaction: H2O + L-phenylalanine + O2 = 3-phenylpyruvate + H2O2 + NH4+.”
- database_cross_reference “RHEA:61240”

L-phenylalanine N-acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0050176`

Removed

L-phenylalanine N-acetyltransferase activity definition “Catalysis of the reaction: L-phenylalanine + acetyl-CoA = N-acetyl-L-phenylalanine + CoA + H+.”
- database_cross_reference “EC:2.3.1.53”
- database_cross_reference “RHEA:17801”

Added

L-phenylalanine N-acetyltransferase activity definition “Catalysis of the reaction: L-phenylalanine + acetyl-CoA = N-acetyl-L-phenylalanine + CoA + H+.”
- database_cross_reference “RHEA:17801”

L-phenylalanine biosynthetic process `http://purl.obolibrary.org/obo/GO_0009094`

Added

L-phenylalanine biosynthetic process narrowMatch PHESYN
L-phenylalanine biosynthetic process database_cross_reference “MetaCyc:PHESYN”
L-phenylalanine biosynthetic process database_cross_reference “MetaCyc:PWY-7432”
L-phenylalanine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
L-phenylalanine biosynthetic process narrowMatch PWY-7432
L-phenylalanine biosynthetic process narrowMatch PWY-3462
L-phenylalanine biosynthetic process database_cross_reference “MetaCyc:PWY-3462”

L-phenylalanine catabolic process `http://purl.obolibrary.org/obo/GO_0006559`

Removed

L-phenylalanine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-phenylalanine, 2-amino-3-phenylpropanoic acid.”
- database_cross_reference “GOC:go_curators”

Added

L-phenylalanine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-phenylalanine.”
- database_cross_reference “GOC:curators”
L-phenylalanine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI

L-phenylalanine:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0080130`

Removed

L-phenylalanine:2-oxoglutarate transaminase activity broadMatch 2.6.1.57
L-phenylalanine:2-oxoglutarate transaminase activity label “L-phenylalanine-2-oxoglutarate transaminase activity”

Added

L-phenylalanine:2-oxoglutarate transaminase activity has_exact_synonym “L-phenylalanine-2-oxoglutarate transaminase activity”
L-phenylalanine:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-phenylalanine:2-oxoglutarate transaminase activity label “L-phenylalanine:2-oxoglutarate transaminase activity”

L-phenylalanine:pyruvate transaminase activity `http://purl.obolibrary.org/obo/GO_0047312`

Removed

L-phenylalanine:pyruvate transaminase activity definition “Catalysis of the reaction: pyruvate + L-phenylalanine = phenylpyruvate + L-alanine.”
- database_cross_reference “RHEA:13053”
L-phenylalanine:pyruvate transaminase activity has_exact_synonym “L-phenylalanine:pyruvate transaminase activity”
- database_cross_reference “GOC:kad”
L-phenylalanine:pyruvate transaminase activity label “L-phenylalanine-pyruvate transaminase activity”
L-phenylalanine:pyruvate transaminase activity database_cross_reference “Reactome:R-HSA-893593”
- label “phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine”
L-phenylalanine:pyruvate transaminase activity SubClassOf aromatic-amino-acid:2-oxoglutarate transaminase activity

Added

L-phenylalanine:pyruvate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-phenylalanine:pyruvate transaminase activity database_cross_reference “Reactome:R-HSA-893593”
- label “phenylalanine + pyruvate => keto-phenylpyruvate + alanine”
L-phenylalanine:pyruvate transaminase activity definition “Catalysis of the reaction: L-phenylalanine + pyruvate = 3-phenylpyruvate + L-alanine.”
- database_cross_reference “RHEA:13053”
L-phenylalanine:pyruvate transaminase activity label “L-phenylalanine:pyruvate transaminase activity”
L-phenylalanine:pyruvate transaminase activity has_exact_synonym “L-phenylalanine-pyruvate transaminase activity”
L-phenylalanine:pyruvate transaminase activity SubClassOf L-alanine:oxo-acid transaminase activity

L-proline betaine catabolic process `http://purl.obolibrary.org/obo/GO_0019504`

Removed

L-proline betaine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline.”
- database_cross_reference “PMID:1804402”
- database_cross_reference “PMID:10689197”
- database_cross_reference “PMID:24520058”

Added

L-proline betaine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-proline betaine (stachydrine).”
- database_cross_reference “PMID:1804402”
- database_cross_reference “PMID:10689197”
- database_cross_reference “PMID:24520058”
L-proline betaine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI

L-proline biosynthetic process `http://purl.obolibrary.org/obo/GO_0055129`

Removed

L-proline biosynthetic process database_cross_reference “MetaCyc:PWY-4281”
- status “skos:narrowMatch”

Added

L-proline biosynthetic process narrowMatch ORN-AMINOPENTANOATE-CAT-PWY
L-proline biosynthetic process narrowMatch PWY-4281
L-proline biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
L-proline biosynthetic process database_cross_reference “MetaCyc:PWY-4281”
L-proline biosynthetic process database_cross_reference “MetaCyc:ORN-AMINOPENTANOATE-CAT-PWY”

L-proline catabolic process `http://purl.obolibrary.org/obo/GO_0006562`

Removed

L-proline catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.”
- database_cross_reference “GOC:jl”
- database_cross_reference “ISBN:0198506732”

Added

L-proline catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-proline.”
- database_cross_reference “GOC:curators”
L-proline catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI

L-selenocysteine biosynthetic process `http://purl.obolibrary.org/obo/GO_0016260`

Removed

L-selenocysteine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of L-selenocysteine, an essential component of glutathione peroxidase and some other proteins.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”
L-selenocysteine biosynthetic process SubClassOf obsolete selenocysteine metabolic process

Added

L-selenocysteine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of L-selenocysteine, an essential component of glutathione peroxidase and some other proteins.”
- database_cross_reference “PMID:17880704”

L-selenocysteine catabolic process `http://purl.obolibrary.org/obo/GO_0016261`

Removed

L-selenocysteine catabolic process label “selenocysteine catabolic process”
L-selenocysteine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of selenocysteine, an essential component of glutathione peroxidase and some other proteins.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”
L-selenocysteine catabolic process SubClassOf obsolete selenocysteine metabolic process

Added

L-selenocysteine catabolic process has_exact_synonym “selenocysteine catabolic process”
L-selenocysteine catabolic process label “L-selenocysteine catabolic process”
L-selenocysteine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of selenocysteine, an essential component of glutathione peroxidase and some other proteins.”
- database_cross_reference “PMID:12382038”

L-serine O-acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0009001`

Removed

L-serine O-acetyltransferase activity label “serine O-acetyltransferase activity”

Added

L-serine O-acetyltransferase activity has_broad_synonym “serine O-acetyltransferase activity”
L-serine O-acetyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31474”^^anyURI
L-serine O-acetyltransferase activity label “L-serine O-acetyltransferase activity”
L-serine O-acetyltransferase activity SubClassOf amino acid acyltransferase activity

L-serine ammonia-lyase activity `http://purl.obolibrary.org/obo/GO_0003941`

Removed

L-serine ammonia-lyase activity definition “Catalysis of the reaction: L-serine = pyruvate + NH3.”
- database_cross_reference “EC:4.3.1.17”

Added

L-serine ammonia-lyase activity definition “Catalysis of the reaction: L-serine = pyruvate + NH4+.”
- database_cross_reference “RHEA:19169”
L-serine ammonia-lyase activity database_cross_reference “Reactome:R-HSA-9929460”
- label “SDS dimers:PXLP convert L-Ser to PYR and NH4+”

L-serine biosynthetic process `http://purl.obolibrary.org/obo/GO_0006564`

Removed

L-serine biosynthetic process exactMatch SERSYN-PWY
L-serine biosynthetic process database_cross_reference “Reactome:R-HSA-977347”
- label “Serine biosynthesis”

Added

L-serine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
L-serine biosynthetic process narrowMatch PWY-8011
L-serine biosynthetic process narrowMatch SERSYN-PWY
L-serine biosynthetic process database_cross_reference “MetaCyc:PWY-8011”

L-serine catabolic process `http://purl.obolibrary.org/obo/GO_0006565`

Removed

L-serine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-serine to pyruvate and free ammonium.”
- database_cross_reference “MetaCyc:SERDEG-PWY”

Added

L-serine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI
L-serine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-serine.”
- database_cross_reference “GOC:curators”

L-serine metabolic process `http://purl.obolibrary.org/obo/GO_0006563`

Added

L-serine metabolic process database_cross_reference “Reactome:R-HSA-977347”
- label “Serine metabolism”

L-serine transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015194`

Removed

L-serine transmembrane transporter activity database_cross_reference “Reactome:R-HSA-8932980”
- label “SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane”

L-serine:glyoxylate transaminase activity `http://purl.obolibrary.org/obo/GO_0050281`

Removed

L-serine:glyoxylate transaminase activity definition “Catalysis of the reaction: L-serine + glyoxylate = 3-hydroxypyruvate + glycine.”
- database_cross_reference “EC:2.6.1.45”
L-serine:glyoxylate transaminase activity label “L-serine-glyoxylate transaminase activity”
L-serine:glyoxylate transaminase activity SubClassOf transaminase activity

Added

L-serine:glyoxylate transaminase activity has_exact_synonym “L-serine-glyoxylate transaminase activity”
L-serine:glyoxylate transaminase activity definition “Catalysis of the reaction: L-serine + glyoxylate = 3-hydroxypyruvate + glycine.”
- database_cross_reference “RHEA:19125”
L-serine:glyoxylate transaminase activity label “L-serine:glyoxylate transaminase activity”
L-serine:glyoxylate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-serine:glyoxylate transaminase activity SubClassOf amino acid transaminase activity

L-serine:pyruvate transaminase activity `http://purl.obolibrary.org/obo/GO_0004760`

Removed

L-serine:pyruvate transaminase activity definition “Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine.”
- database_cross_reference “EC:2.6.1.51”
- database_cross_reference “RHEA:22852”
L-serine:pyruvate transaminase activity label “L-serine-pyruvate transaminase activity”
L-serine:pyruvate transaminase activity SubClassOf transaminase activity

Added

L-serine:pyruvate transaminase activity label “L-serine:pyruvate transaminase activity”
L-serine:pyruvate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-serine:pyruvate transaminase activity definition “Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine.”
- database_cross_reference “RHEA:22852”
L-serine:pyruvate transaminase activity has_exact_synonym “L-serine-pyruvate transaminase activity”
L-serine:pyruvate transaminase activity SubClassOf L-alanine:oxo-acid transaminase activity

L-threonine 3-dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0008743`

Removed

L-threonine 3-dehydrogenase activity database_cross_reference “Reactome:R-HSA-6798667”
- label “TDH tetramer oxidises L-Thr to 2A-3OB”

L-threonine biosynthetic process `http://purl.obolibrary.org/obo/GO_0009088`

Removed

L-threonine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of L-threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.”
- database_cross_reference “GOC:jl”
- database_cross_reference “MetaCyc:THRESYN-PWY”
- database_cross_reference “ISBN:0198506732”
L-threonine biosynthetic process database_cross_reference “MetaCyc:THRESYN-PWY”
L-threonine biosynthetic process narrowMatch THRESYN-PWY

Added

L-threonine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of L-threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.”
- database_cross_reference “GOC:jl”
- database_cross_reference “ISBN:0198506732”
L-threonine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI

L-threonine catabolic process `http://purl.obolibrary.org/obo/GO_0006567`

Removed

L-threonine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.”
- database_cross_reference “GOC:jl”
- database_cross_reference “ISBN:0198506732”

Added

L-threonine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI
L-threonine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-threonine.”
- database_cross_reference “GOC:curators”

L-threonylcarbamoyladenylate synthase activity `http://purl.obolibrary.org/obo/GO_0061710`

Added

L-threonylcarbamoyladenylate synthase activity database_cross_reference “Reactome:R-HSA-9611218”
- label “YRDC synthesizes threonylcarbamoyladenylate”

L-tryptophan catabolic process `http://purl.obolibrary.org/obo/GO_0006569`

Removed

L-tryptophan catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.”
- database_cross_reference “ISBN:0198547684”

Added

L-tryptophan catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI
L-tryptophan catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-tryptophan.”
- database_cross_reference “GOC:curators”

L-tryptophan conjugated cholate hydrolase activity `http://purl.obolibrary.org/obo/GO_7770009`

Removed

L-tryptophan conjugated cholate hydrolase activity definition “Catalysis of the reaction: cholate + L-tryptophan = L-tryptophocholate + H2O.”
- database_cross_reference “PMID:40446798”

Added

L-tryptophan conjugated cholate hydrolase activity definition “Catalysis of the reaction: cholate + L-tryptophan = L-tryptophocholate + H2O.”
- database_cross_reference “PMID:40446798”
- database_cross_reference “RHEA:85423”
L-tryptophan conjugated cholate hydrolase activity database_cross_reference “RHEA:85423”
L-tryptophan conjugated cholate hydrolase activity exactMatch 85423

L-tryptophan dehydrogenase [NAD(P)+] activity `http://purl.obolibrary.org/obo/GO_0050363`

Removed

L-tryptophan dehydrogenase [NAD(P)+] activity exactMatch 13473
L-tryptophan dehydrogenase [NAD(P)+] activity definition “Catalysis of the reaction: L-tryptophan + NAD+ + H2O = indole-3-pyruvate + NH4+ + NADH + H+.”
- database_cross_reference “RHEA:13473”
L-tryptophan dehydrogenase [NAD(P)+] activity label “L-tryptophan dehydrogenase (NAD+) activity”
L-tryptophan dehydrogenase [NAD(P)+] activity relatedMatch 13477

Added

L-tryptophan dehydrogenase [NAD(P)+] activity database_cross_reference “RHEA:13477”
L-tryptophan dehydrogenase [NAD(P)+] activity definition “Catalysis of the reaction: L-tryptophan + NAD(P)+ + H2O = indole-3-pyruvate + NH4+ + NAD(P)H + H+.”
- database_cross_reference “EC:1.4.1.19”
L-tryptophan dehydrogenase [NAD(P)+] activity term tracker item “https://github.com/geneontology/go-ontology/issues/31730”^^anyURI
L-tryptophan dehydrogenase [NAD(P)+] activity has_narrow_synonym “L-tryptophan dehydrogenase (NAD+) activity”
L-tryptophan dehydrogenase [NAD(P)+] activity label “L-tryptophan dehydrogenase [NAD(P)+] activity”
L-tryptophan dehydrogenase [NAD(P)+] activity narrowMatch 13473
L-tryptophan dehydrogenase [NAD(P)+] activity narrowMatch 13477

L-tryptophan:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0050362`

Removed

L-tryptophan:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: L-tryptophan + 2-oxoglutarate = indolepyruvate + L-glutamate.”
- database_cross_reference “EC:2.6.1.27”
- database_cross_reference “MetaCyc:TRYPTOPHAN-AMINOTRANSFERASE-RXN”
L-tryptophan:2-oxoglutarate transaminase activity label “L-tryptophan:2-oxoglutarate aminotransferase activity”
L-tryptophan:2-oxoglutarate transaminase activity SubClassOf obsolete L-tryptophan transaminase activity

Added

L-tryptophan:2-oxoglutarate transaminase activity has_exact_synonym “L-tryptophan:2-oxoglutarate aminotransferase activity”
L-tryptophan:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-tryptophan:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: L-tryptophan + 2-oxoglutarate = indole-3-pyruvate + L-glutamate.”
- database_cross_reference “RHEA:14093”
L-tryptophan:2-oxoglutarate transaminase activity label “L-tryptophan:2-oxoglutarate transaminase activity”
L-tryptophan:2-oxoglutarate transaminase activity SubClassOf aromatic-amino-acid:2-oxoglutarate transaminase activity

L-tryptophan:phenylpyruvate transaminase activity `http://purl.obolibrary.org/obo/GO_0047299`

Removed

L-tryptophan:phenylpyruvate transaminase activity definition “Catalysis of the reaction: keto-phenylpyruvate + L-tryptophan = 3-(indol-3-yl)pyruvate + L-phenylalanine.”
- database_cross_reference “RHEA:13741”
- database_cross_reference “EC:2.6.1.28”
L-tryptophan:phenylpyruvate transaminase activity label “tryptophan-phenylpyruvate transaminase activity”
L-tryptophan:phenylpyruvate transaminase activity SubClassOf transaminase activity

Added

L-tryptophan:phenylpyruvate transaminase activity has_exact_synonym “tryptophan-phenylpyruvate transaminase activity”
L-tryptophan:phenylpyruvate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-tryptophan:phenylpyruvate transaminase activity definition “Catalysis of the reaction: 3-phenylpyruvate + L-tryptophan = indole-3-pyruvate + L-phenylalanine.”
- database_cross_reference “RHEA:13741”
L-tryptophan:phenylpyruvate transaminase activity label “L-tryptophan:phenylpyruvate transaminase activity”
L-tryptophan:phenylpyruvate transaminase activity SubClassOf amino acid transaminase activity

L-tryptophan:pyruvate transaminase activity `http://purl.obolibrary.org/obo/GO_0080097`

Removed

L-tryptophan:pyruvate transaminase activity label “L-tryptophan:pyruvate aminotransferase activity”
L-tryptophan:pyruvate transaminase activity definition “Catalysis of the reaction: L-tryptophan + pyruvate = 3-(indol-3-yl)pyruvate + L-alanine.”
- database_cross_reference “RHEA:27586”
L-tryptophan:pyruvate transaminase activity SubClassOf obsolete L-tryptophan transaminase activity

Added

L-tryptophan:pyruvate transaminase activity has_exact_synonym “L-tryptophan:pyruvate aminotransferase activity”
L-tryptophan:pyruvate transaminase activity definition “Catalysis of the reaction: L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine.”
- database_cross_reference “RHEA:27586”
L-tryptophan:pyruvate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-tryptophan:pyruvate transaminase activity label “L-tryptophan:pyruvate transaminase activity”
L-tryptophan:pyruvate transaminase activity SubClassOf L-alanine:oxo-acid transaminase activity

L-tyrosine biosynthetic process `http://purl.obolibrary.org/obo/GO_0006571`

Added

L-tyrosine biosynthetic process narrowMatch PWY-6120
L-tyrosine biosynthetic process database_cross_reference “MetaCyc:PWY-6120”
L-tyrosine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
L-tyrosine biosynthetic process narrowMatch PWY-6134
L-tyrosine biosynthetic process narrowMatch PWY-3461
L-tyrosine biosynthetic process has_alternative_id “GO:0019291”
L-tyrosine biosynthetic process narrowMatch TYRSYN
L-tyrosine biosynthetic process database_cross_reference “MetaCyc:TYRSYN”
L-tyrosine biosynthetic process database_cross_reference “MetaCyc:PWY-6134”
L-tyrosine biosynthetic process database_cross_reference “MetaCyc:PWY-3461”

L-tyrosine catabolic process `http://purl.obolibrary.org/obo/GO_0006572`

Removed

L-tyrosine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.”
- database_cross_reference “GOC:go_curators”

Added

L-tyrosine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-tyrosine.”
- database_cross_reference “GOC:curators”
L-tyrosine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI

L-tyrosine:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0004838`

Removed

L-tyrosine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.”
- database_cross_reference “RHEA:15093”
L-tyrosine:2-oxoglutarate transaminase activity label “L-tyrosine-2-oxoglutarate transaminase activity”

Added

L-tyrosine:2-oxoglutarate transaminase activity label “L-tyrosine:2-oxoglutarate transaminase activity”
L-tyrosine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate.”
- database_cross_reference “RHEA:15093”
L-tyrosine:2-oxoglutarate transaminase activity has_exact_synonym “L-tyrosine-2-oxoglutarate transaminase activity”
L-tyrosine:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI

L-tyrosine:pyruvate transaminase activity `http://purl.obolibrary.org/obo/GO_0080098`

Removed

L-tyrosine:pyruvate transaminase activity label “L-tyrosine-pyruvate transaminase activity”
L-tyrosine:pyruvate transaminase activity definition “Catalysis of the reaction: L-tyrosine + pyruvate = (4-hydroxyphenyl)pyruvate + L-alanine.”
- database_cross_reference “MetaCyc:RXN3O-4157”
L-tyrosine:pyruvate transaminase activity SubClassOf aromatic-amino-acid:2-oxoglutarate transaminase activity

Added

L-tyrosine:pyruvate transaminase activity has_exact_synonym “L-tyrosine-pyruvate transaminase activity”
L-tyrosine:pyruvate transaminase activity definition “Catalysis of the reaction: L-tyrosine + pyruvate = 3-(4-hydroxyphenyl)pyruvate + L-alanine.”
- database_cross_reference “MetaCyc:RXN3O-4157”
L-tyrosine:pyruvate transaminase activity exactMatch RXN3O-4157
L-tyrosine:pyruvate transaminase activity label “L-tyrosine:pyruvate transaminase activity”
L-tyrosine:pyruvate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-tyrosine:pyruvate transaminase activity SubClassOf amino acid transaminase activity

L-valine catabolic process `http://purl.obolibrary.org/obo/GO_0006574`

Removed

L-valine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-valine, 2-amino-3-methylbutanoic acid.”
- database_cross_reference “GOC:ai”

Added

L-valine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of L-valine.”
- database_cross_reference “GOC:curators”
L-valine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI

L-valine:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0052655`

Removed

L-valine:2-oxoglutarate transaminase activity label “L-valine-2-oxoglutarate transaminase activity”
L-valine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid.”
- database_cross_reference “RHEA:24813”

Added

L-valine:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-valine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate.”
- database_cross_reference “RHEA:24813”
L-valine:2-oxoglutarate transaminase activity label “L-valine:2-oxoglutarate transaminase activity”
L-valine:2-oxoglutarate transaminase activity has_exact_synonym “L-valine-2-oxoglutarate transaminase activity”

L-valine:3-methyl-2-oxovalerate transaminase activity `http://purl.obolibrary.org/obo/GO_0047301`

Removed

L-valine:3-methyl-2-oxovalerate transaminase activity label “valine-3-methyl-2-oxovalerate transaminase activity”
L-valine:3-methyl-2-oxovalerate transaminase activity definition “Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + L-valine = 3-methyl-2-oxobutanoate + L-isoleucine.”
- database_cross_reference “EC:2.6.1.32”
- database_cross_reference “RHEA:11468”
L-valine:3-methyl-2-oxovalerate transaminase activity SubClassOf transaminase activity

Added

L-valine:3-methyl-2-oxovalerate transaminase activity definition “Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + L-valine = 3-methyl-2-oxobutanoate + L-isoleucine.”
- database_cross_reference “RHEA:11468”
L-valine:3-methyl-2-oxovalerate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-valine:3-methyl-2-oxovalerate transaminase activity label “L-valine:3-methyl-2-oxovalerate transaminase activity”
L-valine:3-methyl-2-oxovalerate transaminase activity has_exact_synonym “valine-3-methyl-2-oxovalerate transaminase activity”
L-valine:3-methyl-2-oxovalerate transaminase activity SubClassOf amino acid transaminase activity

L-valine:pyruvate transaminase activity `http://purl.obolibrary.org/obo/GO_0009042`

Removed

L-valine:pyruvate transaminase activity definition “Catalysis of the reaction: L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine.”
- database_cross_reference “EC:2.6.1.66”
- database_cross_reference “RHEA:22912”
L-valine:pyruvate transaminase activity label “valine-pyruvate transaminase activity”
L-valine:pyruvate transaminase activity SubClassOf transaminase activity

Added

L-valine:pyruvate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
L-valine:pyruvate transaminase activity definition “Catalysis of the reaction: L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine.”
- database_cross_reference “RHEA:22912”
L-valine:pyruvate transaminase activity label “L-valine:pyruvate transaminase activity”
L-valine:pyruvate transaminase activity has_exact_synonym “valine-pyruvate transaminase activity”
L-valine:pyruvate transaminase activity SubClassOf L-alanine:oxo-acid transaminase activity

LIM domain binding `http://purl.obolibrary.org/obo/GO_0030274`

Removed

LIM domain binding definition “Binding to a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions.”
- database_cross_reference “Pfam:PF00412”
- database_cross_reference “GOC:go_curators”

Added

LIM domain binding definition “Binding to a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions.”
- database_cross_reference “GOC:curators”
- database_cross_reference “Pfam:PF00412”

LRR domain binding `http://purl.obolibrary.org/obo/GO_0030275`

Removed

LRR domain binding definition “Binding to a LRR domain (leucine rich repeats) of a protein.”
- database_cross_reference “Pfam:PF00560”
- database_cross_reference “GOC:go_curators”

Added

LRR domain binding definition “Binding to a LRR domain (leucine rich repeats) of a protein.”
- database_cross_reference “GOC:curators”
- database_cross_reference “Pfam:PF00560”

MAP kinase scaffold activity `http://purl.obolibrary.org/obo/GO_0005078`

Removed

MAP kinase scaffold activity label “MAP-kinase scaffold activity”

Added

MAP kinase scaffold activity label “MAP kinase scaffold activity”
MAP kinase scaffold activity SubClassOf protein complex scaffold activity

MHC class I biosynthetic process `http://purl.obolibrary.org/obo/GO_0045341`

Removed

MHC class I biosynthetic process definition “The chemical reactions and pathways resulting in the formation of major histocompatibility protein class I.”
- database_cross_reference “GOC:go_curators”

Added

MHC class I biosynthetic process definition “The chemical reactions and pathways resulting in the formation of major histocompatibility protein class I.”
- database_cross_reference “GOC:curators”

MHC class II biosynthetic process `http://purl.obolibrary.org/obo/GO_0045342`

Removed

MHC class II biosynthetic process definition “The chemical reactions and pathways resulting in the formation of major histocompatibility protein class II.”
- database_cross_reference “GOC:go_curators”

Added

MHC class II biosynthetic process definition “The chemical reactions and pathways resulting in the formation of major histocompatibility protein class II.”
- database_cross_reference “GOC:curators”

Mo(VI)-molybdopterin cytosine dinucleotide biosynthetic process `http://purl.obolibrary.org/obo/GO_1902760`

Added

Mo(VI)-molybdopterin cytosine dinucleotide biosynthetic process SubClassOf nucleotide biosynthetic process

N(1)-acetylpolyamine oxidase activity `http://purl.obolibrary.org/obo/GO_0052903`

Removed

N(1)-acetylpolyamine oxidase activity database_cross_reference “MetaCyc:RXN-12090”
N(1)-acetylpolyamine oxidase activity exactMatch RXN-12090
N(1)-acetylpolyamine oxidase activity relatedMatch RXN-9940

Added

N(1)-acetylpolyamine oxidase activity narrowMatch RXN-10460
N(1)-acetylpolyamine oxidase activity database_cross_reference “MetaCyc:RXN-10460”
N(1)-acetylpolyamine oxidase activity database_cross_reference “Reactome:R-HSA-141351”
- label “PAOX:FAD oxidises NASPN to SPM”
N(1)-acetylpolyamine oxidase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI
N(1)-acetylpolyamine oxidase activity narrowMatch RXN-9940
N(1)-acetylpolyamine oxidase activity database_cross_reference “MetaCyc:RXN-9940”
N(1)-acetylpolyamine oxidase activity narrowMatch RXN-12091
N(1)-acetylpolyamine oxidase activity database_cross_reference “MetaCyc:RXN-12091”
N(1)-acetylpolyamine oxidase activity database_cross_reference “Reactome:R-HSA-141348”
- label “PAO:FAD oxidises NASPM to PTCN”

N-(long-chain-acyl)ethanolamine deacylase activity `http://purl.obolibrary.org/obo/GO_0047412`

Added

N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity `http://purl.obolibrary.org/obo/GO_0008499`

Removed

N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity database_cross_reference “Reactome:R-HSA-914010”
- label “Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein”

N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity `http://purl.obolibrary.org/obo/GO_0033842`

Added

N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity `http://purl.obolibrary.org/obo/GO_0050659`

Removed

N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity database_cross_reference “Reactome:R-HSA-2018659”
- label “Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15”

Added

N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity database_cross_reference “Reactome:R-HSA-2018659”
- label “CHST15 transfers sulfate to (6-)GalNAc-4-sulfate”
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity database_cross_reference “Reactome:R-HSA-9941312”
- label “CHST15 transfers sulfate to (6-)GalNAc-4-sulfate”

N-acetylgalactosaminide beta-1,3-galactosyltransferase activity `http://purl.obolibrary.org/obo/GO_0016263`

Added

N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity `http://purl.obolibrary.org/obo/GO_0050510`

Removed

N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity database_cross_reference “Reactome:R-HSA-1971491”
- label “CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin”
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity database_cross_reference “Reactome:R-HSA-9632034”
- label “CHSY1 transfers GlcA to chondroitin”

Added

N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity database_cross_reference “Reactome:R-HSA-1971491”
- label “Chondroitin polymerase complex transfers GlcA to CS chain”

N-acetylglucosamine 6-O-sulfotransferase activity `http://purl.obolibrary.org/obo/GO_0001517`

Removed

N-acetylglucosamine 6-O-sulfotransferase activity database_cross_reference “Reactome:R-HSA-2046222”
- label “CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG”

Added

N-acetylglucosamine 6-O-sulfotransferase activity database_cross_reference “Reactome:R-HSA-2046222”
- label “CHST2,3,5,6 transfer sulfate to GlcNAc on keratan chain”

N-acetylglucosamine biosynthetic process `http://purl.obolibrary.org/obo/GO_0006045`

Added

N-acetylglucosamine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/27059”^^anyURI

N-acetylglucosamine catabolic process `http://purl.obolibrary.org/obo/GO_0006046`

Added

N-acetylglucosamine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/27059”^^anyURI

N-acetylglucosamine metabolic process `http://purl.obolibrary.org/obo/GO_0006044`

Added

N-acetylglucosamine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/27059”^^anyURI

N-acetylglucosamine transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015572`

Added

N-acetylglucosamine transmembrane transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/27059”^^anyURI

N-acetylglucosamine transport `http://purl.obolibrary.org/obo/GO_0015764`

Added

N-acetylglucosamine transport term tracker item “https://github.com/geneontology/go-ontology/issues/27059”^^anyURI

N-acetylglucosamine-6-sulfatase activity `http://purl.obolibrary.org/obo/GO_0008449`

Removed

N-acetylglucosamine-6-sulfatase activity database_cross_reference “Reactome:R-HSA-1638032”
- label “N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate”

Added

N-acetylglucosamine-6-sulfatase activity database_cross_reference “Reactome:R-HSA-1638032”
- label “GNS:Ca2+ cleaves sulfate from GlcNAc-6-sulfate units of keratan sulfate”

N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity `http://purl.obolibrary.org/obo/GO_0050509`

Removed

N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity database_cross_reference “Reactome:R-HSA-2022856”
- label “EXT1:EXT2 transfers GlcNAc to heparan”

Added

N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity database_cross_reference “Reactome:R-HSA-2022856”
- label “EXT1:EXT2 transfers GlcA to heparan”

N-acetyllactosaminide alpha-2,3-sialyltransferase activity `http://purl.obolibrary.org/obo/GO_0008118`

Added

N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity `http://purl.obolibrary.org/obo/GO_0008532`

Added

N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity database_cross_reference “Reactome:R-HSA-9931297”
- label “B3GNT3 mediated CD274 glycosylation in Golgi”
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity database_cross_reference “RHEA:82971”
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity narrowMatch 82955
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity narrowMatch 82971
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity database_cross_reference “RHEA:82955”

N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity `http://purl.obolibrary.org/obo/GO_0008109`

Added

N-acetylneuraminate catabolic process `http://purl.obolibrary.org/obo/GO_0019262`

Added

N-acetylneuraminate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31361”^^anyURI

N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity `http://purl.obolibrary.org/obo/GO_0047233`

Added

N-acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0008080`

Added

N-acetyltransferase activity database_cross_reference “Reactome:R-HSA-9913373”
- label “AAC(6)-Ib acetylates ciprofloxacin”

N-acylglucosamine-6-phosphate 2-epimerase activity `http://purl.obolibrary.org/obo/GO_0047465`

Added

N-acylmannosamine kinase activity `http://purl.obolibrary.org/obo/GO_0009384`

Added

N-acylmannosamine kinase activity database_cross_reference “RHEA:25253”
N-acylmannosamine kinase activity narrowMatch 25253

N-acylneuraminate cytidylyltransferase activity `http://purl.obolibrary.org/obo/GO_0008781`

Added

N-acylneuraminate-9-phosphatase activity `http://purl.obolibrary.org/obo/GO_0050124`

Added

N-acylneuraminate-9-phosphatase activity database_cross_reference “RHEA:80839”
N-acylneuraminate-9-phosphatase activity database_cross_reference “RHEA:83303”
N-acylneuraminate-9-phosphatase activity narrowMatch 80839
N-acylneuraminate-9-phosphatase activity narrowMatch 83303

N-acylneuraminate-9-phosphate synthase activity `http://purl.obolibrary.org/obo/GO_0047444`

Added

N-acylphosphatidylethanolamine-specific phospholipase D activity `http://purl.obolibrary.org/obo/GO_0070290`

Added

N-acylsphingosine amidohydrolase activity `http://purl.obolibrary.org/obo/GO_0017040`

Added

N-acylsphingosine amidohydrolase activity narrowMatch 58484
N-acylsphingosine amidohydrolase activity database_cross_reference “Reactome:R-HSA-428262”
- label “ACER3 hydrolyzes phytoceramide”
N-acylsphingosine amidohydrolase activity narrowMatch 41291
N-acylsphingosine amidohydrolase activity database_cross_reference “RHEA:41267”
N-acylsphingosine amidohydrolase activity narrowMatch 38891
N-acylsphingosine amidohydrolase activity narrowMatch 41279
N-acylsphingosine amidohydrolase activity database_cross_reference “RHEA:41275”
N-acylsphingosine amidohydrolase activity narrowMatch 45356
N-acylsphingosine amidohydrolase activity narrowMatch 41299
N-acylsphingosine amidohydrolase activity narrowMatch 45348
N-acylsphingosine amidohydrolase activity database_cross_reference “RHEA:45348”
N-acylsphingosine amidohydrolase activity narrowMatch 41283
N-acylsphingosine amidohydrolase activity database_cross_reference “RHEA:41299”
N-acylsphingosine amidohydrolase activity narrowMatch 45092
N-acylsphingosine amidohydrolase activity database_cross_reference “RHEA:41295”
N-acylsphingosine amidohydrolase activity narrowMatch 41267
N-acylsphingosine amidohydrolase activity database_cross_reference “RHEA:41291”
N-acylsphingosine amidohydrolase activity database_cross_reference “RHEA:41279”
N-acylsphingosine amidohydrolase activity narrowMatch 41275
N-acylsphingosine amidohydrolase activity database_cross_reference “RHEA:41287”
N-acylsphingosine amidohydrolase activity database_cross_reference “RHEA:45356”
N-acylsphingosine amidohydrolase activity database_cross_reference “RHEA:38891”
N-acylsphingosine amidohydrolase activity narrowMatch 41295
N-acylsphingosine amidohydrolase activity database_cross_reference “RHEA:58484”
N-acylsphingosine amidohydrolase activity database_cross_reference “RHEA:41283”
N-acylsphingosine amidohydrolase activity database_cross_reference “RHEA:45092”
N-acylsphingosine amidohydrolase activity narrowMatch 41287

N-acylsphingosine galactosyltransferase activity `http://purl.obolibrary.org/obo/GO_0003851`

Added

N-carbamoyl-D-amino acid hydrolase activity `http://purl.obolibrary.org/obo/GO_0047417`

Removed

N-carbamoyl-D-amino acid hydrolase activity definition “Catalysis of the reaction: H2O + N-carbamoyl-D-amino acid = CO2 + NH3 + D-amino acid.”
- database_cross_reference “MetaCyc:3.5.1.77-RXN”
- database_cross_reference “EC:3.5.1.77”

Added

N-carbamoyl-D-amino acid hydrolase activity definition “Catalysis of the reaction: an N-carbamoyl-D-amino acid + H2O + 2 H+ = a D-alpha-amino acid + NH4+ + CO2.”
- database_cross_reference “RHEA:11000”

N-carbamoyl-L-amino-acid hydrolase activity `http://purl.obolibrary.org/obo/GO_0050538`

Added

N-carbamoyl-L-amino-acid hydrolase activity narrowMatch 84015
N-carbamoyl-L-amino-acid hydrolase activity narrowMatch 83915
N-carbamoyl-L-amino-acid hydrolase activity narrowMatch 84023
N-carbamoyl-L-amino-acid hydrolase activity narrowMatch 83911
N-carbamoyl-L-amino-acid hydrolase activity database_cross_reference “RHEA:84019”
N-carbamoyl-L-amino-acid hydrolase activity database_cross_reference “RHEA:72783”
N-carbamoyl-L-amino-acid hydrolase activity narrowMatch 84011
N-carbamoyl-L-amino-acid hydrolase activity database_cross_reference “RHEA:72787”
N-carbamoyl-L-amino-acid hydrolase activity database_cross_reference “RHEA:72827”
N-carbamoyl-L-amino-acid hydrolase activity narrowMatch 72783
N-carbamoyl-L-amino-acid hydrolase activity database_cross_reference “RHEA:84011”
N-carbamoyl-L-amino-acid hydrolase activity database_cross_reference “RHEA:84015”
N-carbamoyl-L-amino-acid hydrolase activity database_cross_reference “RHEA:83915”
N-carbamoyl-L-amino-acid hydrolase activity narrowMatch 84019
N-carbamoyl-L-amino-acid hydrolase activity database_cross_reference “RHEA:72823”
N-carbamoyl-L-amino-acid hydrolase activity narrowMatch 72823
N-carbamoyl-L-amino-acid hydrolase activity narrowMatch 72827
N-carbamoyl-L-amino-acid hydrolase activity database_cross_reference “RHEA:84023”
N-carbamoyl-L-amino-acid hydrolase activity narrowMatch 72787
N-carbamoyl-L-amino-acid hydrolase activity database_cross_reference “RHEA:83911”

N-methyl-L-amino-acid oxidase activity `http://purl.obolibrary.org/obo/GO_0050131`

Added

N-methyl-L-amino-acid oxidase activity database_cross_reference “RHEA:28006”
N-methyl-L-amino-acid oxidase activity narrowMatch 28006

N2-acetyl-L-ornithine:2-oxoglutarate 5-transaminase activity `http://purl.obolibrary.org/obo/GO_0003992`

Removed

N2-acetyl-L-ornithine:2-oxoglutarate 5-transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + N(2)-acetyl-L-ornithine = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.”
- database_cross_reference “RHEA:18049”
- database_cross_reference “EC:2.6.1.11”
N2-acetyl-L-ornithine:2-oxoglutarate 5-transaminase activity label “N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity”

Added

N2-acetyl-L-ornithine:2-oxoglutarate 5-transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
N2-acetyl-L-ornithine:2-oxoglutarate 5-transaminase activity label “N2-acetyl-L-ornithine:2-oxoglutarate 5-transaminase activity”
N2-acetyl-L-ornithine:2-oxoglutarate 5-transaminase activity has_exact_synonym “N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity”
N2-acetyl-L-ornithine:2-oxoglutarate 5-transaminase activity definition “Catalysis of the reaction: N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.”
- database_cross_reference “RHEA:18049”

N6-acetyl-beta-lysine:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0047317`

Removed

N6-acetyl-beta-lysine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + 3-amino-6-acetamidohexanoate = L-glutamate + 3-oxo-6-acetamidohexanoate.”
- database_cross_reference “MetaCyc:2.6.1.65-RXN”
- database_cross_reference “EC:2.6.1.65”
N6-acetyl-beta-lysine:2-oxoglutarate transaminase activity label “N6-acetyl-beta-lysine transaminase activity”

Added

N6-acetyl-beta-lysine:2-oxoglutarate transaminase activity has_exact_synonym “N6-acetyl-beta-lysine transaminase activity”
N6-acetyl-beta-lysine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + 3-amino-6-acetamidohexanoate = L-glutamate + 3-oxo-6-acetamidohexanoate.”
- database_cross_reference “RHEA:16889”
N6-acetyl-beta-lysine:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
N6-acetyl-beta-lysine:2-oxoglutarate transaminase activity label “N6-acetyl-beta-lysine:2-oxoglutarate transaminase activity”

N6-hydroxylysine O-acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0050133`

Added

N6-hydroxylysine O-acetyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31474”^^anyURI
N6-hydroxylysine O-acetyltransferase activity SubClassOf amino acid acyltransferase activity

NAD transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0051724`

Added

NAD transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9938195”
- label “SLC25A51 mediates mitochondrial uptake of NAD+”

NAD(P)H oxidase H2O2-forming activity `http://purl.obolibrary.org/obo/GO_0016174`

Removed

NAD(P)H oxidase H2O2-forming activity definition “Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide.”
- database_cross_reference “PMID:10401672”
- database_cross_reference “PMID:11822874”
- database_cross_reference “EC:1.6.3.1”
- database_cross_reference “PMID:10601291”
NAD(P)H oxidase H2O2-forming activity database_cross_reference “Reactome:R-HSA-5693681”
- label “DUOX1,2 reduce O2 to H2O2”

Added

NAD(P)H oxidase H2O2-forming activity definition “Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + H2O2.”
- database_cross_reference “PMID:10401672”
- database_cross_reference “PMID:11822874”
- database_cross_reference “EC:1.6.3.1”
- database_cross_reference “PMID:10601291”
NAD(P)H oxidase H2O2-forming activity database_cross_reference “Reactome:R-HSA-5693681”
- label “DUOX1 reduces O2 to H2O2”

NAD(P)H sulfur oxidoreductase (CoA-dependent) activity `http://purl.obolibrary.org/obo/GO_0043914`

Removed

NAD(P)H sulfur oxidoreductase (CoA-dependent) activity label “NADPH:sulfur oxidoreductase activity”
NAD(P)H sulfur oxidoreductase (CoA-dependent) activity definition “Catalysis of the reaction: NADPH + H+ + sulfur = hydrogen sulfide + NADP+.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:17449625”
NAD(P)H sulfur oxidoreductase (CoA-dependent) activity SubClassOf oxidoreductase activity, acting on a sulfur group of donors

Added

NAD(P)H sulfur oxidoreductase (CoA-dependent) activity definition “Catalysis of the reaction: hydrogen sulfide + NAD(P)+ = sulfur + NAD(P)H.”
- database_cross_reference “EC:1.8.1.18”
- database_cross_reference “PMID:17449625”
NAD(P)H sulfur oxidoreductase (CoA-dependent) activity label “NAD(P)H sulfur oxidoreductase (CoA-dependent) activity”
NAD(P)H sulfur oxidoreductase (CoA-dependent) activity has_narrow_synonym “NADPH:sulfur oxidoreductase activity”
NAD(P)H sulfur oxidoreductase (CoA-dependent) activity database_cross_reference “RHEA:36595”
NAD(P)H sulfur oxidoreductase (CoA-dependent) activity term tracker item “https://github.com/geneontology/go-ontology/issues/31518”^^anyURI
NAD(P)H sulfur oxidoreductase (CoA-dependent) activity narrowMatch 36595
NAD(P)H sulfur oxidoreductase (CoA-dependent) activity database_cross_reference “RHEA:36599”
NAD(P)H sulfur oxidoreductase (CoA-dependent) activity narrowMatch 36599
NAD(P)H sulfur oxidoreductase (CoA-dependent) activity SubClassOf oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

NAD(P)HX epimerase activity `http://purl.obolibrary.org/obo/GO_0052856`

Added

NAD(P)HX epimerase activity database_cross_reference “Reactome:R-HSA-6806966”
- label “APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX”

NAD+ biosynthetic process via the salvage pathway `http://purl.obolibrary.org/obo/GO_0034355`

Added

NAD+ biosynthetic process via the salvage pathway narrowMatch PWY3O-4106
NAD+ biosynthetic process via the salvage pathway database_cross_reference “MetaCyc:NAD-BIOSYNTHESIS-II”
NAD+ biosynthetic process via the salvage pathway term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
NAD+ biosynthetic process via the salvage pathway database_cross_reference “MetaCyc:PWY3O-4106”
NAD+ biosynthetic process via the salvage pathway narrowMatch NAD-BIOSYNTHESIS-II

NAD+ catabolic process `http://purl.obolibrary.org/obo/GO_0019677`

Removed

NAD+ catabolic process database_cross_reference “MetaCyc:NAD-BIOSYNTHESIS-II”

NAD+ metabolic process `http://purl.obolibrary.org/obo/GO_0019674`

Removed

NAD+ metabolic process database_cross_reference “Reactome:R-HSA-196807”
- label “Nicotinate metabolism”

NAD+ synthase activity `http://purl.obolibrary.org/obo/GO_0008795`

Removed

NAD+ synthase activity definition “Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+.”
- database_cross_reference “EC:6.3.1.5”

Added

NAD+ synthase activity definition “Catalysis of the reaction: deamido-NAD+ + NH4+ + ATP = AMP + diphosphate + NAD+ + H+.”
- database_cross_reference “RHEA:21188”

NAD-dependent protein lysine deacylase activity `http://purl.obolibrary.org/obo/GO_0141218`

Added

NADH dehydrogenase (menaquinone) (non-electrogenic) activity `http://purl.obolibrary.org/obo/GO_0103036`

Added

NADH dehydrogenase (quinone) (non-electrogenic) activity `http://purl.obolibrary.org/obo/GO_0050136`

Added

NADH dehydrogenase (ubiquinone) activity `http://purl.obolibrary.org/obo/GO_0008137`

Removed

NADH dehydrogenase (ubiquinone) activity SubClassOf has part some oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
NADH dehydrogenase (ubiquinone) activity SubClassOf has part some NADH dehydrogenase activity

Added

NADH dehydrogenase (ubiquinone) activity term tracker item “https://github.com/geneontology/go-ontology/issues/25935”^^anyURI
NADH dehydrogenase (ubiquinone) activity SubClassOf oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
NADH dehydrogenase (ubiquinone) activity SubClassOf NADH dehydrogenase activity

NADH dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0003954`

Added

NADH dehydrogenase activity narrowMatch 47524
NADH dehydrogenase activity database_cross_reference “RHEA:30147”
NADH dehydrogenase activity database_cross_reference “RHEA:47524”
NADH dehydrogenase activity narrowMatch 30147

NADPH dehydrogenase (quinone) activity `http://purl.obolibrary.org/obo/GO_0008753`

Added

NADPH dehydrogenase (quinone) activity database_cross_reference “RHEA:61980”
NADPH dehydrogenase (quinone) activity narrowMatch 63492
NADPH dehydrogenase (quinone) activity database_cross_reference “RHEA:63492”
NADPH dehydrogenase (quinone) activity narrowMatch 61980
NADPH dehydrogenase (quinone) activity narrowMatch 83239
NADPH dehydrogenase (quinone) activity database_cross_reference “RHEA:83239”

NADPH dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0003959`

Added

NADPH dehydrogenase activity narrowMatch 30151
NADPH dehydrogenase activity database_cross_reference “RHEA:30151”

NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity `http://purl.obolibrary.org/obo/GO_0160246`

Added

NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity database_cross_reference “Reactome:R-HSA-2564824”
- label “NADPH reduces NDOR1:CIAPIN1”

Notch signaling pathway `http://purl.obolibrary.org/obo/GO_0007219`

Removed

Notch signaling pathway definition “The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:signaling”

Added

Notch signaling pathway definition “The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:signaling”

O-phospho-L-serine:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0004648`

Removed

O-phospho-L-serine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.”
- database_cross_reference “EC:2.6.1.52”
O-phospho-L-serine:2-oxoglutarate transaminase activity label “O-phospho-L-serine:2-oxoglutarate aminotransferase activity”

Added

O-phospho-L-serine:2-oxoglutarate transaminase activity has_exact_synonym “O-phospho-L-serine:2-oxoglutarate aminotransferase activity”
O-phospho-L-serine:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
O-phospho-L-serine:2-oxoglutarate transaminase activity label “O-phospho-L-serine:2-oxoglutarate transaminase activity”
O-phospho-L-serine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.”
- database_cross_reference “RHEA:14329”

O-sialoglycoprotein catabolic process `http://purl.obolibrary.org/obo/GO_0045173`

Removed

O-sialoglycoprotein catabolic process definition “The chemical reactions and pathways resulting in the breakdown of O-sialoglycoproteins, glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:8824323”

Added

O-sialoglycoprotein catabolic process definition “The chemical reactions and pathways resulting in the breakdown of O-sialoglycoproteins, glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:8824323”

P-type divalent copper transporter activity `http://purl.obolibrary.org/obo/GO_0043682`

Removed

P-type divalent copper transporter activity database_cross_reference “Reactome:R-HSA-6803545”
- label “ATP7A transports cytosolic Cu2+ to phagosomal lumen”
P-type divalent copper transporter activity database_cross_reference “Reactome:R-HSA-3697838”
- label “ATP7A transfers Cu from ATOX1 to SOD3”
P-type divalent copper transporter activity database_cross_reference “Reactome:R-HSA-936802”
- label “ATP7A transports cytosolic Cu2+ to extracellular region”
P-type divalent copper transporter activity database_cross_reference “Reactome:R-HSA-936895”
- label “ATP7B transports cytosolic Cu2+ to Golgi lumen”

P-type monovalent copper transporter activity `http://purl.obolibrary.org/obo/GO_0140581`

Added

P-type monovalent copper transporter activity database_cross_reference “Reactome:R-HSA-3697838”
- label “ATP7A transfers Cu from ATOX1 to SOD3”
P-type monovalent copper transporter activity database_cross_reference “Reactome:R-HSA-6803545”
- label “ATP7A transports cytosolic Cu2+ to phagosomal lumen”
P-type monovalent copper transporter activity database_cross_reference “Reactome:R-HSA-936895”
- label “ATP7B transports cytosolic Cu1+ to Golgi lumen”
P-type monovalent copper transporter activity database_cross_reference “Reactome:R-HSA-936802”
- label “ATP7A transports cytosolic Cu1+ to extracellular region”

PDZ domain binding `http://purl.obolibrary.org/obo/GO_0030165`

Removed

PDZ domain binding definition “Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins.”
- database_cross_reference “Pfam:PF00595”
- database_cross_reference “GOC:go_curators”

Added

PDZ domain binding definition “Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins.”
- database_cross_reference “Pfam:PF00595”
- database_cross_reference “GOC:curators”

RADAR pathway `http://purl.obolibrary.org/obo/GO_0170074`

Added

RADAR pathway created by “ew”
RADAR pathway definition “A quality control pathway that degrades peroxisomal matrix protein receptors when the recycling machinery is blocked. When recycling to the cytosol fails, cargo-free receptors accumulate at the peroxisomal membrane, where they are polyubiquitinated and subsequently degraded by the ubiquitin-proteasome system (UPS).”
- database_cross_reference “PMID:16390998”
- database_cross_reference “PMID:41076631”
- database_cross_reference “PMID:17011644”
RADAR pathway creation date “2026-02-17T22:02:27Z”
RADAR pathway has_exact_synonym “Receptor Accumulation and Degradation in the Absence of Recycling”
RADAR pathway term tracker item “https://github.com/geneontology/go-ontology/issues/31570”^^anyURI
RADAR pathway id “GO:0170074”
RADAR pathway label “RADAR pathway”
RADAR pathway has_obo_namespace “biological_process”
Class: RADAR pathway
RADAR pathway SubClassOf proteasome-mediated ubiquitin-dependent protein catabolic process

RNA 2’,3’-cyclic phosphatase activity `http://purl.obolibrary.org/obo/GO_0160272`

Removed

RNA 2’,3’-cyclic phosphatase activity definition “Catalysis of the reaction: a 3’-end 2’,3’-cyclophospho-ribonucleotide-RNA + 2 H2O = a 3’-end ribonucleotide-RNA + phosphate + H+.”
- database_cross_reference “PMID:32732418”

Added

RNA 2’,3’-cyclic phosphatase activity definition “Catalysis of the reaction: a 3’-end 2’,3’-cyclophospho-ribonucleotide-RNA + 2 H2O = a 3’-end ribonucleotide-RNA + phosphate + H+.”
- database_cross_reference “RHEA:85011”
- database_cross_reference “PMID:32732418”
RNA 2’,3’-cyclic phosphatase activity database_cross_reference “RHEA:85011”
RNA 2’,3’-cyclic phosphatase activity exactMatch 85011

RNA 2’-O-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0062105`

Added

RNA 2’-O-methyltransferase activity database_cross_reference “RHEA:65380”
RNA 2’-O-methyltransferase activity narrowMatch 56884
RNA 2’-O-methyltransferase activity database_cross_reference “RHEA:56884”
RNA 2’-O-methyltransferase activity database_cross_reference “RHEA:42724”
RNA 2’-O-methyltransferase activity narrowMatch 48628
RNA 2’-O-methyltransferase activity database_cross_reference “RHEA:48628”
RNA 2’-O-methyltransferase activity narrowMatch 42724
RNA 2’-O-methyltransferase activity narrowMatch 65380

RNA 2’-phosphatase activity `http://purl.obolibrary.org/obo/GO_0160273`

Removed

RNA 2’-phosphatase activity definition “Catalysis of the reaction: H2O + a 3’-end 2’-phospho-ribonucleotide-RNA = a 3’-end ribonucleotide-RNA + phosphate.”
- database_cross_reference “PMID:36180430”

Added

RNA 2’-phosphatase activity database_cross_reference “RHEA:85191”
RNA 2’-phosphatase activity exactMatch 85191
RNA 2’-phosphatase activity definition “Catalysis of the reaction: H2O + a 3’-end 2’-phospho-ribonucleotide-RNA = a 3’-end ribonucleotide-RNA + phosphate.”
- database_cross_reference “PMID:36180430”
- database_cross_reference “RHEA:85191”

RNA catabolic process `http://purl.obolibrary.org/obo/GO_0006401`

Added

RNA catabolic process database_cross_reference “Reactome:R-HSA-9930044”
- label “Nuclear RNA decay”

RNA endonuclease activity `http://purl.obolibrary.org/obo/GO_0004521`

Added

RNA endonuclease activity database_cross_reference “Reactome:R-HSA-9948427”
- label “ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide”

RNA exonuclease activity, producing 5’-phosphomonoesters `http://purl.obolibrary.org/obo/GO_0016896`

Added

RNA exonuclease activity, producing 5’-phosphomonoesters database_cross_reference “Reactome:R-HSA-9946784”
- label “DENV mRNA is decapped”

RNA import into mitochondrion `http://purl.obolibrary.org/obo/GO_0035927`

Added

RNA import into mitochondrion SubClassOf intercellular transport

RNA methylation `http://purl.obolibrary.org/obo/GO_0001510`

Added

RNA methylation term tracker item “https://github.com/geneontology/go-ontology/issues/27423”^^anyURI
RNA methylation in_subset gocheck_obsoletion_candidate

RNA modification `http://purl.obolibrary.org/obo/GO_0009451`

Removed

RNA modification definition “The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:1555811337”

Added

RNA modification definition “The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:1555811337”

RNA polymerase II cis-regulatory region sequence-specific DNA binding `http://purl.obolibrary.org/obo/GO_0000978`

Added

RNA polymerase II cis-regulatory region sequence-specific DNA binding database_cross_reference “Reactome:R-HSA-400204”
- label “PPARA binds RXRA”

RNA polymerase II complex binding `http://purl.obolibrary.org/obo/GO_0000993`

Removed

RNA polymerase II complex binding SubClassOf obsolete basal RNA polymerase II transcription machinery binding

RNA polymerase II general transcription initiation factor binding `http://purl.obolibrary.org/obo/GO_0001091`

Removed

RNA polymerase II general transcription initiation factor binding SubClassOf obsolete basal RNA polymerase II transcription machinery binding

Added

RNA polymerase II general transcription initiation factor binding SubClassOf RNA polymerase II complex binding

RNA polymerase III general transcription initiation factor activity `http://purl.obolibrary.org/obo/GO_0000995`

Removed

RNA polymerase III general transcription initiation factor activity definition “A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC. RNA polymerase III transcribes genes encoding short RNAs, including tRNAs, 5S rRNA, U6 snRNA, the short ncRNA component of RNases P, the mitochondrial RNA processing (MRP) RNA, the signal recognition particle SRP RNA, and in higher eukaryotes a number of micro and other small RNAs, though there is some variability across species as to whether a given small noncoding RNA is transcribed by RNA polymerase II or RNA polymerase III.”
- database_cross_reference “GOC:txnOH-2018”
- database_cross_reference “PMID:20413673”
- database_cross_reference “Wikipedia:RNA_polymerase_III”
- database_cross_reference “PMID:17977614”
- database_cross_reference “PMID:27068803”
- database_cross_reference “PMID:12381659”

Added

RNA polymerase III general transcription initiation factor activity term tracker item “https://github.com/geneontology/go-ontology/issues/15862”^^anyURI
RNA polymerase III general transcription initiation factor activity definition “A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC. RNA polymerase III transcribes genes encoding short RNAs, including tRNAs, 5S rRNA, U6 snRNA, the short ncRNA component of RNases P, the mitochondrial RNA processing (MRP) RNA, the signal recognition particle SRP RNA, and in higher eukaryotes a number of micro and other small RNAs, though there is some variability across species as to whether a given small noncoding RNA is transcribed by RNA polymerase II or RNA polymerase III.”
- database_cross_reference “GOC:txnOH-2018”
- database_cross_reference “PMID:20413673”
- database_cross_reference “Wikipedia:RNA_polymerase_III”
- database_cross_reference “PMID:17977614”
- database_cross_reference “PMID:40762516”
- database_cross_reference “PMID:27068803”
- database_cross_reference “PMID:12381659”

RNA stabilization `http://purl.obolibrary.org/obo/GO_0043489`

Removed

RNA stabilization definition “Prevention of degradation of RNA molecules.”
- database_cross_reference “GOC:go_curators”

Added

RNA stabilization definition “Prevention of degradation of RNA molecules.”
- database_cross_reference “GOC:curators”

RNA-DNA hybrid ribonuclease activity `http://purl.obolibrary.org/obo/GO_0004523`

Added

RNA-DNA hybrid ribonuclease activity database_cross_reference “Reactome:R-HSA-9914858”
- label “RNASEH1 cleaves RNA primer from nascent H strand, leaving RNA dinucleotides”
RNA-DNA hybrid ribonuclease activity database_cross_reference “Reactome:R-HSA-9915449”
- label “RNASEH1 cleaves RNA primer from nascent L strand, leaving RNA dinucleotides”
RNA-DNA hybrid ribonuclease activity database_cross_reference “Reactome:R-HSA-9913637”
- label “RNASEH1 cleaves R-loop RNA to yield RNA primer for H strand polymerization”

RNA-directed RNA polymerase activity `http://purl.obolibrary.org/obo/GO_0003968`

Added

RNA-directed RNA polymerase activity database_cross_reference “Reactome:R-HSA-9922955”
- label “NS5 synthesizes minus strand genome”
RNA-directed RNA polymerase activity database_cross_reference “Reactome:R-HSA-9923068”
- label “NS5 synthesizes plus strand genome”

S-adenosyl-L-methionine:8-amino-7-oxononanoate transaminase activity `http://purl.obolibrary.org/obo/GO_0004015`

Removed

S-adenosyl-L-methionine:8-amino-7-oxononanoate transaminase activity label “adenosylmethionine-8-amino-7-oxononanoate transaminase activity”
S-adenosyl-L-methionine:8-amino-7-oxononanoate transaminase activity definition “Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate.”
- database_cross_reference “EC:2.6.1.62”
- database_cross_reference “RHEA:16861”

Added

S-adenosyl-L-methionine:8-amino-7-oxononanoate transaminase activity has_exact_synonym “adenosylmethionine-8-amino-7-oxononanoate transaminase activity”
S-adenosyl-L-methionine:8-amino-7-oxononanoate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
S-adenosyl-L-methionine:8-amino-7-oxononanoate transaminase activity definition “Catalysis of the reaction: (8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = S-adenosyl-4-methylsulfanyl-2-oxobutanoate + (7R,8S)-7,8-diammoniononanoate.”
- database_cross_reference “RHEA:16861”
S-adenosyl-L-methionine:8-amino-7-oxononanoate transaminase activity label “S-adenosyl-L-methionine:8-amino-7-oxononanoate transaminase activity”

S-adenosylmethionine biosynthetic process `http://purl.obolibrary.org/obo/GO_0006556`

Removed

S-adenosylmethionine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5’-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

S-adenosylmethionine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5’-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

S-adenosylmethionine metabolic process `http://purl.obolibrary.org/obo/GO_0046500`

Removed

S-adenosylmethionine metabolic process definition “The chemical reactions and pathways involving S-adenosylmethionine, S-(5’-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

S-adenosylmethionine metabolic process definition “The chemical reactions and pathways involving S-adenosylmethionine, S-(5’-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

S-methyl-5-thioribose-1-phosphate isomerase activity `http://purl.obolibrary.org/obo/GO_0046523`

Removed

S-methyl-5-thioribose-1-phosphate isomerase activity database_cross_reference “Reactome:R-HSA-1299507”
- label “Methylthio-ribulose-P = Methylthio-ribose-P”
S-methyl-5-thioribose-1-phosphate isomerase activity database_cross_reference “Reactome:R-HSA-1237096”
- label “Methylthio-ribose-P = Methylthio-ribulose-P”

Added

S-methyl-5-thioribose-1-phosphate isomerase activity database_cross_reference “Reactome:R-HSA-1299507”
- label “Methylthio-ribulose-P => Methylthio-ribose-P”
S-methyl-5-thioribose-1-phosphate isomerase activity database_cross_reference “Reactome:R-HSA-1237096”
- label “Methylthio-ribose-P => Methylthio-ribulose-P”

SH2 domain binding `http://purl.obolibrary.org/obo/GO_0042169`

Removed

SH2 domain binding definition “Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “Pfam:PF00017”

Added

SH2 domain binding definition “Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.”
- database_cross_reference “GOC:curators”
- database_cross_reference “Pfam:PF00017”

SH3 domain binding `http://purl.obolibrary.org/obo/GO_0017124`

Removed

SH3 domain binding definition “Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “Pfam:PF00018”

Added

SH3 domain binding definition “Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.”
- database_cross_reference “GOC:curators”
- database_cross_reference “Pfam:PF00018”

SNAP receptor activity `http://purl.obolibrary.org/obo/GO_0005484`

Added

SNAP receptor activity term tracker item “https://github.com/geneontology/go-ontology/issues/31564”^^anyURI
SNAP receptor activity SubClassOf part of some fusogenic activity

SUMO transferase activity `http://purl.obolibrary.org/obo/GO_0019789`

Added

SUMO transferase activity database_cross_reference “Reactome:R-HSA-9920126”
- label “UBC9 SUMOylates NS5”
SUMO transferase activity database_cross_reference “Reactome:R-HSA-9926476”
- label “UBE2I sumoylates MITF-M”

T cell costimulation `http://purl.obolibrary.org/obo/GO_0031295`

Removed

T cell costimulation database_cross_reference “Reactome:R-HSA-388841”
- label “Costimulation by the CD28 family”

Added

T cell costimulation database_cross_reference “Reactome:R-HSA-388841”
- label “Regulation of T cell activation by CD28 family”

T cell differentiation `http://purl.obolibrary.org/obo/GO_0030217`

Added

T cell differentiation database_cross_reference “Reactome:R-HSA-9945266”
- label “Differentiation of T cells”

T-helper 1 cell differentiation `http://purl.obolibrary.org/obo/GO_0045063`

Added

T-helper 1 cell differentiation database_cross_reference “Reactome:R-HSA-9942503”
- label “Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)”

TDP metabolic process `http://purl.obolibrary.org/obo/GO_0046043`

Removed

TDP metabolic process definition “The chemical reactions and pathways involving TDP, ribosylthymine diphosphate.”
- database_cross_reference “GOC:go_curators”

Added

TDP metabolic process definition “The chemical reactions and pathways involving TDP, ribosylthymine diphosphate.”
- database_cross_reference “GOC:curators”

TFIIA-class transcription factor complex binding `http://purl.obolibrary.org/obo/GO_0001092`

Removed

TFIIA-class transcription factor complex binding SubClassOf protein-containing complex binding

TFIID-class transcription factor complex binding `http://purl.obolibrary.org/obo/GO_0001094`

Removed

TFIID-class transcription factor complex binding SubClassOf protein-containing complex binding

TFIIE-class transcription factor complex binding `http://purl.obolibrary.org/obo/GO_0001095`

Removed

TFIIE-class transcription factor complex binding SubClassOf protein-containing complex binding

TFIIF-class transcription factor complex binding `http://purl.obolibrary.org/obo/GO_0001096`

Removed

TFIIF-class transcription factor complex binding SubClassOf protein-containing complex binding

TFIIH-class transcription factor complex binding `http://purl.obolibrary.org/obo/GO_0001097`

Removed

TFIIH-class transcription factor complex binding SubClassOf protein-containing complex binding

TMP catabolic process `http://purl.obolibrary.org/obo/GO_0046045`

Removed

TMP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of TMP, ribosylthymine monophosphate.”
- database_cross_reference “GOC:go_curators”

Added

TMP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of TMP, ribosylthymine monophosphate.”
- database_cross_reference “GOC:curators”

TMP metabolic process `http://purl.obolibrary.org/obo/GO_0046044`

Removed

TMP metabolic process definition “The chemical reactions and pathways involving TMP, ribosylthymine monophosphate.”
- database_cross_reference “GOC:go_curators”

Added

TMP metabolic process definition “The chemical reactions and pathways involving TMP, ribosylthymine monophosphate.”
- database_cross_reference “GOC:curators”

TRAIL binding `http://purl.obolibrary.org/obo/GO_0045569`

Removed

TRAIL binding definition “Binding to TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:9082980”

Added

TRAIL binding definition “Binding to TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:9082980”

TTP catabolic process `http://purl.obolibrary.org/obo/GO_0046047`

Removed

TTP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of TTP, ribosylthymine triphosphate.”
- database_cross_reference “GOC:go_curators”

Added

TTP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of TTP, ribosylthymine triphosphate.”
- database_cross_reference “GOC:curators”

TTP metabolic process `http://purl.obolibrary.org/obo/GO_0046046`

Removed

TTP metabolic process definition “The chemical reactions and pathways involving TTP, ribosylthymine triphosphate.”
- database_cross_reference “GOC:go_curators”

Added

TTP metabolic process definition “The chemical reactions and pathways involving TTP, ribosylthymine triphosphate.”
- database_cross_reference “GOC:curators”

Toll signaling pathway `http://purl.obolibrary.org/obo/GO_0008063`

Removed

Toll signaling pathway definition “The series of molecular signals initiated by an extracellular ligand binding to the receptor Toll on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.”
- database_cross_reference “PMID:11135568”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:19126860”

Added

Toll signaling pathway definition “The series of molecular signals initiated by an extracellular ligand binding to the receptor Toll on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:11135568”
- database_cross_reference “PMID:19126860”

U2 snRNA (2’-O-methyladenosine-N6)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0106347`

Removed

U2 snRNA (2’-O-methyladenosine-N6)-methyltransferase activity definition “Catalysis of the reaction: a 2’-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine = an N6-methyl-2’-O-methyladenosine in U2 snRNA + S-adenosyl-L-homocysteine + H+.”
- database_cross_reference “PMID:31913360”
- database_cross_reference “RHEA:62672”
U2 snRNA (2’-O-methyladenosine-N6)-methyltransferase activity label “U2 snRNA 2’-O-methyladenosine m6 methyltransferase activity”

Added

U2 snRNA (2’-O-methyladenosine-N6)-methyltransferase activity has_exact_synonym “U2 snRNA (2’-O-methyladenosine) m6 methyltransferase activity”
U2 snRNA (2’-O-methyladenosine-N6)-methyltransferase activity definition “Catalysis of the reaction: a 2’-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine = an N6-methyl-2’-O-methyladenosine in U2 snRNA + S-adenosyl-L-homocysteine + H+; methylates the 6th position of adenine residues with a pre-deposited 2’-O-methylation.”
- database_cross_reference “PMID:31913360”
- database_cross_reference “RHEA:62672”
U2 snRNA (2’-O-methyladenosine-N6)-methyltransferase activity label “U2 snRNA (2’-O-methyladenosine-N6)-methyltransferase activity”

U2 snRNA (adenine-N6)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0106348`

Removed

U2 snRNA (adenine-N6)-methyltransferase activity label “U2 snRNA adenosine m6 methyltransferase activity”

Added

U2 snRNA (adenine-N6)-methyltransferase activity label “U2 snRNA (adenine-N6)-methyltransferase activity”
U2 snRNA (adenine-N6)-methyltransferase activity has_exact_synonym “U2 snRNA adenosine m6 methyltransferase activity”
U2 snRNA (adenine-N6)-methyltransferase activity has_exact_synonym “U2 snRNA adenosine N6 methyltransferase activity”

U6 snRNA (adenine(43)-N6)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0120048`

Removed

U6 snRNA (adenine(43)-N6)-methyltransferase activity label “U6 snRNA (adenine-(43)-N(6))-methyltransferase activity”

Added

U6 snRNA (adenine(43)-N6)-methyltransferase activity has_exact_synonym “U6 snRNA m(6)A methyltransferase activity”
U6 snRNA (adenine(43)-N6)-methyltransferase activity label “U6 snRNA (adenine(43)-N6)-methyltransferase activity”

UDP metabolic process `http://purl.obolibrary.org/obo/GO_0046048`

Removed

UDP metabolic process definition “The chemical reactions and pathways involving UDP, uridine (5’-)diphosphate.”
- database_cross_reference “GOC:go_curators”

Added

UDP metabolic process definition “The chemical reactions and pathways involving UDP, uridine (5’-)diphosphate.”
- database_cross_reference “GOC:curators”

UDP-3-O-[(3R)-3-hydroxyacyl]-glucosamine N-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0103118`

Added

UDP-3-O-acyl-N-acetylglucosamine deacetylase activity `http://purl.obolibrary.org/obo/GO_0103117`

Added

UDP-4-amino-4-deoxy-L-arabinose:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0099620`

Removed

UDP-4-amino-4-deoxy-L-arabinose:2-oxoglutarate transaminase activity label “UDP-4-amino-4-deoxy-L-arabinose aminotransferase activity”

Added

UDP-4-amino-4-deoxy-L-arabinose:2-oxoglutarate transaminase activity label “UDP-4-amino-4-deoxy-L-arabinose:2-oxoglutarate transaminase activity”
UDP-4-amino-4-deoxy-L-arabinose:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
UDP-4-amino-4-deoxy-L-arabinose:2-oxoglutarate transaminase activity has_broad_synonym “UDP-4-amino-4-deoxy-L-arabinose aminotransferase”

UDP-D-galacturonate biosynthetic process `http://purl.obolibrary.org/obo/GO_0033480`

Added

UDP-D-galacturonate biosynthetic process narrowMatch PWY-4
UDP-D-galacturonate biosynthetic process database_cross_reference “MetaCyc:PWY-4861”
UDP-D-galacturonate biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI
UDP-D-galacturonate biosynthetic process narrowMatch PWY-4861

UDP-N-acetylbacillosamine:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0047302`

Removed

UDP-N-acetylbacillosamine:2-oxoglutarate transaminase activity label “UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase activity”
UDP-N-acetylbacillosamine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + UDP-2-acetamido-4-amino-2,4,6-trideoxy-D-glucose = L-glutamate + UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose.”
- database_cross_reference “RHEA:31663”
- database_cross_reference “PMID:16286454”

Added

UDP-N-acetylbacillosamine:2-oxoglutarate transaminase activity label “UDP-N-acetylbacillosamine:2-oxoglutarate transaminase activity”
UDP-N-acetylbacillosamine:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
UDP-N-acetylbacillosamine:2-oxoglutarate transaminase activity has_broad_synonym “UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase activity”
UDP-N-acetylbacillosamine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: UDP-N-acetylbacillosamine + 2-oxoglutarate = UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose + L-glutamate.”
- database_cross_reference “RHEA:31663”
- database_cross_reference “PMID:16286454”

UDP-N-acetylgalactosamine biosynthetic process `http://purl.obolibrary.org/obo/GO_0019277`

Added

UDP-N-acetylgalactosamine biosynthetic process narrowMatch PWY-5512
UDP-N-acetylgalactosamine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI
UDP-N-acetylgalactosamine biosynthetic process database_cross_reference “MetaCyc:PWY-5512”

UDP-N-acetylglucosamine 4-epimerase activity `http://purl.obolibrary.org/obo/GO_0003974`

Removed

UDP-N-acetylglucosamine 4-epimerase activity comment “Note that this term has a MetaCyc pathway reference as the pathway only has a single step.”
UDP-N-acetylglucosamine 4-epimerase activity relatedMatch PWY-5512

Added

UDP-N-acetylglucosamine 4-epimerase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI

UDP-glucose:4-aminobenzoate acylglucosyltransferase activity `http://purl.obolibrary.org/obo/GO_0080002`

Removed

UDP-glucose:4-aminobenzoate acylglucosyltransferase activity definition “Catalysis of the reaction: 4-aminobenzoate + UDP-alpha-D-glucose = 1-O-(4-aminobenzoyl)-beta-D-glucose + UDP.”
- database_cross_reference “PMID:18385129”

Added

UDP-glucose:4-aminobenzoate acylglucosyltransferase activity database_cross_reference “RHEA:85851”
UDP-glucose:4-aminobenzoate acylglucosyltransferase activity exactMatch 85851
UDP-glucose:4-aminobenzoate acylglucosyltransferase activity definition “Catalysis of the reaction: 4-aminobenzoate + UDP-alpha-D-glucose = 1-O-(4-aminobenzoyl)-beta-D-glucose + UDP.”
- database_cross_reference “RHEA:85851”
- database_cross_reference “PMID:18385129”

UDP-glucuronate 4-epimerase activity `http://purl.obolibrary.org/obo/GO_0050378`

Removed

UDP-glucuronate 4-epimerase activity definition “Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate.”
- database_cross_reference “RHEA:11404”
- database_cross_reference “EC:5.1.3.6”
UDP-glucuronate 4-epimerase activity relatedMatch PWY-4861
UDP-glucuronate 4-epimerase activity comment “Note that this term has a MetaCyc pathway reference as the pathway only has a single step.”

Added

UDP-glucuronate 4-epimerase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI
UDP-glucuronate 4-epimerase activity definition “Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate.”
- database_cross_reference “RHEA:11404”

UDP-xylosyltransferase activity `http://purl.obolibrary.org/obo/GO_0035252`

Removed

UDP-xylosyltransferase activity database_cross_reference “Reactome:R-HSA-9638090”
- label “B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA”
UDP-xylosyltransferase activity database_cross_reference “Reactome:R-HSA-5617138”
- label “B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA”

Added

UDP-xylosyltransferase activity database_cross_reference “Reactome:R-HSA-9638090”
- label “LARGE1,2 elongates matriglycan chain with Xyl”

UMP catabolic process `http://purl.obolibrary.org/obo/GO_0046050`

Removed

UMP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of UMP, uridine monophosphate.”
- database_cross_reference “GOC:go_curators”

Added

UMP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of UMP, uridine monophosphate.”
- database_cross_reference “GOC:curators”

UMP metabolic process `http://purl.obolibrary.org/obo/GO_0046049`

Removed

UMP metabolic process definition “The chemical reactions and pathways involving UMP, uridine monophosphate.”
- database_cross_reference “GOC:go_curators”

Added

UMP metabolic process definition “The chemical reactions and pathways involving UMP, uridine monophosphate.”
- database_cross_reference “GOC:curators”

UTP catabolic process `http://purl.obolibrary.org/obo/GO_0046052`

Removed

UTP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of UTP, uridine (5’-)triphosphate.”
- database_cross_reference “GOC:go_curators”

Added

UTP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of UTP, uridine (5’-)triphosphate.”
- database_cross_reference “GOC:curators”

UTP metabolic process `http://purl.obolibrary.org/obo/GO_0046051`

Removed

UTP metabolic process definition “The chemical reactions and pathways involving UTP, uridine (5’-)triphosphate.”
- database_cross_reference “GOC:go_curators”

Added

UTP metabolic process definition “The chemical reactions and pathways involving UTP, uridine (5’-)triphosphate.”
- database_cross_reference “GOC:curators”

UTP:glucose-1-phosphate uridylyltransferase activity `http://purl.obolibrary.org/obo/GO_0003983`

Removed

UTP:glucose-1-phosphate uridylyltransferase activity database_cross_reference “Reactome:R-HSA-70286”
- label “UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose”

Added

UTP:glucose-1-phosphate uridylyltransferase activity database_cross_reference “Reactome:R-HSA-70286”
- label “UTP + D-glucose 1-phosphate => pyrophosphate + UDP-glucose”

Wnt receptor activity `http://purl.obolibrary.org/obo/GO_0042813`

Removed

Wnt receptor activity definition “Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.”
- database_cross_reference “GOC:go_curators”

Added

Wnt receptor activity definition “Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.”
- database_cross_reference “GOC:curators”

[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity `http://purl.obolibrary.org/obo/GO_0047323`

Removed

[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity database_cross_reference “Reactome:R-HSA-5693148”
- label “BCKDK phosphorylates BCKDH”

[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity `http://purl.obolibrary.org/obo/GO_0047385`

Added

[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity database_cross_reference “Reactome:R-HSA-5693153”
- label “PPM1K dephosphorylates p-BCKDH”

[heparan sulfate]-glucosamine 3-sulfotransferase activity `http://purl.obolibrary.org/obo/GO_0008467`

Removed

[heparan sulfate]-glucosamine 3-sulfotransferase activity database_cross_reference “Reactome:R-HSA-2076611”
- label “HS3STs sulfate GlcN at C3 in heparan sulfate”

Added

[heparan sulfate]-glucosamine 3-sulfotransferase activity database_cross_reference “Reactome:R-HSA-2076611”
- label “HS3ST2-6 sulfate GlcN at C3 in heparan sulfate”

[protein]-asparagine 3-dioxygenase activity `http://purl.obolibrary.org/obo/GO_0036140`

Added

[protein]-asparagine 3-dioxygenase activity database_cross_reference “RHEA:54268”
[protein]-asparagine 3-dioxygenase activity narrowMatch 54268
[protein]-asparagine 3-dioxygenase activity database_cross_reference “RHEA:54272”
[protein]-asparagine 3-dioxygenase activity narrowMatch 54272

absorption of UV light `http://purl.obolibrary.org/obo/GO_0016039`

Removed

absorption of UV light definition “The reception of a (UV light) photon by a cell, UV light being defined as having a wavelength within the range 13.6-400 nm.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

absorption of UV light definition “The reception of a (UV light) photon by a cell, UV light being defined as having a wavelength within the range 13.6-400 nm.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

absorption of visible light `http://purl.obolibrary.org/obo/GO_0016038`

Removed

absorption of visible light definition “The reception of a (visible light) photon by a cell, visible light being defined as having a wavelength within the range 380-780 nm.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

absorption of visible light definition “The reception of a (visible light) photon by a cell, visible light being defined as having a wavelength within the range 380-780 nm.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

acetaldehyde metabolic process `http://purl.obolibrary.org/obo/GO_0006117`

Removed

acetaldehyde metabolic process definition “The chemical reactions and pathways involving acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol.”
- database_cross_reference “GOC:go_curators”

Added

acetaldehyde metabolic process definition “The chemical reactions and pathways involving acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol.”
- database_cross_reference “GOC:curators”

acetate biosynthetic process `http://purl.obolibrary.org/obo/GO_0019413`

Removed

acetate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid.”
- database_cross_reference “GOC:go_curators”

Added

acetate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid.”
- database_cross_reference “GOC:curators”

acetate biosynthetic process from carbon monoxide `http://purl.obolibrary.org/obo/GO_0019415`

Removed

acetate biosynthetic process from carbon monoxide definition “The chemical reactions and pathways resulting in the formation of acetate from other compounds, including carbon monoxide.”
- database_cross_reference “GOC:go_curators”

Added

acetate biosynthetic process from carbon monoxide definition “The chemical reactions and pathways resulting in the formation of acetate from other compounds, including carbon monoxide.”
- database_cross_reference “GOC:curators”

acetate catabolic process `http://purl.obolibrary.org/obo/GO_0045733`

Removed

acetate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid.”
- database_cross_reference “GOC:go_curators”

Added

acetate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid.”
- database_cross_reference “GOC:curators”

acetate metabolic process `http://purl.obolibrary.org/obo/GO_0006083`

Removed

acetate metabolic process definition “The chemical reactions and pathways involving acetate, the anion of acetic acid.”
- database_cross_reference “GOC:go_curators”

Added

acetate metabolic process definition “The chemical reactions and pathways involving acetate, the anion of acetic acid.”
- database_cross_reference “GOC:curators”

acetate-CoA ligase (ADP-forming) activity `http://purl.obolibrary.org/obo/GO_0043758`

Removed

acetate-CoA ligase (ADP-forming) activity SubClassOf acid-thiol ligase activity

Added

acetate-CoA ligase (ADP-forming) activity SubClassOf CoA-ligase activity

acetoacetate-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0030729`

Removed

acetoacetate-CoA ligase activity SubClassOf acid-thiol ligase activity

acetoacetyl-CoA reductase activity `http://purl.obolibrary.org/obo/GO_0018454`

Added

acetoacetyl-CoA reductase activity narrowMatch 39171
acetoacetyl-CoA reductase activity narrowMatch 39447
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39407”
acetoacetyl-CoA reductase activity narrowMatch 39531
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39543”
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39459”
acetoacetyl-CoA reductase activity narrowMatch 39599
acetoacetyl-CoA reductase activity narrowMatch 39371
acetoacetyl-CoA reductase activity narrowMatch 39435
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39183”
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:45844”
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39447”
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39371”
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:45848”
acetoacetyl-CoA reductase activity narrowMatch 39395
acetoacetyl-CoA reductase activity narrowMatch 39339
acetoacetyl-CoA reductase activity narrowMatch 39243
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39531”
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39507”
acetoacetyl-CoA reductase activity narrowMatch 39163
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39599”
acetoacetyl-CoA reductase activity narrowMatch 39495
acetoacetyl-CoA reductase activity narrowMatch 39459
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39299”
acetoacetyl-CoA reductase activity narrowMatch 39219
acetoacetyl-CoA reductase activity narrowMatch 39407
acetoacetyl-CoA reductase activity narrowMatch 39151
acetoacetyl-CoA reductase activity narrowMatch 39543
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39311”
acetoacetyl-CoA reductase activity narrowMatch 45848
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39231”
acetoacetyl-CoA reductase activity narrowMatch 39207
acetoacetyl-CoA reductase activity narrowMatch 45844
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39339”
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39335”
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39359”
acetoacetyl-CoA reductase activity narrowMatch 39183
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39323”
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39151”
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39471”
acetoacetyl-CoA reductase activity narrowMatch 39231
acetoacetyl-CoA reductase activity narrowMatch 39359
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39519”
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39483”
acetoacetyl-CoA reductase activity narrowMatch 39555
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39555”
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39171”
acetoacetyl-CoA reductase activity narrowMatch 45796
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39575”
acetoacetyl-CoA reductase activity narrowMatch 39471
acetoacetyl-CoA reductase activity narrowMatch 39383
acetoacetyl-CoA reductase activity narrowMatch 39483
acetoacetyl-CoA reductase activity narrowMatch 39195
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39219”
acetoacetyl-CoA reductase activity narrowMatch 39311
acetoacetyl-CoA reductase activity narrowMatch 39335
acetoacetyl-CoA reductase activity narrowMatch 39255
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39207”
acetoacetyl-CoA reductase activity narrowMatch 39323
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39195”
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39435”
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:45796”
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39587”
acetoacetyl-CoA reductase activity narrowMatch 39419
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39383”
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39611”
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39419”
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39163”
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39495”
acetoacetyl-CoA reductase activity narrowMatch 39611
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39395”
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39623”
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39635”
acetoacetyl-CoA reductase activity narrowMatch 39507
acetoacetyl-CoA reductase activity narrowMatch 39635
acetoacetyl-CoA reductase activity narrowMatch 39519
acetoacetyl-CoA reductase activity narrowMatch 39299
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39243”
acetoacetyl-CoA reductase activity narrowMatch 39575
acetoacetyl-CoA reductase activity database_cross_reference “RHEA:39255”
acetoacetyl-CoA reductase activity narrowMatch 39623
acetoacetyl-CoA reductase activity narrowMatch 39587

acetyl-CoA C-acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0003985`

Removed

acetyl-CoA C-acetyltransferase activity database_cross_reference “Reactome:R-HSA-70844”
- label “alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA”

Added

acetyl-CoA C-acetyltransferase activity database_cross_reference “Reactome:R-HSA-70844”
- label “alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA”

acetyl-CoA C-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0003988`

Added

acetyl-CoA C-acyltransferase activity database_cross_reference “RHEA:78899”
acetyl-CoA C-acyltransferase activity narrowMatch 46312
acetyl-CoA C-acyltransferase activity database_cross_reference “RHEA:34799”
acetyl-CoA C-acyltransferase activity narrowMatch 78895
acetyl-CoA C-acyltransferase activity narrowMatch 67224
acetyl-CoA C-acyltransferase activity database_cross_reference “RHEA:67224”
acetyl-CoA C-acyltransferase activity database_cross_reference “RHEA:78903”
acetyl-CoA C-acyltransferase activity narrowMatch 78899
acetyl-CoA C-acyltransferase activity database_cross_reference “RHEA:78895”
acetyl-CoA C-acyltransferase activity database_cross_reference “RHEA:46312”
acetyl-CoA C-acyltransferase activity narrowMatch 34799
acetyl-CoA C-acyltransferase activity narrowMatch 78903
acetyl-CoA C-acyltransferase activity database_cross_reference “RHEA:78907”
acetyl-CoA C-acyltransferase activity narrowMatch 78907

acetyl-CoA biosynthetic process `http://purl.obolibrary.org/obo/GO_0006085`

Removed

acetyl-CoA biosynthetic process definition “The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.”
- database_cross_reference “GOC:go_curators”

Added

acetyl-CoA biosynthetic process database_cross_reference “MetaCyc:PWY-5172”
acetyl-CoA biosynthetic process database_cross_reference “MetaCyc:PWY66-21”
acetyl-CoA biosynthetic process database_cross_reference “MetaCyc:PWY66-161”
acetyl-CoA biosynthetic process narrowMatch ACETATEUTIL-PWY
acetyl-CoA biosynthetic process narrowMatch ETOH-ACETYLCOA-ANA-PWY
acetyl-CoA biosynthetic process definition “The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.”
- database_cross_reference “GOC:curators”
acetyl-CoA biosynthetic process narrowMatch PWY66-21
acetyl-CoA biosynthetic process narrowMatch PWY-5172
acetyl-CoA biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI
acetyl-CoA biosynthetic process narrowMatch PWY66-162
acetyl-CoA biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31666”^^anyURI
acetyl-CoA biosynthetic process narrowMatch PWY66-161
acetyl-CoA biosynthetic process database_cross_reference “MetaCyc:PWY66-162”
acetyl-CoA biosynthetic process database_cross_reference “MetaCyc:ETOH-ACETYLCOA-ANA-PWY”
acetyl-CoA biosynthetic process database_cross_reference “MetaCyc:ACETATEUTIL-PWY”

acetyl-CoA synthetase acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0043894`

Removed

acetyl-CoA synthetase acetyltransferase activity has_related_synonym “Pat”
acetyl-CoA synthetase acetyltransferase activity definition “Catalysis of the acetylation of residue Lys609 of the enzyme acetyl-CoA synthetase, using acetyl-CoA as substrate.”
- database_cross_reference “PMID:15236963”
acetyl-CoA synthetase acetyltransferase activity has_exact_synonym “Pat enzyme”
acetyl-CoA synthetase acetyltransferase activity SubClassOf acetyltransferase activity

Added

acetyl-CoA synthetase acetyltransferase activity has_exact_synonym “acetate CoA ligase acetyltransferase activity”
acetyl-CoA synthetase acetyltransferase activity has_broad_synonym “Pat enzyme”
acetyl-CoA synthetase acetyltransferase activity has_exact_synonym “acetyl CoA synthetase acetyltransferase activity”
acetyl-CoA synthetase acetyltransferase activity has_exact_synonym “acetate-CoA ligase acetyltransferase activity”
acetyl-CoA synthetase acetyltransferase activity definition “Catalysis of the acetylation of a lysine of the enzyme acetyl-CoA ligase, using acetyl-CoA as substrate. In Bacillus subtilis, this is Lys609, but it may correspond to another position in orthologs. This acetylation results in inhibition of acetyl-CoA synthetase.”
- database_cross_reference “PMID:15236963”
- database_cross_reference “PMID:40089509”
- database_cross_reference “PMID:39019872”
acetyl-CoA synthetase acetyltransferase activity SubClassOf protein-lysine-acetyltransferase activity
acetyl-CoA synthetase acetyltransferase activity SubClassOf ligase inhibitor activity
acetyl-CoA synthetase acetyltransferase activity SubClassOf negatively regulates some acetyl-CoA synthetase activity

acetyl-CoA synthetase activity `http://purl.obolibrary.org/obo/GO_0003987`

Removed

acetyl-CoA synthetase activity label “acetate-CoA ligase activity”
acetyl-CoA synthetase activity definition “Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.”
- database_cross_reference “EC:6.2.1.1”
acetyl-CoA synthetase activity has_related_synonym “acetyl-CoA synthetase activity”
- database_cross_reference “EC:6.2.1.1”
acetyl-CoA synthetase activity SubClassOf acid-thiol ligase activity

Added

acetyl-CoA synthetase activity has_exact_synonym “acetyl-coenzyme A synthetase activity”
acetyl-CoA synthetase activity definition “Catalysis of the reaction: acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate.”
- database_cross_reference “RHEA:23176”
acetyl-CoA synthetase activity label “acetyl-CoA synthetase activity”
acetyl-CoA synthetase activity has_exact_synonym “acetate-CoA ligase activity”

acetylalkylglycerol acetylhydrolase activity `http://purl.obolibrary.org/obo/GO_0047378`

Added

acetylesterase activity `http://purl.obolibrary.org/obo/GO_0008126`

Added

acetylesterase activity narrowMatch 58148
acetylesterase activity database_cross_reference “RHEA:58148”

acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity `http://purl.obolibrary.org/obo/GO_0047224`

Added

acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity database_cross_reference “Reactome:R-HSA-914010”
- label “B3GNT6 transfers GlcNAc to Tn antigen”

acetylglucosaminyltransferase activity `http://purl.obolibrary.org/obo/GO_0008375`

Removed

acetylglucosaminyltransferase activity database_cross_reference “Reactome:R-HSA-8879117”
- label “POMGNT2 transfers GlcNAc to Man-DAG1”

Added

acetylglucosaminyltransferase activity database_cross_reference “Reactome:R-HSA-5617037”
- label “POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1”

acid-CoA ligase (GDP-forming) activity `http://purl.obolibrary.org/obo/GO_0047612`

Removed

acid-CoA ligase (GDP-forming) activity SubClassOf acid-thiol ligase activity

Added

acid-CoA ligase (GDP-forming) activity SubClassOf CoA-ligase activity

acid-ammonia (or amide) ligase activity `http://purl.obolibrary.org/obo/GO_0016880`

Removed

acid-ammonia (or amide) ligase activity definition “Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:jl”

Added

acid-ammonia (or amide) ligase activity definition “Catalysis of the ligation of an acid to ammonia (NH4+) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:jl”

acrosomal lumen `http://purl.obolibrary.org/obo/GO_0043160`

Removed

acrosomal lumen definition “The volume enclosed within the acrosome membrane.”
- database_cross_reference “GOC:go_curators”

Added

acrosomal lumen definition “The volume enclosed within the acrosome membrane.”
- database_cross_reference “GOC:curators”

action potential `http://purl.obolibrary.org/obo/GO_0001508`

Removed

action potential definition “A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”
- database_cross_reference “ISBN:978-0-07-139011-8”

Added

action potential definition “A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”
- database_cross_reference “ISBN:978-0-07-139011-8”

activin A complex `http://purl.obolibrary.org/obo/GO_0043509`

Removed

activin A complex definition “A nonsteroidal regulator, composed of two covalently linked inhibin beta-A subunits (sometimes known as activin beta-A or activin/inhibin beta-A).”
- database_cross_reference “GOC:go_curators”

Added

activin A complex definition “A nonsteroidal regulator, composed of two covalently linked inhibin beta-A subunits (sometimes known as activin beta-A or activin/inhibin beta-A).”
- database_cross_reference “GOC:curators”

activin AB complex `http://purl.obolibrary.org/obo/GO_0048183`

Removed

activin AB complex definition “A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits (sometimes known as activin beta or activin/inhibin beta), inhibin beta-A and inhibin beta-B.”
- database_cross_reference “GOC:go_curators”

Added

activin AB complex definition “A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits (sometimes known as activin beta or activin/inhibin beta), inhibin beta-A and inhibin beta-B.”
- database_cross_reference “GOC:curators”

activin B complex `http://purl.obolibrary.org/obo/GO_0043510`

Removed

activin B complex definition “A nonsteroidal regulator, composed of two covalently linked inhibin beta-B subunits (sometimes known as activin beta-B or activin/inhibin beta-B).”
- database_cross_reference “GOC:go_curators”

Added

activin B complex definition “A nonsteroidal regulator, composed of two covalently linked inhibin beta-B subunits (sometimes known as activin beta-B or activin/inhibin beta-B).”
- database_cross_reference “GOC:curators”

activin complex `http://purl.obolibrary.org/obo/GO_0048180`

Removed

activin complex definition “A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits, inhibin beta-A and inhibin beta-B (sometimes known as activin beta or activin/inhibin beta). There are three forms of activin complex, activin A, which is composed of 2 inhibin beta-A subunits, activin B, which is composed of 2 inhibin beta-B subunits, and activin AB, which is composed of an inhibin beta-A and an inhibin beta-B subunit.”
- database_cross_reference “GOC:go_curators”
activin complex SubClassOf part of some obsolete extracellular space
activin complex SubClassOf protein-containing complex

Added

activin complex definition “A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits, inhibin beta-A and inhibin beta-B (sometimes known as activin beta or activin/inhibin beta). There are three forms of activin complex, activin A, which is composed of 2 inhibin beta-A subunits, activin B, which is composed of 2 inhibin beta-B subunits, and activin AB, which is composed of an inhibin beta-A and an inhibin beta-B subunit.”
- database_cross_reference “GOC:curators”
activin complex SubClassOf extracellular protein-containing complex

actomyosin `http://purl.obolibrary.org/obo/GO_0042641`

Removed

actomyosin definition “Any complex of actin, myosin, and accessory proteins.”
- database_cross_reference “GOC:go_curators”

Added

actomyosin definition “Any complex of actin, myosin, and accessory proteins.”
- database_cross_reference “GOC:curators”

actomyosin, myosin complex part `http://purl.obolibrary.org/obo/GO_0042642`

Removed

actomyosin, myosin complex part definition “The myosin part of any complex of actin, myosin, and accessory proteins.”
- database_cross_reference “GOC:go_curators”

Added

actomyosin, myosin complex part definition “The myosin part of any complex of actin, myosin, and accessory proteins.”
- database_cross_reference “GOC:curators”

acyl-CoA hydrolase activity `http://purl.obolibrary.org/obo/GO_0016289`

Added

acyl-CoA hydrolase activity database_cross_reference “RHEA:70419”
acyl-CoA hydrolase activity narrowMatch 70411
acyl-CoA hydrolase activity database_cross_reference “RHEA:70331”
acyl-CoA hydrolase activity database_cross_reference “RHEA:49444”
acyl-CoA hydrolase activity narrowMatch 40219
acyl-CoA hydrolase activity database_cross_reference “RHEA:70411”
acyl-CoA hydrolase activity database_cross_reference “RHEA:45716”
acyl-CoA hydrolase activity narrowMatch 70419
acyl-CoA hydrolase activity database_cross_reference “RHEA:59936”
acyl-CoA hydrolase activity database_cross_reference “RHEA:31511”
acyl-CoA hydrolase activity narrowMatch 70427
acyl-CoA hydrolase activity database_cross_reference “RHEA:70427”
acyl-CoA hydrolase activity narrowMatch 66704
acyl-CoA hydrolase activity narrowMatch 49444
acyl-CoA hydrolase activity narrowMatch 46224
acyl-CoA hydrolase activity database_cross_reference “RHEA:28542”
acyl-CoA hydrolase activity narrowMatch 70331
acyl-CoA hydrolase activity database_cross_reference “RHEA:19741”
acyl-CoA hydrolase activity narrowMatch 70415
acyl-CoA hydrolase activity database_cross_reference “RHEA:46224”
acyl-CoA hydrolase activity narrowMatch 28542
acyl-CoA hydrolase activity narrowMatch 19741
acyl-CoA hydrolase activity narrowMatch 45716
acyl-CoA hydrolase activity narrowMatch 31511
acyl-CoA hydrolase activity narrowMatch 59936
acyl-CoA hydrolase activity database_cross_reference “RHEA:70415”
acyl-CoA hydrolase activity database_cross_reference “RHEA:40219”
acyl-CoA hydrolase activity database_cross_reference “RHEA:78267”
acyl-CoA hydrolase activity narrowMatch 78267
acyl-CoA hydrolase activity database_cross_reference “RHEA:66704”

acyl-CoA oxidase activity `http://purl.obolibrary.org/obo/GO_0003997`

Added

acyl-CoA oxidase activity database_cross_reference “RHEA:67212”
acyl-CoA oxidase activity database_cross_reference “RHEA:66216”
acyl-CoA oxidase activity database_cross_reference “RHEA:39071”
acyl-CoA oxidase activity narrowMatch 66224
acyl-CoA oxidase activity database_cross_reference “RHEA:66220”
acyl-CoA oxidase activity narrowMatch 66208
acyl-CoA oxidase activity database_cross_reference “RHEA:66224”
acyl-CoA oxidase activity database_cross_reference “RHEA:40315”
acyl-CoA oxidase activity narrowMatch 22952
acyl-CoA oxidase activity narrowMatch 39087
acyl-CoA oxidase activity narrowMatch 66232
acyl-CoA oxidase activity database_cross_reference “RHEA:40471”
acyl-CoA oxidase activity narrowMatch 66236
acyl-CoA oxidase activity narrowMatch 66216
acyl-CoA oxidase activity narrowMatch 66212
acyl-CoA oxidase activity database_cross_reference “RHEA:22952”
acyl-CoA oxidase activity database_cross_reference “RHEA:66212”
acyl-CoA oxidase activity narrowMatch 40275
acyl-CoA oxidase activity database_cross_reference “RHEA:66236”
acyl-CoA oxidase activity narrowMatch 40271
acyl-CoA oxidase activity database_cross_reference “RHEA:40271”
acyl-CoA oxidase activity database_cross_reference “RHEA:39087”
acyl-CoA oxidase activity database_cross_reference “RHEA:66232”
acyl-CoA oxidase activity narrowMatch 66228
acyl-CoA oxidase activity narrowMatch 40471
acyl-CoA oxidase activity narrowMatch 39071
acyl-CoA oxidase activity narrowMatch 40315
acyl-CoA oxidase activity database_cross_reference “RHEA:66208”
acyl-CoA oxidase activity narrowMatch 66220
acyl-CoA oxidase activity database_cross_reference “RHEA:40275”
acyl-CoA oxidase activity database_cross_reference “RHEA:66228”
acyl-CoA oxidase activity narrowMatch 67212

acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0008780`

Added

acyl-lipid omega-3 desaturase (cytochrome b5) activity `http://purl.obolibrary.org/obo/GO_0102859`

Added

acyl-lipid omega-6 desaturase (cytochrome b5) activity `http://purl.obolibrary.org/obo/GO_0050184`

Added

acylglycerol kinase activity `http://purl.obolibrary.org/obo/GO_0047620`

Added

acylglycerol kinase activity database_cross_reference “RHEA:33747”
acylglycerol kinase activity narrowMatch 33747
acylglycerol kinase activity narrowMatch 39847
acylglycerol kinase activity database_cross_reference “RHEA:39847”

acyltransferase activity, acyl groups converted into alkyl on transfer `http://purl.obolibrary.org/obo/GO_0046912`

Removed

acyltransferase activity, acyl groups converted into alkyl on transfer definition “Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer.”
- database_cross_reference “GOC:jl”

Added

acyltransferase activity, acyl groups converted into alkyl on transfer definition “Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer.”
- database_cross_reference “GOC:jl”
- database_cross_reference “EC:2.3.3.-“

adenine biosynthetic process `http://purl.obolibrary.org/obo/GO_0046084`

Removed

adenine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine.”
- database_cross_reference “GOC:go_curators”

Added

adenine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine.”
- database_cross_reference “GOC:curators”

adenine metabolic process `http://purl.obolibrary.org/obo/GO_0046083`

Removed

adenine metabolic process definition “The chemical reactions and pathways involving adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine.”
- database_cross_reference “GOC:go_curators”

Added

adenine metabolic process definition “The chemical reactions and pathways involving adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine.”
- database_cross_reference “GOC:curators”

adenine salvage `http://purl.obolibrary.org/obo/GO_0006168`

Added

adenine salvage broadMatch PWY-6605
adenine salvage exactMatch PWY-6610
adenine salvage broadMatch PWY-6609
adenine salvage broadMatch PWY-6611
adenine salvage term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
adenine salvage broadMatch P121-PWY
adenine salvage database_cross_reference “MetaCyc:PWY-6610”
adenine salvage broadMatch PWY-6619

adenine transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015207`

Removed

adenine transmembrane transporter activity definition “Enables the transfer of adenine, 6-aminopurine, from one side of a membrane to the other.”
- database_cross_reference “GOC:go_curators”

Added

adenine transmembrane transporter activity definition “Enables the transfer of adenine, 6-aminopurine, from one side of a membrane to the other.”
- database_cross_reference “GOC:curators”

adenine transport `http://purl.obolibrary.org/obo/GO_0015853`

Removed

adenine transport definition “The directed movement of adenine, 6-aminopurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

adenine transport definition “The directed movement of adenine, 6-aminopurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

adenosine biosynthetic process `http://purl.obolibrary.org/obo/GO_0046086`

Removed

adenosine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes.”
- database_cross_reference “GOC:go_curators”

Added

adenosine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes.”
- database_cross_reference “GOC:curators”

adenosine catabolic process `http://purl.obolibrary.org/obo/GO_0006154`

Removed

adenosine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes.”
- database_cross_reference “GOC:go_curators”

Added

adenosine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes.”
- database_cross_reference “GOC:curators”

adenosine deaminase activity `http://purl.obolibrary.org/obo/GO_0004000`

Removed

adenosine deaminase activity definition “Catalysis of the reaction: adenosine + H2O = inosine + NH3.”
- database_cross_reference “RHEA:24408”

Added

adenosine deaminase activity definition “Catalysis of the reaction: adenosine + H2O = inosine + NH4+.”
- database_cross_reference “RHEA:24408”

adenosine metabolic process `http://purl.obolibrary.org/obo/GO_0046085`

Removed

adenosine metabolic process definition “The chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes.”
- database_cross_reference “GOC:go_curators”

Added

adenosine metabolic process definition “The chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes.”
- database_cross_reference “GOC:curators”

adenosine salvage `http://purl.obolibrary.org/obo/GO_0006169`

Added

adenosine salvage broadMatch PWY-6609
adenosine salvage broadMatch PWY-6605
adenosine salvage broadMatch PWY-6619
adenosine salvage broadMatch P121-PWY
adenosine salvage broadMatch PWY-6611
adenosine salvage term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI

adenosine-phosphate deaminase activity `http://purl.obolibrary.org/obo/GO_0047623`

Removed

adenosine-phosphate deaminase activity definition “Catalysis of the reaction: an adenosine-phosphate + H20 = an inosine phosphate + NH3. Catalyzes the deamination of AMP, ADP or ATP.”
- database_cross_reference “EC:3.5.4.17”

Added

adenosine-phosphate deaminase activity definition “Catalysis of the reaction: an adenosine-phosphate + H20 = an inosine phosphate + NH4+. Catalyzes the deamination of AMP, ADP or ATP.”
- database_cross_reference “EC:3.5.4.17”

adenylyltransferase activity `http://purl.obolibrary.org/obo/GO_0070566`

Added

adenylyltransferase activity database_cross_reference “Reactome:R-HSA-9935837”
- label “The TRAMP:RNA exosome oligoadenylates pre-rRNA 5’ external transcribed spacer (5’ETS) fragment”

adhesion of symbiont to host `http://purl.obolibrary.org/obo/GO_0044406`

Added

adhesion of symbiont to host database_cross_reference “Reactome:R-HSA-9638630”
- label “Attachment of bacteria to epithelial cells”

adult salivary gland morphogenesis `http://purl.obolibrary.org/obo/GO_0007437`

Removed

adult salivary gland morphogenesis definition “The process in which the anatomical structures of the adult salivary gland are generated and organized.”
- database_cross_reference “GOC:go_curators”

Added

adult salivary gland morphogenesis definition “The process in which the anatomical structures of the adult salivary gland are generated and organized.”
- database_cross_reference “GOC:curators”

aerobic ammonia oxidation to nitrite via pyruvic oxime `http://purl.obolibrary.org/obo/GO_0070275`

Removed

aerobic ammonia oxidation to nitrite via pyruvic oxime definition “The metabolic process in which ammonia (NH3) is oxidized to nitrite (NO2) in the presence of oxygen. Hydroxylamine is produced enzymatically, and, in the presence of pyruvate, forms pyruvic oxime in a spontaneous, non-enzymatic reaction; pyruvic oxime is then converted to nitrite.”
- database_cross_reference “MetaCyc:PWY-2242”

Added

aerobic ammonia oxidation to nitrite via pyruvic oxime definition “The metabolic process in which ammonia (NH4+) is oxidized to nitrite (NO2) in the presence of oxygen. Hydroxylamine is produced enzymatically, and, in the presence of pyruvate, forms pyruvic oxime in a spontaneous, non-enzymatic reaction; pyruvic oxime is then converted to nitrite.”
- database_cross_reference “MetaCyc:PWY-2242”

aerobic cobalamin biosynthetic process `http://purl.obolibrary.org/obo/GO_0019250`

Removed

aerobic cobalamin biosynthetic process definition “The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the presence of oxygen.”
- database_cross_reference “GOC:go_curators”

Added

aerobic cobalamin biosynthetic process definition “The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the presence of oxygen.”
- database_cross_reference “GOC:curators”

aerobic electron transport chain `http://purl.obolibrary.org/obo/GO_0019646`

Added

aerobic electron transport chain term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
aerobic electron transport chain database_cross_reference “MetaCyc:PWY-3781”

aerobic respiration `http://purl.obolibrary.org/obo/GO_0009060`

Removed

aerobic respiration database_cross_reference “MetaCyc:PWY-3781”

aerobic respiration, using ammonia as electron donor `http://purl.obolibrary.org/obo/GO_0019409`

Removed

aerobic respiration, using ammonia as electron donor definition “The metabolic process in which ammonia (NH3) is oxidized to nitrite (NO2) in the presence of oxygen; enzymatic reactions convert ammonia to hydrazine, and hydrazine to nitrite.”
- database_cross_reference “MetaCyc:AMMOXID-PWY”

Added

aerobic respiration, using ammonia as electron donor definition “The metabolic process in which ammonia (NH4+) is oxidized to nitrite (NO2) in the presence of oxygen; enzymatic reactions convert ammonia to hydrazine, and hydrazine to nitrite.”
- database_cross_reference “MetaCyc:AMMOXID-PWY”

agmatine deiminase activity `http://purl.obolibrary.org/obo/GO_0047632`

Removed

agmatine deiminase activity definition “Catalysis of the reaction: agmatine + H2O = N-carbamoylputrescine + NH3.”
- database_cross_reference “MetaCyc:AGMATINE-DEIMINASE-RXN”
- database_cross_reference “EC:3.5.3.12”

Added

agmatine deiminase activity definition “Catalysis of the reaction: agmatine + H2O = N-carbamoylputrescine + NH4+.”
- database_cross_reference “RHEA:18037”

alanine biosynthetic process `http://purl.obolibrary.org/obo/GO_0006523`

Removed

alanine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of alanine, 2-aminopropanoic acid.”
- database_cross_reference “GOC:go_curators”
alanine biosynthetic process SubClassOf obsolete alanine metabolic process

Added

alanine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of alanine, 2-aminopropanoic acid.”
- database_cross_reference “GOC:curators”

alcohol O-acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0004026`

Added

alcohol O-acetyltransferase activity narrowMatch 65456
alcohol O-acetyltransferase activity narrowMatch 65460
alcohol O-acetyltransferase activity narrowMatch 55972
alcohol O-acetyltransferase activity database_cross_reference “RHEA:64624”
alcohol O-acetyltransferase activity narrowMatch 65468
alcohol O-acetyltransferase activity narrowMatch 64632
alcohol O-acetyltransferase activity database_cross_reference “RHEA:64676”
alcohol O-acetyltransferase activity narrowMatch 64624
alcohol O-acetyltransferase activity narrowMatch 65236
alcohol O-acetyltransferase activity narrowMatch 64676
alcohol O-acetyltransferase activity narrowMatch 64628
alcohol O-acetyltransferase activity database_cross_reference “RHEA:55972”
alcohol O-acetyltransferase activity database_cross_reference “RHEA:65468”
alcohol O-acetyltransferase activity database_cross_reference “RHEA:65456”
alcohol O-acetyltransferase activity database_cross_reference “RHEA:65460”
alcohol O-acetyltransferase activity database_cross_reference “RHEA:64628”
alcohol O-acetyltransferase activity database_cross_reference “RHEA:64632”
alcohol O-acetyltransferase activity database_cross_reference “RHEA:65236”

alcohol biosynthetic process `http://purl.obolibrary.org/obo/GO_0046165`

Added

alcohol biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31485”^^anyURI
alcohol biosynthetic process in_subset gocheck_do_not_annotate

alcohol catabolic process `http://purl.obolibrary.org/obo/GO_0046164`

Added

alcohol catabolic process in_subset gocheck_do_not_annotate
alcohol catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31485”^^anyURI

alcohol dehydrogenase (NADP+) activity `http://purl.obolibrary.org/obo/GO_0008106`

Added

alcohol dehydrogenase (NADP+) activity database_cross_reference “Reactome:R-HSA-192160”
- label “5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol”
alcohol dehydrogenase (NADP+) activity database_cross_reference “Reactome:R-HSA-9027598”
- label “Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3”
alcohol dehydrogenase (NADP+) activity database_cross_reference “Reactome:R-HSA-9027562”
- label “Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA”
alcohol dehydrogenase (NADP+) activity database_cross_reference “Reactome:R-HSA-193781”
- label “5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol”
alcohol dehydrogenase (NADP+) activity database_cross_reference “Reactome:R-HSA-9937340”
- label “DHRSX reduces dolichal to dolichol”
alcohol dehydrogenase (NADP+) activity database_cross_reference “Reactome:R-HSA-193800”
- label “5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol”
alcohol dehydrogenase (NADP+) activity database_cross_reference “Reactome:R-HSA-192036”
- label “5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol”
alcohol dehydrogenase (NADP+) activity database_cross_reference “Reactome:R-HSA-192067”
- label “4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one”
alcohol dehydrogenase (NADP+) activity database_cross_reference “Reactome:R-HSA-2855252”
- label “AKRs reduce RBP2:atRAL to RBP2:atROL”
alcohol dehydrogenase (NADP+) activity database_cross_reference “Reactome:R-HSA-198845”
- label “CYB5A:heme reduces Asc.- to AscH-“
alcohol dehydrogenase (NADP+) activity database_cross_reference “Reactome:R-HSA-193746”
- label “4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one”
alcohol dehydrogenase (NADP+) activity database_cross_reference “Reactome:R-HSA-193824”
- label “4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one”
alcohol dehydrogenase (NADP+) activity database_cross_reference “Reactome:R-HSA-193841”
- label “5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol”
alcohol dehydrogenase (NADP+) activity database_cross_reference “Reactome:R-HSA-192033”
- label “4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one”
alcohol dehydrogenase (NADP+) activity database_cross_reference “Reactome:R-HSA-193758”
- label “5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol”
alcohol dehydrogenase (NADP+) activity database_cross_reference “Reactome:R-HSA-193821”
- label “4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one”
alcohol dehydrogenase (NADP+) activity database_cross_reference “Reactome:R-HSA-193755”
- label “4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one”
alcohol dehydrogenase (NADP+) activity database_cross_reference “Reactome:R-HSA-9027600”
- label “Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3”
alcohol dehydrogenase (NADP+) activity database_cross_reference “Reactome:R-HSA-5423637”
- label “AKR dimers reduce AFBDHO to AFBDOH”
alcohol dehydrogenase (NADP+) activity database_cross_reference “Reactome:R-HSA-5692232”
- label “AKR1A1 oxidises BaPtDHD to BaP-7,8-dione”
alcohol dehydrogenase (NADP+) activity database_cross_reference “Reactome:R-HSA-9027531”
- label “Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA”

alcohol dehydrogenase (cytochrome c(L)) activity `http://purl.obolibrary.org/obo/GO_0052933`

Added

alcohol dehydrogenase (cytochrome c) activity `http://purl.obolibrary.org/obo/GO_0052934`

Added

alcohol dehydrogenase (cytochrome c) activity database_cross_reference “RHEA:79319”
alcohol dehydrogenase (cytochrome c) activity database_cross_reference “RHEA:55944”
alcohol dehydrogenase (cytochrome c) activity narrowMatch 43432
alcohol dehydrogenase (cytochrome c) activity narrowMatch 55944
alcohol dehydrogenase (cytochrome c) activity database_cross_reference “RHEA:79331”
alcohol dehydrogenase (cytochrome c) activity database_cross_reference “RHEA:43432”
alcohol dehydrogenase (cytochrome c) activity database_cross_reference “RHEA:79359”
alcohol dehydrogenase (cytochrome c) activity narrowMatch 79319
alcohol dehydrogenase (cytochrome c) activity database_cross_reference “RHEA:62204”
alcohol dehydrogenase (cytochrome c) activity database_cross_reference “RHEA:62200”
alcohol dehydrogenase (cytochrome c) activity narrowMatch 62204
alcohol dehydrogenase (cytochrome c) activity narrowMatch 79323
alcohol dehydrogenase (cytochrome c) activity narrowMatch 79359
alcohol dehydrogenase (cytochrome c) activity narrowMatch 62200
alcohol dehydrogenase (cytochrome c) activity database_cross_reference “RHEA:79323”
alcohol dehydrogenase (cytochrome c) activity narrowMatch 79331
alcohol dehydrogenase (cytochrome c) activity database_cross_reference “RHEA:79335”
alcohol dehydrogenase (cytochrome c) activity narrowMatch 79335

alcohol metabolic process `http://purl.obolibrary.org/obo/GO_0006066`

Added

alcohol metabolic process in_subset gocheck_do_not_annotate
alcohol metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31485”^^anyURI

alcohol oxidase activity `http://purl.obolibrary.org/obo/GO_0047639`

Added

alcohol oxidase activity database_cross_reference “RHEA:69496”
alcohol oxidase activity database_cross_reference “RHEA:25311”
alcohol oxidase activity narrowMatch 69492
alcohol oxidase activity narrowMatch 43504
alcohol oxidase activity database_cross_reference “RHEA:69492”
alcohol oxidase activity database_cross_reference “RHEA:31679”
alcohol oxidase activity narrowMatch 69496
alcohol oxidase activity narrowMatch 31679
alcohol oxidase activity narrowMatch 25311
alcohol oxidase activity database_cross_reference “RHEA:43504”

alcohol sulfotransferase activity `http://purl.obolibrary.org/obo/GO_0004027`

Added

alcohol sulfotransferase activity database_cross_reference “RHEA:59300”
alcohol sulfotransferase activity database_cross_reference “RHEA:59304”
alcohol sulfotransferase activity narrowMatch 59300
alcohol sulfotransferase activity narrowMatch 59304

alcohol transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015665`

Added

alcohol transmembrane transporter activity database_cross_reference “Reactome:R-HSA-193808”
- label “5beta-cholestan-3alpha,7alpha,27-triol is translocated from the cytosol to the mitochondrial matrix”
alcohol transmembrane transporter activity database_cross_reference “Reactome:R-HSA-193715”
- label “5beta-cholestan-3alpha,7alpha,24(S)-triol is translocated from the cytosol to the mitochondrial matrix”
alcohol transmembrane transporter activity database_cross_reference “Reactome:R-HSA-193537”
- label “5beta-cholestan-3alpha, 7alpha-diol is translocated from the cytosol to the mitochondrial matrix”
alcohol transmembrane transporter activity database_cross_reference “Reactome:R-HSA-193832”
- label “5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is translocated from the cytosol to the mitochondrial matrix”
alcohol transmembrane transporter activity database_cross_reference “Reactome:R-HSA-193774”
- label “5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is translocated from the cytosol to the mitochondrial matrix”
alcohol transmembrane transporter activity database_cross_reference “Reactome:R-HSA-192010”
- label “5beta-cholestan-3alpha, 7alpha, 12alpha-triol is translocated from the cytosol to the mitochondrial matrix”

alcohol-forming long-chain fatty acyl-CoA reductase activity `http://purl.obolibrary.org/obo/GO_0102965`

Added

alcohol-forming very long-chain fatty acyl-CoA reductase activity `http://purl.obolibrary.org/obo/GO_0080019`

Added

aldarate transmembrane transport `http://purl.obolibrary.org/obo/GO_0042869`

Removed

aldarate transmembrane transport definition “The process in which aldarate is transported across a lipid bilayer, from one side of a membrane to the other.”
- database_cross_reference “GOC:go_curators”

Added

aldarate transmembrane transport definition “The process in which aldarate is transported across a lipid bilayer, from one side of a membrane to the other.”
- database_cross_reference “GOC:curators”

aldarate transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0042876`

Removed

aldarate transmembrane transporter activity definition “Enables the transfer of aldarate from one side of a membrane to the other.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:15034926”

Added

aldarate transmembrane transporter activity definition “Enables the transfer of aldarate from one side of a membrane to the other.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:15034926”

aldehyde dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0004029`

Added

aldehyde dehydrogenase (NAD+) activity narrowMatch 47932
aldehyde dehydrogenase (NAD+) activity narrowMatch 76667
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:31243”
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:33803”
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:31043”
aldehyde dehydrogenase (NAD+) activity narrowMatch 47152
aldehyde dehydrogenase (NAD+) activity narrowMatch 42340
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:39039”
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:31299”
aldehyde dehydrogenase (NAD+) activity narrowMatch 67252
aldehyde dehydrogenase (NAD+) activity narrowMatch 61632
aldehyde dehydrogenase (NAD+) activity narrowMatch 31059
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:61632”
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:60688”
aldehyde dehydrogenase (NAD+) activity narrowMatch 69084
aldehyde dehydrogenase (NAD+) activity narrowMatch 30867
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:45764”
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:42340”
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:30879”
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:69088”
aldehyde dehydrogenase (NAD+) activity narrowMatch 76655
aldehyde dehydrogenase (NAD+) activity narrowMatch 60688
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:81191”
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:60708”
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:67252”
aldehyde dehydrogenase (NAD+) activity narrowMatch 75119
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:81419”
aldehyde dehydrogenase (NAD+) activity narrowMatch 31299
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:30867”
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:69168”
aldehyde dehydrogenase (NAD+) activity narrowMatch 30879
aldehyde dehydrogenase (NAD+) activity narrowMatch 81419
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:69084”
aldehyde dehydrogenase (NAD+) activity narrowMatch 67256
aldehyde dehydrogenase (NAD+) activity narrowMatch 31515
aldehyde dehydrogenase (NAD+) activity narrowMatch 60708
aldehyde dehydrogenase (NAD+) activity narrowMatch 34219
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:67256”
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:47932”
aldehyde dehydrogenase (NAD+) activity narrowMatch 45764
aldehyde dehydrogenase (NAD+) activity narrowMatch 31043
aldehyde dehydrogenase (NAD+) activity narrowMatch 59432
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:31215”
aldehyde dehydrogenase (NAD+) activity narrowMatch 42384
aldehyde dehydrogenase (NAD+) activity narrowMatch 69168
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:47152”
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:34219”
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:76667”
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:31259”
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:69164”
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:31231”
aldehyde dehydrogenase (NAD+) activity narrowMatch 39039
aldehyde dehydrogenase (NAD+) activity narrowMatch 31215
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:42384”
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:75119”
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:31515”
aldehyde dehydrogenase (NAD+) activity narrowMatch 69080
aldehyde dehydrogenase (NAD+) activity narrowMatch 69088
aldehyde dehydrogenase (NAD+) activity narrowMatch 69164
aldehyde dehydrogenase (NAD+) activity narrowMatch 81191
aldehyde dehydrogenase (NAD+) activity narrowMatch 31259
aldehyde dehydrogenase (NAD+) activity narrowMatch 33803
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:69080”
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:31059”
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:76655”
aldehyde dehydrogenase (NAD+) activity narrowMatch 31231
aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:59432”
aldehyde dehydrogenase (NAD+) activity narrowMatch 31243

aldehyde dehydrogenase (NADP+) activity `http://purl.obolibrary.org/obo/GO_0033721`

Added

aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:62248”
aldehyde dehydrogenase (NADP+) activity narrowMatch 72539
aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:34215”
aldehyde dehydrogenase (NADP+) activity narrowMatch 80823
aldehyde dehydrogenase (NADP+) activity narrowMatch 28410
aldehyde dehydrogenase (NADP+) activity narrowMatch 60684
aldehyde dehydrogenase (NADP+) activity narrowMatch 60728
aldehyde dehydrogenase (NADP+) activity narrowMatch 47928
aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:28410”
aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:60736”
aldehyde dehydrogenase (NADP+) activity narrowMatch 81423
aldehyde dehydrogenase (NADP+) activity narrowMatch 30803
aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:60740”
aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:81423”
aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:72539”
aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:80823”
aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:76671”
aldehyde dehydrogenase (NADP+) activity narrowMatch 68412
aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:60680”
aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:60732”
aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:60716”
aldehyde dehydrogenase (NADP+) activity narrowMatch 60716
aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:60728”
aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:72535”
aldehyde dehydrogenase (NADP+) activity narrowMatch 72535
aldehyde dehydrogenase (NADP+) activity narrowMatch 60736
aldehyde dehydrogenase (NADP+) activity narrowMatch 60732
aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:68412”
aldehyde dehydrogenase (NADP+) activity narrowMatch 76671
aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:60684”
aldehyde dehydrogenase (NADP+) activity narrowMatch 60740
aldehyde dehydrogenase (NADP+) activity narrowMatch 60680
aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:30803”
aldehyde dehydrogenase (NADP+) activity narrowMatch 34215
aldehyde dehydrogenase (NADP+) activity narrowMatch 62248
aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:47928”

aldehyde metabolic process `http://purl.obolibrary.org/obo/GO_0006081`

Removed

aldehyde metabolic process definition “The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

aldehyde metabolic process definition “The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

aldehyde oxidase activity `http://purl.obolibrary.org/obo/GO_0004031`

Removed

aldehyde oxidase activity definition “Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide.”
- database_cross_reference “EC:1.2.3.1”

Added

aldehyde oxidase activity narrowMatch 58964
aldehyde oxidase activity narrowMatch 58988
aldehyde oxidase activity database_cross_reference “RHEA:56736”
aldehyde oxidase activity database_cross_reference “RHEA:33439”
aldehyde oxidase activity definition “Catalysis of the reaction: an aldehyde + O2 + H2O = a carboxylate + H2O2 + H+.”
- database_cross_reference “RHEA:16829”
aldehyde oxidase activity database_cross_reference “RHEA:59004”
aldehyde oxidase activity database_cross_reference “RHEA:58984”
aldehyde oxidase activity database_cross_reference “RHEA:58964”
aldehyde oxidase activity narrowMatch 58980
aldehyde oxidase activity narrowMatch 33439
aldehyde oxidase activity narrowMatch 59004
aldehyde oxidase activity database_cross_reference “RHEA:58988”
aldehyde oxidase activity database_cross_reference “RHEA:49636”
aldehyde oxidase activity database_cross_reference “RHEA:58976”
aldehyde oxidase activity narrowMatch 58976
aldehyde oxidase activity database_cross_reference “RHEA:58980”
aldehyde oxidase activity database_cross_reference “RHEA:59000”
aldehyde oxidase activity narrowMatch 58984
aldehyde oxidase activity narrowMatch 59000
aldehyde oxidase activity narrowMatch 56736
aldehyde oxidase activity narrowMatch 49636

aldose 1-dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0047640`

Added

aldose 1-dehydrogenase activity narrowMatch 42392
aldose 1-dehydrogenase activity narrowMatch 62076
aldose 1-dehydrogenase activity database_cross_reference “RHEA:42392”
aldose 1-dehydrogenase activity database_cross_reference “RHEA:62076”

aldose 1-epimerase activity `http://purl.obolibrary.org/obo/GO_0004034`

Added

aldose 1-epimerase activity database_cross_reference “Reactome:R-HSA-9931926”
- label “Defective GALM doesn’t convert beta-D-GAL to alpha-D-GAL”
aldose 1-epimerase activity database_cross_reference “Reactome:R-HSA-9931853”
- label “GALM converts beta-D-GAL to alpha-D-GAL”

aldose reductase (NADPH) activity `http://purl.obolibrary.org/obo/GO_0004032`

Added

aldose reductase (NADPH) activity database_cross_reference “RHEA:59924”
aldose reductase (NADPH) activity narrowMatch 59924
aldose reductase (NADPH) activity database_cross_reference “Reactome:R-HSA-9931850”
- label “AKR1B1 reduces galactose to galactitol”

aliphatic amine dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0030058`

Added

aliphatic amine dehydrogenase activity narrowMatch 21916
aliphatic amine dehydrogenase activity database_cross_reference “RHEA:21916”

aliphatic amine oxidase activity `http://purl.obolibrary.org/obo/GO_0052595`

Removed

aliphatic amine oxidase activity definition “Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+.”
- database_cross_reference “MetaCyc:AMINEOXID-RXN”

Added

aliphatic amine oxidase activity definition “Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH4+ + H2O2 + H+.”
- database_cross_reference “MetaCyc:AMINEOXID-RXN”

aliphatic nitrilase activity `http://purl.obolibrary.org/obo/GO_0018762`

Removed

aliphatic nitrilase activity definition “Catalysis of the reaction: R-CN + H2O = R-COOH + NH3.”
- database_cross_reference “EC:3.5.5.7”

Added

aliphatic nitrilase activity definition “Catalysis of the reaction: an aliphatic nitrile + 2 H2O = a carboxylate + NH4+.”
- database_cross_reference “RHEA:46188”

alkan-1-ol dehydrogenase (acceptor) activity `http://purl.obolibrary.org/obo/GO_0047645`

Added

alkan-1-ol dehydrogenase (acceptor) activity database_cross_reference “RHEA:33571”
alkan-1-ol dehydrogenase (acceptor) activity narrowMatch 48076
alkan-1-ol dehydrogenase (acceptor) activity database_cross_reference “RHEA:76463”
alkan-1-ol dehydrogenase (acceptor) activity narrowMatch 33571
alkan-1-ol dehydrogenase (acceptor) activity database_cross_reference “RHEA:33567”
alkan-1-ol dehydrogenase (acceptor) activity narrowMatch 17085
alkan-1-ol dehydrogenase (acceptor) activity database_cross_reference “RHEA:17085”
alkan-1-ol dehydrogenase (acceptor) activity narrowMatch 51148
alkan-1-ol dehydrogenase (acceptor) activity database_cross_reference “RHEA:76459”
alkan-1-ol dehydrogenase (acceptor) activity narrowMatch 76463
alkan-1-ol dehydrogenase (acceptor) activity narrowMatch 76459
alkan-1-ol dehydrogenase (acceptor) activity database_cross_reference “RHEA:76451”
alkan-1-ol dehydrogenase (acceptor) activity database_cross_reference “RHEA:48076”
alkan-1-ol dehydrogenase (acceptor) activity narrowMatch 76455
alkan-1-ol dehydrogenase (acceptor) activity narrowMatch 76451
alkan-1-ol dehydrogenase (acceptor) activity database_cross_reference “RHEA:51148”
alkan-1-ol dehydrogenase (acceptor) activity narrowMatch 33567
alkan-1-ol dehydrogenase (acceptor) activity database_cross_reference “RHEA:76455”

alkanesulfonate monooxygenase activity `http://purl.obolibrary.org/obo/GO_0008726`

Added

alkanesulfonate monooxygenase activity narrowMatch 29307
alkanesulfonate monooxygenase activity database_cross_reference “RHEA:29307”
alkanesulfonate monooxygenase activity database_cross_reference “RHEA:29727”
alkanesulfonate monooxygenase activity narrowMatch 29727
alkanesulfonate monooxygenase activity database_cross_reference “RHEA:29715”
alkanesulfonate monooxygenase activity narrowMatch 29715

alkylglycerol kinase activity `http://purl.obolibrary.org/obo/GO_0047649`

Added

alkylglycerol kinase activity narrowMatch 41672
alkylglycerol kinase activity database_cross_reference “RHEA:41672”

alkylglycerone-phosphate synthase activity `http://purl.obolibrary.org/obo/GO_0008609`

Added

alkylglycerone-phosphate synthase activity database_cross_reference “RHEA:40659”
alkylglycerone-phosphate synthase activity narrowMatch 40659

all-trans-retinol binding `http://purl.obolibrary.org/obo/GO_1904768`

Added

all-trans-retinol binding database_cross_reference “Reactome:R-HSA-975633”
- label “atROL binds to RBP2”
all-trans-retinol binding database_cross_reference “Reactome:R-HSA-2404135”
- label “RBP4 binds atROL”

allantoate deiminase activity `http://purl.obolibrary.org/obo/GO_0047652`

Removed

allantoate deiminase activity definition “Catalysis of the reaction: allantoate + H2O + H+ = CO2 + NH3 + ureidoglycine.”
- database_cross_reference “MetaCyc:ALLANTOATE-DEIMINASE-RXN”
- database_cross_reference “EC:3.5.3.9”

Added

allantoate deiminase activity definition “Catalysis of the reaction: allantoate + H2O + 2 H+ = (S)-2-ureidoglycine + NH4+ + CO2.”
- database_cross_reference “RHEA:27485”

allantoin biosynthetic process `http://purl.obolibrary.org/obo/GO_0019428`

Removed

allantoin biosynthetic process definition “The chemical reactions and pathways resulting in the formation of allantoin, (2,5-dioxo-4-imidazolidinyl)urea.”
- database_cross_reference “GOC:go_curators”

Added

allantoin biosynthetic process definition “The chemical reactions and pathways resulting in the formation of allantoin, (2,5-dioxo-4-imidazolidinyl)urea.”
- database_cross_reference “GOC:curators”

alliin lyase activity `http://purl.obolibrary.org/obo/GO_0047654`

Added

alliin lyase activity database_cross_reference “RHEA:69348”
alliin lyase activity database_cross_reference “RHEA:54688”
alliin lyase activity narrowMatch 69348
alliin lyase activity narrowMatch 54688

alpha-(1->3)-fucosyltransferase activity `http://purl.obolibrary.org/obo/GO_0046920`

Removed

alpha-(1->3)-fucosyltransferase activity database_cross_reference “Reactome:R-HSA-9603984”
- label “FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX”

Added

alpha-(1->3)-fucosyltransferase activity database_cross_reference “Reactome:R-HSA-9603984”
- label “FUT4,5,9 transfer Fuc to Type 2 chains to form LeX”

alpha-1,4-N-acetylgalactosaminyltransferase activity `http://purl.obolibrary.org/obo/GO_0035248`

Removed

alpha-1,4-N-acetylgalactosaminyltransferase activity definition “Catalysis of the reaction: an N-acetyl-beta-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-beta-D-galactosaminyl derivative + UDP + H+.”
- database_cross_reference “PMID:15130086”

Added

alpha-1,4-N-acetylgalactosaminyltransferase activity database_cross_reference “RHEA:86255”
alpha-1,4-N-acetylgalactosaminyltransferase activity database_cross_reference “RHEA:86251”
alpha-1,4-N-acetylgalactosaminyltransferase activity exactMatch 86251
alpha-1,4-N-acetylgalactosaminyltransferase activity narrowMatch 86255
alpha-1,4-N-acetylgalactosaminyltransferase activity definition “Catalysis of the reaction: an N-acetyl-beta-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-beta-D-galactosaminyl derivative + UDP + H+.”
- database_cross_reference “PMID:15130086”
- database_cross_reference “RHEA:86251”

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity `http://purl.obolibrary.org/obo/GO_0030144`

Added

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity database_cross_reference “Reactome:R-HSA-8932427”
- label “MGAT5B transfers GlcNAc from UDP-GlcNAc to GlcNAc-Man-DAG1”

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity `http://purl.obolibrary.org/obo/GO_0001665`

Added

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity `http://purl.obolibrary.org/obo/GO_0003828`

Added

alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity `http://purl.obolibrary.org/obo/GO_0047290`

Added

alpha-glucuronidase activity `http://purl.obolibrary.org/obo/GO_0046559`

Added

alpha-glucuronidase activity narrowMatch 84895
alpha-glucuronidase activity database_cross_reference “RHEA:84895”
alpha-glucuronidase activity narrowMatch 84887
alpha-glucuronidase activity narrowMatch 84899
alpha-glucuronidase activity database_cross_reference “RHEA:84899”
alpha-glucuronidase activity database_cross_reference “RHEA:84891”
alpha-glucuronidase activity narrowMatch 84891
alpha-glucuronidase activity database_cross_reference “RHEA:84887”

alpha-methylacyl-CoA racemase activity `http://purl.obolibrary.org/obo/GO_0008111`

Added

alpha-methylacyl-CoA racemase activity database_cross_reference “RHEA:46724”
alpha-methylacyl-CoA racemase activity narrowMatch 46724
alpha-methylacyl-CoA racemase activity narrowMatch 63172
alpha-methylacyl-CoA racemase activity database_cross_reference “RHEA:63172”
alpha-methylacyl-CoA racemase activity narrowMatch 63176
alpha-methylacyl-CoA racemase activity database_cross_reference “RHEA:63176”

amidase activity `http://purl.obolibrary.org/obo/GO_0004040`

Added

amidase activity narrowMatch 64820
amidase activity database_cross_reference “RHEA:64820”
amidase activity narrowMatch 34375
amidase activity narrowMatch 35063
amidase activity database_cross_reference “RHEA:64824”
amidase activity database_cross_reference “RHEA:68112”
amidase activity narrowMatch 68112
amidase activity database_cross_reference “RHEA:34375”
amidase activity narrowMatch 64824
amidase activity database_cross_reference “RHEA:35063”
amidase activity narrowMatch 34367
amidase activity database_cross_reference “RHEA:34367”
amidase activity database_cross_reference “RHEA:45048”
amidase activity narrowMatch 45048

amine transport `http://purl.obolibrary.org/obo/GO_0015837`

Added

amine transport database_cross_reference “Reactome:R-HSA-549127”
- label “SLC-mediated transport of organic cations”

amino acid acyltransferase activity `http://purl.obolibrary.org/obo/GO_0140379`

Added

amino acid acyltransferase activity definition “Catalysis of the transfer of an acyl group to an acceptor group on a free amino acid, usually using acetyl-CoA as donor.”
- database_cross_reference “GOC:curators”
amino acid acyltransferase activity creation date “2026-02-02T11:14:33Z”
amino acid acyltransferase activity has_narrow_synonym “amino acid N-acetyltransferase activity”
amino acid acyltransferase activity created by “pg”
amino acid acyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31474”^^anyURI
amino acid acyltransferase activity has_obo_namespace “molecular_function”
amino acid acyltransferase activity id “GO:0140379”
amino acid acyltransferase activity label “amino acid acyltransferase activity”
Class: amino acid acyltransferase activity
amino acid acyltransferase activity SubClassOf acyltransferase activity

amino acid fermentation `http://purl.obolibrary.org/obo/GO_0019665`

Removed

amino acid fermentation definition “The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids to ammonia, CO2, H2, acetate and short chain fatty acids, under anoxic conditions.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:curators”

Added

amino acid fermentation definition “The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids to ammonia, CO2, H2, acetate and short chain fatty acids, under anoxic conditions.”
- database_cross_reference “PMID:38821505”

amino acid transaminase activity `http://purl.obolibrary.org/obo/GO_0140385`

Added

amino acid transaminase activity label “amino acid transaminase activity”
amino acid transaminase activity has_obo_namespace “molecular_function”
amino acid transaminase activity creation date “2026-02-02T13:30:09Z”
amino acid transaminase activity definition “Transfer of an amino group from an amino acid to an acceptor, usually a 2-oxo acid.”
- database_cross_reference “GOC:curators”
amino acid transaminase activity id “GO:0140385”
amino acid transaminase activity created by “pg”
amino acid transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
Class: amino acid transaminase activity
amino acid transaminase activity SubClassOf transaminase activity

amino acid transmembrane export from vacuole `http://purl.obolibrary.org/obo/GO_0032974`

Added

amino acid transmembrane export from vacuole SubClassOf intercellular transport

amino acid transmembrane import into vacuole `http://purl.obolibrary.org/obo/GO_0032975`

Added

amino acid transmembrane import into vacuole SubClassOf intercellular transport

amino acid transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015171`

Removed

amino acid transmembrane transporter activity database_cross_reference “Reactome:R-HSA-352232”
- label “SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol”
amino acid transmembrane transporter activity database_cross_reference “Reactome:R-HSA-351963”
- label “SLC6A18 transports Gly from extracellular region to cytosol”
amino acid transmembrane transporter activity database_cross_reference “Reactome:R-HSA-5659755”
- label “Defective SLC6A18 does not transport Gly from extracellular region to cytosol”

amino acid transport `http://purl.obolibrary.org/obo/GO_0006865`

Removed

amino acid transport database_cross_reference “Reactome:R-HSA-352230”
- label “Amino acid transport across the plasma membrane”

Added

amino acid transport database_cross_reference “Reactome:R-HSA-9958863”
- label “SLC-mediated transport of amino acids”

amino-acid racemase activity `http://purl.obolibrary.org/obo/GO_0047661`

Added

amino-acid racemase activity narrowMatch 59272
amino-acid racemase activity database_cross_reference “RHEA:59400”
amino-acid racemase activity database_cross_reference “RHEA:59808”
amino-acid racemase activity narrowMatch 59276
amino-acid racemase activity narrowMatch 59400
amino-acid racemase activity narrowMatch 59808
amino-acid racemase activity narrowMatch 59280
amino-acid racemase activity database_cross_reference “RHEA:51884”
amino-acid racemase activity narrowMatch 59404
amino-acid racemase activity database_cross_reference “RHEA:60516”
amino-acid racemase activity narrowMatch 59188
amino-acid racemase activity database_cross_reference “RHEA:59276”
amino-acid racemase activity database_cross_reference “RHEA:59396”
amino-acid racemase activity database_cross_reference “RHEA:59280”
amino-acid racemase activity narrowMatch 45560
amino-acid racemase activity narrowMatch 59804
amino-acid racemase activity database_cross_reference “RHEA:59804”
amino-acid racemase activity narrowMatch 51884
amino-acid racemase activity database_cross_reference “RHEA:45560”
amino-acid racemase activity narrowMatch 59396
amino-acid racemase activity database_cross_reference “RHEA:62772”
amino-acid racemase activity database_cross_reference “RHEA:59188”
amino-acid racemase activity narrowMatch 62772
amino-acid racemase activity database_cross_reference “RHEA:59272”
amino-acid racemase activity narrowMatch 60516
amino-acid racemase activity database_cross_reference “RHEA:59404”

aminoacylase activity `http://purl.obolibrary.org/obo/GO_0004046`

Added

aminoacylase activity database_cross_reference “RHEA:52628”
aminoacylase activity database_cross_reference “RHEA:54184”
aminoacylase activity narrowMatch 67368
aminoacylase activity narrowMatch 81123
aminoacylase activity database_cross_reference “RHEA:36855”
aminoacylase activity database_cross_reference “RHEA:81123”
aminoacylase activity narrowMatch 54184
aminoacylase activity database_cross_reference “RHEA:81119”
aminoacylase activity database_cross_reference “RHEA:67440”
aminoacylase activity database_cross_reference “RHEA:75515”
aminoacylase activity narrowMatch 52628
aminoacylase activity narrowMatch 67440
aminoacylase activity narrowMatch 81119
aminoacylase activity database_cross_reference “RHEA:67368”
aminoacylase activity narrowMatch 75515
aminoacylase activity narrowMatch 36855
aminoacylase activity database_cross_reference “RHEA:81115”
aminoacylase activity narrowMatch 81115

aminodeoxychorismate synthase activity `http://purl.obolibrary.org/obo/GO_0046820`

Removed

aminodeoxychorismate synthase activity has_related_synonym “aminodeoxychorismate synthase activity”
aminodeoxychorismate synthase activity label “4-amino-4-deoxychorismate synthase activity”

Added

aminodeoxychorismate synthase activity has_exact_synonym “4-amino-4-deoxychorismate synthase activity”
aminodeoxychorismate synthase activity label “aminodeoxychorismate synthase activity”
aminodeoxychorismate synthase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI

aminoimidazolase activity `http://purl.obolibrary.org/obo/GO_0047664`

Removed

aminoimidazolase activity definition “Catalysis of the reaction:4-aminoimidazole + H20 = imidazol-4-one + NH3.”
- database_cross_reference “RHEA:22348”

Added

aminoimidazolase activity definition “Catalysis of the reaction: 4-aminoimidazole + H2O + H+ = imidazol-4-one + NH4+.”
- database_cross_reference “RHEA:22348”

aminolevulinate:pyruvate transaminase activity `http://purl.obolibrary.org/obo/GO_0047665`

Removed

aminolevulinate:pyruvate transaminase activity has_exact_synonym “aminolevulinate aminotransferase activity”
aminolevulinate:pyruvate transaminase activity label “aminolevulinate transaminase activity”
aminolevulinate:pyruvate transaminase activity definition “Catalysis of the reaction: 5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine.”
- database_cross_reference “RHEA:12480”
- database_cross_reference “EC:2.6.1.43”

Added

aminolevulinate:pyruvate transaminase activity label “aminolevulinate:pyruvate transaminase activity”
aminolevulinate:pyruvate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
aminolevulinate:pyruvate transaminase activity has_broad_synonym “aminolevulinate aminotransferase activity”
aminolevulinate:pyruvate transaminase activity definition “Catalysis of the reaction: 5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine.”
- database_cross_reference “RHEA:12480”

aminophospholipid flippase activity `http://purl.obolibrary.org/obo/GO_0015247`

Removed

aminophospholipid flippase activity SubClassOf obsolete phospholipid transporter activity

ammeline aminohydrolase activity `http://purl.obolibrary.org/obo/GO_0018756`

Removed

ammeline aminohydrolase activity definition “Catalysis of the reaction: ammeline + H2O = ammelide + NH3.”
- database_cross_reference “PMID:1991731”
ammeline aminohydrolase activity exactMatch 26201

Added

ammeline aminohydrolase activity exactMatch 3.5.4.45
ammeline aminohydrolase activity narrowMatch 26201
ammeline aminohydrolase activity definition “Catalysis of the reaction: ammeline + H2O = ammelide + NH4+. Also converts melamine to ammeline.”
- database_cross_reference “EC:3.5.4.45”
- database_cross_reference “PMID:1991731”
ammeline aminohydrolase activity database_cross_reference “RHEA:26197”
ammeline aminohydrolase activity database_cross_reference “EC:3.5.4.45”
ammeline aminohydrolase activity narrowMatch 26197

ammonia ligase activity `http://purl.obolibrary.org/obo/GO_0016211`

Removed

ammonia ligase activity definition “Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate.”
- database_cross_reference “GOC:jl”

Added

ammonia ligase activity definition “Catalysis of the ligation of ammonia (NH4+) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate.”
- database_cross_reference “GOC:jl”

ammonium transmembrane transport `http://purl.obolibrary.org/obo/GO_0072488`

Added

ammonium transmembrane transport database_cross_reference “Reactome:R-HSA-444411”
- label “Rhesus glycoproteins mediate ammonium transport”

amyloid precursor protein biosynthetic process `http://purl.obolibrary.org/obo/GO_0042983`

Removed

amyloid precursor protein biosynthetic process definition “The chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer’s disease.”
- database_cross_reference “GOC:go_curators”

Added

amyloid precursor protein biosynthetic process definition “The chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer’s disease.”
- database_cross_reference “GOC:curators”

amyloid precursor protein catabolic process `http://purl.obolibrary.org/obo/GO_0042987`

Removed

amyloid precursor protein catabolic process definition “The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer’s disease.”
- database_cross_reference “GOC:go_curators”

Added

amyloid precursor protein catabolic process definition “The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer’s disease.”
- database_cross_reference “GOC:curators”

amyloid precursor protein metabolic process `http://purl.obolibrary.org/obo/GO_0042982`

Removed

amyloid precursor protein metabolic process definition “The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer’s disease.”
- database_cross_reference “GOC:go_curators”

Added

amyloid precursor protein metabolic process definition “The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer’s disease.”
- database_cross_reference “GOC:curators”

anaerobic cobalamin biosynthetic process `http://purl.obolibrary.org/obo/GO_0019251`

Removed

anaerobic cobalamin biosynthetic process definition “The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the absence of oxygen.”
- database_cross_reference “GOC:go_curators”
anaerobic cobalamin biosynthetic process database_cross_reference “MetaCyc:COBALSYN-PWY”

Added

anaerobic cobalamin biosynthetic process database_cross_reference “MetaCyc:PWY-5507”
anaerobic cobalamin biosynthetic process definition “The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the absence of oxygen.”
- database_cross_reference “GOC:curators”
anaerobic cobalamin biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI

anatomical structure arrangement `http://purl.obolibrary.org/obo/GO_0048532`

Removed

anatomical structure arrangement definition “The process that gives rise to the configuration of the constituent parts of an anatomical structure. This process pertains to the physical shaping of a rudimentary structure. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.”
- database_cross_reference “GOC:go_curators”

Added

anatomical structure arrangement definition “The process that gives rise to the configuration of the constituent parts of an anatomical structure. This process pertains to the physical shaping of a rudimentary structure. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.”
- database_cross_reference “GOC:curators”

anatomical structure morphogenesis `http://purl.obolibrary.org/obo/GO_0009653`

Removed

anatomical structure morphogenesis definition “The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0521436125”

Added

anatomical structure morphogenesis definition “The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0521436125”

androecium development `http://purl.obolibrary.org/obo/GO_0048466`

Removed

androecium development definition “The process whose specific outcome is the progression of the androecium over time, from its formation to the mature structure.”
- database_cross_reference “GOC:go_curators”

Added

androecium development definition “The process whose specific outcome is the progression of the androecium over time, from its formation to the mature structure.”
- database_cross_reference “GOC:curators”

androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0047044`

Added

angiogenin-PRI complex `http://purl.obolibrary.org/obo/GO_0032311`

Removed

angiogenin-PRI complex SubClassOf protein-containing complex
angiogenin-PRI complex SubClassOf part of some extracellular region

Added

angiogenin-PRI complex SubClassOf extracellular protein-containing complex

animal organ morphogenesis `http://purl.obolibrary.org/obo/GO_0009887`

Removed

animal organ morphogenesis definition “Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:dgh”
- database_cross_reference “ISBN:0471245208”
- database_cross_reference “ISBN:0721662544”

Added

animal organ morphogenesis definition “Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:dgh”
- database_cross_reference “ISBN:0471245208”
- database_cross_reference “ISBN:0721662544”

anterior midgut (ectodermal) morphogenesis `http://purl.obolibrary.org/obo/GO_0007441`

Removed

anterior midgut (ectodermal) morphogenesis definition “The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized.”
- database_cross_reference “GOC:go_curators”

Added

anterior midgut (ectodermal) morphogenesis definition “The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized.”
- database_cross_reference “GOC:curators”

anterior/posterior axis specification `http://purl.obolibrary.org/obo/GO_0009948`

Removed

anterior/posterior axis specification definition “The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

anterior/posterior axis specification definition “The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

anterior/posterior pattern specification `http://purl.obolibrary.org/obo/GO_0009952`

Removed

anterior/posterior pattern specification definition “The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:isa_complete”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

anterior/posterior pattern specification definition “The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:isa_complete”
- database_cross_reference “GOC:tb”

anthocyanidin 3-O-glucosyltransferase activity `http://purl.obolibrary.org/obo/GO_0047213`

Added

anthocyanidin 3-O-glucosyltransferase activity narrowMatch 60100
anthocyanidin 3-O-glucosyltransferase activity database_cross_reference “RHEA:74139”
anthocyanidin 3-O-glucosyltransferase activity database_cross_reference “RHEA:61504”
anthocyanidin 3-O-glucosyltransferase activity narrowMatch 61508
anthocyanidin 3-O-glucosyltransferase activity database_cross_reference “RHEA:61508”
anthocyanidin 3-O-glucosyltransferase activity narrowMatch 61512
anthocyanidin 3-O-glucosyltransferase activity database_cross_reference “RHEA:60100”
anthocyanidin 3-O-glucosyltransferase activity narrowMatch 61504
anthocyanidin 3-O-glucosyltransferase activity narrowMatch 74139
anthocyanidin 3-O-glucosyltransferase activity database_cross_reference “RHEA:61500”
anthocyanidin 3-O-glucosyltransferase activity narrowMatch 61500
anthocyanidin 3-O-glucosyltransferase activity database_cross_reference “RHEA:61512”

anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity `http://purl.obolibrary.org/obo/GO_0018618`

Removed

anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity definition “Catalysis of the reaction: anthranilate + NADPH + H+ + O2 = catechol + CO2 + NADP+ + NH3.”
- database_cross_reference “EC:1.14.12.1”

Added

anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity definition “Catalysis of the reaction: anthranilate + NAD(P)H + O2 + 3 H+ = catechol + NH4+ + CO2 + NAD(P)+.”
- database_cross_reference “EC:1.14.12.1”

anthranilate catabolic process `http://purl.obolibrary.org/obo/GO_0043421`

Removed

anthranilate catabolic process SubClassOf obsolete anthranilate metabolic process

Added

anthranilate catabolic process database_cross_reference “MetaCyc:PWY-6079”
anthranilate catabolic process database_cross_reference “MetaCyc:PWY-6504”
anthranilate catabolic process database_cross_reference “MetaCyc:PWY-6077”
anthranilate catabolic process narrowMatch PWY-6079
anthranilate catabolic process narrowMatch PWY-6504
anthranilate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
anthranilate catabolic process database_cross_reference “UM-BBD_pathwayID:abz2”
anthranilate catabolic process database_cross_reference “UM-BBD_pathwayID:abz”
anthranilate catabolic process narrowMatch PWY-6077
anthranilate catabolic process narrowMatch AMINOBENZDEG-PWY
anthranilate catabolic process SubClassOf benzene-containing compound metabolic process

anthranilate-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0018860`

Removed

anthranilate-CoA ligase activity SubClassOf acid-thiol ligase activity

antibacterial humoral response `http://purl.obolibrary.org/obo/GO_0019731`

Removed

antibacterial humoral response definition “An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_sensu”

Added

antibacterial humoral response definition “An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_sensu”

antibiotic biosynthetic process `http://purl.obolibrary.org/obo/GO_0017000`

Removed

antibiotic biosynthetic process definition “The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.”
- database_cross_reference “GOC:go_curators”

Added

antibiotic biosynthetic process definition “The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.”
- database_cross_reference “GOC:curators”

antibiotic catabolic process `http://purl.obolibrary.org/obo/GO_0017001`

Removed

antibiotic catabolic process definition “The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.”
- database_cross_reference “GOC:go_curators”

Added

antibiotic catabolic process definition “The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.”
- database_cross_reference “GOC:curators”

antifungal humoral response `http://purl.obolibrary.org/obo/GO_0019732`

Removed

antifungal humoral response definition “An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_sensu”

Added

antifungal humoral response definition “An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_sensu”

antimicrobial humoral response `http://purl.obolibrary.org/obo/GO_0019730`

Removed

antimicrobial humoral response definition “An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_sensu”

Added

antimicrobial humoral response definition “An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_sensu”

apical junction assembly `http://purl.obolibrary.org/obo/GO_0043297`

Removed

apical junction assembly definition “The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:14729475”
- database_cross_reference “PMID:15196556”
- database_cross_reference “PMID:10854689”

Added

apical junction assembly definition “The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:14729475”
- database_cross_reference “PMID:15196556”
- database_cross_reference “PMID:10854689”

apical junction complex `http://purl.obolibrary.org/obo/GO_0043296`

Removed

apical junction complex definition “A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:15196556”
- database_cross_reference “PMID:12525486”
- database_cross_reference “GOC:kmv”

Added

apical junction complex definition “A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:15196556”
- database_cross_reference “PMID:12525486”
- database_cross_reference “GOC:kmv”

apoplast `http://purl.obolibrary.org/obo/GO_0048046`

Removed

apoplast SubClassOf extracellular region

Added

apoplast term tracker item “https://github.com/geneontology/go-ontology/issues/31720”^^anyURI
apoplast SubClassOf cellular anatomical structure
apoplast SubClassOf part of some extracellular region

apoptotic process `http://purl.obolibrary.org/obo/GO_0006915`

Removed

apoptotic process definition “A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.”
- database_cross_reference “PMID:18846107”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:cjm”
- database_cross_reference “GOC:ecd”
- database_cross_reference “PMID:21494263”
- database_cross_reference “GOC:dhl”
- database_cross_reference “GOC:mtg_apoptosis”
- database_cross_reference “ISBN:0198506732”

Added

apoptotic process definition “A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:18846107”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:cjm”
- database_cross_reference “GOC:ecd”
- database_cross_reference “PMID:21494263”
- database_cross_reference “GOC:dhl”
- database_cross_reference “GOC:mtg_apoptosis”
- database_cross_reference “ISBN:0198506732”

apoptotic signaling pathway `http://purl.obolibrary.org/obo/GO_0097190`

Added

apoptotic signaling pathway database_cross_reference “Reactome:R-HSA-111459”
- label “Activation of caspases through apoptosome-mediated cleavage”

apyrase activity `http://purl.obolibrary.org/obo/GO_0004050`

Added

apyrase activity database_cross_reference “RHEA:77735”
apyrase activity narrowMatch 77735
apyrase activity database_cross_reference “RHEA:64908”
apyrase activity narrowMatch 64896
apyrase activity database_cross_reference “RHEA:64904”
apyrase activity narrowMatch 64908
apyrase activity database_cross_reference “RHEA:64896”
apyrase activity narrowMatch 20988
apyrase activity narrowMatch 64904
apyrase activity database_cross_reference “RHEA:20988”

arachidonate 11,12-epoxygenase activity `http://purl.obolibrary.org/obo/GO_0008405`

Added

arachidonate 11,12-epoxygenase activity narrowMatch 49880
arachidonate 11,12-epoxygenase activity narrowMatch 49876
arachidonate 11,12-epoxygenase activity database_cross_reference “RHEA:49876”
arachidonate 11,12-epoxygenase activity database_cross_reference “RHEA:49880”

arachidonate 14,15-epoxygenase activity `http://purl.obolibrary.org/obo/GO_0008404`

Added

arachidonate 14,15-epoxygenase activity narrowMatch 49860
arachidonate 14,15-epoxygenase activity database_cross_reference “RHEA:49860”
arachidonate 14,15-epoxygenase activity database_cross_reference “RHEA:49856”
arachidonate 14,15-epoxygenase activity narrowMatch 49856

arachidonate 8,9-epoxygenase activity `http://purl.obolibrary.org/obo/GO_0106302`

Added

arachidonate 8,9-epoxygenase activity narrowMatch 49884
arachidonate 8,9-epoxygenase activity narrowMatch 49928
arachidonate 8,9-epoxygenase activity database_cross_reference “RHEA:49928”
arachidonate 8,9-epoxygenase activity database_cross_reference “RHEA:49884”

aralkylamine N-acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0004059`

Added

aralkylamine N-acetyltransferase activity database_cross_reference “RHEA:25217”
aralkylamine N-acetyltransferase activity database_cross_reference “RHEA:66144”
aralkylamine N-acetyltransferase activity narrowMatch 66152
aralkylamine N-acetyltransferase activity database_cross_reference “RHEA:66148”
aralkylamine N-acetyltransferase activity database_cross_reference “RHEA:51388”
aralkylamine N-acetyltransferase activity database_cross_reference “RHEA:66196”
aralkylamine N-acetyltransferase activity narrowMatch 25217
aralkylamine N-acetyltransferase activity narrowMatch 66196
aralkylamine N-acetyltransferase activity database_cross_reference “RHEA:66136”
aralkylamine N-acetyltransferase activity narrowMatch 66148
aralkylamine N-acetyltransferase activity database_cross_reference “RHEA:66140”
aralkylamine N-acetyltransferase activity narrowMatch 66144
aralkylamine N-acetyltransferase activity narrowMatch 66140
aralkylamine N-acetyltransferase activity narrowMatch 51388
aralkylamine N-acetyltransferase activity database_cross_reference “RHEA:66152”
aralkylamine N-acetyltransferase activity narrowMatch 66136

aralkylamine dehydrogenase (azurin) activity `http://purl.obolibrary.org/obo/GO_0030059`

Added

arginase activity `http://purl.obolibrary.org/obo/GO_0004053`

Added

arginase activity database_cross_reference “Reactome:R-HSA-9956512”
- label “ARG1 variants don’t synthesize urea and ornithine”

arginine deiminase activity `http://purl.obolibrary.org/obo/GO_0016990`

Removed

arginine deiminase activity definition “Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH3.”
- database_cross_reference “EC:3.5.3.6”

Added

arginine deiminase activity definition “Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH4+.”
- database_cross_reference “RHEA:19597”

arginine metabolic process `http://purl.obolibrary.org/obo/GO_0006525`

Removed

arginine metabolic process definition “The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.”
- database_cross_reference “GOC:go_curators”

Added

arginine metabolic process definition “The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.”
- database_cross_reference “GOC:curators”

argininosuccinate lyase activity `http://purl.obolibrary.org/obo/GO_0004056`

Added

argininosuccinate lyase activity database_cross_reference “Reactome:R-HSA-9956524”
- label “ASL variants don’t synthesize fumarate and arginine”

argininosuccinate synthase activity `http://purl.obolibrary.org/obo/GO_0004055`

Added

argininosuccinate synthase activity database_cross_reference “Reactome:R-HSA-9956517”
- label “ASS1 variants don’t synthesize arginosuccinate”

aromatic (S)-hydroxynitrile lyase activity `http://purl.obolibrary.org/obo/GO_0052892`

Added

aromatic (S)-hydroxynitrile lyase activity database_cross_reference “RHEA:77515”
aromatic (S)-hydroxynitrile lyase activity database_cross_reference “RHEA:77447”
aromatic (S)-hydroxynitrile lyase activity narrowMatch 77511
aromatic (S)-hydroxynitrile lyase activity database_cross_reference “RHEA:77463”
aromatic (S)-hydroxynitrile lyase activity narrowMatch 77459
aromatic (S)-hydroxynitrile lyase activity narrowMatch 77463
aromatic (S)-hydroxynitrile lyase activity database_cross_reference “RHEA:77455”
aromatic (S)-hydroxynitrile lyase activity narrowMatch 77515
aromatic (S)-hydroxynitrile lyase activity database_cross_reference “RHEA:77427”
aromatic (S)-hydroxynitrile lyase activity narrowMatch 77451
aromatic (S)-hydroxynitrile lyase activity narrowMatch 77455
aromatic (S)-hydroxynitrile lyase activity narrowMatch 77519
aromatic (S)-hydroxynitrile lyase activity narrowMatch 77507
aromatic (S)-hydroxynitrile lyase activity narrowMatch 77499
aromatic (S)-hydroxynitrile lyase activity database_cross_reference “RHEA:77451”
aromatic (S)-hydroxynitrile lyase activity narrowMatch 77503
aromatic (S)-hydroxynitrile lyase activity database_cross_reference “RHEA:77507”
aromatic (S)-hydroxynitrile lyase activity database_cross_reference “RHEA:77511”
aromatic (S)-hydroxynitrile lyase activity database_cross_reference “RHEA:77499”
aromatic (S)-hydroxynitrile lyase activity database_cross_reference “RHEA:77503”
aromatic (S)-hydroxynitrile lyase activity narrowMatch 77427
aromatic (S)-hydroxynitrile lyase activity database_cross_reference “RHEA:77519”
aromatic (S)-hydroxynitrile lyase activity database_cross_reference “RHEA:77459”
aromatic (S)-hydroxynitrile lyase activity narrowMatch 77447

aromatic amino acid family biosynthetic process `http://purl.obolibrary.org/obo/GO_0009073`

Removed

aromatic amino acid family biosynthetic process definition “The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).”
- database_cross_reference “GOC:go_curators”

Added

aromatic amino acid family biosynthetic process definition “The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).”
- database_cross_reference “GOC:curators”

aromatic amino acid family catabolic process `http://purl.obolibrary.org/obo/GO_0009074`

Removed

aromatic amino acid family catabolic process definition “The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).”
- database_cross_reference “GOC:go_curators”

Added

aromatic amino acid family catabolic process definition “The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).”
- database_cross_reference “GOC:curators”

aromatic amino acid metabolic process `http://purl.obolibrary.org/obo/GO_0009072`

Removed

aromatic amino acid metabolic process definition “The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).”
- database_cross_reference “GOC:go_curators”

Added

aromatic amino acid metabolic process definition “The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).”
- database_cross_reference “GOC:curators”

aromatic-amino-acid:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0008793`

Removed

aromatic-amino-acid:2-oxoglutarate transaminase activity label “aromatic-amino-acid transaminase activity”
aromatic-amino-acid:2-oxoglutarate transaminase activity broadMatch 2.6.1.57
aromatic-amino-acid:2-oxoglutarate transaminase activity SubClassOf transaminase activity

Added

aromatic-amino-acid:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
aromatic-amino-acid:2-oxoglutarate transaminase activity has_broad_synonym “aromatic-amino-acid transaminase activity”
aromatic-amino-acid:2-oxoglutarate transaminase activity exactMatch 2.6.1.57
aromatic-amino-acid:2-oxoglutarate transaminase activity label “aromatic-amino-acid:2-oxoglutarate transaminase activity”
aromatic-amino-acid:2-oxoglutarate transaminase activity database_cross_reference “EC:2.6.1.57”
aromatic-amino-acid:2-oxoglutarate transaminase activity SubClassOf amino acid transaminase activity

aromatic-amino-acid:glyoxylate transaminase activity `http://purl.obolibrary.org/obo/GO_0047313`

Removed

aromatic-amino-acid:glyoxylate transaminase activity definition “Catalysis of the reaction: glyoxylate + an aromatic amino acid = L-glycine + an aromatic oxo acid.”
- database_cross_reference “MetaCyc:2.6.1.60-RXN”
- database_cross_reference “EC:2.6.1.60”
aromatic-amino-acid:glyoxylate transaminase activity label “aromatic-amino-acid-glyoxylate transaminase activity”
aromatic-amino-acid:glyoxylate transaminase activity SubClassOf transaminase activity

Added

aromatic-amino-acid:glyoxylate transaminase activity narrowMatch 69116
aromatic-amino-acid:glyoxylate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
aromatic-amino-acid:glyoxylate transaminase activity database_cross_reference “RHEA:69124”
aromatic-amino-acid:glyoxylate transaminase activity database_cross_reference “RHEA:69120”
aromatic-amino-acid:glyoxylate transaminase activity narrowMatch 69124
aromatic-amino-acid:glyoxylate transaminase activity label “aromatic-amino-acid:glyoxylate transaminase activity”
aromatic-amino-acid:glyoxylate transaminase activity has_exact_synonym “aromatic-amino-acid-glyoxylate transaminase activity”
aromatic-amino-acid:glyoxylate transaminase activity narrowMatch 69120
aromatic-amino-acid:glyoxylate transaminase activity definition “Catalysis of the reaction: an aromatic L-alpha-amino acid + glyoxylate = an aromatic oxo-acid + glycine.”
- database_cross_reference “RHEA:10900”
aromatic-amino-acid:glyoxylate transaminase activity database_cross_reference “RHEA:69116”
aromatic-amino-acid:glyoxylate transaminase activity SubClassOf amino acid transaminase activity

aryl sulfotransferase activity `http://purl.obolibrary.org/obo/GO_0004062`

Added

aryl sulfotransferase activity narrowMatch 66576
aryl sulfotransferase activity database_cross_reference “RHEA:66548”
aryl sulfotransferase activity narrowMatch 83343
aryl sulfotransferase activity narrowMatch 66572
aryl sulfotransferase activity database_cross_reference “RHEA:66576”
aryl sulfotransferase activity narrowMatch 67876
aryl sulfotransferase activity narrowMatch 67888
aryl sulfotransferase activity database_cross_reference “RHEA:83351”
aryl sulfotransferase activity narrowMatch 83575
aryl sulfotransferase activity database_cross_reference “RHEA:66580”
aryl sulfotransferase activity database_cross_reference “RHEA:83575”
aryl sulfotransferase activity database_cross_reference “RHEA:67892”
aryl sulfotransferase activity database_cross_reference “RHEA:66572”
aryl sulfotransferase activity narrowMatch 83351
aryl sulfotransferase activity narrowMatch 67892
aryl sulfotransferase activity narrowMatch 66548
aryl sulfotransferase activity database_cross_reference “RHEA:67888”
aryl sulfotransferase activity database_cross_reference “RHEA:83343”
aryl sulfotransferase activity narrowMatch 66580
aryl sulfotransferase activity database_cross_reference “RHEA:67876”

aryl-alcohol dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0018456`

Added

aryl-alcohol dehydrogenase (NAD+) activity database_cross_reference “RHEA:65044”
aryl-alcohol dehydrogenase (NAD+) activity narrowMatch 65048
aryl-alcohol dehydrogenase (NAD+) activity narrowMatch 64696
aryl-alcohol dehydrogenase (NAD+) activity narrowMatch 65052
aryl-alcohol dehydrogenase (NAD+) activity database_cross_reference “RHEA:64696”
aryl-alcohol dehydrogenase (NAD+) activity database_cross_reference “RHEA:65052”
aryl-alcohol dehydrogenase (NAD+) activity database_cross_reference “RHEA:65048”
aryl-alcohol dehydrogenase (NAD+) activity narrowMatch 65044

aryl-alcohol dehydrogenase (NADP+) activity `http://purl.obolibrary.org/obo/GO_0047681`

Added

aryl-alcohol oxidase activity `http://purl.obolibrary.org/obo/GO_0047682`

Added

aryl-alcohol oxidase activity narrowMatch 80455
aryl-alcohol oxidase activity database_cross_reference “RHEA:80379”
aryl-alcohol oxidase activity narrowMatch 80435
aryl-alcohol oxidase activity narrowMatch 80443
aryl-alcohol oxidase activity database_cross_reference “RHEA:80467”
aryl-alcohol oxidase activity narrowMatch 80459
aryl-alcohol oxidase activity database_cross_reference “RHEA:80443”
aryl-alcohol oxidase activity narrowMatch 80447
aryl-alcohol oxidase activity database_cross_reference “RHEA:80431”
aryl-alcohol oxidase activity database_cross_reference “RHEA:80463”
aryl-alcohol oxidase activity narrowMatch 80431
aryl-alcohol oxidase activity narrowMatch 80451
aryl-alcohol oxidase activity database_cross_reference “RHEA:80383”
aryl-alcohol oxidase activity narrowMatch 80383
aryl-alcohol oxidase activity database_cross_reference “RHEA:80455”
aryl-alcohol oxidase activity database_cross_reference “RHEA:80435”
aryl-alcohol oxidase activity narrowMatch 80379
aryl-alcohol oxidase activity narrowMatch 80467
aryl-alcohol oxidase activity database_cross_reference “RHEA:80439”
aryl-alcohol oxidase activity narrowMatch 80439
aryl-alcohol oxidase activity database_cross_reference “RHEA:80459”
aryl-alcohol oxidase activity database_cross_reference “RHEA:80447”
aryl-alcohol oxidase activity narrowMatch 80463
aryl-alcohol oxidase activity database_cross_reference “RHEA:80451”

aryl-aldehyde dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0019108`

Added

aryl-aldehyde dehydrogenase (NAD+) activity narrowMatch 57936
aryl-aldehyde dehydrogenase (NAD+) activity narrowMatch 36311
aryl-aldehyde dehydrogenase (NAD+) activity narrowMatch 19693
aryl-aldehyde dehydrogenase (NAD+) activity narrowMatch 80375
aryl-aldehyde dehydrogenase (NAD+) activity narrowMatch 80367
aryl-aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:19693”
aryl-aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:80363”
aryl-aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:36311”
aryl-aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:80375”
aryl-aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:57936”
aryl-aldehyde dehydrogenase (NAD+) activity narrowMatch 80363
aryl-aldehyde dehydrogenase (NAD+) activity narrowMatch 80371
aryl-aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:80367”
aryl-aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:80371”

aryl-aldehyde dehydrogenase (NADP+) activity `http://purl.obolibrary.org/obo/GO_0047683`

Added

aryl-aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:68896”
aryl-aldehyde dehydrogenase (NADP+) activity narrowMatch 68868
aryl-aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:68876”
aryl-aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:68884”
aryl-aldehyde dehydrogenase (NADP+) activity narrowMatch 68904
aryl-aldehyde dehydrogenase (NADP+) activity narrowMatch 68892
aryl-aldehyde dehydrogenase (NADP+) activity narrowMatch 68876
aryl-aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:68908”
aryl-aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:68872”
aryl-aldehyde dehydrogenase (NADP+) activity narrowMatch 68896
aryl-aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:68880”
aryl-aldehyde dehydrogenase (NADP+) activity narrowMatch 68900
aryl-aldehyde dehydrogenase (NADP+) activity narrowMatch 68872
aryl-aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:68904”
aryl-aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:68868”
aryl-aldehyde dehydrogenase (NADP+) activity narrowMatch 68884
aryl-aldehyde dehydrogenase (NADP+) activity narrowMatch 68908
aryl-aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:68892”
aryl-aldehyde dehydrogenase (NADP+) activity narrowMatch 68880
aryl-aldehyde dehydrogenase (NADP+) activity narrowMatch 68888
aryl-aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:68900”
aryl-aldehyde dehydrogenase (NADP+) activity database_cross_reference “RHEA:68888”

aryl-aldehyde oxidase activity `http://purl.obolibrary.org/obo/GO_0018488`

Removed

aryl-aldehyde oxidase activity definition “Catalysis of the reaction: an aromatic aldehyde + O2 + H2O = an aromatic acid + hydrogen peroxide.”
- database_cross_reference “EC:1.2.3.9”

Added

aryl-aldehyde oxidase activity narrowMatch 59008
aryl-aldehyde oxidase activity narrowMatch 58996
aryl-aldehyde oxidase activity database_cross_reference “RHEA:58996”
aryl-aldehyde oxidase activity database_cross_reference “RHEA:58972”
aryl-aldehyde oxidase activity narrowMatch 58968
aryl-aldehyde oxidase activity narrowMatch 58992
aryl-aldehyde oxidase activity database_cross_reference “RHEA:58960”
aryl-aldehyde oxidase activity narrowMatch 58972
aryl-aldehyde oxidase activity narrowMatch 58960
aryl-aldehyde oxidase activity definition “Catalysis of the reaction: an aromatic aldehyde + O2 + H2O = an aromatic carboxylate + H2O2 + H+.”
- database_cross_reference “RHEA:18569”
aryl-aldehyde oxidase activity database_cross_reference “RHEA:59008”
aryl-aldehyde oxidase activity database_cross_reference “RHEA:58992”
aryl-aldehyde oxidase activity database_cross_reference “RHEA:58968”

arylacetonitrilase activity `http://purl.obolibrary.org/obo/GO_0047428`

Removed

arylacetonitrilase activity definition “Catalysis of the reaction: 2 H2O + 4-chlorophenylacetonitrile = 4-chlorophenylacetate + NH3.”
- database_cross_reference “EC:3.5.5.5”

Added

arylacetonitrilase activity definition “Catalysis of the reaction: 4-chlorophenylacetonitrile + 2 H2O = 4-chlorophenylacetate + NH4+.”
- database_cross_reference “RHEA:20657”

arylalkyl acylamidase activity `http://purl.obolibrary.org/obo/GO_0047416`

Added

arylalkyl acylamidase activity narrowMatch 67200
arylalkyl acylamidase activity database_cross_reference “RHEA:67204”
arylalkyl acylamidase activity narrowMatch 67208
arylalkyl acylamidase activity database_cross_reference “RHEA:67196”
arylalkyl acylamidase activity narrowMatch 67204
arylalkyl acylamidase activity database_cross_reference “RHEA:67208”
arylalkyl acylamidase activity database_cross_reference “RHEA:67200”
arylalkyl acylamidase activity narrowMatch 67196

arylamine N-acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0004060`

Added

arylamine N-acetyltransferase activity narrowMatch 56316
arylamine N-acetyltransferase activity database_cross_reference “RHEA:14241”
arylamine N-acetyltransferase activity narrowMatch 14241
arylamine N-acetyltransferase activity database_cross_reference “RHEA:56316”

arylsulfate sulfotransferase activity `http://purl.obolibrary.org/obo/GO_0047686`

Added

arylsulfate sulfotransferase activity narrowMatch 79267
arylsulfate sulfotransferase activity narrowMatch 79263
arylsulfate sulfotransferase activity database_cross_reference “RHEA:79263”
arylsulfate sulfotransferase activity database_cross_reference “RHEA:79267”

ascorbate glutathione cycle `http://purl.obolibrary.org/obo/GO_0033355`

Removed

ascorbate glutathione cycle definition “A cyclic series of interconversions involving L-ascorbate and glutathione that scavenges hydrogen peroxide and reduces it to water, with concomitant oxidation of NADPH.”
- database_cross_reference “GOC:mah”
- database_cross_reference “MetaCyc:PWY-2261”

Added

ascorbate glutathione cycle definition “A cyclic series of interconversions involving L-ascorbate and glutathione that scavenges H2O2 and reduces it to water, with concomitant oxidation of NADPH.”
- database_cross_reference “GOC:mah”
- database_cross_reference “MetaCyc:PWY-2261”

ascospore wall `http://purl.obolibrary.org/obo/GO_0005619`

Removed

ascospore wall definition “The specialized cell wall of the ascospore (spore), which is the product of meiotic division. Examples of this component are found in Fungi.”
- database_cross_reference “GOC:vw”
- database_cross_reference “ISBN:0879693568”

Added

ascospore wall definition “The specialized cell wall of the ascospore (spore), which is the product of meiotic division. Examples of this component are found in Fungi.”
- database_cross_reference “PMID:36266346”
- database_cross_reference “GOC:vw”

ascospore-type prospore `http://purl.obolibrary.org/obo/GO_0042764`

Removed

ascospore-type prospore definition “An immature spore undergoing development. The spore usually consists of nucleic acid, prospore membrane(s) that encase the nucleic acid, and ultimately a cell wall that covers the membrane(s). This type of spore is observed in ascospore-forming fungi.”
- database_cross_reference “GOC:go_curators”

Added

ascospore-type prospore definition “An immature spore undergoing development. The spore usually consists of nucleic acid, prospore membrane(s) that encase the nucleic acid, and ultimately a cell wall that covers the membrane(s). This type of spore is observed in ascospore-forming fungi.”
- database_cross_reference “GOC:curators”

asparagine metabolic process `http://purl.obolibrary.org/obo/GO_0006528`

Removed

asparagine metabolic process definition “The chemical reactions and pathways involving asparagine, 2-amino-3-carbamoylpropanoic acid.”
- database_cross_reference “GOC:go_curators”
asparagine metabolic process database_cross_reference “MetaCyc:ASPARAGINESYN-PWY”

Added

asparagine metabolic process definition “The chemical reactions and pathways involving asparagine, 2-amino-3-carbamoylpropanoic acid.”
- database_cross_reference “GOC:curators”

aspartate 1-decarboxylase activity `http://purl.obolibrary.org/obo/GO_0004068`

Removed

aspartate 1-decarboxylase activity comment “Note that this term has a MetaCyc pathway reference as the pathway only has a single step.”
aspartate 1-decarboxylase activity relatedMatch PWY-5155

Added

aspartate 1-decarboxylase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI

aspartate ammonia-lyase activity `http://purl.obolibrary.org/obo/GO_0008797`

Removed

aspartate ammonia-lyase activity definition “Catalysis of the reaction: L-aspartate = fumarate + NH3.”
- database_cross_reference “EC:4.3.1.1”

Added

aspartate ammonia-lyase activity definition “Catalysis of the reaction: L-aspartate = fumarate + NH4+.”
- database_cross_reference “RHEA:16601”

aspartate family amino acid biosynthetic process `http://purl.obolibrary.org/obo/GO_0009067`

Removed

aspartate family amino acid biosynthetic process database_cross_reference “MetaCyc:PWY0-781”
aspartate family amino acid biosynthetic process exactMatch PWY0-781
aspartate family amino acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine.”
- database_cross_reference “MetaCyc:PWY0-781”
- database_cross_reference “GOC:ai”

Added

aspartate family amino acid biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
aspartate family amino acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine.”
- database_cross_reference “GOC:ai”

aspartate metabolic process `http://purl.obolibrary.org/obo/GO_0006531`

Removed

aspartate metabolic process definition “The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

aspartate metabolic process definition “The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

aspartate transmembrane transport `http://purl.obolibrary.org/obo/GO_0015810`

Removed

aspartate transmembrane transport definition “The process in which aspartate is transported across a lipid bilayer, from one side of a membrane to the other.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

aspartate transmembrane transport definition “The process in which aspartate is transported across a lipid bilayer, from one side of a membrane to the other.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

aspartate-ammonia ligase activity `http://purl.obolibrary.org/obo/GO_0004071`

Removed

aspartate-ammonia ligase activity definition “Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine.”
- database_cross_reference “EC:6.3.1.1”

Added

aspartate-ammonia ligase activity definition “Catalysis of the reaction: ATP + L-aspartate + NH4+ = AMP + diphosphate + L-asparagine.”
- database_cross_reference “RHEA:11372”

aspartic-type endopeptidase activity `http://purl.obolibrary.org/obo/GO_0004190`

Removed

aspartic-type endopeptidase activity database_cross_reference “Reactome:R-HSA-2022403”
- label “Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)”
aspartic-type endopeptidase activity database_cross_reference “Reactome:R-HSA-2022412”
- label “Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10)”
aspartic-type endopeptidase activity database_cross_reference “Reactome:R-HSA-2065357”
- label “Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)”

Added

aspartic-type endopeptidase activity database_cross_reference “Reactome:R-HSA-2065357”
- label “Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10))”
aspartic-type endopeptidase activity database_cross_reference “Reactome:R-HSA-2022412”
- label “Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10))”
aspartic-type endopeptidase activity database_cross_reference “Reactome:R-HSA-2022403”
- label “Renin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10))”

aspartoacylase activity `http://purl.obolibrary.org/obo/GO_0019807`

Removed

aspartoacylase activity database_cross_reference “Reactome:R-HSA-5691507”
- label “ASPA deacetylates NAA to acetate and L-aspartate”

Added

aspartoacylase activity database_cross_reference “RHEA:59408”
aspartoacylase activity database_cross_reference “Reactome:R-HSA-5691507”
- label “ASPA deacetylates NAASP to acetate and L-aspartate”
aspartoacylase activity narrowMatch 59408

astrocyte cell migration `http://purl.obolibrary.org/obo/GO_0043615`

Removed

astrocyte cell migration definition “The orderly movement of an astrocyte, a class of large neuroglial (macroglial) cells in the central nervous system, the largest and most numerous neuroglial cells in the brain and spinal cord.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “CL:0000127”

Added

astrocyte cell migration definition “The orderly movement of an astrocyte, a class of large neuroglial (macroglial) cells in the central nervous system, the largest and most numerous neuroglial cells in the brain and spinal cord.”
- database_cross_reference “GOC:curators”
- database_cross_reference “CL:0000127”

auditory receptor cell fate determination `http://purl.obolibrary.org/obo/GO_0042668`

Removed

auditory receptor cell fate determination definition “The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell regardless of its environment; upon determination, the cell fate cannot be reversed.”
- database_cross_reference “GOC:go_curators”

Added

auditory receptor cell fate determination definition “The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell regardless of its environment; upon determination, the cell fate cannot be reversed.”
- database_cross_reference “GOC:curators”

auditory receptor cell fate specification `http://purl.obolibrary.org/obo/GO_0042667`

Removed

auditory receptor cell fate specification definition “The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.”
- database_cross_reference “GOC:go_curators”

Added

auditory receptor cell fate specification definition “The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.”
- database_cross_reference “GOC:curators”

axial mesoderm morphogenesis `http://purl.obolibrary.org/obo/GO_0048319`

Removed

axial mesoderm morphogenesis definition “The process in which the anatomical structures of the axial mesoderm are generated and organized.”
- database_cross_reference “GOC:go_curators”

Added

axial mesoderm morphogenesis definition “The process in which the anatomical structures of the axial mesoderm are generated and organized.”
- database_cross_reference “GOC:curators”

axis specification `http://purl.obolibrary.org/obo/GO_0009798`

Removed

axis specification definition “The establishment, maintenance and elaboration of a pattern along a line or around a point.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:isa_complete”
- database_cross_reference “GOC:go_curators”

Added

axis specification definition “The establishment, maintenance and elaboration of a pattern along a line or around a point.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:isa_complete”

azole transmembrane transport `http://purl.obolibrary.org/obo/GO_0045117`

Removed

azole transmembrane transport definition “The directed movement of azoles, heterocyclic compounds found in many biologically important substances, across a lipid bilayer, across a membrane.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:3527307206”
- database_cross_reference “Wikipedia:Azole”

Added

azole transmembrane transport definition “The directed movement of azoles, heterocyclic compounds found in many biologically important substances, across a lipid bilayer, across a membrane.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:3527307206”
- database_cross_reference “Wikipedia:Azole”

azole transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_1901474`

Removed

azole transmembrane transporter activity definition “Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:3527307206”
- database_cross_reference “Wikipedia:Azole”

Added

azole transmembrane transporter activity definition “Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:3527307206”
- database_cross_reference “Wikipedia:Azole”

backward locomotion `http://purl.obolibrary.org/obo/GO_0043057`

Removed

backward locomotion definition “Posterior movement of an organism, e.g. following the direction of the tail of an animal.”
- database_cross_reference “GOC:go_curators”

Added

backward locomotion definition “Posterior movement of an organism, e.g. following the direction of the tail of an animal.”
- database_cross_reference “GOC:curators”

bacterial-type RNA polymerase holo enzyme binding `http://purl.obolibrary.org/obo/GO_0001108`

Removed

bacterial-type RNA polymerase holo enzyme binding SubClassOf obsolete basal transcription machinery binding

Added

bacterial-type RNA polymerase holo enzyme binding SubClassOf RNA polymerase binding

bacteriochlorophyll catabolic process `http://purl.obolibrary.org/obo/GO_0030495`

Removed

bacteriochlorophyll catabolic process definition “The chemical reactions and pathways resulting in the breakdown of bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants.”
- database_cross_reference “GOC:go_curators”

Added

bacteriochlorophyll catabolic process definition “The chemical reactions and pathways resulting in the breakdown of bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants.”
- database_cross_reference “GOC:curators”

basal plasma membrane `http://purl.obolibrary.org/obo/GO_0009925`

Removed

basal plasma membrane definition “The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.”
- database_cross_reference “GOC:go_curators”

Added

basal plasma membrane definition “The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.”
- database_cross_reference “GOC:curators”

basolateral plasma membrane `http://purl.obolibrary.org/obo/GO_0016323`

Removed

basolateral plasma membrane definition “The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.”
- database_cross_reference “GOC:go_curators”

Added

basolateral plasma membrane definition “The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.”
- database_cross_reference “GOC:curators”

behavioral fear response `http://purl.obolibrary.org/obo/GO_0001662`

Added

behavioral fear response term tracker item “https://github.com/geneontology/go-ontology/issues/31407”^^anyURI

behavioral response to pain `http://purl.obolibrary.org/obo/GO_0048266`

Removed

behavioral response to pain SubClassOf part of some response to pain

Added

behavioral response to pain term tracker item “https://github.com/geneontology/go-ontology/issues/31407”^^anyURI
behavioral response to pain SubClassOf response to pain

behavioral response to starvation `http://purl.obolibrary.org/obo/GO_0042595`

Removed

behavioral response to starvation definition “Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment.”
- database_cross_reference “GOC:go_curators”

Added

behavioral response to starvation definition “Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment.”
- database_cross_reference “GOC:curators”

benzoate-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0018858`

Removed

benzoate-CoA ligase activity SubClassOf acid-thiol ligase activity

beta 2 integrin biosynthetic process `http://purl.obolibrary.org/obo/GO_0045114`

Removed

beta 2 integrin biosynthetic process definition “The chemical reactions and pathways resulting in the formation of beta 2 integrins, a subfamily of integrins which contain the beta 2 subunit.”
- database_cross_reference “GOC:go_curators”

Added

beta 2 integrin biosynthetic process definition “The chemical reactions and pathways resulting in the formation of beta 2 integrins, a subfamily of integrins which contain the beta 2 subunit.”
- database_cross_reference “GOC:curators”

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity `http://purl.obolibrary.org/obo/GO_0047223`

Removed

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity database_cross_reference “Reactome:R-HSA-5617037”
- label “POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1”

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity `http://purl.obolibrary.org/obo/GO_0003829`

Removed

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity database_cross_reference “Reactome:R-HSA-914018”
- label “Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein”

Added

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity narrowMatch 56216
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity database_cross_reference “RHEA:56212”
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity database_cross_reference “RHEA:56216”
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity database_cross_reference “Reactome:R-HSA-914018”
- label “GCNT3 transfers GlcNAc to Core 3 mucin”
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity narrowMatch 56212

beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase activity `http://purl.obolibrary.org/obo/GO_0047288`

Added

beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase activity database_cross_reference “Reactome:R-HSA-981497”
- label “ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position”

beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity `http://purl.obolibrary.org/obo/GO_0003831`

Added

beta-N-acetylhexosaminidase activity `http://purl.obolibrary.org/obo/GO_0004563`

Removed

beta-N-acetylhexosaminidase activity database_cross_reference “Reactome:R-HSA-9035978”
- label “Defective HEXA does not cleave the terminal GalNAc from keratan sulfate”
beta-N-acetylhexosaminidase activity database_cross_reference “Reactome:R-HSA-9638078”
- label “HEXB cleaves the terminal GalNAc from keratan sulfate”
beta-N-acetylhexosaminidase activity database_cross_reference “Reactome:R-HSA-3662344”
- label “Defective HEXB does not cleave the terminal GalNAc from DS”
beta-N-acetylhexosaminidase activity database_cross_reference “Reactome:R-HSA-3656259”
- label “Defective HEXA does not cleave the terminal GalNAc from DS”
beta-N-acetylhexosaminidase activity database_cross_reference “Reactome:R-HSA-2162225”
- label “HEXA cleaves the terminal GalNAc from small HA fragments”
beta-N-acetylhexosaminidase activity database_cross_reference “Reactome:R-HSA-9035983”
- label “Defective HEXB does not cleave the terminal GalNAc from keratan sulfate”
beta-N-acetylhexosaminidase activity database_cross_reference “Reactome:R-HSA-9638076”
- label “HEXB cleaves the terminal GalNAc from small HA fragments”
beta-N-acetylhexosaminidase activity database_cross_reference “Reactome:R-HSA-1638053”
- label “HEXA cleaves the terminal GalNAc from keratan sulfate”

Added

beta-N-acetylhexosaminidase activity database_cross_reference “Reactome:R-HSA-1638053”
- label “HEXA cleaves the terminal GlcNAc from keratan sulfate”
beta-N-acetylhexosaminidase activity database_cross_reference “Reactome:R-HSA-9638078”
- label “HEXB cleaves the terminal GlcNAc from keratan sulfate”
beta-N-acetylhexosaminidase activity database_cross_reference “Reactome:R-HSA-2162225”
- label “HEXA cleaves the terminal GlcNAc from small HA fragments”
beta-N-acetylhexosaminidase activity database_cross_reference “Reactome:R-HSA-9638076”
- label “HEXB cleaves the terminal GlcNAc from small HA fragments”

beta-alanine biosynthetic process `http://purl.obolibrary.org/obo/GO_0019483`

Added

beta-alanine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31510”^^anyURI
beta-alanine biosynthetic process narrowMatch PWY-3941
beta-alanine biosynthetic process narrowMatch PWY-5760
beta-alanine biosynthetic process narrowMatch PWY-3981
beta-alanine biosynthetic process database_cross_reference “MetaCyc:PWY-3981”
beta-alanine biosynthetic process database_cross_reference “MetaCyc:PWY-5760”
beta-alanine biosynthetic process database_cross_reference “MetaCyc:PWY-3941”
beta-alanine biosynthetic process narrowMatch PWY-3982
beta-alanine biosynthetic process database_cross_reference “MetaCyc:PWY-3982”
beta-alanine biosynthetic process database_cross_reference “MetaCyc:PWY-5155”
beta-alanine biosynthetic process narrowMatch PWY-5155

beta-alanine catabolic process `http://purl.obolibrary.org/obo/GO_0019484`

Removed

beta-alanine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins.”
- database_cross_reference “GOC:jl”
- database_cross_reference “ISBN:0198506732”

Added

beta-alanine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of beta-alanine.”
- database_cross_reference “GOC:curators”
beta-alanine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI

beta-alanine:pyruvate transaminase activity `http://purl.obolibrary.org/obo/GO_0016223`

Removed

beta-alanine:pyruvate transaminase activity definition “Catalysis of the reaction: L-alanine + 2-oxopropanoate = pyruvate + beta-alanine.”
- database_cross_reference “RHEA:14077”
beta-alanine:pyruvate transaminase activity SubClassOf transaminase activity

Added

beta-alanine:pyruvate transaminase activity definition “Catalysis of the reaction: L-alanine + 3-oxopropanoate = beta-alanine + pyruvate.”
- database_cross_reference “RHEA:14077”
beta-alanine:pyruvate transaminase activity SubClassOf amino acid transaminase activity

beta-alanyl-CoA ammonia-lyase activity `http://purl.obolibrary.org/obo/GO_0047698`

Removed

beta-alanyl-CoA ammonia-lyase activity definition “Catalysis of the reaction: beta-alanyl-CoA = acryloyl-CoA + NH3.”
- database_cross_reference “MetaCyc:BETA-ALANYL-COA-AMMONIA-LYASE-RXN”
- database_cross_reference “EC:4.3.1.6”

Added

beta-alanyl-CoA ammonia-lyase activity definition “Catalysis of the reaction: beta-alanyl-CoA = acryloyl-CoA + NH4+.”
- database_cross_reference “RHEA:12416”

beta-aspartyl-peptidase activity `http://purl.obolibrary.org/obo/GO_0008798`

Removed

beta-aspartyl-peptidase activity database_cross_reference “Reactome:R-HSA-5696365”
- label “ASRGL1 hydrolyses aspartame to L-Asp, L-Phe”

beta-galactosidase activity `http://purl.obolibrary.org/obo/GO_0004565`

Removed

beta-galactosidase activity comment “Note that the inclusion of ‘MetaCyc:BGALACT-PWY’ is exceptional: normally MetaCyc pathway entries are database references for biological process terms, not molecular function terms. An exception was made in this case because the MetaCyc entry ‘BGALACT-PWY’ describes only one reaction, that catalyzed by beta-galactosidase.”
beta-galactosidase activity database_cross_reference “Reactome:R-HSA-1793217”
- label “Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase”
beta-galactosidase activity relatedMatch BGALACT-PWY

Added

beta-galactosidase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI
beta-galactosidase activity database_cross_reference “Reactome:R-HSA-1793217”
- label “Unknown endo–galactosidase cleaves keratan chain”

beta-galactoside (CMP) alpha-2,3-sialyltransferase activity `http://purl.obolibrary.org/obo/GO_0003836`

Removed

beta-galactoside (CMP) alpha-2,3-sialyltransferase activity database_cross_reference “Reactome:R-HSA-981497”
- label “ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position”
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity database_cross_reference “Reactome:R-HSA-2046285”
- label “The keratan chain can be capped by N-acetylneuraminic acid”

Added

beta-galactoside (CMP) alpha-2,3-sialyltransferase activity database_cross_reference “RHEA:56204”
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity narrowMatch 56204
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity narrowMatch 56208
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity database_cross_reference “RHEA:56208”
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity database_cross_reference “Reactome:R-HSA-2046285”
- label “ST3GAL1-4,6 optionally cap keratan chain”

beta-galactoside alpha-2,6-sialyltransferase activity `http://purl.obolibrary.org/obo/GO_0003835`

Added

beta-glucuronidase activity `http://purl.obolibrary.org/obo/GO_0004566`

Removed

beta-glucuronidase activity database_cross_reference “Reactome:R-HSA-2162226”
- label “GUSB tetramer hydrolyses GlcA-1,3-GlcNAc”

Added

beta-glucuronidase activity narrowMatch 76111
beta-glucuronidase activity narrowMatch 30475
beta-glucuronidase activity database_cross_reference “RHEA:30475”
beta-glucuronidase activity database_cross_reference “Reactome:R-HSA-2162226”
- label “GUSB tetramer hydrolyzes GlcA-1,3-GlcNAc”
beta-glucuronidase activity narrowMatch 28326
beta-glucuronidase activity database_cross_reference “RHEA:76111”
beta-glucuronidase activity database_cross_reference “RHEA:28326”

beta-lactamase activity `http://purl.obolibrary.org/obo/GO_0008800`

Added

beta-lactamase activity database_cross_reference “Reactome:R-HSA-9911520”
- label “TEM-1 hydrolyzes penicillin G”
beta-lactamase activity database_cross_reference “Reactome:R-HSA-9911519”
- label “BlaSHV-12 hydrolyzes cephalothin”
beta-lactamase activity database_cross_reference “Reactome:R-HSA-9911513”
- label “BlaSHV-12 hydrolyzes ceftriaxone”
beta-lactamase activity database_cross_reference “Reactome:R-HSA-9911515”
- label “KPC-2 hydrolyzes cephalothin”
beta-lactamase activity database_cross_reference “Reactome:R-HSA-9911518”
- label “OXA-9 hydrolyzes penicillin G”

beta-ureidopropionase activity `http://purl.obolibrary.org/obo/GO_0003837`

Removed

beta-ureidopropionase activity definition “Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3.”
- database_cross_reference “EC:3.5.1.6”

Added

beta-ureidopropionase activity definition “Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH4+.”
- database_cross_reference “EC:3.5.1.6”

bicoid mRNA localization `http://purl.obolibrary.org/obo/GO_0045450`

Removed

bicoid mRNA localization definition “Any process in which bicoid mRNA is transported to and maintained within the oocyte as part of the specification of the anterior/posterior axis.”
- database_cross_reference “GOC:go_curators”

Added

bicoid mRNA localization definition “Any process in which bicoid mRNA is transported to and maintained within the oocyte as part of the specification of the anterior/posterior axis.”
- database_cross_reference “GOC:curators”

bifid shunt `http://purl.obolibrary.org/obo/GO_0019658`

Removed

bifid shunt label “glucose fermentation to lactate and acetate”
bifid shunt SubClassOf obsolete glucose catabolic process to lactate

Added

bifid shunt has_exact_synonym “glucose fermentation to lactate and acetate”
bifid shunt label “bifid shunt”
bifid shunt term tracker item “https://github.com/geneontology/go-ontology/issues/31217”^^anyURI
bifid shunt SubClassOf glucose catabolic process
bifid shunt SubClassOf lactate metabolic process
bifid shunt SubClassOf fermentation

bile acid and bile salt transport `http://purl.obolibrary.org/obo/GO_0015721`

Added

bile acid and bile salt transport database_cross_reference “Reactome:R-HSA-9958517”
- label “SLC-mediated bile acid transport”

bile acid binding `http://purl.obolibrary.org/obo/GO_0032052`

Added

bile acid binding database_cross_reference “Reactome:R-HSA-8873850”
- label “STARD5 binds DCA, LCA”

bile acid biosynthetic process `http://purl.obolibrary.org/obo/GO_0006699`

Removed

bile acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.”
- database_cross_reference “GOC:go_curators”

Added

bile acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.”
- database_cross_reference “GOC:curators”

bile acid catabolic process `http://purl.obolibrary.org/obo/GO_0030573`

Removed

bile acid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile.”
- database_cross_reference “GOC:go_curators”

Added

bile acid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile.”
- database_cross_reference “GOC:curators”

bile acid metabolic process `http://purl.obolibrary.org/obo/GO_0008206`

Removed

bile acid metabolic process definition “The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.”
- database_cross_reference “GOC:go_curators”

Added

bile acid metabolic process definition “The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.”
- database_cross_reference “GOC:curators”

bindosome complex `http://purl.obolibrary.org/obo/GO_7770042`

Added

bindosome complex term tracker item “https://github.com/geneontology/go-ontology/issues/31422”^^anyURI
bindosome complex created by “dragon-ai-agent”
bindosome complex creation date “2026-01-29T01:57:42Z”
bindosome complex id “GO:7770042”
bindosome complex label “bindosome complex”
bindosome complex has_obo_namespace “cellular_component”
bindosome complex definition “A membrane-associated protein complex found in archaea that consists of sugar binding proteins assembled via a type IV pilin-like assembly system. The complex is located at the cell surface and functions in sugar uptake by facilitating the interaction between solute binding proteins and ABC transporters. The complex forms high molecular mass structures (400-600 kDa) that are integrated within or closely associated with the S-layer.”
- database_cross_reference “PMID:21234771”
- database_cross_reference “PMID:38877064”
Class: bindosome complex
bindosome complex SubClassOf membrane protein complex

bioactive lipid receptor activity `http://purl.obolibrary.org/obo/GO_0045125`

Added

bioactive lipid receptor activity database_cross_reference “Reactome:R-HSA-400434”
- label “FFAR1 binds fatty acids”

biofilm formation `http://purl.obolibrary.org/obo/GO_0042710`

Added

biofilm formation database_cross_reference “Reactome:R-HSA-9931953”
- label “Biofilm formation”

biogenic amine catabolic process `http://purl.obolibrary.org/obo/GO_0042402`

Removed

biogenic amine catabolic process definition “The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

biogenic amine catabolic process definition “The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

biological process involved in interaction with host `http://purl.obolibrary.org/obo/GO_0051701`

Added

biological process involved in interaction with host database_cross_reference “Reactome:R-HSA-9640148”
- label “Infection with Enterobacteria”

biological process involved in symbiotic interaction `http://purl.obolibrary.org/obo/GO_0044403`

Added

biological process involved in symbiotic interaction database_cross_reference “Reactome:R-HSA-9839923”
- label “Dengue Virus Infection”

biotin carboxyl carrier protein biosynthetic process `http://purl.obolibrary.org/obo/GO_0042966`

Removed

biotin carboxyl carrier protein biosynthetic process definition “The chemical reactions and pathways resulting in the formation of the biotin carboxyl carrier protein, a subunit of acetyl-coenzyme A carboxylase.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:8102363”

Added

biotin carboxyl carrier protein biosynthetic process definition “The chemical reactions and pathways resulting in the formation of the biotin carboxyl carrier protein, a subunit of acetyl-coenzyme A carboxylase.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:8102363”

biotin–[biotin carboxyl-carrier protein] ligase activity `http://purl.obolibrary.org/obo/GO_0004077`

Added

biotin–[biotin carboxyl-carrier protein] ligase activity database_cross_reference “Reactome:R-HSA-2993814”
- label “HLCS biotinylates ACACA:Mn2+”
biotin–[biotin carboxyl-carrier protein] ligase activity database_cross_reference “Reactome:R-HSA-9035990”
- label “Defective HLCS does not biotinylate 6x(PCCA:PCCB)”
biotin–[biotin carboxyl-carrier protein] ligase activity database_cross_reference “Reactome:R-HSA-2993447”
- label “HLCS biotinylates 6x(PCCA:PCCB)”
biotin–[biotin carboxyl-carrier protein] ligase activity database_cross_reference “Reactome:R-HSA-9035987”
- label “Defective HLCS does not biotinylate 6xMCCC1:6xMCCC2”
biotin–[biotin carboxyl-carrier protein] ligase activity database_cross_reference “Reactome:R-HSA-4167511”
- label “HLCS biotinylates ACACB”
biotin–[biotin carboxyl-carrier protein] ligase activity database_cross_reference “Reactome:R-HSA-2993799”
- label “HLCS biotinylates 6xMCCC1:6xMCCC2”
biotin–[biotin carboxyl-carrier protein] ligase activity database_cross_reference “Reactome:R-HSA-3323184”
- label “Defective HLCS does not biotinylate ACACA:Mn2+”
biotin–[biotin carboxyl-carrier protein] ligase activity database_cross_reference “Reactome:R-HSA-2993802”
- label “HLCS biotinylates PC:Mn2+”
biotin–[biotin carboxyl-carrier protein] ligase activity database_cross_reference “Reactome:R-HSA-9035988”
- label “Defective HLCS does not biotinylate PC:Mn2+”

biotin-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0047707`

Removed

biotin-CoA ligase activity SubClassOf acid-thiol ligase activity

bis(monoacylglycero)phosphate synthase activity `http://purl.obolibrary.org/obo/GO_0160121`

Added

biuret amidohydrolase activity `http://purl.obolibrary.org/obo/GO_0018750`

Removed

biuret amidohydrolase activity definition “Catalysis of the reaction: biuret + H2O = urea + CO2 + NH3.”
- database_cross_reference “EC:3.5.1.84”

Added

biuret amidohydrolase activity definition “Catalysis of the reaction: biuret + H2O = urea-1-carboxylate + NH4+.”
- database_cross_reference “RHEA:17525”

blasticidin-S deaminase activity `http://purl.obolibrary.org/obo/GO_0047711`

Removed

blasticidin-S deaminase activity definition “Catalysis of the reaction: blasticidin S + H2O = deaminohydroxyblasticidin S + NH3.”
- database_cross_reference “EC:3.5.4.23”
- database_cross_reference “MetaCyc:BLASTICIDIN-S-DEAMINASE-RXN”

Added

blasticidin-S deaminase activity definition “Catalysis of the reaction: blasticidin S + H2O + H+ = deaminohydroxyblasticidin S + NH4+.”
- database_cross_reference “RHEA:10148”

blood microparticle `http://purl.obolibrary.org/obo/GO_0072562`

Removed

blood microparticle SubClassOf part of some obsolete extracellular space

Added

blood microparticle SubClassOf part of some extracellular region

branched-chain 2-oxo acid dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0003863`

Added

branched-chain-amino-acid:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0004084`

Removed

branched-chain-amino-acid:2-oxoglutarate transaminase activity label “branched-chain-amino-acid transaminase activity”
branched-chain-amino-acid:2-oxoglutarate transaminase activity SubClassOf transaminase activity

Added

branched-chain-amino-acid:2-oxoglutarate transaminase activity has_exact_synonym “branched-chain-amino-acid transaminase activity”
branched-chain-amino-acid:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
branched-chain-amino-acid:2-oxoglutarate transaminase activity label “branched-chain-amino-acid:2-oxoglutarate transaminase activity”
branched-chain-amino-acid:2-oxoglutarate transaminase activity SubClassOf amino acid transaminase activity

broad specificity oxidative DNA demethylase activity `http://purl.obolibrary.org/obo/GO_0035516`

Added

budding cell apical bud growth `http://purl.obolibrary.org/obo/GO_0007118`

Removed

budding cell apical bud growth definition “Growth at the tip of a bud, in a cell that reproduces by budding.”
- database_cross_reference “GOC:go_curators”

Added

budding cell apical bud growth definition “Growth at the tip of a bud, in a cell that reproduces by budding.”
- database_cross_reference “GOC:curators”

budding cell bud growth `http://purl.obolibrary.org/obo/GO_0007117`

Removed

budding cell bud growth definition “The process in which the bud portion of a cell that reproduces by budding irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.”
- database_cross_reference “GOC:go_curators”

Added

budding cell bud growth definition “The process in which the bud portion of a cell that reproduces by budding irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.”
- database_cross_reference “GOC:curators”

budding cell isotropic bud growth `http://purl.obolibrary.org/obo/GO_0007119`

Removed

budding cell isotropic bud growth definition “Unlocalized bud growth such that the entire surface of the bud expands evenly, in a cell that reproduces by budding.”
- database_cross_reference “GOC:go_curators”

Added

budding cell isotropic bud growth definition “Unlocalized bud growth such that the entire surface of the bud expands evenly, in a cell that reproduces by budding.”
- database_cross_reference “GOC:curators”

bursicon neuropeptide hormone complex `http://purl.obolibrary.org/obo/GO_0031395`

Removed

bursicon neuropeptide hormone complex SubClassOf protein-containing complex
bursicon neuropeptide hormone complex SubClassOf part of some extracellular region

Added

bursicon neuropeptide hormone complex SubClassOf extracellular protein-containing complex

cAMP deaminase activity `http://purl.obolibrary.org/obo/GO_0090612`

Removed

cAMP deaminase activity definition “Catalysis of the reaction: cyclic adenosine monophosphate + H2O = cyclic inosine monophosphate + NH3.”
- database_cross_reference “RHEA:22908”
- database_cross_reference “PMID:24074367”

Added

cAMP deaminase activity definition “Catalysis of the reaction: 3’,5’-cyclic AMP + H2O + H+ = 3’,5’-cyclic IMP + NH4+.”
- database_cross_reference “RHEA:22908”
- database_cross_reference “PMID:24074367”

cAMP metabolic process `http://purl.obolibrary.org/obo/GO_0046058`

Removed

cAMP metabolic process definition “The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3’,5’-cyclophosphate).”
- database_cross_reference “GOC:go_curators”

Added

cAMP metabolic process definition “The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3’,5’-cyclophosphate).”
- database_cross_reference “GOC:curators”

cAMP-dependent protein kinase activity `http://purl.obolibrary.org/obo/GO_0004691`

Removed

cAMP-dependent protein kinase activity database_cross_reference “Reactome:R-HSA-163773”
- label “Phosphorylation of PF2K-Pase by PKA catalytic subunit”

Added

cAMP-dependent protein kinase activity database_cross_reference “Reactome:R-HSA-163773”
- label “PKA tetramer:cAMP phosphorylates PF2K-Pase”

cAMP/PKA signal transduction `http://purl.obolibrary.org/obo/GO_0141156`

Added

cAMP/PKA signal transduction database_cross_reference “Reactome:R-HSA-163358”
- label “PKA-mediated phosphorylation of key metabolic factors”

cGMP catabolic process `http://purl.obolibrary.org/obo/GO_0046069`

Removed

cGMP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of cyclic GMP, guanosine 3’,5’-phosphate.”
- database_cross_reference “GOC:go_curators”

Added

cGMP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of cyclic GMP, guanosine 3’,5’-phosphate.”
- database_cross_reference “GOC:curators”

cGMP metabolic process `http://purl.obolibrary.org/obo/GO_0046068`

Removed

cGMP metabolic process definition “The chemical reactions and pathways involving cyclic GMP, guanosine 3’,5’-phosphate.”
- database_cross_reference “GOC:go_curators”

Added

cGMP metabolic process definition “The chemical reactions and pathways involving cyclic GMP, guanosine 3’,5’-phosphate.”
- database_cross_reference “GOC:curators”

cGMP-dependent protein kinase activity `http://purl.obolibrary.org/obo/GO_0004692`

Added

cGMP-dependent protein kinase activity database_cross_reference “Reactome:R-HSA-9920025”
- label “PKG phosphorylates NS5”

cadmium ion import into vacuole `http://purl.obolibrary.org/obo/GO_0036249`

Added

cadmium ion import into vacuole SubClassOf intercellular transport

caffeine oxidase activity `http://purl.obolibrary.org/obo/GO_0034875`

Added

caffeine oxidase activity database_cross_reference “RHEA:27902”
caffeine oxidase activity narrowMatch 27902

calcium channel inhibitor activity `http://purl.obolibrary.org/obo/GO_0019855`

Added

calcium channel inhibitor activity database_cross_reference “Reactome:R-HSA-400046”
- label “L-type Calcium Channels close in pancreatic beta cells”

calcium import into the mitochondrion `http://purl.obolibrary.org/obo/GO_0036444`

Added

calcium import into the mitochondrion SubClassOf intercellular transport

calcium ion import into vacuole `http://purl.obolibrary.org/obo/GO_0140146`

Added

calcium ion import into vacuole SubClassOf intercellular transport

calcium ion transmembrane transport `http://purl.obolibrary.org/obo/GO_0070588`

Added

calcium ion transmembrane transport database_cross_reference “Reactome:R-HSA-425561”
- label “Sodium/Calcium exchangers”

calcium,diacylglycerol-dependent serine/threonine kinase activity `http://purl.obolibrary.org/obo/GO_0004698`

Added

calcium,diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-2179413”
- label “Activated PKC-alpha activate MMP3”
calcium,diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-5229194”
- label “Depolymerization of lamin filaments after PKC-mediated phosphorylation”
calcium,diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9010681”
- label “PKC phosphorylates ROBO3.1”
calcium,diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-1433508”
- label “PKC alpha interacts with and phosphorylates KIT”
calcium,diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-5218823”
- label “PKC phosphorylates sphingosine kinase 1”
calcium,diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-5138432”
- label “DVL2 is phosphorylated by PKC”
calcium,diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-8934446”
- label “Activated PKC phosphorylates SHC1”
calcium,diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-450550”
- label “PKCalpha phosphorylates HuR”
calcium,diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-74615”
- label “PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP”

calcium-ion regulated exocytosis `http://purl.obolibrary.org/obo/GO_0017156`

Removed

calcium-ion regulated exocytosis definition “The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.”
- database_cross_reference “GOC:go_curators”

Added

calcium-ion regulated exocytosis definition “The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.”
- database_cross_reference “GOC:curators”

camera-type eye development `http://purl.obolibrary.org/obo/GO_0043010`

Removed

camera-type eye development definition “The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_sensu”

Added

camera-type eye development definition “The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_sensu”

cannabidiolate synthase activity `http://purl.obolibrary.org/obo/GO_0102779`

Removed

cannabidiolate synthase activity definition “Catalysis of the reaction: cannabigerolate + O2 = cannabidiolate + hydrogen peroxide.”
- database_cross_reference “GOC:pz”
- database_cross_reference “RHEA:34411”

Added

cannabidiolate synthase activity definition “Catalysis of the reaction: cannabigerolate + O2 = cannabidiolate + H2O2.”
- database_cross_reference “RHEA:34411”

capsule polysaccharide biosynthetic process `http://purl.obolibrary.org/obo/GO_0045227`

Removed

capsule polysaccharide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi.”
- database_cross_reference “GOC:go_curators”

Added

capsule polysaccharide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi.”
- database_cross_reference “GOC:curators”

carbamate kinase activity `http://purl.obolibrary.org/obo/GO_0008804`

Removed

carbamate kinase activity definition “Catalysis of the reaction: ATP + NH3 + CO2 = ADP + carbamoyl phosphate.”
- database_cross_reference “EC:2.7.2.2”

Added

carbamate kinase activity definition “Catalysis of the reaction: hydrogencarbonate + NH4+ + ATP = carbamoyl phosphate + ADP + H2O + H+.”
- database_cross_reference “RHEA:10152”

carbamoyl-phosphate synthase (ammonia) activity `http://purl.obolibrary.org/obo/GO_0004087`

Added

carbamoyl-phosphate synthase (ammonia) activity database_cross_reference “Reactome:R-HSA-9955543”
- label “CPS1 variants don’t synthesize carbamoyl phosphate”

carbohydrate kinase activity `http://purl.obolibrary.org/obo/GO_0019200`

Removed

carbohydrate kinase activity database_cross_reference “Reactome:R-HSA-8931653”
- label “POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1”

carbohydrate metabolic process `http://purl.obolibrary.org/obo/GO_0005975`

Removed

carbohydrate metabolic process database_cross_reference “Reactome:R-HSA-71387”
- label “Metabolism of carbohydrates”

carbon catabolite regulation of transcription `http://purl.obolibrary.org/obo/GO_0045990`

Removed

carbon catabolite regulation of transcription definition “A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources.”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:9618445”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:18359269”

Added

carbon catabolite regulation of transcription definition “A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:9618445”
- database_cross_reference “PMID:18359269”

carbon tetrachloride catabolic process `http://purl.obolibrary.org/obo/GO_0019382`

Removed

carbon tetrachloride catabolic process definition “The chemical reactions and pathways resulting in the breakdown of carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants.”
- database_cross_reference “GOC:go_curators”

Added

carbon tetrachloride catabolic process definition “The chemical reactions and pathways resulting in the breakdown of carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants.”
- database_cross_reference “GOC:curators”

carbon-nitrogen lyase activity `http://purl.obolibrary.org/obo/GO_0016840`

Removed

carbon-nitrogen lyase activity definition “Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99).”
- database_cross_reference “EC:4.3.-.-“

Added

carbon-nitrogen lyase activity definition “Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH4+, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99).”
- database_cross_reference “EC:4.3.-.-“

carbon-sulfur lyase activity `http://purl.obolibrary.org/obo/GO_0016846`

Added

carbon-sulfur lyase activity database_cross_reference “Reactome:R-HSA-1614591”
- label “Excess cysteine yields lanthionine and H2S”
carbon-sulfur lyase activity database_cross_reference “Reactome:R-HSA-1614614”
- label “Cysteine is degraded to pyruvate and H2S”

carbonyl reductase (NADPH) activity `http://purl.obolibrary.org/obo/GO_0004090`

Added

carbonyl reductase (NADPH) activity narrowMatch 64416
carbonyl reductase (NADPH) activity narrowMatch 32619
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:47540”
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:70219”
carbonyl reductase (NADPH) activity narrowMatch 62216
carbonyl reductase (NADPH) activity narrowMatch 16817
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:42500”
carbonyl reductase (NADPH) activity narrowMatch 62268
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:31891”
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:64416”
carbonyl reductase (NADPH) activity narrowMatch 70219
carbonyl reductase (NADPH) activity narrowMatch 81719
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:25960”
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:53820”
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:10724”
carbonyl reductase (NADPH) activity narrowMatch 45116
carbonyl reductase (NADPH) activity narrowMatch 16321
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:32339”
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:63476”
carbonyl reductase (NADPH) activity narrowMatch 25960
carbonyl reductase (NADPH) activity narrowMatch 35607
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:84223”
carbonyl reductase (NADPH) activity narrowMatch 10724
carbonyl reductase (NADPH) activity narrowMatch 31891
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:35607”
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:70215”
carbonyl reductase (NADPH) activity narrowMatch 47540
carbonyl reductase (NADPH) activity narrowMatch 13829
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:68144”
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:85047”
carbonyl reductase (NADPH) activity narrowMatch 32339
carbonyl reductase (NADPH) activity narrowMatch 62068
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:16321”
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:12212”
carbonyl reductase (NADPH) activity narrowMatch 84223
carbonyl reductase (NADPH) activity narrowMatch 63480
carbonyl reductase (NADPH) activity narrowMatch 36587
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:65060”
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:81575”
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:81583”
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:65496”
carbonyl reductase (NADPH) activity narrowMatch 68148
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:68140”
carbonyl reductase (NADPH) activity narrowMatch 42768
carbonyl reductase (NADPH) activity narrowMatch 85047
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:16817”
carbonyl reductase (NADPH) activity narrowMatch 68136
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:42768”
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:68136”
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:45116”
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:13829”
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:82231”
carbonyl reductase (NADPH) activity narrowMatch 74707
carbonyl reductase (NADPH) activity narrowMatch 70215
carbonyl reductase (NADPH) activity narrowMatch 65496
carbonyl reductase (NADPH) activity narrowMatch 81575
carbonyl reductase (NADPH) activity narrowMatch 42500
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:62216”
carbonyl reductase (NADPH) activity narrowMatch 53820
carbonyl reductase (NADPH) activity narrowMatch 63504
carbonyl reductase (NADPH) activity narrowMatch 63476
carbonyl reductase (NADPH) activity narrowMatch 85103
carbonyl reductase (NADPH) activity narrowMatch 65060
carbonyl reductase (NADPH) activity narrowMatch 81583
carbonyl reductase (NADPH) activity narrowMatch 68144
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:18941”
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:62068”
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:85103”
carbonyl reductase (NADPH) activity narrowMatch 18941
carbonyl reductase (NADPH) activity narrowMatch 12212
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:65056”
carbonyl reductase (NADPH) activity narrowMatch 68140
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:68148”
carbonyl reductase (NADPH) activity narrowMatch 82231
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:62268”
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:32619”
carbonyl reductase (NADPH) activity narrowMatch 65056
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:74707”
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:81719”
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:36587”
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:63504”
carbonyl reductase (NADPH) activity database_cross_reference “RHEA:63480”

carboxy-lyase activity `http://purl.obolibrary.org/obo/GO_0016831`

Added

carboxy-lyase activity database_cross_reference “Reactome:R-HSA-9856737”
- label “Unknown enzyme(s) process 4-HMA to 4-Hbz”

carboxylesterase activity `http://purl.obolibrary.org/obo/GO_0106435`

Added

carboxylesterase activity database_cross_reference “RHEA:31779”
carboxylesterase activity narrowMatch 38555
carboxylesterase activity narrowMatch 50148
carboxylesterase activity database_cross_reference “RHEA:63052”
carboxylesterase activity narrowMatch 63052
carboxylesterase activity database_cross_reference “RHEA:59388”
carboxylesterase activity database_cross_reference “RHEA:50148”
carboxylesterase activity narrowMatch 59388
carboxylesterase activity database_cross_reference “RHEA:38555”
carboxylesterase activity narrowMatch 31779

carboxylic acid metabolic process `http://purl.obolibrary.org/obo/GO_0019752`

Added

carboxylic acid metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31063”^^anyURI
carboxylic acid metabolic process in_subset gocheck_do_not_annotate

cardioblast cell fate commitment `http://purl.obolibrary.org/obo/GO_0042684`

Removed

cardioblast cell fate commitment definition “The process in which a cell becomes committed to becoming a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.”
- database_cross_reference “GOC:go_curators”

Added

cardioblast cell fate commitment definition “The process in which a cell becomes committed to becoming a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.”
- database_cross_reference “GOC:curators”

cardioblast cell fate determination `http://purl.obolibrary.org/obo/GO_0007510`

Removed

cardioblast cell fate determination definition “The cell fate determination process in which a cell becomes capable of differentiating autonomously into a cardioblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.”
- database_cross_reference “GOC:go_curators”

Added

cardioblast cell fate determination definition “The cell fate determination process in which a cell becomes capable of differentiating autonomously into a cardioblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.”
- database_cross_reference “GOC:curators”

cardioblast cell fate specification `http://purl.obolibrary.org/obo/GO_0042685`

Removed

cardioblast cell fate specification definition “The process in which a cell becomes capable of differentiating autonomously into a cardioblast cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.”
- database_cross_reference “GOC:go_curators”

Added

cardioblast cell fate specification definition “The process in which a cell becomes capable of differentiating autonomously into a cardioblast cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.”
- database_cross_reference “GOC:curators”

cardioblast differentiation `http://purl.obolibrary.org/obo/GO_0010002`

Removed

cardioblast differentiation definition “The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.”
- database_cross_reference “GOC:go_curators”

Added

cardioblast differentiation definition “The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.”
- database_cross_reference “GOC:curators”

cardiolipin biosynthetic process `http://purl.obolibrary.org/obo/GO_0032049`

Added

cardiolipin biosynthetic process narrowMatch PWY-5269
cardiolipin biosynthetic process narrowMatch PWY0-1545
cardiolipin biosynthetic process database_cross_reference “MetaCyc:PWY0-1545”
cardiolipin biosynthetic process narrowMatch PWY-5668
cardiolipin biosynthetic process database_cross_reference “MetaCyc:PWY-5668”
cardiolipin biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI

cardiolipin dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0160241`

Added

cardiolipin dehydrogenase (NAD+) activity narrowMatch 81095
cardiolipin dehydrogenase (NAD+) activity database_cross_reference “RHEA:81095”

cargo receptor activity `http://purl.obolibrary.org/obo/GO_0038024`

Added

cargo receptor activity database_cross_reference “Reactome:R-HSA-350186”
- label “CUBN binds GC:25(OH)D”
cargo receptor activity database_cross_reference “Reactome:R-HSA-2160915”
- label “Receptor-mediated uptake of HA”

carnitine 3-dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0047728`

Added

carnitine 3-dehydrogenase activity narrowMatch 25330
carnitine 3-dehydrogenase activity database_cross_reference “RHEA:25330”

carnitine O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0016406`

Added

carnitine O-acyltransferase activity database_cross_reference “Reactome:R-HSA-200410”
- label “CPT2 converts acylcarnitine to acyl-CoA”

carnitine O-palmitoyltransferase activity `http://purl.obolibrary.org/obo/GO_0004095`

Removed

carnitine O-palmitoyltransferase activity database_cross_reference “Reactome:R-HSA-200410”
- label “CPT2 converts palmitoyl carnitine to palmitoyl-CoA”

carnitine metabolic process, CoA-linked `http://purl.obolibrary.org/obo/GO_0019254`

Removed

carnitine metabolic process, CoA-linked definition “The chemical reactions and pathways involving carnitine, where metabolism is linked to CoA.”
- database_cross_reference “GOC:go_curators”

Added

carnitine metabolic process, CoA-linked definition “The chemical reactions and pathways involving carnitine, where metabolism is linked to CoA.”
- database_cross_reference “GOC:curators”

carnitine-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0051108`

Removed

carnitine-CoA ligase activity SubClassOf acid-amino acid ligase activity

carnitine:O-acyl-L-carnitine antiporter activity `http://purl.obolibrary.org/obo/GO_0005476`

Removed

carnitine:O-acyl-L-carnitine antiporter activity database_cross_reference “Reactome:R-HSA-200424”
- label “Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane”

Added

carnitine:O-acyl-L-carnitine antiporter activity database_cross_reference “Reactome:R-HSA-200424”
- label “Exchange of acylcarnitine and carnitine across the inner mitochondrial membrane”

carnosine biosynthetic process `http://purl.obolibrary.org/obo/GO_0035499`

Added

carnosine biosynthetic process database_cross_reference “MetaCyc:PWY66-420”
carnosine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31510”^^anyURI

carotene biosynthetic process `http://purl.obolibrary.org/obo/GO_0016120`

Removed

carotene biosynthetic process definition “The chemical reactions and pathways resulting in the formation of carotenes, hydrocarbon carotenoids.”
- database_cross_reference “GOC:go_curators”

Added

carotene biosynthetic process definition “The chemical reactions and pathways resulting in the formation of carotenes, hydrocarbon carotenoids.”
- database_cross_reference “GOC:curators”

carotene catabolic process `http://purl.obolibrary.org/obo/GO_0016121`

Removed

carotene catabolic process definition “The chemical reactions and pathways resulting in the breakdown of carotenes, hydrocarbon carotenoids.”
- database_cross_reference “GOC:go_curators”

Added

carotene catabolic process definition “The chemical reactions and pathways resulting in the breakdown of carotenes, hydrocarbon carotenoids.”
- database_cross_reference “GOC:curators”

carotenoid biosynthetic process `http://purl.obolibrary.org/obo/GO_0016117`

Removed

carotenoid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail.”
- database_cross_reference “GOC:go_curators”

Added

carotenoid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail.”
- database_cross_reference “GOC:curators”

carotenoid catabolic process `http://purl.obolibrary.org/obo/GO_0016118`

Removed

carotenoid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail.”
- database_cross_reference “GOC:go_curators”

Added

carotenoid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail.”
- database_cross_reference “GOC:curators”

carpel development `http://purl.obolibrary.org/obo/GO_0048440`

Removed

carpel development definition “The process whose specific outcome is the progression of the carpel over time, from its formation to the mature structure. A carpel is an organ (generally believed to be a modified foliar unit) at the centre of a flower, bearing one or more ovules and having its margins fused together or with other carpels to enclose the ovule in an ovary, and consisting also of a stigma and usually a style.”
- database_cross_reference “GOC:go_curators”

Added

carpel development definition “The process whose specific outcome is the progression of the carpel over time, from its formation to the mature structure. A carpel is an organ (generally believed to be a modified foliar unit) at the centre of a flower, bearing one or more ovules and having its margins fused together or with other carpels to enclose the ovule in an ovary, and consisting also of a stigma and usually a style.”
- database_cross_reference “GOC:curators”

carpel morphogenesis `http://purl.obolibrary.org/obo/GO_0048445`

Removed

carpel morphogenesis definition “The process in which the anatomical structures of the carpel are generated and organized.”
- database_cross_reference “GOC:go_curators”

Added

carpel morphogenesis definition “The process in which the anatomical structures of the carpel are generated and organized.”
- database_cross_reference “GOC:curators”

catalase activity `http://purl.obolibrary.org/obo/GO_0004096`

Removed

catalase activity definition “Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O.”
- database_cross_reference “EC:1.11.1.6”

Added

catalase activity definition “Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O.”
- database_cross_reference “EC:1.11.1.6”

catechol O-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0016206`

Added

catechol O-methyltransferase activity database_cross_reference “RHEA:72259”
catechol O-methyltransferase activity database_cross_reference “RHEA:72243”
catechol O-methyltransferase activity narrowMatch 72247
catechol O-methyltransferase activity database_cross_reference “RHEA:72247”
catechol O-methyltransferase activity narrowMatch 72259
catechol O-methyltransferase activity database_cross_reference “RHEA:72255”
catechol O-methyltransferase activity narrowMatch 73719
catechol O-methyltransferase activity database_cross_reference “RHEA:73719”
catechol O-methyltransferase activity narrowMatch 51268
catechol O-methyltransferase activity database_cross_reference “RHEA:72251”
catechol O-methyltransferase activity narrowMatch 72255
catechol O-methyltransferase activity narrowMatch 72251
catechol O-methyltransferase activity database_cross_reference “RHEA:51268”
catechol O-methyltransferase activity narrowMatch 72243

catechol catabolic process, meta-cleavage `http://purl.obolibrary.org/obo/GO_0019616`

Added

catechol catabolic process, meta-cleavage narrowMatch PWY-5415
catechol catabolic process, meta-cleavage database_cross_reference “MetaCyc:PWY-5419”
catechol catabolic process, meta-cleavage database_cross_reference “MetaCyc:PWY-5420”
catechol catabolic process, meta-cleavage term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
catechol catabolic process, meta-cleavage narrowMatch P183-PWY
catechol catabolic process, meta-cleavage narrowMatch PWY-5419
catechol catabolic process, meta-cleavage narrowMatch PWY-5420
catechol catabolic process, meta-cleavage database_cross_reference “MetaCyc:PWY-5415”

catechol catabolic process, ortho-cleavage `http://purl.obolibrary.org/obo/GO_0019615`

Added

catechol catabolic process, ortho-cleavage narrowMatch CATECHOL-ORTHO-CLEAVAGE-PWY
catechol catabolic process, ortho-cleavage narrowMatch PWY-5417
catechol catabolic process, ortho-cleavage term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
catechol catabolic process, ortho-cleavage database_cross_reference “MetaCyc:PWY-5417”

catechol oxidase activity `http://purl.obolibrary.org/obo/GO_0004097`

Added

catechol oxidase activity database_cross_reference “Reactome:R-HSA-8878581”
- label “TYRP1 oxidises DHICA to IQCA”
catechol oxidase activity database_cross_reference “Reactome:R-HSA-5663050”
- label “DHI and DHICA polymerize forming eumelanin”
catechol oxidase activity database_cross_reference “Reactome:R-HSA-5662662”
- label “Tyrosinase oxidises tyrosine to dopaquinone”
catechol oxidase activity database_cross_reference “Reactome:R-HSA-5662692”
- label “Dopa is oxidized to dopaquinone by TYR”

catechol-containing compound biosynthetic process `http://purl.obolibrary.org/obo/GO_0009713`

Removed

catechol-containing compound biosynthetic process definition “The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent.”
- database_cross_reference “GOC:go_curators”

Added

catechol-containing compound biosynthetic process definition “The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent.”
- database_cross_reference “GOC:curators”

catechol-containing compound catabolic process `http://purl.obolibrary.org/obo/GO_0019614`

Removed

catechol-containing compound catabolic process definition “The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent.”
- database_cross_reference “GOC:go_curators”

Added

catechol-containing compound catabolic process definition “The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent.”
- database_cross_reference “GOC:curators”

cell body `http://purl.obolibrary.org/obo/GO_0044297`

Removed

cell body definition “The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.”
- database_cross_reference “GOC:go_curators”

Added

cell body definition “The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.”
- database_cross_reference “GOC:curators”

cell cycle `http://purl.obolibrary.org/obo/GO_0007049`

Removed

cell cycle definition “The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_cell_cycle”

Added

cell cycle definition “The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_cell_cycle”

cell development `http://purl.obolibrary.org/obo/GO_0048468`

Removed

cell development definition “The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place.”
- database_cross_reference “GOC:go_curators”

Added

cell development definition “The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place.”
- database_cross_reference “GOC:curators”

cell division `http://purl.obolibrary.org/obo/GO_0051301`

Removed

cell division definition “The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:di”
- database_cross_reference “GOC:pr”

Added

cell division definition “The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:di”
- database_cross_reference “GOC:pr”

cell fate specification `http://purl.obolibrary.org/obo/GO_0001708`

Removed

cell fate specification definition “The cellular developmental process involved in cell fate commitment in which the cell is designated to follow a developmental path, unless they receive extrinsic cues that direct an alternative fate.”
- database_cross_reference “GOC:go_curators”

Added

cell fate specification definition “The cellular developmental process involved in cell fate commitment in which the cell is designated to follow a developmental path, unless they receive extrinsic cues that direct an alternative fate.”
- database_cross_reference “GOC:curators”

cell maturation `http://purl.obolibrary.org/obo/GO_0048469`

Removed

cell maturation definition “The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state.”
- database_cross_reference “GOC:go_curators”

Added

cell maturation definition “The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state.”
- database_cross_reference “GOC:curators”

cell morphogenesis `http://purl.obolibrary.org/obo/GO_0000902`

Removed

cell morphogenesis definition “The developmental process in which the size or shape of a cell is generated and organized.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:clt”

Added

cell morphogenesis definition “The developmental process in which the size or shape of a cell is generated and organized.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:clt”

cell outer membrane `http://purl.obolibrary.org/obo/GO_0009279`

Removed

cell outer membrane SubClassOf part of some external encapsulating structure

Added

cell outer membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31720”^^anyURI
cell outer membrane SubClassOf external encapsulating structure

cell recognition `http://purl.obolibrary.org/obo/GO_0008037`

Removed

cell recognition definition “The process in which a cell in an organism interprets its surroundings.”
- database_cross_reference “GOC:go_curators”

Added

cell recognition definition “The process in which a cell in an organism interprets its surroundings.”
- database_cross_reference “GOC:curators”

cell volume homeostasis `http://purl.obolibrary.org/obo/GO_0006884`

Removed

cell volume homeostasis definition “Any process involved in maintaining the steady state of a cell’s volume. The cell’s volume refers to the three-dimensional space occupied by a cell.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

cell volume homeostasis definition “Any process involved in maintaining the steady state of a cell’s volume. The cell’s volume refers to the three-dimensional space occupied by a cell.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

cell wall macromolecule biosynthetic process `http://purl.obolibrary.org/obo/GO_0044038`

Removed

cell wall macromolecule biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a macromolecule destined to form part of a cell wall.”
- database_cross_reference “GOC:go_curators”

Added

cell wall macromolecule biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a macromolecule destined to form part of a cell wall.”
- database_cross_reference “GOC:curators”

cell wall macromolecule catabolic process `http://purl.obolibrary.org/obo/GO_0016998`

Removed

cell wall macromolecule catabolic process definition “The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall.”
- database_cross_reference “GOC:go_curators”

Added

cell wall macromolecule catabolic process definition “The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall.”
- database_cross_reference “GOC:curators”

cell-cell fusion `http://purl.obolibrary.org/obo/GO_0140253`

Removed

cell-cell fusion SubClassOf has part some obsolete plasma membrane fusion

Added

cell-cell fusion has_exact_synonym “plasma membrane fusion”

cell-cell signaling involved in cell fate commitment `http://purl.obolibrary.org/obo/GO_0045168`

Removed

cell-cell signaling involved in cell fate commitment definition “Signaling at long or short range between cells that results in the commitment of a cell to a certain fate.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

cell-cell signaling involved in cell fate commitment definition “Signaling at long or short range between cells that results in the commitment of a cell to a certain fate.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

cellobiose dehydrogenase (acceptor) activity `http://purl.obolibrary.org/obo/GO_0047735`

Added

cellular process `http://purl.obolibrary.org/obo/GO_0009987`

Removed

cellular process definition “Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.”
- database_cross_reference “GOC:isa_complete”
- database_cross_reference “GOC:go_curators”

Added

cellular process definition “Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:isa_complete”

cellular response to acid chemical `http://purl.obolibrary.org/obo/GO_0071229`

Removed

cellular response to acid chemical definition “Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “Wikipedia:Acid”

Added

cellular response to acid chemical definition “Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:curators”
- database_cross_reference “Wikipedia:Acid”

cellular response to acidic pH `http://purl.obolibrary.org/obo/GO_0071468`

Removed

cellular response to acidic pH definition “Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “Wikipedia:PH”

Added

cellular response to acidic pH definition “Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:curators”
- database_cross_reference “Wikipedia:PH”

cellular response to alkaline pH `http://purl.obolibrary.org/obo/GO_0071469`

Removed

cellular response to alkaline pH definition “Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “Wikipedia:PH”

Added

cellular response to alkaline pH definition “Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:curators”
- database_cross_reference “Wikipedia:PH”

cellular response to water deprivation `http://purl.obolibrary.org/obo/GO_0042631`

Removed

cellular response to water deprivation definition “Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of water.”
- database_cross_reference “GOC:go_curators”

Added

cellular response to water deprivation definition “Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of water.”
- database_cross_reference “GOC:curators”

cellular stress response to acid chemical `http://purl.obolibrary.org/obo/GO_0097533`

Removed

cellular stress response to acid chemical definition “Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:aa”
- database_cross_reference “PMID:10615049”
- database_cross_reference “GOC:rl”
- database_cross_reference “Wikipedia:Acid”
- database_cross_reference “GOC:BHF”
- database_cross_reference “PMID:19170886”

Added

cellular stress response to acid chemical definition “Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:aa”
- database_cross_reference “PMID:10615049”
- database_cross_reference “GOC:rl”
- database_cross_reference “Wikipedia:Acid”
- database_cross_reference “GOC:BHF”
- database_cross_reference “PMID:19170886”

cellular stress response to acidic pH `http://purl.obolibrary.org/obo/GO_1990451`

Removed

cellular stress response to acidic pH definition “Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in the homeostasis of organismal or cellular pH (with pH < 7). pH is a measure of the acidity or basicity of an aqueous solution.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:10615049”
- database_cross_reference “GOC:rl”
- database_cross_reference “GOC:BHF”

Added

cellular stress response to acidic pH definition “Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in the homeostasis of organismal or cellular pH (with pH < 7). pH is a measure of the acidity or basicity of an aqueous solution.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:10615049”
- database_cross_reference “GOC:rl”
- database_cross_reference “GOC:BHF”

cellularization `http://purl.obolibrary.org/obo/GO_0007349`

Removed

cellularization definition “The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_sensu”
- database_cross_reference “ISBN:0716731363”

Added

cellularization definition “The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_sensu”
- database_cross_reference “ISBN:0716731363”

cellulose synthase (UDP-forming) activity `http://purl.obolibrary.org/obo/GO_0016760`

Added

cellulose synthase (UDP-forming) activity database_cross_reference “RHEA:63060”
cellulose synthase (UDP-forming) activity database_cross_reference “Reactome:R-HSA-9932210”
- label “Bcs complex synthesizes cellulose from UDP-Glc”
cellulose synthase (UDP-forming) activity narrowMatch 63060

centriole scaffold activity `http://purl.obolibrary.org/obo/GO_0140180`

Removed

centriole scaffold activity SubClassOf protein-macromolecule adaptor activity

Added

centriole scaffold activity term tracker item “https://github.com/geneontology/go-ontology/issues/31499”^^anyURI
centriole scaffold activity SubClassOf protein complex scaffold activity

cephalosporin-C:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0047740`

Removed

cephalosporin-C:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: (7R)-7-(5-carboxylato-5-oxopentanamido)deacetylcephalosporanate + D-glutamate = 2-oxoglutarate + cephalosporin C.”
- database_cross_reference “EC:2.6.1.74”
- database_cross_reference “RHEA:14553”
cephalosporin-C:2-oxoglutarate transaminase activity label “cephalosporin-C transaminase activity”

Added

cephalosporin-C:2-oxoglutarate transaminase activity label “cephalosporin-C:2-oxoglutarate transaminase activity”
cephalosporin-C:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: (7R)-7-(5-carboxylato-5-oxopentanamido)deacetylcephalosporanate + D-glutamate = 2-oxoglutarate + cephalosporin C.”
- database_cross_reference “RHEA:14553”
cephalosporin-C:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
cephalosporin-C:2-oxoglutarate transaminase activity has_exact_synonym “cephalosporin-C transaminase activity”

ceramide kinase activity `http://purl.obolibrary.org/obo/GO_0001729`

Added

ceramide kinase activity database_cross_reference “RHEA:46340”
ceramide kinase activity database_cross_reference “RHEA:43312”
ceramide kinase activity narrowMatch 46340
ceramide kinase activity narrowMatch 43312
ceramide kinase activity narrowMatch 47904
ceramide kinase activity database_cross_reference “RHEA:47904”

ceramide transfer activity `http://purl.obolibrary.org/obo/GO_0120017`

Added

ceramide transfer activity database_cross_reference “Reactome:R-HSA-9956909”
- label “CERT1-2 transfers CERA from the ER membrane to the Golgi membrane”

ceramide-1-phosphate phosphatase activity `http://purl.obolibrary.org/obo/GO_0106235`

Added

ceramide-1-phosphate phosphatase activity narrowMatch 33743
ceramide-1-phosphate phosphatase activity database_cross_reference “RHEA:33743”

chaeta morphogenesis `http://purl.obolibrary.org/obo/GO_0008407`

Removed

chaeta morphogenesis definition “The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:cjm”
- database_cross_reference “FBbt:00005177”

Added

chaeta morphogenesis definition “The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:cjm”
- database_cross_reference “FBbt:00005177”

chalcone biosynthetic process `http://purl.obolibrary.org/obo/GO_0009715`

Removed

chalcone biosynthetic process definition “The chemical reactions and pathways resulting in the formation of chalcone, phenyl steryl ketone or its hydroxylated derivatives.”
- database_cross_reference “GOC:go_curators”

Added

chalcone biosynthetic process definition “The chemical reactions and pathways resulting in the formation of chalcone, phenyl steryl ketone or its hydroxylated derivatives.”
- database_cross_reference “GOC:curators”

channel activity `http://purl.obolibrary.org/obo/GO_0015267`

Added

channel activity database_cross_reference “Reactome:R-HSA-9857682”
- label “p-S373-GJA1:p-S-ITGA5:ITGB1 (p-S373-Connexin-43:p-S-Integrin alpha5:Integrin beta1) transports prostaglandin E2 (PGE2) from the cytosol to the extracellular region”
channel activity database_cross_reference “Reactome:R-HSA-9905999”
- label “Pannexin1 (PANX1) channel in a complex with P2RX7 transports ATP from the cytosol to the extracellular region”
channel activity database_cross_reference “Reactome:R-HSA-9857649”
- label “p-S373-GJA1:p-S-ITGA5:ITGB1 (p-S373-Connexin-43:p-S-Integrin alpha5:Integrin beta1) transports ATP from the cytosol to the extracellular region”

chemoattractant activity `http://purl.obolibrary.org/obo/GO_0042056`

Removed

chemoattractant activity definition “Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

chemoattractant activity definition “Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

chemosensory behavior `http://purl.obolibrary.org/obo/GO_0007635`

Removed

chemosensory behavior definition “Behavior that is dependent upon the sensation of chemicals.”
- database_cross_reference “GOC:go_curators”

Added

chemosensory behavior definition “Behavior that is dependent upon the sensation of chemicals.”
- database_cross_reference “GOC:curators”

chemotaxis to arachidonate `http://purl.obolibrary.org/obo/GO_0034670`

Removed

chemotaxis to arachidonate definition “The directed movement of a motile cell or organism in response to the presence of arachidonic acid.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:18202452”

Added

chemotaxis to arachidonate definition “The directed movement of a motile cell or organism in response to the presence of arachidonic acid.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:18202452”

chemotaxis to cAMP `http://purl.obolibrary.org/obo/GO_0043327`

Removed

chemotaxis to cAMP definition “The directed movement of a motile cell or organism in response to the presence of 3’,5’-cAMP.”
- database_cross_reference “GOC:go_curators”

Added

chemotaxis to cAMP definition “The directed movement of a motile cell or organism in response to the presence of 3’,5’-cAMP.”
- database_cross_reference “GOC:curators”

chemotaxis to folate `http://purl.obolibrary.org/obo/GO_0043326`

Removed

chemotaxis to folate definition “The directed movement of a motile cell or organism in response to the presence of folate.”
- database_cross_reference “GOC:go_curators”

Added

chemotaxis to folate definition “The directed movement of a motile cell or organism in response to the presence of folate.”
- database_cross_reference “GOC:curators”

chitin catabolic process `http://purl.obolibrary.org/obo/GO_0006032`

Added

chitin catabolic process database_cross_reference “MetaCyc:PWY-6855”
chitin catabolic process narrowMatch PWY-6855

chloride transmembrane transport `http://purl.obolibrary.org/obo/GO_1902476`

Added

chloride transmembrane transport database_cross_reference “Reactome:R-HSA-426117”
- label “Cation-coupled Chloride cotransporters”

chlorophyll a catabolic process `http://purl.obolibrary.org/obo/GO_0033310`

Added

chlorophyll a catabolic process database_cross_reference “MetaCyc:PWY-7164”
chlorophyll a catabolic process narrowMatch PWY-7164
chlorophyll a catabolic process database_cross_reference “MetaCyc:PWY-6927”
chlorophyll a catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
chlorophyll a catabolic process narrowMatch PWY-5098
chlorophyll a catabolic process narrowMatch PWY-6927

chlorophyll biosynthetic process `http://purl.obolibrary.org/obo/GO_0015995`

Added

chlorophyll biosynthetic process narrowMatch CHLOROPHYLL-SYN
chlorophyll biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI

chlorophyllase activity `http://purl.obolibrary.org/obo/GO_0047746`

Added

chlorophyllase activity database_cross_reference “RHEA:38011”
chlorophyllase activity narrowMatch 38011

cholate-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0047747`

Removed

cholate-CoA ligase activity SubClassOf acid-thiol ligase activity

cholesterol 25-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0001567`

Added

cholesterol 25-hydroxylase activity database_cross_reference “RHEA:46132”
cholesterol 25-hydroxylase activity narrowMatch 46132

cholesterol O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0034736`

Added

cholesterol O-acyltransferase activity narrowMatch 64320
cholesterol O-acyltransferase activity database_cross_reference “RHEA:42796”
cholesterol O-acyltransferase activity narrowMatch 64328
cholesterol O-acyltransferase activity database_cross_reference “RHEA:64328”
cholesterol O-acyltransferase activity database_cross_reference “RHEA:64324”
cholesterol O-acyltransferase activity narrowMatch 42816
cholesterol O-acyltransferase activity narrowMatch 64324
cholesterol O-acyltransferase activity database_cross_reference “RHEA:46612”
cholesterol O-acyltransferase activity narrowMatch 42812
cholesterol O-acyltransferase activity narrowMatch 42796
cholesterol O-acyltransferase activity database_cross_reference “RHEA:42792”
cholesterol O-acyltransferase activity database_cross_reference “RHEA:64320”
cholesterol O-acyltransferase activity narrowMatch 46620
cholesterol O-acyltransferase activity database_cross_reference “RHEA:42812”
cholesterol O-acyltransferase activity database_cross_reference “RHEA:42816”
cholesterol O-acyltransferase activity narrowMatch 46612
cholesterol O-acyltransferase activity narrowMatch 41436
cholesterol O-acyltransferase activity database_cross_reference “RHEA:41436”
cholesterol O-acyltransferase activity narrowMatch 42792
cholesterol O-acyltransferase activity database_cross_reference “RHEA:46620”

cholesterol biosynthetic process via desmosterol `http://purl.obolibrary.org/obo/GO_0033489`

Removed

cholesterol biosynthetic process via desmosterol database_cross_reference “Reactome:R-HSA-6807047”
- label “Cholesterol biosynthesis via desmosterol”

cholesterol biosynthetic process via lathosterol `http://purl.obolibrary.org/obo/GO_0033490`

Removed

cholesterol biosynthetic process via lathosterol database_cross_reference “Reactome:R-HSA-6807062”
- label “Cholesterol biosynthesis via lathosterol”

cholesterol homeostasis `http://purl.obolibrary.org/obo/GO_0042632`

Removed

cholesterol homeostasis definition “Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.”
- database_cross_reference “GOC:go_curators”

Added

cholesterol homeostasis definition “Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.”
- database_cross_reference “GOC:curators”

choline catabolic process `http://purl.obolibrary.org/obo/GO_0042426`

Added

choline catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI
choline catabolic process database_cross_reference “MetaCyc:PWY-7167”
choline catabolic process narrowMatch PWY-7167

choline dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0008812`

Added

choline dehydrogenase activity database_cross_reference “RHEA:33051”
choline dehydrogenase activity narrowMatch 33051

choline trimethylamine lyase activity `http://purl.obolibrary.org/obo/GO_0120525`

Removed

choline trimethylamine lyase activity comment “Note that this term has a MetaCyc pathway reference as the pathway only has a single step.”
choline trimethylamine lyase activity relatedMatch PWY-7167

Added

choline trimethylamine lyase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI

choline:oxygen 1-oxidoreductase activity `http://purl.obolibrary.org/obo/GO_0033713`

Removed

choline:oxygen 1-oxidoreductase activity definition “Catalysis of the reaction: choline + O2 = betaine aldehyde + hydrogen peroxide.”
- database_cross_reference “RHEA:13505”
- database_cross_reference “EC:1.1.3.17”

Added

choline:oxygen 1-oxidoreductase activity definition “Catalysis of the reaction: choline + O2 = betaine aldehyde + H2O2.”
- database_cross_reference “RHEA:13505”
- database_cross_reference “EC:1.1.3.17”

chondroitin 2-sulfotransferase activity `http://purl.obolibrary.org/obo/GO_0034482`

Added

chondroitin 2-sulfotransferase activity database_cross_reference “Reactome:R-HSA-9941305”
- label “UST transfers sulfate to (2-)GlcA-GalNAc-6-sulfate”

chondroitin 4-sulfotransferase activity `http://purl.obolibrary.org/obo/GO_0047756`

Removed

chondroitin 4-sulfotransferase activity database_cross_reference “Reactome:R-HSA-1971483”
- label “Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13”

Added

chondroitin 4-sulfotransferase activity database_cross_reference “Reactome:R-HSA-1971483”
- label “CHST11,12,13,9 transfer sulfate to (4-)GalNAc”

chondroitin sulfate proteoglycan biosynthetic process `http://purl.obolibrary.org/obo/GO_0050650`

Added

chondroitin sulfate proteoglycan biosynthetic process database_cross_reference “Reactome:R-HSA-2022870”
- label “CS-GAG biosynthesis”

chondroitin-glucuronate 5-epimerase activity `http://purl.obolibrary.org/obo/GO_0047757`

Removed

chondroitin-glucuronate 5-epimerase activity database_cross_reference “Reactome:R-HSA-2022052”
- label “Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS)”

Added

chondroitin-glucuronate 5-epimerase activity database_cross_reference “Reactome:R-HSA-2022052”
- label “DSE converts GlcA to IdoA”

chordate pharyngeal muscle development `http://purl.obolibrary.org/obo/GO_0043282`

Removed

chordate pharyngeal muscle development definition “The process whose specific outcome is the progression of the pharyngeal muscle over time, from its formation to the mature structure. A pharyngeal muscle is any muscle that forms part of the pharynx.”
- database_cross_reference “GOC:go_curators”

Added

chordate pharyngeal muscle development definition “The process whose specific outcome is the progression of the pharyngeal muscle over time, from its formation to the mature structure. A pharyngeal muscle is any muscle that forms part of the pharynx.”
- database_cross_reference “GOC:curators”

chorismate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009423`

Added

chorismate biosynthetic process narrowMatch ARO-PWY
chorismate biosynthetic process database_cross_reference “MetaCyc:PWY-6163”
chorismate biosynthetic process narrowMatch PWY-6165
chorismate biosynthetic process narrowMatch PWY-6163
chorismate biosynthetic process database_cross_reference “MetaCyc:PWY-6165”
chorismate biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI

circadian behavior `http://purl.obolibrary.org/obo/GO_0048512`

Removed

circadian behavior definition “The specific behavior of an organism that recurs with a regularity of approximately 24 hours.”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:pr”

Added

circadian behavior definition “The specific behavior of an organism that recurs with a regularity of approximately 24 hours.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:pr”

circadian rhythm `http://purl.obolibrary.org/obo/GO_0007623`

Removed

circadian rhythm definition “Any biological process in an organism that recurs with a regularity of approximately 24 hours.”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:go_curators”
circadian rhythm database_cross_reference “Reactome:R-HSA-400253”
- label “Circadian Clock”

Added

circadian rhythm definition “Any biological process in an organism that recurs with a regularity of approximately 24 hours.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:bf”
circadian rhythm database_cross_reference “Reactome:R-HSA-9909396”
- label “Circadian clock”

citrate-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0047779`

Removed

citrate-CoA ligase activity SubClassOf acid-thiol ligase activity

Added

citrate-CoA ligase activity SubClassOf CoA-ligase activity

citrullinase activity `http://purl.obolibrary.org/obo/GO_0047781`

Removed

citrullinase activity definition “Catalysis of the reaction: H2O + citrulline = NH3 + CO2 + L-ornithine.”
- database_cross_reference “MetaCyc:CITRULLINASE-RXN”
- database_cross_reference “EC:3.5.1.20”

Added

citrullinase activity definition “Catalysis of the reaction: L-citrulline + H2O + 2 H+ = L-ornithine + NH4+ + CO2.”
- database_cross_reference “RHEA:11940”

classical-complement-pathway C3/C5 convertase complex `http://purl.obolibrary.org/obo/GO_0005601`

Removed

classical-complement-pathway C3/C5 convertase complex SubClassOf part of some obsolete extracellular space

Added

classical-complement-pathway C3/C5 convertase complex SubClassOf extracellular protein-containing complex

clathrin-coated endocytic vesicle `http://purl.obolibrary.org/obo/GO_0045334`

Removed

clathrin-coated endocytic vesicle definition “A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance.”
- database_cross_reference “GOC:go_curators”

Added

clathrin-coated endocytic vesicle definition “A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance.”
- database_cross_reference “GOC:curators”

clathrin-coated phagocytic vesicle `http://purl.obolibrary.org/obo/GO_0045336`

Removed

clathrin-coated phagocytic vesicle definition “A clathrin-coated, membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

clathrin-coated phagocytic vesicle definition “A clathrin-coated, membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

co-transcriptional mRNA 3’-end processing, cleavage and polyadenylation pathway `http://purl.obolibrary.org/obo/GO_0180010`

Added

co-transcriptional mRNA 3’-end processing, cleavage and polyadenylation pathway database_cross_reference “Reactome:R-HSA-9770562”
- label “mRNA Polyadenylation”

cobalamin catabolic process `http://purl.obolibrary.org/obo/GO_0042366`

Removed

cobalamin catabolic process definition “The chemical reactions and pathways resulting in the breakdown of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.”
- database_cross_reference “GOC:go_curators”

Added

cobalamin catabolic process definition “The chemical reactions and pathways resulting in the breakdown of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.”
- database_cross_reference “GOC:curators”

cobalamin metabolic process `http://purl.obolibrary.org/obo/GO_0009235`

Removed

cobalamin metabolic process definition “The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.”
- database_cross_reference “GOC:go_curators”

Added

cobalamin metabolic process definition “The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.”
- database_cross_reference “GOC:curators”

coenzyme M biosynthetic process `http://purl.obolibrary.org/obo/GO_0019295`

Added

coenzyme M biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
coenzyme M biosynthetic process database_cross_reference “MetaCyc:PWY-6643”
coenzyme M biosynthetic process narrowMatch P261-PWY
coenzyme M biosynthetic process narrowMatch PWY-6643

collagen type VI trimer `http://purl.obolibrary.org/obo/GO_0005589`

Added

collagen type VI trimer SubClassOf extracellular protein-containing complex

collagen type VII trimer `http://purl.obolibrary.org/obo/GO_0005590`

Added

collagen type VII trimer SubClassOf extracellular protein-containing complex

collagen type VIII trimer `http://purl.obolibrary.org/obo/GO_0005591`

Removed

collagen type VIII trimer SubClassOf part of some obsolete hexagonal collagen network of basement membrane

Added

collagen type VIII trimer SubClassOf part of some hexagonal collagen network

collagen type XIX trimer `http://purl.obolibrary.org/obo/GO_1990318`

Added

collagen type XIX trimer SubClassOf extracellular protein-containing complex

collagen type XXVI trimer `http://purl.obolibrary.org/obo/GO_1990324`

Added

collagen type XXVI trimer SubClassOf extracellular protein-containing complex

collagen type XXVIII trimer `http://purl.obolibrary.org/obo/GO_1990326`

Added

collagen type XXVIII trimer SubClassOf extracellular protein-containing complex

complement component C1 complex `http://purl.obolibrary.org/obo/GO_0005602`

Removed

complement component C1 complex SubClassOf part of some extracellular region
complement component C1 complex SubClassOf protein-containing complex

Added

complement component C1 complex SubClassOf extracellular protein-containing complex

complement component C1q complex `http://purl.obolibrary.org/obo/GO_0062167`

Removed

complement component C1q complex SubClassOf protein-containing complex
complement component C1q complex SubClassOf part of some extracellular region

Added

complement component C1q complex SubClassOf extracellular protein-containing complex

complex of collagen trimers `http://purl.obolibrary.org/obo/GO_0098644`

Removed

complex of collagen trimers SubClassOf part of some extracellular matrix

Added

complex of collagen trimers term tracker item “https://github.com/geneontology/go-ontology/issues/31491”^^anyURI

compound eye photoreceptor cell differentiation `http://purl.obolibrary.org/obo/GO_0001751`

Removed

compound eye photoreceptor cell differentiation definition “The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell.”
- database_cross_reference “GOC:go_curators”

Added

compound eye photoreceptor cell differentiation definition “The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell.”
- database_cross_reference “GOC:curators”

contractile muscle fiber `http://purl.obolibrary.org/obo/GO_0043292`

Removed

contractile muscle fiber definition “Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0815316194”

Added

contractile muscle fiber definition “Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0815316194”

copper import into the mitochondrion `http://purl.obolibrary.org/obo/GO_0140636`

Added

copper import into the mitochondrion SubClassOf intercellular transport

copper ion export from vacuole `http://purl.obolibrary.org/obo/GO_0140145`

Added

copper ion export from vacuole SubClassOf intercellular transport

copper ion transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0005375`

Removed

copper ion transmembrane transporter activity database_cross_reference “Reactome:R-HSA-437300”
- label “SLC31A1 transports Cu2+ from extracellular region to cytosol”

Added

copper ion transmembrane transporter activity database_cross_reference “Reactome:R-HSA-437300”
- label “SLC31A1 transports Cu1+ from extracellular region to cytosol”

coreceptor activity `http://purl.obolibrary.org/obo/GO_0015026`

Removed

coreceptor activity definition “Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity.”
- database_cross_reference “GOC:go_curators”

Added

coreceptor activity definition “Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity.”
- database_cross_reference “GOC:curators”

corolla development `http://purl.obolibrary.org/obo/GO_0048465`

Removed

corolla development definition “The process whose specific outcome is the progression of the corolla over time, from its formation to the mature structure.”
- database_cross_reference “GOC:go_curators”

Added

corolla development definition “The process whose specific outcome is the progression of the corolla over time, from its formation to the mature structure.”
- database_cross_reference “GOC:curators”

corticotropin-releasing hormone secretion `http://purl.obolibrary.org/obo/GO_0043396`

Removed

corticotropin-releasing hormone secretion definition “The regulated release of corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. CRH is produced by the hypothalamus and stimulates corticotropic cells of the anterior lobe of the pituitary to produce corticotropic hormone (CTH) and other biologically active substances e.g. 2-endorphin, release of CRH is affected by serum levels of cortisol, by stress and by the sleep/wake cycle.”
- database_cross_reference “PMID:11027914”
- database_cross_reference “GOC:go_curators”

Added

corticotropin-releasing hormone secretion definition “The regulated release of corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. CRH is produced by the hypothalamus and stimulates corticotropic cells of the anterior lobe of the pituitary to produce corticotropic hormone (CTH) and other biologically active substances e.g. 2-endorphin, release of CRH is affected by serum levels of cortisol, by stress and by the sleep/wake cycle.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:11027914”

creatine kinase activity `http://purl.obolibrary.org/obo/GO_0004111`

Removed

creatine kinase activity relatedMatch PWY-6158
creatine kinase activity comment “Note that this term has a MetaCyc pathway reference as the pathway only has a single step.”

Added

creatine kinase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI

creatinine catabolic process to formate `http://purl.obolibrary.org/obo/GO_0019621`

Removed

creatinine catabolic process to formate definition “The chemical reactions and pathways resulting in the breakdown of creatinine into other compounds, including formate.”
- database_cross_reference “GOC:go_curators”

Added

creatinine catabolic process to formate definition “The chemical reactions and pathways resulting in the breakdown of creatinine into other compounds, including formate.”
- database_cross_reference “GOC:curators”

creatinine deaminase activity `http://purl.obolibrary.org/obo/GO_0047790`

Removed

creatinine deaminase activity definition “Catalysis of the reaction: creatinine + H2O = N-methylhydantoin + NH3.”
- database_cross_reference “MetaCyc:CREATININE-DEAMINASE-RXN”
- database_cross_reference “EC:3.5.4.21”

Added

creatinine deaminase activity definition “Catalysis of the reaction: creatinine + H2O + H+ = N-methylhydantoin + NH4+.”
- database_cross_reference “RHEA:12681”

crotonobetaine-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0051109`

Removed

crotonobetaine-CoA ligase activity exactMatch 30079
crotonobetaine-CoA ligase activity definition “Catalysis of the reaction: CoA + crotono-betaine + ATP = AMP + diphosphate + crotonobetainyl-CoA.”
- database_cross_reference “MetaCyc:CROTCOALIG-RXN”

Added

crotonobetaine-CoA ligase activity narrowMatch 30079
crotonobetaine-CoA ligase activity narrowMatch 55960
crotonobetaine-CoA ligase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31616”^^anyURI
crotonobetaine-CoA ligase activity database_cross_reference “RHEA:28514”
crotonobetaine-CoA ligase activity narrowMatch 28514
crotonobetaine-CoA ligase activity definition “Catalysis of the reaction: (R)-carnitine + ATP + CoA = (R)-carnitinyl-CoA + AMP + diphosphate. Also catalyzes the transfer of CoA to crotonobetaine and gamma-butyrobetaine.”
- database_cross_reference “EC:6.2.1.48”
crotonobetaine-CoA ligase activity database_cross_reference “EC:6.2.1.48”
crotonobetaine-CoA ligase activity database_cross_reference “RHEA:55960”
crotonobetaine-CoA ligase activity exactMatch 6.2.1.48

curli secretion complex `http://purl.obolibrary.org/obo/GO_0062155`

Added

curli secretion complex SubClassOf extracellular protein-containing complex

cyanoalanine nitrilase activity `http://purl.obolibrary.org/obo/GO_0047427`

Added

cyanoalanine nitrilase activity database_cross_reference “RHEA:47936”
cyanoalanine nitrilase activity narrowMatch 47936

cyclic nucleotide biosynthetic process `http://purl.obolibrary.org/obo/GO_0009190`

Removed

cyclic nucleotide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

cyclic nucleotide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

cyclic nucleotide catabolic process `http://purl.obolibrary.org/obo/GO_0009214`

Removed

cyclic nucleotide catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

cyclic nucleotide catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

cyclic nucleotide metabolic process `http://purl.obolibrary.org/obo/GO_0009187`

Removed

cyclic nucleotide metabolic process definition “The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

cyclic nucleotide metabolic process definition “The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

cyclin-dependent protein serine/threonine kinase activity `http://purl.obolibrary.org/obo/GO_0004693`

Removed

cyclin-dependent protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-69756”
- label “Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes”
cyclin-dependent protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-69754”
- label “Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes”
cyclin-dependent protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-4086410”
- label “CDK1 phosphorylates BORA”

Added

cyclin-dependent protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9929904”
- label “CCNA:CDK1 phosphorylates MIS18BP1”
cyclin-dependent protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9929720”
- label “CCNA:CDK1 phosphorylates OBI1”
cyclin-dependent protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9929532”
- label “CCNA:CDK1 phosphorylates BORA”
cyclin-dependent protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9929482”
- label “CDK4:CCND1 phosphorylates SPOP”
cyclin-dependent protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9929514”
- label “CDK1 phosphorylates CCNA”
cyclin-dependent protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9929535”
- label “CCNA:CDK1 phosphorylates WEE1”
cyclin-dependent protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9929719”
- label “CCNA:CDK1 phosphorylates TICRR”
cyclin-dependent protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9929884”
- label “CCNA:CDK1 phosphorylates HJURP”
cyclin-dependent protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-4086410”
- label “CCNB:CDK1 phosphorylates BORA”
cyclin-dependent protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9929721”
- label “CCNA:CDK1 phosphorylates SGO1”
cyclin-dependent protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9929935”
- label “CCNA:CDK1 phosphorylates CDC25B”
cyclin-dependent protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9929717”
- label “CCNA:CDK1 phosphorylates FZR1”

cyclohexane-1-carboxylate catabolic process `http://purl.obolibrary.org/obo/GO_0010129`

Removed

cyclohexane-1-carboxylate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of cyclohexane-1-carboxylate, a alicyclic acid, in the absence of oxygen.”
- database_cross_reference “GOC:pz”
cyclohexane-1-carboxylate catabolic process label “anaerobic cyclohexane-1-carboxylate catabolic process”

Added

cyclohexane-1-carboxylate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of cyclohexane-1-carboxylate, an alicyclic acid.”
- database_cross_reference “GOC:pz”
cyclohexane-1-carboxylate catabolic process database_cross_reference “MetaCyc:PWY-8485”
cyclohexane-1-carboxylate catabolic process narrowMatch PWY-8486
cyclohexane-1-carboxylate catabolic process narrowMatch PWY-8485
cyclohexane-1-carboxylate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
cyclohexane-1-carboxylate catabolic process narrowMatch PWY-301
cyclohexane-1-carboxylate catabolic process database_cross_reference “MetaCyc:PWY-8486”
cyclohexane-1-carboxylate catabolic process label “cyclohexane-1-carboxylate catabolic process”
cyclohexane-1-carboxylate catabolic process SubClassOf monocarboxylic acid catabolic process

cyclohexanone dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0047797`

Added

cyclohexanone dehydrogenase activity narrowMatch 80151
cyclohexanone dehydrogenase activity database_cross_reference “RHEA:80151”

cyclohexylamine oxidase activity `http://purl.obolibrary.org/obo/GO_0018527`

Removed

cyclohexylamine oxidase activity definition “Catalysis of the reaction: cyclohexylamine + O2 + H2O = cyclohexanone + NH3 + hydrogen peroxide.”
- database_cross_reference “RHEA:18433”
- database_cross_reference “PMID:18451”

Added

cyclohexylamine oxidase activity definition “Catalysis of the reaction: cyclohexylamine + O2 + H2O = cyclohexanone + H2O2 + NH4+.”
- database_cross_reference “RHEA:18433”
- database_cross_reference “PMID:18451”

cysteine-S-conjugate beta-lyase activity `http://purl.obolibrary.org/obo/GO_0047804`

Added

cysteine-S-conjugate beta-lyase activity narrowMatch 22424
cysteine-S-conjugate beta-lyase activity database_cross_reference “RHEA:22424”
cysteine-S-conjugate beta-lyase activity narrowMatch 64744
cysteine-S-conjugate beta-lyase activity database_cross_reference “RHEA:64740”
cysteine-S-conjugate beta-lyase activity narrowMatch 64752
cysteine-S-conjugate beta-lyase activity database_cross_reference “RHEA:64748”
cysteine-S-conjugate beta-lyase activity narrowMatch 64740
cysteine-S-conjugate beta-lyase activity narrowMatch 13965
cysteine-S-conjugate beta-lyase activity narrowMatch 64748
cysteine-S-conjugate beta-lyase activity narrowMatch 64756
cysteine-S-conjugate beta-lyase activity database_cross_reference “RHEA:64744”
cysteine-S-conjugate beta-lyase activity database_cross_reference “RHEA:64752”
cysteine-S-conjugate beta-lyase activity database_cross_reference “RHEA:13965”
cysteine-S-conjugate beta-lyase activity database_cross_reference “RHEA:64756”

cysteine-conjugate:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0047802`

Removed

cysteine-conjugate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + S-(4-bromophenyl)-L-cysteine = (4-bromophenylsulfanyl)pyruvate + L-glutamate.”
- database_cross_reference “RHEA:13485”
- database_cross_reference “EC:2.6.1.75”
cysteine-conjugate:2-oxoglutarate transaminase activity label “cysteine-conjugate transaminase activity”

Added

cysteine-conjugate:2-oxoglutarate transaminase activity has_exact_synonym “cysteine-conjugate transaminase activity”
cysteine-conjugate:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
cysteine-conjugate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + S-(4-bromophenyl)-L-cysteine = (4-bromophenylsulfanyl)pyruvate + L-glutamate.”
- database_cross_reference “RHEA:13485”
cysteine-conjugate:2-oxoglutarate transaminase activity label “cysteine-conjugate:2-oxoglutarate transaminase activity”

cysteine-type endopeptidase activity `http://purl.obolibrary.org/obo/GO_0004197`

Removed

cysteine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-350158”
- label “LGMN degrades GC”
cysteine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9710101”
- label “CASP4, CASP5 cleave GSDMD”

Added

cysteine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-6800797”
- label “The PIDDosome activates CASP2”
cysteine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9947908”
- label “CASP4 autocatalysis on the bacterial surface”
cysteine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9792568”
- label “CTSL1 cleaves proHPSE”
cysteine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9947987”
- label “CASP4 cleaves IL18 at D36”
cysteine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9960522”
- label “CASP5 cleaves IL1B at D27”
cysteine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9947978”
- label “CASP5 cleaves IL18 at D36”
cysteine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9948146”
- label “CASP4 cleaves GSDMD”
cysteine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9958657”
- label “CASP4 cleaves IL1B at D27”
cysteine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9947861”
- label “CASP4 autocatalysis on LPS micelles”
cysteine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9947997”
- label “CASP5 cleaves GSDMD”
cysteine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-350158”
- label “LGMN hydrolyzes GC, releasing CUBN and 25(OH)D”
cysteine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9947849”
- label “CASP5 autocatalysis on LPS micelles”
cysteine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9960526”
- label “CASP4 cleaves IL1B at D116”
cysteine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9956714”
- label “CASP1 cleaves GBP1”

cysteine-type peptidase activity `http://purl.obolibrary.org/obo/GO_0008234`

Removed

cysteine-type peptidase activity database_cross_reference “Reactome:R-HSA-2022381”
- label “Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)”

Added

cysteine-type peptidase activity database_cross_reference “Reactome:R-HSA-2022381”
- label “Cathepsin Z (Cathepsin X) hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))”

cytidine metabolic process `http://purl.obolibrary.org/obo/GO_0046087`

Removed

cytidine metabolic process definition “The chemical reactions and pathways involving cytidine, cytosine riboside, a widely distributed nucleoside.”
- database_cross_reference “GOC:go_curators”

Added

cytidine metabolic process definition “The chemical reactions and pathways involving cytidine, cytosine riboside, a widely distributed nucleoside.”
- database_cross_reference “GOC:curators”

cytidine transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015212`

Removed

cytidine transmembrane transporter activity definition “Enables the transfer of cytidine, cytosine riboside, from one side of a membrane to the other.”
- database_cross_reference “GOC:go_curators”

Added

cytidine transmembrane transporter activity definition “Enables the transfer of cytidine, cytosine riboside, from one side of a membrane to the other.”
- database_cross_reference “GOC:curators”

cytidine transport `http://purl.obolibrary.org/obo/GO_0015861`

Removed

cytidine transport definition “The directed movement of cytidine, cytosine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:go_curators”

Added

cytidine transport definition “The directed movement of cytidine, cytosine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:curators”

cytochrome-c oxidase activity `http://purl.obolibrary.org/obo/GO_0004129`

Removed

cytochrome-c oxidase activity SubClassOf has part some oxidoreductase activity, acting on a heme group of donors

Added

cytochrome-c oxidase activity term tracker item “https://github.com/geneontology/go-ontology/issues/25935”^^anyURI
cytochrome-c oxidase activity SubClassOf oxidoreductase activity, acting on a heme group of donors

cytochrome-c peroxidase activity `http://purl.obolibrary.org/obo/GO_0004130`

Removed

cytochrome-c peroxidase activity definition “Catalysis of the reaction: 2 ferrocytochrome c + hydrogen peroxide = 2 ferricytochrome c + 2 H2O.”
- database_cross_reference “EC:1.11.1.5”

Added

cytochrome-c peroxidase activity definition “Catalysis of the reaction: 2 ferrocytochrome c + H2O2 = 2 ferricytochrome c + 2 H2O.”
- database_cross_reference “EC:1.11.1.5”

cytogamy `http://purl.obolibrary.org/obo/GO_0000755`

Removed

cytogamy definition “During conjugation with cellular fusion, the process resulting in creating a single cell from complementary mating types. The localized remodeling and dissolution of external protective structures allow the fusion of the plasma membranes and cytoplasmic mixing. An example of this process is found in Saccharomyces cerevisiae.”
- database_cross_reference “GOC:elh”

Added

cytogamy definition “A reproductive process in a single-celled organism in which the cytoplasm of two mating cells fuse, resulting in the formation of a single cell containing the combined cellular contents.”
- database_cross_reference “GOC:vw”
cytogamy term tracker item “https://github.com/geneontology/go-ontology/issues/31270”^^anyURI
cytogamy comment “Cytogamy follows cell recognition and mating projection formation (when present) and precedes or accompanies nuclear fusion (karyogamy).”
cytogamy SubClassOf cell-cell fusion

cytokinin catabolic process `http://purl.obolibrary.org/obo/GO_0009823`

Added

cytokinin catabolic process exactMatch PWY-2841
cytokinin catabolic process database_cross_reference “MetaCyc:PWY-2841”
cytokinin catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI

cytokinin dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0019139`

Removed

cytokinin dehydrogenase activity relatedMatch PWY-2841
cytokinin dehydrogenase activity comment “Note that this term has a MetaCyc pathway reference as the pathway only has a single step.”

Added

cytokinin dehydrogenase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI

cytoplasmic side of Golgi membrane `http://purl.obolibrary.org/obo/GO_0098548`

Removed

cytoplasmic side of Golgi membrane definition “The side (leaflet) of the Golgi membrane that faces the cytoplasm.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:ab”

Added

cytoplasmic side of Golgi membrane definition “The leaflet of the Golgi membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:ab”
cytoplasmic side of Golgi membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI

cytoplasmic side of apical plasma membrane `http://purl.obolibrary.org/obo/GO_0098592`

Removed

cytoplasmic side of apical plasma membrane definition “The side (leaflet) of the apical region of the plasma membrane that faces the cytoplasm.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:ab”

Added

cytoplasmic side of apical plasma membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
cytoplasmic side of apical plasma membrane definition “The leaflet of the apical region of the plasma membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:ab”

cytoplasmic side of cis-Golgi cisternae membrane `http://purl.obolibrary.org/obo/GO_0160278`

Removed

cytoplasmic side of cis-Golgi cisternae membrane definition “The membrane leaflet of the cis-Golgi cisternae membrane that faces the cytoplasm and is the site of interactions with cytosolic proteins, including those involved in vesicle budding, membrane tethering, and lipid or protein trafficking.”
- database_cross_reference “PMID:34597626”
- database_cross_reference “PMID:10922460”
- database_cross_reference “PMID:39331042”

Added

cytoplasmic side of cis-Golgi cisternae membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
cytoplasmic side of cis-Golgi cisternae membrane definition “The leaflet of the cis-Golgi cisternae membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it. This is the site of interactions with cytosolic proteins, including those involved in vesicle budding, membrane tethering, and lipid or protein trafficking.”
- database_cross_reference “PMID:34597626”
- database_cross_reference “PMID:10922460”
- database_cross_reference “PMID:39331042”

cytoplasmic side of cis-Golgi network membrane `http://purl.obolibrary.org/obo/GO_0140179`

Removed

cytoplasmic side of cis-Golgi network membrane definition “The leaflet of the membrane bilayer of the cis-Golgi network faces the cytoplasm and is where interactions with cytosolic proteins occur, including those for vesicle tethering, fusion, and Golgi-associated trafficking activities.”
- database_cross_reference “PMID:34080016”
- database_cross_reference “PMID:34597626”
- database_cross_reference “PMID:1747103”
- database_cross_reference “PMID:23913272”

Added

cytoplasmic side of cis-Golgi network membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
cytoplasmic side of cis-Golgi network membrane definition “The leaflet of the cis-Golgi network membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it. This is the site of interactions with cytosolic proteins, including those for vesicle tethering, fusion, and Golgi-associated trafficking activities.”
- database_cross_reference “PMID:34080016”
- database_cross_reference “PMID:34597626”
- database_cross_reference “PMID:1747103”
- database_cross_reference “PMID:23913272”

cytoplasmic side of dendritic spine plasma membrane `http://purl.obolibrary.org/obo/GO_1990780`

Removed

cytoplasmic side of dendritic spine plasma membrane definition “The leaflet of the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface surrounding a dendritic spine.”
- database_cross_reference “PMID:9275233”

Added

cytoplasmic side of dendritic spine plasma membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
cytoplasmic side of dendritic spine plasma membrane definition “The leaflet of the plasma membrane in the dendritic spine region that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “PMID:9275233”

cytoplasmic side of early endosome membrane `http://purl.obolibrary.org/obo/GO_0098559`

Removed

cytoplasmic side of early endosome membrane definition “The side (leaflet) of the early endosome membrane that faces the cytoplasm.”
- database_cross_reference “GOC:lr”

Added

cytoplasmic side of early endosome membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
cytoplasmic side of early endosome membrane definition “The leaflet of the early endosome membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:lr”

cytoplasmic side of endoplasmic reticulum membrane `http://purl.obolibrary.org/obo/GO_0098554`

Removed

cytoplasmic side of endoplasmic reticulum membrane definition “The side (leaflet) of the plasma membrane that faces the cytoplasm.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:ab”

Added

cytoplasmic side of endoplasmic reticulum membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
cytoplasmic side of endoplasmic reticulum membrane definition “The leaflet of the endoplasmic reticulum membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:ab”

cytoplasmic side of endosome membrane `http://purl.obolibrary.org/obo/GO_0010009`

Removed

cytoplasmic side of endosome membrane definition “The side (leaflet) of the endosome membrane that faces the cytoplasm.”
- database_cross_reference “GOC:lr”

Added

cytoplasmic side of endosome membrane definition “The leaflet of the endosome membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:lr”
cytoplasmic side of endosome membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI

cytoplasmic side of late endosome membrane `http://purl.obolibrary.org/obo/GO_0098560`

Removed

cytoplasmic side of late endosome membrane definition “The side (leaflet) of the late endosome membrane that faces the cytoplasm.”
- database_cross_reference “GOC:lr”

Added

cytoplasmic side of late endosome membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
cytoplasmic side of late endosome membrane definition “The leaflet of the late endosome membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:lr”

cytoplasmic side of lysosomal membrane `http://purl.obolibrary.org/obo/GO_0098574`

Removed

cytoplasmic side of lysosomal membrane definition “The side (leaflet) of the lysosomal membrane that faces the cytoplasm.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:ab”

Added

cytoplasmic side of lysosomal membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
cytoplasmic side of lysosomal membrane definition “The leaflet of the lysosomal membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:ab”

cytoplasmic side of medial-Golgi cisterna membrane `http://purl.obolibrary.org/obo/GO_0160279`

Removed

cytoplasmic side of medial-Golgi cisterna membrane definition “The membrane leaflet of the medial-Golgi cisternae that faces the cytoplasm participates in interactions with cytosolic proteins involved in membrane trafficking, vesicle docking, and cargo sorting.”
- database_cross_reference “PMID:28777890”
- database_cross_reference “PMID:34597626”
- database_cross_reference “PMID:39658747”

Added

cytoplasmic side of medial-Golgi cisterna membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
cytoplasmic side of medial-Golgi cisterna membrane definition “The leaflet of the medial-Golgi cisternae membrane that faces the cytoplasm,including any protein embedded in, attached to, or peripherally associated with it. This is the site of interactions with cytosolic proteins involved in membrane trafficking, vesicle docking, and cargo sorting.”
- database_cross_reference “PMID:28777890”
- database_cross_reference “PMID:34597626”
- database_cross_reference “PMID:39658747”

cytoplasmic side of membrane `http://purl.obolibrary.org/obo/GO_0098562`

Removed

cytoplasmic side of membrane definition “The side of a membrane that faces the cytoplasm.”
- database_cross_reference “GOC:dos”

Added

cytoplasmic side of membrane definition “The leaflet of a membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:dos”
cytoplasmic side of membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI

cytoplasmic side of mitochondrial outer membrane `http://purl.obolibrary.org/obo/GO_0032473`

Removed

cytoplasmic side of mitochondrial outer membrane definition “The external (cytoplasmic) face of the mitochondrial outer membrane.”
- database_cross_reference “GOC:mah”

Added

cytoplasmic side of mitochondrial outer membrane definition “The leaflet of the mitochondrial outer membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:mah”
cytoplasmic side of mitochondrial outer membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI

cytoplasmic side of plasma membrane `http://purl.obolibrary.org/obo/GO_0009898`

Removed

cytoplasmic side of plasma membrane definition “The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:tb”

Added

cytoplasmic side of plasma membrane definition “The leaflet of the plasma membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:tb”
cytoplasmic side of plasma membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI

cytoplasmic side of plasma membrane, cell tip `http://purl.obolibrary.org/obo/GO_0106186`

Removed

cytoplasmic side of plasma membrane, cell tip definition “The leaflet the plasma membrane at the cell tip that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.”
- database_cross_reference “GOC:vw”
- database_cross_reference “PMID:28292899”

Added

cytoplasmic side of plasma membrane, cell tip definition “The leaflet the plasma membrane at the cell tip that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:vw”
- database_cross_reference “PMID:28292899”
cytoplasmic side of plasma membrane, cell tip term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI

cytoplasmic side of rough endoplasmic reticulum membrane `http://purl.obolibrary.org/obo/GO_0098556`

Removed

cytoplasmic side of rough endoplasmic reticulum membrane definition “The side (leaflet) of the rough endoplasmic reticulum membrane that faces the cytoplasm.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:ab”

Added

cytoplasmic side of rough endoplasmic reticulum membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
cytoplasmic side of rough endoplasmic reticulum membrane definition “The leaflet of the rough endoplasmic reticulum membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:ab”

cytoplasmic side of smooth endoplasmic reticulum membrane `http://purl.obolibrary.org/obo/GO_0098557`

Removed

cytoplasmic side of smooth endoplasmic reticulum membrane definition “The side (leaflet) of the smooth endoplasmic reticulum membrane that faces the cytoplasm.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:ab”

Added

cytoplasmic side of smooth endoplasmic reticulum membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
cytoplasmic side of smooth endoplasmic reticulum membrane definition “The leaflet of the smooth endoplasmic reticulum membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:ab”

cytoplasmic side of trans-Golgi cisterna membrane `http://purl.obolibrary.org/obo/GO_0160288`

Removed

cytoplasmic side of trans-Golgi cisterna membrane definition “The membrane leaflet of the trans-Golgi cisternae that faces the cytoplasm. It is the site of protein and lipid interaction, vesicle formation, and cargo sorting towards post-Golgi destinations such as endosomes, lysosomes, and the plasma membrane.”
- database_cross_reference “PMID:34597626”
- database_cross_reference “PMID:37566051”
- database_cross_reference “PMID:23913272”

Added

cytoplasmic side of trans-Golgi cisterna membrane definition “The leaflet of the trans-Golgi cisternae membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it. This is the site where vesicle formation, and cargo sorting towards post-Golgi destinations such as endosomes, lysosomes and the plasma membrane occur.”
- database_cross_reference “PMID:34597626”
- database_cross_reference “PMID:37566051”
- database_cross_reference “PMID:23913272”
cytoplasmic side of trans-Golgi cisterna membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI

cytoplasmic side of trans-Golgi network membrane `http://purl.obolibrary.org/obo/GO_0160281`

Removed

cytoplasmic side of trans-Golgi network membrane definition “The leaflet of the membrane bilayer of the trans-Golgi network faces the cytoplasm and is crucial for lipid and protein sorting and trafficking, as it interacts with cytoplasmic proteins involved in vesicle formation and targeting.”
- database_cross_reference “PMID:34597626”
- database_cross_reference “PMID:10922460”
- database_cross_reference “PMID:23913272”

Added

cytoplasmic side of trans-Golgi network membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
cytoplasmic side of trans-Golgi network membrane definition “The leaflet of the trans-Golgi network membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it. This is the site of interaction where cytoplasmic proteins interact with proteins involved in vesicle formation and targeting.”
- database_cross_reference “PMID:34597626”
- database_cross_reference “PMID:10922460”
- database_cross_reference “PMID:23913272”

cytoplasmic side of trans-Golgi network transport vesicle membrane `http://purl.obolibrary.org/obo/GO_0098541`

Removed

cytoplasmic side of trans-Golgi network transport vesicle membrane definition “The side (leaflet) of the trans-Golgi network transport vesicle membrane that faces the cytoplasm.”
- database_cross_reference “GOC:ab”

Added

cytoplasmic side of trans-Golgi network transport vesicle membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
cytoplasmic side of trans-Golgi network transport vesicle membrane definition “The leaflet of the trans-Golgi network transport vesicle membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:ab”

cytoplasmic side of transport vesicle membrane `http://purl.obolibrary.org/obo/GO_0098539`

Removed

cytoplasmic side of transport vesicle membrane definition “The side (leaflet) of the transport vesicle membrane that faces the cytoplasm.”
- database_cross_reference “GOC:ab”

Added

cytoplasmic side of transport vesicle membrane definition “The leaflet of the transport vesicle membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:ab”
cytoplasmic side of transport vesicle membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI

cytosine catabolic process `http://purl.obolibrary.org/obo/GO_0006209`

Removed

cytosine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives.”
- database_cross_reference “GOC:go_curators”

Added

cytosine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives.”
- database_cross_reference “GOC:curators”

cytosine deaminase activity `http://purl.obolibrary.org/obo/GO_0004131`

Removed

cytosine deaminase activity definition “Catalysis of the reaction: cytosine + H2O = uracil + NH3.”
- database_cross_reference “EC:3.5.4.1”

Added

cytosine deaminase activity definition “Catalysis of the reaction: cytosine + H2O = uracil + NH4+.”
- database_cross_reference “RHEA:20605”

cytosine transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015209`

Removed

cytosine transmembrane transporter activity definition “Enables the transfer of cytosine, 4-amino-2-hydroxypyrimidine from one side of a membrane to the other.”
- database_cross_reference “GOC:go_curators”

Added

cytosine transmembrane transporter activity definition “Enables the transfer of cytosine, 4-amino-2-hydroxypyrimidine from one side of a membrane to the other.”
- database_cross_reference “GOC:curators”

cytosine transport `http://purl.obolibrary.org/obo/GO_0015856`

Removed

cytosine transport definition “The directed movement of cytosine, 4-amino-2-hydroxypyrimidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:go_curators”

Added

cytosine transport definition “The directed movement of cytosine, 4-amino-2-hydroxypyrimidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:curators”

cytoskeletal regulatory protein binding `http://purl.obolibrary.org/obo/GO_0005519`

Removed

cytoskeletal regulatory protein binding definition “Binding to a protein involved in modulating the reorganization of the cytoskeleton.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:15163540”

Added

cytoskeletal regulatory protein binding definition “Binding to a protein involved in modulating the reorganization of the cytoskeleton.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:15163540”

cytosol to Golgi apparatus transport `http://purl.obolibrary.org/obo/GO_0140820`

Added

cytosol to Golgi apparatus transport SubClassOf intercellular transport

cytosol to endoplasmic reticulum transport `http://purl.obolibrary.org/obo/GO_0046967`

Added

cytosol to endoplasmic reticulum transport SubClassOf intercellular transport

dADP catabolic process `http://purl.obolibrary.org/obo/GO_0046057`

Removed

dADP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of dADP, deoxyadenosine diphosphate (2’-deoxyadenosine 5’-diphosphate).”
- database_cross_reference “GOC:go_curators”

Added

dADP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of dADP, deoxyadenosine diphosphate (2’-deoxyadenosine 5’-diphosphate).”
- database_cross_reference “GOC:curators”

dADP metabolic process `http://purl.obolibrary.org/obo/GO_0046056`

Removed

dADP metabolic process definition “The chemical reactions and pathways involving dADP, deoxyadenosine diphosphate (2’-deoxyadenosine 5’-diphosphate).”
- database_cross_reference “GOC:go_curators”

Added

dADP metabolic process definition “The chemical reactions and pathways involving dADP, deoxyadenosine diphosphate (2’-deoxyadenosine 5’-diphosphate).”
- database_cross_reference “GOC:curators”

dAMP catabolic process `http://purl.obolibrary.org/obo/GO_0046059`

Removed

dAMP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of dAMP, deoxyadenosine monophosphate (2’-deoxyadenosine 5’-phosphate).”
- database_cross_reference “GOC:go_curators”

Added

dAMP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of dAMP, deoxyadenosine monophosphate (2’-deoxyadenosine 5’-phosphate).”
- database_cross_reference “GOC:curators”

dAMP metabolic process `http://purl.obolibrary.org/obo/GO_0046053`

Removed

dAMP metabolic process definition “The chemical reactions and pathways involving dAMP, deoxyadenosine monophosphate (2’-deoxyadenosine 5’-phosphate).”
- database_cross_reference “GOC:go_curators”

Added

dAMP metabolic process definition “The chemical reactions and pathways involving dAMP, deoxyadenosine monophosphate (2’-deoxyadenosine 5’-phosphate).”
- database_cross_reference “GOC:curators”

dATP catabolic process `http://purl.obolibrary.org/obo/GO_0046061`

Removed

dATP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of dATP, deoxyadenosine triphosphate (2’-deoxyadenosine 5’-triphosphate).”
- database_cross_reference “GOC:go_curators”

Added

dATP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of dATP, deoxyadenosine triphosphate (2’-deoxyadenosine 5’-triphosphate).”
- database_cross_reference “GOC:curators”

dATP metabolic process `http://purl.obolibrary.org/obo/GO_0046060`

Removed

dATP metabolic process definition “The chemical reactions and pathways involving dATP, deoxyadenosine triphosphate (2’-deoxyadenosine 5’-triphosphate).”
- database_cross_reference “GOC:go_curators”

Added

dATP metabolic process definition “The chemical reactions and pathways involving dATP, deoxyadenosine triphosphate (2’-deoxyadenosine 5’-triphosphate).”
- database_cross_reference “GOC:curators”

dCDP metabolic process `http://purl.obolibrary.org/obo/GO_0046062`

Removed

dCDP metabolic process definition “The chemical reactions and pathways involving dCDP, deoxycytidine 5’-diphosphate.”
- database_cross_reference “GOC:go_curators”

Added

dCDP metabolic process definition “The chemical reactions and pathways involving dCDP, deoxycytidine 5’-diphosphate.”
- database_cross_reference “GOC:curators”

dCMP biosynthetic process `http://purl.obolibrary.org/obo/GO_0046064`

Removed

dCMP biosynthetic process definition “The chemical reactions and pathways resulting in the formation of dCMP, deoxycytidine monophosphate.”
- database_cross_reference “GOC:go_curators”

Added

dCMP biosynthetic process definition “The chemical reactions and pathways resulting in the formation of dCMP, deoxycytidine monophosphate.”
- database_cross_reference “GOC:curators”

dCMP deaminase activity `http://purl.obolibrary.org/obo/GO_0004132`

Removed

dCMP deaminase activity definition “Catalysis of the reaction: dCMP + H2O = dUMP + NH3.”
- database_cross_reference “EC:3.5.4.12”

Added

dCMP deaminase activity definition “Catalysis of the reaction: dCMP + H2O = dUMP + NH4+.”
- database_cross_reference “RHEA:22924”

dCMP metabolic process `http://purl.obolibrary.org/obo/GO_0046063`

Removed

dCMP metabolic process definition “The chemical reactions and pathways involving dCMP, deoxycytidine monophosphate.”
- database_cross_reference “GOC:go_curators”

Added

dCMP metabolic process definition “The chemical reactions and pathways involving dCMP, deoxycytidine monophosphate.”
- database_cross_reference “GOC:curators”

dCTP deaminase activity `http://purl.obolibrary.org/obo/GO_0008829`

Removed

dCTP deaminase activity definition “Catalysis of the reaction: dCTP + H2O = dUTP + NH3.”
- database_cross_reference “EC:3.5.4.13”

Added

dCTP deaminase activity definition “Catalysis of the reaction: dCTP + H2O + H+ = dUTP + NH4+.”
- database_cross_reference “RHEA:22680”

dCTP metabolic process `http://purl.obolibrary.org/obo/GO_0046065`

Removed

dCTP metabolic process definition “The chemical reactions and pathways involving dCTP, deoxycytidine triphosphate.”
- database_cross_reference “GOC:go_curators”

Added

dCTP metabolic process definition “The chemical reactions and pathways involving dCTP, deoxycytidine triphosphate.”
- database_cross_reference “GOC:curators”

dGDP catabolic process `http://purl.obolibrary.org/obo/GO_0046067`

Removed

dGDP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of dGDP, deoxyguanosine diphosphate, (2’-deoxyguanosine 5’-diphosphate).”
- database_cross_reference “GOC:go_curators”

Added

dGDP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of dGDP, deoxyguanosine diphosphate, (2’-deoxyguanosine 5’-diphosphate).”
- database_cross_reference “GOC:curators”

dGDP metabolic process `http://purl.obolibrary.org/obo/GO_0046066`

Removed

dGDP metabolic process definition “The chemical reactions and pathways involving dGDP, deoxyguanosine diphosphate, (2’-deoxyguanosine 5’-diphosphate).”
- database_cross_reference “GOC:go_curators”

Added

dGDP metabolic process definition “The chemical reactions and pathways involving dGDP, deoxyguanosine diphosphate, (2’-deoxyguanosine 5’-diphosphate).”
- database_cross_reference “GOC:curators”

dGMP catabolic process `http://purl.obolibrary.org/obo/GO_0046055`

Removed

dGMP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of dGMP, deoxyguanosine monophosphate (2’-deoxyguanosine 5’-phosphate).”
- database_cross_reference “GOC:go_curators”

Added

dGMP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of dGMP, deoxyguanosine monophosphate (2’-deoxyguanosine 5’-phosphate).”
- database_cross_reference “GOC:curators”

dGMP metabolic process `http://purl.obolibrary.org/obo/GO_0046054`

Removed

dGMP metabolic process definition “The chemical reactions and pathways involving dGMP, deoxyguanosine monophosphate (2’-deoxyguanosine 5’-phosphate).”
- database_cross_reference “GOC:go_curators”

Added

dGMP metabolic process definition “The chemical reactions and pathways involving dGMP, deoxyguanosine monophosphate (2’-deoxyguanosine 5’-phosphate).”
- database_cross_reference “GOC:curators”

dGTP biosynthetic process `http://purl.obolibrary.org/obo/GO_0046071`

Removed

dGTP biosynthetic process definition “The chemical reactions and pathways resulting in the formation of dGTP, guanosine triphosphate.”
- database_cross_reference “GOC:go_curators”

Added

dGTP biosynthetic process definition “The chemical reactions and pathways resulting in the formation of dGTP, guanosine triphosphate.”
- database_cross_reference “GOC:curators”

dGTP metabolic process `http://purl.obolibrary.org/obo/GO_0046070`

Removed

dGTP metabolic process definition “The chemical reactions and pathways involving dGTP, guanosine triphosphate.”
- database_cross_reference “GOC:go_curators”

Added

dGTP metabolic process definition “The chemical reactions and pathways involving dGTP, guanosine triphosphate.”
- database_cross_reference “GOC:curators”

dTDP metabolic process `http://purl.obolibrary.org/obo/GO_0046072`

Removed

dTDP metabolic process definition “The chemical reactions and pathways involving dTDP, deoxyribosylthymine diphosphate.”
- database_cross_reference “GOC:go_curators”

Added

dTDP metabolic process definition “The chemical reactions and pathways involving dTDP, deoxyribosylthymine diphosphate.”
- database_cross_reference “GOC:curators”

dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0019179`

Removed

dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate.”
- database_cross_reference “EC:2.6.1.33”
dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate transaminase activity label “dTDP-4-amino-4,6-dideoxy-D-glucose transaminase activity”

Added

dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate transaminase activity has_exact_synonym “dTDP-4-amino-4,6-dideoxy-D-glucose transaminase activity”
dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate.”
- database_cross_reference “RHEA:19085”
dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate transaminase activity label “dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate transaminase activity”

dTDP-4-amino-4,6-dideoxygalactose:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0019180`

Removed

dTDP-4-amino-4,6-dideoxygalactose:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose = L-glutamate + dTDP-4-dehydro-6-deoxy-D-galactose.”
- database_cross_reference “RHEA:10368”
- database_cross_reference “EC:2.6.1.59”
dTDP-4-amino-4,6-dideoxygalactose:2-oxoglutarate transaminase activity label “dTDP-4-amino-4,6-dideoxygalactose transaminase activity”

Added

dTDP-4-amino-4,6-dideoxygalactose:2-oxoglutarate transaminase activity has_exact_synonym “dTDP-4-amino-4,6-dideoxygalactose transaminase activity”
dTDP-4-amino-4,6-dideoxygalactose:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
dTDP-4-amino-4,6-dideoxygalactose:2-oxoglutarate transaminase activity label “dTDP-4-amino-4,6-dideoxygalactose:2-oxoglutarate transaminase activity”
dTDP-4-amino-4,6-dideoxygalactose:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-alpha-D-galactose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate.”
- database_cross_reference “RHEA:10368”

dTMP catabolic process `http://purl.obolibrary.org/obo/GO_0046074`

Removed

dTMP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of dTMP, deoxyribosylthymine monophosphate.”
- database_cross_reference “GOC:go_curators”

Added

dTMP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of dTMP, deoxyribosylthymine monophosphate.”
- database_cross_reference “GOC:curators”

dTMP metabolic process `http://purl.obolibrary.org/obo/GO_0046073`

Removed

dTMP metabolic process definition “The chemical reactions and pathways involving dTMP, deoxyribosylthymine monophosphate (2’-deoxyribosylthymine 5’-phosphate).”
- database_cross_reference “GOC:go_curators”

Added

dTMP metabolic process definition “The chemical reactions and pathways involving dTMP, deoxyribosylthymine monophosphate (2’-deoxyribosylthymine 5’-phosphate).”
- database_cross_reference “GOC:curators”

dTTP catabolic process `http://purl.obolibrary.org/obo/GO_0046076`

Removed

dTTP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of dTTP, deoxyribosylthymine triphosphate.”
- database_cross_reference “GOC:go_curators”

Added

dTTP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of dTTP, deoxyribosylthymine triphosphate.”
- database_cross_reference “GOC:curators”

dTTP metabolic process `http://purl.obolibrary.org/obo/GO_0046075`

Removed

dTTP metabolic process definition “The chemical reactions and pathways involving dTTP, deoxyribosylthymine triphosphate.”
- database_cross_reference “GOC:go_curators”

Added

dTTP metabolic process definition “The chemical reactions and pathways involving dTTP, deoxyribosylthymine triphosphate.”
- database_cross_reference “GOC:curators”

dUDP metabolic process `http://purl.obolibrary.org/obo/GO_0046077`

Removed

dUDP metabolic process definition “The chemical reactions and pathways involving dUDP, deoxyuridine (5’-)diphosphate.”
- database_cross_reference “GOC:go_curators”

Added

dUDP metabolic process definition “The chemical reactions and pathways involving dUDP, deoxyuridine (5’-)diphosphate.”
- database_cross_reference “GOC:curators”

dUMP catabolic process `http://purl.obolibrary.org/obo/GO_0046079`

Removed

dUMP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of dUMP, deoxyuridine (5’-)monophosphate.”
- database_cross_reference “GOC:go_curators”

Added

dUMP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of dUMP, deoxyuridine (5’-)monophosphate.”
- database_cross_reference “GOC:curators”

dUMP metabolic process `http://purl.obolibrary.org/obo/GO_0046078`

Removed

dUMP metabolic process definition “The chemical reactions and pathways involving dUMP, deoxyuridine (5’-)monophosphate (2’-deoxyuridine 5’-phosphate).”
- database_cross_reference “GOC:go_curators”

Added

dUMP metabolic process definition “The chemical reactions and pathways involving dUMP, deoxyuridine (5’-)monophosphate (2’-deoxyuridine 5’-phosphate).”
- database_cross_reference “GOC:curators”

dUTP catabolic process `http://purl.obolibrary.org/obo/GO_0046081`

Removed

dUTP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5’-)triphosphate.”
- database_cross_reference “GOC:go_curators”

Added

dUTP catabolic process definition “The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5’-)triphosphate.”
- database_cross_reference “GOC:curators”

dUTP metabolic process `http://purl.obolibrary.org/obo/GO_0046080`

Removed

dUTP metabolic process definition “The chemical reactions and pathways involving dUTP, deoxyuridine (5’-)triphosphate.”
- database_cross_reference “GOC:go_curators”

Added

dUTP metabolic process definition “The chemical reactions and pathways involving dUTP, deoxyuridine (5’-)triphosphate.”
- database_cross_reference “GOC:curators”

deaminase activity `http://purl.obolibrary.org/obo/GO_0019239`

Removed

deaminase activity database_cross_reference “Reactome:R-HSA-9014641”
- label “HRSP12 deaminates 2AA to 2OBUTA”
deaminase activity definition “Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R).”
- database_cross_reference “GOC:jl”

Added

deaminase activity definition “Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH4+/NH2R).”
- database_cross_reference “GOC:jl”

defense response `http://purl.obolibrary.org/obo/GO_0006952`

Removed

defense response definition “Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.”
- database_cross_reference “GOC:go_curators”

Added

defense response definition “Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.”
- database_cross_reference “GOC:curators”

defense response to symbiont `http://purl.obolibrary.org/obo/GO_0140546`

Added

defense response to symbiont database_cross_reference “Reactome:R-HSA-9953170”
- label “GBP-mediated host defense”

dehydroascorbic acid transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0033300`

Removed

dehydroascorbic acid transmembrane transporter activity definition “Enables the transfer of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, from one side of a membrane to the other.”
- database_cross_reference “GOC:go_curators”

Added

dehydroascorbic acid transmembrane transporter activity definition “Enables the transfer of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, from one side of a membrane to the other.”
- database_cross_reference “GOC:curators”

delta(3)-delta(2)-enoyl-CoA isomerase activity `http://purl.obolibrary.org/obo/GO_0004165`

Added

delta(3)-delta(2)-enoyl-CoA isomerase activity narrowMatch 46044
delta(3)-delta(2)-enoyl-CoA isomerase activity database_cross_reference “RHEA:77195”
delta(3)-delta(2)-enoyl-CoA isomerase activity database_cross_reference “RHEA:29847”
delta(3)-delta(2)-enoyl-CoA isomerase activity narrowMatch 29847
delta(3)-delta(2)-enoyl-CoA isomerase activity narrowMatch 45748
delta(3)-delta(2)-enoyl-CoA isomerase activity database_cross_reference “RHEA:46044”
delta(3)-delta(2)-enoyl-CoA isomerase activity database_cross_reference “RHEA:45748”
delta(3)-delta(2)-enoyl-CoA isomerase activity narrowMatch 77195

delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity `http://purl.obolibrary.org/obo/GO_0051750`

Added

delta1-piperideine-2-carboxylate reductase activity `http://purl.obolibrary.org/obo/GO_0047125`

Added

delta1-piperideine-2-carboxylate reductase activity database_cross_reference “Reactome:R-HSA-5693347”
- label “CRYM reduces P2C to PPCA”

delta7-sterol 5(6)-desaturase activity `http://purl.obolibrary.org/obo/GO_0050046`

Added

delta7-sterol 5(6)-desaturase activity database_cross_reference “RHEA:46560”
delta7-sterol 5(6)-desaturase activity database_cross_reference “RHEA:46556”
delta7-sterol 5(6)-desaturase activity narrowMatch 46560
delta7-sterol 5(6)-desaturase activity narrowMatch 46556

delta9-tetrahydrocannabinolate synthase activity `http://purl.obolibrary.org/obo/GO_0102778`

Removed

delta9-tetrahydrocannabinolate synthase activity definition “Catalysis of the reaction: cannabigerolate + O2 = delta(9)-tetrahydrocannabinolic acid + hydrogen peroxide.”
- database_cross_reference “GOC:pz”
- database_cross_reference “RHEA:34135”

Added

delta9-tetrahydrocannabinolate synthase activity definition “Catalysis of the reaction: cannabigerolate + O2 = delta(9)-tetrahydrocannabinolic acid + H2O2.”
- database_cross_reference “RHEA:34135”

denitrification pathway `http://purl.obolibrary.org/obo/GO_0019333`

Removed

denitrification pathway SubClassOf has part some nitrate reductase activity

Added

denitrification pathway narrowMatch PWY-6748
denitrification pathway narrowMatch PWY-7084
denitrification pathway database_cross_reference “MetaCyc:PWY-7084”
denitrification pathway term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
denitrification pathway narrowMatch DENITRIFICATION-PWY
denitrification pathway database_cross_reference “MetaCyc:PWY-6748”

deoxyadenosine biosynthetic process `http://purl.obolibrary.org/obo/GO_0046091`

Removed

deoxyadenosine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA.”
- database_cross_reference “GOC:go_curators”

Added

deoxyadenosine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA.”
- database_cross_reference “GOC:curators”
deoxyadenosine biosynthetic process SubClassOf 2’-deoxyribonucleoside biosynthetic process

deoxyadenosine catabolic process `http://purl.obolibrary.org/obo/GO_0006157`

Removed

deoxyadenosine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA.”
- database_cross_reference “GOC:go_curators”

Added

deoxyadenosine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA.”
- database_cross_reference “GOC:curators”
deoxyadenosine catabolic process SubClassOf 2’-deoxyribonucleoside catabolic process

deoxyadenosine metabolic process `http://purl.obolibrary.org/obo/GO_0046090`

Removed

deoxyadenosine metabolic process definition “The chemical reactions and pathways involving deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA.”
- database_cross_reference “GOC:go_curators”

Added

deoxyadenosine metabolic process definition “The chemical reactions and pathways involving deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA.”
- database_cross_reference “GOC:curators”
deoxyadenosine metabolic process SubClassOf 2’-deoxyribonucleoside metabolic process

deoxycytidine biosynthetic process `http://purl.obolibrary.org/obo/GO_0046093`

Removed

deoxycytidine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA.”
- database_cross_reference “GOC:go_curators”

Added

deoxycytidine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA.”
- database_cross_reference “GOC:curators”

deoxycytidine catabolic process `http://purl.obolibrary.org/obo/GO_0006217`

Removed

deoxycytidine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA.”
- database_cross_reference “GOC:go_curators”

Added

deoxycytidine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA.”
- database_cross_reference “GOC:curators”

deoxycytidine kinase activity `http://purl.obolibrary.org/obo/GO_0004137`

Added

deoxycytidine kinase activity narrowMatch 46040
deoxycytidine kinase activity database_cross_reference “RHEA:46040”
deoxycytidine kinase activity database_cross_reference “RHEA:46036”
deoxycytidine kinase activity narrowMatch 46036

deoxycytidine metabolic process `http://purl.obolibrary.org/obo/GO_0046092`

Removed

deoxycytidine metabolic process definition “The chemical reactions and pathways involving deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA.”
- database_cross_reference “GOC:go_curators”

Added

deoxycytidine metabolic process definition “The chemical reactions and pathways involving deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA.”
- database_cross_reference “GOC:curators”

deoxyguanosine biosynthetic process `http://purl.obolibrary.org/obo/GO_0042452`

Added

deoxyguanosine biosynthetic process SubClassOf 2’-deoxyribonucleoside biosynthetic process

deoxyguanosine catabolic process `http://purl.obolibrary.org/obo/GO_0006161`

Added

deoxyguanosine catabolic process SubClassOf 2’-deoxyribonucleoside catabolic process

deoxyinosine biosynthetic process `http://purl.obolibrary.org/obo/GO_0046095`

Removed

deoxyinosine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of deoxyinosine, hypoxanthine deoxyriboside.”
- database_cross_reference “GOC:go_curators”

Added

deoxyinosine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of deoxyinosine, hypoxanthine deoxyriboside.”
- database_cross_reference “GOC:curators”
deoxyinosine biosynthetic process SubClassOf 2’-deoxyribonucleoside biosynthetic process

deoxyinosine catabolic process `http://purl.obolibrary.org/obo/GO_0006149`

Removed

deoxyinosine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of deoxyinosine, hypoxanthine deoxyriboside.”
- database_cross_reference “GOC:go_curators”

Added

deoxyinosine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of deoxyinosine, hypoxanthine deoxyriboside.”
- database_cross_reference “GOC:curators”
deoxyinosine catabolic process SubClassOf 2’-deoxyribonucleoside catabolic process

deoxyinosine metabolic process `http://purl.obolibrary.org/obo/GO_0046094`

Removed

deoxyinosine metabolic process definition “The chemical reactions and pathways involving deoxyinosine, hypoxanthine deoxyriboside.”
- database_cross_reference “GOC:go_curators”

Added

deoxyinosine metabolic process definition “The chemical reactions and pathways involving deoxyinosine, hypoxanthine deoxyriboside.”
- database_cross_reference “GOC:curators”
deoxyinosine metabolic process SubClassOf 2’-deoxyribonucleoside metabolic process

deoxynucleoside kinase activity `http://purl.obolibrary.org/obo/GO_0019136`

Added

deoxynucleoside kinase activity narrowMatch 28206
deoxynucleoside kinase activity database_cross_reference “RHEA:28206”

deoxynucleoside phosphate kinase activity, ATP as phosphate donor `http://purl.obolibrary.org/obo/GO_0047507`

Added

deoxynucleoside phosphate kinase activity, GTP as phosphate donor `http://purl.obolibrary.org/obo/GO_0106369`

Added

deoxynucleoside phosphate kinase activity, dGTP as phosphate donor `http://purl.obolibrary.org/obo/GO_0106367`

Added

deoxynucleoside phosphate kinase activity, dTTP as phosphate donor `http://purl.obolibrary.org/obo/GO_0106368`

Added

deoxynucleoside triphosphate hydrolase activity `http://purl.obolibrary.org/obo/GO_0106375`

Added

deoxyribonucleoside diphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009189`

Removed

deoxyribonucleoside diphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

deoxyribonucleoside diphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

deoxyribonucleoside diphosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009192`

Removed

deoxyribonucleoside diphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

deoxyribonucleoside diphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

deoxyribonucleoside monophosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009157`

Removed

deoxyribonucleoside monophosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

deoxyribonucleoside monophosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

deoxyribonucleoside monophosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009159`

Removed

deoxyribonucleoside monophosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

deoxyribonucleoside monophosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

deoxyribonucleoside triphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009202`

Removed

deoxyribonucleoside triphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

deoxyribonucleoside triphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

deoxyribonucleoside triphosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009204`

Removed

deoxyribonucleoside triphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

deoxyribonucleoside triphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

deoxyribonucleoside triphosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009200`

Removed

deoxyribonucleoside triphosphate metabolic process definition “The chemical reactions and pathways involving a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

deoxyribonucleoside triphosphate metabolic process definition “The chemical reactions and pathways involving a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

deoxyribonucleotide binding `http://purl.obolibrary.org/obo/GO_0032552`

Removed

deoxyribonucleotide binding SubClassOf carbohydrate derivative binding
deoxyribonucleotide binding SubClassOf nucleotide binding

Added

deoxyribonucleotide binding term tracker item “https://github.com/geneontology/go-ontology/issues/27059”^^anyURI
deoxyribonucleotide binding SubClassOf binding

deoxyribonucleotide biosynthetic process `http://purl.obolibrary.org/obo/GO_0009263`

Removed

deoxyribonucleotide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”
deoxyribonucleotide biosynthetic process SubClassOf carbohydrate derivative biosynthetic process
deoxyribonucleotide biosynthetic process SubClassOf nucleotide biosynthetic process

Added

deoxyribonucleotide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:curators”
deoxyribonucleotide biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/27059”^^anyURI
deoxyribonucleotide biosynthetic process SubClassOf biosynthetic process

deoxyribonucleotide catabolic process `http://purl.obolibrary.org/obo/GO_0009264`

Removed

deoxyribonucleotide catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”
deoxyribonucleotide catabolic process SubClassOf carbohydrate derivative catabolic process
deoxyribonucleotide catabolic process SubClassOf nucleotide catabolic process

Added

deoxyribonucleotide catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/27059”^^anyURI
deoxyribonucleotide catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:curators”
deoxyribonucleotide catabolic process SubClassOf catabolic process

deoxyribonucleotide metabolic process `http://purl.obolibrary.org/obo/GO_0009262`

Removed

deoxyribonucleotide metabolic process definition “The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”
deoxyribonucleotide metabolic process SubClassOf nucleotide metabolic process
deoxyribonucleotide metabolic process SubClassOf carbohydrate derivative metabolic process

Added

deoxyribonucleotide metabolic process definition “The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:curators”
deoxyribonucleotide metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/27059”^^anyURI
deoxyribonucleotide metabolic process SubClassOf metabolic process

deoxyuridine biosynthetic process `http://purl.obolibrary.org/obo/GO_0046097`

Removed

deoxyuridine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA.”
- database_cross_reference “GOC:go_curators”

Added

deoxyuridine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA.”
- database_cross_reference “GOC:curators”

deoxyuridine catabolic process `http://purl.obolibrary.org/obo/GO_0006219`

Removed

deoxyuridine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA.”
- database_cross_reference “GOC:go_curators”

Added

deoxyuridine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA.”
- database_cross_reference “GOC:curators”

deoxyuridine metabolic process `http://purl.obolibrary.org/obo/GO_0046096`

Removed

deoxyuridine metabolic process definition “The chemical reactions and pathways involving deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA.”
- database_cross_reference “GOC:go_curators”

Added

deoxyuridine metabolic process definition “The chemical reactions and pathways involving deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA.”
- database_cross_reference “GOC:curators”

depsipeptide biosynthetic process `http://purl.obolibrary.org/obo/GO_0050763`

Removed

depsipeptide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively.”
- database_cross_reference “GOC:go_curators”

Added

depsipeptide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively.”
- database_cross_reference “GOC:curators”

depsipeptide catabolic process `http://purl.obolibrary.org/obo/GO_0050762`

Removed

depsipeptide catabolic process definition “The chemical reactions and pathways resulting in the breakdown of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively.”
- database_cross_reference “GOC:go_curators”

Added

depsipeptide catabolic process definition “The chemical reactions and pathways resulting in the breakdown of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively.”
- database_cross_reference “GOC:curators”

depsipeptide metabolic process `http://purl.obolibrary.org/obo/GO_0050761`

Removed

depsipeptide metabolic process definition “The chemical reactions and pathways involving depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively.”
- database_cross_reference “GOC:go_curators”

Added

depsipeptide metabolic process definition “The chemical reactions and pathways involving depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively.”
- database_cross_reference “GOC:curators”

dermatan sulfate proteoglycan biosynthetic process `http://purl.obolibrary.org/obo/GO_0050651`

Added

dermatan sulfate proteoglycan biosynthetic process database_cross_reference “Reactome:R-HSA-2022923”
- label “DS-GAG biosynthesis”

detection of UV `http://purl.obolibrary.org/obo/GO_0009589`

Removed

detection of UV definition “The series of events in which an ultraviolet radiation (UV light) stimulus is received and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:hb”
- database_cross_reference “ISBN:0198506732”

Added

detection of UV definition “The series of events in which an ultraviolet radiation (UV light) stimulus is received and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:hb”
- database_cross_reference “ISBN:0198506732”

detection of chemical stimulus involved in sensory perception of bitter taste `http://purl.obolibrary.org/obo/GO_0001580`

Removed

detection of chemical stimulus involved in sensory perception of bitter taste definition “The series of events required for a bitter taste stimulus to be received and converted to a molecular signal.”
- database_cross_reference “GOC:go_curators”

Added

detection of chemical stimulus involved in sensory perception of bitter taste definition “The series of events required for a bitter taste stimulus to be received and converted to a molecular signal.”
- database_cross_reference “GOC:curators”

detection of chemical stimulus involved in sensory perception of sour taste `http://purl.obolibrary.org/obo/GO_0001581`

Removed

detection of chemical stimulus involved in sensory perception of sour taste definition “The series of events required for a sour taste stimulus to be received and converted to a molecular signal.”
- database_cross_reference “GOC:go_curators”

Added

detection of chemical stimulus involved in sensory perception of sour taste definition “The series of events required for a sour taste stimulus to be received and converted to a molecular signal.”
- database_cross_reference “GOC:curators”

detection of chemical stimulus involved in sensory perception of sweet taste `http://purl.obolibrary.org/obo/GO_0001582`

Removed

detection of chemical stimulus involved in sensory perception of sweet taste definition “The series of events required for a sweet taste stimulus to be received and converted to a molecular signal.”
- database_cross_reference “GOC:go_curators”

Added

detection of chemical stimulus involved in sensory perception of sweet taste definition “The series of events required for a sweet taste stimulus to be received and converted to a molecular signal.”
- database_cross_reference “GOC:curators”

detection of light stimulus `http://purl.obolibrary.org/obo/GO_0009583`

Removed

detection of light stimulus definition “The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal.”
- database_cross_reference “GOC:go_curators”

Added

detection of light stimulus definition “The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal.”
- database_cross_reference “GOC:curators”

detection of visible light `http://purl.obolibrary.org/obo/GO_0009584`

Removed

detection of visible light definition “The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

detection of visible light definition “The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

determination of bilateral symmetry `http://purl.obolibrary.org/obo/GO_0009855`

Removed

determination of bilateral symmetry definition “The establishment of an organism’s body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.”
- database_cross_reference “GOC:go_curators”

Added

determination of bilateral symmetry definition “The establishment of an organism’s body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.”
- database_cross_reference “GOC:curators”

determination of radial symmetry `http://purl.obolibrary.org/obo/GO_0009879`

Removed

determination of radial symmetry definition “The establishment of an organism’s body plan or a part of an organism such that it is symmetric around a central axis.”
- database_cross_reference “GOC:go_curators”

Added

determination of radial symmetry definition “The establishment of an organism’s body plan or a part of an organism such that it is symmetric around a central axis.”
- database_cross_reference “GOC:curators”

deubiquitinase activity `http://purl.obolibrary.org/obo/GO_0101005`

Added

deubiquitinase activity database_cross_reference “Reactome:R-HSA-9929353”
- label “Deubiquitination of CD274”

developmental cell growth `http://purl.obolibrary.org/obo/GO_0048588`

Removed

developmental cell growth definition “The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another.”
- database_cross_reference “GOC:isa_complete”
- database_cross_reference “GOC:go_curators”

Added

developmental cell growth definition “The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:isa_complete”

developmental growth `http://purl.obolibrary.org/obo/GO_0048589`

Removed

developmental growth definition “The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.”
- database_cross_reference “GOC:go_curators”

Added

developmental growth definition “The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.”
- database_cross_reference “GOC:curators”

diacylglycerol O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0004144`

Added

diacylglycerol O-acyltransferase activity database_cross_reference “RHEA:38219”
diacylglycerol O-acyltransferase activity narrowMatch 56536
diacylglycerol O-acyltransferase activity database_cross_reference “RHEA:38307”
diacylglycerol O-acyltransferase activity narrowMatch 38307
diacylglycerol O-acyltransferase activity narrowMatch 38299
diacylglycerol O-acyltransferase activity database_cross_reference “RHEA:38163”
diacylglycerol O-acyltransferase activity narrowMatch 38219
diacylglycerol O-acyltransferase activity narrowMatch 38163
diacylglycerol O-acyltransferase activity database_cross_reference “RHEA:56536”
diacylglycerol O-acyltransferase activity database_cross_reference “RHEA:38299”

diacylglycerol cholinephosphotransferase activity `http://purl.obolibrary.org/obo/GO_0004142`

Added

diacylglycerol diphosphate phosphatase activity `http://purl.obolibrary.org/obo/GO_0000810`

Added

diacylglycerol lipase activity `http://purl.obolibrary.org/obo/GO_0120516`

Added

diacylglycerol lipase activity database_cross_reference “RHEA:78019”
diacylglycerol lipase activity database_cross_reference “RHEA:47868”
diacylglycerol lipase activity database_cross_reference “RHEA:44444”
diacylglycerol lipase activity narrowMatch 47868
diacylglycerol lipase activity narrowMatch 44444
diacylglycerol lipase activity narrowMatch 78019

diacylglycerol-dependent serine/threonine kinase activity `http://purl.obolibrary.org/obo/GO_0004697`

Removed

diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9010681”
- label “PKC phosphorylates ROBO3.1”
diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-8932284”
- label “PKC phosphorylates NFE2L2”
diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-5625784”
- label “PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters”
diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-450550”
- label “PKCalpha phosphorylates HuR”
diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-429698”
- label “PRKD1,2,3 phosphorylates CERT1-2”
diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-1433508”
- label “PKC alpha interacts with and phosphorylates KIT”
diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9796053”
- label “PRKCI phosphorylates NFE2L2”
diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-5138432”
- label “DVL2 is phosphorylated by PKC”
diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-927889”
- label “SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)”
diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-5218823”
- label “PKC phosphorylates sphingosine kinase 1”
diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-450533”
- label “PKCdelta phosphorylates HuR”
diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-374664”
- label “Phosphorylation and activation of Ezrin”
diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-198314”
- label “DAG stimulates protein kinase C-delta”
diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9632858”
- label “PRKCZ autophosphorylates downstream of estrogen stimulation”
diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-5623667”
- label “PDPK1 phosphorylates PKN1,2,3”
diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-5671749”
- label “p-T774-PKN1 phosphorylates CDC25C”
diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9021357”
- label “PRKCI phosphorylates ELF3”
diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-2179413”
- label “Activated PKC-alpha activate MMP3”
diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-2730863”
- label “Phosphorylation of CARMA1 by PKC-theta”
diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-8934446”
- label “Activated PKC phosphorylates SHC1”
diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-909552”
- label “Phosphorylation of STAT1 at Ser727”
diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-74615”
- label “PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP”
diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-5229194”
- label “Depolymerization of lamin filaments after PKC-mediated phosphorylation”
diacylglycerol-dependent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-193703”
- label “IKKbeta is activated”

diacylglycerol-dependent, calcium-independent serine/threonine kinase activity `http://purl.obolibrary.org/obo/GO_0004699`

Added

diacylglycerol-dependent, calcium-independent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-909552”
- label “Phosphorylation of STAT1 at Ser727”
diacylglycerol-dependent, calcium-independent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-198314”
- label “DAG stimulates protein kinase C-delta”
diacylglycerol-dependent, calcium-independent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-429698”
- label “PRKD1,2,3 phosphorylates CERT1-2”
diacylglycerol-dependent, calcium-independent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-2730863”
- label “Phosphorylation of CARMA1 by PKC-theta”
diacylglycerol-dependent, calcium-independent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-8932284”
- label “PKC phosphorylates NFE2L2”
diacylglycerol-dependent, calcium-independent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-450533”
- label “PKCdelta phosphorylates HuR”
diacylglycerol-dependent, calcium-independent serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-374664”
- label “Phosphorylation and activation of Ezrin”

diamine N-acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0004145`

Added

diamine N-acetyltransferase activity database_cross_reference “RHEA:25181”
diamine N-acetyltransferase activity narrowMatch 28270
diamine N-acetyltransferase activity database_cross_reference “RHEA:28150”
diamine N-acetyltransferase activity narrowMatch 79547
diamine N-acetyltransferase activity narrowMatch 28150
diamine N-acetyltransferase activity database_cross_reference “RHEA:28270”
diamine N-acetyltransferase activity narrowMatch 79551
diamine N-acetyltransferase activity narrowMatch 25181
diamine N-acetyltransferase activity database_cross_reference “RHEA:79551”
diamine N-acetyltransferase activity database_cross_reference “RHEA:79547”

diamine:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0019161`

Removed

diamine:2-oxoglutarate transaminase activity label “diamine transaminase activity”
diamine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: an alpha,omega-diamine + 2-oxoglutarate = an omega-aminoaldehyde + L-glutamate.”
- database_cross_reference “EC:2.6.1.29”

Added

diamine:2-oxoglutarate transaminase activity narrowMatch 23816
diamine:2-oxoglutarate transaminase activity narrowMatch 61624
diamine:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
diamine:2-oxoglutarate transaminase activity has_broad_synonym “diamine transaminase activity”
diamine:2-oxoglutarate transaminase activity label “diamine:2-oxoglutarate transaminase activity”
diamine:2-oxoglutarate transaminase activity database_cross_reference “RHEA:23816”
diamine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: an alpha,omega-diamine + 2-oxoglutarate = an omega-aminoaldehyde + L-glutamate.”
- database_cross_reference “RHEA:18217”
diamine:2-oxoglutarate transaminase activity database_cross_reference “RHEA:61624”

diaminopimelate transport `http://purl.obolibrary.org/obo/GO_0015830`

Removed

diaminopimelate transport definition “The directed movement of diaminopimelate, the anion of 2,6-diaminoheptanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

diaminopimelate transport definition “The directed movement of diaminopimelate, the anion of 2,6-diaminoheptanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

diaminopropionate ammonia-lyase activity `http://purl.obolibrary.org/obo/GO_0008838`

Removed

diaminopropionate ammonia-lyase activity definition “Catalysis of the reaction: 2,3-diaminopropionate + H2O = pyruvate + 2 NH3.”
- database_cross_reference “EC:4.3.1.15”

Added

diaminopropionate ammonia-lyase activity definition “Catalysis of the reaction: 2,3-diaminopropanoate + H2O + H+ = pyruvate + 2 NH4+.”
- database_cross_reference “EC:4.3.1.15”

dicarboxylate-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0047851`

Removed

dicarboxylate-CoA ligase activity SubClassOf acid-thiol ligase activity

Added

dicarboxylate-CoA ligase activity database_cross_reference “RHEA:40239”
dicarboxylate-CoA ligase activity narrowMatch 40291
dicarboxylate-CoA ligase activity narrowMatch 40239
dicarboxylate-CoA ligase activity narrowMatch 40287
dicarboxylate-CoA ligase activity database_cross_reference “RHEA:40295”
dicarboxylate-CoA ligase activity database_cross_reference “RHEA:40287”
dicarboxylate-CoA ligase activity narrowMatch 40295
dicarboxylate-CoA ligase activity narrowMatch 49600
dicarboxylate-CoA ligase activity database_cross_reference “RHEA:40291”
dicarboxylate-CoA ligase activity database_cross_reference “RHEA:49600”
dicarboxylate-CoA ligase activity SubClassOf CoA-ligase activity

digestive tract development `http://purl.obolibrary.org/obo/GO_0048565`

Removed

digestive tract development definition “The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.”
- database_cross_reference “GOC:go_curators”

Added

digestive tract development definition “The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.”
- database_cross_reference “GOC:curators”

digestive tract morphogenesis `http://purl.obolibrary.org/obo/GO_0048546`

Removed

digestive tract morphogenesis definition “The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:12618131”

Added

digestive tract morphogenesis definition “The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:12618131”

dihydroflavanol 4-reductase activity `http://purl.obolibrary.org/obo/GO_0045552`

Added

dihydroflavanol 4-reductase activity database_cross_reference “RHEA:23016”
dihydroflavanol 4-reductase activity narrowMatch 23016

dihydrolipoamide branched chain acyltransferase activity `http://purl.obolibrary.org/obo/GO_0043754`

Added

dihydrolipoyllysine-residue succinyltransferase activity `http://purl.obolibrary.org/obo/GO_0004149`

Removed

dihydrolipoyllysine-residue succinyltransferase activity database_cross_reference “Reactome:R-HSA-9858590”
- label “DLST transfers glutaryl to CoA”

dihydroorotate dehydrogenase (quinone) activity `http://purl.obolibrary.org/obo/GO_0106430`

Added

dihydropterin deaminase activity `http://purl.obolibrary.org/obo/GO_0004153`

Removed

dihydropterin deaminase activity definition “Catalysis of the reaction: 7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH3.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:19567870”
- database_cross_reference “PMID:38786926”

Added

dihydropterin deaminase activity definition “Catalysis of the reaction: 7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH4+.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:19567870”
- database_cross_reference “PMID:38786926”

dihydroxyphenylalanine:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0047309`

Removed

dihydroxyphenylalanine:2-oxoglutarate transaminase activity label “dihydroxyphenylalanine transaminase activity”
dihydroxyphenylalanine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + L-dopa = 3,4-dihydroxyphenylpyruvate + L-glutamate.”
- database_cross_reference “EC:2.6.1.49”
- database_cross_reference “RHEA:15273”
dihydroxyphenylalanine:2-oxoglutarate transaminase activity SubClassOf transaminase activity

Added

dihydroxyphenylalanine:2-oxoglutarate transaminase activity has_exact_synonym “dihydroxyphenylalanine transaminase activity”
dihydroxyphenylalanine:2-oxoglutarate transaminase activity label “dihydroxyphenylalanine:2-oxoglutarate transaminase activity”
dihydroxyphenylalanine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: L-dopa + 2-oxoglutarate = 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate.”
- database_cross_reference “RHEA:15273”
dihydroxyphenylalanine:2-oxoglutarate transaminase activity SubClassOf amino acid transaminase activity

diiodophenylpyruvate reductase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0047860`

Removed

diiodophenylpyruvate reductase (NAD+) activity has_related_synonym “aromatic alpha-keto acid”
- database_cross_reference “EC:1.1.1.96”
diiodophenylpyruvate reductase (NAD+) activity has_related_synonym “KAR”
- database_cross_reference “EC:1.1.1.96”
diiodophenylpyruvate reductase (NAD+) activity has_related_synonym “2-oxo acid reductase activity”
- database_cross_reference “EC:1.1.1.96”
diiodophenylpyruvate reductase (NAD+) activity exactMatch 1.1.1.96
diiodophenylpyruvate reductase (NAD+) activity has_related_synonym “3-(3,5-diiodo-4-hydroxyphenyl)lactate:NAD+ oxidoreductase activity”
- database_cross_reference “EC:1.1.1.96”
diiodophenylpyruvate reductase (NAD+) activity database_cross_reference “EC:1.1.1.96”

Added

diiodophenylpyruvate reductase (NAD+) activity term tracker item “https://github.com/geneontology/go-ontology/issues/31488”^^anyURI

dimethyl sulfoxide reductase activity `http://purl.obolibrary.org/obo/GO_0009389`

Removed

dimethyl sulfoxide reductase activity definition “Catalysis of the reaction: dimethyl sulfoxide + H+ = dimethyl sulfide + H2O.”
- database_cross_reference “PMID:8658134”
dimethyl sulfoxide reductase activity SubClassOf oxidoreductase activity, acting on a sulfur group of donors

Added

dimethyl sulfoxide reductase activity exactMatch DIMESULFREDUCT-RXN
dimethyl sulfoxide reductase activity has_exact_synonym “respiratory dimethylsulfoxide reductase”
- database_cross_reference “EC:1.8.5.3”
dimethyl sulfoxide reductase activity exactMatch 1.8.5.3
dimethyl sulfoxide reductase activity exactMatch 28494
dimethyl sulfoxide reductase activity database_cross_reference “RHEA:28494”
dimethyl sulfoxide reductase activity definition “Catalysis of the reaction: dimethyl sulfide + a menaquinone + H2O = dimethyl sulfoxide + a menaquinol.”
- database_cross_reference “PMID:8658134”
- database_cross_reference “RHEA:28494”
dimethyl sulfoxide reductase activity database_cross_reference “EC:1.8.5.3”
dimethyl sulfoxide reductase activity database_cross_reference “MetaCyc:DIMESULFREDUCT-RXN”
dimethyl sulfoxide reductase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31518”^^anyURI
dimethyl sulfoxide reductase activity SubClassOf oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor

disproportionation of elemental sulfur `http://purl.obolibrary.org/obo/GO_0019422`

Removed

disproportionation of elemental sulfur definition “The process in which sulfur compounds with an intermediate oxidation state serve as both electron donors and electron acceptors in an energy-generating redox process. The reaction takes place anaerobically, in light and in the absence of CO2.”
- database_cross_reference “MetaCyc:P203-PWY”

Added

disproportionation of elemental sulfur database_cross_reference “MetaCyc:PWY-5302”
disproportionation of elemental sulfur narrowMatch PWY-5302
disproportionation of elemental sulfur definition “The process in which sulfur compounds with an intermediate oxidation state serve as both electron donors and electron acceptors in an energy-generating redox process.”
- database_cross_reference “MetaCyc:P203-PWY”
disproportionation of elemental sulfur term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
disproportionation of elemental sulfur narrowMatch P203-PWY

dolichol-linked oligosaccharide biosynthetic process `http://purl.obolibrary.org/obo/GO_0006488`

Added

dolichol-linked oligosaccharide biosynthetic process database_cross_reference “Reactome:R-HSA-162699”
- label “Synthesis of dolichyl-phosphate mannose”

dolichyl diphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0006489`

Removed

dolichyl diphosphate biosynthetic process database_cross_reference “Reactome:R-HSA-446199”
- label “Synthesis of Dolichyl-phosphate”

dolichyl monophosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0043048`

Added

dolichyl monophosphate biosynthetic process database_cross_reference “Reactome:R-HSA-446199”
- label “Synthesis of dolichyl-phosphate”

dolichyl-diphosphooligosaccharide-protein glycotransferase activity `http://purl.obolibrary.org/obo/GO_0004579`

Added

dolichyl-diphosphooligosaccharide-protein glycotransferase activity database_cross_reference “Reactome:R-HSA-9931286”
- label “CD274 N-linked glycosylation in ER”
dolichyl-diphosphooligosaccharide-protein glycotransferase activity database_cross_reference “Reactome:R-HSA-9919011”
- label “Pre-NS1 folds and is N-glycosylated”
dolichyl-diphosphooligosaccharide-protein glycotransferase activity database_cross_reference “RHEA:50348”
dolichyl-diphosphooligosaccharide-protein glycotransferase activity database_cross_reference “Reactome:R-HSA-9918988”
- label “pre-M is N-glycosylated”
dolichyl-diphosphooligosaccharide-protein glycotransferase activity database_cross_reference “Reactome:R-HSA-9816276”
- label “CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum”
dolichyl-diphosphooligosaccharide-protein glycotransferase activity narrowMatch 50348
dolichyl-diphosphooligosaccharide-protein glycotransferase activity database_cross_reference “Reactome:R-HSA-9918962”
- label “E is N-glycosylated”

dolichyl-phosphate-mannose-protein mannosyltransferase activity `http://purl.obolibrary.org/obo/GO_0004169`

Added

dolichyl-phosphate-mannose-protein mannosyltransferase activity database_cross_reference “Reactome:R-HSA-9816277”
- label “CDH1 is O-manosylated”

dopachrome isomerase activity `http://purl.obolibrary.org/obo/GO_0004167`

Added

dopachrome isomerase activity database_cross_reference “Reactome:R-HSA-5662660”
- label “Dopachrome is transformed to DHICA by DCT”

dopamine loading into synaptic vesicle `http://purl.obolibrary.org/obo/GO_0160310`

Added

dopamine loading into synaptic vesicle has_obo_namespace “biological_process”
dopamine loading into synaptic vesicle created by “rynl”
dopamine loading into synaptic vesicle id “GO:0160310”
dopamine loading into synaptic vesicle definition “The active transport of dopamine neurotransmitters into a synaptic vesicle.”
- database_cross_reference “PMID:29666153”
dopamine loading into synaptic vesicle term tracker item “https://github.com/geneontology/go-ontology/issues/31143”^^anyURI
dopamine loading into synaptic vesicle label “dopamine loading into synaptic vesicle”
dopamine loading into synaptic vesicle creation date “2025-12-02T22:02:35Z”
Class: dopamine loading into synaptic vesicle
dopamine loading into synaptic vesicle SubClassOf aminergic neurotransmitter loading into synaptic vesicle
dopamine loading into synaptic vesicle SubClassOf dopamine transport

dorsal closure, leading edge cell fate determination `http://purl.obolibrary.org/obo/GO_0007393`

Removed

dorsal closure, leading edge cell fate determination definition “The cell fate determination process in which a cell within the dorsal ectoderm becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed.”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:12147138”

Added

dorsal closure, leading edge cell fate determination definition “The cell fate determination process in which a cell within the dorsal ectoderm becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:bf”
- database_cross_reference “PMID:12147138”

dorsal/ventral axis specification `http://purl.obolibrary.org/obo/GO_0009950`

Removed

dorsal/ventral axis specification definition “The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

dorsal/ventral axis specification definition “The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

dorsal/ventral pattern formation `http://purl.obolibrary.org/obo/GO_0009953`

Removed

dorsal/ventral pattern formation definition “The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:isa_complete”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

dorsal/ventral pattern formation definition “The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:isa_complete”
- database_cross_reference “GOC:tb”

double-stranded RNA adenosine deaminase activity `http://purl.obolibrary.org/obo/GO_0003726`

Removed

double-stranded RNA adenosine deaminase activity definition “Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule.”
- database_cross_reference “GOC:mah”
- database_cross_reference “RHEA:10120”

Added

double-stranded RNA adenosine deaminase activity definition “Catalysis of the reaction: adenosine + H2O = inosine + NH4+, in a double-stranded RNA molecule.”
- database_cross_reference “GOC:mah”
- database_cross_reference “RHEA:10120”

ecdysteroid biosynthetic process `http://purl.obolibrary.org/obo/GO_0045456`

Removed

ecdysteroid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development.”
- database_cross_reference “GOC:go_curators”

Added

ecdysteroid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development.”
- database_cross_reference “GOC:curators”

ecdysteroid secretion `http://purl.obolibrary.org/obo/GO_0045457`

Removed

ecdysteroid secretion definition “The regulated release of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development.”
- database_cross_reference “GOC:go_curators”

Added

ecdysteroid secretion definition “The regulated release of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development.”
- database_cross_reference “GOC:curators”

ectoderm formation `http://purl.obolibrary.org/obo/GO_0001705`

Removed

ectoderm formation definition “The formation of ectoderm during gastrulation.”
- database_cross_reference “GOC:go_curators”

Added

ectoderm formation definition “The formation of ectoderm during gastrulation.”
- database_cross_reference “GOC:curators”

ectodermal cell fate commitment `http://purl.obolibrary.org/obo/GO_0001712`

Removed

ectodermal cell fate commitment definition “The cell differentiation process that results in commitment of a cell to become part of the ectoderm.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0878932437”

Added

ectodermal cell fate commitment definition “The cell differentiation process that results in commitment of a cell to become part of the ectoderm.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0878932437”

ectodermal cell fate determination `http://purl.obolibrary.org/obo/GO_0001713`

Removed

ectodermal cell fate determination definition “The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an ectoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0878932437”

Added

ectodermal cell fate determination definition “The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an ectoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0878932437”

ectodermal cell fate specification `http://purl.obolibrary.org/obo/GO_0001715`

Removed

ectodermal cell fate specification definition “The cell fate determination process that results in a cell becoming becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.”
- database_cross_reference “GOC:go_curators”

Added

ectodermal cell fate specification definition “The cell fate determination process that results in a cell becoming becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.”
- database_cross_reference “GOC:curators”

egg coat `http://purl.obolibrary.org/obo/GO_0035805`

Added

egg coat term tracker item “https://github.com/geneontology/go-ontology/issues/31720”^^anyURI

electron transfer activity `http://purl.obolibrary.org/obo/GO_0009055`

Removed

electron transfer activity database_cross_reference “Reactome:R-HSA-2564826”
- label “4Fe-4S cluster assembles on NUBP2:NUBP1 scaffold”

embryo development `http://purl.obolibrary.org/obo/GO_0009790`

Removed

embryo development definition “The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.”
- database_cross_reference “GOC:isa_complete”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_sensu”

Added

embryo development definition “The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:isa_complete”
- database_cross_reference “GOC:mtg_sensu”

embryo development ending in birth or egg hatching `http://purl.obolibrary.org/obo/GO_0009792`

Removed

embryo development ending in birth or egg hatching definition “The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.”
- database_cross_reference “GOC:isa_complete”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_sensu”

Added

embryo development ending in birth or egg hatching definition “The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:isa_complete”
- database_cross_reference “GOC:mtg_sensu”

embryo development ending in seed dormancy `http://purl.obolibrary.org/obo/GO_0009793`

Removed

embryo development ending in seed dormancy definition “The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_sensu”

Added

embryo development ending in seed dormancy definition “The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_sensu”

embryonic axis specification `http://purl.obolibrary.org/obo/GO_0000578`

Removed

embryonic axis specification definition “The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:sdb_2009”

Added

embryonic axis specification definition “The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:sdb_2009”

embryonic development via the syncytial blastoderm `http://purl.obolibrary.org/obo/GO_0001700`

Removed

embryonic development via the syncytial blastoderm definition “The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_sensu”

Added

embryonic development via the syncytial blastoderm definition “The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_sensu”

embryonic digestive tract development `http://purl.obolibrary.org/obo/GO_0048566`

Removed

embryonic digestive tract development definition “The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus.”
- database_cross_reference “GOC:go_curators”

Added

embryonic digestive tract development definition “The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus.”
- database_cross_reference “GOC:curators”

embryonic digestive tract morphogenesis `http://purl.obolibrary.org/obo/GO_0048557`

Removed

embryonic digestive tract morphogenesis definition “The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed.”
- database_cross_reference “GOC:go_curators”

Added

embryonic digestive tract morphogenesis definition “The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed.”
- database_cross_reference “GOC:curators”

embryonic heart tube development `http://purl.obolibrary.org/obo/GO_0035050`

Removed

embryonic heart tube development definition “The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.”
- database_cross_reference “GOC:go_curators”

Added

embryonic heart tube development definition “The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.”
- database_cross_reference “GOC:curators”

embryonic pattern specification `http://purl.obolibrary.org/obo/GO_0009880`

Removed

embryonic pattern specification definition “The process that results in the patterns of cell differentiation that will arise in an embryo.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0521436125”

Added

embryonic pattern specification definition “The process that results in the patterns of cell differentiation that will arise in an embryo.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0521436125”

embryonic sheath `http://purl.obolibrary.org/obo/GO_0140400`

Added

embryonic sheath term tracker item “https://github.com/geneontology/go-ontology/issues/31680”^^anyURI
embryonic sheath definition “A specialized, transient apical extracellular matrix (aECM) that overlays the apical surface of the embryonic epidermis in Caenorhabditis elegans. It is secreted just prior to the start of embryonic elongation and acts as a mechanical scaffold to maintain embryonic integrity, distribute actomyosin-dependent stress, and anchor developing muscles.”
- database_cross_reference “PMID:28526752”
- database_cross_reference “PMID:33036165”
- database_cross_reference “PMID:22278925”
- database_cross_reference “PMID:25798732”
embryonic sheath creation date “2026-03-06T09:07:34Z”
embryonic sheath id “GO:0140400”
embryonic sheath label “embryonic sheath”
embryonic sheath has_obo_namespace “cellular_component”
embryonic sheath created by “pg”
Class: embryonic sheath
embryonic sheath SubClassOf specialized extracellular matrix

endocytic vesicle `http://purl.obolibrary.org/obo/GO_0030139`

Removed

endocytic vesicle definition “A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:19696797”

Added

endocytic vesicle definition “A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:19696797”

endoderm formation `http://purl.obolibrary.org/obo/GO_0001706`

Removed

endoderm formation definition “The formation of the endoderm during gastrulation.”
- database_cross_reference “GOC:go_curators”

Added

endoderm formation definition “The formation of the endoderm during gastrulation.”
- database_cross_reference “GOC:curators”

endodermal cell fate commitment `http://purl.obolibrary.org/obo/GO_0001711`

Removed

endodermal cell fate commitment definition “The cell differentiation process that results in commitment of a cell to become part of the endoderm.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0878932437”

Added

endodermal cell fate commitment definition “The cell differentiation process that results in commitment of a cell to become part of the endoderm.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0878932437”

endodermal cell fate determination `http://purl.obolibrary.org/obo/GO_0007493`

Removed

endodermal cell fate determination definition “The cell fate determination process in which a cell becomes capable of differentiating autonomously into an endoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0878932437”

Added

endodermal cell fate determination definition “The cell fate determination process in which a cell becomes capable of differentiating autonomously into an endoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0878932437”

endodermal cell fate specification `http://purl.obolibrary.org/obo/GO_0001714`

Removed

endodermal cell fate specification definition “The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.”
- database_cross_reference “GOC:go_curators”

Added

endodermal cell fate specification definition “The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.”
- database_cross_reference “GOC:curators”

endoglycosylceramidase activity `http://purl.obolibrary.org/obo/GO_0047876`

Added

endoglycosylceramidase activity database_cross_reference “RHEA:65556”
endoglycosylceramidase activity database_cross_reference “RHEA:65552”
endoglycosylceramidase activity narrowMatch 65544
endoglycosylceramidase activity database_cross_reference “RHEA:65544”
endoglycosylceramidase activity narrowMatch 65552
endoglycosylceramidase activity narrowMatch 65556
endoglycosylceramidase activity narrowMatch 65548
endoglycosylceramidase activity narrowMatch 65540
endoglycosylceramidase activity database_cross_reference “RHEA:65540”
endoglycosylceramidase activity database_cross_reference “RHEA:65548”

endonuclease activity `http://purl.obolibrary.org/obo/GO_0004519`

Added

endonuclease activity database_cross_reference “Reactome:R-HSA-9970282”
- label “U1 snRNP suppresses CPSF3-mediated pre-mRNA cleavage at intronic PAS”
endonuclease activity database_cross_reference “Reactome:R-HSA-9970193”
- label “CPSF3 cleaves pre-mRNA at distal 3’UTR PAS”
endonuclease activity database_cross_reference “Reactome:R-HSA-9970294”
- label “CPSF3 cleaves pre-mRNA at proximal 3’UTR PAS”

endopeptidase activity `http://purl.obolibrary.org/obo/GO_0004175`

Removed

endopeptidase activity database_cross_reference “Reactome:R-HSA-450466”
- label “AUF1:mRNA complex is destroyed”

Added

endopeptidase activity database_cross_reference “Reactome:R-HSA-450466”
- label “AUF1:mRNA complex is degraded”
endopeptidase activity database_cross_reference “Reactome:R-HSA-9929486”
- label “SPOP-mediated degradation of CD274 by 26S Proteosome”
endopeptidase activity database_cross_reference “Reactome:R-HSA-9912636”
- label “Proteasomal cleavage of intracellular substrate (PA28-alpha-beta-20S proteasome catalyst)”
endopeptidase activity database_cross_reference “Reactome:R-HSA-9934884”
- label “Proteolysis of K48polyUb,p-S-CRY1,2”
endopeptidase activity database_cross_reference “Reactome:R-HSA-9912747”
- label “Proteasomal clevage of exogenous antigen (immunoproteasome catalyst)”
endopeptidase activity database_cross_reference “Reactome:R-HSA-9931314”
- label “Proteasomal degradation of polyUb-p-S195-CD274”
endopeptidase activity database_cross_reference “Reactome:R-HSA-9934887”
- label “Proteolysis of K48polyUb-K107,p-S-CRY1,K48polyUb-K126,p-S-CRY2”
endopeptidase activity database_cross_reference “Reactome:R-HSA-9949676”
- label “The proteasome degrades the alanine-tailed K48-polyUb nascent peptide bound to LTN1:NEMF:TCF25:VCP hexamer”
endopeptidase activity database_cross_reference “Reactome:R-HSA-9934893”
- label “Proteolysis of K48polyUb-K,p-S-PER1,2,3”
endopeptidase activity database_cross_reference “Reactome:R-HSA-9760521”
- label “Unknown peptidase cleaves pro-STa”
endopeptidase activity database_cross_reference “Reactome:R-HSA-9954728”
- label “The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide”
endopeptidase activity database_cross_reference “Reactome:R-HSA-9912751”
- label “Proteasomal cleavage of partially digested antigen (immunoproteasome catalyst)”
endopeptidase activity database_cross_reference “Reactome:R-HSA-9929352”
- label “Ubiquitinated CD274 is degraded by the 26S proteasome”
endopeptidase activity database_cross_reference “Reactome:R-HSA-9912655”
- label “Proteasomal cleavage of intracellular substrate (immunoproteasome catalyst)”
endopeptidase activity database_cross_reference “Reactome:R-HSA-9766223”
- label “Proteasome-dependent degradation of ubiquitinated CDH1”

endoplasmic reticulum to Golgi vesicle-mediated transport `http://purl.obolibrary.org/obo/GO_0006888`

Added

endoplasmic reticulum to Golgi vesicle-mediated transport SubClassOf intercellular transport

endoplasmic reticulum to chloroplast transport `http://purl.obolibrary.org/obo/GO_1901965`

Added

endoplasmic reticulum to chloroplast transport SubClassOf intercellular transport

endoplasmic reticulum to cytosol auxin transport `http://purl.obolibrary.org/obo/GO_0080162`

Added

endoplasmic reticulum to cytosol auxin transport SubClassOf intercellular transport

endoplasmic reticulum to cytosol transport `http://purl.obolibrary.org/obo/GO_1903513`

Added

endoplasmic reticulum to cytosol transport SubClassOf intercellular transport

endoplasmic reticulum-lipid droplet tether activity `http://purl.obolibrary.org/obo/GO_0170007`

Added

endoplasmic reticulum-lipid droplet tether activity database_cross_reference “Reactome:R-HSA-9942190”
- label “FITM1 binds TAGs”
endoplasmic reticulum-lipid droplet tether activity database_cross_reference “Reactome:R-HSA-8857686”
- label “FITM2 binds TAGs”

endoplasmic reticulum-lysosome membrane contact site `http://purl.obolibrary.org/obo/GO_7770052`

Added

endoplasmic reticulum-lysosome membrane contact site created by “dragon-ai-agent”
endoplasmic reticulum-lysosome membrane contact site term tracker item “https://github.com/geneontology/go-ontology/issues/31541”^^anyURI
endoplasmic reticulum-lysosome membrane contact site definition “An organelle membrane contact site between the endoplasmic reticulum membrane and the lysosomal membrane.”
- database_cross_reference “PMID:31537798”
- database_cross_reference “PMID:39370902”
endoplasmic reticulum-lysosome membrane contact site has_exact_synonym “lysosome-ER membrane contact site”
endoplasmic reticulum-lysosome membrane contact site label “endoplasmic reticulum-lysosome membrane contact site”
endoplasmic reticulum-lysosome membrane contact site has_obo_namespace “cellular_component”
endoplasmic reticulum-lysosome membrane contact site id “GO:7770052”
endoplasmic reticulum-lysosome membrane contact site creation date “2026-02-12T00:09:12Z”
endoplasmic reticulum-lysosome membrane contact site has_exact_synonym “ER-lysosome contact site”
endoplasmic reticulum-lysosome membrane contact site has_exact_synonym “ER-lysosome MCS”
Class: endoplasmic reticulum-lysosome membrane contact site
endoplasmic reticulum-lysosome membrane contact site SubClassOf endoplasmic reticulum-vacuole membrane contact site

endosomal lumen acidification `http://purl.obolibrary.org/obo/GO_0048388`

Removed

endosomal lumen acidification definition “Any process that reduces the pH of the endosomal lumen, measured by the concentration of the hydrogen ion.”
- database_cross_reference “GOC:jid”

Added

endosomal lumen acidification definition “Any process that reduces the pH of the endosomal lumen, corresponding to an increase in hydrogen ion concentration.”
- database_cross_reference “GOC:jid”

endosome to lysosome transport `http://purl.obolibrary.org/obo/GO_0008333`

Added

endosome to lysosome transport SubClassOf intercellular transport

endosome to pigment granule transport `http://purl.obolibrary.org/obo/GO_0043485`

Added

endosome to pigment granule transport SubClassOf intercellular transport

endospore external encapsulating structure `http://purl.obolibrary.org/obo/GO_0043591`

Removed

endospore external encapsulating structure definition “The structures that lie outside the inner membrane and surround the entire endospore; consists of a peptidoglycan-containing inner layer (the endospore cortex) surrounded by a multilayered proteinaceous coat. An exosporium may be present as an extreme outer layer.”
- database_cross_reference “PMID:15035041”
- database_cross_reference “GOC:go_curators”

Added

endospore external encapsulating structure definition “The structures that lie outside the inner membrane and surround the entire endospore; consists of a peptidoglycan-containing inner layer (the endospore cortex) surrounded by a multilayered proteinaceous coat. An exosporium may be present as an extreme outer layer.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:15035041”

endothelial cell differentiation `http://purl.obolibrary.org/obo/GO_0045446`

Removed

endothelial cell differentiation definition “The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “CL:0000115”

Added

endothelial cell differentiation definition “The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.”
- database_cross_reference “GOC:curators”
- database_cross_reference “CL:0000115”

endothelial cell migration `http://purl.obolibrary.org/obo/GO_0043542`

Removed

endothelial cell migration definition “The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.”
- database_cross_reference “GOC:go_curators”

Added

endothelial cell migration definition “The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.”
- database_cross_reference “GOC:curators”

energy transducer activity `http://purl.obolibrary.org/obo/GO_0031992`

Removed

energy transducer activity definition “The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell.”
- database_cross_reference “GOC:go_curators”

Added

energy transducer activity definition “The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell.”
- database_cross_reference “GOC:curators”

enoyl-[acyl-carrier-protein] reductase (NADPH) activity `http://purl.obolibrary.org/obo/GO_0141148`

Added

ent-kaurene biosynthetic process `http://purl.obolibrary.org/obo/GO_0033332`

Added

ent-kaurene biosynthetic process narrowMatch PWY-5032
ent-kaurene biosynthetic process database_cross_reference “MetaCyc:PWY-6653”
ent-kaurene biosynthetic process narrowMatch PWY-6653
ent-kaurene biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI

enterobactin biosynthetic process `http://purl.obolibrary.org/obo/GO_0009239`

Removed

enterobactin biosynthetic process definition “The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N’,N’,N’’-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway.”
- database_cross_reference “GOC:go_curators”

Added

enterobactin biosynthetic process definition “The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N’,N’,N’’-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway.”
- database_cross_reference “GOC:curators”

enterobactin transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0042931`

Added

enterobactin transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9911600”
- label “Efflux pump complexes transport enterobactin from periplasmic space to extracellular region”
enterobactin transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9911595”
- label “EntS transports enterobactin from cytosol to periplasmic space”

enterochelin esterase activity `http://purl.obolibrary.org/obo/GO_0008849`

Added

enterochelin esterase activity database_cross_reference “Reactome:R-HSA-9911599”
- label “Fes hydrolyses ferrienterobactin to DHBS”

enucleate erythrocyte differentiation `http://purl.obolibrary.org/obo/GO_0043353`

Removed

enucleate erythrocyte differentiation definition “The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus.”
- database_cross_reference “GOC:go_curators”

Added

enucleate erythrocyte differentiation definition “The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus.”
- database_cross_reference “GOC:curators”

enucleate erythrocyte maturation `http://purl.obolibrary.org/obo/GO_0043354`

Removed

enucleate erythrocyte maturation definition “A developmental process, independent of morphogenetic (shape) change, that is required for an enucleate erythrocyte to attain its fully functional state. An enucleate erythrocyte is an erythrocyte without a nucleus.”
- database_cross_reference “GOC:go_curators”

Added

enucleate erythrocyte maturation definition “A developmental process, independent of morphogenetic (shape) change, that is required for an enucleate erythrocyte to attain its fully functional state. An enucleate erythrocyte is an erythrocyte without a nucleus.”
- database_cross_reference “GOC:curators”

enzyme activator activity `http://purl.obolibrary.org/obo/GO_0008047`

Added

enzyme activator activity database_cross_reference “Reactome:R-HSA-9948070”
- label “POMGNT1 catalyzes FKRP:FKTN:RXYLT1 formation”

enzyme inhibitor activity `http://purl.obolibrary.org/obo/GO_0004857`

Added

enzyme inhibitor activity database_cross_reference “Reactome:R-HSA-1614336”
- label “SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases”
enzyme inhibitor activity database_cross_reference “Reactome:R-HSA-1474158”
- label “GCHFR binds to GCH1 and negatively regulates its activity”

enzyme-substrate adaptor activity `http://purl.obolibrary.org/obo/GO_0140767`

Added

enzyme-substrate adaptor activity database_cross_reference “Reactome:R-HSA-5653886”
- label “B4GALT1 binds LALBA”

epidermal cell differentiation `http://purl.obolibrary.org/obo/GO_0009913`

Removed

epidermal cell differentiation definition “The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_sensu”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:sdb_2009”

Added

epidermal cell differentiation definition “The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_sensu”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:sdb_2009”

epidermis development `http://purl.obolibrary.org/obo/GO_0008544`

Removed

epidermis development definition “The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “UBERON:0001003”

Added

epidermis development definition “The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.”
- database_cross_reference “GOC:curators”
- database_cross_reference “UBERON:0001003”

epigenetic programming of gene expression `http://purl.obolibrary.org/obo/GO_0043045`

Removed

epigenetic programming of gene expression definition “A epigenetic process that happens during embryonic development that modulates gene expression potential at later stages of development of the organism, including the adult. Epigenetic regulation takes place via chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine DNA methylation.”
- database_cross_reference “PMID:12138111”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:22868271”

Added

epigenetic programming of gene expression definition “A epigenetic process that happens during embryonic development that modulates gene expression potential at later stages of development of the organism, including the adult. Epigenetic regulation takes place via chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine DNA methylation.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:12138111”
- database_cross_reference “PMID:22868271”

epiplastidial membrane `http://purl.obolibrary.org/obo/GO_7770040`

Added

epiplastidial membrane creation date “2026-01-29T01:11:34Z”
epiplastidial membrane has_exact_synonym “EpM”
epiplastidial membrane has_exact_synonym “EPrER”
epiplastidial membrane has_exact_synonym “cERM”
epiplastidial membrane label “epiplastidial membrane”
epiplastidial membrane id “GO:7770040”
epiplastidial membrane created by “dragon-ai-agent”
epiplastidial membrane has_obo_namespace “cellular_component”
epiplastidial membrane has_exact_synonym “epiplastid rough ER”
epiplastidial membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31421”^^anyURI
epiplastidial membrane has_exact_synonym “chloroplast ER membrane”
epiplastidial membrane definition “The outermost lipid bilayer surrounding complex plastids in organisms that acquired their plastids through secondary endosymbiosis. This membrane is derived from the host cell’s endomembrane system and is continuous with the rough endoplasmic reticulum and the outer nuclear envelope. In some species, the cytoplasmic face may be studded with ribosomes.”
- database_cross_reference “PMID:39383259”
- database_cross_reference “PMID:27179349”
- database_cross_reference “PMID:15937721”
Class: epiplastidial membrane
epiplastidial membrane SubClassOf plastid membrane

epoxide hydrolase activity `http://purl.obolibrary.org/obo/GO_0004301`

Added

epoxide hydrolase activity database_cross_reference “RHEA:44048”
epoxide hydrolase activity database_cross_reference “RHEA:80783”
epoxide hydrolase activity narrowMatch 80779
epoxide hydrolase activity database_cross_reference “RHEA:80791”
epoxide hydrolase activity database_cross_reference “RHEA:80779”
epoxide hydrolase activity database_cross_reference “RHEA:44044”
epoxide hydrolase activity database_cross_reference “RHEA:80799”
epoxide hydrolase activity database_cross_reference “RHEA:45352”
epoxide hydrolase activity narrowMatch 44048
epoxide hydrolase activity database_cross_reference “RHEA:44032”
epoxide hydrolase activity database_cross_reference “RHEA:80591”
epoxide hydrolase activity database_cross_reference “RHEA:44036”
epoxide hydrolase activity narrowMatch 81855
epoxide hydrolase activity narrowMatch 44036
epoxide hydrolase activity narrowMatch 56584
epoxide hydrolase activity narrowMatch 80791
epoxide hydrolase activity narrowMatch 80795
epoxide hydrolase activity database_cross_reference “RHEA:81855”
epoxide hydrolase activity narrowMatch 44044
epoxide hydrolase activity database_cross_reference “RHEA:80787”
epoxide hydrolase activity narrowMatch 45352
epoxide hydrolase activity narrowMatch 80783
epoxide hydrolase activity narrowMatch 80787
epoxide hydrolase activity database_cross_reference “RHEA:80795”
epoxide hydrolase activity database_cross_reference “RHEA:44040”
epoxide hydrolase activity narrowMatch 80591
epoxide hydrolase activity narrowMatch 44032
epoxide hydrolase activity database_cross_reference “RHEA:56584”
epoxide hydrolase activity narrowMatch 44040
epoxide hydrolase activity narrowMatch 80799

erythro-3-hydroxyaspartate ammonia-lyase activity `http://purl.obolibrary.org/obo/GO_0047447`

Removed

erythro-3-hydroxyaspartate ammonia-lyase activity definition “Catalysis of the reaction: erythro-3-hydroxy-L-aspartate = NH3 + oxaloacetic acid.”
- database_cross_reference “MetaCyc:4.3.1.20-RXN”
- database_cross_reference “EC:4.3.1.20”

Added

erythro-3-hydroxyaspartate ammonia-lyase activity definition “Catalysis of the reaction: 3-hydroxy-L-aspartate = oxaloacetate + NH4+.”
- database_cross_reference “RHEA:19757”

estradiol 17-beta-dehydrogenase [NAD(P)+] activity `http://purl.obolibrary.org/obo/GO_0004303`

Removed

estradiol 17-beta-dehydrogenase [NAD(P)+] activity database_cross_reference “Reactome:R-HSA-8862137”
- label “HSD17B2 oxidises estradiol (E2) to estrone (E1)”
estradiol 17-beta-dehydrogenase [NAD(P)+] activity database_cross_reference “Reactome:R-HSA-6810594”
- label “HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1)”

Added

estradiol 17-beta-dehydrogenase [NAD(P)+] activity database_cross_reference “Reactome:R-HSA-8862137”
- label “HSD17B2 oxidises estradiol (EST17b) to estrone (E1)”
estradiol 17-beta-dehydrogenase [NAD(P)+] activity database_cross_reference “Reactome:R-HSA-6810594”
- label “HSD17B14 tetramer oxidises estradiol (EST17b) to estrone (E1)”

ethanolamine ammonia-lyase activity `http://purl.obolibrary.org/obo/GO_0008851`

Removed

ethanolamine ammonia-lyase activity definition “Catalysis of the reaction: ethanolamine = acetaldehyde + NH3.”
- database_cross_reference “EC:4.3.1.7”

Added

ethanolamine ammonia-lyase activity definition “Catalysis of the reaction: ethanolamine = acetaldehyde + NH4+.”
- database_cross_reference “RHEA:15313”

ethanolamine oxidase activity `http://purl.obolibrary.org/obo/GO_0047883`

Removed

ethanolamine oxidase activity definition “Catalysis of the reaction: ethanolamine + H2O + O2 = glycolaldehyde + NH3 + H2O2.”
- database_cross_reference “RHEA:18581”

Added

ethanolamine oxidase activity definition “Catalysis of the reaction: ethanolamine + O2 + H2O = glycolaldehyde + H2O2 + NH4+.”
- database_cross_reference “RHEA:18581”

ethanolaminephosphotransferase activity `http://purl.obolibrary.org/obo/GO_0004307`

Added

ethanolaminephosphotransferase activity narrowMatch 80247
ethanolaminephosphotransferase activity database_cross_reference “RHEA:54248”
ethanolaminephosphotransferase activity database_cross_reference “RHEA:54340”
ethanolaminephosphotransferase activity narrowMatch 54252
ethanolaminephosphotransferase activity narrowMatch 54248
ethanolaminephosphotransferase activity database_cross_reference “RHEA:80247”
ethanolaminephosphotransferase activity database_cross_reference “RHEA:54252”
ethanolaminephosphotransferase activity narrowMatch 54340

ethylene biosynthetic process `http://purl.obolibrary.org/obo/GO_0009693`

Added

ethylene biosynthetic process database_cross_reference “MetaCyc:PWY-6853”
ethylene biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
ethylene biosynthetic process narrowMatch PWY-6853
ethylene biosynthetic process narrowMatch ETHYL-PWY
ethylene biosynthetic process database_cross_reference “MetaCyc:PWY-6854”
ethylene biosynthetic process narrowMatch PWY-6854

exosporium `http://purl.obolibrary.org/obo/GO_0043592`

Removed

exosporium SubClassOf part of some endospore external encapsulating structure

Added

exosporium SubClassOf part of some cell wall

export from the mitochondrion `http://purl.obolibrary.org/obo/GO_0170037`

Added

export from the mitochondrion SubClassOf intercellular transport

external encapsulating structure `http://purl.obolibrary.org/obo/GO_0030312`

Removed

external encapsulating structure definition “A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space.”
- database_cross_reference “GOC:go_curators”
external encapsulating structure SubClassOf part of some cell periphery

Added

external encapsulating structure definition “A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space.”
- database_cross_reference “GOC:curators”
external encapsulating structure term tracker item “https://github.com/geneontology/go-ontology/issues/31720”^^anyURI
external encapsulating structure SubClassOf part of some extracellular region

external side of apical plasma membrane `http://purl.obolibrary.org/obo/GO_0098591`

Removed

external side of apical plasma membrane definition “The leaflet the apical region of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:ab”

Added

external side of apical plasma membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
external side of apical plasma membrane definition “The leaflet the apical region of the plasma membrane that faces the extracellular side of the cell, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:ab”

external side of cell outer membrane `http://purl.obolibrary.org/obo/GO_0031240`

Removed

external side of cell outer membrane definition “The side of the outer membrane that is opposite to the side that faces the periplasm of the cell.”
- database_cross_reference “GOC:mtg_sensu”
- database_cross_reference “GOC:mlg”

Added

external side of cell outer membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
external side of cell outer membrane definition “The leaflet of the outer membrane that is opposite to the side that faces the periplasm of the cell, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:mtg_sensu”
- database_cross_reference “GOC:mlg”

external side of mycolate outer membrane `http://purl.obolibrary.org/obo/GO_0098568`

Removed

external side of mycolate outer membrane definition “The side (leaflet) of the mycolate outer membrane that faces the environment and any proteins embedded in it or loosely bound to its surface.”
- database_cross_reference “GOC:dos”
- database_cross_reference “PMID:18316738”
- database_cross_reference “PMID:18567661”

Added

external side of mycolate outer membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
external side of mycolate outer membrane definition “The leaflet of the mycolate outer membrane that faces the periplasm of the cell, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:dos”
- database_cross_reference “PMID:18316738”
- database_cross_reference “PMID:18567661”

external side of plasma membrane `http://purl.obolibrary.org/obo/GO_0009897`

Removed

external side of plasma membrane definition “The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:tb”

Added

external side of plasma membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
external side of plasma membrane definition “The leaflet of the plasma membrane that faces the extracellular side of the cell, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:tb”

extracellular ammonia-gated monoatomic ion channel activity `http://purl.obolibrary.org/obo/GO_0036081`

Removed

extracellular ammonia-gated monoatomic ion channel activity definition “Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts.”
- database_cross_reference “GOC:sart”
- database_cross_reference “PMID:19135896”

Added

extracellular ammonia-gated monoatomic ion channel activity definition “Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH4+) has been bound by the channel complex or one of its constituent parts.”
- database_cross_reference “GOC:sart”
- database_cross_reference “PMID:19135896”

extracellular exosome `http://purl.obolibrary.org/obo/GO_0070062`

Removed

extracellular exosome SubClassOf part of some obsolete extracellular space

extracellular exosome complex `http://purl.obolibrary.org/obo/GO_1990563`

Removed

extracellular exosome complex SubClassOf protein-containing complex

Added

extracellular exosome complex SubClassOf extracellular protein-containing complex

extracellular isoamylase complex `http://purl.obolibrary.org/obo/GO_0010367`

Removed

extracellular isoamylase complex EquivalentTo isoamylase complex and (part of some extracellular region)
extracellular isoamylase complex SubClassOf part of some extracellular region
extracellular isoamylase complex SubClassOf isoamylase complex

Added

extracellular isoamylase complex SubClassOf extracellular protein-containing complex

extracellular protein-containing complex `http://purl.obolibrary.org/obo/GO_0140392`

Added

extracellular protein-containing complex creation date “2020-09-09T05:12:38Z”
extracellular protein-containing complex id “GO:0140392”
extracellular protein-containing complex created by “pg”
extracellular protein-containing complex has_broad_synonym “extracellular protein complex”
extracellular protein-containing complex term tracker item “https://github.com/geneontology/go-ontology/issues/31673”^^anyURI
extracellular protein-containing complex definition “A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together outside a cell.”
- database_cross_reference “GOC:curators”
extracellular protein-containing complex has_obo_namespace “cellular_component”
extracellular protein-containing complex label “extracellular protein-containing complex”
extracellular protein-containing complex in_subset gocheck_do_not_annotate
Class: extracellular protein-containing complex
extracellular protein-containing complex EquivalentTo protein-containing complex and (part of some extracellular region)
extracellular protein-containing complex SubClassOf part of some extracellular region
extracellular protein-containing complex SubClassOf protein-containing complex

extracellular region `http://purl.obolibrary.org/obo/GO_0005576`

Removed

extracellular region definition “The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.”
- database_cross_reference “GOC:go_curators”

Added

extracellular region definition “The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.”
- database_cross_reference “GOC:curators”
extracellular region in_subset goslim_drosophila

extracellular transport `http://purl.obolibrary.org/obo/GO_0006858`

Removed

extracellular transport definition “The transport of substances that occurs outside cells.”
- database_cross_reference “GOC:go_curators”

Added

extracellular transport definition “The transport of substances that occurs outside cells.”
- database_cross_reference “GOC:curators”

extracellularly ATP-gated monoatomic cation channel activity `http://purl.obolibrary.org/obo/GO_0004931`

Added

extracellularly ATP-gated monoatomic cation channel activity database_cross_reference “Reactome:R-HSA-9905964”
- label “P2RX7 in ATP:P2RX7:PANX1 transports cations from the extracellular region to the cytosol”

eye photoreceptor cell differentiation `http://purl.obolibrary.org/obo/GO_0001754`

Removed

eye photoreceptor cell differentiation definition “The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms.”
- database_cross_reference “GOC:go_curators”

Added

eye photoreceptor cell differentiation definition “The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms.”
- database_cross_reference “GOC:curators”

farnesol catabolic process `http://purl.obolibrary.org/obo/GO_0016488`

Removed

farnesol catabolic process definition “The chemical reactions and pathways resulting in the breakdown of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol.”
- database_cross_reference “GOC:go_curators”

Added

farnesol catabolic process definition “The chemical reactions and pathways resulting in the breakdown of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol.”
- database_cross_reference “GOC:curators”

farnesol metabolic process `http://purl.obolibrary.org/obo/GO_0016487`

Removed

farnesol metabolic process definition “The chemical reactions and pathways involving the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol.”
- database_cross_reference “GOC:go_curators”

Added

farnesol metabolic process definition “The chemical reactions and pathways involving the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol.”
- database_cross_reference “GOC:curators”

farnesyl diphosphate catabolic process `http://purl.obolibrary.org/obo/GO_0045339`

Removed

farnesyl diphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of farnesyl diphosphate.”
- database_cross_reference “GOC:go_curators”

Added

farnesyl diphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of farnesyl diphosphate.”
- database_cross_reference “GOC:curators”

farnesyl diphosphate metabolic process `http://purl.obolibrary.org/obo/GO_0045338`

Removed

farnesyl diphosphate metabolic process definition “The chemical reactions and pathways involving farnesyl diphosphate, an intermediate in carotenoid, sesquiterpene, squalene and sterol biosynthesis, as well as a substrate in protein farnesylation.”
- database_cross_reference “GOC:go_curators”

Added

farnesyl diphosphate metabolic process definition “The chemical reactions and pathways involving farnesyl diphosphate, an intermediate in carotenoid, sesquiterpene, squalene and sterol biosynthesis, as well as a substrate in protein farnesylation.”
- database_cross_reference “GOC:curators”

farnesylcysteine lyase activity `http://purl.obolibrary.org/obo/GO_0102149`

Removed

farnesylcysteine lyase activity definition “Catalysis of the reaction: S-[(2E,6E)-farnesyl]-L-cysteine + O2 + H2O = (2-trans,6-trans)-farnesal + L-cysteine + hydrogen peroxide.”
- database_cross_reference “GOC:pz”
- database_cross_reference “EC:1.8.3.6”

Added

farnesylcysteine lyase activity definition “Catalysis of the reaction: S-[(2E,6E)-farnesyl]-L-cysteine + O2 + H2O = (2-trans,6-trans)-farnesal + L-cysteine + H2O2.”
- database_cross_reference “GOC:pz”
- database_cross_reference “EC:1.8.3.6”

fat cell differentiation `http://purl.obolibrary.org/obo/GO_0045444`

Removed

fat cell differentiation definition “The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “CL:0000136”

Added

fat cell differentiation definition “The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.”
- database_cross_reference “GOC:curators”
- database_cross_reference “CL:0000136”

fat-soluble vitamin biosynthetic process `http://purl.obolibrary.org/obo/GO_0042362`

Added

fat-soluble vitamin biosynthetic process database_cross_reference “Reactome:R-HSA-6806667”
- label “Metabolism of fat-soluble vitamins”

fatty acid alpha-dioxygenase activity `http://purl.obolibrary.org/obo/GO_0102672`

Added

fatty acid alpha-dioxygenase activity database_cross_reference “RHEA:63860”
fatty acid alpha-dioxygenase activity database_cross_reference “RHEA:63836”
fatty acid alpha-dioxygenase activity narrowMatch 63864
fatty acid alpha-dioxygenase activity database_cross_reference “RHEA:63864”
fatty acid alpha-dioxygenase activity database_cross_reference “RHEA:63852”
fatty acid alpha-dioxygenase activity narrowMatch 63856
fatty acid alpha-dioxygenase activity narrowMatch 63836
fatty acid alpha-dioxygenase activity narrowMatch 16329
fatty acid alpha-dioxygenase activity narrowMatch 63852
fatty acid alpha-dioxygenase activity database_cross_reference “RHEA:63868”
fatty acid alpha-dioxygenase activity narrowMatch 63868
fatty acid alpha-dioxygenase activity database_cross_reference “RHEA:63856”
fatty acid alpha-dioxygenase activity database_cross_reference “RHEA:16329”
fatty acid alpha-dioxygenase activity narrowMatch 63860

fatty acid catabolic process `http://purl.obolibrary.org/obo/GO_0009062`

Removed

fatty acid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.”
- database_cross_reference “GOC:go_curators”

Added

fatty acid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.”
- database_cross_reference “GOC:curators”

fatty acid elongase activity `http://purl.obolibrary.org/obo/GO_0009922`

Added

fatty acid elongase activity database_cross_reference “RHEA:36843”
fatty acid elongase activity database_cross_reference “RHEA:36915”
fatty acid elongase activity database_cross_reference “RHEA:36875”
fatty acid elongase activity narrowMatch 36843
fatty acid elongase activity narrowMatch 36519
fatty acid elongase activity database_cross_reference “RHEA:36911”
fatty acid elongase activity narrowMatch 36947
fatty acid elongase activity narrowMatch 36819
fatty acid elongase activity narrowMatch 36927
fatty acid elongase activity narrowMatch 36851
fatty acid elongase activity narrowMatch 36859
fatty acid elongase activity narrowMatch 36983
fatty acid elongase activity narrowMatch 39291
fatty acid elongase activity database_cross_reference “RHEA:36923”
fatty acid elongase activity database_cross_reference “RHEA:36819”
fatty acid elongase activity database_cross_reference “RHEA:36995”
fatty acid elongase activity narrowMatch 36911
fatty acid elongase activity narrowMatch 36919
fatty acid elongase activity narrowMatch 36995
fatty acid elongase activity narrowMatch 36979
fatty acid elongase activity narrowMatch 85827
fatty acid elongase activity database_cross_reference “RHEA:36979”
fatty acid elongase activity database_cross_reference “RHEA:36967”
fatty acid elongase activity narrowMatch 36967
fatty acid elongase activity database_cross_reference “RHEA:36927”
fatty acid elongase activity narrowMatch 37243
fatty acid elongase activity database_cross_reference “RHEA:36807”
fatty acid elongase activity narrowMatch 36531
fatty acid elongase activity database_cross_reference “RHEA:85827”
fatty acid elongase activity database_cross_reference “RHEA:36851”
fatty acid elongase activity narrowMatch 36907
fatty acid elongase activity narrowMatch 36875
fatty acid elongase activity database_cross_reference “RHEA:37095”
fatty acid elongase activity database_cross_reference “RHEA:36983”
fatty acid elongase activity database_cross_reference “RHEA:36515”
fatty acid elongase activity narrowMatch 36915
fatty acid elongase activity database_cross_reference “RHEA:36963”
fatty acid elongase activity database_cross_reference “RHEA:39291”
fatty acid elongase activity database_cross_reference “RHEA:36859”
fatty acid elongase activity narrowMatch 36871
fatty acid elongase activity narrowMatch 37095
fatty acid elongase activity database_cross_reference “RHEA:36871”
fatty acid elongase activity database_cross_reference “RHEA:36907”
fatty acid elongase activity database_cross_reference “RHEA:36531”
fatty acid elongase activity narrowMatch 36923
fatty acid elongase activity database_cross_reference “RHEA:36919”
fatty acid elongase activity narrowMatch 36807
fatty acid elongase activity narrowMatch 36943
fatty acid elongase activity narrowMatch 36963
fatty acid elongase activity database_cross_reference “RHEA:36943”
fatty acid elongase activity narrowMatch 36515
fatty acid elongase activity database_cross_reference “RHEA:36947”
fatty acid elongase activity database_cross_reference “RHEA:37243”
fatty acid elongase activity database_cross_reference “RHEA:36519”

fatty acid elongation, unsaturated fatty acid `http://purl.obolibrary.org/obo/GO_0019368`

Removed

fatty acid elongation, unsaturated fatty acid database_cross_reference “MetaCyc:PWY0-862”

Added

fatty acid elongation, unsaturated fatty acid term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI

fatty acid omega-1 hydroxylase activity `http://purl.obolibrary.org/obo/GO_0120502`

Added

fatty acid omega-1 hydroxylase activity narrowMatch 39751
fatty acid omega-1 hydroxylase activity database_cross_reference “RHEA:39751”
fatty acid omega-1 hydroxylase activity database_cross_reference “RHEA:39759”
fatty acid omega-1 hydroxylase activity narrowMatch 39759

fatty acid omega-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0120250`

Added

fatty acid omega-hydroxylase activity narrowMatch 40079
fatty acid omega-hydroxylase activity database_cross_reference “RHEA:40079”

fatty acid-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0120515`

Added

fatty acid-CoA ligase activity narrowMatch 44004
fatty acid-CoA ligase activity database_cross_reference “RHEA:44004”

fatty acyl-[ACP] hydrolase activity `http://purl.obolibrary.org/obo/GO_0016297`

Added

fatty acyl-[ACP] hydrolase activity database_cross_reference “RHEA:30119”
fatty acyl-[ACP] hydrolase activity narrowMatch 30131
fatty acyl-[ACP] hydrolase activity narrowMatch 41932
fatty acyl-[ACP] hydrolase activity database_cross_reference “RHEA:30115”
fatty acyl-[ACP] hydrolase activity narrowMatch 15057
fatty acyl-[ACP] hydrolase activity narrowMatch 30119
fatty acyl-[ACP] hydrolase activity narrowMatch 63204
fatty acyl-[ACP] hydrolase activity database_cross_reference “RHEA:63204”
fatty acyl-[ACP] hydrolase activity narrowMatch 30123
fatty acyl-[ACP] hydrolase activity narrowMatch 30115
fatty acyl-[ACP] hydrolase activity database_cross_reference “RHEA:30131”
fatty acyl-[ACP] hydrolase activity database_cross_reference “RHEA:15057”
fatty acyl-[ACP] hydrolase activity database_cross_reference “RHEA:41932”
fatty acyl-[ACP] hydrolase activity database_cross_reference “RHEA:30123”

fatty aldehyde dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0102673`

Added

fatty aldehyde dehydrogenase (NAD+) activity narrowMatch 69771
fatty aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:44008”
fatty aldehyde dehydrogenase (NAD+) activity narrowMatch 44008
fatty aldehyde dehydrogenase (NAD+) activity database_cross_reference “RHEA:69771”

fatty-acyl-ethyl-ester synthase activity `http://purl.obolibrary.org/obo/GO_0030339`

Added

fatty-acyl-ethyl-ester synthase activity database_cross_reference “RHEA:50316”
fatty-acyl-ethyl-ester synthase activity narrowMatch 50316
fatty-acyl-ethyl-ester synthase activity narrowMatch 50132
fatty-acyl-ethyl-ester synthase activity database_cross_reference “RHEA:50132”

fear response `http://purl.obolibrary.org/obo/GO_0042596`

Removed

fear response definition “The response of an organism to a perceived external threat.”
- database_cross_reference “GOC:go_curators”

Added

fear response definition “The response of an organism to a perceived external threat.”
- database_cross_reference “GOC:curators”

ferredoxin-NADP+ reductase activity `http://purl.obolibrary.org/obo/GO_0004324`

Added

ferredoxin-NADP+ reductase activity database_cross_reference “Reactome:R-HSA-2395512”
- label “FDXR transfers electrons to FDX1,2 (FDX1L)”
ferredoxin-NADP+ reductase activity database_cross_reference “Reactome:R-HSA-2395517”
- label “NADPH transfers electrons to FDXR”

ferric-chelate reductase (NADPH) activity `http://purl.obolibrary.org/obo/GO_0052851`

Added

ferric-chelate reductase (NADPH) activity database_cross_reference “Reactome:R-HSA-9927945”
- label “YqjH reduces FeEnt”

ferric-enterobactin transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015620`

Added

ferric-enterobactin transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9911603”
- label “FepC:FepD:FepG transports ferrienterobactin from the periplasmic space to the cytosol”
ferric-enterobactin transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9911602”
- label “FepA:TonB:ExbB:ExbD transports ferrienterobactin from the extracellular region to the periplasmic space”

ferrous iron binding `http://purl.obolibrary.org/obo/GO_0008198`

Added

ferrous iron binding database_cross_reference “Reactome:R-HSA-1362416”
- label “Frataxin binds iron”

ferrous iron transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015093`

Added

ferrous iron transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9911598”
- label “EfeUOB transport Fe2+ from periplasmic space to the cytosol”
ferrous iron transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9911596”
- label “FeoAB transports Fe2+ from periplasmic space to the cytosol”

fertilization `http://purl.obolibrary.org/obo/GO_0009566`

Added

fertilization has_related_synonym “cell-cell fusion”
fertilization has_related_synonym “https://github.com/geneontology/go-ontology/issues/31270”

fetal process involved in parturition `http://purl.obolibrary.org/obo/GO_0060138`

Removed

fetal process involved in parturition definition “A reproductive process occurring in the embryo that results in birth.”
- database_cross_reference “GOC:dph”

Added

fetal process involved in parturition term tracker item “https://github.com/geneontology/go-ontology/issues/31526”^^anyURI
fetal process involved in parturition definition “A reproductive process occurring in the fetus that results in birth.”
- database_cross_reference “GOC:dph”

fibrillar collagen trimer `http://purl.obolibrary.org/obo/GO_0005583`

Added

fibrillar collagen trimer SubClassOf extracellular protein-containing complex

fibrinogen complex `http://purl.obolibrary.org/obo/GO_0005577`

Removed

fibrinogen complex SubClassOf part of some obsolete extracellular space
fibrinogen complex SubClassOf protein-containing complex

Added

fibrinogen complex SubClassOf extracellular protein-containing complex

first spliceosomal transesterification activity `http://purl.obolibrary.org/obo/GO_0000384`

Added

first spliceosomal transesterification activity database_cross_reference “Reactome:R-HSA-9794542”
- label “Formation of the Spliceosomal C complex containing intron lariat”

flavanone 2-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0033771`

Added

flavanone 2-hydroxylase activity database_cross_reference “RHEA:57592”
flavanone 2-hydroxylase activity narrowMatch 57596
flavanone 2-hydroxylase activity database_cross_reference “RHEA:57596”
flavanone 2-hydroxylase activity narrowMatch 57592

flavanone 3-dioxygenase activity `http://purl.obolibrary.org/obo/GO_0045486`

Added

flavanone 3-dioxygenase activity narrowMatch 61084
flavanone 3-dioxygenase activity narrowMatch 61088
flavanone 3-dioxygenase activity database_cross_reference “RHEA:61088”
flavanone 3-dioxygenase activity database_cross_reference “RHEA:61084”

flavanone 4’-O-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0102767`

Added

flavone 3’-O-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0102822`

Added

flavone 3’-O-methyltransferase activity narrowMatch 60944
flavone 3’-O-methyltransferase activity database_cross_reference “RHEA:60944”
flavone 3’-O-methyltransferase activity database_cross_reference “RHEA:14589”
flavone 3’-O-methyltransferase activity narrowMatch 14589

flavone synthase activity `http://purl.obolibrary.org/obo/GO_0033759`

Added

flavone synthase activity narrowMatch 32755
flavone synthase activity database_cross_reference “RHEA:32755”

flavonoid 3’,5’-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0033772`

Added

flavonoid 3’,5’-hydroxylase activity narrowMatch 61108
flavonoid 3’,5’-hydroxylase activity database_cross_reference “RHEA:61120”
flavonoid 3’,5’-hydroxylase activity database_cross_reference “RHEA:61104”
flavonoid 3’,5’-hydroxylase activity database_cross_reference “RHEA:61108”
flavonoid 3’,5’-hydroxylase activity narrowMatch 61104
flavonoid 3’,5’-hydroxylase activity narrowMatch 61120

flavonoid 3’-monooxygenase activity `http://purl.obolibrary.org/obo/GO_0016711`

Added

flavonoid 3’-monooxygenase activity narrowMatch 61096
flavonoid 3’-monooxygenase activity database_cross_reference “RHEA:61124”
flavonoid 3’-monooxygenase activity narrowMatch 79895
flavonoid 3’-monooxygenase activity narrowMatch 61124
flavonoid 3’-monooxygenase activity database_cross_reference “RHEA:61112”
flavonoid 3’-monooxygenase activity database_cross_reference “RHEA:79895”
flavonoid 3’-monooxygenase activity narrowMatch 61112
flavonoid 3’-monooxygenase activity database_cross_reference “RHEA:61096”

flavonoid transport from endoplasmic reticulum to plant-type vacuole `http://purl.obolibrary.org/obo/GO_1903415`

Removed

flavonoid transport from endoplasmic reticulum to plant-type vacuole SubClassOf transport

Added

flavonoid transport from endoplasmic reticulum to plant-type vacuole SubClassOf intercellular transport

flavonol 3-O-glucosyltransferase activity `http://purl.obolibrary.org/obo/GO_0047893`

Added

flavonol 3-O-glucosyltransferase activity database_cross_reference “RHEA:61180”
flavonol 3-O-glucosyltransferase activity narrowMatch 61180

flavonol synthase activity `http://purl.obolibrary.org/obo/GO_0045431`

Added

flavonol synthase activity narrowMatch 61136
flavonol synthase activity database_cross_reference “RHEA:61132”
flavonol synthase activity database_cross_reference “RHEA:61136”
flavonol synthase activity narrowMatch 61132
flavonol synthase activity narrowMatch 61140
flavonol synthase activity database_cross_reference “RHEA:61140”

flavonol-3-O-beta-glucoside O-malonyltransferase activity `http://purl.obolibrary.org/obo/GO_0047165`

Added

floral organ development `http://purl.obolibrary.org/obo/GO_0048437`

Removed

floral organ development definition “The process whose specific outcome is the progression of the floral organ over time, from its formation to the mature structure.”
- database_cross_reference “PO:0025395”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:PO_curators”

Added

floral organ development definition “The process whose specific outcome is the progression of the floral organ over time, from its formation to the mature structure.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PO:0025395”
- database_cross_reference “GOC:PO_curators”

floral organ morphogenesis `http://purl.obolibrary.org/obo/GO_0048444`

Removed

floral organ morphogenesis definition “The process in which the anatomical structures of the floral organ are generated and organized.”
- database_cross_reference “PO:0025395”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:PO_curators”

Added

floral organ morphogenesis definition “The process in which the anatomical structures of the floral organ are generated and organized.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PO:0025395”
- database_cross_reference “GOC:PO_curators”

floral whorl development `http://purl.obolibrary.org/obo/GO_0048438`

Removed

floral whorl development definition “The process whose specific outcome is the progression of a floral whorl over time, from its formation to the mature structure. A floral whorl is a circular arrangement of parts of a flower arising from a stem of a plant.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”
- database_cross_reference “PO:0025023”
- database_cross_reference “GOC:PO_curators”

Added

floral whorl development definition “The process whose specific outcome is the progression of a floral whorl over time, from its formation to the mature structure. A floral whorl is a circular arrangement of parts of a flower arising from a stem of a plant.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”
- database_cross_reference “PO:0025023”
- database_cross_reference “GOC:PO_curators”

floral whorl morphogenesis `http://purl.obolibrary.org/obo/GO_0048457`

Removed

floral whorl morphogenesis definition “The process in which the anatomical structures of the floral whorl are generated and organized.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PO:0025023”
- database_cross_reference “GOC:PO_curators”

Added

floral whorl morphogenesis definition “The process in which the anatomical structures of the floral whorl are generated and organized.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PO:0025023”
- database_cross_reference “GOC:PO_curators”

flower calyx development `http://purl.obolibrary.org/obo/GO_0048464`

Removed

flower calyx development definition “The process whose specific outcome is the progression of the flower calyx over time, from its formation to the mature structure.”
- database_cross_reference “GOC:go_curators”

Added

flower calyx development definition “The process whose specific outcome is the progression of the flower calyx over time, from its formation to the mature structure.”
- database_cross_reference “GOC:curators”

flower morphogenesis `http://purl.obolibrary.org/obo/GO_0048439`

Removed

flower morphogenesis definition “The process in which the anatomical structures of the flower are generated and organized.”
- database_cross_reference “GOC:go_curators”

Added

flower morphogenesis definition “The process in which the anatomical structures of the flower are generated and organized.”
- database_cross_reference “GOC:curators”

fluorene catabolic process `http://purl.obolibrary.org/obo/GO_0019429`

Added

fluorene catabolic process narrowMatch FLUORENE-DEG-9-ONE-PWY
fluorene catabolic process narrowMatch PWY-1381
fluorene catabolic process database_cross_reference “MetaCyc:PWY-1381”
fluorene catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI

folate import into mitochondrion `http://purl.obolibrary.org/obo/GO_1904947`

Added

folate import into mitochondrion SubClassOf intercellular transport

folic acid receptor activity `http://purl.obolibrary.org/obo/GO_0061714`

Added

folic acid receptor activity database_cross_reference “Reactome:R-HSA-8940134”
- label “FOLR2 binds FOLA”

folic acid transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0008517`

Removed

folic acid transmembrane transporter activity database_cross_reference “Reactome:R-HSA-200729”
- label “SLC46A1 transports FOLA from extracellular region to cytosol”
folic acid transmembrane transporter activity database_cross_reference “Reactome:R-HSA-200646”
- label “Cytosolic folate export across the plasma membrane”

folic acid:proton symporter activity `http://purl.obolibrary.org/obo/GO_0140211`

Added

folic acid:proton symporter activity database_cross_reference “Reactome:R-HSA-200729”
- label “SLC46A1 transports FOLA from extracellular region to cytosol”
folic acid:proton symporter activity database_cross_reference “Reactome:R-HSA-200646”
- label “Cytosolic folate export across the plasma membrane”

forelimb morphogenesis `http://purl.obolibrary.org/obo/GO_0035136`

Removed

forelimb morphogenesis definition “The process in which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human.”
- database_cross_reference “GOC:go_curators”

Added

forelimb morphogenesis definition “The process in which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human.”
- database_cross_reference “GOC:curators”

formate dehydrogenase (quinone) activity `http://purl.obolibrary.org/obo/GO_0036397`

Added

formate dehydrogenase (quinone) activity database_cross_reference “RHEA:29063”
formate dehydrogenase (quinone) activity database_cross_reference “RHEA:29071”
formate dehydrogenase (quinone) activity narrowMatch 29063
formate dehydrogenase (quinone) activity narrowMatch 29071

formation of primary germ layer `http://purl.obolibrary.org/obo/GO_0001704`

Removed

formation of primary germ layer definition “The formation of the ectoderm, mesoderm and endoderm during gastrulation.”
- database_cross_reference “GOC:go_curators”

Added

formation of primary germ layer definition “The formation of the ectoderm, mesoderm and endoderm during gastrulation.”
- database_cross_reference “GOC:curators”

formimidoylaspartate deiminase activity `http://purl.obolibrary.org/obo/GO_0050414`

Removed

formimidoylaspartate deiminase activity definition “Catalysis of the reaction: N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3.”
- database_cross_reference “MetaCyc:FORMIMINOASPARTATE-DEIMINASE-RXN”
- database_cross_reference “EC:3.5.3.5”

Added

formimidoylaspartate deiminase activity definition “Catalysis of the reaction: N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH4+.”
- database_cross_reference “RHEA:13661”

formimidoylglutamate deiminase activity `http://purl.obolibrary.org/obo/GO_0050416`

Removed

formimidoylglutamate deiminase activity definition “Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH3.”
- database_cross_reference “EC:3.5.3.13”
- database_cross_reference “MetaCyc:FORMIMINOGLUTAMATE-DEIMINASE-RXN”

Added

formimidoylglutamate deiminase activity definition “Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH4+.”
- database_cross_reference “RHEA:22832”

forward locomotion `http://purl.obolibrary.org/obo/GO_0043056`

Removed

forward locomotion definition “Anterior movement of an organism, following the direction of the head of the animal.”
- database_cross_reference “GOC:go_curators”

Added

forward locomotion definition “Anterior movement of an organism, following the direction of the head of the animal.”
- database_cross_reference “GOC:curators”

free fatty acid 2-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0120520`

Added

free fatty acid 2-hydroxylase activity narrowMatch 38559
free fatty acid 2-hydroxylase activity database_cross_reference “RHEA:38551”
free fatty acid 2-hydroxylase activity narrowMatch 38551
free fatty acid 2-hydroxylase activity database_cross_reference “RHEA:38559”

fructose export from vacuole to cytoplasm `http://purl.obolibrary.org/obo/GO_1902334`

Added

fructose export from vacuole to cytoplasm SubClassOf intercellular transport

fructose-2,6-bisphosphate 2-phosphatase activity `http://purl.obolibrary.org/obo/GO_0004331`

Removed

fructose-2,6-bisphosphate 2-phosphatase activity database_cross_reference “Reactome:R-HSA-70262”
- label “Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate”

Added

fructose-2,6-bisphosphate 2-phosphatase activity database_cross_reference “Reactome:R-HSA-70262”
- label “PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate”

fructose-bisphosphate aldolase activity `http://purl.obolibrary.org/obo/GO_0004332`

Removed

fructose-bisphosphate aldolase activity database_cross_reference “Reactome:R-HSA-71496”
- label “D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate”

Added

fructose-bisphosphate aldolase activity database_cross_reference “Reactome:R-HSA-71496”
- label “Aldolase tetramer cleaves F1,6PP”

fucokinase activity `http://purl.obolibrary.org/obo/GO_0050201`

Removed

fucokinase activity database_cross_reference “Reactome:R-HSA-6787540”
- label “FUK phosphorylates beta-Fuc to Fuc1P”

Added

fucokinase activity database_cross_reference “Reactome:R-HSA-6787540”
- label “FCSK phosphorylates beta-Fuc to Fuc1P”

fucosylgalactoside 3-alpha-galactosyltransferase activity `http://purl.obolibrary.org/obo/GO_0004381`

Added

fucosyltransferase activity `http://purl.obolibrary.org/obo/GO_0008417`

Added

fucosyltransferase activity database_cross_reference “Reactome:R-HSA-9935449”
- label “FUT10 O-fucosylates EMI domain-containing proteins”
fucosyltransferase activity database_cross_reference “Reactome:R-HSA-9935469”
- label “FUT11 O-fucosylates EMI domain-containing proteins”

fungal-type cell wall `http://purl.obolibrary.org/obo/GO_0009277`

Removed

fungal-type cell wall definition “A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “PMID:16927300”
- database_cross_reference “PMID:3319422”
- database_cross_reference “GOC:mtg_sensu”
- database_cross_reference “PMID:11283274”
- database_cross_reference “ISBN:3540601864”

Added

fungal-type cell wall definition “A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “PMID:16927300”
- database_cross_reference “PMID:36266346”
- database_cross_reference “PMID:3319422”
- database_cross_reference “GOC:mtg_sensu”
- database_cross_reference “PMID:11283274”
- database_cross_reference “ISBN:3540601864”

fungal-type cell wall biogenesis `http://purl.obolibrary.org/obo/GO_0009272`

Removed

fungal-type cell wall biogenesis definition “A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a fungal-type cell wall. The fungal-type cell wall contains beta-glucan and may contain chitin.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_sensu”

Added

fungal-type cell wall biogenesis definition “A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a fungal-type cell wall. The fungal-type cell wall contains beta-glucan and may contain chitin.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_sensu”

fusion of sperm to egg plasma membrane involved in double fertilization forming a zygote and endosperm `http://purl.obolibrary.org/obo/GO_0061936`

Removed

fusion of sperm to egg plasma membrane involved in double fertilization forming a zygote and endosperm SubClassOf obsolete plasma membrane fusion

fusion of sperm to egg plasma membrane involved in single fertilization `http://purl.obolibrary.org/obo/GO_0007342`

Removed

fusion of sperm to egg plasma membrane involved in single fertilization SubClassOf obsolete plasma membrane fusion

fusome organization `http://purl.obolibrary.org/obo/GO_0045478`

Removed

fusome organization definition “A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome, a large intracellular spectrin-rich structure found in insect germline cells and mammalian hematopoietic cells.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:go_curators”

Added

fusome organization definition “A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome, a large intracellular spectrin-rich structure found in insect germline cells and mammalian hematopoietic cells.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:curators”

galactarate metabolic process `http://purl.obolibrary.org/obo/GO_0019580`

Added

galactarate metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/27059”^^anyURI
galactarate metabolic process SubClassOf carbohydrate metabolic process

galactolipid biosynthetic process `http://purl.obolibrary.org/obo/GO_0019375`

Added

galactolipid biosynthetic process narrowMatch PWY-7666
galactolipid biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
galactolipid biosynthetic process database_cross_reference “MetaCyc:PWY-401”
galactolipid biosynthetic process database_cross_reference “MetaCyc:PWY-7666”
galactolipid biosynthetic process narrowMatch PWY-401

galactosamine-6-phosphate isomerase activity `http://purl.obolibrary.org/obo/GO_0043877`

Removed

galactosamine-6-phosphate isomerase activity definition “Catalysis of the reaction: D-galactosamine 6-phosphate + H2O = D-tagatose 6-phosphate + NH3.”
- database_cross_reference “PMID:10931310”

Added

galactosamine-6-phosphate isomerase activity definition “Catalysis of the reaction: D-galactosamine 6-phosphate + H2O = D-tagatose 6-phosphate + NH4+.”
- database_cross_reference “PMID:10931310”

galactose oxidase activity `http://purl.obolibrary.org/obo/GO_0045480`

Removed

galactose oxidase activity definition “Catalysis of the reaction: D-galactose + O2 = D-galacto-hexodialdose + hydrogen peroxide.”
- database_cross_reference “EC:1.1.3.9”

Added

galactose oxidase activity definition “Catalysis of the reaction: D-galactose + O2 = D-galacto-hexodialdose + H2O2.”
- database_cross_reference “RHEA:24160”

galactoside 2-alpha-L-fucosyltransferase activity `http://purl.obolibrary.org/obo/GO_0008107`

Added

galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity `http://purl.obolibrary.org/obo/GO_0015018`

Removed

galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity database_cross_reference “Reactome:R-HSA-9638064”
- label “B3GAT3 dimer transfers GlcA to tetrasaccharide linker”

gamma-aminobutyric acid transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015185`

Removed

gamma-aminobutyric acid transmembrane transporter activity definition “Enables the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA).”
- database_cross_reference “ISBN:0815340729”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_transport”
- database_cross_reference “ISBN:0198506732”

Added

gamma-aminobutyric acid transmembrane transporter activity definition “Enables the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA).”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0815340729”
- database_cross_reference “GOC:mtg_transport”
- database_cross_reference “ISBN:0198506732”

gamma-aminobutyric acid transport `http://purl.obolibrary.org/obo/GO_0015812`

Removed

gamma-aminobutyric acid transport definition “The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

gamma-aminobutyric acid transport definition “The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

gamma-glutamylcyclotransferase activity `http://purl.obolibrary.org/obo/GO_0003839`

Removed

gamma-glutamylcyclotransferase activity database_cross_reference “Reactome:R-HSA-6785928”
- label “CHAC1,2 cleaves GSH to OPRO and CysGly”

ganglion mother cell fate determination `http://purl.obolibrary.org/obo/GO_0007402`

Removed

ganglion mother cell fate determination definition “The cell fate determination process in which a cell becomes capable of differentiating autonomously into a ganglion mother cell regardless of its environment; upon determination, the cell fate cannot be reversed.”
- database_cross_reference “GOC:go_curators”

Added

ganglion mother cell fate determination definition “The cell fate determination process in which a cell becomes capable of differentiating autonomously into a ganglion mother cell regardless of its environment; upon determination, the cell fate cannot be reversed.”
- database_cross_reference “GOC:curators”

gastrulation involving germ band extension `http://purl.obolibrary.org/obo/GO_0010004`

Removed

gastrulation involving germ band extension definition “A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_sensu”

Added

gastrulation involving germ band extension definition “A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_sensu”

gastrulation with mouth forming first `http://purl.obolibrary.org/obo/GO_0001703`

Removed

gastrulation with mouth forming first definition “A gastrulation process in which the initial invagination becomes the mouth and the anus forms second.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_sensu”

Added

gastrulation with mouth forming first definition “A gastrulation process in which the initial invagination becomes the mouth and the anus forms second.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_sensu”

gastrulation with mouth forming second `http://purl.obolibrary.org/obo/GO_0001702`

Removed

gastrulation with mouth forming second definition “A gastrulation process in which the initial invagination becomes the anus and the mouth forms second.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_sensu”

Added

gastrulation with mouth forming second definition “A gastrulation process in which the initial invagination becomes the anus and the mouth forms second.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_sensu”

geranylgeranyl diphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0033386`

Added

geranylgeranyl diphosphate biosynthetic process narrowMatch PWY-5120
geranylgeranyl diphosphate biosynthetic process database_cross_reference “MetaCyc:PWY-5120”
geranylgeranyl diphosphate biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI

geranylgeranyl diphosphate synthase activity `http://purl.obolibrary.org/obo/GO_0004311`

Removed

geranylgeranyl diphosphate synthase activity relatedMatch PWY-5120
geranylgeranyl diphosphate synthase activity comment “The catalyzed reaction forms (free) geranylgeranyl diphosphate. There is no relationship between this activity and protein farnesyltransferase activity, GO:0004660, where the catalyzed reaction transfers a farnesyl group from farnesyl diphosphate to a target protein. Note that this term has a MetaCyc pathway reference as the pathway only has a single step.”

Added

geranylgeranyl diphosphate synthase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI
geranylgeranyl diphosphate synthase activity comment “The catalyzed reaction forms (free) geranylgeranyl diphosphate. There is no relationship between this activity and protein farnesyltransferase activity, GO:0004660, where the catalyzed reaction transfers a farnesyl group from farnesyl diphosphate to a target protein.”

germ cell development `http://purl.obolibrary.org/obo/GO_0007281`

Removed

germ cell development definition “The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.”
- database_cross_reference “GOC:go_curators”

Added

germ cell development definition “The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.”
- database_cross_reference “GOC:curators”

germ cell nucleus `http://purl.obolibrary.org/obo/GO_0043073`

Removed

germ cell nucleus definition “The nucleus of a germ cell, a reproductive cell in multicellular organisms.”
- database_cross_reference “CL:0000586”
- database_cross_reference “GOC:go_curators”

Added

germ cell nucleus definition “The nucleus of a germ cell, a reproductive cell in multicellular organisms.”
- database_cross_reference “GOC:curators”
- database_cross_reference “CL:0000586”

gibberellin catabolic process `http://purl.obolibrary.org/obo/GO_0045487`

Removed

gibberellin catabolic process definition “The chemical reactions and pathways resulting in the breakdown of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators.”
- database_cross_reference “GOC:go_curators”

Added

gibberellin catabolic process definition “The chemical reactions and pathways resulting in the breakdown of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators.”
- database_cross_reference “GOC:curators”

glial cell differentiation `http://purl.obolibrary.org/obo/GO_0010001`

Removed

glial cell differentiation definition “The process in which a relatively unspecialized cell acquires the specialized features of a glial cell.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_sensu”

Added

glial cell differentiation definition “The process in which a relatively unspecialized cell acquires the specialized features of a glial cell.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_sensu”

glial cell fate determination `http://purl.obolibrary.org/obo/GO_0007403`

Removed

glial cell fate determination definition “The cell fate determination process in which a cell becomes capable of differentiating autonomously into a glial cell regardless of its environment; upon determination, the cell fate cannot be reversed.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_sensu”

Added

glial cell fate determination definition “The cell fate determination process in which a cell becomes capable of differentiating autonomously into a glial cell regardless of its environment; upon determination, the cell fate cannot be reversed.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_sensu”

glucagon receptor activity `http://purl.obolibrary.org/obo/GO_0004967`

Added

glucagon receptor activity database_cross_reference “Reactome:R-HSA-163625”
- label “Glucagon binds to Glucagon receptor”

glucan 1,3-alpha-glucosidase activity `http://purl.obolibrary.org/obo/GO_0033919`

Added

glucan 1,3-alpha-glucosidase activity database_cross_reference “Reactome:R-HSA-9932913”
- label “Glucosidase II removes glucose residue from Glu1Man9GlucNAc2-CDH1”
glucan 1,3-alpha-glucosidase activity database_cross_reference “Reactome:R-HSA-9932352”
- label “Glucosidase II removes glucose residue from Glu2Man9GlucNAc2-CDH1”

glucan biosynthetic process `http://purl.obolibrary.org/obo/GO_0009250`

Removed

glucan biosynthetic process definition “The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues.”
- database_cross_reference “GOC:go_curators”

Added

glucan biosynthetic process definition “The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues.”
- database_cross_reference “GOC:curators”

glucan catabolic process `http://purl.obolibrary.org/obo/GO_0009251`

Removed

glucan catabolic process definition “The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues.”
- database_cross_reference “GOC:go_curators”

Added

glucan catabolic process definition “The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues.”
- database_cross_reference “GOC:curators”

glucokinase activity `http://purl.obolibrary.org/obo/GO_0004340`

Added

glucokinase activity database_cross_reference “RHEA:36495”
glucokinase activity narrowMatch 36495

glucosaminate ammonia-lyase activity `http://purl.obolibrary.org/obo/GO_0047930`

Removed

glucosaminate ammonia-lyase activity definition “Catalysis of the reaction: D-glucosaminate = 2-dehydro-3-deoxy-D-gluconate + NH3.”
- database_cross_reference “EC:4.3.1.9”

Added

glucosaminate ammonia-lyase activity definition “Catalysis of the reaction: 2-amino-2-deoxy-D-gluconate = 2-dehydro-3-deoxy-D-gluconate + NH4+.”
- database_cross_reference “RHEA:12488”

glucosaminyl-phosphatidylinositol O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0032216`

Added

glucose homeostasis `http://purl.obolibrary.org/obo/GO_0042593`

Removed

glucose homeostasis definition “Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.”
- database_cross_reference “GOC:go_curators”

Added

glucose homeostasis definition “Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.”
- database_cross_reference “GOC:curators”

glucose sensor activity `http://purl.obolibrary.org/obo/GO_0141089`

Added

glucose sensor activity database_cross_reference “Reactome:R-HSA-170810”
- label “nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR)”

glucose-6-phosphatase activity `http://purl.obolibrary.org/obo/GO_0004346`

Added

glucose-6-phosphatase activity narrowMatch 44904
glucose-6-phosphatase activity database_cross_reference “RHEA:44904”

glucose-6-phosphate dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0004345`

Removed

glucose-6-phosphate dehydrogenase activity database_cross_reference “Reactome:R-HSA-70377”
- label “alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+”

Added

glucose-6-phosphate dehydrogenase activity database_cross_reference “Reactome:R-HSA-70377”
- label “G6PD multimers dehydrogenate G6P”

glucose-6-phosphate isomerase activity `http://purl.obolibrary.org/obo/GO_0004347`

Removed

glucose-6-phosphate isomerase activity database_cross_reference “Reactome:R-HSA-70471”
- label “alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate”

Added

glucose-6-phosphate isomerase activity database_cross_reference “Reactome:R-HSA-70471”
- label “GPI dimer isomerizes G6P”

glucosylceramidase activity `http://purl.obolibrary.org/obo/GO_0004348`

Added

glucosylceramidase activity narrowMatch 59284
glucosylceramidase activity database_cross_reference “RHEA:59284”

glucuronate catabolic process `http://purl.obolibrary.org/obo/GO_0006064`

Removed

glucuronate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid.”
- database_cross_reference “GOC:go_curators”

Added

glucuronate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid.”
- database_cross_reference “GOC:curators”

glucuronate metabolic process `http://purl.obolibrary.org/obo/GO_0019585`

Removed

glucuronate metabolic process definition “The chemical reactions and pathways involving glucuronate, any salt or ester of glucuronic acid, the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

glucuronate metabolic process database_cross_reference “Reactome:R-HSA-156588”
- label “Glucuronidation”
glucuronate metabolic process definition “The chemical reactions and pathways involving glucuronate, any salt or ester of glucuronic acid, the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

glucuronate transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015135`

Added

glucuronate transmembrane transporter activity database_cross_reference “Reactome:R-HSA-2162229”
- label “SLC17A5 exports GlcA from the lysosome to the cytosol”

glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity `http://purl.obolibrary.org/obo/GO_0047238`

Removed

glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity database_cross_reference “Reactome:R-HSA-1971487”
- label “CHPF,CHSY3 transfer GalNAc to chondroitin”
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity database_cross_reference “Reactome:R-HSA-1971482”
- label “The addition of GalNAc to the terminal glucuronate residue forms chondroitin”
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity database_cross_reference “Reactome:R-HSA-9632033”
- label “CHSY1 transfers GalNAc to chondroitin”

Added

glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity database_cross_reference “Reactome:R-HSA-1971482”
- label “CSGALNACTs transfer GalNAc to CS linker glycan”
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity database_cross_reference “Reactome:R-HSA-9632033”
- label “CSGALNACTs transfer GalNAc to CS chain”
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity database_cross_reference “Reactome:R-HSA-1971487”
- label “Chondroitin polymerase complex transfers GalNAc to CS chain”

glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity `http://purl.obolibrary.org/obo/GO_0050508`

Removed

glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity database_cross_reference “Reactome:R-HSA-9036283”
- label “Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the terminal GlcA residue”
glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity database_cross_reference “Reactome:R-HSA-2022851”
- label “EXT1:EXT2 transfer GlcNAc to the heparan chain”
glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity database_cross_reference “Reactome:R-HSA-2022919”
- label “EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue”
glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity database_cross_reference “Reactome:R-HSA-9036290”
- label “Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to heparan”

Added

glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity database_cross_reference “Reactome:R-HSA-2022851”
- label “EXT1:EXT2 transfers GlcNAc to the heparan chain”

glucuronosyltransferase activity `http://purl.obolibrary.org/obo/GO_0015020`

Removed

glucuronosyltransferase activity database_cross_reference “Reactome:R-HSA-5617143”
- label “B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA”
glucuronosyltransferase activity database_cross_reference “Reactome:R-HSA-9638097”
- label “B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA”

Added

glucuronosyltransferase activity narrowMatch 63748
glucuronosyltransferase activity database_cross_reference “RHEA:63720”
glucuronosyltransferase activity narrowMatch 63616
glucuronosyltransferase activity database_cross_reference “RHEA:63748”
glucuronosyltransferase activity database_cross_reference “RHEA:63692”
glucuronosyltransferase activity narrowMatch 79071
glucuronosyltransferase activity database_cross_reference “Reactome:R-HSA-5617143”
- label “B4GAT1:LARGE transfers initial GlcA to matriglycan chain”
glucuronosyltransferase activity narrowMatch 63716
glucuronosyltransferase activity database_cross_reference “RHEA:63616”
glucuronosyltransferase activity database_cross_reference “Reactome:R-HSA-9638097”
- label “LARGE1,2 elongates matriglycan chain with GlcA”
glucuronosyltransferase activity narrowMatch 63720
glucuronosyltransferase activity narrowMatch 63728
glucuronosyltransferase activity narrowMatch 63744
glucuronosyltransferase activity database_cross_reference “RHEA:63744”
glucuronosyltransferase activity database_cross_reference “RHEA:63728”
glucuronosyltransferase activity narrowMatch 63692
glucuronosyltransferase activity database_cross_reference “RHEA:75099”
glucuronosyltransferase activity narrowMatch 75099
glucuronosyltransferase activity database_cross_reference “RHEA:79075”
glucuronosyltransferase activity database_cross_reference “RHEA:79067”
glucuronosyltransferase activity narrowMatch 79075
glucuronosyltransferase activity narrowMatch 79067
glucuronosyltransferase activity database_cross_reference “RHEA:79071”
glucuronosyltransferase activity database_cross_reference “RHEA:63716”

glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity `http://purl.obolibrary.org/obo/GO_0001888`

Added

glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity database_cross_reference “Reactome:R-HSA-9953259”
- label “EXTL3 dimer transfers GlcNAc to the GAG linker”

glutamate metabolic process `http://purl.obolibrary.org/obo/GO_0006536`

Removed

glutamate metabolic process definition “The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.”
- database_cross_reference “GOC:go_curators”

Added

glutamate metabolic process definition “The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.”
- database_cross_reference “GOC:curators”

glutamate synthase (NADH) activity `http://purl.obolibrary.org/obo/GO_0016040`

Removed

glutamate synthase (NADH) activity relatedMatch GLUGLNSYN-PWY
glutamate synthase (NADH) activity definition “Catalysis of the reaction: 2 L-glutamate + NAD+ = 2-oxoglutarate + L-glutamine + H+ + NADH.”
- database_cross_reference “RHEA:13753”
- database_cross_reference “EC:1.4.1.14”
glutamate synthase (NADH) activity comment “Note that this term has a MetaCyc pathway reference as the pathway only has a single step.”

Added

glutamate synthase (NADH) activity definition “Catalysis of the reaction: 2 L-glutamate + NAD+ = 2-oxoglutarate + L-glutamine + H+ + NADH.”
- database_cross_reference “RHEA:13753”
glutamate synthase (NADH) activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI

glutamate synthase (NADPH) activity `http://purl.obolibrary.org/obo/GO_0004355`

Removed

glutamate synthase (NADPH) activity definition “Catalysis of the reaction: 2 L-glutamate + NADP+ = 2-oxoglutarate + L-glutamine + H+ + NADPH. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+.”
- database_cross_reference “EC:1.4.1.13”
- database_cross_reference “RHEA:15501”
glutamate synthase (NADPH) activity relatedMatch GLUTSYN-PWY
glutamate synthase (NADPH) activity comment “Note that this term has a MetaCyc pathway reference as the pathway only has a single step.”

Added

glutamate synthase (NADPH) activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI
glutamate synthase (NADPH) activity definition “Catalysis of the reaction: 2 L-glutamate + NADP+ = 2-oxoglutarate + L-glutamine + H+ + NADPH. This is a two-step reaction: (a) L-glutamate + NH4+ = L-glutamine + H2O, (b) L-glutamate + NADP+ + H2O = NH4+ + 2-oxoglutarate + NADPH + H+.”
- database_cross_reference “RHEA:15501”

glutamate synthase (ferredoxin) activity `http://purl.obolibrary.org/obo/GO_0016041`

Removed

glutamate synthase (ferredoxin) activity comment “Note that this term has a MetaCyc pathway reference as the pathway only has a single step.”
glutamate synthase (ferredoxin) activity relatedMatch PWY-4341
glutamate synthase (ferredoxin) activity definition “Catalysis of the reaction: 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + 2 oxidized ferredoxin + H2O = NH3 + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+.”
- database_cross_reference “EC:1.4.7.1”

Added

glutamate synthase (ferredoxin) activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI
glutamate synthase (ferredoxin) activity definition “Catalysis of the reaction: 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+. This is a two-step reaction: (a) L-glutamate + NH4+ = L-glutamine + H2O, (b) L-glutamate + 2 oxidized ferredoxin + H2O = NH4+ + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+.”
- database_cross_reference “EC:1.4.7.1”

glutamate-tRNA(Gln) ligase activity `http://purl.obolibrary.org/obo/GO_0050561`

Added

glutamate-tRNA(Gln) ligase activity narrowMatch 64612
glutamate-tRNA(Gln) ligase activity database_cross_reference “RHEA:64612”

glutamin-(asparagin-)ase activity `http://purl.obolibrary.org/obo/GO_0050417`

Removed

glutamin-(asparagin-)ase activity definition “Catalysis of the reaction: H2O + L-glutamine = NH3 + L-glutamate; and H2O + L-asparagine = NH3 + L-aspartate.”
- database_cross_reference “EC:3.5.1.38”

Added

glutamin-(asparagin-)ase activity definition “Catalysis of the reactions: H2O + L-glutamine = NH4 + L-glutamate; and H2O + L-asparagine = NH4 + L-aspartate.”
- database_cross_reference “EC:3.5.1.38”

glutaminase activity `http://purl.obolibrary.org/obo/GO_0004359`

Removed

glutaminase activity database_cross_reference “Reactome:R-HSA-70609”
- label “glutamine + H2O => glutamate + NH4+ [GLS]”

Added

glutaminase activity database_cross_reference “Reactome:R-HSA-70609”
- label “glutamine + H2O => glutamate + NH4+ (GLS)”

glutarate-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0047948`

Removed

glutarate-CoA ligase activity SubClassOf acid-thiol ligase activity

Added

glutarate-CoA ligase activity SubClassOf CoA-ligase activity

glutathione biosynthetic process `http://purl.obolibrary.org/obo/GO_0006750`

Removed

glutathione biosynthetic process database_cross_reference “Reactome:R-HSA-174403”
- label “Glutathione synthesis and recycling”

glutathione import into mitochondrion `http://purl.obolibrary.org/obo/GO_0160007`

Added

glutathione import into mitochondrion SubClassOf intercellular transport

glutathione metabolic process `http://purl.obolibrary.org/obo/GO_0006749`

Added

glutathione metabolic process database_cross_reference “Reactome:R-HSA-174403”
- label “Glutathione synthesis and recycling”

glutathione oxidase activity `http://purl.obolibrary.org/obo/GO_0047950`

Removed

glutathione oxidase activity definition “Catalysis of the reaction: 2 glutathione + O2 = glutathione disulfide + H2O2.”
- database_cross_reference “RHEA:24112”
- database_cross_reference “EC:1.8.3.3”
glutathione oxidase activity SubClassOf oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor

Added

glutathione oxidase activity definition “Catalysis of the reaction: 2 glutathione + O2 = glutathione disulfide + H2O2.”
- database_cross_reference “RHEA:24112”
glutathione oxidase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31518”^^anyURI
glutathione oxidase activity SubClassOf thiol oxidase activity

glutathione peroxidase activity `http://purl.obolibrary.org/obo/GO_0004602`

Removed

glutathione peroxidase activity definition “Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.”
- database_cross_reference “PMID:36771108”
- database_cross_reference “EC:1.11.1.9”

Added

glutathione peroxidase activity definition “Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O.”
- database_cross_reference “PMID:36771108”
- database_cross_reference “EC:1.11.1.9”

glutathione specific gamma-glutamylcyclotransferase activity `http://purl.obolibrary.org/obo/GO_0061928`

Added

glutathione specific gamma-glutamylcyclotransferase activity database_cross_reference “Reactome:R-HSA-6785928”
- label “CHAC1,2 cleaves GSH to OPRO and CysGly”

glutathione transferase activity `http://purl.obolibrary.org/obo/GO_0004364`

Added

glutathione transferase activity narrowMatch 51220
glutathione transferase activity database_cross_reference “RHEA:51220”

glutathione transmembrane import into vacuole `http://purl.obolibrary.org/obo/GO_0071996`

Added

glutathione transmembrane import into vacuole SubClassOf intercellular transport

glutathione-dependent sulfide quinone oxidoreductase activity `http://purl.obolibrary.org/obo/GO_0106436`

Added

glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `http://purl.obolibrary.org/obo/GO_0004365`

Removed

glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity database_cross_reference “Reactome:R-HSA-70449”
- label “D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+”

Added

glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity database_cross_reference “Reactome:R-HSA-70449”
- label “GADPH tetramer dehydrogenates GA3P”

glycerol catabolic process `http://purl.obolibrary.org/obo/GO_0019563`

Removed

glycerol catabolic process definition “The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

glycerol catabolic process definition “The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”
glycerol catabolic process database_cross_reference “MetaCyc:GLYCEROLMETAB-PWY”
glycerol catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
glycerol catabolic process narrowMatch GLYCEROLMETAB-PWY

glycerol metabolic process `http://purl.obolibrary.org/obo/GO_0006071`

Removed

glycerol metabolic process database_cross_reference “MetaCyc:GLYCEROLMETAB-PWY”

Added

glycerol metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI

glycerol-3-phosphate O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0004366`

Added

glycerol-3-phosphate O-acyltransferase activity database_cross_reference “RHEA:35727”
glycerol-3-phosphate O-acyltransferase activity database_cross_reference “RHEA:37463”
glycerol-3-phosphate O-acyltransferase activity database_cross_reference “RHEA:37199”
glycerol-3-phosphate O-acyltransferase activity narrowMatch 35727
glycerol-3-phosphate O-acyltransferase activity database_cross_reference “RHEA:37195”
glycerol-3-phosphate O-acyltransferase activity database_cross_reference “RHEA:37203”
glycerol-3-phosphate O-acyltransferase activity database_cross_reference “RHEA:35731”
glycerol-3-phosphate O-acyltransferase activity narrowMatch 37203
glycerol-3-phosphate O-acyltransferase activity narrowMatch 37463
glycerol-3-phosphate O-acyltransferase activity database_cross_reference “RHEA:35723”
glycerol-3-phosphate O-acyltransferase activity narrowMatch 37199
glycerol-3-phosphate O-acyltransferase activity narrowMatch 35731
glycerol-3-phosphate O-acyltransferase activity narrowMatch 37195
glycerol-3-phosphate O-acyltransferase activity narrowMatch 35723

glycerol-3-phosphate dehydrogenase (quinone) activity `http://purl.obolibrary.org/obo/GO_0004368`

Added

glycerol-3-phosphate metabolic process `http://purl.obolibrary.org/obo/GO_0006072`

Removed

glycerol-3-phosphate metabolic process definition “The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

glycerol-3-phosphate metabolic process definition “The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

glycerone-phosphate O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0016287`

Added

glycerophosphodiester phosphodiesterase activity `http://purl.obolibrary.org/obo/GO_0008889`

Added

glycerophospholipid flippase activity `http://purl.obolibrary.org/obo/GO_0140333`

Removed

glycerophospholipid flippase activity SubClassOf obsolete phospholipid transporter activity

glycerophospholipid phospholipase A1 activity `http://purl.obolibrary.org/obo/GO_0008970`

Added

glycerophospholipid phospholipase A1 activity database_cross_reference “RHEA:18689”
glycerophospholipid phospholipase A1 activity database_cross_reference “RHEA:44408”
glycerophospholipid phospholipase A1 activity narrowMatch 62032
glycerophospholipid phospholipase A1 activity narrowMatch 44648
glycerophospholipid phospholipase A1 activity database_cross_reference “RHEA:44648”
glycerophospholipid phospholipase A1 activity database_cross_reference “RHEA:42212”
glycerophospholipid phospholipase A1 activity narrowMatch 44408
glycerophospholipid phospholipase A1 activity database_cross_reference “Reactome:R-HSA-8869425”
- label “PLA1A hydrolyses PS to 2-acyl LPS”
glycerophospholipid phospholipase A1 activity narrowMatch 67428
glycerophospholipid phospholipase A1 activity database_cross_reference “RHEA:35263”
glycerophospholipid phospholipase A1 activity narrowMatch 42212
glycerophospholipid phospholipase A1 activity database_cross_reference “RHEA:62032”
glycerophospholipid phospholipase A1 activity narrowMatch 35263
glycerophospholipid phospholipase A1 activity narrowMatch 18689
glycerophospholipid phospholipase A1 activity database_cross_reference “RHEA:67428”

glycine C-acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0008890`

Added

glycine C-acetyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31474”^^anyURI
glycine C-acetyltransferase activity SubClassOf amino acid acyltransferase activity

glycine N-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0047961`

Removed

glycine N-acyltransferase activity definition “Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine.”
- database_cross_reference “MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN”
- database_cross_reference “EC:2.3.1.13”
glycine N-acyltransferase activity SubClassOf N-acyltransferase activity

Added

glycine N-acyltransferase activity narrowMatch 49788
glycine N-acyltransferase activity database_cross_reference “RHEA:64244”
glycine N-acyltransferase activity narrowMatch 64244
glycine N-acyltransferase activity definition “Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine.”
- database_cross_reference “RHEA:19869”
glycine N-acyltransferase activity database_cross_reference “RHEA:49788”
glycine N-acyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31474”^^anyURI
glycine N-acyltransferase activity SubClassOf amino acid acyltransferase activity

glycine betaine biosynthetic process from glycine `http://purl.obolibrary.org/obo/GO_0019286`

Removed

glycine betaine biosynthetic process from glycine definition “The chemical reactions and pathways resulting in the formation of glycine betaine from other compounds, including glycine.”
- database_cross_reference “GOC:go_curators”

Added

glycine betaine biosynthetic process from glycine definition “The chemical reactions and pathways resulting in the formation of glycine betaine from other compounds, including glycine.”
- database_cross_reference “GOC:curators”

glycine biosynthetic process `http://purl.obolibrary.org/obo/GO_0006545`

Removed

glycine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “MetaCyc:GLYCINE-SYN2-PWY”

Added

glycine biosynthetic process database_cross_reference “MetaCyc:GLYSYN-THR-PWY”
glycine biosynthetic process database_cross_reference “MetaCyc:GLYSYN-PWY”
glycine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
glycine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid.”
- database_cross_reference “GOC:curators”
- database_cross_reference “MetaCyc:GLYCINE-SYN2-PWY”
glycine biosynthetic process narrowMatch GLYSYN-ALA-PWY
glycine biosynthetic process narrowMatch GLYSYN-THR-PWY
glycine biosynthetic process narrowMatch GLYSYN-PWY
glycine biosynthetic process database_cross_reference “MetaCyc:PWY-8551”
glycine biosynthetic process narrowMatch PWY-8551
glycine biosynthetic process database_cross_reference “MetaCyc:GLYSYN-ALA-PWY”

glycine catabolic process `http://purl.obolibrary.org/obo/GO_0006546`

Removed

glycine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid.”
- database_cross_reference “GOC:go_curators”

Added

glycine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of glycine.”
- database_cross_reference “GOC:curators”
glycine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI

glycine dehydrogenase (cytochrome) activity `http://purl.obolibrary.org/obo/GO_0047959`

Removed

glycine dehydrogenase (cytochrome) activity definition “Catalysis of the reaction: glycine + H2O + 2 ferricytochrome c = glyoxylate + NH3 + 2 ferrocytochrome c.”
- database_cross_reference “MetaCyc:GLYCINE-DEHYDROGENASE-CYTOCHROME-RXN”
- database_cross_reference “EC:1.4.2.1”

Added

glycine dehydrogenase (cytochrome) activity definition “Catalysis of the reaction: 2 Fe(III)-[cytochrome c] + glycine + H2O = 2 Fe(II)-[cytochrome c] + glyoxylate + NH4+ + 2 H+.”
- database_cross_reference “RHEA:16909”

glycine metabolic process `http://purl.obolibrary.org/obo/GO_0006544`

Removed

glycine metabolic process definition “The chemical reactions and pathways involving glycine, aminoethanoic acid.”
- database_cross_reference “GOC:go_curators”

Added

glycine metabolic process definition “The chemical reactions and pathways involving glycine, aminoethanoic acid.”
- database_cross_reference “GOC:curators”

glycine oxidase activity `http://purl.obolibrary.org/obo/GO_0043799`

Removed

glycine oxidase activity definition “Catalysis of the reactions: (1) glycine + H2O + O2 = glyoxylate + NH3 + hydrogen peroxide; (2) D-alanine + H2O + O2 = pyruvate + NH3 + hydrogen peroxide; (3) sarcosine + H2O + O2 = glyoxylate + methylamine + hydrogen peroxide; (4) N-ethylglycine + H2O + O2 = glyoxylate + ethylamine + hydrogen peroxide.”
- database_cross_reference “EC:1.4.3.19”

Added

glycine oxidase activity definition “Catalysis of the reactions: (1) glycine + H2O + O2 = glyoxylate + NH4+ + H2O2; (2) D-alanine + H2O + O2 = pyruvate + NH4+ + H2O2; (3) sarcosine + H2O + O2 = glyoxylate + methylamine + H2O2; (4) N-ethylglycine + H2O + O2 = glyoxylate + ethylamine + H2O2.”
- database_cross_reference “EC:1.4.3.19”

glycine:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0047958`

Removed

glycine:2-oxoglutarate transaminase activity label “glycine:2-oxoglutarate aminotransferase activity”
glycine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate.”
- database_cross_reference “MetaCyc:GLYCINE-AMINOTRANSFERASE-RXN”
- database_cross_reference “EC:2.6.1.4”
glycine:2-oxoglutarate transaminase activity SubClassOf transaminase activity

Added

glycine:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
glycine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate.”
- database_cross_reference “RHEA:14089”
glycine:2-oxoglutarate transaminase activity label “glycine:2-oxoglutarate transaminase activity”
glycine:2-oxoglutarate transaminase activity has_exact_synonym “glycine:2-oxoglutarate aminotransferase activity”
glycine:2-oxoglutarate transaminase activity SubClassOf amino acid transaminase activity

glycine:oxaloacetate transaminase activity `http://purl.obolibrary.org/obo/GO_0047303`

Removed

glycine:oxaloacetate transaminase activity label “glycine-oxaloacetate transaminase activity”
glycine:oxaloacetate transaminase activity definition “Catalysis of the reaction: glycine + oxaloacetate = L-aspartate + glyoxylate.”
- database_cross_reference “EC:2.6.1.35”
- database_cross_reference “RHEA:17141”
glycine:oxaloacetate transaminase activity SubClassOf transaminase activity

Added

glycine:oxaloacetate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
glycine:oxaloacetate transaminase activity definition “Catalysis of the reaction: glycine + oxaloacetate = L-aspartate + glyoxylate.”
- database_cross_reference “RHEA:17141”
glycine:oxaloacetate transaminase activity has_exact_synonym “glycine-oxaloacetate transaminase activity”
glycine:oxaloacetate transaminase activity label “glycine:oxaloacetate transaminase activity”
glycine:oxaloacetate transaminase activity SubClassOf amino acid transaminase activity

glycolate catabolic process `http://purl.obolibrary.org/obo/GO_0046296`

Added

glycolate catabolic process broadMatch GLYOXDEG-PWY
glycolate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
glycolate catabolic process broadMatch GLYCOLATEMET-PWY
glycolate catabolic process broadMatch PWY-8576

glycolate metabolic process `http://purl.obolibrary.org/obo/GO_0009441`

Removed

glycolate metabolic process database_cross_reference “MetaCyc:GLYCOLATEMET-PWY”

glycolate oxidase complex `http://purl.obolibrary.org/obo/GO_0009339`

Removed

glycolate oxidase complex definition “An enzyme complex that catalyzes the oxidation of 2-hydroxy acid to form 2-oxo acid and hydrogen peroxide (H2O2). The enzyme is a flavoprotein (FMN).”
- database_cross_reference “PMID:4557653”
- database_cross_reference “PMID:8606183”

Added

glycolate oxidase complex definition “An enzyme complex that catalyzes the oxidation of 2-hydroxy acid to form 2-oxo acid and H2O2. The enzyme is a flavoprotein (FMN).”
- database_cross_reference “PMID:4557653”
- database_cross_reference “PMID:8606183”

glycolipid biosynthetic process `http://purl.obolibrary.org/obo/GO_0009247`

Removed

glycolipid biosynthetic process database_cross_reference “MetaCyc:PWY-401”
glycolipid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide).”
- database_cross_reference “GOC:go_curators”

Added

glycolipid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide).”
- database_cross_reference “GOC:curators”

glycolipid catabolic process `http://purl.obolibrary.org/obo/GO_0019377`

Removed

glycolipid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide).”
- database_cross_reference “GOC:go_curators”

Added

glycolipid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide).”
- database_cross_reference “GOC:curators”

glycolipid translocation `http://purl.obolibrary.org/obo/GO_0034203`

Removed

glycolipid translocation definition “The translocation, or flipping, of glycolipid molecules from one monolayer of a membrane bilayer to the opposite monolayer.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:11807558”

Added

glycolipid translocation definition “The translocation, or flipping, of glycolipid molecules from one monolayer of a membrane bilayer to the opposite monolayer.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:11807558”

glycopeptide catabolic process `http://purl.obolibrary.org/obo/GO_0009050`

Removed

glycopeptide catabolic process definition “The chemical reactions and pathways resulting in the breakdown of glycopeptides, a compound in which carbohydrate is covalently attached to an oligopeptide composed of residues of L and/or D-amino acids. The term usually denotes a product of proteolytic degradation of a glycoprotein but includes glycated peptide.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

glycopeptide catabolic process definition “The chemical reactions and pathways resulting in the breakdown of glycopeptides, a compound in which carbohydrate is covalently attached to an oligopeptide composed of residues of L and/or D-amino acids. The term usually denotes a product of proteolytic degradation of a glycoprotein but includes glycated peptide.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

glycoprotein catabolic process `http://purl.obolibrary.org/obo/GO_0006516`

Removed

glycoprotein catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

glycoprotein catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

glycoprotein metabolic process `http://purl.obolibrary.org/obo/GO_0009100`

Removed

glycoprotein metabolic process definition “The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

glycoprotein metabolic process definition “The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity `http://purl.obolibrary.org/obo/GO_0004380`

Added

glycosaminoglycan catabolic process `http://purl.obolibrary.org/obo/GO_0006027`

Removed

glycosaminoglycan catabolic process database_cross_reference “Reactome:R-HSA-2024101”
- label “CS/DS degradation”

glycosaminoglycan-protein linkage region biosynthetic process `http://purl.obolibrary.org/obo/GO_0120532`

Added

glycosaminoglycan-protein linkage region biosynthetic process database_cross_reference “Reactome:R-HSA-1971475”
- label “Glycosaminoglycan-protein linkage region biosynthesis”

glycoside biosynthetic process `http://purl.obolibrary.org/obo/GO_0016138`

Removed

glycoside biosynthetic process definition “The chemical reactions and pathways resulting in the formation of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound.”
- database_cross_reference “GOC:go_curators”

Added

glycoside biosynthetic process definition “The chemical reactions and pathways resulting in the formation of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound.”
- database_cross_reference “GOC:curators”

glycoside catabolic process `http://purl.obolibrary.org/obo/GO_0016139`

Removed

glycoside catabolic process definition “The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound.”
- database_cross_reference “GOC:go_curators”

Added

glycoside catabolic process definition “The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound.”
- database_cross_reference “GOC:curators”

glycyl-radical enzyme activating activity `http://purl.obolibrary.org/obo/GO_0043364`

Added

glycyl-radical enzyme activating activity narrowMatch 19225
glycyl-radical enzyme activating activity database_cross_reference “RHEA:19225”

glyoxylate catabolic process `http://purl.obolibrary.org/obo/GO_0009436`

Removed

glyoxylate catabolic process database_cross_reference “MetaCyc:GLYOXDEG-PWY”

Added

glyoxylate catabolic process broadMatch GLYOXDEG-PWY
glyoxylate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
glyoxylate catabolic process broadMatch GLYCOLATEMET-PWY
glyoxylate catabolic process broadMatch PWY-8576

guanine biosynthetic process `http://purl.obolibrary.org/obo/GO_0046099`

Removed

guanine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important.”
- database_cross_reference “GOC:go_curators”

Added

guanine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important.”
- database_cross_reference “GOC:curators”

guanine catabolic process `http://purl.obolibrary.org/obo/GO_0006147`

Removed

guanine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important.”
- database_cross_reference “GOC:go_curators”

Added

guanine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important.”
- database_cross_reference “GOC:curators”

guanine deaminase activity `http://purl.obolibrary.org/obo/GO_0008892`

Removed

guanine deaminase activity definition “Catalysis of the reaction: guanine + H2O = xanthine + NH3.”
- database_cross_reference “EC:3.5.4.3”

Added

guanine deaminase activity definition “Catalysis of the reaction: guanine + H2O + H+ = xanthine + NH4+.”
- database_cross_reference “RHEA:14665”

guanine metabolic process `http://purl.obolibrary.org/obo/GO_0046098`

Removed

guanine metabolic process definition “The chemical reactions and pathways involving guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important.”
- database_cross_reference “GOC:go_curators”

Added

guanine metabolic process definition “The chemical reactions and pathways involving guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important.”
- database_cross_reference “GOC:curators”

guanine transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015208`

Removed

guanine transmembrane transporter activity definition “Enables the transfer of guanine, 2-amino-6-hydroxypurine, from one side of a membrane to the other.”
- database_cross_reference “GOC:go_curators”

Added

guanine transmembrane transporter activity definition “Enables the transfer of guanine, 2-amino-6-hydroxypurine, from one side of a membrane to the other.”
- database_cross_reference “GOC:curators”

guanine transport `http://purl.obolibrary.org/obo/GO_0015854`

Removed

guanine transport definition “The directed movement of guanine, 2-amino-6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:go_curators”

Added

guanine transport definition “The directed movement of guanine, 2-amino-6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:curators”

guanosine biosynthetic process `http://purl.obolibrary.org/obo/GO_0046114`

Removed

guanosine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of guanine, guanine riboside, a nucleoside with a wide species distribution.”
- database_cross_reference “GOC:go_curators”

Added

guanosine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of guanine, guanine riboside, a nucleoside with a wide species distribution.”
- database_cross_reference “GOC:curators”

guanosine catabolic process `http://purl.obolibrary.org/obo/GO_0046115`

Removed

guanosine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of guanine, guanine riboside, a nucleoside with a wide species distribution.”
- database_cross_reference “GOC:go_curators”

Added

guanosine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of guanine, guanine riboside, a nucleoside with a wide species distribution.”
- database_cross_reference “GOC:curators”

guanosine deaminase activity `http://purl.obolibrary.org/obo/GO_0047974`

Removed

guanosine deaminase activity definition “Catalysis of the reaction: guanosine + H2O = xanthosine + NH3.”
- database_cross_reference “EC:3.5.4.15”
- database_cross_reference “MetaCyc:GUANOSINE-DEAMINASE-RXN”

Added

guanosine deaminase activity definition “Catalysis of the reaction: guanosine + H2O + H+ = xanthosine + NH4+.”
- database_cross_reference “RHEA:12861”

guanyl-nucleotide exchange factor activity `http://purl.obolibrary.org/obo/GO_0005085`

Added

guanyl-nucleotide exchange factor activity database_cross_reference “Reactome:R-HSA-381727”
- label “RAP1A exchanges GDP for GTP”
guanyl-nucleotide exchange factor activity database_cross_reference “Reactome:R-HSA-400037”
- label “Gi,Go Heterotrimeric G-protein complex dissociates”

guanylylpyridinol adenylase activity `http://purl.obolibrary.org/obo/GO_0160301`

Removed

guanylylpyridinol adenylase activity definition “Catalysis of the reaction: guanylylpyridinol + ATP + H+ = guanylylpyridinol-AMP + diphosphate.”
- database_cross_reference “PMID:25882909”

Added

guanylylpyridinol adenylase activity definition “Catalysis of the reaction: guanylylpyridinol + ATP + H+ = guanylylpyridinol-AMP + diphosphate.”
- database_cross_reference “RHEA:85487”
- database_cross_reference “PMID:25882909”
guanylylpyridinol adenylase activity database_cross_reference “EC:2.7.7.110”
guanylylpyridinol adenylase activity exactMatch 2.7.7.110
guanylylpyridinol adenylase activity database_cross_reference “RHEA:85487”
guanylylpyridinol adenylase activity exactMatch 85487

gynoecium development `http://purl.obolibrary.org/obo/GO_0048467`

Removed

gynoecium development definition “The process whose specific outcome is the progression of the gynoecium over time, from its formation to the mature structure. The gynoecium is the collective name for the carpels of a flower.”
- database_cross_reference “PO:0008062”
- database_cross_reference “GOC:go_curators”

Added

gynoecium development definition “The process whose specific outcome is the progression of the gynoecium over time, from its formation to the mature structure. The gynoecium is the collective name for the carpels of a flower.”
- database_cross_reference “PO:0008062”
- database_cross_reference “GOC:curators”

hair cycle `http://purl.obolibrary.org/obo/GO_0042633`

Removed

hair cycle definition “The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body.”
- database_cross_reference “PMID:12230507”
- database_cross_reference “GOC:go_curators”

Added

hair cycle definition “The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body.”
- database_cross_reference “PMID:12230507”
- database_cross_reference “GOC:curators”

haloacetate dehalogenase activity `http://purl.obolibrary.org/obo/GO_0018785`

Added

haloacetate dehalogenase activity database_cross_reference “RHEA:30051”
haloacetate dehalogenase activity database_cross_reference “RHEA:25189”
haloacetate dehalogenase activity narrowMatch 25189
haloacetate dehalogenase activity narrowMatch 30051

halogenase activity `http://purl.obolibrary.org/obo/GO_0140906`

Added

halogenase activity database_cross_reference “Reactome:R-HSA-209925”
- label “DIT and MIT combine to form triiodothyronine”
halogenase activity database_cross_reference “Reactome:R-HSA-209840”
- label “Two DITs combine to form thyroxine”
halogenase activity database_cross_reference “Reactome:R-HSA-350901”
- label “Iodide is organified”
halogenase activity database_cross_reference “Reactome:R-HSA-209973”
- label “Tyrosine is diiodinated”
halogenase activity database_cross_reference “Reactome:R-HSA-209815”
- label “Tyrosine is monoiodinated”

hedgehog receptor activity `http://purl.obolibrary.org/obo/GO_0008158`

Removed

hedgehog receptor activity definition “Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity.”
- database_cross_reference “PMID:9278137”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:go_curators”

Added

hedgehog receptor activity definition “Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:9278137”
- database_cross_reference “GOC:bf”

helicase activity `http://purl.obolibrary.org/obo/GO_0004386`

Added

helicase activity database_cross_reference “Reactome:R-HSA-9923073”
- label “NS3 unwinds dsRNA secondary structures”
helicase activity database_cross_reference “Reactome:R-HSA-9922957”
- label “NS3 melts (+)-RNA secondary structures”

heme A synthase activity `http://purl.obolibrary.org/obo/GO_0120547`

Added

heme A synthase activity database_cross_reference “Reactome:R-HSA-2995334”
- label “COX15 transforms heme O to heme A”

heme B biosynthetic process `http://purl.obolibrary.org/obo/GO_0006785`

Added

heme B biosynthetic process narrowMatch PWY-7766
heme B biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
heme B biosynthetic process database_cross_reference “MetaCyc:PWY-7552”
heme B biosynthetic process narrowMatch HEME-BIOSYNTHESIS-II
heme B biosynthetic process database_cross_reference “MetaCyc:HEME-BIOSYNTHESIS-II-1”
heme B biosynthetic process database_cross_reference “MetaCyc:PWY-7766”
heme B biosynthetic process narrowMatch PWY-7552
heme B biosynthetic process database_cross_reference “MetaCyc:HEME-BIOSYNTHESIS-II”
heme B biosynthetic process narrowMatch HEME-BIOSYNTHESIS-II-1
heme B biosynthetic process narrowMatch HEMESYN2-PWY
heme B biosynthetic process database_cross_reference “MetaCyc:HEMESYN2-PWY”

heme B catabolic process `http://purl.obolibrary.org/obo/GO_1900548`

Added

heme B catabolic process narrowMatch PWY-7847
heme B catabolic process narrowMatch PWY-7846
heme B catabolic process database_cross_reference “MetaCyc:PWY-7846”
heme B catabolic process narrowMatch PWY-7848
heme B catabolic process narrowMatch PWY-7843
heme B catabolic process database_cross_reference “MetaCyc:PWY-7845”
heme B catabolic process database_cross_reference “MetaCyc:PWY-7848”
heme B catabolic process narrowMatch PWY-7844
heme B catabolic process narrowMatch PWY-7845
heme B catabolic process narrowMatch PWY-5874
heme B catabolic process database_cross_reference “MetaCyc:PWY-7843”
heme B catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
heme B catabolic process database_cross_reference “MetaCyc:PWY-7844”
heme B catabolic process database_cross_reference “MetaCyc:PWY-7847”

heme binding `http://purl.obolibrary.org/obo/GO_0020037`

Added

heme binding database_cross_reference “Reactome:R-HSA-9661419”
- label “ALB binds extracellular heme”

heme biosynthetic process `http://purl.obolibrary.org/obo/GO_0006783`

Removed

heme biosynthetic process database_cross_reference “MetaCyc:HEMESYN2-PWY”

heme export from vacuole to cytoplasm `http://purl.obolibrary.org/obo/GO_0140357`

Added

heme export from vacuole to cytoplasm SubClassOf intercellular transport

heme transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015232`

Added

heme transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9927930”
- label “DppBCDF transports heme to cytosol”
heme transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9927224”
- label “ChuA imports heme to periplasm”

hemoglobin metabolic process `http://purl.obolibrary.org/obo/GO_0020027`

Removed

hemoglobin metabolic process definition “The chemical reactions and pathways involving hemoglobin, including its uptake and utilization.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:go_curators”

Added

hemoglobin metabolic process definition “The chemical reactions and pathways involving hemoglobin, including its uptake and utilization.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:curators”

heparan sulfate 2-sulfotransferase activity `http://purl.obolibrary.org/obo/GO_0004394`

Removed

heparan sulfate 2-sulfotransferase activity database_cross_reference “Reactome:R-HSA-2076508”
- label “HS2ST1 sulfates IdoA at C2 in heparan sulfate”

Added

heparan sulfate 2-sulfotransferase activity database_cross_reference “Reactome:R-HSA-2076508”
- label “HS2ST1 trimer sulfates IdoA at C2 in heparan sulfate”

heparan sulfate proteoglycan metabolic process `http://purl.obolibrary.org/obo/GO_0030201`

Added

heparan sulfate proteoglycan metabolic process database_cross_reference “Reactome:R-HSA-1638091”
- label “Heparan sulfate/heparin (HS-GAG) metabolism”

hexagonal collagen network `http://purl.obolibrary.org/obo/GO_0098646`

Removed

hexagonal collagen network label “interstitial hexagonal collagen network”
hexagonal collagen network definition “A hexagonal shaped collagen network formed by collagen type X trimer, mostly found in the cartilage hyaline matrix, which located in the interstitial area.”
- database_cross_reference “PMID:21421911”
- database_cross_reference “PMID:34948124”

Added

hexagonal collagen network has_narrow_synonym “hexagonal collagen network of basement membrane”
hexagonal collagen network has_narrow_synonym “basement membrane hexagonal collagen network”
hexagonal collagen network definition “A hexagonal-shaped collagen network formed by collagen type X trimer or collagen type VIII trimers. Collagen type X trimers are mostly found in the cartilage hyaline matrix, which is located in the interstitial area. Note that collagen type VIII has been found in the basement membrane, but the localization is not definitive.”
- database_cross_reference “PMID:21421911”
- database_cross_reference “PMID:3047147”
- database_cross_reference “PMID:31387942”
- database_cross_reference “PMID:34948124”
hexagonal collagen network has_narrow_synonym “interstitial hexagonal collagen network”
hexagonal collagen network label “hexagonal collagen network”
hexagonal collagen network term tracker item “https://github.com/geneontology/go-ontology/issues/31494”^^anyURI

hindlimb morphogenesis `http://purl.obolibrary.org/obo/GO_0035137`

Removed

hindlimb morphogenesis definition “The process in which the anatomical structures of the hindlimb are generated and organized.”
- database_cross_reference “GOC:go_curators”

Added

hindlimb morphogenesis definition “The process in which the anatomical structures of the hindlimb are generated and organized.”
- database_cross_reference “GOC:curators”

histidine ammonia-lyase activity `http://purl.obolibrary.org/obo/GO_0004397`

Removed

histidine ammonia-lyase activity definition “Catalysis of the reaction: L-histidine = urocanate + NH3.”
- database_cross_reference “EC:4.3.1.3”

Added

histidine ammonia-lyase activity definition “Catalysis of the reaction: L-histidine = trans-urocanate + NH4+.”
- database_cross_reference “RHEA:21232”

histone H3K27 methyltransferase activity `http://purl.obolibrary.org/obo/GO_0046976`

Added

histone H3K27 methyltransferase activity database_cross_reference “Reactome:R-HSA-9764932”
- label “PRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter”
histone H3K27 methyltransferase activity database_cross_reference “Reactome:R-HSA-9909631”
- label “Trimethylation of CD274 gene promoter by EZH2”

histone H3K4 methyltransferase activity `http://purl.obolibrary.org/obo/GO_0042800`

Removed

histone H3K4 methyltransferase activity database_cross_reference “Reactome:R-HSA-3364026”
- label “SET1 complex trimethylates H3K4 at the MYC gene”
histone H3K4 methyltransferase activity database_cross_reference “Reactome:R-HSA-9843121”
- label “KMT2D,(KMT2C) complex monomethylates nucleosomes at PPARG:RXRA-bound enhancers”

Added

histone H3K4 methyltransferase activity database_cross_reference “Reactome:R-HSA-9843121”
- label “MLL4-ASCOM, (MLL3-ASCOM) complex monomethylates nucleosomes at PPARG:RXRA-bound enhancers”
histone H3K4 methyltransferase activity database_cross_reference “Reactome:R-HSA-9909628”
- label “Trimethylation of CD274 gene chromatin by MLL1/3 complex”
histone H3K4 methyltransferase activity database_cross_reference “Reactome:R-HSA-3364026”
- label “MLL2 complex trimethylates H3K4 at the MYC gene”

histone H3K56 methyltransferase activity `http://purl.obolibrary.org/obo/GO_0140759`

Removed

histone H3K56 methyltransferase activity definition “Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 56) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 56). This reaction is the addition of a methyl group to the lysine residue at position 56 of the histone H3 protein.”
- database_cross_reference “PMID:28743002”
- database_cross_reference “PMID:23451023”

Added

histone H3K56 methyltransferase activity exactMatch 85519
histone H3K56 methyltransferase activity database_cross_reference “RHEA:85519”
histone H3K56 methyltransferase activity definition “Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 56) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 56). This reaction is the addition of a methyl group to the lysine residue at position 56 of the histone H3 protein.”
- database_cross_reference “PMID:28743002”
- database_cross_reference “RHEA:85519”
- database_cross_reference “PMID:23451023”

histone H3K56me2/H3K56me3 demethylase activity `http://purl.obolibrary.org/obo/GO_0140760`

Added

histone H4K20 demethylase activity `http://purl.obolibrary.org/obo/GO_0035575`

Added

histone H4K20 demethylase activity narrowMatch 85911
histone H4K20 demethylase activity database_cross_reference “RHEA:85907”
histone H4K20 demethylase activity narrowMatch 85907
histone H4K20 demethylase activity database_cross_reference “RHEA:85911”

histone acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0004402`

Added

histone acetyltransferase activity database_cross_reference “Reactome:R-HSA-9926482”
- label “CREBBP, EP300 acetylate MITF-M”

histone dopaminyltransferase activity `http://purl.obolibrary.org/obo/GO_0120297`

Removed

histone dopaminyltransferase activity definition “Catalysis of the reaction: dopamine + L-glutaminyl-[histone] = 5-dopaminyl-L-glutamyl-[histone] + NH4(+).”
- database_cross_reference “PMID:32273471”
- database_cross_reference “GOC:sp”

Added

histone dopaminyltransferase activity definition “Catalysis of the reaction: dopamine + L-glutaminyl-[histone] = 5-dopaminyl-L-glutamyl-[histone] + NH4+.”
- database_cross_reference “PMID:32273471”
- database_cross_reference “GOC:sp”

histone serotonyltransferase activity `http://purl.obolibrary.org/obo/GO_0120295`

Removed

histone serotonyltransferase activity definition “Catalysis of the reaction: L-glutaminyl-[histone] + serotonin = 5-serotonyl-L-glutamyl-[histone] + NH4(+).”
- database_cross_reference “PMID:30867594”
- database_cross_reference “GOC:sp”

Added

histone serotonyltransferase activity definition “Catalysis of the reaction: L-glutaminyl-[histone] + serotonin = 5-serotonyl-L-glutamyl-[histone] + NH4+.”
- database_cross_reference “PMID:30867594”
- database_cross_reference “GOC:sp”

holo-[acyl-carrier-protein] synthase activity `http://purl.obolibrary.org/obo/GO_0008897`

Added

homocysteine desulfhydrase activity `http://purl.obolibrary.org/obo/GO_0047982`

Removed

homocysteine desulfhydrase activity definition “Catalysis of the reaction: L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate.”
- database_cross_reference “MetaCyc:HOMOCYSTEINE-DESULFHYDRASE-RXN”
- database_cross_reference “EC:4.4.1.2”

Added

homocysteine desulfhydrase activity definition “Catalysis of the reaction: L-homocysteine + H2O = 2-oxobutanoate + hydrogen sulfide + NH4+ + H+.”
- database_cross_reference “RHEA:14501”

homogentisate farnesyltransferase activity `http://purl.obolibrary.org/obo/GO_0010355`

Removed

homogentisate farnesyltransferase activity comment “The reason for obsoletion is that the data from the paper for which the term was requested can be accurately described using homogentisate solanesyltransferase activity.”
homogentisate farnesyltransferase activity label “obsolete homogentisate farnesyltransferase activity”
homogentisate farnesyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/29344”^^anyURI
homogentisate farnesyltransferase activity definition “OBSOLETE. Catalysis of the reaction: homogentisic acid + farnesyl diphosphate = 2-methyl-6-farnesylplastoquinol.”
- database_cross_reference “PMID:16989822”
homogentisate farnesyltransferase activity deprecated true

Added

homogentisate farnesyltransferase activity label “homogentisate farnesyltransferase activity”
homogentisate farnesyltransferase activity definition “Catalysis of the reaction: homogentisic acid + farnesyl diphosphate = 2-methyl-6-farnesylplastoquinol.”
- database_cross_reference “PMID:16989822”
homogentisate farnesyltransferase activity SubClassOf homogentisate prenyltransferase activity

homomethionine N-monooxygenase activity `http://purl.obolibrary.org/obo/GO_0120526`

Added

homomethionine N-monooxygenase activity database_cross_reference “RHEA:33291”
homomethionine N-monooxygenase activity narrowMatch 32719
homomethionine N-monooxygenase activity narrowMatch 32723
homomethionine N-monooxygenase activity database_cross_reference “RHEA:32719”
homomethionine N-monooxygenase activity narrowMatch 33243
homomethionine N-monooxygenase activity narrowMatch 33291
homomethionine N-monooxygenase activity database_cross_reference “RHEA:33243”
homomethionine N-monooxygenase activity database_cross_reference “RHEA:33295”
homomethionine N-monooxygenase activity database_cross_reference “RHEA:32723”
homomethionine N-monooxygenase activity narrowMatch 33295

homospermidine synthase (spermidine-specific) activity `http://purl.obolibrary.org/obo/GO_0050514`

Removed

homospermidine synthase (spermidine-specific) activity definition “Catalysis of the reaction: spermidine + putrescine = sym-homospermidine + propane-1,3-diamine.”
- database_cross_reference “EC:2.5.1.45”

Added

homospermidine synthase (spermidine-specific) activity definition “Catalysis of the reaction: spermidine + putrescine = sym-homospermidine + propane-1,3-diamine.”
- database_cross_reference “RHEA:11236”

homospermidine synthase activity `http://purl.obolibrary.org/obo/GO_0047296`

Removed

homospermidine synthase activity database_cross_reference “EC:2.5.1.44”
homospermidine synthase activity definition “Catalysis of the reaction: 2 putrescine = NH3 + sym-homospermidine.”
- database_cross_reference “EC:2.5.1.44”
homospermidine synthase activity exactMatch 2.5.1.44

Added

homospermidine synthase activity broadMatch 2.5.1.44
homospermidine synthase activity definition “Catalysis of the reaction: 2 putrescine = sym-homospermidine + NH4+.”
- database_cross_reference “RHEA:18645”

host extracellular region `http://purl.obolibrary.org/obo/GO_0043655`

Removed

host extracellular region label “host extracellular space”
host extracellular region definition “The space within a host but external to the plasma membrane of host cells, e.g. within host bloodstream.”
- database_cross_reference “GOC:cc”

Added

host extracellular region label “host extracellular region”
host extracellular region has_exact_synonym “host extracellular space”
host extracellular region term tracker item “https://github.com/geneontology/go-ontology/issues/31545”^^anyURI
host extracellular region definition “The space within a host but external to the plasma membrane of host cells, e.g. host bloodstream.”
- database_cross_reference “GOC:cc”

hyaluronan biosynthetic process `http://purl.obolibrary.org/obo/GO_0030213`

Removed

hyaluronan biosynthetic process database_cross_reference “Reactome:R-HSA-2142850”
- label “Hyaluronan biosynthesis and export”

hyaluronan catabolic process `http://purl.obolibrary.org/obo/GO_0030214`

Removed

hyaluronan catabolic process database_cross_reference “Reactome:R-HSA-2160916”
- label “Hyaluronan uptake and degradation”

Added

hyaluronan catabolic process database_cross_reference “Reactome:R-HSA-2160916”
- label “Hyaluronan degradation”

hyaluronan synthase activity `http://purl.obolibrary.org/obo/GO_0050501`

Removed

hyaluronan synthase activity database_cross_reference “Reactome:R-HSA-2160851”
- label “HAS1,2,3 mediate the polymerization of HA”

Added

hyaluronan synthase activity database_cross_reference “Reactome:R-HSA-2160851”
- label “HAS1,2,3 mediate the polymerization and export of HA”

hyaluronic acid binding `http://purl.obolibrary.org/obo/GO_0005540`

Removed

hyaluronic acid binding SubClassOf glycosaminoglycan binding

Added

hyaluronic acid binding SubClassOf carboxylic acid binding

hyalurononglucosaminidase activity `http://purl.obolibrary.org/obo/GO_0004415`

Removed

hyalurononglucosaminidase activity database_cross_reference “Reactome:R-HSA-5693356”
- label “CEMIP hydrolyses HA”
hyalurononglucosaminidase activity database_cross_reference “Reactome:R-HSA-1793209”
- label “HYAL1 hydrolyses Chondroitin chains”
hyalurononglucosaminidase activity database_cross_reference “Reactome:R-HSA-2160892”
- label “Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments”

Added

hyalurononglucosaminidase activity database_cross_reference “Reactome:R-HSA-1793209”
- label “HYAL1-4 hydrolyze chondroitin chains”
hyalurononglucosaminidase activity database_cross_reference “Reactome:R-HSA-2160892”
- label “HYAL2 hydrolyses HA into 20kDa fragments”
hyalurononglucosaminidase activity database_cross_reference “Reactome:R-HSA-5693356”
- label “CEMIP hydrolyzes HA”
hyalurononglucosaminidase activity database_cross_reference “Reactome:R-HSA-9941055”
- label “SPAM1 randomly cleaves HA”

hydantoin racemase activity `http://purl.obolibrary.org/obo/GO_0036348`

Added

hydantoin racemase activity database_cross_reference “RHEA:84231”
hydantoin racemase activity database_cross_reference “RHEA:83991”
hydantoin racemase activity database_cross_reference “RHEA:84227”
hydantoin racemase activity narrowMatch 83991
hydantoin racemase activity narrowMatch 83951
hydantoin racemase activity narrowMatch 84227
hydantoin racemase activity database_cross_reference “RHEA:83951”
hydantoin racemase activity narrowMatch 84231

hydro-lyase activity `http://purl.obolibrary.org/obo/GO_0016836`

Removed

hydro-lyase activity database_cross_reference “Reactome:R-HSA-9014627”
- label “SDS dimers:PXLP dehydrate L-Thr to 2AA”

hydrogen peroxide channel activity `http://purl.obolibrary.org/obo/GO_0140070`

Removed

hydrogen peroxide channel activity definition “Enables the energy-independent facilitated diffusion of hydrogen peroxide through a transmembrane aqueous pore or channel.”
- database_cross_reference “PMID:23541115”
- database_cross_reference “PMID:27256569”

Added

hydrogen peroxide channel activity definition “Enables the energy-independent facilitated diffusion of H2O2 through a transmembrane aqueous pore or channel.”
- database_cross_reference “PMID:23541115”
- database_cross_reference “PMID:27256569”

hydrogen peroxide transmembrane transport `http://purl.obolibrary.org/obo/GO_0080170`

Removed

hydrogen peroxide transmembrane transport definition “The process in which hydrogen peroxide is transported across a membrane.”
- database_cross_reference “GOC:tb”

Added

hydrogen peroxide transmembrane transport definition “The process in which H2O2 is transported across a membrane.”
- database_cross_reference “GOC:tb”

hydrolase activity `http://purl.obolibrary.org/obo/GO_0016787`

Added

hydrolase activity database_cross_reference “Reactome:R-HSA-9942295”
- label “QNG1 hydrolyzes queuosine 5’-monophosphate yielding queuine and ribose 5’-monophosphate”

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides `http://purl.obolibrary.org/obo/GO_0016812`

Removed

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides database_cross_reference “Reactome:R-HSA-70906”
- label “4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+”

Added

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides database_cross_reference “Reactome:R-HSA-70906”
- label “4-imidazolone-5-propanoate + H2O => N-formiminoglutamate”

hydrolase activity, acting on glycosyl bonds `http://purl.obolibrary.org/obo/GO_0016798`

Added

hydrolase activity, acting on glycosyl bonds database_cross_reference “Reactome:R-HSA-5333609”
- label “MeSebGalNac is hydrolysed to MeSeH and bGalNac”

hydroperoxy icosatetraenoate dehydratase activity `http://purl.obolibrary.org/obo/GO_0106256`

Added

hydroperoxy icosatetraenoate isomerase activity `http://purl.obolibrary.org/obo/GO_0106255`

Added

hydroperoxy icosatetraenoate isomerase activity database_cross_reference “RHEA:53400”
hydroperoxy icosatetraenoate isomerase activity database_cross_reference “RHEA:37951”
hydroperoxy icosatetraenoate isomerase activity narrowMatch 37951
hydroperoxy icosatetraenoate isomerase activity database_cross_reference “Reactome:R-HSA-8942208”
- label “ALOXE3 isomerises 12R-HpETE to HXA3”
hydroperoxy icosatetraenoate isomerase activity database_cross_reference “RHEA:41251”
hydroperoxy icosatetraenoate isomerase activity database_cross_reference “RHEA:37939”
hydroperoxy icosatetraenoate isomerase activity database_cross_reference “RHEA:53404”
hydroperoxy icosatetraenoate isomerase activity narrowMatch 37955
hydroperoxy icosatetraenoate isomerase activity narrowMatch 50216
hydroperoxy icosatetraenoate isomerase activity narrowMatch 41251
hydroperoxy icosatetraenoate isomerase activity narrowMatch 37931
hydroperoxy icosatetraenoate isomerase activity narrowMatch 37959
hydroperoxy icosatetraenoate isomerase activity database_cross_reference “RHEA:37955”
hydroperoxy icosatetraenoate isomerase activity database_cross_reference “RHEA:37931”
hydroperoxy icosatetraenoate isomerase activity database_cross_reference “Reactome:R-HSA-2161794”
- label “Arachidonate is converted to HXA3/B3 by ALOX12”
hydroperoxy icosatetraenoate isomerase activity database_cross_reference “RHEA:37959”
hydroperoxy icosatetraenoate isomerase activity narrowMatch 53404
hydroperoxy icosatetraenoate isomerase activity narrowMatch 53400
hydroperoxy icosatetraenoate isomerase activity narrowMatch 37939
hydroperoxy icosatetraenoate isomerase activity database_cross_reference “RHEA:50216”

hydroxyacylglutathione hydrolase activity `http://purl.obolibrary.org/obo/GO_0004416`

Added

hydroxyacylglutathione hydrolase activity database_cross_reference “RHEA:25245”
hydroxyacylglutathione hydrolase activity narrowMatch 25245

hydroxylamine reductase activity `http://purl.obolibrary.org/obo/GO_0050418`

Removed

hydroxylamine reductase activity definition “Catalysis of the reaction: NH3 + H2O + acceptor = hydroxylamine + reduced acceptor.”
- database_cross_reference “EC:1.7.99.1”

Added

hydroxylamine reductase activity definition “Catalysis of the reaction: an acceptor + NH4+ + H2O = hydroxylamine + a reduced acceptor + H+.”
- database_cross_reference “RHEA:22052”

hyphal cell wall `http://purl.obolibrary.org/obo/GO_0030446`

Removed

hyphal cell wall definition “The cell wall surrounding a fungal hypha.”
- database_cross_reference “GOC:mah”

Added

hyphal cell wall definition “The cell wall surrounding a fungal hypha.”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:36266346”

hypoxanthine biosynthetic process `http://purl.obolibrary.org/obo/GO_0046101`

Removed

hypoxanthine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate.”
- database_cross_reference “GOC:go_curators”

Added

hypoxanthine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate.”
- database_cross_reference “GOC:curators”

hypoxanthine metabolic process `http://purl.obolibrary.org/obo/GO_0046100`

Removed

hypoxanthine metabolic process definition “The chemical reactions and pathways involving hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate.”
- database_cross_reference “GOC:go_curators”

Added

hypoxanthine metabolic process definition “The chemical reactions and pathways involving hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate.”
- database_cross_reference “GOC:curators”

immunoglobulin complex, circulating `http://purl.obolibrary.org/obo/GO_0042571`

Removed

immunoglobulin complex, circulating SubClassOf part of some obsolete extracellular space

Added

immunoglobulin complex, circulating SubClassOf extracellular protein-containing complex

import into nucleus `http://purl.obolibrary.org/obo/GO_0051170`

Added

import into nucleus SubClassOf intercellular transport

import into the mitochondrion `http://purl.obolibrary.org/obo/GO_0170036`

Added

import into the mitochondrion SubClassOf intercellular transport

importin-alpha family protein binding `http://purl.obolibrary.org/obo/GO_0061676`

Added

importin-alpha family protein binding database_cross_reference “Reactome:R-HSA-2065539”
- label “SREBP1A,1C,2:Importin beta-1 dissociates”

in utero embryonic development `http://purl.obolibrary.org/obo/GO_0001701`

Removed

in utero embryonic development definition “The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_sensu”

Added

in utero embryonic development definition “The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_sensu”

indole-3-acetonitrile nitrilase activity `http://purl.obolibrary.org/obo/GO_0080061`

Removed

indole-3-acetonitrile nitrilase activity definition “Catalysis of the reaction: indole-3-acetonitrile + 2 H2O = indole-3-acetic acid + NH3.”
- database_cross_reference “RHEA:45776”

Added

indole-3-acetonitrile nitrilase activity definition “Catalysis of the reaction: (indol-3-yl)acetonitrile + 2 H2O = (indol-3-yl)acetate + NH4+.”
- database_cross_reference “RHEA:45776”
indole-3-acetonitrile nitrilase activity broadMatch 3.5.5.1

inhibin complex `http://purl.obolibrary.org/obo/GO_0043511`

Removed

inhibin complex SubClassOf part of some obsolete extracellular space
inhibin complex SubClassOf protein-containing complex

Added

inhibin complex SubClassOf extracellular protein-containing complex

inosine biosynthetic process `http://purl.obolibrary.org/obo/GO_0046103`

Removed

inosine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs.”
- database_cross_reference “GOC:go_curators”

Added

inosine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs.”
- database_cross_reference “GOC:curators”

inosine catabolic process `http://purl.obolibrary.org/obo/GO_0006148`

Removed

inosine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs.”
- database_cross_reference “GOC:go_curators”

Added

inosine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs.”
- database_cross_reference “GOC:curators”

inosine metabolic process `http://purl.obolibrary.org/obo/GO_0046102`

Removed

inosine metabolic process definition “The chemical reactions and pathways involving inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs.”
- database_cross_reference “GOC:go_curators”

Added

inosine metabolic process definition “The chemical reactions and pathways involving inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs.”
- database_cross_reference “GOC:curators”

inositol 1,3,4,5 tetrakisphosphate binding `http://purl.obolibrary.org/obo/GO_0043533`

Removed

inositol 1,3,4,5 tetrakisphosphate binding definition “Binding to inositol 1,3,4,5 tetrakisphosphate.”
- database_cross_reference “GOC:go_curators”

Added

inositol 1,3,4,5 tetrakisphosphate binding definition “Binding to inositol 1,3,4,5 tetrakisphosphate.”
- database_cross_reference “GOC:curators”

inositol catabolic process `http://purl.obolibrary.org/obo/GO_0019310`

Removed

inositol catabolic process definition “The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms.”
- database_cross_reference “GOC:go_curators”

Added

inositol catabolic process narrowMatch P562-PWY
inositol catabolic process narrowMatch PWY-7241
inositol catabolic process definition “The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms.”
- database_cross_reference “GOC:curators”
inositol catabolic process database_cross_reference “MetaCyc:PWY-7241”
inositol catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI

inositol hexakisphosphate 3-phosphatase activity `http://purl.obolibrary.org/obo/GO_0016158`

Added

inositol hexakisphosphate 3-phosphatase activity database_cross_reference “Reactome:R-HSA-1855225”
- label “IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen”

inositol hexakisphosphate binding `http://purl.obolibrary.org/obo/GO_0000822`

Removed

inositol hexakisphosphate binding definition “Binding to inositol hexakisphosphate.”
- database_cross_reference “GOC:go_curators”

Added

inositol hexakisphosphate binding definition “Binding to inositol hexakisphosphate.”
- database_cross_reference “GOC:curators”

inositol monophosphate phosphatase activity `http://purl.obolibrary.org/obo/GO_0052834`

Added

inositol monophosphate phosphatase activity narrowMatch 44160
inositol monophosphate phosphatase activity database_cross_reference “RHEA:44156”
inositol monophosphate phosphatase activity database_cross_reference “RHEA:44152”
inositol monophosphate phosphatase activity narrowMatch 44156
inositol monophosphate phosphatase activity narrowMatch 44152
inositol monophosphate phosphatase activity database_cross_reference “RHEA:44160”

insulin-like growth factor binding protein complex `http://purl.obolibrary.org/obo/GO_0016942`

Removed

insulin-like growth factor binding protein complex SubClassOf part of some obsolete extracellular space

Added

insulin-like growth factor binding protein complex SubClassOf extracellular protein-containing complex

integrin biosynthetic process `http://purl.obolibrary.org/obo/GO_0045112`

Removed

integrin biosynthetic process definition “The chemical reactions and pathways resulting in the formation of integrins, a large family of transmembrane proteins that act as receptors for cell-adhesion molecules.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

integrin biosynthetic process definition “The chemical reactions and pathways resulting in the formation of integrins, a large family of transmembrane proteins that act as receptors for cell-adhesion molecules.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

intercellular transport `http://purl.obolibrary.org/obo/GO_0010496`

Added

intercellular transport term tracker item “https://github.com/geneontology/go-ontology/issues/31545”^^anyURI

interleukin-1 receptor binding `http://purl.obolibrary.org/obo/GO_0005149`

Removed

interleukin-1 receptor binding definition “Binding to an interleukin-1 receptor.”
- database_cross_reference “GOC:go_curators”

Added

interleukin-1 receptor binding definition “Binding to an interleukin-1 receptor.”
- database_cross_reference “GOC:curators”

interleukin-12 complex `http://purl.obolibrary.org/obo/GO_0043514`

Removed

interleukin-12 complex SubClassOf part of some obsolete extracellular space
interleukin-12 complex SubClassOf protein-containing complex

Added

interleukin-12 complex SubClassOf extracellular protein-containing complex

interleukin-16 receptor binding `http://purl.obolibrary.org/obo/GO_0045514`

Removed

interleukin-16 receptor binding definition “Binding to an interleukin-16 receptor.”
- database_cross_reference “GOC:go_curators”

Added

interleukin-16 receptor binding definition “Binding to an interleukin-16 receptor.”
- database_cross_reference “GOC:curators”

interleukin-18 receptor binding `http://purl.obolibrary.org/obo/GO_0045515`

Removed

interleukin-18 receptor binding definition “Binding to an interleukin-18 receptor.”
- database_cross_reference “GOC:go_curators”

Added

interleukin-18 receptor binding definition “Binding to an interleukin-18 receptor.”
- database_cross_reference “GOC:curators”

interleukin-19 receptor binding `http://purl.obolibrary.org/obo/GO_0045516`

Removed

interleukin-19 receptor binding definition “Binding to an interleukin-19 receptor.”
- database_cross_reference “GOC:go_curators”

Added

interleukin-19 receptor binding definition “Binding to an interleukin-19 receptor.”
- database_cross_reference “GOC:curators”

interleukin-20 receptor binding `http://purl.obolibrary.org/obo/GO_0045517`

Removed

interleukin-20 receptor binding definition “Binding to an interleukin-20 receptor.”
- database_cross_reference “GOC:go_curators”

Added

interleukin-20 receptor binding definition “Binding to an interleukin-20 receptor.”
- database_cross_reference “GOC:curators”

interleukin-22 receptor binding `http://purl.obolibrary.org/obo/GO_0045518`

Removed

interleukin-22 receptor binding definition “Binding to an interleukin-22 receptor.”
- database_cross_reference “GOC:go_curators”

Added

interleukin-22 receptor binding definition “Binding to an interleukin-22 receptor.”
- database_cross_reference “GOC:curators”

interleukin-23 complex `http://purl.obolibrary.org/obo/GO_0070743`

Removed

interleukin-23 complex SubClassOf part of some obsolete extracellular space
interleukin-23 complex SubClassOf protein-containing complex

Added

interleukin-23 complex SubClassOf extracellular protein-containing complex

interleukin-23 receptor binding `http://purl.obolibrary.org/obo/GO_0045519`

Removed

interleukin-23 receptor binding definition “Binding to an interleukin-23 receptor.”
- database_cross_reference “GOC:go_curators”

Added

interleukin-23 receptor binding definition “Binding to an interleukin-23 receptor.”
- database_cross_reference “GOC:curators”

interleukin-24 binding `http://purl.obolibrary.org/obo/GO_0045510`

Removed

interleukin-24 binding definition “Binding to interleukin-24.”
- database_cross_reference “GOC:go_curators”

Added

interleukin-24 binding definition “Binding to interleukin-24.”
- database_cross_reference “GOC:curators”

interleukin-24 receptor binding `http://purl.obolibrary.org/obo/GO_0045520`

Removed

interleukin-24 receptor binding definition “Binding to an interleukin-24 receptor.”
- database_cross_reference “GOC:go_curators”

Added

interleukin-24 receptor binding definition “Binding to an interleukin-24 receptor.”
- database_cross_reference “GOC:curators”

interleukin-25 binding `http://purl.obolibrary.org/obo/GO_0045511`

Removed

interleukin-25 binding definition “Binding to interleukin-25.”
- database_cross_reference “GOC:go_curators”

Added

interleukin-25 binding definition “Binding to interleukin-25.”
- database_cross_reference “GOC:curators”

interleukin-25 receptor binding `http://purl.obolibrary.org/obo/GO_0045521`

Removed

interleukin-25 receptor binding definition “Binding to an interleukin-25 receptor.”
- database_cross_reference “GOC:go_curators”

Added

interleukin-25 receptor binding definition “Binding to an interleukin-25 receptor.”
- database_cross_reference “GOC:curators”

interleukin-26 binding `http://purl.obolibrary.org/obo/GO_0045512`

Removed

interleukin-26 binding definition “Binding to interleukin-26.”
- database_cross_reference “GOC:go_curators”

Added

interleukin-26 binding definition “Binding to interleukin-26.”
- database_cross_reference “GOC:curators”

interleukin-26 receptor binding `http://purl.obolibrary.org/obo/GO_0045522`

Removed

interleukin-26 receptor binding definition “Binding to an interleukin-26 receptor.”
- database_cross_reference “GOC:go_curators”

Added

interleukin-26 receptor binding definition “Binding to an interleukin-26 receptor.”
- database_cross_reference “GOC:curators”

interleukin-27 binding `http://purl.obolibrary.org/obo/GO_0045513`

Removed

interleukin-27 binding definition “Binding to interleukin-27.”
- database_cross_reference “GOC:go_curators”

Added

interleukin-27 binding definition “Binding to interleukin-27.”
- database_cross_reference “GOC:curators”

interleukin-27 complex `http://purl.obolibrary.org/obo/GO_0070744`

Removed

interleukin-27 complex SubClassOf part of some obsolete extracellular space
interleukin-27 complex SubClassOf protein-containing complex

Added

interleukin-27 complex SubClassOf extracellular protein-containing complex

interleukin-27 receptor binding `http://purl.obolibrary.org/obo/GO_0045523`

Removed

interleukin-27 receptor binding definition “Binding to an interleukin-27 receptor.”
- database_cross_reference “GOC:go_curators”

Added

interleukin-27 receptor binding definition “Binding to an interleukin-27 receptor.”
- database_cross_reference “GOC:curators”

interleukin-35 complex `http://purl.obolibrary.org/obo/GO_0070745`

Removed

interleukin-35 complex SubClassOf protein-containing complex
interleukin-35 complex SubClassOf part of some obsolete extracellular space

Added

interleukin-35 complex SubClassOf extracellular protein-containing complex

interleukin-8 receptor binding `http://purl.obolibrary.org/obo/GO_0005153`

Removed

interleukin-8 receptor binding definition “Binding to an interleukin-8 receptor.”
- database_cross_reference “GOC:go_curators”

Added

interleukin-8 receptor binding definition “Binding to an interleukin-8 receptor.”
- database_cross_reference “GOC:curators”

intermediate mesoderm morphogenesis `http://purl.obolibrary.org/obo/GO_0048390`

Removed

intermediate mesoderm morphogenesis definition “The process in which the anatomical structures of the intermediate mesoderm are generated and organized.”
- database_cross_reference “GOC:go_curators”

Added

intermediate mesoderm morphogenesis definition “The process in which the anatomical structures of the intermediate mesoderm are generated and organized.”
- database_cross_reference “GOC:curators”

internal side of mycolate outer membrane `http://purl.obolibrary.org/obo/GO_0098569`

Removed

internal side of mycolate outer membrane definition “The side of the mycolate outer membrane that faces the cell wall peptidoglycan. It is rich in long-chain mycolic acids (hydroxylated branched-chain fatty acids) that are covalently linked to the cell wall peptidoglycan via an arabinogalactan network.”
- database_cross_reference “GOC:dos”
- database_cross_reference “PMID:18316738”
- database_cross_reference “PMID:18567661”

Added

internal side of mycolate outer membrane definition “The leaflet of the mycolate outer membrane that faces the cell wall peptidoglycan, including any protein embedded in, attached to, or peripherally associated with it. It is rich in long-chain mycolic acids (hydroxylated branched-chain fatty acids) that are covalently linked to the cell wall peptidoglycan via an arabinogalactan network.”
- database_cross_reference “GOC:dos”
- database_cross_reference “PMID:18316738”
- database_cross_reference “PMID:18567661”
internal side of mycolate outer membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI

intestinal lumen acidification `http://purl.obolibrary.org/obo/GO_7770055`

Added

intestinal lumen acidification has_exact_synonym “intestinal lumen pH reduction”
intestinal lumen acidification creation date “2026-03-03T02:00:57Z”
intestinal lumen acidification has_obo_namespace “biological_process”
intestinal lumen acidification id “GO:7770055”
intestinal lumen acidification definition “Any process that reduces the pH of the intestinal lumen, corresponding to an increase in hydrogen ion concentration.”
- database_cross_reference “PMID:19741196”
intestinal lumen acidification created by “dragon-ai-agent”
intestinal lumen acidification term tracker item “https://github.com/geneontology/go-ontology/issues/31657”^^anyURI
intestinal lumen acidification label “intestinal lumen acidification”
Class: intestinal lumen acidification
intestinal lumen acidification SubClassOf multicellular organismal-level extracellular fluid acidification

intracellular glucose homeostasis `http://purl.obolibrary.org/obo/GO_0001678`

Removed

intracellular glucose homeostasis definition “A homeostatic process involved in the maintenance of a steady state level of glucose within a cell.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

intracellular glucose homeostasis definition “A homeostatic process involved in the maintenance of a steady state level of glucose within a cell.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

intracellular membrane-bounded organelle `http://purl.obolibrary.org/obo/GO_0043231`

Removed

intracellular membrane-bounded organelle definition “Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.”
- database_cross_reference “GOC:go_curators”

Added

intracellular membrane-bounded organelle definition “Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.”
- database_cross_reference “GOC:curators”

intracellular membraneless organelle `http://purl.obolibrary.org/obo/GO_0043232`

Removed

intracellular membraneless organelle definition “Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.”
- database_cross_reference “GOC:go_curators”

Added

intracellular membraneless organelle definition “Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.”
- database_cross_reference “GOC:curators”

intracellular organelle `http://purl.obolibrary.org/obo/GO_0043229`

Removed

intracellular organelle definition “Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.”
- database_cross_reference “GOC:go_curators”

Added

intracellular organelle definition “Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.”
- database_cross_reference “GOC:curators”

intracellular pH elevation `http://purl.obolibrary.org/obo/GO_0051454`

Removed

intracellular pH elevation definition “Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion.”
- database_cross_reference “GOC:ai”

Added

intracellular pH elevation definition “Any process that increases the internal pH of a cell, corresponding to a decrease in hydrogen ion concentration.”
- database_cross_reference “GOC:ai”

intracellular pH reduction `http://purl.obolibrary.org/obo/GO_0051452`

Removed

intracellular pH reduction definition “Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion.”
- database_cross_reference “GOC:ai”

Added

intracellular pH reduction definition “Any process that reduces the internal pH of a cell, corresponding to an increase in hydrogen ion concentration.”
- database_cross_reference “GOC:ai”

intramembrane lipid carrier activity `http://purl.obolibrary.org/obo/GO_0140303`

Removed

intramembrane lipid carrier activity label “intramembrane lipid transporter activity”

Added

intramembrane lipid carrier activity term tracker item “https://github.com/geneontology/go-ontology/issues/31454”^^anyURI
intramembrane lipid carrier activity has_broad_synonym “intramembrane lipid transporter activity”
intramembrane lipid carrier activity label “intramembrane lipid carrier activity”
intramembrane lipid carrier activity SubClassOf transporter activity

intramolecular oxidoreductase activity, transposing C=C bonds `http://purl.obolibrary.org/obo/GO_0016863`

Added

intramolecular oxidoreductase activity, transposing C=C bonds database_cross_reference “Reactome:R-HSA-2161563”
- label “PGJ2 is isomerised to delta12-PGJ2”

intrinsic apoptotic signaling pathway in response to DNA damage `http://purl.obolibrary.org/obo/GO_0008630`

Removed

intrinsic apoptotic signaling pathway in response to DNA damage definition “The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_apoptosis”

Added

intrinsic apoptotic signaling pathway in response to DNA damage definition “The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_apoptosis”

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator `http://purl.obolibrary.org/obo/GO_0042771`

Removed

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator definition “The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_apoptosis”

Added

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator definition “The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_apoptosis”

iodide peroxidase activity `http://purl.obolibrary.org/obo/GO_0004447`

Removed

iodide peroxidase activity definition “Catalysis of the reaction: iodide + H2O2 = iodine + 2 H2O.”
- database_cross_reference “RHEA:23336”
iodide peroxidase activity exactMatch 23336

Added

iodide peroxidase activity database_cross_reference “RHEA:48960”
iodide peroxidase activity database_cross_reference “RHEA:48964”
iodide peroxidase activity database_cross_reference “RHEA:48956”
iodide peroxidase activity narrowMatch 48964
iodide peroxidase activity definition “Catalysis of the reactions: (1) 2 iodide + H2O2 + 2 H+ = diiodine + 2 H2O; (2) [thyroglobulin]-L-tyrosine + iodide + H2O2 + H+ = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O; (3) [thyroglobulin]-3-iodo-L-tyrosine + iodide + H2O2 + H+ = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O; (4) 2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-L-thyroxine + [thyroglobulin]-dehydroalanine + 2 H2O; (5) [thyroglobulin]-3-iodo-L-tyrosine + [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-3,3’,5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O.”
- database_cross_reference “PMID:8651700”
- database_cross_reference “EC:1.11.1.8”
iodide peroxidase activity narrowMatch 48956
iodide peroxidase activity narrowMatch 48968
iodide peroxidase activity database_cross_reference “RHEA:48968”
iodide peroxidase activity narrowMatch 23336
iodide peroxidase activity term tracker item “https://github.com/geneontology/go-ontology/issues/30597”^^anyURI
iodide peroxidase activity narrowMatch 48960

iodide transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015111`

Removed

iodide transmembrane transporter activity database_cross_reference “Reactome:R-HSA-5627802”
- label “SLC26A4 transports I- from cytosol to extracellular region”

Added

iodide transmembrane transporter activity database_cross_reference “Reactome:R-HSA-5627802”
- label “SLC26A4 exports I- to follicular lumen”

iodotyrosine deiodinase activity `http://purl.obolibrary.org/obo/GO_0140616`

Added

iodotyrosine deiodinase activity database_cross_reference “Reactome:R-HSA-209921”
- label “Monoiodinated tyrosine can be deiodinated”
iodotyrosine deiodinase activity database_cross_reference “Reactome:R-HSA-209960”
- label “Diiodinated tyrosine can be deiodinated”

iron acquisition from host `http://purl.obolibrary.org/obo/GO_0044847`

Added

iron acquisition from host database_cross_reference “Reactome:R-HSA-9638482”
- label “Metal ion assimilation from the host”

iron chelate transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015603`

Added

iron chelate transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9931048”
- label “FecBCDE imports Fe3+-citrates to cytosol”

iron import into the mitochondrion `http://purl.obolibrary.org/obo/GO_0048250`

Added

iron import into the mitochondrion SubClassOf intercellular transport

iron-cytochrome-c reductase activity `http://purl.obolibrary.org/obo/GO_0047726`

Removed

iron-cytochrome-c reductase activity definition “Catalysis of the reaction: ferrocytochrome c + Fe3+ = ferricytochrome c + Fe2+.”
- database_cross_reference “EC:1.9.98.1”
- database_cross_reference “MetaCyc:IRON–CYTOCHROME-C-REDUCTASE-RXN”
iron-cytochrome-c reductase activity has_related_synonym “iron-cytochrome c reductase activity”
- database_cross_reference “EC:1.9.98.1”
iron-cytochrome-c reductase activity exactMatch 1.9.98.1
iron-cytochrome-c reductase activity has_related_synonym “ferrocytochrome-c:Fe3+ oxidoreductase activity”
- database_cross_reference “EC:1.9.98.1”
iron-cytochrome-c reductase activity database_cross_reference “EC:1.9.98.1”
iron-cytochrome-c reductase activity SubClassOf oxidoreductase activity, acting on a heme group of donors

Added

iron-cytochrome-c reductase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31488”^^anyURI
iron-cytochrome-c reductase activity has_related_synonym “iron-cytochrome c reductase activity”
- database_cross_reference “EC:1.16.2.1”
iron-cytochrome-c reductase activity database_cross_reference “EC:1.16.2.1”
iron-cytochrome-c reductase activity has_related_synonym “ferrocytochrome-c:Fe3+ oxidoreductase activity”
- database_cross_reference “EC:1.16.2.1”
iron-cytochrome-c reductase activity definition “Catalysis of the reaction: Fe3+ + Fe(II)-[cytochrome c] = Fe2+ + Fe(III)-[cytochrome c].”
- database_cross_reference “RHEA:15617”
- database_cross_reference “EC:1.16.2.1”
iron-cytochrome-c reductase activity exactMatch 1.16.2.1
iron-cytochrome-c reductase activity SubClassOf oxidoreductase activity, acting on metal ions

iron-sulfur cluster export from the mitochondrion `http://purl.obolibrary.org/obo/GO_0140466`

Added

iron-sulfur cluster export from the mitochondrion SubClassOf intercellular transport

iron-sulfur transferase activity `http://purl.obolibrary.org/obo/GO_0036455`

Added

iron-sulfur transferase activity database_cross_reference “Reactome:R-HSA-8878815”
- label “Formation of 4Fe-4S cluster on ISCA1:ISCA2”

isoflavone 2’-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0033773`

Added

isoflavone 2’-hydroxylase activity narrowMatch 56108
isoflavone 2’-hydroxylase activity narrowMatch 53208
isoflavone 2’-hydroxylase activity database_cross_reference “RHEA:56108”
isoflavone 2’-hydroxylase activity database_cross_reference “RHEA:53208”

isoflavone 7-O-glucosyltransferase activity `http://purl.obolibrary.org/obo/GO_0050004`

Added

isoflavone 7-O-glucosyltransferase activity narrowMatch 17497
isoflavone 7-O-glucosyltransferase activity database_cross_reference “RHEA:56048”
isoflavone 7-O-glucosyltransferase activity narrowMatch 56048
isoflavone 7-O-glucosyltransferase activity database_cross_reference “RHEA:56056”
isoflavone 7-O-glucosyltransferase activity database_cross_reference “RHEA:55416”
isoflavone 7-O-glucosyltransferase activity database_cross_reference “RHEA:17497”
isoflavone 7-O-glucosyltransferase activity narrowMatch 55416
isoflavone 7-O-glucosyltransferase activity narrowMatch 56056

isomerase activity `http://purl.obolibrary.org/obo/GO_0016853`

Removed

isomerase activity database_cross_reference “Reactome:R-HSA-6787623”
- label “TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal”

Added

isomerase activity database_cross_reference “Reactome:R-HSA-6787623”
- label “GFUS dimer epimerises GDP-DHDMan to GDP-KDGal”

isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway `http://purl.obolibrary.org/obo/GO_0019288`

Removed

isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway definition “The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “MetaCyc:NONMEVIPP-PWY”
- database_cross_reference “PMID:18948055”

Added

isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway definition “The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate.”
- database_cross_reference “GOC:curators”
- database_cross_reference “MetaCyc:NONMEVIPP-PWY”
- database_cross_reference “PMID:18948055”

isopentenyl diphosphate biosynthetic process, mevalonate pathway `http://purl.obolibrary.org/obo/GO_0019287`

Removed

isopentenyl diphosphate biosynthetic process, mevalonate pathway definition “The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “MetaCyc:PWY-922”

Added

isopentenyl diphosphate biosynthetic process, mevalonate pathway definition “The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates.”
- database_cross_reference “GOC:curators”
- database_cross_reference “MetaCyc:PWY-922”

isopentenyl pyrophosphate transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0170045`

Removed

isopentenyl pyrophosphate transmembrane transporter activity SubClassOf obsolete phospholipid transporter activity

jasmonoyl-L-amino acid ligase activity `http://purl.obolibrary.org/obo/GO_0080123`

Added

jasmonoyl-L-amino acid ligase activity database_cross_reference “RHEA:54812”
jasmonoyl-L-amino acid ligase activity narrowMatch 54812

juvenile hormone biosynthetic process `http://purl.obolibrary.org/obo/GO_0006718`

Removed

juvenile hormone biosynthetic process definition “The chemical reactions and pathways resulting in the formation of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198547684”

Added

juvenile hormone biosynthetic process definition “The chemical reactions and pathways resulting in the formation of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198547684”

juvenile hormone catabolic process `http://purl.obolibrary.org/obo/GO_0006719`

Removed

juvenile hormone catabolic process definition “The chemical reactions and pathways resulting in the breakdown of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198547684”

Added

juvenile hormone catabolic process definition “The chemical reactions and pathways resulting in the breakdown of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198547684”

juvenile hormone metabolic process `http://purl.obolibrary.org/obo/GO_0006716`

Removed

juvenile hormone metabolic process definition “The chemical reactions and pathways involving juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198547684”

Added

juvenile hormone metabolic process definition “The chemical reactions and pathways involving juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198547684”

juvenile hormone secretion `http://purl.obolibrary.org/obo/GO_0045443`

Removed

juvenile hormone secretion definition “The regulated release of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198547684”

Added

juvenile hormone secretion definition “The regulated release of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198547684”

keratan sulfotransferase activity `http://purl.obolibrary.org/obo/GO_0045130`

Removed

keratan sulfotransferase activity database_cross_reference “Reactome:R-HSA-2046175”
- label “Further sulfation on galactose residues produces KSPG”

Added

keratan sulfotransferase activity database_cross_reference “Reactome:R-HSA-2046175”
- label “CHST1 transfers sulfate to Gal on keratan chain”

keratinocyte development `http://purl.obolibrary.org/obo/GO_0003334`

Removed

keratinocyte development database_cross_reference “Reactome:R-HSA-9725554”
- label “Differentiation of keratinocytes in interfollicular epidermis in mammalian skin”

Added

keratinocyte development database_cross_reference “Reactome:R-HSA-9725554”
- label “Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin”

ketone biosynthetic process `http://purl.obolibrary.org/obo/GO_0042181`

Removed

ketone biosynthetic process definition “The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.”
- database_cross_reference “GOC:go_curators”

Added

ketone biosynthetic process definition “The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.”
- database_cross_reference “GOC:curators”

ketone body metabolic process `http://purl.obolibrary.org/obo/GO_1902224`

Added

ketone body metabolic process database_cross_reference “Reactome:R-HSA-74182”
- label “Ketone body metabolism”

ketone catabolic process `http://purl.obolibrary.org/obo/GO_0042182`

Removed

ketone catabolic process definition “The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.”
- database_cross_reference “GOC:go_curators”

Added

ketone catabolic process definition “The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.”
- database_cross_reference “GOC:curators”

kinase inhibitor activity `http://purl.obolibrary.org/obo/GO_0019210`

Added

kinase inhibitor activity database_cross_reference “Reactome:R-HSA-170824”
- label “glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex”

kynureninase activity `http://purl.obolibrary.org/obo/GO_0030429`

Removed

kynureninase activity database_cross_reference “Reactome:R-HSA-71217”
- label “3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine”

Added

kynureninase activity database_cross_reference “Reactome:R-HSA-71217”
- label “3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine + H+”

lactase activity `http://purl.obolibrary.org/obo/GO_0000016`

Added

lactase activity database_cross_reference “RHEA:28659”
lactase activity narrowMatch 28659

lactate biosynthetic process `http://purl.obolibrary.org/obo/GO_0019249`

Removed

lactate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of lactate, the anion of lactic acid.”
- database_cross_reference “GOC:go_curators”

Added

lactate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of lactate, the anion of lactic acid.”
- database_cross_reference “GOC:curators”

lactoperoxidase activity `http://purl.obolibrary.org/obo/GO_0140825`

Added

lactoperoxidase activity has_related_synonym “heme peroxidase activity”

lactose biosynthetic process `http://purl.obolibrary.org/obo/GO_0005989`

Removed

lactose biosynthetic process definition “The chemical reactions and pathways resulting in the formation of lactose, the disaccharide galactopyranosyl-glucose.”
- database_cross_reference “GOC:go_curators”

Added

lactose biosynthetic process definition “The chemical reactions and pathways resulting in the formation of lactose, the disaccharide galactopyranosyl-glucose.”
- database_cross_reference “GOC:curators”

lactose catabolic process `http://purl.obolibrary.org/obo/GO_0005990`

Removed

lactose catabolic process definition “The chemical reactions and pathways resulting in the breakdown of lactose, the disaccharide galactopyranosyl-glucose.”
- database_cross_reference “GOC:go_curators”

Added

lactose catabolic process definition “The chemical reactions and pathways resulting in the breakdown of lactose, the disaccharide galactopyranosyl-glucose.”
- database_cross_reference “GOC:curators”
lactose catabolic process database_cross_reference “MetaCyc:BGALACT-PWY”
lactose catabolic process narrowMatch BGALACT-PWY
lactose catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI

lactose catabolic process via UDP-galactose `http://purl.obolibrary.org/obo/GO_0019515`

Removed

lactose catabolic process via UDP-galactose definition “The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate UDP-galactose.”
- database_cross_reference “GOC:go_curators”

Added

lactose catabolic process via UDP-galactose definition “The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate UDP-galactose.”
- database_cross_reference “GOC:curators”

lactose catabolic process via tagatose-6-phosphate `http://purl.obolibrary.org/obo/GO_0019512`

Removed

lactose catabolic process via tagatose-6-phosphate definition “The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate tagatose-6-phosphate.”
- database_cross_reference “GOC:go_curators”

Added

lactose catabolic process via tagatose-6-phosphate definition “The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate tagatose-6-phosphate.”
- database_cross_reference “GOC:curators”

lactose metabolic process `http://purl.obolibrary.org/obo/GO_0005988`

Removed

lactose metabolic process definition “The chemical reactions and pathways involving lactose, the disaccharide galactopyranosyl-glucose.”
- database_cross_reference “GOC:go_curators”

Added

lactose metabolic process definition “The chemical reactions and pathways involving lactose, the disaccharide galactopyranosyl-glucose.”
- database_cross_reference “GOC:curators”

laminin network `http://purl.obolibrary.org/obo/GO_0140349`

Added

laminin network term tracker item “https://github.com/geneontology/go-ontology/issues/31490”^^anyURI
laminin network SubClassOf part of some non-collagenous component of basement membrane

laminin trimer `http://purl.obolibrary.org/obo/GO_0043256`

Removed

laminin trimer SubClassOf part of some non-collagenous component of basement membrane
laminin trimer SubClassOf protein-containing complex

Added

laminin trimer term tracker item “https://github.com/geneontology/go-ontology/issues/31490”^^anyURI
laminin trimer SubClassOf extracellular protein-containing complex

laminin-1 binding `http://purl.obolibrary.org/obo/GO_0043237`

Removed

laminin-1 binding definition “Binding to laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1.”
- database_cross_reference “GOC:go_curators”

Added

laminin-1 binding definition “Binding to laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1.”
- database_cross_reference “GOC:curators”

larval serum protein complex `http://purl.obolibrary.org/obo/GO_0005616`

Removed

larval serum protein complex SubClassOf protein-containing complex
larval serum protein complex SubClassOf part of some obsolete extracellular space

Added

larval serum protein complex SubClassOf extracellular protein-containing complex

larval walking behavior `http://purl.obolibrary.org/obo/GO_0008346`

Removed

larval walking behavior definition “The behavior of a larval organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:pr”

Added

larval walking behavior definition “The behavior of a larval organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:pr”

late endosome to lysosome transport `http://purl.obolibrary.org/obo/GO_1902774`

Added

late endosome to lysosome transport SubClassOf intercellular transport

late endosome to vacuole transport `http://purl.obolibrary.org/obo/GO_0045324`

Added

late endosome to vacuole transport SubClassOf intercellular transport

lateral mesoderm development `http://purl.obolibrary.org/obo/GO_0048368`

Removed

lateral mesoderm development definition “The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure.”
- database_cross_reference “GOC:go_curators”

Added

lateral mesoderm development definition “The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure.”
- database_cross_reference “GOC:curators”

lateral mesoderm morphogenesis `http://purl.obolibrary.org/obo/GO_0048369`

Removed

lateral mesoderm morphogenesis definition “The process in which the anatomical structures of the lateral mesoderm are generated and organized.”
- database_cross_reference “GOC:go_curators”

Added

lateral mesoderm morphogenesis definition “The process in which the anatomical structures of the lateral mesoderm are generated and organized.”
- database_cross_reference “GOC:curators”

lead ion binding `http://purl.obolibrary.org/obo/GO_0032791`

Added

lead ion binding database_cross_reference “Reactome:R-HSA-190141”
- label “ALAD binds to Pb2+”

leaf development `http://purl.obolibrary.org/obo/GO_0048366`

Removed

leaf development definition “The process whose specific outcome is the progression of the leaf over time, from its formation to the mature structure.”
- database_cross_reference “GOC:go_curators”

Added

leaf development definition “The process whose specific outcome is the progression of the leaf over time, from its formation to the mature structure.”
- database_cross_reference “GOC:curators”

leaf morphogenesis `http://purl.obolibrary.org/obo/GO_0009965`

Removed

leaf morphogenesis definition “The process in which the anatomical structures of the leaf are generated and organized.”
- database_cross_reference “GOC:go_curators”

Added

leaf morphogenesis definition “The process in which the anatomical structures of the leaf are generated and organized.”
- database_cross_reference “GOC:curators”

leukocyte cell-cell adhesion `http://purl.obolibrary.org/obo/GO_0007159`

Removed

leukocyte cell-cell adhesion definition “The attachment of a leukocyte to another cell via adhesion molecules.”
- database_cross_reference “GOC:go_curators”

Added

leukocyte cell-cell adhesion definition “The attachment of a leukocyte to another cell via adhesion molecules.”
- database_cross_reference “GOC:curators”

leukotriene biosynthetic process `http://purl.obolibrary.org/obo/GO_0019370`

Removed

leukotriene biosynthetic process definition “The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.”
- database_cross_reference “GOC:go_curators”

Added

leukotriene biosynthetic process definition “The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.”
- database_cross_reference “GOC:curators”

leukotriene-C4 synthase activity `http://purl.obolibrary.org/obo/GO_0004464`

Added

leukotriene-C4 synthase activity database_cross_reference “Reactome:R-HSA-2162019”
- label “LTA4 is converted to EXA4 by ALOX15”

ligand-gated calcium channel activity `http://purl.obolibrary.org/obo/GO_0099604`

Added

ligand-gated calcium channel activity database_cross_reference “Reactome:R-HSA-169683”
- label “IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol”
ligand-gated calcium channel activity database_cross_reference “Reactome:R-HSA-169680”
- label “IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel”
ligand-gated calcium channel activity database_cross_reference “Reactome:R-HSA-4420052”
- label “Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT”
ligand-gated calcium channel activity database_cross_reference “Reactome:R-HSA-1168376”
- label “STIM1 oligomerizes”

light absorption `http://purl.obolibrary.org/obo/GO_0016037`

Removed

light absorption definition “The reception of a photon by a cell.”
- database_cross_reference “GOC:go_curators”

Added

light absorption definition “The reception of a photon by a cell.”
- database_cross_reference “GOC:curators”

lipase activator activity `http://purl.obolibrary.org/obo/GO_0060229`

Added

lipase activator activity database_cross_reference “Reactome:R-HSA-163549”
- label “phosphorylated HSL dimer + FABP4 -> phosphorylated HSL dimer:FABP4 complex”

lipid biosynthetic process `http://purl.obolibrary.org/obo/GO_0008610`

Removed

lipid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.”
- database_cross_reference “GOC:go_curators”

Added

lipid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.”
- database_cross_reference “GOC:curators”

lipid carrier activity `http://purl.obolibrary.org/obo/GO_0005319`

Removed

lipid carrier activity has_related_synonym “apolipoprotein”
lipid carrier activity definition “Enables the directed movement of lipids into, out of or within a cell, or between cells.”
- database_cross_reference “GOC:ai”
lipid carrier activity label “lipid transporter activity”
lipid carrier activity SubClassOf part of some lipid transport
lipid carrier activity SubClassOf transporter activity

Added

lipid carrier activity definition “Directly binding to a specific lipid and delivering it either to an acceptor molecule or to a specific location.”
- database_cross_reference “GOC:curators”
lipid carrier activity term tracker item “https://github.com/geneontology/go-ontology/issues/31454”^^anyURI
lipid carrier activity has_narrow_synonym “apolipoprotein”
lipid carrier activity has_broad_synonym “lipid transporter activity”
lipid carrier activity database_cross_reference “Reactome:R-HSA-5334794”
- label “FABPs bind LCFAs”
lipid carrier activity database_cross_reference “Reactome:R-HSA-8873834”
- label “STARD10 transports PC from ER membrane to lamellar body membrane”
lipid carrier activity label “lipid carrier activity”
lipid carrier activity SubClassOf molecular carrier activity

lipid catabolic process `http://purl.obolibrary.org/obo/GO_0016042`

Removed

lipid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.”
- database_cross_reference “GOC:go_curators”

Added

lipid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.”
- database_cross_reference “GOC:curators”

lipid chaperone activity `http://purl.obolibrary.org/obo/GO_7770043`

Added

lipid chaperone activity term tracker item “https://github.com/geneontology/go-ontology/issues/31403”^^anyURI
lipid chaperone activity id “GO:7770043”
lipid chaperone activity creation date “2026-01-30T01:54:24Z”
lipid chaperone activity has_obo_namespace “molecular_function”
lipid chaperone activity created by “dragon-ai-agent”
lipid chaperone activity definition “Binding to a lipid and delivering it to an acceptor protein, including enzymes, nuclear receptors, and other lipid-binding proteins. The lipid may be presented while bound to the chaperone for enzymatic modification or signaling, or fully transferred to the acceptor protein.”
- database_cross_reference “PMID:25847235”
- database_cross_reference “PMID:26658141”
- database_cross_reference “PMID:16216074”
- database_cross_reference “PMID:18511927”
lipid chaperone activity label “lipid chaperone activity”
Class: lipid chaperone activity
lipid chaperone activity SubClassOf has part some lipid binding
lipid chaperone activity SubClassOf lipid carrier activity

lipid digestion `http://purl.obolibrary.org/obo/GO_0044241`

Removed

lipid digestion definition “The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism.”
- database_cross_reference “GOC:go_curators”

Added

lipid digestion definition “The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism.”
- database_cross_reference “GOC:curators”

lipid transfer activity `http://purl.obolibrary.org/obo/GO_0120013`

Removed

lipid transfer activity has_exact_synonym “lipid carrier activity”

Added

lipid transfer activity database_cross_reference “Reactome:R-HSA-8858270”
- label “HILPDA binds lipid droplets”
lipid transfer activity database_cross_reference “Reactome:R-HSA-8856630”
- label “CIDEA:CIDEC binds lipid droplets”
lipid transfer activity database_cross_reference “Reactome:R-HSA-8874705”
- label “TTPA transports alpha-TOH from lysosomal membrane to plasma membrane”
lipid transfer activity has_broad_synonym “lipid carrier activity”
lipid transfer activity term tracker item “https://github.com/geneontology/go-ontology/issues/31454”^^anyURI
lipid transfer activity database_cross_reference “Reactome:R-HSA-8862380”
- label “HSD17B13 binds lipid droplets”
lipid transfer activity SubClassOf transporter activity

lipid transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0170055`

Removed

lipid transmembrane transporter activity SubClassOf lipid carrier activity

lipid-A 4’-kinase activity `http://purl.obolibrary.org/obo/GO_0009029`

Added

lipid-A 4’-kinase activity database_cross_reference “RHEA:20700”
lipid-A 4’-kinase activity narrowMatch 20700

lipid-A-disaccharide synthase activity `http://purl.obolibrary.org/obo/GO_0008915`

Added

lipid-A-disaccharide synthase activity narrowMatch 22668
lipid-A-disaccharide synthase activity database_cross_reference “RHEA:22668”

lipoamide binding `http://purl.obolibrary.org/obo/GO_0043544`

Removed

lipoamide binding definition “Binding to lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group.”
- database_cross_reference “GOC:go_curators”

Added

lipoamide binding definition “Binding to lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group.”
- database_cross_reference “GOC:curators”

lipoate-protein ligase activity `http://purl.obolibrary.org/obo/GO_0016979`

Removed

lipoate-protein ligase activity SubClassOf nucleotidyltransferase activity
lipoate-protein ligase activity SubClassOf ligase activity, forming carbon-nitrogen bonds

Added

lipoate-protein ligase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31616”^^anyURI
lipoate-protein ligase activity SubClassOf acid-ammonia (or amide) ligase activity

locomotor rhythm `http://purl.obolibrary.org/obo/GO_0045475`

Removed

locomotor rhythm definition “The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.”
- database_cross_reference “GOC:go_curators”

Added

locomotor rhythm definition “The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.”
- database_cross_reference “GOC:curators”

long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0016509`

Added

long-chain fatty acid [acyl-carrier-protein] ligase activity `http://purl.obolibrary.org/obo/GO_0008922`

Added

long-chain fatty acid import into peroxisome `http://purl.obolibrary.org/obo/GO_0015910`

Added

long-chain fatty acid import into peroxisome SubClassOf intercellular transport

long-chain fatty acid omega-1 hydroxylase activity `http://purl.obolibrary.org/obo/GO_0120319`

Added

long-chain fatty acid omega-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0102033`

Added

long-chain fatty acid transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0005324`

Removed

long-chain fatty acid transmembrane transporter activity database_cross_reference “Reactome:R-HSA-434381”
- label “CD36 (FAT) translocates palmitate from the extracellular region to the cytosol”

Added

long-chain fatty acid transmembrane transporter activity database_cross_reference “Reactome:R-HSA-434381”
- label “CD36 (FAT) translocates a long chain fatty acid from the extracellular region to the cytosol”
long-chain fatty acid transmembrane transporter activity narrowMatch 45256
long-chain fatty acid transmembrane transporter activity database_cross_reference “RHEA:33655”
long-chain fatty acid transmembrane transporter activity database_cross_reference “RHEA:71395”
long-chain fatty acid transmembrane transporter activity database_cross_reference “RHEA:45252”
long-chain fatty acid transmembrane transporter activity database_cross_reference “RHEA:45256”
long-chain fatty acid transmembrane transporter activity narrowMatch 45252
long-chain fatty acid transmembrane transporter activity database_cross_reference “RHEA:39807”
long-chain fatty acid transmembrane transporter activity narrowMatch 71395
long-chain fatty acid transmembrane transporter activity database_cross_reference “Reactome:R-HSA-2026996”
- label “FABP1 transports fatty acids into the nucleus”
long-chain fatty acid transmembrane transporter activity database_cross_reference “RHEA:45264”
long-chain fatty acid transmembrane transporter activity narrowMatch 39807
long-chain fatty acid transmembrane transporter activity narrowMatch 45264
long-chain fatty acid transmembrane transporter activity narrowMatch 33655

long-chain fatty acid-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0004467`

Removed

long-chain fatty acid-CoA ligase activity relatedMatch PWY-5143
long-chain fatty acid-CoA ligase activity comment “While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). Note that this term has a MetaCyc pathway reference as the pathway only has a single step.”

Added

long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:44936”
long-chain fatty acid-CoA ligase activity comment “While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).”
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:52012”
long-chain fatty acid-CoA ligase activity narrowMatch 44084
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:83199”
long-chain fatty acid-CoA ligase activity narrowMatch 67848
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:33635”
long-chain fatty acid-CoA ligase activity narrowMatch 44076
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:46208”
long-chain fatty acid-CoA ligase activity narrowMatch 52112
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:67848”
long-chain fatty acid-CoA ligase activity narrowMatch 36139
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:33607”
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:52112”
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:83019”
long-chain fatty acid-CoA ligase activity narrowMatch 44936
long-chain fatty acid-CoA ligase activity narrowMatch 44932
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:52088”
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:44208”
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:52108”
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:83035”
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:44084”
long-chain fatty acid-CoA ligase activity narrowMatch 44200
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:44220”
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:44200”
long-chain fatty acid-CoA ligase activity narrowMatch 33643
long-chain fatty acid-CoA ligase activity narrowMatch 44220
long-chain fatty acid-CoA ligase activity narrowMatch 52108
long-chain fatty acid-CoA ligase activity narrowMatch 83019
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:52016”
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:44076”
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:33643”
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:33651”
long-chain fatty acid-CoA ligase activity narrowMatch 44212
long-chain fatty acid-CoA ligase activity narrowMatch 33619
long-chain fatty acid-CoA ligase activity narrowMatch 44204
long-chain fatty acid-CoA ligase activity narrowMatch 33651
long-chain fatty acid-CoA ligase activity narrowMatch 33607
long-chain fatty acid-CoA ligase activity narrowMatch 44192
long-chain fatty acid-CoA ligase activity narrowMatch 52012
long-chain fatty acid-CoA ligase activity narrowMatch 52008
long-chain fatty acid-CoA ligase activity narrowMatch 83203
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:44216”
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:33619”
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:33615”
long-chain fatty acid-CoA ligase activity narrowMatch 33635
long-chain fatty acid-CoA ligase activity narrowMatch 44216
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:44932”
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:44224”
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:44092”
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:85307”
long-chain fatty acid-CoA ligase activity narrowMatch 30751
long-chain fatty acid-CoA ligase activity narrowMatch 52088
long-chain fatty acid-CoA ligase activity narrowMatch 83035
long-chain fatty acid-CoA ligase activity narrowMatch 44224
long-chain fatty acid-CoA ligase activity narrowMatch 44092
long-chain fatty acid-CoA ligase activity narrowMatch 46208
long-chain fatty acid-CoA ligase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI
long-chain fatty acid-CoA ligase activity narrowMatch 83347
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:44192”
long-chain fatty acid-CoA ligase activity narrowMatch 85307
long-chain fatty acid-CoA ligase activity narrowMatch 52016
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:52008”
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:83203”
long-chain fatty acid-CoA ligase activity narrowMatch 83199
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:36139”
long-chain fatty acid-CoA ligase activity narrowMatch 52116
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:44212”
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:30751”
long-chain fatty acid-CoA ligase activity narrowMatch 44208
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:44204”
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:83347”
long-chain fatty acid-CoA ligase activity narrowMatch 33647
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:33647”
long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:52116”
long-chain fatty acid-CoA ligase activity narrowMatch 33615

long-chain fatty acyl-CoA dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0004466`

Added

long-chain fatty acyl-CoA hydrolase activity `http://purl.obolibrary.org/obo/GO_0052816`

Added

long-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:40119”
long-chain fatty acyl-CoA hydrolase activity narrowMatch 40135
long-chain fatty acyl-CoA hydrolase activity narrowMatch 40119
long-chain fatty acyl-CoA hydrolase activity narrowMatch 55044
long-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:40139”
long-chain fatty acyl-CoA hydrolase activity narrowMatch 67696
long-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:83071”
long-chain fatty acyl-CoA hydrolase activity narrowMatch 67700
long-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:59948”
long-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:67712”
long-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:40151”
long-chain fatty acyl-CoA hydrolase activity narrowMatch 40783
long-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:67696”
long-chain fatty acyl-CoA hydrolase activity narrowMatch 40723
long-chain fatty acyl-CoA hydrolase activity narrowMatch 83355
long-chain fatty acyl-CoA hydrolase activity narrowMatch 54976
long-chain fatty acyl-CoA hydrolase activity narrowMatch 59948
long-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:40131”
long-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:40135”
long-chain fatty acyl-CoA hydrolase activity narrowMatch 40139
long-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:54976”
long-chain fatty acyl-CoA hydrolase activity narrowMatch 30139
long-chain fatty acyl-CoA hydrolase activity narrowMatch 40143
long-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:40415”
long-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:83355”
long-chain fatty acyl-CoA hydrolase activity narrowMatch 40131
long-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:40143”
long-chain fatty acyl-CoA hydrolase activity narrowMatch 59940
long-chain fatty acyl-CoA hydrolase activity narrowMatch 40415
long-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:40723”
long-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:55044”
long-chain fatty acyl-CoA hydrolase activity narrowMatch 40419
long-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:67700”
long-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:40783”
long-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:30139”
long-chain fatty acyl-CoA hydrolase activity narrowMatch 40147
long-chain fatty acyl-CoA hydrolase activity narrowMatch 67712
long-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:40419”
long-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:59940”
long-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:65240”
long-chain fatty acyl-CoA hydrolase activity narrowMatch 65240
long-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:40147”
long-chain fatty acyl-CoA hydrolase activity narrowMatch 16645
long-chain fatty acyl-CoA hydrolase activity narrowMatch 83071
long-chain fatty acyl-CoA hydrolase activity narrowMatch 40151
long-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:16645”

long-chain fatty acyl-CoA oxidase activity `http://purl.obolibrary.org/obo/GO_0120524`

Added

long-chain fatty acyl-CoA oxidase activity narrowMatch 40167
long-chain fatty acyl-CoA oxidase activity narrowMatch 38971
long-chain fatty acyl-CoA oxidase activity database_cross_reference “RHEA:69643”
long-chain fatty acyl-CoA oxidase activity database_cross_reference “RHEA:78571”
long-chain fatty acyl-CoA oxidase activity narrowMatch 83059
long-chain fatty acyl-CoA oxidase activity database_cross_reference “RHEA:38971”
long-chain fatty acyl-CoA oxidase activity database_cross_reference “RHEA:40167”
long-chain fatty acyl-CoA oxidase activity database_cross_reference “RHEA:83059”
long-chain fatty acyl-CoA oxidase activity narrowMatch 69643
long-chain fatty acyl-CoA oxidase activity narrowMatch 40183
long-chain fatty acyl-CoA oxidase activity narrowMatch 78571
long-chain fatty acyl-CoA oxidase activity narrowMatch 78587
long-chain fatty acyl-CoA oxidase activity database_cross_reference “RHEA:78587”
long-chain fatty acyl-CoA oxidase activity database_cross_reference “RHEA:40183”

long-chain fatty aldehyde dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0050061`

Added

long-chain fatty aldehyde oxidative decarbonylase activity `http://purl.obolibrary.org/obo/GO_0160238`

Added

long-chain-alcohol O-fatty-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0047196`

Added

long-chain-alcohol oxidase activity `http://purl.obolibrary.org/obo/GO_0046577`

Added

long-chain-alcohol oxidase activity narrowMatch 76475
long-chain-alcohol oxidase activity database_cross_reference “RHEA:76479”
long-chain-alcohol oxidase activity narrowMatch 69488
long-chain-alcohol oxidase activity database_cross_reference “RHEA:69488”
long-chain-alcohol oxidase activity narrowMatch 76479
long-chain-alcohol oxidase activity database_cross_reference “RHEA:69484”
long-chain-alcohol oxidase activity database_cross_reference “RHEA:76475”
long-chain-alcohol oxidase activity narrowMatch 69484

long-chain-fatty-acyl-CoA reductase activity `http://purl.obolibrary.org/obo/GO_0050062`

Added

low-density lipoprotein particle receptor binding `http://purl.obolibrary.org/obo/GO_0050750`

Added

low-density lipoprotein particle receptor binding database_cross_reference “Reactome:R-HSA-2423785”
- label “CR:atREs binds apoE and HSPG”

lumenal side of Golgi membrane `http://purl.obolibrary.org/obo/GO_0098547`

Removed

lumenal side of Golgi membrane definition “The side of the Golgi membrane that faces the lumen.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:ab”

Added

lumenal side of Golgi membrane definition “The leaflet of the Golgi membrane that faces the lumen, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:ab”
lumenal side of Golgi membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI

lumenal side of cis-Golgi cisternae membrane `http://purl.obolibrary.org/obo/GO_0160277`

Removed

lumenal side of cis-Golgi cisternae membrane definition “The membrane leaflet of the cis-Golgi cisternae membrane that faces the Golgi lumen and is involved in glycosylation and lumen-facing cargo recognition.”
- database_cross_reference “PMID:34597626”
- database_cross_reference “PMID:23913272”

Added

lumenal side of cis-Golgi cisternae membrane definition “The leaflet of the cis-Golgi cisternae membrane that faces the Golgi lumen, including any protein embedded in, attached to, or peripherally associated with it. This is the site where glycosylation and lumen-facing cargo recognition occur.”
- database_cross_reference “PMID:34597626”
- database_cross_reference “PMID:23913272”
lumenal side of cis-Golgi cisternae membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI

lumenal side of cis-Golgi network membrane `http://purl.obolibrary.org/obo/GO_0140178`

Removed

lumenal side of cis-Golgi network membrane definition “The membrane leaflet of the cis-Golgi network directly contacts the Golgi lumen and may be involved in glycosylation, cargo sorting, or interactions with resident Golgi proteins.”
- database_cross_reference “PMID:34080016”
- database_cross_reference “PMID:29802621”
- database_cross_reference “PMID:1747103”

Added

lumenal side of cis-Golgi network membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
lumenal side of cis-Golgi network membrane definition “The leaflet of the cis-Golgi network membrane directly contacts the Golgi lumen, including any protein embedded in, attached to, or peripherally associated with it. This is the site where glycosylation, cargo sorting, or interactions with resident Golgi proteins occur.”
- database_cross_reference “PMID:34080016”
- database_cross_reference “PMID:29802621”
- database_cross_reference “PMID:1747103”

lumenal side of early endosome membrane `http://purl.obolibrary.org/obo/GO_0098550`

Removed

lumenal side of early endosome membrane definition “The side (leaflet) of the early endosome membrane that faces the lumen.”
- database_cross_reference “GOC:lr”

Added

lumenal side of early endosome membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
lumenal side of early endosome membrane definition “The leaflet of the early endosome membrane that faces the lumen, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:lr”

lumenal side of endoplasmic reticulum membrane `http://purl.obolibrary.org/obo/GO_0098553`

Removed

lumenal side of endoplasmic reticulum membrane definition “The side (leaflet) of the plasma membrane that faces the lumen.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:ab”

Added

lumenal side of endoplasmic reticulum membrane definition “The leaflet of the endoplasmic reticulum membrane that faces the lumen, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:ab”
lumenal side of endoplasmic reticulum membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI

lumenal side of endosome membrane `http://purl.obolibrary.org/obo/GO_0098565`

Removed

lumenal side of endosome membrane definition “The side (leaflet) of the endosome membrane that faces the lumen.”
- database_cross_reference “GOC:dos”

Added

lumenal side of endosome membrane definition “The leaflet of the endosome membrane that faces the lumen, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:dos”
lumenal side of endosome membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI

lumenal side of late endosome membrane `http://purl.obolibrary.org/obo/GO_0098551`

Removed

lumenal side of late endosome membrane definition “The side (leaflet) of the late endosome membrane that faces the lumen.”
- database_cross_reference “GOC:lr”

Added

lumenal side of late endosome membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
lumenal side of late endosome membrane definition “The leaflet of the late endosomal membrane that faces the lumen, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:lr”

lumenal side of lysosomal membrane `http://purl.obolibrary.org/obo/GO_0098575`

Removed

lumenal side of lysosomal membrane definition “The side (leaflet) of the lysosomal membrane that faces the lumen.”
- database_cross_reference “GOC:dos”

Added

lumenal side of lysosomal membrane definition “The leaflet of the lysosomal membrane that faces the lumen, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:dos”
lumenal side of lysosomal membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI

lumenal side of medial-Golgi cisterna membrane `http://purl.obolibrary.org/obo/GO_0160280`

Removed

lumenal side of medial-Golgi cisterna membrane definition “The membrane leaflet of the medial-Golgi cisternae that directly contacts the Golgi lumen, hosts glycosyltransferases and enzymes to modify N-linked oligosaccharides by trimming mannose and adding N-acetylglucosamine.”
- database_cross_reference “PMID:28777890”
- database_cross_reference “PMID:36658747”
- database_cross_reference “PMID:34597626”
- database_cross_reference “PMID:39331042”

Added

lumenal side of medial-Golgi cisterna membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
lumenal side of medial-Golgi cisterna membrane definition “The leaflet of the medial-Golgi cisternae membrane that faces the Golgi lumen, including any protein embedded in, attached to, or peripherally associated with it. This is the site where protein glycosylation occur.”
- database_cross_reference “PMID:28777890”
- database_cross_reference “PMID:36658747”
- database_cross_reference “PMID:34597626”
- database_cross_reference “PMID:39331042”

lumenal side of membrane `http://purl.obolibrary.org/obo/GO_0098576`

Removed

lumenal side of membrane definition “Any side (leaflet) of a membrane that faces the lumen of an organelle.”
- database_cross_reference “GOC:dos”

Added

lumenal side of membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
lumenal side of membrane definition “The leaflet of an organelle membrane that faces the lumen, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:dos”

lumenal side of plastid thylakoid membrane `http://purl.obolibrary.org/obo/GO_0098571`

Removed

lumenal side of plastid thylakoid membrane definition “The side (leaflet) of the plastid thylakoid membrane that faces the lumen, and any proteins embedded in it or loosely bound to its surface.”
- database_cross_reference “GOC:dos”

Added

lumenal side of plastid thylakoid membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
lumenal side of plastid thylakoid membrane definition “The leaflet of a plastid thylakoid membrane that faces the lumen, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:dos”

lumenal side of rough endoplasmic reticulum membrane `http://purl.obolibrary.org/obo/GO_0098555`

Removed

lumenal side of rough endoplasmic reticulum membrane definition “The side (leaflet) of the rough endoplasmic reticulum membrane that faces the lumen.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:ab”

Added

lumenal side of rough endoplasmic reticulum membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
lumenal side of rough endoplasmic reticulum membrane definition “The leaflet of the rough endoplasmic reticulum membrane that faces the lumen, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:ab”

lumenal side of smooth endoplasmic reticulum membrane `http://purl.obolibrary.org/obo/GO_0098558`

Removed

lumenal side of smooth endoplasmic reticulum membrane definition “The side (leaflet) of the smooth endoplasmic reticulum membrane that faces the lumen.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:ab”

Added

lumenal side of smooth endoplasmic reticulum membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
lumenal side of smooth endoplasmic reticulum membrane definition “The leaflet of the smooth endoplasmic reticulum membrane that faces the lumen, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:ab”

lumenal side of trans-Golgi cisternae membrane `http://purl.obolibrary.org/obo/GO_0160289`

Removed

lumenal side of trans-Golgi cisternae membrane definition “The membrane leaflet of the trans-Golgi cisternae membrane that faces the Golgi lumen. It is involved in the final steps of glycan processing, proteolytic modification, and cargo maturation prior to sorting at the trans-Golgi network.”
- database_cross_reference “PMID:38307322”
- database_cross_reference “PMID:34597626”
- database_cross_reference “PMID:6121819”

Added

lumenal side of trans-Golgi cisternae membrane definition “The leaflet of the trans-Golgi cisternae membrane that faces the Golgi lumen, including any protein embedded in, attached to, or peripherally associated with it. This is the site where the final steps of glycan processing, proteolytic modification, and cargo maturation prior to sorting at the trans-Golgi network occur.”
- database_cross_reference “PMID:38307322”
- database_cross_reference “PMID:34597626”
- database_cross_reference “PMID:6121819”
lumenal side of trans-Golgi cisternae membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI

lumenal side of trans-Golgi network membrane `http://purl.obolibrary.org/obo/GO_0160282`

Removed

lumenal side of trans-Golgi network membrane definition “The membrane leaflet of the trans-Golgi network membrane that faces the Golgi lumen.”
- database_cross_reference “PMID:38307322”
- database_cross_reference “PMID:34597626”
- database_cross_reference “PMID:23913272”

Added

lumenal side of trans-Golgi network membrane definition “The leaflet of the trans-Golgi network membrane that faces the Golgi lumen, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “PMID:38307322”
- database_cross_reference “PMID:34597626”
- database_cross_reference “PMID:23913272”
lumenal side of trans-Golgi network membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI

lumenal side of trans-Golgi network transport vesicle membrane `http://purl.obolibrary.org/obo/GO_0098540`

Removed

lumenal side of trans-Golgi network transport vesicle membrane definition “The side (leaflet) of the trans-Golgi network transport vesicle membrane that faces the lumen.”
- database_cross_reference “GOC:ab”

Added

lumenal side of trans-Golgi network transport vesicle membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
lumenal side of trans-Golgi network transport vesicle membrane definition “The leaflet of a trans-Golgi network transport vesicle membrane that faces the lumen, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:ab”

lumenal side of transport vesicle membrane `http://purl.obolibrary.org/obo/GO_0098538`

Removed

lumenal side of transport vesicle membrane definition “The side (leaflet) of the transport vesicle membrane that faces the lumen.”
- database_cross_reference “GOC:ab”

Added

lumenal side of transport vesicle membrane definition “The leaflet of a transport vesicle membrane that faces the lumen, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:ab”
lumenal side of transport vesicle membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI

lymphocyte differentiation `http://purl.obolibrary.org/obo/GO_0030098`

Removed

lymphocyte differentiation definition “The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “CL:0000542”

Added

lymphocyte differentiation definition “The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.”
- database_cross_reference “GOC:curators”
- database_cross_reference “CL:0000542”

lysophosphatidic acid phosphatase activity `http://purl.obolibrary.org/obo/GO_0052642`

Added

lysophosphatidic acid phosphatase activity database_cross_reference “RHEA:39835”
lysophosphatidic acid phosphatase activity database_cross_reference “RHEA:53592”
lysophosphatidic acid phosphatase activity narrowMatch 53600
lysophosphatidic acid phosphatase activity narrowMatch 53592
lysophosphatidic acid phosphatase activity narrowMatch 53596
lysophosphatidic acid phosphatase activity database_cross_reference “RHEA:53600”
lysophosphatidic acid phosphatase activity narrowMatch 39835
lysophosphatidic acid phosphatase activity database_cross_reference “RHEA:53596”
lysophosphatidic acid phosphatase activity database_cross_reference “RHEA:53604”
lysophosphatidic acid phosphatase activity narrowMatch 53604

lysophospholipase C activity `http://purl.obolibrary.org/obo/GO_0140324`

Added

lysophospholipase C activity narrowMatch 86375
lysophospholipase C activity database_cross_reference “RHEA:86379”
lysophospholipase C activity narrowMatch 86379
lysophospholipase C activity database_cross_reference “RHEA:86375”

lysophospholipid:sodium symporter activity `http://purl.obolibrary.org/obo/GO_0051978`

Removed

lysophospholipid:sodium symporter activity SubClassOf obsolete phospholipid transporter activity

lysosomal glycocalyx `http://purl.obolibrary.org/obo/GO_0090123`

Removed

lysosomal glycocalyx EquivalentTo glycocalyx and (part of some lysosome)
lysosomal glycocalyx SubClassOf glycocalyx

Added

lysosomal glycocalyx term tracker item “https://github.com/geneontology/go-ontology/issues/31720”^^anyURI
lysosomal glycocalyx SubClassOf cellular anatomical structure

lysosomal lumen acidification `http://purl.obolibrary.org/obo/GO_0007042`

Removed

lysosomal lumen acidification definition “Any process that reduces the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion.”
- database_cross_reference “GOC:jid”
lysosomal lumen acidification SubClassOf obsolete regulation of lysosomal lumen pH

Added

lysosomal lumen acidification definition “Any process that reduces the pH of the lysosomal lumen, corresponding to an increase in hydrogen ion concentration.”
- database_cross_reference “GOC:jid”

lysosomal lumen pH elevation `http://purl.obolibrary.org/obo/GO_0035752`

Removed

lysosomal lumen pH elevation definition “Any process that increases the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion.”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:rph”
lysosomal lumen pH elevation SubClassOf obsolete regulation of lysosomal lumen pH

Added

lysosomal lumen pH elevation definition “Any process that increases the pH of the lysosomal lumen, corresponding to a decrease in hydrogen ion concentration.”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:rph”

lysosome to ER cholesterol transport `http://purl.obolibrary.org/obo/GO_0090120`

Added

lysosome to ER cholesterol transport SubClassOf intercellular transport

m-xylene catabolic process `http://purl.obolibrary.org/obo/GO_0042185`

Removed

m-xylene catabolic process definition “The chemical reactions and pathways resulting in the breakdown of m-xylene, 1,3-dimethylbenzene, a colorless, liquid aromatic hydrocarbon.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:go_curators”

Added

m-xylene catabolic process definition “The chemical reactions and pathways resulting in the breakdown of m-xylene, 1,3-dimethylbenzene, a colorless, liquid aromatic hydrocarbon.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:curators”

mRNA (adenine-N1-)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0061953`

Added

mRNA (adenine-N1-)-methyltransferase activity database_cross_reference “Reactome:R-HSA-9937529”
- label “TRMT61B methylates adenosine-616 and adenosine-617 of MT-CYB mRNA”
mRNA (adenine-N1-)-methyltransferase activity database_cross_reference “Reactome:R-HSA-9937512”
- label “TRMT61B methylates adenosine-371 of MT-ND1 mRNA”
mRNA (adenine-N1-)-methyltransferase activity database_cross_reference “Reactome:R-HSA-9937521”
- label “TRMT61B methylates adenosine-185 of MT-CO2 mRNA”
mRNA (adenine-N1-)-methyltransferase activity database_cross_reference “Reactome:R-HSA-9937508”
- label “TRMT61B methylates adenosine-1472 of MT-CO1 mRNA”
mRNA (adenine-N1-)-methyltransferase activity database_cross_reference “Reactome:R-HSA-9937535”
- label “TRMT61B methylates adenosine-252 of MT-ND4L mRNA”
mRNA (adenine-N1-)-methyltransferase activity database_cross_reference “Reactome:R-HSA-9937518”
- label “TRMT61B methylates adenosine-333, adenosine-458, and adenosine-707 of MT-CO3 mRNA”

mRNA 5’-cap (guanine-N7-)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0004482`

Added

mRNA 5’-cap (guanine-N7-)-methyltransferase activity database_cross_reference “Reactome:R-HSA-9923104”
- label “NS5 acts as a cap N7 methyltransferase to methylate 5 G pppA of DENV genomic +ssRNA”

mRNA 5’-triphosphate monophosphatase activity `http://purl.obolibrary.org/obo/GO_0140818`

Added

mRNA cytidine N-acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0106162`

Removed

mRNA cytidine N-acetyltransferase activity label “mRNA N-acetyltransferase activity”

Added

mRNA cytidine N-acetyltransferase activity has_broad_synonym “mRNA N-acetyltransferase activity”
mRNA cytidine N-acetyltransferase activity terms_contributor “https://github.com/geneontology/go-ontology/issues/16755”^^anyURI
mRNA cytidine N-acetyltransferase activity label “mRNA cytidine N-acetyltransferase activity”
mRNA cytidine N-acetyltransferase activity SubClassOf catalytic activity, acting on a nucleic acid

mRNA guanylyltransferase activity `http://purl.obolibrary.org/obo/GO_0004484`

Added

mRNA guanylyltransferase activity database_cross_reference “RHEA:60844”
mRNA guanylyltransferase activity database_cross_reference “RHEA:60836”
mRNA guanylyltransferase activity database_cross_reference “Reactome:R-HSA-9923071”
- label “NS5 transfers guanylyl onto DENV genomic 5’-ppRNA”
mRNA guanylyltransferase activity narrowMatch 60844
mRNA guanylyltransferase activity narrowMatch 60836

mRNA modification `http://purl.obolibrary.org/obo/GO_0016556`

Added

mRNA modification database_cross_reference “Reactome:R-HSA-9937008”
- label “Mitochondrial mRNA modification”

macromolecule methylation `http://purl.obolibrary.org/obo/GO_0043414`

Removed

macromolecule methylation definition “The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule.”
- database_cross_reference “GOC:go_curators”

Added

macromolecule methylation definition “The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule.”
- database_cross_reference “GOC:curators”

macromolecule modification `http://purl.obolibrary.org/obo/GO_0043412`

Removed

macromolecule modification definition “The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties.”
- database_cross_reference “GOC:go_curators”

Added

macromolecule modification definition “The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties.”
- database_cross_reference “GOC:curators”

magnesium ion export from mitochondrion `http://purl.obolibrary.org/obo/GO_1990616`

Added

magnesium ion export from mitochondrion SubClassOf intercellular transport

malate-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0050074`

Removed

malate-CoA ligase activity SubClassOf acid-thiol ligase activity

Added

malate-CoA ligase activity SubClassOf CoA-ligase activity

male-specific antibacterial humoral response `http://purl.obolibrary.org/obo/GO_0006962`

Removed

male-specific antibacterial humoral response definition “An immune response against bacteria, specific to males and mediated through a body fluid.”
- database_cross_reference “GOC:go_curators”

Added

male-specific antibacterial humoral response definition “An immune response against bacteria, specific to males and mediated through a body fluid.”
- database_cross_reference “GOC:curators”

mandelate catabolic process `http://purl.obolibrary.org/obo/GO_0019596`

Removed

mandelate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic.”
- database_cross_reference “GOC:go_curators”

Added

mandelate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic.”
- database_cross_reference “GOC:curators”

manganese peroxidase activity `http://purl.obolibrary.org/obo/GO_0016689`

Removed

manganese peroxidase activity definition “Catalysis of the reaction: 2 Mn2+ + 2 H+ + hydrogen peroxide = 2 Mn3+ + 2 H2O.”
- database_cross_reference “EC:1.11.1.13”

Added

manganese peroxidase activity definition “Catalysis of the reaction: 2 Mn2+ + 2 H+ + H2O2 = 2 Mn3+ + 2 H2O.”
- database_cross_reference “EC:1.11.1.13”

mannitol catabolic process `http://purl.obolibrary.org/obo/GO_0019592`

Added

mannitol catabolic process narrowMatch MANNIDEG-PWY
mannitol catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI
mannitol catabolic process database_cross_reference “MetaCyc:MANNIDEG-PWY”

mannitol-1-phosphate 5-dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0008926`

Removed

mannitol-1-phosphate 5-dehydrogenase activity relatedMatch MANNIDEG-PWY
mannitol-1-phosphate 5-dehydrogenase activity comment “Note that this term has a MetaCyc pathway reference as the pathway only has a single step.”

Added

mannitol-1-phosphate 5-dehydrogenase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI

mannokinase activity `http://purl.obolibrary.org/obo/GO_0019158`

Added

mannokinase activity database_cross_reference “Reactome:R-HSA-8931653”
- label “POMK 6-phosphorylates mannose in GalNAc-GlcNAc-Man-DAG1”

matrilin complex `http://purl.obolibrary.org/obo/GO_0120216`

Removed

matrilin complex definition “A cartilage extracellular matrix complex that mediates interactions between major components of the extracellular matrix such as collagens and proteoglycans and contributes to their fibrillar network. Exists as an obligate homotrimer.”
- database_cross_reference “PMID:10367731”
- database_cross_reference “PMID:15075323”
- database_cross_reference “PMID:9699631”
- database_cross_reference “PMID:15094109”
matrilin complex SubClassOf protein-containing complex

Added

matrilin complex definition “A cartilage extracellular matrix complex that mediates interactions between major components of the extracellular matrix such as collagens and proteoglycans and contributes to their fibrillar network. Exists as an obligate homotrimer.”
- database_cross_reference “PMID:10367731”
- database_cross_reference “PMID:29310791”
- database_cross_reference “PMID:15075323”
- database_cross_reference “PMID:9699631”
matrilin complex SubClassOf extracellular protein-containing complex

matrix side of mitochondrial inner membrane `http://purl.obolibrary.org/obo/GO_0099617`

Removed

matrix side of mitochondrial inner membrane definition “The side (leaflet) of the mitochondrial inner membrane that faces the matrix.”
- database_cross_reference “GOC:dos”

Added

matrix side of mitochondrial inner membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
matrix side of mitochondrial inner membrane definition “The leaflet of a mitochondrial inner membrane that faces the matrix, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:dos”

mechanosensory behavior `http://purl.obolibrary.org/obo/GO_0007638`

Removed

mechanosensory behavior definition “Behavior that is dependent upon the sensation of a mechanical stimulus.”
- database_cross_reference “GOC:go_curators”

Added

mechanosensory behavior definition “Behavior that is dependent upon the sensation of a mechanical stimulus.”
- database_cross_reference “GOC:curators”

medium-chain fatty acid omega-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0140981`

Added

medium-chain fatty acid-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0031956`

Added

medium-chain fatty acid-CoA ligase activity narrowMatch 54952
medium-chain fatty acid-CoA ligase activity narrowMatch 33631
medium-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:44088”
medium-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:33631”
medium-chain fatty acid-CoA ligase activity narrowMatch 44080
medium-chain fatty acid-CoA ligase activity narrowMatch 33623
medium-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:44228”
medium-chain fatty acid-CoA ligase activity narrowMatch 44228
medium-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:33623”
medium-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:44080”
medium-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:54952”
medium-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:43740”
medium-chain fatty acid-CoA ligase activity narrowMatch 44088
medium-chain fatty acid-CoA ligase activity narrowMatch 43740

medium-chain fatty acyl-CoA dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0070991`

Added

medium-chain fatty acyl-CoA hydrolase activity `http://purl.obolibrary.org/obo/GO_0052815`

Added

medium-chain fatty acyl-CoA hydrolase activity narrowMatch 65216
medium-chain fatty acyl-CoA hydrolase activity narrowMatch 40059
medium-chain fatty acyl-CoA hydrolase activity narrowMatch 30135
medium-chain fatty acyl-CoA hydrolase activity narrowMatch 59952
medium-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:55048”
medium-chain fatty acyl-CoA hydrolase activity narrowMatch 65232
medium-chain fatty acyl-CoA hydrolase activity narrowMatch 40115
medium-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:59952”
medium-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:40115”
medium-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:65172”
medium-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:40059”
medium-chain fatty acyl-CoA hydrolase activity narrowMatch 65212
medium-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:65212”
medium-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:30143”
medium-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:65216”
medium-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:30135”
medium-chain fatty acyl-CoA hydrolase activity narrowMatch 55048
medium-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:65232”
medium-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:40223”
medium-chain fatty acyl-CoA hydrolase activity narrowMatch 40223
medium-chain fatty acyl-CoA hydrolase activity narrowMatch 30143
medium-chain fatty acyl-CoA hydrolase activity narrowMatch 65172

medium-chain fatty acyl-CoA oxidase activity `http://purl.obolibrary.org/obo/GO_0120523`

Added

medium-chain fatty acyl-CoA oxidase activity narrowMatch 40311
medium-chain fatty acyl-CoA oxidase activity database_cross_reference “RHEA:40179”
medium-chain fatty acyl-CoA oxidase activity narrowMatch 40171
medium-chain fatty acyl-CoA oxidase activity narrowMatch 66204
medium-chain fatty acyl-CoA oxidase activity database_cross_reference “RHEA:40171”
medium-chain fatty acyl-CoA oxidase activity database_cross_reference “RHEA:38987”
medium-chain fatty acyl-CoA oxidase activity database_cross_reference “RHEA:40311”
medium-chain fatty acyl-CoA oxidase activity narrowMatch 40179
medium-chain fatty acyl-CoA oxidase activity narrowMatch 40175
medium-chain fatty acyl-CoA oxidase activity database_cross_reference “RHEA:66204”
medium-chain fatty acyl-CoA oxidase activity narrowMatch 38987
medium-chain fatty acyl-CoA oxidase activity database_cross_reference “RHEA:40175”

medium-chain fatty aldehyde dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0052814`

Added

meiotic spindle organization `http://purl.obolibrary.org/obo/GO_0000212`

Removed

meiotic spindle organization definition “A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:go_curators”

Added

meiotic spindle organization definition “A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:curators”

melanin biosynthetic process from tyrosine `http://purl.obolibrary.org/obo/GO_0006583`

Removed

melanin biosynthetic process from tyrosine definition “The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine.”
- database_cross_reference “GOC:go_curators”

Added

melanin biosynthetic process from tyrosine definition “The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine.”
- database_cross_reference “GOC:curators”

melanin metabolic process `http://purl.obolibrary.org/obo/GO_0006582`

Removed

melanin metabolic process definition “The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.”
- database_cross_reference “GOC:go_curators”

Added

melanin metabolic process definition “The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.”
- database_cross_reference “GOC:curators”

melanosomal lumen acidification `http://purl.obolibrary.org/obo/GO_7770038`

Added

melanosomal lumen acidification definition “Any process that reduces the pH of the melanosomal lumen, corresponding to an increase in hydrogen ion concentration.”
- database_cross_reference “PMID:23205854”
- database_cross_reference “PMID:35469906”
melanosomal lumen acidification has_exact_synonym “melanosome pH reduction”
melanosomal lumen acidification term tracker item “https://github.com/geneontology/go-ontology/issues/28838”^^anyURI
melanosomal lumen acidification label “melanosomal lumen acidification”
melanosomal lumen acidification id “GO:7770038”
melanosomal lumen acidification has_obo_namespace “biological_process”
melanosomal lumen acidification created by “dragon-ai-agent”
Class: melanosomal lumen acidification
melanosomal lumen acidification SubClassOf intracellular pH reduction

melanosomal lumen pH elevation `http://purl.obolibrary.org/obo/GO_7770039`

Added

melanosomal lumen pH elevation definition “Any process that increases the pH of the melanosomal lumen, corresponding to a decrease in hydrogen ion concentration.”
- database_cross_reference “PMID:35469906”
- database_cross_reference “PMID:27140606”
- database_cross_reference “PMID:11310796”
- database_cross_reference “PMID:32966160”
melanosomal lumen pH elevation created by “dragon-ai-agent”
melanosomal lumen pH elevation term tracker item “https://github.com/geneontology/go-ontology/issues/28838”^^anyURI
melanosomal lumen pH elevation has_obo_namespace “biological_process”
melanosomal lumen pH elevation has_exact_synonym “melanosome pH elevation”
melanosomal lumen pH elevation label “melanosomal lumen pH elevation”
melanosomal lumen pH elevation id “GO:7770039”
Class: melanosomal lumen pH elevation
melanosomal lumen pH elevation SubClassOf intracellular pH elevation

membrane insertase activity `http://purl.obolibrary.org/obo/GO_0032977`

Added

membrane insertase activity database_cross_reference “Reactome:R-HSA-9926981”
- label “Bam complex inserts Hbp into outer membrane”

membrane invagination `http://purl.obolibrary.org/obo/GO_0010324`

Removed

membrane invagination in_subset goslim_yeast

membrane protein dislocase activity `http://purl.obolibrary.org/obo/GO_0140567`

Removed

membrane protein dislocase activity has_related_synonym “transmembrane helix dislocase transmembrane protein dislocase activity”
membrane protein dislocase activity SubClassOf protein transporter activity

Added

membrane protein dislocase activity has_related_synonym “transmembrane protein dislocase activity”
membrane protein dislocase activity has_related_synonym “transmembrane helix dislocase”
membrane protein dislocase activity term tracker item “https://github.com/geneontology/go-ontology/issues/30369”^^anyURI
membrane protein dislocase activity SubClassOf protein carrier activity

membrane-bounded organelle `http://purl.obolibrary.org/obo/GO_0043227`

Removed

membrane-bounded organelle definition “Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.”
- database_cross_reference “GOC:go_curators”

Added

membrane-bounded organelle definition “Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.”
- database_cross_reference “GOC:curators”

membrane-membrane adaptor activity `http://purl.obolibrary.org/obo/GO_0140177`

Removed

membrane-membrane adaptor activity definition “The binding activity of a molecule that brings together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle.”
- database_cross_reference “GOC:curator”

Added

membrane-membrane adaptor activity definition “The binding activity of a molecule that brings together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle.”
- database_cross_reference “GOC:curators”

membraneless organelle `http://purl.obolibrary.org/obo/GO_0043228`

Removed

membraneless organelle definition “Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.”
- database_cross_reference “GOC:go_curators”

Added

membraneless organelle definition “Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.”
- database_cross_reference “GOC:curators”

mercury ion binding `http://purl.obolibrary.org/obo/GO_0045340`

Removed

mercury ion binding definition “Binding to a mercury ion (Hg2+).”
- database_cross_reference “GOC:go_curators”

Added

mercury ion binding definition “Binding to a mercury ion (Hg2+).”
- database_cross_reference “GOC:curators”

mesoderm formation `http://purl.obolibrary.org/obo/GO_0001707`

Removed

mesoderm formation definition “The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.”
- database_cross_reference “GOC:go_curators”

Added

mesoderm formation definition “The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.”
- database_cross_reference “GOC:curators”

mesoderm morphogenesis `http://purl.obolibrary.org/obo/GO_0048332`

Removed

mesoderm morphogenesis definition “The process in which the anatomical structures of the mesoderm are generated and organized.”
- database_cross_reference “GOC:go_curators”

Added

mesoderm morphogenesis definition “The process in which the anatomical structures of the mesoderm are generated and organized.”
- database_cross_reference “GOC:curators”

mesodermal cell fate commitment `http://purl.obolibrary.org/obo/GO_0001710`

Removed

mesodermal cell fate commitment definition “The cell differentiation process that results in commitment of a cell to become part of the mesoderm.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0878932437”

Added

mesodermal cell fate commitment definition “The cell differentiation process that results in commitment of a cell to become part of the mesoderm.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0878932437”

mesodermal cell fate determination `http://purl.obolibrary.org/obo/GO_0007500`

Removed

mesodermal cell fate determination definition “The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0878932437”

Added

mesodermal cell fate determination definition “The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0878932437”

mesodermal cell fate specification `http://purl.obolibrary.org/obo/GO_0007501`

Removed

mesodermal cell fate specification definition “The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.”
- database_cross_reference “GOC:go_curators”

Added

mesodermal cell fate specification definition “The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.”
- database_cross_reference “GOC:curators”

metabolic process `http://purl.obolibrary.org/obo/GO_0008152`

Removed

metabolic process definition “A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198547684”

Added

metabolic process definition “A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198547684”

metal ion transport `http://purl.obolibrary.org/obo/GO_0030001`

Added

metal ion transport database_cross_reference “Reactome:R-HSA-425410”
- label “Metal ion SLC transporters”

metallocarboxypeptidase activity `http://purl.obolibrary.org/obo/GO_0004181`

Removed

metallocarboxypeptidase activity database_cross_reference “Reactome:R-HSA-2022378”
- label “ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)”
metallocarboxypeptidase activity database_cross_reference “Reactome:R-HSA-2022379”
- label “ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7)”
metallocarboxypeptidase activity database_cross_reference “Reactome:R-HSA-2028294”
- label “Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9)”

Added

metallocarboxypeptidase activity database_cross_reference “Reactome:R-HSA-2022379”
- label “ACE2(18-805):Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(25-31) (Angiotensin-(1-7))”
metallocarboxypeptidase activity database_cross_reference “Reactome:R-HSA-9944488”
- label “ACE2:Zn2+ cleaves 1-Ala-AGT(25-32) to yield Alamandine (1-Ala-AGT(25-31)”
metallocarboxypeptidase activity database_cross_reference “Reactome:R-HSA-2022378”
- label “ACE2(18-805):Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9))”
metallocarboxypeptidase activity database_cross_reference “Reactome:R-HSA-2028294”
- label “Mast Cell Carboxypeptidase hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9))”

metallodipeptidase activity `http://purl.obolibrary.org/obo/GO_0070573`

Removed

metallodipeptidase activity database_cross_reference “Reactome:R-HSA-2022398”
- label “ACE:Zn2+ hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)”
metallodipeptidase activity database_cross_reference “Reactome:R-HSA-2022405”
- label “ACE:Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)”
metallodipeptidase activity database_cross_reference “Reactome:R-HSA-2065355”
- label “Secreted ACE:Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)”

Added

metallodipeptidase activity database_cross_reference “Reactome:R-HSA-2022398”
- label “ACE:Zn2+ hydrolyzes AGT(25-33) (Angiotensin-(1-9)) to AGT(25-31) (Angiotensin-(1-7))”
metallodipeptidase activity database_cross_reference “Reactome:R-HSA-2065355”
- label “Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))”
metallodipeptidase activity database_cross_reference “Reactome:R-HSA-2022405”
- label “ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))”

metalloendopeptidase activity `http://purl.obolibrary.org/obo/GO_0004222`

Added

metalloendopeptidase activity database_cross_reference “Reactome:R-HSA-9010034”
- label “ADAM10:Zn2+:TSPANs cleaves APP(18-770)”

metalloendopeptidase activity involved in amyloid precursor protein catabolic process `http://purl.obolibrary.org/obo/GO_1902945`

Removed

metalloendopeptidase activity involved in amyloid precursor protein catabolic process database_cross_reference “Reactome:R-HSA-9010034”
- label “ADAM10:Zn2+:TSPANs cleaves APP(18-770)”

metallopeptidase activity `http://purl.obolibrary.org/obo/GO_0008237`

Removed

metallopeptidase activity database_cross_reference “Reactome:R-HSA-2022368”
- label “MME:Zn2+ (Neprilysin) hydrolyses AGT(34-42)”
metallopeptidase activity database_cross_reference “Reactome:R-HSA-2022393”
- label “ANPEP:Zn2+ hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8)”
metallopeptidase activity database_cross_reference “Reactome:R-HSA-2022396”
- label “MME:Zn2+ (Neprilysin) hydrolyses AGT(34-43)”
metallopeptidase activity database_cross_reference “Reactome:R-HSA-2022399”
- label “ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8)”

Added

metallopeptidase activity database_cross_reference “Reactome:R-HSA-2022368”
- label “MME:Zn2+ (Neprilysin) hydrolyses AGT(25-33) (Angiotensin-(1-9)) to AGT(25-31) (Angiotensin-(1-7)”
metallopeptidase activity database_cross_reference “Reactome:R-HSA-2022399”
- label “ENPEP:Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(26-32) (Angiotensin-(2-8))”
metallopeptidase activity database_cross_reference “Reactome:R-HSA-2022396”
- label “MME:Zn2+ (Neprilysin) hydrolyses AGT(25-34) (Angiotensin-(1-10)) to AGT(25-31) (Angiotensin-(1-7))”
metallopeptidase activity database_cross_reference “Reactome:R-HSA-2022393”
- label “ANPEP:Zn2+ hydrolyzes AGT(26-32) (Angiotensin-(2-8)) to AGT(27-32) (Angiotensin-(3-8))”

methanethiol oxidase activity `http://purl.obolibrary.org/obo/GO_0018549`

Removed

methanethiol oxidase activity definition “Catalysis of the reaction: methanethiol + O2 + H2O = formaldehyde + hydrogen sulfide + hydrogen peroxide.”
- database_cross_reference “EC:1.8.3.4”

Added

methanethiol oxidase activity definition “Catalysis of the reaction: methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H+.”
- database_cross_reference “RHEA:11812”

methanol metabolic process `http://purl.obolibrary.org/obo/GO_0015945`

Removed

methanol metabolic process definition “The chemical reactions and pathways involving methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

methanol metabolic process definition “The chemical reactions and pathways involving methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

methionine gamma-lyase activity `http://purl.obolibrary.org/obo/GO_0018826`

Removed

methionine gamma-lyase activity definition “Catalysis of the reaction: L-methionine = methanethiol + NH3 + 2-oxobutanoate.”
- database_cross_reference “EC:4.4.1.11”
- database_cross_reference “RHEA:23800”

Added

methionine gamma-lyase activity definition “Catalysis of the reaction: L-methionine + H2O = methanethiol + 2-oxobutanoate + NH4+.”
- database_cross_reference “RHEA:23800”

methionyl-tRNA formyltransferase activity `http://purl.obolibrary.org/obo/GO_0004479`

Removed

methionyl-tRNA formyltransferase activity has_related_synonym “N-terminal peptidyl-methionine N-formylation”
- database_cross_reference “GO:curators”
methionyl-tRNA formyltransferase activity has_related_synonym “conversion of mitochondrial met-tRNAf to fmet-tRNA”
- database_cross_reference “GO:curators”
methionyl-tRNA formyltransferase activity has_related_synonym “conversion of met-tRNAf to fmet-tRNA”
- database_cross_reference “GO:curators”
methionyl-tRNA formyltransferase activity has_related_synonym “mitochondrial N-terminal peptidyl-methionine N-formylation”
- database_cross_reference “GO:curators”

Added

methionyl-tRNA formyltransferase activity has_related_synonym “N-terminal peptidyl-methionine N-formylation”
- database_cross_reference “GOC:curators”
methionyl-tRNA formyltransferase activity has_related_synonym “conversion of met-tRNAf to fmet-tRNA”
- database_cross_reference “GOC:curators”
methionyl-tRNA formyltransferase activity has_related_synonym “conversion of mitochondrial met-tRNAf to fmet-tRNA”
- database_cross_reference “GOC:curators”
methionyl-tRNA formyltransferase activity has_related_synonym “mitochondrial N-terminal peptidyl-methionine N-formylation”
- database_cross_reference “GOC:curators”

methylation `http://purl.obolibrary.org/obo/GO_0032259`

Added

methylation term tracker item “https://github.com/geneontology/go-ontology/issues/27423”^^anyURI
methylation in_subset gocheck_obsoletion_candidate

methylcrotonoyl-CoA carboxylase activity `http://purl.obolibrary.org/obo/GO_0004485`

Removed

methylcrotonoyl-CoA carboxylase activity database_cross_reference “Reactome:R-HSA-70773”
- label “beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA]”
methylcrotonoyl-CoA carboxylase activity database_cross_reference “Reactome:R-HSA-508308”
- label “beta-methylglutaconyl-CoA + ADP + orthophosphate <=> beta-methylcrotonyl-CoA + ATP + CO2 (MCCA)”

Added

methylcrotonoyl-CoA carboxylase activity database_cross_reference “Reactome:R-HSA-508308”
- label “beta-methylglutaconyl-CoA + ADP + orthophosphate <=> beta-methylcrotonyl-CoA + ATP + HCO3- (MCCA)”
methylcrotonoyl-CoA carboxylase activity database_cross_reference “Reactome:R-HSA-70773”
- label “beta-methylcrotonyl-CoA + ATP + HCO3- <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O (MCCA)”

methylenediurea deaminase activity `http://purl.obolibrary.org/obo/GO_0047424`

Removed

methylenediurea deaminase activity definition “Catalysis of the reaction: 2 H2O + methylenediurea = CO2 + 2 NH3 + N-hydroxymethylurea.”
- database_cross_reference “EC:3.5.3.21”
- database_cross_reference “MetaCyc:3.5.3.21-RXN”
- database_cross_reference “RHEA:15929”

Added

methylenediurea deaminase activity definition “Catalysis of the reaction: methylenediurea + 2 H2O + 2 H+ = N-(hydroxymethyl)urea + 2 NH4+ + CO2.”
- database_cross_reference “RHEA:15929”

methylenetetrahydrofolate dehydrogenase (NADP+) activity `http://purl.obolibrary.org/obo/GO_0004488`

Added

methylenetetrahydrofolate dehydrogenase (NADP+) activity database_cross_reference “Reactome:R-HSA-200644”
- label “5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+”
methylenetetrahydrofolate dehydrogenase (NADP+) activity database_cross_reference “Reactome:R-HSA-200718”
- label “MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG”

methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity `http://purl.obolibrary.org/obo/GO_0004491`

Removed

methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity database_cross_reference “Reactome:R-HSA-70893”
- label “methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+”

Added

methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity database_cross_reference “Reactome:R-HSA-70893”
- label “methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+”

methylquinoline catabolic process `http://purl.obolibrary.org/obo/GO_0019335`

Removed

methylquinoline catabolic process database_cross_reference “MetaCyc:PWY-721”
- comment “skos:narrowMatch”

Added

methylquinoline catabolic process database_cross_reference “MetaCyc:PWY-721”
methylquinoline catabolic process narrowMatch PWY-721

methylthioalkylmalate synthase activity `http://purl.obolibrary.org/obo/GO_0010177`

Added

methylthioalkylmalate synthase activity narrowMatch 25605
methylthioalkylmalate synthase activity database_cross_reference “RHEA:25605”
methylthioalkylmalate synthase activity database_cross_reference “RHEA:25601”
methylthioalkylmalate synthase activity narrowMatch 25601

methyltransferase activity `http://purl.obolibrary.org/obo/GO_0008168`

Added

methyltransferase activity database_cross_reference “Reactome:R-HSA-5333608”
- label “GSSebGalNac is reduced and methylated to MeSebGalNac”

methyltransferase cap1 activity `http://purl.obolibrary.org/obo/GO_0004483`

Added

methyltransferase cap1 activity database_cross_reference “Reactome:R-HSA-9923097”
- label “NS5 acts as a cap 2’-O-methyltransferase to methylate 5 m7GpppA of DENV genomic +ssRNA”

methyltransferase cap2 activity `http://purl.obolibrary.org/obo/GO_0120550`

Removed

methyltransferase cap2 activity database_cross_reference “MetaCyc:RXN-14928”
- database_cross_reference “skos:narrowMatch”

Added

methyltransferase cap2 activity database_cross_reference “MetaCyc:RXN-14928”
methyltransferase cap2 activity narrowMatch RXN-14928

microfibril `http://purl.obolibrary.org/obo/GO_0001527`

Removed

microfibril definition “Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins.”
- database_cross_reference “PMID:27026396”
- database_cross_reference “PMID:31226403”

Added

microfibril term tracker item “https://github.com/geneontology/go-ontology/issues/31712”^^anyURI
microfibril definition “Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain microfibrillar-Associated Proteins (MFAPs): MFAP1, MFAP2 (also known as MAGP-1), MFAP3, MFAP4, and MFAP5 (also known as MAGP-2).”
- database_cross_reference “PMID:27026396”
- database_cross_reference “PMID:31226403”

microsporidian-type endospore `http://purl.obolibrary.org/obo/GO_0090641`

Added

microsporidian-type endospore term tracker item “https://github.com/geneontology/go-ontology/issues/31720”^^anyURI

microtubule nucleation `http://purl.obolibrary.org/obo/GO_0007020`

Removed

microtubule nucleation definition “The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules (‘de novo’ microtubule formation).”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0815316194”
- database_cross_reference “PMID:12517712”

Added

microtubule nucleation definition “The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules (‘de novo’ microtubule formation).”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0815316194”
- database_cross_reference “PMID:12517712”

microtubule polymerization `http://purl.obolibrary.org/obo/GO_0046785`

Removed

microtubule polymerization definition “The addition of tubulin heterodimers to one or both ends of a microtubule.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:ai”

Added

microtubule polymerization definition “The addition of tubulin heterodimers to one or both ends of a microtubule.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:ai”

mithramycin dehydrogenase (NADPH) activity `http://purl.obolibrary.org/obo/GO_0102357`

Added

mithramycin dehydrogenase (NADPH) activity exactMatch 85451
mithramycin dehydrogenase (NADPH) activity database_cross_reference “RHEA:85451”

mitochondrial DNA replication `http://purl.obolibrary.org/obo/GO_0006264`

Added

mitochondrial DNA replication database_cross_reference “Reactome:R-HSA-9913635”
- label “Strand-asynchronous mitochondrial DNA replication”

mitochondrial translation `http://purl.obolibrary.org/obo/GO_0032543`

Removed

mitochondrial translation definition “The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.”
- database_cross_reference “GOC:go_curators”

Added

mitochondrial translation definition “The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.”
- database_cross_reference “GOC:curators”

mitochondrial translational termination `http://purl.obolibrary.org/obo/GO_0070126`

Added

mitochondrial translational termination database_cross_reference “Reactome:R-HSA-9937383”
- label “Mitochondrial ribosome-associated quality control”

mitochondrial-lysosomal membrane contact site `http://purl.obolibrary.org/obo/GO_7770051`

Added

mitochondrial-lysosomal membrane contact site label “mitochondrial-lysosomal membrane contact site”
mitochondrial-lysosomal membrane contact site created by “dragon-ai-agent”
mitochondrial-lysosomal membrane contact site has_exact_synonym “mitochondria-lysosome contact site”
mitochondrial-lysosomal membrane contact site has_exact_synonym “mitochondria-lysosome membrane contact site”
mitochondrial-lysosomal membrane contact site has_exact_synonym “lysosome-mitochondrion membrane contact site”
mitochondrial-lysosomal membrane contact site has_exact_synonym “mitochondria-lysosome MCS”
mitochondrial-lysosomal membrane contact site creation date “2026-02-11T18:32:29Z”
mitochondrial-lysosomal membrane contact site term tracker item “https://github.com/geneontology/go-ontology/issues/31553”^^anyURI
mitochondrial-lysosomal membrane contact site has_obo_namespace “cellular_component”
mitochondrial-lysosomal membrane contact site definition “An organelle membrane contact site between the mitochondrial outer membrane and the lysosomal membrane.”
- database_cross_reference “PMID:33372681”
- database_cross_reference “PMID:32703809”
- database_cross_reference “PMID:30898429”
- database_cross_reference “PMID:29364868”
- database_cross_reference “PMID:33753743”
- database_cross_reference “PMID:35249745”
mitochondrial-lysosomal membrane contact site id “GO:7770051”
Class: mitochondrial-lysosomal membrane contact site
mitochondrial-lysosomal membrane contact site SubClassOf vacuole-mitochondrion membrane contact site

mitochondrion to lysosome vesicle-mediated transport `http://purl.obolibrary.org/obo/GO_0099074`

Added

mitochondrion to lysosome vesicle-mediated transport SubClassOf intercellular transport

mitochondrion to peroxisome vesicle-mediated transport `http://purl.obolibrary.org/obo/GO_0099076`

Added

mitochondrion to peroxisome vesicle-mediated transport SubClassOf intercellular transport

mitotic cell cycle, embryonic `http://purl.obolibrary.org/obo/GO_0045448`

Removed

mitotic cell cycle, embryonic definition “The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo.”
- database_cross_reference “GOC:go_curators”

Added

mitotic cell cycle, embryonic definition “The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo.”
- database_cross_reference “GOC:curators”

mitotic spindle organization `http://purl.obolibrary.org/obo/GO_0007052`

Removed

mitotic spindle organization definition “A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:go_curators”

Added

mitotic spindle organization definition “A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:curators”

modification-dependent protein catabolic process `http://purl.obolibrary.org/obo/GO_0019941`

Removed

modification-dependent protein catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein.”
- database_cross_reference “GOC:go_curators”

Added

modification-dependent protein catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein.”
- database_cross_reference “GOC:curators”

molecular adaptor activity `http://purl.obolibrary.org/obo/GO_0060090`

Removed

molecular adaptor activity has_broad_synonym “protein complex scaffold activity”
molecular adaptor activity has_broad_synonym “protein-containing complex scaffold activity”

Added

molecular adaptor activity database_cross_reference “Reactome:R-HSA-2564826”
- label “4Fe-4S cluster assembles on NUBP2:NUBP1 scaffold”
molecular adaptor activity term tracker item “https://github.com/geneontology/go-ontology/issues/31509”^^anyURI

molecular carrier activity `http://purl.obolibrary.org/obo/GO_0140104`

Added

molecular carrier activity database_cross_reference “Reactome:R-HSA-2855259”
- label “atROL binds RBP1 (parenchymal cell)”
molecular carrier activity database_cross_reference “Reactome:R-HSA-2399913”
- label “atRAL binds to RBP2”
molecular carrier activity database_cross_reference “Reactome:R-HSA-2395764”
- label “atREs binds to nascent CM”
molecular carrier activity database_cross_reference “Reactome:R-HSA-209944”
- label “25(OH)D binds GC”
molecular carrier activity database_cross_reference “Reactome:R-HSA-2404142”
- label “atROL binds RBP1”
molecular carrier activity database_cross_reference “Reactome:R-HSA-5246478”
- label “APOM binds retinoids”
molecular carrier activity database_cross_reference “Reactome:R-HSA-196126”
- label “STAR mediates CHOL translocation from cytosol to mitochondrial intermembrane space”
molecular carrier activity database_cross_reference “Reactome:R-HSA-209738”
- label “VD3 binds GC”
molecular carrier activity database_cross_reference “Reactome:R-HSA-9663511”
- label “BIL binds GSTA1, FABP1”
molecular carrier activity database_cross_reference “Reactome:R-HSA-8870499”
- label “PLEKHA3,8 bind PI4P, ARF1”
molecular carrier activity database_cross_reference “Reactome:R-HSA-8932980”
- label “SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane”
molecular carrier activity database_cross_reference “Reactome:R-HSA-9661432”
- label “BIL binds ALB”
molecular carrier activity database_cross_reference “Reactome:R-HSA-8963851”
- label “VD3 dissociates from GC”

molecular function activator activity `http://purl.obolibrary.org/obo/GO_0140677`

Added

molecular function activator activity database_cross_reference “Reactome:R-HSA-8866941”
- label “MID1IP1 binds THRSP”

molecular sensor activity `http://purl.obolibrary.org/obo/GO_0140299`

Added

molecular sensor activity database_cross_reference “Reactome:R-HSA-9854368”
- label “ROS,RNS oxidize ACO2:4Fe-4S”

molecular sequestering activity `http://purl.obolibrary.org/obo/GO_0140313`

Added

molecular sequestering activity database_cross_reference “Reactome:R-HSA-2404134”
- label “RBP4:atROL binds TTR”

molybdate ion export from vacuole `http://purl.obolibrary.org/obo/GO_0090414`

Added

molybdate ion export from vacuole SubClassOf intercellular transport

molybdopterin molybdotransferase activity `http://purl.obolibrary.org/obo/GO_0061599`

Added

molybdopterin molybdotransferase activity narrowMatch 79031
molybdopterin molybdotransferase activity database_cross_reference “RHEA:78687”
molybdopterin molybdotransferase activity narrowMatch 78687
molybdopterin molybdotransferase activity database_cross_reference “RHEA:79031”
molybdopterin molybdotransferase activity narrowMatch 79035
molybdopterin molybdotransferase activity database_cross_reference “RHEA:79035”

monoacylglycerol lipase activity `http://purl.obolibrary.org/obo/GO_0047372`

Added

monoacylglycerol lipase activity narrowMatch 34019
monoacylglycerol lipase activity narrowMatch 44688
monoacylglycerol lipase activity database_cross_reference “RHEA:34019”
monoacylglycerol lipase activity database_cross_reference “RHEA:44688”

monoamine transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0008504`

Removed

monoamine transmembrane transporter activity database_cross_reference “Reactome:R-HSA-444160”
- label “VMAT1/2 can mediate the transport of biogenic amines”
monoamine transmembrane transporter activity database_cross_reference “Reactome:R-HSA-379393”
- label “SLC6A3 cotransports DA, Na+ from extracellular region to cytosol”
monoamine transmembrane transporter activity SubClassOf part of some monoamine transport

Added

monoamine transmembrane transporter activity database_cross_reference “Reactome:R-HSA-379393”
- label “SLC6A3 cotransports DA, Na+, Cl- from extracellular region to cytosol”

monoatomic cation channel activity `http://purl.obolibrary.org/obo/GO_0005261`

Removed

monoatomic cation channel activity database_cross_reference “Reactome:R-HSA-1168376”
- label “STIM1 oligomerizes”
monoatomic cation channel activity database_cross_reference “Reactome:R-HSA-4420052”
- label “Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT”
monoatomic cation channel activity database_cross_reference “Reactome:R-HSA-169683”
- label “IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol”

monoatomic ion transport `http://purl.obolibrary.org/obo/GO_0006811`

Removed

monoatomic ion transport database_cross_reference “Reactome:R-HSA-425393”
- label “Transport of inorganic cations/anions and amino acids/oligopeptides”

monocarboxylic acid transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0008028`

Removed

monocarboxylic acid transmembrane transporter activity database_cross_reference “Reactome:R-HSA-429749”
- label “SLC5A8 transports monocarboxylates from extracellular region to cytosol”

Added

monocarboxylic acid transmembrane transporter activity database_cross_reference “Reactome:R-HSA-429749”
- label “SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol”

monomethylamine methyltransferase activity `http://purl.obolibrary.org/obo/GO_0043852`

Removed

monomethylamine methyltransferase activity definition “Catalysis of the reaction: monomethylamine + a monomethylamine corrinoid protein = a methylated monomethylamine corrinoid protein + NH3.”
- database_cross_reference “PMID:9195968”

Added

monomethylamine methyltransferase activity definition “Catalysis of the reaction: Co(I)-[methylamine-specific corrinoid protein] + methylamine + H+ = methyl-Co(III)-[methylamine-specific corrinoid protein] + NH4+.”
- database_cross_reference “RHEA:26059”
- database_cross_reference “PMID:9195968”

monooxygenase activity `http://purl.obolibrary.org/obo/GO_0004497`

Removed

monooxygenase activity database_cross_reference “Reactome:R-HSA-76466”
- label “CYP4A11 12-hydroxylates DDCX”
monooxygenase activity database_cross_reference “Reactome:R-HSA-5662662”
- label “Tyrosinase oxidises tyrosine to dopaquinone”
monooxygenase activity database_cross_reference “Reactome:R-HSA-5662692”
- label “Dopa is oxidized to dopaquinone by TYR”
monooxygenase activity database_cross_reference “Reactome:R-HSA-5663050”
- label “DHI and DHICA polymerize forming eumelanin”

Added

monooxygenase activity database_cross_reference “Reactome:R-HSA-76466”
- label “CYP4A11 omega-hydroxylates DDCX”

monoterpenoid biosynthetic process `http://purl.obolibrary.org/obo/GO_0016099`

Removed

monoterpenoid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of monoterpenoid compounds, terpenoids having a C10 skeleton.”
- database_cross_reference “GOC:go_curators”

Added

monoterpenoid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of monoterpenoid compounds, terpenoids having a C10 skeleton.”
- database_cross_reference “GOC:curators”

monoterpenoid catabolic process `http://purl.obolibrary.org/obo/GO_0016100`

Removed

monoterpenoid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of monoterpenoid compounds, terpenoids having a C10 skeleton.”
- database_cross_reference “GOC:go_curators”

Added

monoterpenoid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of monoterpenoid compounds, terpenoids having a C10 skeleton.”
- database_cross_reference “GOC:curators”

morphogen activity `http://purl.obolibrary.org/obo/GO_0016015`

Removed

morphogen activity definition “Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient.”
- database_cross_reference “GOC:go_curators”

Added

morphogen activity definition “Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient.”
- database_cross_reference “GOC:curators”

multicellular organismal-level extracellular fluid acidification `http://purl.obolibrary.org/obo/GO_7770056`

Added

multicellular organismal-level extracellular fluid acidification creation date “2026-03-24T17:37:00Z”
multicellular organismal-level extracellular fluid acidification created by “dragon-ai-agent”
multicellular organismal-level extracellular fluid acidification has_obo_namespace “biological_process”
multicellular organismal-level extracellular fluid acidification definition “Any process that reduces the pH of an extracellular fluid of a multicellular organism, corresponding to an increase in hydrogen ion concentration.”
- database_cross_reference “PMID:33326313”
- database_cross_reference “PMID:35666106”
multicellular organismal-level extracellular fluid acidification label “multicellular organismal-level extracellular fluid acidification”
multicellular organismal-level extracellular fluid acidification term tracker item “https://github.com/geneontology/go-ontology/issues/29164”^^anyURI
multicellular organismal-level extracellular fluid acidification id “GO:7770056”
multicellular organismal-level extracellular fluid acidification has_exact_synonym “extracellular fluid pH reduction”
multicellular organismal-level extracellular fluid acidification has_exact_synonym “multicellular organismal-level extracellular fluid pH reduction”
Class: multicellular organismal-level extracellular fluid acidification
multicellular organismal-level extracellular fluid acidification SubClassOf multicellular organismal process
multicellular organismal-level extracellular fluid acidification SubClassOf pH reduction

multimerin complex `http://purl.obolibrary.org/obo/GO_1990972`

Added

multimerin complex SubClassOf extracellular protein-containing complex

multiplexin collagen trimer `http://purl.obolibrary.org/obo/GO_0140156`

Added

multiplexin collagen trimer SubClassOf extracellular protein-containing complex

muscle cell differentiation `http://purl.obolibrary.org/obo/GO_0042692`

Removed

muscle cell differentiation definition “The process in which a relatively unspecialized cell acquires specialized features of a muscle cell.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “CL:0000187”

Added

muscle cell differentiation definition “The process in which a relatively unspecialized cell acquires specialized features of a muscle cell.”
- database_cross_reference “GOC:curators”
- database_cross_reference “CL:0000187”

muscle cell fate commitment `http://purl.obolibrary.org/obo/GO_0042693`

Removed

muscle cell fate commitment definition “The process in which the cellular identity of muscle cells is acquired and determined.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “CL:0000187”

Added

muscle cell fate commitment definition “The process in which the cellular identity of muscle cells is acquired and determined.”
- database_cross_reference “GOC:curators”
- database_cross_reference “CL:0000187”

muscle cell fate determination `http://purl.obolibrary.org/obo/GO_0007521`

Removed

muscle cell fate determination definition “The cell fate determination process in which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “CL:0000187”

Added

muscle cell fate determination definition “The cell fate determination process in which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed.”
- database_cross_reference “GOC:curators”
- database_cross_reference “CL:0000187”

muscle cell fate specification `http://purl.obolibrary.org/obo/GO_0042694`

Removed

muscle cell fate specification definition “The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “CL:0000187”

Added

muscle cell fate specification definition “The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.”
- database_cross_reference “GOC:curators”
- database_cross_reference “CL:0000187”

myo-inositol transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0005365`

Added

myo-inositol transmembrane transporter activity database_cross_reference “Reactome:R-HSA-1855195”
- label “I(1,3,4,5,6)P5 transports from the cytosol to the ER lumen”
myo-inositol transmembrane transporter activity database_cross_reference “Reactome:R-HSA-1855186”
- label “I(1,3,4,5)P4 transports from the cytosol to the ER lumen”
myo-inositol transmembrane transporter activity database_cross_reference “Reactome:R-HSA-1855217”
- label “I(1,4,5)P3 transports from the ER lumen to the cytosol”
myo-inositol transmembrane transporter activity database_cross_reference “Reactome:R-HSA-1855164”
- label “IP6 transports from the cytosol to the ER lumen”
myo-inositol transmembrane transporter activity database_cross_reference “Reactome:R-HSA-1855155”
- label “I(1,3,4,5,6)P5 transports from the ER lumen to the cytosol”

myoblast differentiation `http://purl.obolibrary.org/obo/GO_0045445`

Removed

myoblast differentiation definition “The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “CL:0000056”
- database_cross_reference “GOC:mtg_muscle”

Added

myoblast differentiation definition “The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.”
- database_cross_reference “GOC:curators”
- database_cross_reference “CL:0000056”
- database_cross_reference “GOC:mtg_muscle”

myoblast fate determination `http://purl.obolibrary.org/obo/GO_0007518`

Removed

myoblast fate determination definition “The cell fate determination process in which a cell becomes capable of differentiating autonomously into a myoblast regardless of its environment; upon determination, the cell fate cannot be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “CL:0000056”

Added

myoblast fate determination definition “The cell fate determination process in which a cell becomes capable of differentiating autonomously into a myoblast regardless of its environment; upon determination, the cell fate cannot be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.”
- database_cross_reference “GOC:curators”
- database_cross_reference “CL:0000056”

myristoyltransferase activity `http://purl.obolibrary.org/obo/GO_0019107`

Added

myristoyltransferase activity database_cross_reference “Reactome:R-HSA-9919009”
- label “NMT1 interacts with E”

negative regluation of nuclear-transribed mRNA catabolic process, no-go decay `http://purl.obolibrary.org/obo/GO_0170075`

Added

negative regluation of nuclear-transribed mRNA catabolic process, no-go decay has_exact_synonym “negative regulation of nuclear-transcribed mRNA degradation, no-go decay”
negative regluation of nuclear-transribed mRNA catabolic process, no-go decay has_exact_synonym “negative regulation of no-go mRNA decay”
negative regluation of nuclear-transribed mRNA catabolic process, no-go decay definition “Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, no-go decay.”
- database_cross_reference “PMID:41607283”
negative regluation of nuclear-transribed mRNA catabolic process, no-go decay has_exact_synonym “negative regulation of nuclear-transcribed mRNA breakdown, no-go decay”
negative regluation of nuclear-transribed mRNA catabolic process, no-go decay label “negative regluation of nuclear-transribed mRNA catabolic process, no-go decay”
negative regluation of nuclear-transribed mRNA catabolic process, no-go decay has_obo_namespace “biological_process”
negative regluation of nuclear-transribed mRNA catabolic process, no-go decay creation date “2026-03-23T21:12:37Z”
negative regluation of nuclear-transribed mRNA catabolic process, no-go decay id “GO:0170075”
negative regluation of nuclear-transribed mRNA catabolic process, no-go decay term tracker item “https://github.com/geneontology/go-ontology/issues/31747”^^anyURI
negative regluation of nuclear-transribed mRNA catabolic process, no-go decay has_exact_synonym “negative regulation of nuclear-transcribed mRNA catabolism, no-go decay”
negative regluation of nuclear-transribed mRNA catabolic process, no-go decay has_exact_synonym “negative regulation of no-go decay”
negative regluation of nuclear-transribed mRNA catabolic process, no-go decay created by “ew”
Class: negative regluation of nuclear-transribed mRNA catabolic process, no-go decay
negative regluation of nuclear-transribed mRNA catabolic process, no-go decay EquivalentTo biological regulation and (negatively regulates some nuclear-transcribed mRNA catabolic process, no-go decay)
negative regluation of nuclear-transribed mRNA catabolic process, no-go decay SubClassOf negatively regulates some nuclear-transcribed mRNA catabolic process, no-go decay
negative regluation of nuclear-transribed mRNA catabolic process, no-go decay SubClassOf negative regulation of mRNA catabolic process

negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_1902647`

Removed

negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process SubClassOf negative regulation of phosphatidylinositol biosynthetic process

Added

negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process SubClassOf negative regulation of phospholipid biosynthetic process

negative regulation of B cell differentiation `http://purl.obolibrary.org/obo/GO_0045578`

Removed

negative regulation of B cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of B cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of B cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of B cell differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of BMP signaling pathway `http://purl.obolibrary.org/obo/GO_0030514`

Removed

negative regulation of BMP signaling pathway definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of BMP signaling pathway definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.”
- database_cross_reference “GOC:curators”

negative regulation of DNA recombination `http://purl.obolibrary.org/obo/GO_0045910`

Removed

negative regulation of DNA recombination definition “Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of DNA recombination definition “Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination.”
- database_cross_reference “GOC:curators”

negative regulation of DNA repair `http://purl.obolibrary.org/obo/GO_0045738`

Removed

negative regulation of DNA repair definition “Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of DNA repair definition “Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair.”
- database_cross_reference “GOC:curators”

negative regulation of DNA replication `http://purl.obolibrary.org/obo/GO_0008156`

Removed

negative regulation of DNA replication definition “Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of DNA replication definition “Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication.”
- database_cross_reference “GOC:curators”

negative regulation of DNA-templated transcription `http://purl.obolibrary.org/obo/GO_0045892`

Removed

negative regulation of DNA-templated transcription definition “Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:txnOH”

Added

negative regulation of DNA-templated transcription definition “Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:txnOH”

negative regulation of G protein-coupled receptor signaling pathway `http://purl.obolibrary.org/obo/GO_0045744`

Removed

negative regulation of G protein-coupled receptor signaling pathway definition “Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of G protein-coupled receptor signaling pathway definition “Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway.”
- database_cross_reference “GOC:curators”

negative regulation of GABA catabolic process `http://purl.obolibrary.org/obo/GO_1901716`

Removed

negative regulation of GABA catabolic process has_exact_synonym “negative regulation of GABA catabolic process”
- database_cross_reference “GOC:TermGenie”
negative regulation of GABA catabolic process label “negative regulation of gamma-aminobutyric acid catabolic process”

Added

negative regulation of GABA catabolic process label “negative regulation of GABA catabolic process”
negative regulation of GABA catabolic process has_exact_synonym “negative regulation of gamma-aminobutyric acid catabolic process”
- database_cross_reference “GOC:TermGenie”

negative regulation of GCN2-mediated signaling `http://purl.obolibrary.org/obo/GO_7770045`

Added

negative regulation of GCN2-mediated signaling term tracker item “https://github.com/geneontology/go-ontology/issues/31453”^^anyURI
negative regulation of GCN2-mediated signaling creation date “2026-02-04T18:20:09Z”
negative regulation of GCN2-mediated signaling id “GO:7770045”
negative regulation of GCN2-mediated signaling created by “dragon-ai-agent”
negative regulation of GCN2-mediated signaling has_obo_namespace “biological_process”
negative regulation of GCN2-mediated signaling label “negative regulation of GCN2-mediated signaling”
negative regulation of GCN2-mediated signaling definition “Any process that stops, prevents, or reduces the frequency, rate or extent of GCN2-mediated signaling.”
- database_cross_reference “PMID:23899355”
Class: negative regulation of GCN2-mediated signaling
negative regulation of GCN2-mediated signaling EquivalentTo biological regulation and (negatively regulates some GCN2-mediated signaling)
negative regulation of GCN2-mediated signaling SubClassOf negatively regulates some GCN2-mediated signaling
negative regulation of GCN2-mediated signaling SubClassOf regulation of cellular response to stress
negative regulation of GCN2-mediated signaling SubClassOf negative regulation of intracellular signal transduction

negative regulation of L-glutamate biosynthetic process `http://purl.obolibrary.org/obo/GO_0140387`

Added

negative regulation of L-glutamate biosynthetic process has_broad_synonym “negative regulation of glutamate biosynthetic process”
negative regulation of L-glutamate biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31582”^^anyURI
negative regulation of L-glutamate biosynthetic process label “negative regulation of L-glutamate biosynthetic process”
negative regulation of L-glutamate biosynthetic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of L-glutamate biosynthetic process.”
- database_cross_reference “PMID:16899818”
- database_cross_reference “PMID:29649217”
negative regulation of L-glutamate biosynthetic process has_obo_namespace “biological_process”
negative regulation of L-glutamate biosynthetic process has_broad_synonym “negative regulation of L-glutamate biosynthesis”
negative regulation of L-glutamate biosynthetic process id “GO:0140387”
negative regulation of L-glutamate biosynthetic process creation date “2026-02-17T08:55:47Z”
negative regulation of L-glutamate biosynthetic process created by “pg”
Class: negative regulation of L-glutamate biosynthetic process
negative regulation of L-glutamate biosynthetic process EquivalentTo biological regulation and (negatively regulates some L-glutamate biosynthetic process)
negative regulation of L-glutamate biosynthetic process SubClassOf negatively regulates some L-glutamate biosynthetic process
negative regulation of L-glutamate biosynthetic process SubClassOf negative regulation of small molecule metabolic process
negative regulation of L-glutamate biosynthetic process SubClassOf negative regulation of amino acid biosynthetic process

negative regulation of MAP kinase activity `http://purl.obolibrary.org/obo/GO_0043407`

Removed

negative regulation of MAP kinase activity definition “Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of MAP kinase activity definition “Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”

negative regulation of MAPK cascade `http://purl.obolibrary.org/obo/GO_0043409`

Removed

negative regulation of MAPK cascade definition “Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of MAPK cascade definition “Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.”
- database_cross_reference “GOC:curators”

negative regulation of MHC class I biosynthetic process `http://purl.obolibrary.org/obo/GO_0045344`

Removed

negative regulation of MHC class I biosynthetic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of MHC class I biosynthetic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I.”
- database_cross_reference “GOC:curators”

negative regulation of MHC class II biosynthetic process `http://purl.obolibrary.org/obo/GO_0045347`

Removed

negative regulation of MHC class II biosynthetic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of MHC class II biosynthetic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II.”
- database_cross_reference “GOC:curators”

negative regulation of Notch signaling pathway `http://purl.obolibrary.org/obo/GO_0045746`

Removed

negative regulation of Notch signaling pathway definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of Notch signaling pathway definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.”
- database_cross_reference “GOC:curators”

negative regulation of R7 cell differentiation `http://purl.obolibrary.org/obo/GO_0045677`

Removed

negative regulation of R7 cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of R7cell differentiation.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

negative regulation of R7 cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of R7cell differentiation.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

negative regulation of R8 cell differentiation `http://purl.obolibrary.org/obo/GO_0045680`

Removed

negative regulation of R8 cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of R8 cell differentiation.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

negative regulation of R8 cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of R8 cell differentiation.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

negative regulation of RNA polymerase II transcription preinitiation complex assembly `http://purl.obolibrary.org/obo/GO_0017055`

Removed

negative regulation of RNA polymerase II transcription preinitiation complex assembly definition “Any process that stops, prevents, or reduces the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of RNA polymerase II transcription preinitiation complex assembly definition “Any process that stops, prevents, or reduces the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.”
- database_cross_reference “GOC:curators”

negative regulation of T cell differentiation `http://purl.obolibrary.org/obo/GO_0045581`

Removed

negative regulation of T cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of T cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of T cell homeostatic proliferation `http://purl.obolibrary.org/obo/GO_0046014`

Removed

negative regulation of T cell homeostatic proliferation definition “Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of T cell homeostatic proliferation definition “Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation.”
- database_cross_reference “GOC:curators”

negative regulation of T-helper 1 cell differentiation `http://purl.obolibrary.org/obo/GO_0045626`

Removed

negative regulation of T-helper 1 cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 1 cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of T-helper 1 cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 1 cell differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of T-helper 2 cell differentiation `http://purl.obolibrary.org/obo/GO_0045629`

Removed

negative regulation of T-helper 2 cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 2 cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of T-helper 2 cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 2 cell differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of T-helper cell differentiation `http://purl.obolibrary.org/obo/GO_0045623`

Removed

negative regulation of T-helper cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of T-helper cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper cell differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of Toll signaling pathway `http://purl.obolibrary.org/obo/GO_0045751`

Removed

negative regulation of Toll signaling pathway definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the Tl signaling pathway.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of Toll signaling pathway definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the Tl signaling pathway.”
- database_cross_reference “GOC:curators”

negative regulation of Wnt signaling pathway `http://purl.obolibrary.org/obo/GO_0030178`

Removed

negative regulation of Wnt signaling pathway definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

negative regulation of Wnt signaling pathway definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

negative regulation of Wnt signaling pathway, calcium modulating pathway `http://purl.obolibrary.org/obo/GO_0045812`

Removed

negative regulation of Wnt signaling pathway, calcium modulating pathway definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

negative regulation of Wnt signaling pathway, calcium modulating pathway definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

negative regulation of acetate catabolic process `http://purl.obolibrary.org/obo/GO_0045753`

Removed

negative regulation of acetate catabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of acetate catabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate.”
- database_cross_reference “GOC:curators”

negative regulation of acetyl-CoA biosynthesis `http://purl.obolibrary.org/obo/GO_0140391`

Added

negative regulation of acetyl-CoA biosynthesis id “GO:0140391”
negative regulation of acetyl-CoA biosynthesis definition “Any process that stops, prevents or reduces the frequency, rate or extent of acetyl-CoA biosynthetic process.”
- database_cross_reference “PMID:39019872”
negative regulation of acetyl-CoA biosynthesis has_obo_namespace “biological_process”
negative regulation of acetyl-CoA biosynthesis creation date “2026-03-04T08:22:01Z”
negative regulation of acetyl-CoA biosynthesis term tracker item “https://github.com/geneontology/go-ontology/issues/31614”^^anyURI
negative regulation of acetyl-CoA biosynthesis label “negative regulation of acetyl-CoA biosynthesis”
negative regulation of acetyl-CoA biosynthesis created by “pg”
Class: negative regulation of acetyl-CoA biosynthesis
negative regulation of acetyl-CoA biosynthesis EquivalentTo biological regulation and (negatively regulates some acetyl-CoA biosynthetic process)
negative regulation of acetyl-CoA biosynthesis SubClassOf negatively regulates some acetyl-CoA biosynthetic process
negative regulation of acetyl-CoA biosynthesis SubClassOf negative regulation of small molecule metabolic process
negative regulation of acetyl-CoA biosynthesis SubClassOf negative regulation of nucleobase-containing compound metabolic process
negative regulation of acetyl-CoA biosynthesis SubClassOf negative regulation of phosphate metabolic process
negative regulation of acetyl-CoA biosynthesis SubClassOf negative regulation of biosynthetic process
negative regulation of acetyl-CoA biosynthesis SubClassOf regulation of acyl-CoA biosynthetic process

negative regulation of action potential `http://purl.obolibrary.org/obo/GO_0045759`

Removed

negative regulation of action potential definition “Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of action potential definition “Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.”
- database_cross_reference “GOC:curators”

negative regulation of activated T cell proliferation `http://purl.obolibrary.org/obo/GO_0046007`

Removed

negative regulation of activated T cell proliferation definition “Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of activated T cell proliferation definition “Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation.”
- database_cross_reference “GOC:curators”

negative regulation of adenylate cyclase activity `http://purl.obolibrary.org/obo/GO_0007194`

Removed

negative regulation of adenylate cyclase activity definition “Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of adenylate cyclase activity definition “Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity.”
- database_cross_reference “GOC:curators”

negative regulation of adult salivary gland boundary specification `http://purl.obolibrary.org/obo/GO_0045709`

Removed

negative regulation of adult salivary gland boundary specification definition “Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination in an adult organism.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

negative regulation of adult salivary gland boundary specification definition “Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination in an adult organism.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

negative regulation of alcohol biosynthetic process `http://purl.obolibrary.org/obo/GO_1902931`

Added

negative regulation of alcohol biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31485”^^anyURI
negative regulation of alcohol biosynthetic process in_subset gocheck_do_not_annotate

negative regulation of alcohol catabolic process `http://purl.obolibrary.org/obo/GO_1900420`

Added

negative regulation of alcohol catabolic process in_subset gocheck_do_not_annotate
negative regulation of alcohol catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31485”^^anyURI

negative regulation of amino acid metabolic process `http://purl.obolibrary.org/obo/GO_0045763`

Removed

negative regulation of amino acid metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of amino acid metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid.”
- database_cross_reference “GOC:curators”

negative regulation of ammonia assimilation cycle `http://purl.obolibrary.org/obo/GO_2001249`

Removed

negative regulation of ammonia assimilation cycle SubClassOf obsolete negative regulation of glutamate metabolic process

Added

negative regulation of amyloid precursor protein biosynthetic process `http://purl.obolibrary.org/obo/GO_0042985`

Removed

negative regulation of amyloid precursor protein biosynthetic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of amyloid precursor protein biosynthetic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.”
- database_cross_reference “GOC:curators”

negative regulation of angiogenesis `http://purl.obolibrary.org/obo/GO_0016525`

Removed

negative regulation of angiogenesis definition “Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of angiogenesis definition “Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.”
- database_cross_reference “GOC:curators”

negative regulation of antimicrobial humoral response `http://purl.obolibrary.org/obo/GO_0008348`

Removed

negative regulation of antimicrobial humoral response definition “Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of antimicrobial humoral response definition “Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response.”
- database_cross_reference “GOC:curators”

negative regulation of antipodal cell differentiation `http://purl.obolibrary.org/obo/GO_0045689`

Removed

negative regulation of antipodal cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of antipodal cell differentiation.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_plant”

Added

negative regulation of antipodal cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of antipodal cell differentiation.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_plant”

negative regulation of asymmetric cell division `http://purl.obolibrary.org/obo/GO_0045769`

Removed

negative regulation of asymmetric cell division definition “Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of asymmetric cell division definition “Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division.”
- database_cross_reference “GOC:curators”

negative regulation of auditory receptor cell fate specification `http://purl.obolibrary.org/obo/GO_0009999`

Removed

negative regulation of auditory receptor cell fate specification definition “Any process that restricts, stops or prevents a cell from specifying into an auditory hair cell.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of auditory receptor cell fate specification definition “Any process that restricts, stops or prevents a cell from specifying into an auditory hair cell.”
- database_cross_reference “GOC:curators”

negative regulation of autophagosome size `http://purl.obolibrary.org/obo/GO_0045771`

Removed

negative regulation of autophagosome size definition “Any process that reduces autophagosome size.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:autophagy”

Added

negative regulation of autophagosome size definition “Any process that reduces autophagosome size.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:autophagy”

negative regulation of basophil differentiation `http://purl.obolibrary.org/obo/GO_0045641`

Removed

negative regulation of basophil differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of basophil differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of basophil differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of basophil differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of beta 2 integrin biosynthetic process `http://purl.obolibrary.org/obo/GO_0045774`

Removed

negative regulation of beta 2 integrin biosynthetic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of beta 2 integrin biosynthetic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins.”
- database_cross_reference “GOC:curators”

negative regulation of bicoid mRNA localization `http://purl.obolibrary.org/obo/GO_0045853`

Removed

negative regulation of bicoid mRNA localization definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of bicoid mRNA localization definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location.”
- database_cross_reference “GOC:curators”

negative regulation of biosynthetic process `http://purl.obolibrary.org/obo/GO_0009890`

Removed

negative regulation of biosynthetic process definition “Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of biosynthetic process definition “Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.”
- database_cross_reference “GOC:curators”

negative regulation of blood pressure `http://purl.obolibrary.org/obo/GO_0045776`

Removed

negative regulation of blood pressure definition “Any process in which the force of blood traveling through the circulatory system is decreased.”
- database_cross_reference “GOC:mtg_cardio”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of blood pressure definition “Any process in which the force of blood traveling through the circulatory system is decreased.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_cardio”

negative regulation of blood vessel endothelial cell migration `http://purl.obolibrary.org/obo/GO_0043537`

Removed

negative regulation of blood vessel endothelial cell migration definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of blood vessel endothelial cell migration definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels.”
- database_cross_reference “GOC:curators”

negative regulation of bone mineralization `http://purl.obolibrary.org/obo/GO_0030502`

Removed

negative regulation of bone mineralization definition “Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of bone mineralization definition “Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization.”
- database_cross_reference “GOC:curators”

negative regulation of bone resorption `http://purl.obolibrary.org/obo/GO_0045779`

Removed

negative regulation of bone resorption definition “Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of bone resorption definition “Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption.”
- database_cross_reference “GOC:curators”

negative regulation of calcium ion-dependent exocytosis `http://purl.obolibrary.org/obo/GO_0045955`

Removed

negative regulation of calcium ion-dependent exocytosis definition “Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of calcium ion-dependent exocytosis definition “Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis.”
- database_cross_reference “GOC:curators”

negative regulation of carbohydrate metabolic process `http://purl.obolibrary.org/obo/GO_0045912`

Removed

negative regulation of carbohydrate metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of carbohydrate metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate.”
- database_cross_reference “GOC:curators”

negative regulation of cardioblast cell fate specification `http://purl.obolibrary.org/obo/GO_0009997`

Removed

negative regulation of cardioblast cell fate specification definition “Any process that restricts, stops or prevents a cell from specifying into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of cardioblast cell fate specification definition “Any process that restricts, stops or prevents a cell from specifying into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.”
- database_cross_reference “GOC:curators”

negative regulation of catabolic process `http://purl.obolibrary.org/obo/GO_0009895`

Removed

negative regulation of catabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of catabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances.”
- database_cross_reference “GOC:curators”

negative regulation of cell adhesion `http://purl.obolibrary.org/obo/GO_0007162`

Removed

negative regulation of cell adhesion definition “Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of cell adhesion definition “Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.”
- database_cross_reference “GOC:curators”

negative regulation of cell budding `http://purl.obolibrary.org/obo/GO_0045781`

Removed

negative regulation of cell budding definition “Any process that stops, prevents, or reduces the frequency, rate or extent of cell budding.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of cell budding definition “Any process that stops, prevents, or reduces the frequency, rate or extent of cell budding.”
- database_cross_reference “GOC:curators”

negative regulation of cell cycle `http://purl.obolibrary.org/obo/GO_0045786`

Removed

negative regulation of cell cycle definition “Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

negative regulation of cell cycle definition “Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

negative regulation of cell differentiation `http://purl.obolibrary.org/obo/GO_0045596`

Removed

negative regulation of cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of cell fate specification `http://purl.obolibrary.org/obo/GO_0009996`

Removed

negative regulation of cell fate specification definition “Any process that restricts, stops or prevents a cell from adopting a specific cell fate.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of cell fate specification definition “Any process that restricts, stops or prevents a cell from adopting a specific cell fate.”
- database_cross_reference “GOC:curators”

negative regulation of cell growth `http://purl.obolibrary.org/obo/GO_0030308`

Removed

negative regulation of cell growth definition “Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of cell growth definition “Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.”
- database_cross_reference “GOC:curators”

negative regulation of cell migration `http://purl.obolibrary.org/obo/GO_0030336`

Removed

negative regulation of cell migration definition “Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of cell migration definition “Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.”
- database_cross_reference “GOC:curators”

negative regulation of cell population proliferation `http://purl.obolibrary.org/obo/GO_0008285`

Removed

negative regulation of cell population proliferation definition “Any process that stops, prevents or reduces the rate or extent of cell proliferation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of cell population proliferation definition “Any process that stops, prevents or reduces the rate or extent of cell proliferation.”
- database_cross_reference “GOC:curators”

negative regulation of cell size `http://purl.obolibrary.org/obo/GO_0045792`

Removed

negative regulation of cell size definition “Any process that reduces cell size.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of cell size definition “Any process that reduces cell size.”
- database_cross_reference “GOC:curators”

negative regulation of cell volume `http://purl.obolibrary.org/obo/GO_0045794`

Removed

negative regulation of cell volume definition “Any process that decreases cell volume.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of cell volume definition “Any process that decreases cell volume.”
- database_cross_reference “GOC:curators”

negative regulation of chitin-based cuticle tanning `http://purl.obolibrary.org/obo/GO_0045800`

Removed

negative regulation of chitin-based cuticle tanning definition “Any process that stops, prevents, or reduces the frequency, rate or extent of chitin-based cuticular tanning.”
- database_cross_reference “GOC:jid”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_sensu”

Added

negative regulation of chitin-based cuticle tanning definition “Any process that stops, prevents, or reduces the frequency, rate or extent of chitin-based cuticular tanning.”
- database_cross_reference “GOC:jid”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_sensu”

negative regulation of cholesterol biosynthetic process `http://purl.obolibrary.org/obo/GO_0045541`

Removed

negative regulation of cholesterol biosynthetic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of cholesterol biosynthetic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.”
- database_cross_reference “GOC:curators”

negative regulation of circadian rhythm `http://purl.obolibrary.org/obo/GO_0042754`

Removed

negative regulation of circadian rhythm definition “Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of circadian rhythm definition “Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior.”
- database_cross_reference “GOC:curators”

negative regulation of circadian sleep/wake cycle, REM sleep `http://purl.obolibrary.org/obo/GO_0042322`

Removed

negative regulation of circadian sleep/wake cycle, REM sleep definition “Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of circadian sleep/wake cycle, REM sleep definition “Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:curators”

negative regulation of circadian sleep/wake cycle, sleep `http://purl.obolibrary.org/obo/GO_0042321`

Removed

negative regulation of circadian sleep/wake cycle, sleep definition “Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.”
- database_cross_reference “ISBN:0192800981”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of circadian sleep/wake cycle, sleep definition “Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.”
- database_cross_reference “ISBN:0192800981”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:curators”

negative regulation of complement activation `http://purl.obolibrary.org/obo/GO_0045916`

Removed

negative regulation of complement activation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of complement activation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation.”
- database_cross_reference “GOC:curators”

negative regulation of complement activation, alternative pathway `http://purl.obolibrary.org/obo/GO_0045957`

Removed

negative regulation of complement activation, alternative pathway definition “Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of complement activation, alternative pathway definition “Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway.”
- database_cross_reference “GOC:curators”

negative regulation of complement activation, classical pathway `http://purl.obolibrary.org/obo/GO_0045959`

Removed

negative regulation of complement activation, classical pathway definition “Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of complement activation, classical pathway definition “Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway.”
- database_cross_reference “GOC:curators”

negative regulation of crystal cell differentiation `http://purl.obolibrary.org/obo/GO_0042690`

Removed

negative regulation of crystal cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of crystal cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of crystal cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of crystal cell differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of cumulus cell differentiation `http://purl.obolibrary.org/obo/GO_0045593`

Removed

negative regulation of cumulus cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of ovarian cumulus cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of cumulus cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of ovarian cumulus cell differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of cyclin-dependent protein serine/threonine kinase activity `http://purl.obolibrary.org/obo/GO_0045736`

Removed

negative regulation of cyclin-dependent protein serine/threonine kinase activity definition “Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:pr”

Added

negative regulation of cyclin-dependent protein serine/threonine kinase activity definition “Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:pr”

negative regulation of cytolysis `http://purl.obolibrary.org/obo/GO_0045918`

Removed

negative regulation of cytolysis definition “Any process that stops, prevents, or reduces the frequency, rate or extent of cytolysis.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of cytolysis definition “Any process that stops, prevents, or reduces the frequency, rate or extent of cytolysis.”
- database_cross_reference “GOC:curators”

negative regulation of cytotoxic T cell differentiation `http://purl.obolibrary.org/obo/GO_0045584`

Removed

negative regulation of cytotoxic T cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of cytotoxic T cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of cytotoxic T cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of cytotoxic T cell differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of defense response to bacterium `http://purl.obolibrary.org/obo/GO_1900425`

Added

negative regulation of defense response to bacterium database_cross_reference “Reactome:R-HSA-9968551”
- label “Regulation of GBP-mediated host defense”

negative regulation of defense response to virus `http://purl.obolibrary.org/obo/GO_0050687`

Added

negative regulation of defense response to virus database_cross_reference “Reactome:R-HSA-168276”
- label “NS1 Mediated Effects on Host Pathways”
negative regulation of defense response to virus database_cross_reference “Reactome:R-HSA-164944”
- label “Nef and signal transduction”
negative regulation of defense response to virus database_cross_reference “Reactome:R-HSA-164938”
- label “Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters”

negative regulation of development, heterochronic `http://purl.obolibrary.org/obo/GO_0045961`

Removed

negative regulation of development, heterochronic definition “Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and decreases the rate at which this time point is reached.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of development, heterochronic definition “Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and decreases the rate at which this time point is reached.”
- database_cross_reference “GOC:curators”

negative regulation of developmental growth `http://purl.obolibrary.org/obo/GO_0048640`

Removed

negative regulation of developmental growth definition “Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of developmental growth definition “Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth.”
- database_cross_reference “GOC:curators”

negative regulation of dopamine metabolic process `http://purl.obolibrary.org/obo/GO_0045963`

Removed

negative regulation of dopamine metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of dopamine metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine.”
- database_cross_reference “GOC:curators”

negative regulation of ecdysteroid biosynthetic process `http://purl.obolibrary.org/obo/GO_0045997`

Removed

negative regulation of ecdysteroid biosynthetic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of ecdysteroid biosynthetic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids.”
- database_cross_reference “GOC:curators”

negative regulation of ecdysteroid secretion `http://purl.obolibrary.org/obo/GO_0045999`

Removed

negative regulation of ecdysteroid secretion definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of ecdysteroid.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of ecdysteroid secretion definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of ecdysteroid.”
- database_cross_reference “GOC:curators”

negative regulation of eclosion `http://purl.obolibrary.org/obo/GO_0045804`

Removed

negative regulation of eclosion definition “Any process that stops, prevents, or reduces the frequency, rate or extent of eclosion.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of eclosion definition “Any process that stops, prevents, or reduces the frequency, rate or extent of eclosion.”
- database_cross_reference “GOC:curators”

negative regulation of ectodermal cell fate specification `http://purl.obolibrary.org/obo/GO_0042666`

Removed

negative regulation of ectodermal cell fate specification definition “Any process that restricts, stops or prevents a cell from specifying into an ectoderm cell.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of ectodermal cell fate specification definition “Any process that restricts, stops or prevents a cell from specifying into an ectoderm cell.”
- database_cross_reference “GOC:curators”

negative regulation of embryo sac central cell differentiation `http://purl.obolibrary.org/obo/GO_0045692`

Removed

negative regulation of embryo sac central cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of embryo sac central cell differentiation.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_plant”

Added

negative regulation of embryo sac central cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of embryo sac central cell differentiation.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_plant”

negative regulation of embryo sac egg cell differentiation `http://purl.obolibrary.org/obo/GO_0045695`

Removed

negative regulation of embryo sac egg cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of embryo sac egg cell differentiation.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_plant”

Added

negative regulation of embryo sac egg cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of embryo sac egg cell differentiation.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_plant”

negative regulation of embryonic development `http://purl.obolibrary.org/obo/GO_0045992`

Removed

negative regulation of embryonic development definition “Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of embryonic development definition “Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development.”
- database_cross_reference “GOC:curators”

negative regulation of endocytosis `http://purl.obolibrary.org/obo/GO_0045806`

Removed

negative regulation of endocytosis definition “Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of endocytosis definition “Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis.”
- database_cross_reference “GOC:curators”

negative regulation of endodermal cell fate specification `http://purl.obolibrary.org/obo/GO_0042664`

Removed

negative regulation of endodermal cell fate specification definition “Any process that restricts, stops or prevents a cell from specifying into an endoderm cell.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of endodermal cell fate specification definition “Any process that restricts, stops or prevents a cell from specifying into an endoderm cell.”
- database_cross_reference “GOC:curators”

negative regulation of endopeptidase activity `http://purl.obolibrary.org/obo/GO_0010951`

Added

negative regulation of endopeptidase activity database_cross_reference “Reactome:R-HSA-5218900”
- label “CASP8 activity is inhibited”

negative regulation of endothelial cell differentiation `http://purl.obolibrary.org/obo/GO_0045602`

Removed

negative regulation of endothelial cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of endothelial cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of eosinophil differentiation `http://purl.obolibrary.org/obo/GO_0045644`

Removed

negative regulation of eosinophil differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of eosinophil differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of eosinophil differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of eosinophil differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of epidermal cell differentiation `http://purl.obolibrary.org/obo/GO_0045605`

Removed

negative regulation of epidermal cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of epidermal cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of epidermal growth factor receptor signaling pathway `http://purl.obolibrary.org/obo/GO_0042059`

Removed

negative regulation of epidermal growth factor receptor signaling pathway definition “Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of epidermal growth factor receptor signaling pathway definition “Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.”
- database_cross_reference “GOC:curators”

negative regulation of epidermal growth factor-activated receptor activity `http://purl.obolibrary.org/obo/GO_0007175`

Removed

negative regulation of epidermal growth factor-activated receptor activity definition “Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of epidermal growth factor-activated receptor activity definition “Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity.”
- database_cross_reference “GOC:curators”

negative regulation of epidermis development `http://purl.obolibrary.org/obo/GO_0045683`

Removed

negative regulation of epidermis development definition “Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of epidermis development definition “Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development.”
- database_cross_reference “GOC:curators”

negative regulation of erythrocyte differentiation `http://purl.obolibrary.org/obo/GO_0045647`

Removed

negative regulation of erythrocyte differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of erythrocyte differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of establishment of competence for transformation `http://purl.obolibrary.org/obo/GO_0045808`

Removed

negative regulation of establishment of competence for transformation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of competence for transformation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of establishment of competence for transformation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of competence for transformation.”
- database_cross_reference “GOC:curators”

negative regulation of exocytosis `http://purl.obolibrary.org/obo/GO_0045920`

Removed

negative regulation of exocytosis definition “Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of exocytosis definition “Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis.”
- database_cross_reference “GOC:curators”

negative regulation of fat cell differentiation `http://purl.obolibrary.org/obo/GO_0045599`

Removed

negative regulation of fat cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of fat cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of fatty acid biosynthetic process `http://purl.obolibrary.org/obo/GO_0045717`

Removed

negative regulation of fatty acid biosynthetic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of fatty acid biosynthetic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids.”
- database_cross_reference “GOC:curators”

negative regulation of fatty acid metabolic process `http://purl.obolibrary.org/obo/GO_0045922`

Removed

negative regulation of fatty acid metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of fatty acid metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.”
- database_cross_reference “GOC:curators”

negative regulation of fibroblast growth factor receptor signaling pathway `http://purl.obolibrary.org/obo/GO_0040037`

Removed

negative regulation of fibroblast growth factor receptor signaling pathway definition “Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of fibroblast growth factor receptor signaling pathway definition “Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.”
- database_cross_reference “GOC:curators”

negative regulation of flower development `http://purl.obolibrary.org/obo/GO_0009910`

Removed

negative regulation of flower development definition “Any process that stops, prevents, or reduces the frequency, rate or extent of flower development.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of flower development definition “Any process that stops, prevents, or reduces the frequency, rate or extent of flower development.”
- database_cross_reference “GOC:curators”

negative regulation of fusion of sperm to egg plasma membrane `http://purl.obolibrary.org/obo/GO_0043013`

Removed

negative regulation of fusion of sperm to egg plasma membrane SubClassOf negative regulation of cellular component organization

Added

negative regulation of fusion of sperm to egg plasma membrane SubClassOf negative regulation of cellular process

negative regulation of gamma-delta T cell differentiation `http://purl.obolibrary.org/obo/GO_0045587`

Removed

negative regulation of gamma-delta T cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of gamma-delta T cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of glial cell differentiation `http://purl.obolibrary.org/obo/GO_0045686`

Removed

negative regulation of glial cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of glial cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of gluconeogenesis `http://purl.obolibrary.org/obo/GO_0045721`

Removed

negative regulation of gluconeogenesis definition “Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of gluconeogenesis definition “Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.”
- database_cross_reference “GOC:curators”

negative regulation of glucose catabolic process to lactate via pyruvate `http://purl.obolibrary.org/obo/GO_1904024`

Removed

Added

negative regulation of glycogen biosynthetic process `http://purl.obolibrary.org/obo/GO_0045719`

Removed

negative regulation of glycogen biosynthetic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of glycogen biosynthetic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.”
- database_cross_reference “GOC:curators”

negative regulation of glycogen catabolic process `http://purl.obolibrary.org/obo/GO_0045818`

Removed

negative regulation of glycogen catabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of glycogen catabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.”
- database_cross_reference “GOC:curators”

negative regulation of glycolytic process `http://purl.obolibrary.org/obo/GO_0045820`

Removed

negative regulation of glycolytic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of glycolytic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis.”
- database_cross_reference “GOC:curators”

negative regulation of growth `http://purl.obolibrary.org/obo/GO_0045926`

Removed

negative regulation of growth definition “Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of growth definition “Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.”
- database_cross_reference “GOC:curators”

negative regulation of hair cycle `http://purl.obolibrary.org/obo/GO_0042636`

Removed

negative regulation of hair cycle definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair.”
- database_cross_reference “PMID:12230507”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of hair cycle definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair.”
- database_cross_reference “PMID:12230507”
- database_cross_reference “GOC:curators”

negative regulation of heart contraction `http://purl.obolibrary.org/obo/GO_0045822`

Removed

negative regulation of heart contraction definition “Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of heart contraction definition “Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction.”
- database_cross_reference “GOC:curators”

negative regulation of hemocyte differentiation `http://purl.obolibrary.org/obo/GO_0045611`

Removed

negative regulation of hemocyte differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of hemocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of hemocyte differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of hemocyte differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of imaginal disc growth `http://purl.obolibrary.org/obo/GO_0045571`

Removed

negative regulation of imaginal disc growth definition “Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc growth.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of imaginal disc growth definition “Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc growth.”
- database_cross_reference “GOC:curators”

negative regulation of innate immune response `http://purl.obolibrary.org/obo/GO_0045824`

Removed

negative regulation of innate immune response definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of innate immune response definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.”
- database_cross_reference “GOC:curators”

negative regulation of inner ear auditory receptor cell differentiation `http://purl.obolibrary.org/obo/GO_0045608`

Removed

negative regulation of inner ear auditory receptor cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of auditory hair cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of inner ear auditory receptor cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of auditory hair cell differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of integrin biosynthetic process `http://purl.obolibrary.org/obo/GO_0045720`

Removed

negative regulation of integrin biosynthetic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of integrin biosynthetic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins.”
- database_cross_reference “GOC:curators”

negative regulation of intestinal cholesterol absorption `http://purl.obolibrary.org/obo/GO_0045796`

Removed

negative regulation of intestinal cholesterol absorption definition “Any process that stops, prevents, or reduces the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of intestinal cholesterol absorption definition “Any process that stops, prevents, or reduces the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine.”
- database_cross_reference “GOC:curators”

negative regulation of isoprenoid metabolic process `http://purl.obolibrary.org/obo/GO_0045827`

Removed

negative regulation of isoprenoid metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of isoprenoid metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid.”
- database_cross_reference “GOC:curators”

negative regulation of isotype switching `http://purl.obolibrary.org/obo/GO_0045829`

Removed

negative regulation of isotype switching definition “Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of isotype switching definition “Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching.”
- database_cross_reference “GOC:curators”

negative regulation of juvenile hormone biosynthetic process `http://purl.obolibrary.org/obo/GO_0045968`

Removed

negative regulation of juvenile hormone biosynthetic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of juvenile hormone biosynthetic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone.”
- database_cross_reference “GOC:curators”

negative regulation of juvenile hormone catabolic process `http://purl.obolibrary.org/obo/GO_0045970`

Removed

negative regulation of juvenile hormone catabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of juvenile hormone catabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone.”
- database_cross_reference “GOC:curators”

negative regulation of juvenile hormone metabolic process `http://purl.obolibrary.org/obo/GO_0045928`

Removed

negative regulation of juvenile hormone metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of juvenile hormone metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone.”
- database_cross_reference “GOC:curators”

negative regulation of juvenile hormone secretion `http://purl.obolibrary.org/obo/GO_0045972`

Removed

negative regulation of juvenile hormone secretion definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of juvenile hormone.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of juvenile hormone secretion definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of juvenile hormone.”
- database_cross_reference “GOC:curators”

negative regulation of keratinocyte differentiation `http://purl.obolibrary.org/obo/GO_0045617`

Removed

negative regulation of keratinocyte differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of keratinocyte differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of larval salivary gland boundary specification `http://purl.obolibrary.org/obo/GO_0045710`

Removed

negative regulation of larval salivary gland boundary specification definition “Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination in a larval organism.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

negative regulation of larval salivary gland boundary specification definition “Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination in a larval organism.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

negative regulation of lipid metabolic process `http://purl.obolibrary.org/obo/GO_0045833`

Removed

negative regulation of lipid metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of lipid metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids.”
- database_cross_reference “GOC:curators”

negative regulation of locomotion `http://purl.obolibrary.org/obo/GO_0040013`

Removed

negative regulation of locomotion definition “Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of locomotion definition “Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism.”
- database_cross_reference “GOC:curators”

negative regulation of lymphocyte differentiation `http://purl.obolibrary.org/obo/GO_0045620`

Removed

negative regulation of lymphocyte differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of lymphocyte differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of macroautophagy `http://purl.obolibrary.org/obo/GO_0016242`

Removed

negative regulation of macroautophagy definition “Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of macroautophagy definition “Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy.”
- database_cross_reference “GOC:curators”

negative regulation of macrophage differentiation `http://purl.obolibrary.org/obo/GO_0045650`

Removed

negative regulation of macrophage differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of macrophage differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of mating-type specific transcription, DNA-templated `http://purl.obolibrary.org/obo/GO_0045894`

Removed

negative regulation of mating-type specific transcription, DNA-templated definition “Any mating-type specific process that stops, prevents or reduces the rate of cellular DNA-templated transcription.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:txnOH”

Added

negative regulation of mating-type specific transcription, DNA-templated definition “Any mating-type specific process that stops, prevents or reduces the rate of cellular DNA-templated transcription.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:txnOH”

negative regulation of mechanoreceptor differentiation `http://purl.obolibrary.org/obo/GO_0045632`

Removed

negative regulation of mechanoreceptor differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of mechanoreceptor differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of mechanoreceptor differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of mechanoreceptor differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of megakaryocyte differentiation `http://purl.obolibrary.org/obo/GO_0045653`

Removed

negative regulation of megakaryocyte differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of megakaryocyte differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of meiotic nuclear division `http://purl.obolibrary.org/obo/GO_0045835`

Removed

negative regulation of meiotic nuclear division definition “Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of meiotic nuclear division definition “Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis.”
- database_cross_reference “GOC:curators”

negative regulation of melanocyte differentiation `http://purl.obolibrary.org/obo/GO_0045635`

Removed

negative regulation of melanocyte differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of melanocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of melanocyte differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of melanocyte differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of membrane potential `http://purl.obolibrary.org/obo/GO_0045837`

Removed

negative regulation of membrane potential definition “Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of membrane potential definition “Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.”
- database_cross_reference “GOC:curators”

negative regulation of mesodermal cell fate specification `http://purl.obolibrary.org/obo/GO_0042662`

Removed

negative regulation of mesodermal cell fate specification definition “Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate specification.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of mesodermal cell fate specification definition “Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate specification.”
- database_cross_reference “GOC:curators”

negative regulation of metabolic process `http://purl.obolibrary.org/obo/GO_0009892`

Removed

negative regulation of metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.”
- database_cross_reference “GOC:curators”

negative regulation of mitotic cell cycle `http://purl.obolibrary.org/obo/GO_0045930`

Removed

negative regulation of mitotic cell cycle definition “Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

negative regulation of mitotic cell cycle definition “Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

negative regulation of mitotic cell cycle, embryonic `http://purl.obolibrary.org/obo/GO_0045976`

Removed

negative regulation of mitotic cell cycle, embryonic definition “Any process that stops, prevents or reduces the rate or extent of progression through the embryonic mitotic cell cycle.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

negative regulation of mitotic cell cycle, embryonic definition “Any process that stops, prevents or reduces the rate or extent of progression through the embryonic mitotic cell cycle.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

negative regulation of mitotic metaphase/anaphase transition `http://purl.obolibrary.org/obo/GO_0045841`

Removed

negative regulation of mitotic metaphase/anaphase transition definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of mitotic metaphase/anaphase transition definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.”
- database_cross_reference “GOC:curators”

negative regulation of mitotic nuclear division `http://purl.obolibrary.org/obo/GO_0045839`

Removed

negative regulation of mitotic nuclear division definition “Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

negative regulation of mitotic nuclear division definition “Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

negative regulation of mitotic recombination `http://purl.obolibrary.org/obo/GO_0045950`

Removed

negative regulation of mitotic recombination definition “Any process that inhibits or decreases the rate of DNA recombination during mitosis.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:hjd”

Added

negative regulation of mitotic recombination definition “Any process that inhibits or decreases the rate of DNA recombination during mitosis.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:hjd”

negative regulation of monocyte differentiation `http://purl.obolibrary.org/obo/GO_0045656`

Removed

negative regulation of monocyte differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of monocyte differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of muscle contraction `http://purl.obolibrary.org/obo/GO_0045932`

Removed

negative regulation of muscle contraction definition “Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of muscle contraction definition “Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction.”
- database_cross_reference “GOC:curators”

negative regulation of muscle organ development `http://purl.obolibrary.org/obo/GO_0048635`

Removed

negative regulation of muscle organ development definition “Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of muscle organ development definition “Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development.”
- database_cross_reference “GOC:curators”

negative regulation of myeloid cell differentiation `http://purl.obolibrary.org/obo/GO_0045638`

Removed

negative regulation of myeloid cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of myeloid cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of myoblast differentiation `http://purl.obolibrary.org/obo/GO_0045662`

Removed

negative regulation of myoblast differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “CL:0000056”
- database_cross_reference “GOC:mtg_muscle”

Added

negative regulation of myoblast differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.”
- database_cross_reference “GOC:curators”
- database_cross_reference “CL:0000056”
- database_cross_reference “GOC:mtg_muscle”

negative regulation of neuron apoptotic process `http://purl.obolibrary.org/obo/GO_0043524`

Removed

negative regulation of neuron apoptotic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_apoptosis”

Added

negative regulation of neuron apoptotic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_apoptosis”

negative regulation of neuron differentiation `http://purl.obolibrary.org/obo/GO_0045665`

Removed

negative regulation of neuron differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of neuron differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of neutrophil differentiation `http://purl.obolibrary.org/obo/GO_0045659`

Removed

negative regulation of neutrophil differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of neutrophil differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of neutrophil differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of neutrophil differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of nitric oxide biosynthetic process `http://purl.obolibrary.org/obo/GO_0045019`

Removed

negative regulation of nitric oxide biosynthetic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of nitric oxide biosynthetic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.”
- database_cross_reference “GOC:curators”

negative regulation of nitric oxide-cGMP mediated signal transduction `http://purl.obolibrary.org/obo/GO_0141151`

Removed

negative regulation of nitric oxide-cGMP mediated signal transduction SubClassOf obsolete negative regulation of nitric oxide mediated signal transduction

Added

negative regulation of nitric oxide-cGMP mediated signal transduction SubClassOf negative regulation of intracellular signal transduction

negative regulation of nitrogen utilization `http://purl.obolibrary.org/obo/GO_0045847`

Removed

negative regulation of nitrogen utilization definition “Any process that stops, prevents, or reduces the frequency, rate or extent of nitrogen utilization.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of nitrogen utilization definition “Any process that stops, prevents, or reduces the frequency, rate or extent of nitrogen utilization.”
- database_cross_reference “GOC:curators”

negative regulation of nucleobase-containing compound metabolic process `http://purl.obolibrary.org/obo/GO_0045934`

Removed

negative regulation of nucleobase-containing compound metabolic process definition “Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of nucleobase-containing compound metabolic process in_subset gocheck_do_not_annotate
negative regulation of nucleobase-containing compound metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31498”^^anyURI
negative regulation of nucleobase-containing compound metabolic process definition “Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.”
- database_cross_reference “GOC:curators”

negative regulation of nucleoside metabolic process `http://purl.obolibrary.org/obo/GO_0045978`

Removed

negative regulation of nucleoside metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleosides.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of nucleoside metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleosides.”
- database_cross_reference “GOC:curators”

negative regulation of nucleotide metabolic process `http://purl.obolibrary.org/obo/GO_0045980`

Removed

negative regulation of nucleotide metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of nucleotide metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.”
- database_cross_reference “GOC:curators”

negative regulation of nurse cell apoptotic process `http://purl.obolibrary.org/obo/GO_0045849`

Removed

negative regulation of nurse cell apoptotic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of nurse cell apoptotic process.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_apoptosis”

Added

negative regulation of nurse cell apoptotic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of nurse cell apoptotic process.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_apoptosis”

negative regulation of ossification `http://purl.obolibrary.org/obo/GO_0030279`

Removed

negative regulation of ossification definition “Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of ossification definition “Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.”
- database_cross_reference “GOC:curators”

negative regulation of osteoblast differentiation `http://purl.obolibrary.org/obo/GO_0045668`

Removed

negative regulation of osteoblast differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of osteoblast differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of osteoclast differentiation `http://purl.obolibrary.org/obo/GO_0045671`

Removed

negative regulation of osteoclast differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of osteoclast differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of phosphate metabolic process `http://purl.obolibrary.org/obo/GO_0045936`

Removed

negative regulation of phosphate metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of phosphate metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates.”
- database_cross_reference “GOC:curators”

negative regulation of phosphatidylinositol biosynthetic process `http://purl.obolibrary.org/obo/GO_0010512`

Removed

negative regulation of phosphatidylinositol biosynthetic process SubClassOf negative regulation of phospholipid biosynthetic process

Added

negative regulation of phosphorus utilization `http://purl.obolibrary.org/obo/GO_0045942`

Removed

negative regulation of phosphorus utilization definition “Any process that stops, prevents, or reduces the frequency, rate or extent of phosphorus utilization.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of phosphorus utilization definition “Any process that stops, prevents, or reduces the frequency, rate or extent of phosphorus utilization.”
- database_cross_reference “GOC:curators”

negative regulation of photoreceptor cell differentiation `http://purl.obolibrary.org/obo/GO_0046533`

Removed

negative regulation of photoreceptor cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of photoreceptor cell differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.”
- database_cross_reference “GOC:curators”

negative regulation of pinocytosis `http://purl.obolibrary.org/obo/GO_0048550`

Removed

negative regulation of pinocytosis definition “Any process that stops, prevents, or reduces the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally ‘cell drinking’. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of pinocytosis definition “Any process that stops, prevents, or reduces the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally ‘cell drinking’. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes.”
- database_cross_reference “GOC:curators”

negative regulation of plasmatocyte differentiation `http://purl.obolibrary.org/obo/GO_0045614`

Removed

negative regulation of plasmatocyte differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of plasmatocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of plasmatocyte differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of plasmatocyte differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of pole plasm oskar mRNA localization `http://purl.obolibrary.org/obo/GO_0045855`

Removed

negative regulation of pole plasm oskar mRNA localization definition “Any process that stops, prevents, or reduces the frequency, rate or extent of a process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of pole plasm oskar mRNA localization definition “Any process that stops, prevents, or reduces the frequency, rate or extent of a process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm.”
- database_cross_reference “GOC:curators”

negative regulation of preblastoderm mitotic cell cycle `http://purl.obolibrary.org/obo/GO_0046001`

Removed

negative regulation of preblastoderm mitotic cell cycle definition “Any process that stops, prevents or reduces the rate or extent of progression through the preblastoderm mitotic cell cycle.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

negative regulation of preblastoderm mitotic cell cycle definition “Any process that stops, prevents or reduces the rate or extent of progression through the preblastoderm mitotic cell cycle.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

negative regulation of protein kinase activity `http://purl.obolibrary.org/obo/GO_0006469`

Removed

negative regulation of protein kinase activity definition “Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of protein kinase activity definition “Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.”
- database_cross_reference “GOC:curators”

negative regulation of proteolysis `http://purl.obolibrary.org/obo/GO_0045861`

Removed

negative regulation of proteolysis definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of proteolysis definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.”
- database_cross_reference “GOC:curators”

negative regulation of purine nucleobase metabolic process `http://purl.obolibrary.org/obo/GO_0045982`

Removed

negative regulation of purine nucleobase metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving purine nucleobases.”
- database_cross_reference “GOC:go_curators”
negative regulation of purine nucleobase metabolic process has_exact_synonym “negative regulation of purine base metabolic process”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of purine nucleobase metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving purine nucleobases.”
- database_cross_reference “GOC:curators”
negative regulation of purine nucleobase metabolic process has_exact_synonym “negative regulation of purine base metabolic process”
- database_cross_reference “GOC:curators”

negative regulation of purine nucleotide biosynthetic process `http://purl.obolibrary.org/obo/GO_1900372`

Removed

negative regulation of purine nucleotide biosynthetic process definition “Any process that stops, prevents or reduces the frequency, rate or extent of purine nucleotide biosynthetic processes.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:TermGenie”

Added

negative regulation of purine nucleotide biosynthetic process definition “Any process that stops, prevents or reduces the frequency, rate or extent of purine nucleotide biosynthetic processes.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:TermGenie”

negative regulation of pyrimidine nucleobase metabolic process `http://purl.obolibrary.org/obo/GO_0045984`

Removed

negative regulation of pyrimidine nucleobase metabolic process has_exact_synonym “negative regulation of pyrimidine base metabolic process”
- database_cross_reference “GOC:go_curators”
negative regulation of pyrimidine nucleobase metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of pyrimidine nucleobase metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases.”
- database_cross_reference “GOC:curators”
negative regulation of pyrimidine nucleobase metabolic process has_exact_synonym “negative regulation of pyrimidine base metabolic process”
- database_cross_reference “GOC:curators”

negative regulation of pyruvate decarboxylation to acetyl-CoA `http://purl.obolibrary.org/obo/GO_0160218`

Removed

Added

negative regulation of pyruvate decarboxylation to acetyl-CoA SubClassOf negative regulation of acetyl-CoA biosynthesis

negative regulation of receptor-mediated endocytosis `http://purl.obolibrary.org/obo/GO_0048261`

Removed

negative regulation of receptor-mediated endocytosis definition “Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of receptor-mediated endocytosis definition “Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.”
- database_cross_reference “GOC:curators”

negative regulation of retinal cone cell fate specification `http://purl.obolibrary.org/obo/GO_0009998`

Removed

negative regulation of retinal cone cell fate specification definition “Any process that restricts, stops or prevents a cell from specifying into a retinal cone cell.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of retinal cone cell fate specification definition “Any process that restricts, stops or prevents a cell from specifying into a retinal cone cell.”
- database_cross_reference “GOC:curators”

negative regulation of salivary gland boundary specification `http://purl.obolibrary.org/obo/GO_0045705`

Removed

negative regulation of salivary gland boundary specification definition “Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

negative regulation of salivary gland boundary specification definition “Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

negative regulation of septation initiation signaling `http://purl.obolibrary.org/obo/GO_0031030`

Removed

negative regulation of septation initiation signaling SubClassOf negative regulation of division septum assembly

Added

negative regulation of septation initiation signaling term tracker item “https://github.com/geneontology/go-ontology/issues/31584”^^anyURI

negative regulation of sevenless signaling pathway `http://purl.obolibrary.org/obo/GO_0045873`

Removed

negative regulation of sevenless signaling pathway definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the sevenless signaling pathway.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of sevenless signaling pathway definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the sevenless signaling pathway.”
- database_cross_reference “GOC:curators”

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate `http://purl.obolibrary.org/obo/GO_0045869`

Removed

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate definition “Any process that stops, prevents, or reduces the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate definition “Any process that stops, prevents, or reduces the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate.”
- database_cross_reference “GOC:curators”

negative regulation of sister chromatid cohesion `http://purl.obolibrary.org/obo/GO_0045875`

Removed

negative regulation of sister chromatid cohesion definition “Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid cohesion.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of sister chromatid cohesion definition “Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid cohesion.”
- database_cross_reference “GOC:curators”

negative regulation of skeletal muscle tissue development `http://purl.obolibrary.org/obo/GO_0048642`

Removed

negative regulation of skeletal muscle tissue development definition “Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of skeletal muscle tissue development definition “Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development.”
- database_cross_reference “GOC:curators”

negative regulation of small molecule metabolic process `http://purl.obolibrary.org/obo/GO_0062014`

Added

negative regulation of small molecule metabolic process in_subset gocheck_do_not_annotate
negative regulation of small molecule metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31485”^^anyURI

negative regulation of smooth muscle contraction `http://purl.obolibrary.org/obo/GO_0045986`

Removed

negative regulation of smooth muscle contraction definition “Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of smooth muscle contraction definition “Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction.”
- database_cross_reference “GOC:curators”

negative regulation of smoothened signaling pathway `http://purl.obolibrary.org/obo/GO_0045879`

Removed

negative regulation of smoothened signaling pathway definition “Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of smoothened signaling pathway definition “Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.”
- database_cross_reference “GOC:curators”

negative regulation of spermatid nuclear differentiation `http://purl.obolibrary.org/obo/GO_0045701`

Removed

negative regulation of spermatid nuclear differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of spermatid nuclear differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of spermatid nuclear differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of spermatid nuclear differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of sporulation resulting in formation of a cellular spore `http://purl.obolibrary.org/obo/GO_0042174`

Removed

negative regulation of sporulation resulting in formation of a cellular spore definition “Any process that stops, prevents, or reduces the frequency, rate or extent of sporulation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of sporulation resulting in formation of a cellular spore definition “Any process that stops, prevents, or reduces the frequency, rate or extent of sporulation.”
- database_cross_reference “GOC:curators”

negative regulation of steroid metabolic process `http://purl.obolibrary.org/obo/GO_0045939`

Removed

negative regulation of steroid metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of steroid metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids.”
- database_cross_reference “GOC:curators”

negative regulation of striated muscle contraction `http://purl.obolibrary.org/obo/GO_0045988`

Removed

negative regulation of striated muscle contraction definition “Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of striated muscle contraction definition “Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction.”
- database_cross_reference “GOC:curators”

negative regulation of striated muscle tissue development `http://purl.obolibrary.org/obo/GO_0045843`

Removed

negative regulation of striated muscle tissue development definition “Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of striated muscle tissue development definition “Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development.”
- database_cross_reference “GOC:curators”

negative regulation of sulfur utilization `http://purl.obolibrary.org/obo/GO_0045882`

Removed

negative regulation of sulfur utilization definition “Any process that stops, prevents, or reduces the frequency, rate or extent of sulfur utilization.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of sulfur utilization definition “Any process that stops, prevents, or reduces the frequency, rate or extent of sulfur utilization.”
- database_cross_reference “GOC:curators”

negative regulation of synaptic assembly at neuromuscular junction `http://purl.obolibrary.org/obo/GO_0045886`

Removed

negative regulation of synaptic assembly at neuromuscular junction definition “Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic assembly at neuromuscular junction.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of synaptic assembly at neuromuscular junction definition “Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic assembly at neuromuscular junction.”
- database_cross_reference “GOC:curators”

negative regulation of syncytial blastoderm mitotic cell cycle `http://purl.obolibrary.org/obo/GO_0046003`

Removed

negative regulation of syncytial blastoderm mitotic cell cycle definition “Any process that stops, prevents or reduces the rate or extent of progression through the syncytial blastoderm mitotic cell cycle.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

negative regulation of syncytial blastoderm mitotic cell cycle definition “Any process that stops, prevents or reduces the rate or extent of progression through the syncytial blastoderm mitotic cell cycle.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

negative regulation of syncytium formation by plasma membrane fusion `http://purl.obolibrary.org/obo/GO_0034242`

Removed

negative regulation of syncytium formation by plasma membrane fusion SubClassOf negative regulation of developmental process

negative regulation of synergid differentiation `http://purl.obolibrary.org/obo/GO_0045698`

Removed

negative regulation of synergid differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of synergid cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of synergid differentiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of synergid cell differentiation.”
- database_cross_reference “GOC:curators”

negative regulation of tetrapyrrole biosynthetic process from glutamate `http://purl.obolibrary.org/obo/GO_1901411`

Removed

negative regulation of tetrapyrrole biosynthetic process from glutamate SubClassOf obsolete negative regulation of glutamate metabolic process

Added

negative regulation of transcription by RNA polymerase I `http://purl.obolibrary.org/obo/GO_0016479`

Removed

negative regulation of transcription by RNA polymerase I definition “Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase I.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of transcription by RNA polymerase I definition “Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase I.”
- database_cross_reference “GOC:curators”

negative regulation of transcription by RNA polymerase II `http://purl.obolibrary.org/obo/GO_0000122`

Removed

negative regulation of transcription by RNA polymerase II definition “Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:txnOH”

Added

negative regulation of transcription by RNA polymerase II definition “Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:txnOH”

negative regulation of transcription by RNA polymerase III `http://purl.obolibrary.org/obo/GO_0016480`

Removed

negative regulation of transcription by RNA polymerase III definition “Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase III.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of transcription by RNA polymerase III definition “Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase III.”
- database_cross_reference “GOC:curators”

negative regulation of translational elongation `http://purl.obolibrary.org/obo/GO_0045900`

Removed

negative regulation of translational elongation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of translational elongation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation.”
- database_cross_reference “GOC:curators”

negative regulation of translational initiation `http://purl.obolibrary.org/obo/GO_0045947`

Removed

negative regulation of translational initiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of translational initiation definition “Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation.”
- database_cross_reference “GOC:curators”

negative regulation of translational initiation by iron `http://purl.obolibrary.org/obo/GO_0045993`

Removed

negative regulation of translational initiation by iron definition “Any process involving iron that stops, prevents or reduces the rate of translational initiation.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of translational initiation by iron definition “Any process involving iron that stops, prevents or reduces the rate of translational initiation.”
- database_cross_reference “GOC:curators”

negative regulation of translational termination `http://purl.obolibrary.org/obo/GO_0045904`

Removed

negative regulation of translational termination definition “Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of translational termination definition “Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination.”
- database_cross_reference “GOC:curators”

negative regulation of uterine smooth muscle contraction `http://purl.obolibrary.org/obo/GO_0070473`

Removed

negative regulation of uterine smooth muscle contraction definition “Any process that decreases the frequency, rate or extent of uterine smooth muscle contraction.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of uterine smooth muscle contraction definition “Any process that decreases the frequency, rate or extent of uterine smooth muscle contraction.”
- database_cross_reference “GOC:curators”

negative regulation of vasoconstriction `http://purl.obolibrary.org/obo/GO_0045906`

Removed

negative regulation of vasoconstriction definition “Any process that stops, prevents, or reduces the frequency, rate or extent of vasoconstriction.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of vasoconstriction definition “Any process that stops, prevents, or reduces the frequency, rate or extent of vasoconstriction.”
- database_cross_reference “GOC:curators”

negative regulation of viral genome replication `http://purl.obolibrary.org/obo/GO_0045071`

Removed

negative regulation of viral genome replication definition “Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.”
- database_cross_reference “GOC:go_curators”

Added

negative regulation of viral genome replication definition “Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.”
- database_cross_reference “GOC:curators”

nematode pharyngeal muscle development `http://purl.obolibrary.org/obo/GO_0160096`

Removed

nematode pharyngeal muscle development definition “The process whose specific outcome is the progression of the nematode pharyngeal muscle over time, from its formation to the mature structure.”
- database_cross_reference “GOC:go_curators”

Added

nematode pharyngeal muscle development definition “The process whose specific outcome is the progression of the nematode pharyngeal muscle over time, from its formation to the mature structure.”
- database_cross_reference “GOC:curators”

network-forming collagen trimer `http://purl.obolibrary.org/obo/GO_0098642`

Added

network-forming collagen trimer SubClassOf extracellular protein-containing complex
network-forming collagen trimer SubClassOf part of some extracellular matrix

neuroblast activation `http://purl.obolibrary.org/obo/GO_0007407`

Removed

neuroblast activation definition “A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_sensu”

Added

neuroblast activation definition “A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_sensu”

neuroblast fate determination `http://purl.obolibrary.org/obo/GO_0007400`

Removed

neuroblast fate determination definition “The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus.”
- database_cross_reference “GOC:go_curators”

Added

neuroblast fate determination definition “The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus.”
- database_cross_reference “GOC:curators”

neuron cell-cell adhesion `http://purl.obolibrary.org/obo/GO_0007158`

Removed

neuron cell-cell adhesion definition “The attachment of a neuron to another cell via adhesion molecules.”
- database_cross_reference “GOC:go_curators”

Added

neuron cell-cell adhesion definition “The attachment of a neuron to another cell via adhesion molecules.”
- database_cross_reference “GOC:curators”

neuron migration `http://purl.obolibrary.org/obo/GO_0001764`

Removed

neuron migration definition “The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “CL:0000540”

Added

neuron migration definition “The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.”
- database_cross_reference “GOC:curators”
- database_cross_reference “CL:0000540”

neuron recognition `http://purl.obolibrary.org/obo/GO_0008038`

Removed

neuron recognition definition “The process in which a neuronal cell in a multicellular organism interprets its surroundings.”
- database_cross_reference “GOC:go_curators”

Added

neuron recognition definition “The process in which a neuronal cell in a multicellular organism interprets its surroundings.”
- database_cross_reference “GOC:curators”

neuronal cell body `http://purl.obolibrary.org/obo/GO_0043025`

Removed

neuronal cell body definition “The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.”
- database_cross_reference “GOC:go_curators”

Added

neuronal cell body definition “The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.”
- database_cross_reference “GOC:curators”

neuronal ribonucleoprotein granule `http://purl.obolibrary.org/obo/GO_0071598`

Removed

neuronal ribonucleoprotein granule definition “A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:19015237”
- database_cross_reference “GOC:BHF”
- database_cross_reference “PMID:20368989”

Added

neuronal ribonucleoprotein granule definition “A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:19015237”
- database_cross_reference “GOC:BHF”
- database_cross_reference “PMID:20368989”

neurotransmitter loading into synaptic vesicle `http://purl.obolibrary.org/obo/GO_0098700`

Added

neurotransmitter loading into synaptic vesicle SubClassOf intercellular transport

neurotransmitter receptor transport, endosome to postsynaptic membrane `http://purl.obolibrary.org/obo/GO_0098887`

Added

neurotransmitter receptor transport, endosome to postsynaptic membrane SubClassOf intercellular transport

neurotransmitter transport `http://purl.obolibrary.org/obo/GO_0006836`

Added

neurotransmitter transport database_cross_reference “Reactome:R-HSA-442660”
- label “SLC-mediated transport of neurotransmitters”

nickel-pincer nucleotide cofactor biosynthetic process `http://purl.obolibrary.org/obo/GO_7770034`

Removed

nickel-pincer nucleotide cofactor biosynthetic process exactMatch PWY-7928

Added

nickel-pincer nucleotide cofactor biosynthetic process narrowMatch PWY-8561
nickel-pincer nucleotide cofactor biosynthetic process database_cross_reference “MetaCyc:PWY-8561”
nickel-pincer nucleotide cofactor biosynthetic process narrowMatch PWY-7928
nickel-pincer nucleotide cofactor biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI

nicotianamine biosynthetic process `http://purl.obolibrary.org/obo/GO_0030418`

Removed

nicotianamine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of nicotianamine, 2(S),3’2(S),3’‘(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid.”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:10069850”

Added

nicotianamine biosynthetic process database_cross_reference “MetaCyc:PWY-5957”
nicotianamine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31510”^^anyURI
nicotianamine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of nicotianamine.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:10069850”

nicotianamine:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0033855`

Removed

nicotianamine:2-oxoglutarate transaminase activity label “nicotianamine aminotransferase activity”
nicotianamine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + nicotianamine = 3’‘-deamino-3’‘-oxonicotianamine + L-glutamate.”
- database_cross_reference “EC:2.6.1.80”
- database_cross_reference “RHEA:22104”

Added

nicotianamine:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
nicotianamine:2-oxoglutarate transaminase activity has_exact_synonym “nicotianamine aminotransferase activity”
nicotianamine:2-oxoglutarate transaminase activity label “nicotianamine:2-oxoglutarate transaminase activity”
nicotianamine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: nicotianamine + 2-oxoglutarate = 3’‘-deamino-3’‘-oxonicotianamine + L-glutamate.”
- database_cross_reference “RHEA:22104”

nicotinamide nucleotide biosynthetic process `http://purl.obolibrary.org/obo/GO_0019359`

Removed

nicotinamide nucleotide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide.”
- database_cross_reference “GOC:go_curators”

Added

nicotinamide nucleotide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide.”
- database_cross_reference “GOC:curators”

nicotinamide nucleotide biosynthetic process from niacinamide `http://purl.obolibrary.org/obo/GO_0019360`

Removed

nicotinamide nucleotide biosynthetic process from niacinamide definition “The chemical reactions and pathways resulting in the formation of nicotinamide nucleotide from other compounds, including niacinamide.”
- database_cross_reference “GOC:go_curators”

Added

nicotinamide nucleotide biosynthetic process from niacinamide definition “The chemical reactions and pathways resulting in the formation of nicotinamide nucleotide from other compounds, including niacinamide.”
- database_cross_reference “GOC:curators”

nicotinamide-nucleotide amidase activity `http://purl.obolibrary.org/obo/GO_0019159`

Removed

nicotinamide-nucleotide amidase activity definition “Catalysis of the reaction: beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinate D-ribonucleotide + NH3.”
- database_cross_reference “EC:3.5.1.42”

Added

nicotinamide-nucleotide amidase activity definition “Catalysis of the reaction: beta-nicotinamide D-ribonucleotide + H2O = nicotinate beta-D-ribonucleotide + NH4+.”
- database_cross_reference “RHEA:12400”

nicotinate catabolic process `http://purl.obolibrary.org/obo/GO_1901848`

Added

nicotinate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
nicotinate catabolic process narrowMatch PWY-5055
nicotinate catabolic process database_cross_reference “MetaCyc:PWY-5055”
nicotinate catabolic process narrowMatch PWY-5033
nicotinate catabolic process database_cross_reference “MetaCyc:PWY-722”
nicotinate catabolic process database_cross_reference “MetaCyc:PWY-5033”
nicotinate catabolic process narrowMatch PWY-722

nicotinate metabolic process `http://purl.obolibrary.org/obo/GO_1901847`

Added

nicotinate metabolic process database_cross_reference “Reactome:R-HSA-196807”
- label “Nicotinate metabolism”

nicotinate nucleotide biosynthetic process `http://purl.obolibrary.org/obo/GO_0019357`

Removed

nicotinate nucleotide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid).”
- database_cross_reference “GOC:go_curators”

Added

nicotinate nucleotide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid).”
- database_cross_reference “GOC:curators”

nicotinate nucleotide salvage `http://purl.obolibrary.org/obo/GO_0019358`

Removed

nicotinate nucleotide salvage definition “The generation of nicotinate nucleotide without de novo synthesis.”
- database_cross_reference “GOC:go_curators”

Added

nicotinate nucleotide salvage definition “The generation of nicotinate nucleotide without de novo synthesis.”
- database_cross_reference “GOC:curators”

nicotinate transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0090416`

Removed

nicotinate transmembrane transporter activity database_cross_reference “Reactome:R-HSA-8869603”
- label “SLC22A13 transports NCA from extracellular region to cytosol”

Added

nicotinate transmembrane transporter activity database_cross_reference “Reactome:R-HSA-8869603”
- label “SLC22A13 exchanges extracellular NCA for cytosolic urate”

nicotine catabolic process `http://purl.obolibrary.org/obo/GO_0019608`

Added

nicotine catabolic process narrowMatch P181-PWY
nicotine catabolic process narrowMatch PWY66-201
nicotine catabolic process database_cross_reference “MetaCyc:PWY66-221”
nicotine catabolic process narrowMatch PWY-6993
nicotine catabolic process database_cross_reference “MetaCyc:PWY66-201”
nicotine catabolic process database_cross_reference “MetaCyc:PWY-7128”
nicotine catabolic process database_cross_reference “MetaCyc:PWY-6993”
nicotine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
nicotine catabolic process narrowMatch PWY-7128
nicotine catabolic process narrowMatch PWY66-221

nitrate assimilation `http://purl.obolibrary.org/obo/GO_0042128`

Added

nitrate assimilation database_cross_reference “MetaCyc:PWY490-3”
nitrate assimilation narrowMatch PWY490-3
nitrate assimilation database_cross_reference “MetaCyc:PWY-5675”
nitrate assimilation term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
nitrate assimilation narrowMatch PWY-5675
nitrate assimilation narrowMatch PWY-381

nitrate reductase (quinone) activity `http://purl.obolibrary.org/obo/GO_0160182`

Added

nitrate reductase (quinone) activity database_cross_reference “RHEA:29119”
nitrate reductase (quinone) activity narrowMatch 29119
nitrate reductase (quinone) activity database_cross_reference “RHEA:29127”
nitrate reductase (quinone) activity narrowMatch 29127

nitric oxide dioxygenase activity, heme protein as donor `http://purl.obolibrary.org/obo/GO_0141118`

Added

nitric oxide dioxygenase activity, heme protein as donor database_cross_reference “Reactome:R-HSA-5340226”
- label “CYGB dioxygenates NO”

nitric oxide-cGMP-mediated signaling `http://purl.obolibrary.org/obo/GO_0038060`

Removed

nitric oxide-cGMP-mediated signaling SubClassOf obsolete nitric oxide mediated signal transduction

Added

nitric oxide-cGMP-mediated signaling SubClassOf intracellular signaling cassette

nitrilase activity `http://purl.obolibrary.org/obo/GO_0000257`

Removed

nitrilase activity definition “Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides.”
- database_cross_reference “GOC:kd”
- database_cross_reference “EC:3.5.5.1”

Added

nitrilase activity narrowMatch 40775
nitrilase activity narrowMatch 45784
nitrilase activity database_cross_reference “RHEA:40775”
nitrilase activity database_cross_reference “RHEA:45784”
nitrilase activity definition “Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH4+. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides.”
- database_cross_reference “RHEA:21724”

nitrile hydratase activity `http://purl.obolibrary.org/obo/GO_0018822`

Added

nitrile hydratase activity database_cross_reference “RHEA:85671”
nitrile hydratase activity narrowMatch 85611
nitrile hydratase activity database_cross_reference “RHEA:85603”
nitrile hydratase activity database_cross_reference “RHEA:85643”
nitrile hydratase activity database_cross_reference “RHEA:85651”
nitrile hydratase activity narrowMatch 85647
nitrile hydratase activity database_cross_reference “RHEA:85611”
nitrile hydratase activity database_cross_reference “RHEA:85647”
nitrile hydratase activity narrowMatch 85691
nitrile hydratase activity narrowMatch 85603
nitrile hydratase activity narrowMatch 85607
nitrile hydratase activity narrowMatch 85651
nitrile hydratase activity database_cross_reference “RHEA:85691”
nitrile hydratase activity database_cross_reference “RHEA:85655”
nitrile hydratase activity database_cross_reference “RHEA:85607”
nitrile hydratase activity database_cross_reference “RHEA:85695”
nitrile hydratase activity narrowMatch 85695
nitrile hydratase activity narrowMatch 85671
nitrile hydratase activity narrowMatch 85655
nitrile hydratase activity narrowMatch 85643

nitrogen fixation `http://purl.obolibrary.org/obo/GO_0009399`

Added

nitrogen fixation narrowMatch PWY-7576
nitrogen fixation narrowMatch N2FIX-PWY
nitrogen fixation database_cross_reference “MetaCyc:PWY-7576”
nitrogen fixation term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI

nitrogenase (flavodoxin) activity `http://purl.obolibrary.org/obo/GO_0050142`

Removed

nitrogenase (flavodoxin) activity definition “Catalysis of the reaction: 6 reduced flavodoxin + 6 H+ + N2 + n ATP = 6 oxidized flavodoxin + 2 NH3 + n ADP + n phosphate.”
- database_cross_reference “EC:1.19.6.1”
- database_cross_reference “MetaCyc:NITROGENASE-FLAVODOXIN-RXN”

Added

nitrogenase (flavodoxin) activity definition “Catalysis of the reaction: N2 + 4 reduced [flavodoxin] + 16 ATP + 16 H2O = 4 oxidized [flavodoxin] + H2 + 2 NH4+ + 16 ADP + 16 phosphate + 18 H+.”
- database_cross_reference “RHEA:15645”

non-canonical inflammasome complex assembly `http://purl.obolibrary.org/obo/GO_0160075`

Added

non-canonical inflammasome complex assembly database_cross_reference “Reactome:R-HSA-9948001”
- label “CASP4 inflammasome assembly”
non-canonical inflammasome complex assembly database_cross_reference “Reactome:R-HSA-9948011”
- label “CASP5 inflammasome assembly”

nor-spermidine biosynthetic process `http://purl.obolibrary.org/obo/GO_0045312`

Removed

nor-spermidine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane.”
- database_cross_reference “GOC:go_curators”

Added

nor-spermidine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31766”^^anyURI
nor-spermidine biosynthetic process database_cross_reference “MetaCyc:PWY-6562”
nor-spermidine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane.”
- database_cross_reference “GOC:curators”

norepinephrine:sodium symporter activity `http://purl.obolibrary.org/obo/GO_0005334`

Removed

norepinephrine:sodium symporter activity database_cross_reference “Reactome:R-HSA-443997”
- label “SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol”

Added

norepinephrine:sodium symporter activity database_cross_reference “Reactome:R-HSA-443997”
- label “SLC6A2 cotransports NAd, Na+,Cl- from extracellular region to cytosol”

nuclear export `http://purl.obolibrary.org/obo/GO_0051168`

Added

nuclear export SubClassOf intercellular transport

nuclear import signal receptor activity `http://purl.obolibrary.org/obo/GO_0061608`

Added

nuclear import signal receptor activity database_cross_reference “Reactome:R-HSA-2065550”
- label “SREBP1A,1C,2 binds Importin beta-1”

nuclear receptor activity `http://purl.obolibrary.org/obo/GO_0004879`

Added

nuclear receptor activity database_cross_reference “Reactome:R-HSA-8937169”
- label “AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm”
nuclear receptor activity database_cross_reference “Reactome:R-HSA-8937191”
- label “AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates”
nuclear receptor activity database_cross_reference “Reactome:R-HSA-8936849”
- label “AHR:2xHSP90:AIP:PTGES3 binds TCDD”
nuclear receptor activity database_cross_reference “Reactome:R-HSA-400143”
- label “Fatty acid ligands activate PPARA”

nuclear steroid receptor activity `http://purl.obolibrary.org/obo/GO_0003707`

Added

nuclear steroid receptor activity database_cross_reference “Reactome:R-HSA-8963915”
- label “1,25(OH)2D binds VDR”

nucleobase-containing compound biosynthetic process `http://purl.obolibrary.org/obo/GO_0034654`

Added

nucleobase-containing compound biosynthetic process in_subset gocheck_do_not_annotate
nucleobase-containing compound biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31498”^^anyURI

nucleobase-containing compound catabolic process `http://purl.obolibrary.org/obo/GO_0034655`

Added

nucleobase-containing compound catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31498”^^anyURI
nucleobase-containing compound catabolic process in_subset gocheck_do_not_annotate

nucleobase-containing compound metabolic process `http://purl.obolibrary.org/obo/GO_0006139`

Added

nucleobase-containing compound metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31498”^^anyURI
nucleobase-containing compound metabolic process in_subset gocheck_do_not_annotate

nucleocytoplasmic transport `http://purl.obolibrary.org/obo/GO_0006913`

Removed

nucleocytoplasmic transport definition “The directed movement of molecules between the nucleus and the cytoplasm.”
- database_cross_reference “GOC:go_curators”

Added

nucleocytoplasmic transport definition “The directed movement of molecules between the nucleus and the cytoplasm.”
- database_cross_reference “GOC:curators”

nucleoside diphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009133`

Removed

nucleoside diphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

nucleoside diphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

nucleoside diphosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009134`

Removed

nucleoside diphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

nucleoside diphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

nucleoside diphosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009132`

Removed

nucleoside diphosphate metabolic process definition “The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

nucleoside diphosphate metabolic process definition “The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

nucleoside monophosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009124`

Removed

nucleoside monophosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

nucleoside monophosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

nucleoside monophosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009125`

Removed

nucleoside monophosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

nucleoside monophosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

nucleoside monophosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009123`

Removed

nucleoside monophosphate metabolic process definition “The chemical reactions and pathways involving a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

nucleoside monophosphate metabolic process definition “The chemical reactions and pathways involving a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

nucleoside oxidase (hydrogen peroxide-forming) activity `http://purl.obolibrary.org/obo/GO_0033716`

Removed

nucleoside oxidase (hydrogen peroxide-forming) activity definition “Catalysis of the reactions: adenosine + 2 O2 = 9-riburonosyladenine + 2 hydrogen peroxide.”
- database_cross_reference “RHEA:15489”
- database_cross_reference “EC:1.1.3.39”

Added

nucleoside oxidase (hydrogen peroxide-forming) activity definition “Catalysis of the reaction: adenosine + 2 O2 + H2O = 9-riburonosyladenine + 2 H2O2 + H+.”
- database_cross_reference “RHEA:15489”

nucleoside phosphotransferase activity `http://purl.obolibrary.org/obo/GO_0050146`

Added

nucleoside phosphotransferase activity database_cross_reference “RHEA:69580”
nucleoside phosphotransferase activity narrowMatch 69580
nucleoside phosphotransferase activity narrowMatch 69572
nucleoside phosphotransferase activity database_cross_reference “RHEA:69572”

nucleoside triphosphate adenylate kinase activity `http://purl.obolibrary.org/obo/GO_0046899`

Added

nucleoside triphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009142`

Removed

nucleoside triphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

nucleoside triphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

nucleoside triphosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009143`

Removed

nucleoside triphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

nucleoside triphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

nucleoside triphosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009141`

Removed

nucleoside triphosphate metabolic process definition “The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

nucleoside triphosphate metabolic process definition “The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

nucleotide biosynthetic process `http://purl.obolibrary.org/obo/GO_0009165`

Removed

nucleotide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).”
- database_cross_reference “GOC:go_curators”

Added

nucleotide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).”
- database_cross_reference “GOC:curators”

nucleotide catabolic process `http://purl.obolibrary.org/obo/GO_0009166`

Removed

nucleotide catabolic process definition “The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).”
- database_cross_reference “GOC:go_curators”

Added

nucleotide catabolic process definition “The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).”
- database_cross_reference “GOC:curators”

nucleotide-binding leucine-rich repeat receptor complex `http://purl.obolibrary.org/obo/GO_7770053`

Added

nucleotide-binding leucine-rich repeat receptor complex id “GO:7770053”
nucleotide-binding leucine-rich repeat receptor complex definition “A protein complex that contains one or more nucleotide-binding leucine-rich repeat (NLR) proteins and functions as an intracellular innate immune receptor. Upon activation by pathogen effectors or danger signals, the complex oligomerizes with adaptor and effector proteins to trigger downstream immune responses including programmed cell death.”
- database_cross_reference “PMID:30948527”
- database_cross_reference “PMID:30948526”
- database_cross_reference “PMID:26355215”
nucleotide-binding leucine-rich repeat receptor complex has_exact_synonym “NLR receptor complex”
nucleotide-binding leucine-rich repeat receptor complex label “nucleotide-binding leucine-rich repeat receptor complex”
nucleotide-binding leucine-rich repeat receptor complex has_related_synonym “NOD-like receptor complex”
nucleotide-binding leucine-rich repeat receptor complex has_obo_namespace “cellular_component”
nucleotide-binding leucine-rich repeat receptor complex created by “dragon-ai-agent”
nucleotide-binding leucine-rich repeat receptor complex term tracker item “https://github.com/geneontology/go-ontology/issues/31604”^^anyURI
nucleotide-binding leucine-rich repeat receptor complex has_exact_synonym “NLR complex”
nucleotide-binding leucine-rich repeat receptor complex creation date “2026-02-19T17:46:49Z”
Class: nucleotide-binding leucine-rich repeat receptor complex
nucleotide-binding leucine-rich repeat receptor complex SubClassOf signaling receptor complex

nucleus `http://purl.obolibrary.org/obo/GO_0005634`

Removed

nucleus definition “A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell’s chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.”
- database_cross_reference “GOC:go_curators”

Added

nucleus definition “A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell’s chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.”
- database_cross_reference “GOC:curators”

o-succinylbenzoate-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0008756`

Removed

o-succinylbenzoate-CoA ligase activity SubClassOf acid-thiol ligase activity

obsolete (+)-delta-cadinene-8-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0102947`

Removed

obsolete (+)-delta-cadinene-8-hydroxylase activity label “(+)-delta-cadinene-8-hydroxylase activity”
obsolete (+)-delta-cadinene-8-hydroxylase activity database_cross_reference “MetaCyc:RXN-9045”
obsolete (+)-delta-cadinene-8-hydroxylase activity definition “Catalysis of the reaction: H+ + (+)-delta-cadinene + NADPH + O2 = 8-hydroxy-(+)-delta-cadinene + NADP + H2O.”
- database_cross_reference “GOC:pz”
obsolete (+)-delta-cadinene-8-hydroxylase activity SubClassOf oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

Added

obsolete (+)-delta-cadinene-8-hydroxylase activity label “obsolete (+)-delta-cadinene-8-hydroxylase activity”
obsolete (+)-delta-cadinene-8-hydroxylase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete (+)-delta-cadinene-8-hydroxylase activity definition “OBSOLETE. Catalysis of the reaction: H+ + (+)-delta-cadinene + NADPH + O2 = 8-hydroxy-(+)-delta-cadinene + NADP + H2O.”
- database_cross_reference “GOC:pz”
obsolete (+)-delta-cadinene-8-hydroxylase activity deprecated true
obsolete (+)-delta-cadinene-8-hydroxylase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI

obsolete (22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity `http://purl.obolibrary.org/obo/GO_0102135`

Removed

obsolete (22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity label “(22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity”
obsolete (22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity definition “Catalysis of the reaction: H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH + O2 = (22R,23R)-22,23-dihydroxy-campest-4-en-3-one + NADP + H2O.”
- database_cross_reference “GOC:pz”
obsolete (22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity database_cross_reference “MetaCyc:RXN-11530”
obsolete (22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity SubClassOf oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

Added

obsolete (22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete (22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity label “obsolete (22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity”
obsolete (22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity definition “OBSOLETE. Catalysis of the reaction: H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH + O2 = (22R,23R)-22,23-dihydroxy-campest-4-en-3-one + NADP + H2O.”
- database_cross_reference “GOC:pz”
obsolete (22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete (22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity deprecated true

obsolete (22S)-22-hydroxy-campesterol C-23 hydroxylase activity `http://purl.obolibrary.org/obo/GO_0102134`

Removed

obsolete (22S)-22-hydroxy-campesterol C-23 hydroxylase activity database_cross_reference “MetaCyc:RXN-11529”
obsolete (22S)-22-hydroxy-campesterol C-23 hydroxylase activity definition “Catalysis of the reaction: H+ + (22S)-22-hydroxycampesterol + NADPH + O2 = (22R,23R)-22,23-dihydroxycampesterol + NADP + H2O.”
- database_cross_reference “GOC:pz”
obsolete (22S)-22-hydroxy-campesterol C-23 hydroxylase activity label “(22S)-22-hydroxy-campesterol C-23 hydroxylase activity”
obsolete (22S)-22-hydroxy-campesterol C-23 hydroxylase activity SubClassOf oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

Added

obsolete (22S)-22-hydroxy-campesterol C-23 hydroxylase activity deprecated true
obsolete (22S)-22-hydroxy-campesterol C-23 hydroxylase activity label “obsolete (22S)-22-hydroxy-campesterol C-23 hydroxylase activity”
obsolete (22S)-22-hydroxy-campesterol C-23 hydroxylase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete (22S)-22-hydroxy-campesterol C-23 hydroxylase activity definition “OBSOLETE. Catalysis of the reaction: H+ + (22S)-22-hydroxycampesterol + NADPH + O2 = (22R,23R)-22,23-dihydroxycampesterol + NADP + H2O.”
- database_cross_reference “GOC:pz”
obsolete (22S)-22-hydroxy-campesterol C-23 hydroxylase activity comment “This term was obsoleted because it represents a specific substrate.”

obsolete (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity `http://purl.obolibrary.org/obo/GO_0052687`

Removed

obsolete (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity database_cross_reference “KEGG_REACTION:R06396”
obsolete (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity label “(3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity”
obsolete (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity definition “Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP + phosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA.”
- database_cross_reference “KEGG_REACTION:R06396”
obsolete (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity SubClassOf CoA-ligase activity
obsolete (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity SubClassOf acid-thiol ligase activity

Added

obsolete (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity definition “OBSOLETE. Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP + phosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA.”
- database_cross_reference “KEGG_REACTION:R06396”
obsolete (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity deprecated true
obsolete (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity label “obsolete (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity”

obsolete (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity `http://purl.obolibrary.org/obo/GO_0052688`

Removed

obsolete (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity database_cross_reference “KEGG_REACTION:R06515”
obsolete (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity label “(3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity”
obsolete (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity definition “Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + AMP + diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA.”
- database_cross_reference “KEGG_REACTION:R06515”
obsolete (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity SubClassOf acid-thiol ligase activity
obsolete (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity SubClassOf CoA-ligase activity

Added

obsolete (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity definition “OBSOLETE. Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + AMP + diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA.”
- database_cross_reference “KEGG_REACTION:R06515”
obsolete (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity label “obsolete (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity”
obsolete (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity deprecated true

obsolete (R)-lactaldehyde dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0102641`

Removed

obsolete (R)-lactaldehyde dehydrogenase activity definition “Catalysis of the reaction: (R)-propane-1,2-diol + NADP = (R)-lactaldehyde + NADPH + H+.”
- database_cross_reference “GOC:pz”
obsolete (R)-lactaldehyde dehydrogenase activity label “(R)-lactaldehyde dehydrogenase activity”
obsolete (R)-lactaldehyde dehydrogenase activity database_cross_reference “MetaCyc:RXN-15743”
obsolete (R)-lactaldehyde dehydrogenase activity SubClassOf oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Added

obsolete (R)-lactaldehyde dehydrogenase activity label “obsolete (R)-lactaldehyde dehydrogenase activity”
obsolete (R)-lactaldehyde dehydrogenase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete (R)-lactaldehyde dehydrogenase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete (R)-lactaldehyde dehydrogenase activity definition “OBSOLETE. Catalysis of the reaction: (R)-propane-1,2-diol + NADP = (R)-lactaldehyde + NADPH + H+.”
- database_cross_reference “GOC:pz”
obsolete (R)-lactaldehyde dehydrogenase activity deprecated true

obsolete 1-aminocyclopropane-1-carboxylate biosynthetic process `http://purl.obolibrary.org/obo/GO_0042218`

Removed

obsolete 1-aminocyclopropane-1-carboxylate biosynthetic process label “1-aminocyclopropane-1-carboxylate biosynthetic process”
obsolete 1-aminocyclopropane-1-carboxylate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants.”
- database_cross_reference “GOC:go_curators”
obsolete 1-aminocyclopropane-1-carboxylate biosynthetic process SubClassOf non-proteinogenic amino acid biosynthetic process
obsolete 1-aminocyclopropane-1-carboxylate biosynthetic process SubClassOf obsolete 1-aminocyclopropane-1-carboxylate metabolic process
obsolete 1-aminocyclopropane-1-carboxylate biosynthetic process SubClassOf alpha-amino acid biosynthetic process

Added

obsolete 1-aminocyclopropane-1-carboxylate biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants.”
- database_cross_reference “GOC:curators”
obsolete 1-aminocyclopropane-1-carboxylate biosynthetic process label “obsolete 1-aminocyclopropane-1-carboxylate biosynthetic process”
obsolete 1-aminocyclopropane-1-carboxylate biosynthetic process deprecated true
obsolete 1-aminocyclopropane-1-carboxylate biosynthetic process consider ethylene biosynthetic process
obsolete 1-aminocyclopropane-1-carboxylate biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31510”^^anyURI
obsolete 1-aminocyclopropane-1-carboxylate biosynthetic process comment “This term was obsoleted because it represents an intermediate in ethylene biosynthesis.”

obsolete 1-aminocyclopropane-1-carboxylate metabolic process `http://purl.obolibrary.org/obo/GO_0018871`

Removed

obsolete 1-aminocyclopropane-1-carboxylate metabolic process database_cross_reference “UM-BBD_pathwayID:acp”
obsolete 1-aminocyclopropane-1-carboxylate metabolic process label “1-aminocyclopropane-1-carboxylate metabolic process”
obsolete 1-aminocyclopropane-1-carboxylate metabolic process definition “The chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants.”
- database_cross_reference “UM-BBD_pathwayID:acp”
obsolete 1-aminocyclopropane-1-carboxylate metabolic process SubClassOf alpha-amino acid metabolic process
obsolete 1-aminocyclopropane-1-carboxylate metabolic process SubClassOf non-proteinogenic amino acid metabolic process

Added

obsolete 1-aminocyclopropane-1-carboxylate metabolic process deprecated true
obsolete 1-aminocyclopropane-1-carboxylate metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
obsolete 1-aminocyclopropane-1-carboxylate metabolic process consider 1-aminocyclopropane-1-carboxylate catabolic process
obsolete 1-aminocyclopropane-1-carboxylate metabolic process label “obsolete 1-aminocyclopropane-1-carboxylate metabolic process”
obsolete 1-aminocyclopropane-1-carboxylate metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31510”^^anyURI
obsolete 1-aminocyclopropane-1-carboxylate metabolic process definition “OBSOLETE. The chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants.”
- database_cross_reference “GOC:curators”

obsolete 1-penten-3-one reductase activity `http://purl.obolibrary.org/obo/GO_0102235`

Removed

obsolete 1-penten-3-one reductase activity definition “Catalysis of the reaction: 1-penten-3-one + NADPH + H+ = 1-pentan-3-one + NADP.”
- database_cross_reference “GOC:pz”
obsolete 1-penten-3-one reductase activity database_cross_reference “MetaCyc:RXN-12295”
obsolete 1-penten-3-one reductase activity label “1-penten-3-one reductase activity”
obsolete 1-penten-3-one reductase activity SubClassOf oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

Added

obsolete 1-penten-3-one reductase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete 1-penten-3-one reductase activity label “obsolete 1-penten-3-one reductase activity”
obsolete 1-penten-3-one reductase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete 1-penten-3-one reductase activity deprecated true
obsolete 1-penten-3-one reductase activity definition “OBSOLETE. Catalysis of the reaction: 1-penten-3-one + NADPH + H+ = 1-pentan-3-one + NADP.”
- database_cross_reference “GOC:pz”

obsolete 11-beta-hydroxysteroid dehydrogenase [NAD(P)+] activity `http://purl.obolibrary.org/obo/GO_0003845`

Removed

obsolete 11-beta-hydroxysteroid dehydrogenase [NAD(P)+] activity database_cross_reference “Reactome:R-HSA-194023”
- label “HSD11B2,HSD11B1 dimer oxidise CORT to COR”

obsolete 11alpha-30-dihydroxy beta-amyrin dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0102369`

Removed

obsolete 11alpha-30-dihydroxy beta-amyrin dehydrogenase activity database_cross_reference “MetaCyc:RXN-13491”
obsolete 11alpha-30-dihydroxy beta-amyrin dehydrogenase activity label “11alpha-30-dihydroxy beta-amyrin dehydrogenase activity”
obsolete 11alpha-30-dihydroxy beta-amyrin dehydrogenase activity definition “Catalysis of the reaction: 11alpha,30-dihydroxy-beta-amyrin + NADPH + O2 + H+ = 30-hydroxy-11-oxo-beta-amyrin + NADP + 2 H2O.”
- database_cross_reference “GOC:pz”
obsolete 11alpha-30-dihydroxy beta-amyrin dehydrogenase activity SubClassOf oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

Added

obsolete 11alpha-30-dihydroxy beta-amyrin dehydrogenase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete 11alpha-30-dihydroxy beta-amyrin dehydrogenase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete 11alpha-30-dihydroxy beta-amyrin dehydrogenase activity definition “OBSOLETE. Catalysis of the reaction: 11alpha,30-dihydroxy-beta-amyrin + NADPH + O2 + H+ = 30-hydroxy-11-oxo-beta-amyrin + NADP + 2 H2O.”
- database_cross_reference “GOC:pz”
obsolete 11alpha-30-dihydroxy beta-amyrin dehydrogenase activity label “obsolete 11alpha-30-dihydroxy beta-amyrin dehydrogenase activity”
obsolete 11alpha-30-dihydroxy beta-amyrin dehydrogenase activity deprecated true

obsolete 16-alpha-hydroxygypsogenate-UDP-glucosyltransferase activity `http://purl.obolibrary.org/obo/GO_0102937`

Removed

obsolete 16-alpha-hydroxygypsogenate-UDP-glucosyltransferase activity label “16-alpha-hydroxygypsogenate-UDP-glucosyltransferase activity”
obsolete 16-alpha-hydroxygypsogenate-UDP-glucosyltransferase activity definition “Catalysis of the reaction: UDP-alpha-D-glucose + 16-alpha-hydroxygypsogenate = 16-alpha-hydroxygypsogenate-28-beta-D-glucoside + UDP.”
- database_cross_reference “GOC:pz”
obsolete 16-alpha-hydroxygypsogenate-UDP-glucosyltransferase activity database_cross_reference “MetaCyc:RXN-9014”
obsolete 16-alpha-hydroxygypsogenate-UDP-glucosyltransferase activity SubClassOf hexosyltransferase activity

Added

obsolete 16-alpha-hydroxygypsogenate-UDP-glucosyltransferase activity deprecated true
obsolete 16-alpha-hydroxygypsogenate-UDP-glucosyltransferase activity label “obsolete 16-alpha-hydroxygypsogenate-UDP-glucosyltransferase activity”
obsolete 16-alpha-hydroxygypsogenate-UDP-glucosyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete 16-alpha-hydroxygypsogenate-UDP-glucosyltransferase activity definition “OBSOLETE. Catalysis of the reaction: UDP-alpha-D-glucose + 16-alpha-hydroxygypsogenate = 16-alpha-hydroxygypsogenate-28-beta-D-glucoside + UDP.”
- database_cross_reference “GOC:pz”
obsolete 16-alpha-hydroxygypsogenate-UDP-glucosyltransferase activity comment “This term was obsoleted because it represents a specific substrate.”

obsolete 2,5-dihydroxypyridine catabolic process to fumarate `http://purl.obolibrary.org/obo/GO_0019508`

Removed

obsolete 2,5-dihydroxypyridine catabolic process to fumarate database_cross_reference “MetaCyc:PWY-722”

obsolete 2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity `http://purl.obolibrary.org/obo/GO_0018755`

Removed

obsolete 2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity label “2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity”
obsolete 2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity definition “Catalysis of the reaction: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + OH- = 2,4-dihydroxy-6-amino-1,3,5-triazine + Cl-.”
- database_cross_reference “UM-BBD_reactionID:r1414”
obsolete 2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity database_cross_reference “UM-BBD_reactionID:r1414”
obsolete 2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity SubClassOf hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

Added

obsolete 2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete 2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity label “obsolete 2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity”
obsolete 2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity deprecated true
obsolete 2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity definition “OBSOLETE. Catalysis of the reaction: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + OH- = 2,4-dihydroxy-6-amino-1,3,5-triazine + Cl-.”
- database_cross_reference “GOC:curators”
obsolete 2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity comment “This term was obsoleted because it represents a specific substrate.”

obsolete 2-hydroxylaminobenzoate reductase activity `http://purl.obolibrary.org/obo/GO_0034557`

Removed

obsolete 2-hydroxylaminobenzoate reductase activity database_cross_reference “UM-BBD_reactionID:r0850”
obsolete 2-hydroxylaminobenzoate reductase activity database_cross_reference “MetaCyc:RXN-8848”
obsolete 2-hydroxylaminobenzoate reductase activity definition “Catalysis of the reaction: 2-hydroxylaminobenzoate + NAD(P)H = anthranilate + NAD(P)+ + H2O.”
- database_cross_reference “MetaCyc:RXN-8848”
obsolete 2-hydroxylaminobenzoate reductase activity label “2-hydroxylaminobenzoate reductase activity”
obsolete 2-hydroxylaminobenzoate reductase activity SubClassOf oxidoreductase activity, acting on the CH-NH2 group of donors

Added

obsolete 2-hydroxylaminobenzoate reductase activity definition “OBSOLETE. Catalysis of the reaction: 2-hydroxylaminobenzoate + NAD(P)H = anthranilate + NAD(P)+ + H2O.”
- database_cross_reference “GOC:curators”
obsolete 2-hydroxylaminobenzoate reductase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete 2-hydroxylaminobenzoate reductase activity label “obsolete 2-hydroxylaminobenzoate reductase activity”
obsolete 2-hydroxylaminobenzoate reductase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete 2-hydroxylaminobenzoate reductase activity deprecated true

obsolete 3-chlorobenzoate-4,5-oxygenase activity `http://purl.obolibrary.org/obo/GO_0102044`

Removed

obsolete 3-chlorobenzoate-4,5-oxygenase activity label “3-chlorobenzoate-4,5-oxygenase activity”
obsolete 3-chlorobenzoate-4,5-oxygenase activity definition “Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor = 3-chlorobenzoate-cis-4,5-diol + an oxidized electron acceptor.”
- database_cross_reference “GOC:pz”
obsolete 3-chlorobenzoate-4,5-oxygenase activity database_cross_reference “MetaCyc:RXN-10421”
obsolete 3-chlorobenzoate-4,5-oxygenase activity SubClassOf oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

Added

obsolete 3-chlorobenzoate-4,5-oxygenase activity deprecated true
obsolete 3-chlorobenzoate-4,5-oxygenase activity label “obsolete 3-chlorobenzoate-4,5-oxygenase activity”
obsolete 3-chlorobenzoate-4,5-oxygenase activity definition “OBSOLETE. Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor = 3-chlorobenzoate-cis-4,5-diol + an oxidized electron acceptor.”
- database_cross_reference “GOC:pz”
obsolete 3-chlorobenzoate-4,5-oxygenase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete 3-chlorobenzoate-4,5-oxygenase activity comment “This term was obsoleted because it represents a specific substrate.”

obsolete 3-cyano-L-alanine biosynthetic process `http://purl.obolibrary.org/obo/GO_1903560`

Removed

obsolete 3-cyano-L-alanine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of 3-cyano-L-alanine.”
- database_cross_reference “PMID:24100226”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:24843024”
- database_cross_reference “GO_REF:0000068”
- database_cross_reference “GOC:kmv”
obsolete 3-cyano-L-alanine biosynthetic process label “3-cyano-L-alanine biosynthetic process”
obsolete 3-cyano-L-alanine biosynthetic process SubClassOf non-proteinogenic amino acid biosynthetic process
obsolete 3-cyano-L-alanine biosynthetic process SubClassOf L-amino acid biosynthetic process
obsolete 3-cyano-L-alanine biosynthetic process SubClassOf nitrile biosynthetic process

Added

obsolete 3-cyano-L-alanine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31510”^^anyURI
obsolete 3-cyano-L-alanine biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of 3-cyano-L-alanine.”
- database_cross_reference “PMID:24100226”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:24843024”
- database_cross_reference “GO_REF:0000068”
- database_cross_reference “GOC:kmv”
obsolete 3-cyano-L-alanine biosynthetic process label “obsolete 3-cyano-L-alanine biosynthetic process”
obsolete 3-cyano-L-alanine biosynthetic process comment “The reason for merging the above terms is to clean up this branch, consistent to what has been done previously.”
obsolete 3-cyano-L-alanine biosynthetic process deprecated true

obsolete 3-cyano-L-alanine catabolic process `http://purl.obolibrary.org/obo/GO_1903559`

Removed

obsolete 3-cyano-L-alanine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of 3-cyano-L-alanine.”
- database_cross_reference “PMID:24100226”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:24843024”
- database_cross_reference “GO_REF:0000068”
- database_cross_reference “GOC:kmv”
obsolete 3-cyano-L-alanine catabolic process label “3-cyano-L-alanine catabolic process”
obsolete 3-cyano-L-alanine catabolic process SubClassOf nitrile catabolic process
obsolete 3-cyano-L-alanine catabolic process SubClassOf non-proteinogenic amino acid catabolic process
obsolete 3-cyano-L-alanine catabolic process SubClassOf L-amino acid catabolic process

Added

obsolete 3-cyano-L-alanine catabolic process label “obsolete 3-cyano-L-alanine catabolic process”
obsolete 3-cyano-L-alanine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of 3-cyano-L-alanine.”
- database_cross_reference “PMID:24100226”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:24843024”
- database_cross_reference “GO_REF:0000068”
- database_cross_reference “GOC:kmv”
obsolete 3-cyano-L-alanine catabolic process deprecated true
obsolete 3-cyano-L-alanine catabolic process comment “This term was obsoleted because there is no evidence that a specific pathway for 3-cyano-L-alanine degradation exists.”

obsolete 3-hydroxybutyryl-CoA thiolase activity `http://purl.obolibrary.org/obo/GO_0018712`

Removed

obsolete 3-hydroxybutyryl-CoA thiolase activity definition “Catalysis of the reaction: 3-hydroxy-5-oxohexanoyl-CoA + CoASH = 3-hydroxybutyryl-CoA + acetyl-CoA.”
- database_cross_reference “UM-BBD_reactionID:r0010”
obsolete 3-hydroxybutyryl-CoA thiolase activity database_cross_reference “MetaCyc:R7-RXN”
obsolete 3-hydroxybutyryl-CoA thiolase activity label “3-hydroxybutyryl-CoA thiolase activity”
obsolete 3-hydroxybutyryl-CoA thiolase activity database_cross_reference “UM-BBD_reactionID:r0010”
obsolete 3-hydroxybutyryl-CoA thiolase activity SubClassOf acyltransferase activity, transferring groups other than amino-acyl groups

Added

obsolete 3-hydroxybutyryl-CoA thiolase activity definition “OBSOLETE. Catalysis of the reaction: 3-hydroxy-5-oxohexanoyl-CoA + CoASH = 3-hydroxybutyryl-CoA + acetyl-CoA.”
- database_cross_reference “GOC:curators”
obsolete 3-hydroxybutyryl-CoA thiolase activity label “obsolete 3-hydroxybutyryl-CoA thiolase activity”
obsolete 3-hydroxybutyryl-CoA thiolase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete 3-hydroxybutyryl-CoA thiolase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete 3-hydroxybutyryl-CoA thiolase activity deprecated true

obsolete 3-hydroxyphenylacetate biosynthetic process `http://purl.obolibrary.org/obo/GO_0046233`

Removed

obsolete 3-hydroxyphenylacetate biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate.”
- database_cross_reference “GOC:curator”

Added

obsolete 3-hydroxyphenylacetate biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate.”
- database_cross_reference “GOC:curators”

obsolete 3-ketoglucose-reductase activity `http://purl.obolibrary.org/obo/GO_0048258`

Removed

obsolete 3-ketoglucose-reductase activity database_cross_reference “MetaCyc:KETOGLUCOSE-REDUCTASE-RXN”
obsolete 3-ketoglucose-reductase activity definition “Catalysis of the reaction: NADP+ + 3-dehydro-alpha-D-glucose = NADPH + alpha-D-glucose.”
- database_cross_reference “MetaCyc:KETOGLUCOSE-REDUCTASE-RXN”
obsolete 3-ketoglucose-reductase activity label “3-ketoglucose-reductase activity”
obsolete 3-ketoglucose-reductase activity SubClassOf oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Added

obsolete 3-ketoglucose-reductase activity label “obsolete 3-ketoglucose-reductase activity”
obsolete 3-ketoglucose-reductase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete 3-ketoglucose-reductase activity deprecated true
obsolete 3-ketoglucose-reductase activity definition “OBSOLETE. Catalysis of the reaction: NADP+ + 3-dehydro-alpha-D-glucose = NADPH + alpha-D-glucose.”
- database_cross_reference “GOC:curators”
obsolete 3-ketoglucose-reductase activity comment “This term was obsoleted because it represents a specific substrate.”

obsolete 3-ketopimelyl-CoA thiolase activity `http://purl.obolibrary.org/obo/GO_0018713`

Removed

obsolete 3-ketopimelyl-CoA thiolase activity definition “Catalysis of the reaction: 3-ketopimeloyl-CoA + CoA = glutaryl-CoA + acetyl-CoA.”
- database_cross_reference “UM-BBD_reactionID:r0197”
obsolete 3-ketopimelyl-CoA thiolase activity label “3-ketopimelyl-CoA thiolase activity”
obsolete 3-ketopimelyl-CoA thiolase activity database_cross_reference “MetaCyc:RXN-8032”
obsolete 3-ketopimelyl-CoA thiolase activity database_cross_reference “UM-BBD_reactionID:r0197”
obsolete 3-ketopimelyl-CoA thiolase activity SubClassOf acyltransferase activity, transferring groups other than amino-acyl groups

Added

obsolete 3-ketopimelyl-CoA thiolase activity definition “OBSOLETE. Catalysis of the reaction: 3-ketopimeloyl-CoA + CoA = glutaryl-CoA + acetyl-CoA.”
- database_cross_reference “GOC:curators”
obsolete 3-ketopimelyl-CoA thiolase activity deprecated true
obsolete 3-ketopimelyl-CoA thiolase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete 3-ketopimelyl-CoA thiolase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete 3-ketopimelyl-CoA thiolase activity label “obsolete 3-ketopimelyl-CoA thiolase activity”

obsolete 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity `http://purl.obolibrary.org/obo/GO_0036169`

Removed

obsolete 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity database_cross_reference “Reactome:R-HSA-2162195”
- label “COQ4 decarboxylates MHDB”

obsolete 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity `http://purl.obolibrary.org/obo/GO_0018815`

Removed

obsolete 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity label “3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity”
obsolete 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity database_cross_reference “UM-BBD_reactionID:r0051”
obsolete 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity definition “Catalysis of the reaction: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon + H2O = 2-oxobut-3-enanoate + 2,5,6-trihydroxy-3-methylpyridine.”
- database_cross_reference “MetaCyc:RXN-645”
- database_cross_reference “UM-BBD_reactionID:r0051”
obsolete 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity database_cross_reference “MetaCyc:RXN-645”
obsolete 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity SubClassOf hydro-lyase activity

Added

obsolete 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity definition “OBSOLETE. Catalysis of the reaction: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon + H2O = 2-oxobut-3-enanoate + 2,5,6-trihydroxy-3-methylpyridine.”
- database_cross_reference “GOC:curators”
obsolete 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity deprecated true
obsolete 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity label “obsolete 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity”
obsolete 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI

obsolete 4-aminobutyrate transaminase activity `http://purl.obolibrary.org/obo/GO_0003867`

Removed

obsolete 4-aminobutyrate transaminase activity database_cross_reference “Reactome:R-HSA-916855”
- label “PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA”

obsolete 4-hydroxybenzoate decaprenyltransferase activity `http://purl.obolibrary.org/obo/GO_0002083`

Removed

obsolete 4-hydroxybenzoate decaprenyltransferase activity database_cross_reference “Reactome:R-HSA-2162192”
- label “COQ2 ligates all-E-10PrP2 to PHB”

obsolete 4-hydroxyproline biosynthetic process `http://purl.obolibrary.org/obo/GO_0019472`

Removed

obsolete 4-hydroxyproline biosynthetic process label “4-hydroxyproline biosynthetic process”
obsolete 4-hydroxyproline biosynthetic process definition “The chemical reactions and pathways resulting in the formation of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline.”
- database_cross_reference “GOC:ai”
obsolete 4-hydroxyproline biosynthetic process SubClassOf non-proteinogenic amino acid biosynthetic process
obsolete 4-hydroxyproline biosynthetic process SubClassOf modified amino acid biosynthetic process
obsolete 4-hydroxyproline biosynthetic process SubClassOf alpha-amino acid biosynthetic process

Added

obsolete 4-hydroxyproline biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline.”
- database_cross_reference “GOC:ai”
obsolete 4-hydroxyproline biosynthetic process comment “The reason for merging the above terms is to clean up this branch, consistent to what has been done previously.”
obsolete 4-hydroxyproline biosynthetic process deprecated true
obsolete 4-hydroxyproline biosynthetic process label “obsolete 4-hydroxyproline biosynthetic process”
obsolete 4-hydroxyproline biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31510”^^anyURI

obsolete 4-nitrobenzyl alcohol oxidase activity `http://purl.obolibrary.org/obo/GO_0102038`

Removed

obsolete 4-nitrobenzyl alcohol oxidase activity label “4-nitrobenzyl alcohol oxidase activity”
obsolete 4-nitrobenzyl alcohol oxidase activity definition “Catalysis of the reaction: 4-nitrobenzyl alcohol + O2 = 4-nitrobenzaldehyde + hydrogen peroxide.”
- database_cross_reference “GOC:pz”
obsolete 4-nitrobenzyl alcohol oxidase activity SubClassOf oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

Added

obsolete 4-nitrobenzyl alcohol oxidase activity definition “OBSOLETE. Catalysis of the reaction: 4-nitrobenzyl alcohol + O2 = 4-nitrobenzaldehyde + hydrogen peroxide.”
- database_cross_reference “GOC:pz”
obsolete 4-nitrobenzyl alcohol oxidase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31530”^^anyURI
obsolete 4-nitrobenzyl alcohol oxidase activity deprecated true
obsolete 4-nitrobenzyl alcohol oxidase activity comment “This term was obsoleted because there is no evidence that this reaction exists.”
obsolete 4-nitrobenzyl alcohol oxidase activity label “obsolete 4-nitrobenzyl alcohol oxidase activity”

obsolete 4-nitrotoluene monooxygenase activity `http://purl.obolibrary.org/obo/GO_0102037`

Removed

obsolete 4-nitrotoluene monooxygenase activity database_cross_reference “MetaCyc:R361-RXN”
obsolete 4-nitrotoluene monooxygenase activity definition “Catalysis of the reaction: H+ + 4-nitrotoluene + NADH + O2 = 4-nitrobenzyl alcohol + NAD+ + H2O.”
- database_cross_reference “GOC:pz”
obsolete 4-nitrotoluene monooxygenase activity label “4-nitrotoluene monooxygenase activity”
obsolete 4-nitrotoluene monooxygenase activity SubClassOf oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

Added

obsolete 4-nitrotoluene monooxygenase activity label “obsolete 4-nitrotoluene monooxygenase activity”
obsolete 4-nitrotoluene monooxygenase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete 4-nitrotoluene monooxygenase activity deprecated true
obsolete 4-nitrotoluene monooxygenase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete 4-nitrotoluene monooxygenase activity definition “OBSOLETE. Catalysis of the reaction: H+ + 4-nitrotoluene + NADH + O2 = 4-nitrobenzyl alcohol + NAD+ + H2O.”
- database_cross_reference “GOC:pz”

obsolete 5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0033779`

Removed

obsolete 5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase activity definition “OBSOLETE. Catalysis of the reaction: 5beta-cholestane-3alpha,7alpha-diol + H+ + NADPH + O2 = 5beta-cholestane-3alpha,7alpha,12alpha-triol + H2O + NADP+.”
- database_cross_reference “GOC:curator”

Added

obsolete 5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase activity definition “OBSOLETE. Catalysis of the reaction: 5beta-cholestane-3alpha,7alpha-diol + H+ + NADPH + O2 = 5beta-cholestane-3alpha,7alpha,12alpha-triol + H2O + NADP+.”
- database_cross_reference “GOC:curators”

obsolete 5-methylcytosine biosynthetic process `http://purl.obolibrary.org/obo/GO_0046082`

Removed

obsolete 5-methylcytosine biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of 5-methylcytosine, a methylated base of DNA.”
- database_cross_reference “GOC:go_curators”

Added

obsolete 5-methylcytosine biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of 5-methylcytosine, a methylated base of DNA.”
- database_cross_reference “GOC:curators”

obsolete 5-methylcytosine catabolic process `http://purl.obolibrary.org/obo/GO_0006211`

Removed

obsolete 5-methylcytosine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of 5-methylcytosine, a methylated base of DNA.”
- database_cross_reference “GOC:go_curators”

Added

obsolete 5-methylcytosine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of 5-methylcytosine, a methylated base of DNA.”
- database_cross_reference “GOC:curators”

obsolete 5-oxovalerate dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0055043`

Removed

obsolete 5-oxovalerate dehydrogenase activity label “5-oxovalerate dehydrogenase activity”
obsolete 5-oxovalerate dehydrogenase activity definition “Catalysis of the reaction: 5-oxovalerate + NADP+ + H2O = glutarate + NADPH + H+.”
- database_cross_reference “GOC:jid”
- database_cross_reference “GOC:mlg”
obsolete 5-oxovalerate dehydrogenase activity SubClassOf oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

Added

obsolete 5-oxovalerate dehydrogenase activity definition “OBSOLETE. Catalysis of the reaction: 5-oxovalerate + NADP+ + H2O = glutarate + NADPH + H+.”
- database_cross_reference “GOC:jid”
- database_cross_reference “GOC:mlg”
obsolete 5-oxovalerate dehydrogenase activity label “obsolete 5-oxovalerate dehydrogenase activity”
obsolete 5-oxovalerate dehydrogenase activity deprecated true
obsolete 5-oxovalerate dehydrogenase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete 5-oxovalerate dehydrogenase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI

obsolete 5-ureido-4-imidazole carboxylate hydrolase activity `http://purl.obolibrary.org/obo/GO_0043730`

Removed

obsolete 5-ureido-4-imidazole carboxylate hydrolase activity label “5-ureido-4-imidazole carboxylate hydrolase activity”
obsolete 5-ureido-4-imidazole carboxylate hydrolase activity definition “Catalysis of the reaction: 5-ureido-4-imidazole carboxylate + H2O = 5-amino-4-imidazole carboxylate + NH3 + CO2.”
- database_cross_reference “GOC:jl”
obsolete 5-ureido-4-imidazole carboxylate hydrolase activity SubClassOf hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

Added

obsolete 5-ureido-4-imidazole carboxylate hydrolase activity deprecated true
obsolete 5-ureido-4-imidazole carboxylate hydrolase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31530”^^anyURI
obsolete 5-ureido-4-imidazole carboxylate hydrolase activity label “obsolete 5-ureido-4-imidazole carboxylate hydrolase activity”
obsolete 5-ureido-4-imidazole carboxylate hydrolase activity definition “OBSOLETE. Catalysis of the reaction: 5-ureido-4-imidazole carboxylate + H2O = 5-amino-4-imidazole carboxylate + NH3 + CO2.”
- database_cross_reference “GOC:jl”
obsolete 5-ureido-4-imidazole carboxylate hydrolase activity comment “This term was obsoleted because there is no evidence that this reaction exists.”

obsolete 5-valerolactone hydrolase activity `http://purl.obolibrary.org/obo/GO_0055042`

Removed

obsolete 5-valerolactone hydrolase activity label “5-valerolactone hydrolase activity”
obsolete 5-valerolactone hydrolase activity definition “Catalysis of the reaction: 5-valerolactone + H2O = 5-hydroxyvalerate.”
- database_cross_reference “GOC:jid”
- database_cross_reference “GOC:mlg”
obsolete 5-valerolactone hydrolase activity SubClassOf lactonohydrolase activity

Added

obsolete 5-valerolactone hydrolase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete 5-valerolactone hydrolase activity label “obsolete 5-valerolactone hydrolase activity”
obsolete 5-valerolactone hydrolase activity deprecated true
obsolete 5-valerolactone hydrolase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete 5-valerolactone hydrolase activity definition “OBSOLETE. Catalysis of the reaction: 5-valerolactone + H2O = 5-hydroxyvalerate.”
- database_cross_reference “GOC:jid”
- database_cross_reference “GOC:mlg”

obsolete 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0033778`

Removed

obsolete 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase activity database_cross_reference “Reactome:R-HSA-192157”
- label “CYP8B1 12-hydroxylates 4CHOL7aOLONE”
obsolete 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase activity database_cross_reference “Reactome:R-HSA-193845”
- label “CYP8B1 12-hydroxylates 4CHOL7a,27DONE”
obsolete 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase activity database_cross_reference “Reactome:R-HSA-193709”
- label “CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL”

obsolete 8-oxo-dADP diphosphate phosphatase activity `http://purl.obolibrary.org/obo/GO_0102459`

Removed

obsolete 8-oxo-dADP diphosphate phosphatase activity database_cross_reference “MetaCyc:RXN-14005”
obsolete 8-oxo-dADP diphosphate phosphatase activity label “8-oxo-dADP diphosphate phosphatase activity”
obsolete 8-oxo-dADP diphosphate phosphatase activity definition “Catalysis of the reaction: 8-oxo-dADP + H2O = 8-oxo-dAMP + hydrogenphosphate + H+.”
- database_cross_reference “GOC:pz”
obsolete 8-oxo-dADP diphosphate phosphatase activity SubClassOf nucleoside diphosphate phosphatase activity

Added

obsolete 8-oxo-dADP diphosphate phosphatase activity definition “OBSOLETE. Catalysis of the reaction: 8-oxo-dADP + H2O = 8-oxo-dAMP + hydrogenphosphate + H+.”
- database_cross_reference “GOC:pz”
obsolete 8-oxo-dADP diphosphate phosphatase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete 8-oxo-dADP diphosphate phosphatase activity deprecated true
obsolete 8-oxo-dADP diphosphate phosphatase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete 8-oxo-dADP diphosphate phosphatase activity label “obsolete 8-oxo-dADP diphosphate phosphatase activity”

obsolete 9,10-dihydroxystearate hydroxylase activity `http://purl.obolibrary.org/obo/GO_0103006`

Removed

obsolete 9,10-dihydroxystearate hydroxylase activity definition “Catalysis of the reaction: H+ + (9R,10S)-dihydroxystearate + O2 + NADPH = 9,10,18-trihydroxystearate + H2O + NADP.”
- database_cross_reference “GOC:pz”
obsolete 9,10-dihydroxystearate hydroxylase activity database_cross_reference “MetaCyc:RXN-9807”
obsolete 9,10-dihydroxystearate hydroxylase activity label “9,10-dihydroxystearate hydroxylase activity”
obsolete 9,10-dihydroxystearate hydroxylase activity SubClassOf oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

Added

obsolete 9,10-dihydroxystearate hydroxylase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete 9,10-dihydroxystearate hydroxylase activity label “obsolete 9,10-dihydroxystearate hydroxylase activity”
obsolete 9,10-dihydroxystearate hydroxylase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete 9,10-dihydroxystearate hydroxylase activity definition “OBSOLETE. Catalysis of the reaction: H+ + (9R,10S)-dihydroxystearate + O2 + NADPH = 9,10,18-trihydroxystearate + H2O + NADP.”
- database_cross_reference “GOC:pz”
obsolete 9,10-dihydroxystearate hydroxylase activity deprecated true

obsolete 9,10-epoxystearate hydroxylase activity `http://purl.obolibrary.org/obo/GO_0103004`

Removed

obsolete 9,10-epoxystearate hydroxylase activity database_cross_reference “MetaCyc:RXN-9805”
obsolete 9,10-epoxystearate hydroxylase activity label “9,10-epoxystearate hydroxylase activity”
obsolete 9,10-epoxystearate hydroxylase activity definition “Catalysis of the reaction: H+ + 9,10-epoxystearate + O2 + NADPH = 9,10-epoxy-18-hydroxystearate + H2O + NADP.”
- database_cross_reference “GOC:pz”
obsolete 9,10-epoxystearate hydroxylase activity SubClassOf oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

Added

obsolete 9,10-epoxystearate hydroxylase activity label “obsolete 9,10-epoxystearate hydroxylase activity”
obsolete 9,10-epoxystearate hydroxylase activity deprecated true
obsolete 9,10-epoxystearate hydroxylase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete 9,10-epoxystearate hydroxylase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete 9,10-epoxystearate hydroxylase activity definition “OBSOLETE. Catalysis of the reaction: H+ + 9,10-epoxystearate + O2 + NADPH = 9,10-epoxy-18-hydroxystearate + H2O + NADP.”
- database_cross_reference “GOC:pz”

obsolete AT binding `http://purl.obolibrary.org/obo/GO_0006328`

Removed

obsolete AT binding definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete AT binding definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete ATPase-coupled inorganic anion transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0043225`

Removed

obsolete ATPase-coupled inorganic anion transmembrane transporter activity database_cross_reference “Reactome:R-HSA-5690340”
- label “Defective ABCC6 does not transport organic anion from cytosol to extracellular region”
obsolete ATPase-coupled inorganic anion transmembrane transporter activity database_cross_reference “Reactome:R-HSA-1454916”
- label “The ABCC family mediates organic anion transport”

obsolete CD4 biosynthetic process `http://purl.obolibrary.org/obo/GO_0045222`

Removed

obsolete CD4 biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

obsolete CD4 biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

obsolete COPII vesicle `http://purl.obolibrary.org/obo/GO_0005800`

Removed

obsolete COPII vesicle definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete COPII vesicle definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete CP2 mannose-ethanolamine phosphotransferase activity `http://purl.obolibrary.org/obo/GO_0051267`

Removed

obsolete CP2 mannose-ethanolamine phosphotransferase activity label “CP2 mannose-ethanolamine phosphotransferase activity”
obsolete CP2 mannose-ethanolamine phosphotransferase activity definition “Catalysis of the reaction: ethanolamine phosphate + Man-alpha-(1,2)-Man-alpha-(1,2)-Man-alpha-(1,6)-R = Man-alpha-(1,2)-Man-alpha-6-P-EtN-(1,2)-Man-alpha-(1,6)-R; R is Man-alpha(1,4)-GlcNH2-inositol-phosphate-lipid. This reaction is the transfer of ethanolamine phosphate to C6 of second mannose in the GPI lipid precursor CP2.”
- database_cross_reference “PMID:15452134”
- database_cross_reference “PMID:14985347”
obsolete CP2 mannose-ethanolamine phosphotransferase activity SubClassOf mannose-ethanolamine phosphotransferase activity

Added

obsolete CP2 mannose-ethanolamine phosphotransferase activity definition “OBSOLETE. Catalysis of the reaction: ethanolamine phosphate + Man-alpha-(1,2)-Man-alpha-(1,2)-Man-alpha-(1,6)-R = Man-alpha-(1,2)-Man-alpha-6-P-EtN-(1,2)-Man-alpha-(1,6)-R; R is Man-alpha(1,4)-GlcNH2-inositol-phosphate-lipid. This reaction is the transfer of ethanolamine phosphate to C6 of second mannose in the GPI lipid precursor CP2.”
- database_cross_reference “PMID:15452134”
- database_cross_reference “PMID:14985347”
obsolete CP2 mannose-ethanolamine phosphotransferase activity term replaced by mannose-ethanolamine phosphotransferase activity
obsolete CP2 mannose-ethanolamine phosphotransferase activity label “obsolete CP2 mannose-ethanolamine phosphotransferase activity”
obsolete CP2 mannose-ethanolamine phosphotransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31641”^^anyURI
obsolete CP2 mannose-ethanolamine phosphotransferase activity comment “This term was obsoleted because it represents the same process as its parent, mannose-ethanolamine phosphotransferase activity ; GO:0051377.”
obsolete CP2 mannose-ethanolamine phosphotransferase activity deprecated true

obsolete D-alanine metabolic process `http://purl.obolibrary.org/obo/GO_0046436`

Removed

obsolete D-alanine metabolic process label “D-alanine metabolic process”
obsolete D-alanine metabolic process definition “The chemical reactions and pathways involving D-alanine, the D-enantiomer of the amino acid alanine, i.e. (2R)-2-aminopropanoic acid.”
- database_cross_reference “GOC:jsg”
- database_cross_reference “GOC:ai”
obsolete D-alanine metabolic process SubClassOf D-amino acid metabolic process
obsolete D-alanine metabolic process SubClassOf obsolete alanine metabolic process

Added

obsolete D-alanine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving D-alanine, the D-enantiomer of the amino acid alanine, i.e. (2R)-2-aminopropanoic acid.”
- database_cross_reference “GOC:jsg”
- database_cross_reference “GOC:ai”
obsolete D-alanine metabolic process deprecated true
obsolete D-alanine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31357”^^anyURI
obsolete D-alanine metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
obsolete D-alanine metabolic process consider D-alanine catabolic process
obsolete D-alanine metabolic process label “obsolete D-alanine metabolic process”
obsolete D-alanine metabolic process consider D-alanine biosynthetic process

obsolete D-cysteine catabolic process `http://purl.obolibrary.org/obo/GO_0019447`

Removed

obsolete D-cysteine catabolic process label “D-cysteine catabolic process”
obsolete D-cysteine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of D-cysteine, (S)-2-amino-3-mercaptopropanoic acid, which occurs naturally in firefly luciferin.”
- database_cross_reference “PMID:11527960”
obsolete D-cysteine catabolic process SubClassOf D-amino acid catabolic process
obsolete D-cysteine catabolic process SubClassOf obsolete cysteine metabolic process
obsolete D-cysteine catabolic process SubClassOf sulfur amino acid catabolic process

Added

obsolete D-cysteine catabolic process label “obsolete D-cysteine catabolic process”
obsolete D-cysteine catabolic process deprecated true
obsolete D-cysteine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of D-cysteine, (S)-2-amino-3-mercaptopropanoic acid, which occurs naturally in firefly luciferin.”
- database_cross_reference “PMID:11527960”
obsolete D-cysteine catabolic process comment “This term was obsoleted because there is no evidence that there is a specific pathway to degrade D-cysteine.”
obsolete D-cysteine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31357”^^anyURI

obsolete D-erythro-sphingosine kinase activity `http://purl.obolibrary.org/obo/GO_0017050`

Removed

obsolete D-erythro-sphingosine kinase activity database_cross_reference “Reactome:R-HSA-9625814”
- label “SPHK1 phosphorylates sphingosine in response to E2 stimulation”
obsolete D-erythro-sphingosine kinase activity database_cross_reference “Reactome:R-HSA-5218845”
- label “p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate”

obsolete D-leucine biosynthetic process `http://purl.obolibrary.org/obo/GO_1900833`

Removed

obsolete D-leucine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of D-leucine.”
- database_cross_reference “PMID:10918062”
- database_cross_reference “GOC:TermGenie”
obsolete D-leucine biosynthetic process label “D-leucine biosynthetic process”
obsolete D-leucine biosynthetic process SubClassOf branched-chain amino acid biosynthetic process
obsolete D-leucine biosynthetic process SubClassOf D-amino acid biosynthetic process

Added

obsolete D-leucine biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of D-leucine.”
- database_cross_reference “PMID:10918062”
- database_cross_reference “GOC:TermGenie”
obsolete D-leucine biosynthetic process comment “The reason for merging the above terms is to clean up this branch, consistent to what has been done previously.”
obsolete D-leucine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31510”^^anyURI
obsolete D-leucine biosynthetic process label “obsolete D-leucine biosynthetic process”
obsolete D-leucine biosynthetic process deprecated true

obsolete D-leucine catabolic process `http://purl.obolibrary.org/obo/GO_1900832`

Removed

obsolete D-leucine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of D-leucine.”
- database_cross_reference “PMID:10918062”
- database_cross_reference “GOC:TermGenie”
obsolete D-leucine catabolic process label “D-leucine catabolic process”
obsolete D-leucine catabolic process SubClassOf D-amino acid catabolic process
obsolete D-leucine catabolic process SubClassOf branched-chain amino acid catabolic process

Added

obsolete D-leucine catabolic process comment “This term was obsoleted because there is no evidence that there is a specific pathway to degrade D-leucine.”
obsolete D-leucine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of D-leucine.”
- database_cross_reference “PMID:10918062”
- database_cross_reference “GOC:TermGenie”
obsolete D-leucine catabolic process deprecated true
obsolete D-leucine catabolic process label “obsolete D-leucine catabolic process”
obsolete D-leucine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31357”^^anyURI

obsolete D-lysine catabolic process `http://purl.obolibrary.org/obo/GO_0019476`

Removed

obsolete D-lysine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of D-lysine, the D-enantiomer of lysine; i.e. (2R)-2,6-diaminohexanoic acid.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:jsg”
- database_cross_reference “GOC:ai”
obsolete D-lysine catabolic process label “D-lysine catabolic process”
obsolete D-lysine catabolic process SubClassOf D-amino acid catabolic process
obsolete D-lysine catabolic process SubClassOf obsolete lysine metabolic process

Added

obsolete D-lysine catabolic process comment “This term was obsoleted because there is no evidence that there is a specific pathway to degrade D-lysine.”
obsolete D-lysine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of D-lysine, the D-enantiomer of lysine; i.e. (2R)-2,6-diaminohexanoic acid.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:jsg”
- database_cross_reference “GOC:ai”
obsolete D-lysine catabolic process deprecated true
obsolete D-lysine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31357”^^anyURI
obsolete D-lysine catabolic process label “obsolete D-lysine catabolic process”

obsolete D-serine metabolic process `http://purl.obolibrary.org/obo/GO_0070178`

Removed

obsolete D-serine metabolic process definition “The chemical reactions and pathways involving D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid.”
- database_cross_reference “GOC:mah”
- database_cross_reference “CHEBI:16523”
- database_cross_reference “GOC:jsg”
obsolete D-serine metabolic process label “D-serine metabolic process”
obsolete D-serine metabolic process SubClassOf D-amino acid metabolic process

Added

obsolete D-serine metabolic process consider D-serine biosynthetic process
obsolete D-serine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid.”
- database_cross_reference “GOC:mah”
- database_cross_reference “CHEBI:16523”
- database_cross_reference “GOC:jsg”
obsolete D-serine metabolic process consider D-serine catabolic process
obsolete D-serine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31357”^^anyURI
obsolete D-serine metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
obsolete D-serine metabolic process label “obsolete D-serine metabolic process”
obsolete D-serine metabolic process deprecated true

obsolete D-tyrosine catabolic process `http://purl.obolibrary.org/obo/GO_1900829`

Removed

obsolete D-tyrosine catabolic process label “D-tyrosine catabolic process”
obsolete D-tyrosine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of D-tyrosine.”
- database_cross_reference “PMID:10766779”
- database_cross_reference “GOC:TermGenie”
obsolete D-tyrosine catabolic process SubClassOf D-amino acid catabolic process
obsolete D-tyrosine catabolic process SubClassOf aromatic amino acid family catabolic process

Added

obsolete D-tyrosine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31357”^^anyURI
obsolete D-tyrosine catabolic process comment “This term was obsoleted because there is no evidence that there is a specific pathway to degrade D-tyrosine.”
obsolete D-tyrosine catabolic process deprecated true
obsolete D-tyrosine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of D-tyrosine.”
- database_cross_reference “PMID:10766779”
- database_cross_reference “GOC:TermGenie”
obsolete D-tyrosine catabolic process label “obsolete D-tyrosine catabolic process”

obsolete D-valine catabolic process `http://purl.obolibrary.org/obo/GO_1902079`

Removed

obsolete D-valine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of D-valine.”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:23085840”
obsolete D-valine catabolic process label “D-valine catabolic process”
obsolete D-valine catabolic process SubClassOf branched-chain amino acid catabolic process
obsolete D-valine catabolic process SubClassOf obsolete D-valine metabolic process
obsolete D-valine catabolic process SubClassOf D-amino acid catabolic process

Added

obsolete D-valine catabolic process deprecated true
obsolete D-valine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31357”^^anyURI
obsolete D-valine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of D-valine.”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:23085840”
obsolete D-valine catabolic process label “obsolete D-valine catabolic process”
obsolete D-valine catabolic process comment “This term was obsoleted because there is no evidence that there is a specific pathway to degrade D-valine.”

obsolete D-valine metabolic process `http://purl.obolibrary.org/obo/GO_1902114`

Removed

obsolete D-valine metabolic process label “D-valine metabolic process”
obsolete D-valine metabolic process definition “The chemical reactions and pathways involving D-valine.”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:23085840”
obsolete D-valine metabolic process SubClassOf D-amino acid metabolic process
obsolete D-valine metabolic process SubClassOf valine metabolic process

Added

obsolete D-valine metabolic process deprecated true
obsolete D-valine metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
obsolete D-valine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving D-valine.”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:23085840”
obsolete D-valine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31357”^^anyURI
obsolete D-valine metabolic process label “obsolete D-valine metabolic process”

obsolete DDT resistance `http://purl.obolibrary.org/obo/GO_0008163`

Removed

obsolete DDT resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete DDT resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete DNA damage response, detection of DNA damage `http://purl.obolibrary.org/obo/GO_0042769`

Removed

obsolete DNA damage response, detection of DNA damage definition “OBSOLETE. The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal.”
- database_cross_reference “GOC:go_curators”

Added

obsolete DNA damage response, detection of DNA damage definition “OBSOLETE. The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal.”
- database_cross_reference “GOC:curators”

obsolete DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest `http://purl.obolibrary.org/obo/GO_0006977`

Removed

obsolete DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest database_cross_reference “Reactome:R-HSA-6791312”
- label “TP53 Regulates Transcription of Cell Cycle Genes”
obsolete DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest definition “OBSOLETE. A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.”
- database_cross_reference “GOC:go_curators”
obsolete DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest database_cross_reference “Reactome:R-HSA-69563”
- label “p53-Dependent G1 DNA Damage Response”

Added

obsolete DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest definition “OBSOLETE. A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.”
- database_cross_reference “GOC:curators”

obsolete DNA methylation involved in gamete generation `http://purl.obolibrary.org/obo/GO_0043046`

Removed

obsolete DNA methylation involved in gamete generation definition “OBSOLETE. The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete.”
- database_cross_reference “PMID:12138111”
- database_cross_reference “GOC:go_curators”

Added

obsolete DNA methylation involved in gamete generation definition “OBSOLETE. The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:12138111”

obsolete DNA synthesis involved in double-strand break repair via single-strand annealing `http://purl.obolibrary.org/obo/GO_0043151`

Removed

obsolete DNA synthesis involved in double-strand break repair via single-strand annealing definition “OBSOLETE. The synthesis of DNA that contributes to the process of double-strand break repair via single-strand annealing.”
- database_cross_reference “GOC:go_curators”

Added

obsolete DNA synthesis involved in double-strand break repair via single-strand annealing definition “OBSOLETE. The synthesis of DNA that contributes to the process of double-strand break repair via single-strand annealing.”
- database_cross_reference “GOC:curators”

obsolete ER-Golgi transport vesicle `http://purl.obolibrary.org/obo/GO_0005805`

Removed

obsolete ER-Golgi transport vesicle definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete ER-Golgi transport vesicle definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete GSI anchor biosynthetic process `http://purl.obolibrary.org/obo/GO_0042082`

Removed

obsolete GSI anchor biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of a glycosylsphingolipidinositol (GSI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The sphingolipid group is linked, via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via a ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GSI anchors have variants on this canonical linkage.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:jsg”

Added

obsolete GSI anchor biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of a glycosylsphingolipidinositol (GSI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The sphingolipid group is linked, via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via a ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GSI anchors have variants on this canonical linkage.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:jsg”

obsolete GSI anchor metabolic process `http://purl.obolibrary.org/obo/GO_0042081`

Removed

obsolete GSI anchor metabolic process definition “OBSOLETE. The chemical reactions and pathways involving glycosylsphingolipidinositol (GSI) anchors, which attach membrane proteins to the lipid bilayer of the cell membrane.”
- database_cross_reference “GOC:go_curators”

Added

obsolete GSI anchor metabolic process definition “OBSOLETE. The chemical reactions and pathways involving glycosylsphingolipidinositol (GSI) anchors, which attach membrane proteins to the lipid bilayer of the cell membrane.”
- database_cross_reference “GOC:curators”

obsolete GTP:coenzyme F420 guanyltransferase activity `http://purl.obolibrary.org/obo/GO_0052754`

Removed

obsolete GTP:coenzyme F420 guanyltransferase activity label “GTP:coenzyme F420 guanyltransferase activity”
obsolete GTP:coenzyme F420 guanyltransferase activity exactMatch RXN-18273
obsolete GTP:coenzyme F420 guanyltransferase activity definition “Catalysis of the reaction: GTP + factor gamma-F420-2 + H+ = coenzyme F390-G + diphosphate.”
- database_cross_reference “MetaCyc:RXN-18273”
- database_cross_reference “GOC:mengo_curators”
obsolete GTP:coenzyme F420 guanyltransferase activity database_cross_reference “MetaCyc:RXN-18273”
obsolete GTP:coenzyme F420 guanyltransferase activity SubClassOf guanylyltransferase activity

Added

obsolete GTP:coenzyme F420 guanyltransferase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete GTP:coenzyme F420 guanyltransferase activity definition “OBSOLETE. Catalysis of the reaction: GTP + factor gamma-F420-2 + H+ = coenzyme F390-G + diphosphate.”
- database_cross_reference “GOC:mengo_curators”
obsolete GTP:coenzyme F420 guanyltransferase activity label “obsolete GTP:coenzyme F420 guanyltransferase activity”
obsolete GTP:coenzyme F420 guanyltransferase activity deprecated true
obsolete GTP:coenzyme F420 guanyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI

obsolete Gene_Ontology `http://purl.obolibrary.org/obo/GO_0003673`

Removed

obsolete Gene_Ontology definition “OBSOLETE. A controlled vocabulary that can be applied to all organisms even as knowledge of gene and protein roles in cells is accumulating and changing. GO provides three structured networks of defined terms to describe gene product attributes.”
- database_cross_reference “GOC:go_curators”

Added

obsolete Gene_Ontology definition “OBSOLETE. A controlled vocabulary that can be applied to all organisms even as knowledge of gene and protein roles in cells is accumulating and changing. GO provides three structured networks of defined terms to describe gene product attributes.”
- database_cross_reference “GOC:curators”

obsolete Golgi-ER transport vesicle `http://purl.obolibrary.org/obo/GO_0005806`

Removed

obsolete Golgi-ER transport vesicle definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete Golgi-ER transport vesicle definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete Golgi-plasma membrane transport vesicle `http://purl.obolibrary.org/obo/GO_0005808`

Removed

obsolete Golgi-plasma membrane transport vesicle definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete Golgi-plasma membrane transport vesicle definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete Golgi-vacuole transport vesicle `http://purl.obolibrary.org/obo/GO_0005809`

Removed

obsolete Golgi-vacuole transport vesicle definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete Golgi-vacuole transport vesicle definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete Gram-negative antibacterial peptide activity `http://purl.obolibrary.org/obo/GO_0008225`

Removed

obsolete Gram-negative antibacterial peptide activity definition “OBSOLETE. Inhibits the growth of, or directly kills, Gram-negative bacterial cells.”
- database_cross_reference “GOC:go_curators”

Added

obsolete Gram-negative antibacterial peptide activity definition “OBSOLETE. Inhibits the growth of, or directly kills, Gram-negative bacterial cells.”
- database_cross_reference “GOC:curators”

obsolete Gram-positive antibacterial peptide activity `http://purl.obolibrary.org/obo/GO_0008224`

Removed

obsolete Gram-positive antibacterial peptide activity definition “OBSOLETE. Inhibits the growth of, or directly kills, Gram-positive bacterial cells.”
- database_cross_reference “GOC:go_curators”

Added

obsolete Gram-positive antibacterial peptide activity definition “OBSOLETE. Inhibits the growth of, or directly kills, Gram-positive bacterial cells.”
- database_cross_reference “GOC:curators”

obsolete HA1 clathrin adaptor `http://purl.obolibrary.org/obo/GO_0005907`

Removed

obsolete HA1 clathrin adaptor definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete HA1 clathrin adaptor definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete HA2 clathrin adaptor `http://purl.obolibrary.org/obo/GO_0005908`

Removed

obsolete HA2 clathrin adaptor definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete HA2 clathrin adaptor definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete L-alanine biosynthetic process from pyruvate `http://purl.obolibrary.org/obo/GO_0019272`

Removed

obsolete L-alanine biosynthetic process from pyruvate database_cross_reference “MetaCyc:ALANINE-SYN2-PWY”
obsolete L-alanine biosynthetic process from pyruvate exactMatch ALANINE-SYN2-PWY
obsolete L-alanine biosynthetic process from pyruvate label “L-alanine biosynthetic process from pyruvate”
obsolete L-alanine biosynthetic process from pyruvate definition “The chemical reactions and pathways resulting in the formation of alanine from other compounds, including pyruvate.”
- database_cross_reference “MetaCyc:ALANINE-SYN2-PWY”
- database_cross_reference “GOC:go_curators”
obsolete L-alanine biosynthetic process from pyruvate SubClassOf L-alanine biosynthetic process
obsolete L-alanine biosynthetic process from pyruvate SubClassOf pyruvate metabolic process

Added

obsolete L-alanine biosynthetic process from pyruvate definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of alanine from other compounds, including pyruvate.”
- database_cross_reference “GOC:curators”
obsolete L-alanine biosynthetic process from pyruvate label “obsolete L-alanine biosynthetic process from pyruvate”
obsolete L-alanine biosynthetic process from pyruvate term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
obsolete L-alanine biosynthetic process from pyruvate term replaced by L-alanine biosynthetic process
obsolete L-alanine biosynthetic process from pyruvate comment “The reason for obsoletion is that this term represents a GO-CAM model.”
obsolete L-alanine biosynthetic process from pyruvate deprecated true

obsolete L-alanine biosynthetic process via ornithine `http://purl.obolibrary.org/obo/GO_0019273`

Removed

obsolete L-alanine biosynthetic process via ornithine definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of L-alanine, via the intermediate ornithine.”
- database_cross_reference “GOC:go_curators”

Added

obsolete L-alanine biosynthetic process via ornithine definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of L-alanine, via the intermediate ornithine.”
- database_cross_reference “GOC:curators”

obsolete L-alanine catabolic process, by transamination `http://purl.obolibrary.org/obo/GO_0019481`

Removed

obsolete L-alanine catabolic process, by transamination definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-alanine by transamination.”
- database_cross_reference “GOC:go_curators”

Added

obsolete L-alanine catabolic process, by transamination definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-alanine by transamination.”
- database_cross_reference “GOC:curators”

obsolete L-alanine metabolic process `http://purl.obolibrary.org/obo/GO_0042851`

Removed

obsolete L-alanine metabolic process definition “The chemical reactions and pathways involving L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:jsg”
obsolete L-alanine metabolic process label “L-alanine metabolic process”
obsolete L-alanine metabolic process SubClassOf proteinogenic amino acid metabolic process
obsolete L-alanine metabolic process SubClassOf obsolete alanine metabolic process
obsolete L-alanine metabolic process SubClassOf L-amino acid metabolic process

Added

obsolete L-alanine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI
obsolete L-alanine metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
obsolete L-alanine metabolic process deprecated true
obsolete L-alanine metabolic process database_cross_reference “Reactome:R-HSA-8964540”
- label “Alanine metabolism”
obsolete L-alanine metabolic process consider L-alanine catabolic process
obsolete L-alanine metabolic process label “obsolete L-alanine metabolic process”
obsolete L-alanine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:jsg”
obsolete L-alanine metabolic process consider L-alanine biosynthetic process

obsolete L-arginine biosynthetic process via N-acetyl-L-citrulline `http://purl.obolibrary.org/obo/GO_0170067`

Removed

obsolete L-arginine biosynthetic process via N-acetyl-L-citrulline database_cross_reference “MetaCyc:PWY-5154”
obsolete L-arginine biosynthetic process via N-acetyl-L-citrulline exactMatch PWY-5154
obsolete L-arginine biosynthetic process via N-acetyl-L-citrulline definition “The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound N-acetyl-L-citrulline.”
- database_cross_reference “PMID:16585758”
obsolete L-arginine biosynthetic process via N-acetyl-L-citrulline label “L-arginine biosynthetic process via N-acetyl-L-citrulline”
obsolete L-arginine biosynthetic process via N-acetyl-L-citrulline SubClassOf L-arginine biosynthetic process

Added

obsolete L-arginine biosynthetic process via N-acetyl-L-citrulline term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
obsolete L-arginine biosynthetic process via N-acetyl-L-citrulline term replaced by L-arginine biosynthetic process
obsolete L-arginine biosynthetic process via N-acetyl-L-citrulline deprecated true
obsolete L-arginine biosynthetic process via N-acetyl-L-citrulline label “obsolete L-arginine biosynthetic process via N-acetyl-L-citrulline”
obsolete L-arginine biosynthetic process via N-acetyl-L-citrulline definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound N-acetyl-L-citrulline.”
- database_cross_reference “PMID:16585758”
obsolete L-arginine biosynthetic process via N-acetyl-L-citrulline comment “The reason for obsoletion is that this term represents a GO-CAM model.”

obsolete L-arginine biosynthetic process via ornithine `http://purl.obolibrary.org/obo/GO_0042450`

Removed

obsolete L-arginine biosynthetic process via ornithine label “L-arginine biosynthetic process via ornithine”
obsolete L-arginine biosynthetic process via ornithine definition “The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine.”
- database_cross_reference “GOC:jl”
obsolete L-arginine biosynthetic process via ornithine SubClassOf L-arginine biosynthetic process

Added

obsolete L-arginine biosynthetic process via ornithine term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
obsolete L-arginine biosynthetic process via ornithine comment “The reason for obsoletion is that this term represents a GO-CAM model.”
obsolete L-arginine biosynthetic process via ornithine term replaced by L-arginine biosynthetic process
obsolete L-arginine biosynthetic process via ornithine deprecated true
obsolete L-arginine biosynthetic process via ornithine definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine.”
- database_cross_reference “GOC:jl”
obsolete L-arginine biosynthetic process via ornithine label “obsolete L-arginine biosynthetic process via ornithine”

obsolete L-arginine catabolic process to L-glutamate `http://purl.obolibrary.org/obo/GO_0019544`

Removed

obsolete L-arginine catabolic process to L-glutamate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-arginine into other compounds, including L-glutamate.”
- database_cross_reference “GOC:go_curators”

Added

obsolete L-arginine catabolic process to L-glutamate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-arginine into other compounds, including L-glutamate.”
- database_cross_reference “GOC:curators”

obsolete L-arginine catabolic process to L-proline `http://purl.obolibrary.org/obo/GO_0019493`

Removed

obsolete L-arginine catabolic process to L-proline definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-arginine into other compounds, including L-proline.”
- database_cross_reference “GOC:go_curators”

Added

obsolete L-arginine catabolic process to L-proline definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-arginine into other compounds, including L-proline.”
- database_cross_reference “GOC:curators”

obsolete L-arginine catabolic process to succinate `http://purl.obolibrary.org/obo/GO_0019545`

Removed

obsolete L-arginine catabolic process to succinate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-arginine into other compounds, including succinate.”
- database_cross_reference “GOC:go_curators”

Added

obsolete L-arginine catabolic process to succinate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-arginine into other compounds, including succinate.”
- database_cross_reference “GOC:curators”

obsolete L-asparagine biosynthetic process from L-cysteine `http://purl.obolibrary.org/obo/GO_0019267`

Removed

obsolete L-asparagine biosynthetic process from L-cysteine label “L-asparagine biosynthetic process from L-cysteine”
obsolete L-asparagine biosynthetic process from L-cysteine database_cross_reference “MetaCyc:ASPSYNII-PWY”
obsolete L-asparagine biosynthetic process from L-cysteine definition “The chemical reactions and pathways resulting in the formation of L-asparagine from other compounds, including L-cysteine.”
- database_cross_reference “GOC:go_curators”
obsolete L-asparagine biosynthetic process from L-cysteine SubClassOf L-asparagine biosynthetic process
obsolete L-asparagine biosynthetic process from L-cysteine SubClassOf obsolete L-cysteine metabolic process

Added

obsolete L-asparagine biosynthetic process from L-cysteine label “obsolete L-asparagine biosynthetic process from L-cysteine”
obsolete L-asparagine biosynthetic process from L-cysteine definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of L-asparagine from other compounds, including L-cysteine.”
- database_cross_reference “GOC:curators”
obsolete L-asparagine biosynthetic process from L-cysteine deprecated true
obsolete L-asparagine biosynthetic process from L-cysteine comment “This term was obsoleted because it is too specific and is outside the scope of GO.”
obsolete L-asparagine biosynthetic process from L-cysteine term replaced by L-asparagine biosynthetic process

obsolete L-asparagine biosynthetic process from oxaloacetate `http://purl.obolibrary.org/obo/GO_0019266`

Removed

obsolete L-asparagine biosynthetic process from oxaloacetate database_cross_reference “MetaCyc:ASPARAGINE-BIOSYNTHESIS”
obsolete L-asparagine biosynthetic process from oxaloacetate label “L-asparagine biosynthetic process from oxaloacetate”
obsolete L-asparagine biosynthetic process from oxaloacetate definition “The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including oxaloacetate.”
- database_cross_reference “GOC:go_curators”
obsolete L-asparagine biosynthetic process from oxaloacetate SubClassOf dicarboxylic acid catabolic process
obsolete L-asparagine biosynthetic process from oxaloacetate SubClassOf L-asparagine biosynthetic process
obsolete L-asparagine biosynthetic process from oxaloacetate SubClassOf oxaloacetate metabolic process

Added

obsolete L-asparagine biosynthetic process from oxaloacetate label “obsolete L-asparagine biosynthetic process from oxaloacetate”
obsolete L-asparagine biosynthetic process from oxaloacetate term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
obsolete L-asparagine biosynthetic process from oxaloacetate deprecated true
obsolete L-asparagine biosynthetic process from oxaloacetate definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including oxaloacetate.”
- database_cross_reference “GOC:curators”
obsolete L-asparagine biosynthetic process from oxaloacetate comment “This term was obsoleted because it represents a specific pathway and is out of scope for GO.”
obsolete L-asparagine biosynthetic process from oxaloacetate term replaced by L-asparagine biosynthetic process

obsolete L-asparagine metabolic process `http://purl.obolibrary.org/obo/GO_0070982`

Removed

obsolete L-asparagine metabolic process definition “The chemical reactions and pathways involving L-asparagine, (2S)-2-amino-3-carbamoylpropanoic acid.”
- database_cross_reference “GOC:mah”
obsolete L-asparagine metabolic process label “L-asparagine metabolic process”
obsolete L-asparagine metabolic process SubClassOf asparagine metabolic process
obsolete L-asparagine metabolic process SubClassOf L-amino acid metabolic process
obsolete L-asparagine metabolic process SubClassOf proteinogenic amino acid metabolic process

Added

obsolete L-asparagine metabolic process deprecated true
obsolete L-asparagine metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
obsolete L-asparagine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI
obsolete L-asparagine metabolic process label “obsolete L-asparagine metabolic process”
obsolete L-asparagine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving L-asparagine, (2S)-2-amino-3-carbamoylpropanoic acid.”
- database_cross_reference “GOC:mah”

obsolete L-cysteine biosynthetic process from L-serine `http://purl.obolibrary.org/obo/GO_0006535`

Removed

obsolete L-cysteine biosynthetic process from L-serine database_cross_reference “MetaCyc:CYSTSYN-PWY”
obsolete L-cysteine biosynthetic process from L-serine label “L-cysteine biosynthetic process from L-serine”
obsolete L-cysteine biosynthetic process from L-serine exactMatch CYSTSYN-PWY
obsolete L-cysteine biosynthetic process from L-serine definition “The chemical reactions and pathways resulting in the formation of cysteine from L- serine.”
- database_cross_reference “MetaCyc:CYSTSYN-PWY”
obsolete L-cysteine biosynthetic process from L-serine SubClassOf L-serine metabolic process
obsolete L-cysteine biosynthetic process from L-serine SubClassOf L-cysteine biosynthetic process

Added

obsolete L-cysteine biosynthetic process from L-serine label “obsolete L-cysteine biosynthetic process from L-serine”
obsolete L-cysteine biosynthetic process from L-serine term tracker item “https://github.com/geneontology/go-ontology/issues/31281”^^anyURI
obsolete L-cysteine biosynthetic process from L-serine definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of cysteine from L- serine.”
- database_cross_reference “GOC:curators”
obsolete L-cysteine biosynthetic process from L-serine term replaced by L-cysteine biosynthetic process
obsolete L-cysteine biosynthetic process from L-serine deprecated true
obsolete L-cysteine biosynthetic process from L-serine comment “This term was obsoleted because it is too specific and is outside the scope of GO.”

obsolete L-cysteine biosynthetic process via L-cystathionine `http://purl.obolibrary.org/obo/GO_0019343`

Removed

obsolete L-cysteine biosynthetic process via L-cystathionine exactMatch HOMOCYSDEGR-PWY
obsolete L-cysteine biosynthetic process via L-cystathionine label “L-cysteine biosynthetic process via L-cystathionine”
obsolete L-cysteine biosynthetic process via L-cystathionine database_cross_reference “MetaCyc:HOMOCYSDEGR-PWY”
obsolete L-cysteine biosynthetic process via L-cystathionine definition “The chemical reactions and pathways resulting in the formation of L-cysteine, via the intermediate L-cystathionine.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “MetaCyc:HOMOCYSDEGR-PWY”
obsolete L-cysteine biosynthetic process via L-cystathionine SubClassOf L-cysteine biosynthetic process

Added

obsolete L-cysteine biosynthetic process via L-cystathionine comment “This term was obsoleted because it is too specific and is outside the scope of GO.”
obsolete L-cysteine biosynthetic process via L-cystathionine label “obsolete L-cysteine biosynthetic process via L-cystathionine”
obsolete L-cysteine biosynthetic process via L-cystathionine definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of L-cysteine, via the intermediate L-cystathionine.”
- database_cross_reference “GOC:curators”
obsolete L-cysteine biosynthetic process via L-cystathionine deprecated true
obsolete L-cysteine biosynthetic process via L-cystathionine term replaced by L-cysteine biosynthetic process

obsolete L-cysteine biosynthetic process via S-sulfo-L-cysteine `http://purl.obolibrary.org/obo/GO_0019345`

Removed

obsolete L-cysteine biosynthetic process via S-sulfo-L-cysteine exactMatch PWY-7289
obsolete L-cysteine biosynthetic process via S-sulfo-L-cysteine label “L-cysteine biosynthetic process via S-sulfo-L-cysteine”
obsolete L-cysteine biosynthetic process via S-sulfo-L-cysteine definition “The chemical reactions and pathways resulting in the formation of L-cysteine, via the intermediate S-sulfo-L-cysteine.”
- database_cross_reference “MetaCyc:PWY-7289”
obsolete L-cysteine biosynthetic process via S-sulfo-L-cysteine database_cross_reference “MetaCyc:PWY-7289”
obsolete L-cysteine biosynthetic process via S-sulfo-L-cysteine SubClassOf L-cysteine biosynthetic process

Added

obsolete L-cysteine biosynthetic process via S-sulfo-L-cysteine comment “This term was obsoleted because it is too specific and is outside the scope of GO.”
obsolete L-cysteine biosynthetic process via S-sulfo-L-cysteine term replaced by L-cysteine biosynthetic process
obsolete L-cysteine biosynthetic process via S-sulfo-L-cysteine deprecated true
obsolete L-cysteine biosynthetic process via S-sulfo-L-cysteine label “obsolete L-cysteine biosynthetic process via S-sulfo-L-cysteine”
obsolete L-cysteine biosynthetic process via S-sulfo-L-cysteine definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of L-cysteine, via the intermediate S-sulfo-L-cysteine.”
- database_cross_reference “GOC:curators”

obsolete L-cysteine catabolic process to hypotaurine `http://purl.obolibrary.org/obo/GO_0019449`

Removed

obsolete L-cysteine catabolic process to hypotaurine definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including hypotaurine.”
- database_cross_reference “GOC:go_curators”

Added

obsolete L-cysteine catabolic process to hypotaurine definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including hypotaurine.”
- database_cross_reference “GOC:curators”

obsolete L-cysteine catabolic process to pyruvate `http://purl.obolibrary.org/obo/GO_0019450`

Removed

obsolete L-cysteine catabolic process to pyruvate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including pyruvate.”
- database_cross_reference “GOC:go_curators”

Added

obsolete L-cysteine catabolic process to pyruvate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including pyruvate.”
- database_cross_reference “GOC:curators”

obsolete L-cysteine catabolic process to pyruvate, using cysteine dioxygenase `http://purl.obolibrary.org/obo/GO_0019451`

Removed

obsolete L-cysteine catabolic process to pyruvate, using cysteine dioxygenase label “L-cysteine catabolic process to pyruvate, using cysteine dioxygenase”
obsolete L-cysteine catabolic process to pyruvate, using cysteine dioxygenase definition “The chemical reactions and pathways resulting in the breakdown into pyruvate of L-cystine, catalyzed by the enzyme cysteine dioxygenase (EC:1.13.11.20).”
- database_cross_reference “GOC:jl”
obsolete L-cysteine catabolic process to pyruvate, using cysteine dioxygenase SubClassOf has part some cysteine dioxygenase activity
obsolete L-cysteine catabolic process to pyruvate, using cysteine dioxygenase SubClassOf L-cysteine catabolic process
obsolete L-cysteine catabolic process to pyruvate, using cysteine dioxygenase SubClassOf pyruvate metabolic process

Added

obsolete L-cysteine catabolic process to pyruvate, using cysteine dioxygenase deprecated true
obsolete L-cysteine catabolic process to pyruvate, using cysteine dioxygenase comment “This term was obsoleted because it represents a specific instance of a pathway that should be captured as a GO-CAM model.”
obsolete L-cysteine catabolic process to pyruvate, using cysteine dioxygenase definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown into pyruvate of L-cystine, catalyzed by the enzyme cysteine dioxygenase (EC:1.13.11.20).”
- database_cross_reference “GOC:jl”
obsolete L-cysteine catabolic process to pyruvate, using cysteine dioxygenase term tracker item “https://github.com/geneontology/go-ontology/issues/30202”^^anyURI
obsolete L-cysteine catabolic process to pyruvate, using cysteine dioxygenase label “obsolete L-cysteine catabolic process to pyruvate, using cysteine dioxygenase”
obsolete L-cysteine catabolic process to pyruvate, using cysteine dioxygenase term replaced by L-cysteine catabolic process

obsolete L-cysteine catabolic process via cystine `http://purl.obolibrary.org/obo/GO_0019453`

Removed

obsolete L-cysteine catabolic process via cystine definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-cysteine, via the intermediate cystine.”
- database_cross_reference “GOC:go_curators”

Added

obsolete L-cysteine catabolic process via cystine definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-cysteine, via the intermediate cystine.”
- database_cross_reference “GOC:curators”

obsolete L-cysteine catabolic process via cystine, using cysteine transaminase `http://purl.obolibrary.org/obo/GO_0019456`

Removed

obsolete L-cysteine catabolic process via cystine, using cysteine transaminase definition “The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cysteine transaminase.”
- database_cross_reference “GOC:jl”
obsolete L-cysteine catabolic process via cystine, using cysteine transaminase label “L-cysteine catabolic process via cystine, using cysteine transaminase”
obsolete L-cysteine catabolic process via cystine, using cysteine transaminase SubClassOf L-cysteine catabolic process
obsolete L-cysteine catabolic process via cystine, using cysteine transaminase SubClassOf has part some L-cysteine:2-oxoglutarate transaminase activity

Added

obsolete L-cysteine catabolic process via cystine, using cysteine transaminase term replaced by L-cysteine catabolic process
obsolete L-cysteine catabolic process via cystine, using cysteine transaminase comment “This term was obsoleted because it represents a specific instance of a pathway that should be captured as a GO-CAM model.”
obsolete L-cysteine catabolic process via cystine, using cysteine transaminase definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cysteine transaminase.”
- database_cross_reference “GOC:jl”
obsolete L-cysteine catabolic process via cystine, using cysteine transaminase deprecated true
obsolete L-cysteine catabolic process via cystine, using cysteine transaminase label “obsolete L-cysteine catabolic process via cystine, using cysteine transaminase”
obsolete L-cysteine catabolic process via cystine, using cysteine transaminase term tracker item “https://github.com/geneontology/go-ontology/issues/30202”^^anyURI

obsolete L-cysteine catabolic process via cystine, using cystine reductase `http://purl.obolibrary.org/obo/GO_0019455`

Removed

obsolete L-cysteine catabolic process via cystine, using cystine reductase definition “The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cystine reductase.”
- database_cross_reference “GOC:jl”
obsolete L-cysteine catabolic process via cystine, using cystine reductase label “L-cysteine catabolic process via cystine, using cystine reductase”
obsolete L-cysteine catabolic process via cystine, using cystine reductase SubClassOf has part some L-cystine reductase (NADH) activity
obsolete L-cysteine catabolic process via cystine, using cystine reductase SubClassOf L-cysteine catabolic process

Added

obsolete L-cysteine catabolic process via cystine, using cystine reductase term tracker item “https://github.com/geneontology/go-ontology/issues/30202”^^anyURI
obsolete L-cysteine catabolic process via cystine, using cystine reductase comment “This term was obsoleted because it represents a specific instance of a pathway that should be captured as a GO-CAM model.”
obsolete L-cysteine catabolic process via cystine, using cystine reductase term replaced by L-cysteine catabolic process
obsolete L-cysteine catabolic process via cystine, using cystine reductase label “obsolete L-cysteine catabolic process via cystine, using cystine reductase”
obsolete L-cysteine catabolic process via cystine, using cystine reductase definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cystine reductase.”
- database_cross_reference “GOC:jl”
obsolete L-cysteine catabolic process via cystine, using cystine reductase deprecated true

obsolete L-cysteine catabolic process via cystine, using glutathione-cystine transhydrogenase `http://purl.obolibrary.org/obo/GO_0019454`

Removed

obsolete L-cysteine catabolic process via cystine, using glutathione-cystine transhydrogenase definition “The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme glutathione-cystine transhydrogenase.”
- database_cross_reference “GOC:jl”
obsolete L-cysteine catabolic process via cystine, using glutathione-cystine transhydrogenase label “L-cysteine catabolic process via cystine, using glutathione-cystine transhydrogenase”
obsolete L-cysteine catabolic process via cystine, using glutathione-cystine transhydrogenase SubClassOf has part some glutathione-cystine transhydrogenase activity
obsolete L-cysteine catabolic process via cystine, using glutathione-cystine transhydrogenase SubClassOf L-cysteine catabolic process

Added

obsolete L-cysteine catabolic process via cystine, using glutathione-cystine transhydrogenase deprecated true
obsolete L-cysteine catabolic process via cystine, using glutathione-cystine transhydrogenase definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme glutathione-cystine transhydrogenase.”
- database_cross_reference “GOC:jl”
obsolete L-cysteine catabolic process via cystine, using glutathione-cystine transhydrogenase label “obsolete L-cysteine catabolic process via cystine, using glutathione-cystine transhydrogenase”
obsolete L-cysteine catabolic process via cystine, using glutathione-cystine transhydrogenase comment “This term was obsoleted because it represents a specific instance of a pathway that should be captured as a GO-CAM model.”
obsolete L-cysteine catabolic process via cystine, using glutathione-cystine transhydrogenase term tracker item “https://github.com/geneontology/go-ontology/issues/30202”^^anyURI
obsolete L-cysteine catabolic process via cystine, using glutathione-cystine transhydrogenase term replaced by L-cysteine catabolic process

obsolete L-cysteine metabolic process `http://purl.obolibrary.org/obo/GO_0046439`

Removed

obsolete L-cysteine metabolic process definition “The chemical reactions and pathways involving L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:jsg”
- database_cross_reference “GOC:ai”
obsolete L-cysteine metabolic process label “L-cysteine metabolic process”
obsolete L-cysteine metabolic process SubClassOf proteinogenic amino acid metabolic process
obsolete L-cysteine metabolic process SubClassOf obsolete cysteine metabolic process
obsolete L-cysteine metabolic process SubClassOf L-amino acid metabolic process

Added

obsolete L-cysteine metabolic process consider L-cysteine catabolic process
obsolete L-cysteine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:jsg”
- database_cross_reference “GOC:ai”
obsolete L-cysteine metabolic process label “obsolete L-cysteine metabolic process”
obsolete L-cysteine metabolic process consider L-cysteine biosynthetic process
obsolete L-cysteine metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
obsolete L-cysteine metabolic process deprecated true
obsolete L-cysteine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI

obsolete L-erythro-3-methylmalyl-CoA dehydratase activity `http://purl.obolibrary.org/obo/GO_0043960`

Removed

obsolete L-erythro-3-methylmalyl-CoA dehydratase activity definition “Catalysis of the reaction: L-erythro-3-methylmalyl-CoA = mesaconyl-CoA + H2O.”
- database_cross_reference “GOC:jl”
obsolete L-erythro-3-methylmalyl-CoA dehydratase activity label “L-erythro-3-methylmalyl-CoA dehydratase activity”
obsolete L-erythro-3-methylmalyl-CoA dehydratase activity SubClassOf hydro-lyase activity

Added

obsolete L-erythro-3-methylmalyl-CoA dehydratase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete L-erythro-3-methylmalyl-CoA dehydratase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete L-erythro-3-methylmalyl-CoA dehydratase activity label “obsolete L-erythro-3-methylmalyl-CoA dehydratase activity”
obsolete L-erythro-3-methylmalyl-CoA dehydratase activity deprecated true
obsolete L-erythro-3-methylmalyl-CoA dehydratase activity definition “OBSOLETE. Catalysis of the reaction: L-erythro-3-methylmalyl-CoA = mesaconyl-CoA + H2O.”
- database_cross_reference “GOC:jl”

obsolete L-glutamate catabolic process to aspartate `http://purl.obolibrary.org/obo/GO_0019550`

Removed

obsolete L-glutamate catabolic process to aspartate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-glutamate into other compounds, including aspartate.”
- database_cross_reference “GOC:go_curators”

Added

obsolete L-glutamate catabolic process to aspartate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-glutamate into other compounds, including aspartate.”
- database_cross_reference “GOC:curators”

obsolete L-glutamate catabolic process to ornithine `http://purl.obolibrary.org/obo/GO_0019555`

Removed

obsolete L-glutamate catabolic process to ornithine definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-glutamate into other compounds, including ornithine.”
- database_cross_reference “GOC:go_curators”

Added

obsolete L-glutamate catabolic process to ornithine definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-glutamate into other compounds, including ornithine.”
- database_cross_reference “GOC:curators”

obsolete L-glutamate fermentation to propionate `http://purl.obolibrary.org/obo/GO_0033509`

Removed

obsolete L-glutamate fermentation to propionate label “L-glutamate fermentation to propionate”
obsolete L-glutamate fermentation to propionate database_cross_reference “MetaCyc:PWY-5088”
obsolete L-glutamate fermentation to propionate definition “The chemical reactions and pathways resulting in the breakdown of L-glutamate into other compounds, including propionate.”
- database_cross_reference “GOC:mah”
- database_cross_reference “MetaCyc:PWY-5088”
obsolete L-glutamate fermentation to propionate SubClassOf propionate metabolic process
obsolete L-glutamate fermentation to propionate SubClassOf amino acid fermentation
obsolete L-glutamate fermentation to propionate SubClassOf L-glutamate catabolic process

Added

obsolete L-glutamate fermentation to propionate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-glutamate into other compounds, including propionate.”
- database_cross_reference “GOC:mah”
obsolete L-glutamate fermentation to propionate term replaced by L-glutamate fermentation
obsolete L-glutamate fermentation to propionate label “obsolete L-glutamate fermentation to propionate”
obsolete L-glutamate fermentation to propionate deprecated true
obsolete L-glutamate fermentation to propionate comment “This term was obsoleted because it represents a specific instance of a pathway that should be captured as a GO-CAM model.”

obsolete L-glutamate fermentation via 2-hydroxyglutarate `http://purl.obolibrary.org/obo/GO_0019552`

Removed

obsolete L-glutamate fermentation via 2-hydroxyglutarate narrowMatch P162-PWY
obsolete L-glutamate fermentation via 2-hydroxyglutarate database_cross_reference “MetaCyc:P162-PWY”
obsolete L-glutamate fermentation via 2-hydroxyglutarate label “L-glutamate fermentation via 2-hydroxyglutarate”
obsolete L-glutamate fermentation via 2-hydroxyglutarate definition “The anaerobic chemical reactions and pathways resulting in the breakdown of L-glutamate, via the intermediate 2-hydroxyglutarate, yielding acetyl-CoA and butanoate. Acetyl-CoA can be further converted into acetate, releasing one ATP molecule.”
- database_cross_reference “PMID:17166837”
obsolete L-glutamate fermentation via 2-hydroxyglutarate SubClassOf amino acid fermentation
obsolete L-glutamate fermentation via 2-hydroxyglutarate SubClassOf L-glutamate catabolic process

Added

obsolete L-glutamate fermentation via 2-hydroxyglutarate comment “This term was obsoleted because it represents a specific instance of a pathway that should be captured as a GO-CAM model.”
obsolete L-glutamate fermentation via 2-hydroxyglutarate term replaced by L-glutamate fermentation
obsolete L-glutamate fermentation via 2-hydroxyglutarate label “obsolete L-glutamate fermentation via 2-hydroxyglutarate”
obsolete L-glutamate fermentation via 2-hydroxyglutarate deprecated true
obsolete L-glutamate fermentation via 2-hydroxyglutarate definition “OBSOLETE. The anaerobic chemical reactions and pathways resulting in the breakdown of L-glutamate, via the intermediate 2-hydroxyglutarate, yielding acetyl-CoA and butanoate. Acetyl-CoA can be further converted into acetate, releasing one ATP molecule.”
- database_cross_reference “PMID:17166837”

obsolete L-glutamate fermentation via L-citramalate `http://purl.obolibrary.org/obo/GO_0019553`

Removed

obsolete L-glutamate fermentation via L-citramalate database_cross_reference “MetaCyc:GLUDEG-II-PWY”
obsolete L-glutamate fermentation via L-citramalate definition “The chemical reactions and pathways resulting in the breakdown of L-glutamate, via the intermediate L-citramalate.”
- database_cross_reference “GOC:go_curators”
obsolete L-glutamate fermentation via L-citramalate label “L-glutamate fermentation via L-citramalate”
obsolete L-glutamate fermentation via L-citramalate SubClassOf L-glutamate catabolic process
obsolete L-glutamate fermentation via L-citramalate SubClassOf amino acid fermentation

Added

obsolete L-glutamate fermentation via L-citramalate term replaced by L-glutamate fermentation
obsolete L-glutamate fermentation via L-citramalate label “obsolete L-glutamate fermentation via L-citramalate”
obsolete L-glutamate fermentation via L-citramalate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-glutamate, via the intermediate L-citramalate.”
- database_cross_reference “GOC:curators”
obsolete L-glutamate fermentation via L-citramalate deprecated true
obsolete L-glutamate fermentation via L-citramalate comment “This term was obsoleted because it represents a specific instance of a pathway that should be captured as a GO-CAM model.”

obsolete L-glutamine transaminase activity `http://purl.obolibrary.org/obo/GO_0070548`

Removed

obsolete L-glutamine transaminase activity definition “Catalysis of the transfer of an amino group from L-glutamine to an acceptor, usually a 2-oxo acid.”
- database_cross_reference “GOC:mah”
obsolete L-glutamine transaminase activity label “L-glutamine aminotransferase activity”
obsolete L-glutamine transaminase activity SubClassOf transaminase activity

Added

obsolete L-glutamine transaminase activity comment “This term was obsoleted because it is too general. Consider other glutamine transaminase activity terms.”
obsolete L-glutamine transaminase activity consider L-glutamine:pyruvate transaminase activity
obsolete L-glutamine transaminase activity definition “OBSOLETE. Catalysis of the transfer of an amino group from L-glutamine to an acceptor, usually a 2-oxo acid.”
- database_cross_reference “GOC:mah”
obsolete L-glutamine transaminase activity label “obsolete L-glutamine transaminase activity”
obsolete L-glutamine transaminase activity has_exact_synonym “L-glutamine aminotransferase activity”
obsolete L-glutamine transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
obsolete L-glutamine transaminase activity deprecated true

obsolete L-histidine catabolic process to 2-oxoglutarate `http://purl.obolibrary.org/obo/GO_0019558`

Removed

obsolete L-histidine catabolic process to 2-oxoglutarate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including 2-oxoglutarate.”
- database_cross_reference “GOC:go_curators”

Added

obsolete L-histidine catabolic process to 2-oxoglutarate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including 2-oxoglutarate.”
- database_cross_reference “GOC:curators”

obsolete L-histidine catabolic process to glutamate and formamide `http://purl.obolibrary.org/obo/GO_0019556`

Removed

obsolete L-histidine catabolic process to glutamate and formamide definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including glutamate and formamide.”
- database_cross_reference “GOC:go_curators”

Added

obsolete L-histidine catabolic process to glutamate and formamide definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including glutamate and formamide.”
- database_cross_reference “GOC:curators”

obsolete L-histidine catabolic process to glutamate and formate `http://purl.obolibrary.org/obo/GO_0019557`

Removed

obsolete L-histidine catabolic process to glutamate and formate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including glutamate and formate.”
- database_cross_reference “GOC:go_curators”

Added

obsolete L-histidine catabolic process to glutamate and formate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including glutamate and formate.”
- database_cross_reference “GOC:curators”

obsolete L-histidine catabolic process to hydantoin-5-propionate `http://purl.obolibrary.org/obo/GO_0019560`

Removed

obsolete L-histidine catabolic process to hydantoin-5-propionate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including hydantoin-5-propionate.”
- database_cross_reference “GOC:go_curators”

Added

obsolete L-histidine catabolic process to hydantoin-5-propionate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including hydantoin-5-propionate.”
- database_cross_reference “GOC:curators”

obsolete L-histidine catabolic process to imidazol-5-yl-lactate `http://purl.obolibrary.org/obo/GO_0019559`

Removed

obsolete L-histidine catabolic process to imidazol-5-yl-lactate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including imidazol-5-yl-lactate.”
- database_cross_reference “GOC:go_curators”

Added

obsolete L-histidine catabolic process to imidazol-5-yl-lactate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including imidazol-5-yl-lactate.”
- database_cross_reference “GOC:curators”

obsolete L-histidine metabolic process `http://purl.obolibrary.org/obo/GO_0006547`

Removed

obsolete L-histidine metabolic process definition “The chemical reactions and pathways involving L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.”
- database_cross_reference “GOC:go_curators”
obsolete L-histidine metabolic process label “L-histidine metabolic process”
obsolete L-histidine metabolic process SubClassOf imidazole-containing compound metabolic process
obsolete L-histidine metabolic process SubClassOf L-amino acid metabolic process
obsolete L-histidine metabolic process SubClassOf aromatic amino acid metabolic process
obsolete L-histidine metabolic process SubClassOf proteinogenic amino acid metabolic process

Added

obsolete L-histidine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI
obsolete L-histidine metabolic process consider L-histidine biosynthetic process
obsolete L-histidine metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
obsolete L-histidine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.”
- database_cross_reference “GOC:curators”
obsolete L-histidine metabolic process deprecated true
obsolete L-histidine metabolic process label “obsolete L-histidine metabolic process”
obsolete L-histidine metabolic process consider L-histidine catabolic process

obsolete L-homoserine catabolic process `http://purl.obolibrary.org/obo/GO_0009091`

Removed

obsolete L-homoserine catabolic process label “L-homoserine catabolic process”
obsolete L-homoserine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of homoserine, alpha-amino-gamma-hydroxybutyric acid.”
- database_cross_reference “ISBN:0198506732”
obsolete L-homoserine catabolic process SubClassOf L-amino acid catabolic process
obsolete L-homoserine catabolic process SubClassOf L-homoserine metabolic process
obsolete L-homoserine catabolic process SubClassOf non-proteinogenic amino acid catabolic process

Added

obsolete L-homoserine catabolic process label “obsolete L-homoserine catabolic process”
obsolete L-homoserine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of homoserine, alpha-amino-gamma-hydroxybutyric acid.”
- database_cross_reference “ISBN:0198506732”
obsolete L-homoserine catabolic process comment “This term was obsoleted because there is no evidence that a specific pathway for L-homoserine degradation exists.”
obsolete L-homoserine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31361”^^anyURI
obsolete L-homoserine catabolic process deprecated true

obsolete L-kynurenine metabolic process `http://purl.obolibrary.org/obo/GO_0097052`

Removed

obsolete L-kynurenine metabolic process label “L-kynurenine metabolic process”
obsolete L-kynurenine metabolic process definition “The chemical reactions and pathways involving L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine).”
- database_cross_reference “GOC:yaf”
obsolete L-kynurenine metabolic process SubClassOf kynurenine metabolic process
obsolete L-kynurenine metabolic process SubClassOf L-amino acid metabolic process

Added

obsolete L-kynurenine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI
obsolete L-kynurenine metabolic process deprecated true
obsolete L-kynurenine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine).”
- database_cross_reference “GOC:yaf”
obsolete L-kynurenine metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
obsolete L-kynurenine metabolic process label “obsolete L-kynurenine metabolic process”

obsolete L-lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate `http://purl.obolibrary.org/obo/GO_0051976`

Removed

obsolete L-lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate database_cross_reference “MetaCyc:PWY-3081”
obsolete L-lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate definition “The chemical reactions and pathways resulting in the formation of L-lysine via the intermediates alpha-aminoadipic acid and N2-acetyl-alpha-aminoadipate. This pathway of prokaryotic lysine biosynthesis via alpha-aminoadipate was discovered in the hyper-thermophilic Gram-negative eubacterium Thermus thermophilus. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This undergoes acetylation, to form N2-acetyl-alpha-aminoadipate, and is then phosphorylated to give N2-acetyl-alpha-aminoadipyl-delta-phosphate. This is converted to N2-acetyl-alpha-aminoadipate semialdehyde, which is then converted to N2-acetyl-L-lysine. A final deacetylation reaction produces L-lysine.”
- database_cross_reference “MetaCyc:PWY-3081”
obsolete L-lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate label “L-lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate”
obsolete L-lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate SubClassOf obsolete L-lysine biosynthetic process via aminoadipic acid

Added

obsolete L-lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
obsolete L-lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate deprecated true
obsolete L-lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate term replaced by L-lysine biosynthetic process
obsolete L-lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of L-lysine via the intermediates alpha-aminoadipic acid and N2-acetyl-alpha-aminoadipate. This pathway of prokaryotic lysine biosynthesis via alpha-aminoadipate was discovered in the hyper-thermophilic Gram-negative eubacterium Thermus thermophilus. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This undergoes acetylation, to form N2-acetyl-alpha-aminoadipate, and is then phosphorylated to give N2-acetyl-alpha-aminoadipyl-delta-phosphate. This is converted to N2-acetyl-alpha-aminoadipate semialdehyde, which is then converted to N2-acetyl-L-lysine. A final deacetylation reaction produces L-lysine.”
- database_cross_reference “GOC:curators”
obsolete L-lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate label “obsolete L-lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate”
obsolete L-lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate comment “The reason for obsoletion is that this term represents a GO-CAM model.”

obsolete L-lysine biosynthetic process via alpha-aminoadipate and saccharopine `http://purl.obolibrary.org/obo/GO_0051975`

Removed

obsolete L-lysine biosynthetic process via alpha-aminoadipate and saccharopine definition “The chemical reactions and pathways resulting in the formation of L-lysine via the intermediates alpha-aminoadipic acid and saccharopine. This pathway is used by yeast and fungi to synthesize the essential amino acid L-lysine, and pathway intermediates are often incorporated into secondary metabolic processes. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This is then reduced to form alpha-aminoadipate 6-semialdehyde, which is metabolized to saccharopine and finally L-lysine.”
- database_cross_reference “MetaCyc:LYSINE-AMINOAD-PWY”
obsolete L-lysine biosynthetic process via alpha-aminoadipate and saccharopine label “L-lysine biosynthetic process via alpha-aminoadipate and saccharopine”
obsolete L-lysine biosynthetic process via alpha-aminoadipate and saccharopine database_cross_reference “MetaCyc:LYSINE-AMINOAD-PWY”
obsolete L-lysine biosynthetic process via alpha-aminoadipate and saccharopine SubClassOf obsolete L-lysine biosynthetic process via aminoadipic acid

Added

obsolete L-lysine biosynthetic process via alpha-aminoadipate and saccharopine deprecated true
obsolete L-lysine biosynthetic process via alpha-aminoadipate and saccharopine term replaced by L-lysine biosynthetic process
obsolete L-lysine biosynthetic process via alpha-aminoadipate and saccharopine definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of L-lysine via the intermediates alpha-aminoadipic acid and saccharopine. This pathway is used by yeast and fungi to synthesize the essential amino acid L-lysine, and pathway intermediates are often incorporated into secondary metabolic processes. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This is then reduced to form alpha-aminoadipate 6-semialdehyde, which is metabolized to saccharopine and finally L-lysine.”
- database_cross_reference “GOC:curators”
obsolete L-lysine biosynthetic process via alpha-aminoadipate and saccharopine label “obsolete L-lysine biosynthetic process via alpha-aminoadipate and saccharopine”
obsolete L-lysine biosynthetic process via alpha-aminoadipate and saccharopine comment “The reason for obsoletion is that this term represents a GO-CAM model.”
obsolete L-lysine biosynthetic process via alpha-aminoadipate and saccharopine term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI

obsolete L-lysine biosynthetic process via aminoadipic acid `http://purl.obolibrary.org/obo/GO_0019878`

Removed

obsolete L-lysine biosynthetic process via aminoadipic acid label “L-lysine biosynthetic process via aminoadipic acid”
obsolete L-lysine biosynthetic process via aminoadipic acid definition “The chemical reactions and pathways resulting in the formation of L-lysine by the aminoadipic pathway.”
- database_cross_reference “GOC:go_curators”
obsolete L-lysine biosynthetic process via aminoadipic acid SubClassOf L-lysine biosynthetic process

Added

obsolete L-lysine biosynthetic process via aminoadipic acid comment “The reason for obsoletion is that this term represents a GO-CAM model.”
obsolete L-lysine biosynthetic process via aminoadipic acid definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of L-lysine by the aminoadipic pathway.”
- database_cross_reference “GOC:curators”
obsolete L-lysine biosynthetic process via aminoadipic acid label “obsolete L-lysine biosynthetic process via aminoadipic acid”
obsolete L-lysine biosynthetic process via aminoadipic acid term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
obsolete L-lysine biosynthetic process via aminoadipic acid term replaced by L-lysine biosynthetic process
obsolete L-lysine biosynthetic process via aminoadipic acid deprecated true

obsolete L-lysine biosynthetic process via diaminopimelate `http://purl.obolibrary.org/obo/GO_0009089`

Removed

obsolete L-lysine biosynthetic process via diaminopimelate label “L-lysine biosynthetic process via diaminopimelate”
obsolete L-lysine biosynthetic process via diaminopimelate definition “The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate.”
- database_cross_reference “GOC:go_curators”
obsolete L-lysine biosynthetic process via diaminopimelate SubClassOf L-lysine biosynthetic process

Added

obsolete L-lysine biosynthetic process via diaminopimelate term replaced by L-lysine biosynthetic process
obsolete L-lysine biosynthetic process via diaminopimelate definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate.”
- database_cross_reference “GOC:curators”
obsolete L-lysine biosynthetic process via diaminopimelate label “obsolete L-lysine biosynthetic process via diaminopimelate”
obsolete L-lysine biosynthetic process via diaminopimelate comment “The reason for obsoletion is that this term represents a GO-CAM model.”
obsolete L-lysine biosynthetic process via diaminopimelate term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
obsolete L-lysine biosynthetic process via diaminopimelate deprecated true

obsolete L-lysine biosynthetic process via diaminopimelate and L-2-acetamido-6-oxoheptanedioate `http://purl.obolibrary.org/obo/GO_0033360`

Removed

obsolete L-lysine biosynthetic process via diaminopimelate and L-2-acetamido-6-oxoheptanedioate database_cross_reference “MetaCyc:PWY-2941”
obsolete L-lysine biosynthetic process via diaminopimelate and L-2-acetamido-6-oxoheptanedioate label “L-lysine biosynthetic process via diaminopimelate and L-2-acetamido-6-oxoheptanedioate”
obsolete L-lysine biosynthetic process via diaminopimelate and L-2-acetamido-6-oxoheptanedioate definition “The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and L-2-acetamido-6-oxoheptanedioate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps.”
- database_cross_reference “GOC:mah”
- database_cross_reference “MetaCyc:PWY-2941”
obsolete L-lysine biosynthetic process via diaminopimelate and L-2-acetamido-6-oxoheptanedioate SubClassOf obsolete L-lysine biosynthetic process via diaminopimelate

Added

obsolete L-lysine biosynthetic process via diaminopimelate and L-2-acetamido-6-oxoheptanedioate term replaced by L-lysine biosynthetic process
obsolete L-lysine biosynthetic process via diaminopimelate and L-2-acetamido-6-oxoheptanedioate term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
obsolete L-lysine biosynthetic process via diaminopimelate and L-2-acetamido-6-oxoheptanedioate label “obsolete L-lysine biosynthetic process via diaminopimelate and L-2-acetamido-6-oxoheptanedioate”
obsolete L-lysine biosynthetic process via diaminopimelate and L-2-acetamido-6-oxoheptanedioate comment “The reason for obsoletion is that this term represents a GO-CAM model.”
obsolete L-lysine biosynthetic process via diaminopimelate and L-2-acetamido-6-oxoheptanedioate deprecated true
obsolete L-lysine biosynthetic process via diaminopimelate and L-2-acetamido-6-oxoheptanedioate definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and L-2-acetamido-6-oxoheptanedioate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps.”
- database_cross_reference “GOC:mah”

obsolete L-lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate `http://purl.obolibrary.org/obo/GO_0033359`

Removed

obsolete L-lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate label “L-lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate”
obsolete L-lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate database_cross_reference “MetaCyc:DAPLYSINESYN-PWY”
obsolete L-lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate definition “The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and N-succinyl-2-amino-6-ketopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps.”
- database_cross_reference “GOC:mah”
- database_cross_reference “MetaCyc:DAPLYSINESYN-PWY”
obsolete L-lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate SubClassOf obsolete L-lysine biosynthetic process via diaminopimelate

Added

obsolete L-lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate term replaced by L-lysine biosynthetic process
obsolete L-lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate comment “The reason for obsoletion is that this term represents a GO-CAM model.”
obsolete L-lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate deprecated true
obsolete L-lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and N-succinyl-2-amino-6-ketopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps.”
- database_cross_reference “GOC:mah”
obsolete L-lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate label “obsolete L-lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate”

obsolete L-lysine biosynthetic process via diaminopimelate, dehydrogenase pathway `http://purl.obolibrary.org/obo/GO_0033361`

Removed

obsolete L-lysine biosynthetic process via diaminopimelate, dehydrogenase pathway label “L-lysine biosynthetic process via diaminopimelate, dehydrogenase pathway”
obsolete L-lysine biosynthetic process via diaminopimelate, dehydrogenase pathway database_cross_reference “MetaCyc:PWY-2942”
obsolete L-lysine biosynthetic process via diaminopimelate, dehydrogenase pathway definition “The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in a single enzymatic step.”
- database_cross_reference “GOC:mah”
- database_cross_reference “MetaCyc:PWY-2942”
- database_cross_reference “GOC:pr”
obsolete L-lysine biosynthetic process via diaminopimelate, dehydrogenase pathway SubClassOf obsolete L-lysine biosynthetic process via diaminopimelate
obsolete L-lysine biosynthetic process via diaminopimelate, dehydrogenase pathway SubClassOf has part some diaminopimelate dehydrogenase activity

Added

obsolete L-lysine biosynthetic process via diaminopimelate, dehydrogenase pathway definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in a single enzymatic step.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:pr”
obsolete L-lysine biosynthetic process via diaminopimelate, dehydrogenase pathway label “obsolete L-lysine biosynthetic process via diaminopimelate, dehydrogenase pathway”
obsolete L-lysine biosynthetic process via diaminopimelate, dehydrogenase pathway comment “The reason for obsoletion is that this term represents a GO-CAM model.”
obsolete L-lysine biosynthetic process via diaminopimelate, dehydrogenase pathway deprecated true
obsolete L-lysine biosynthetic process via diaminopimelate, dehydrogenase pathway term replaced by L-lysine biosynthetic process
obsolete L-lysine biosynthetic process via diaminopimelate, dehydrogenase pathway term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI

obsolete L-lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway `http://purl.obolibrary.org/obo/GO_0033362`

Removed

obsolete L-lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway definition “The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in two enzymatic steps.”
- database_cross_reference “GOC:mah”
- database_cross_reference “MetaCyc:PWY-5097”
- database_cross_reference “GOC:pr”
obsolete L-lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway label “L-lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway”
obsolete L-lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway database_cross_reference “MetaCyc:PWY-5097”
obsolete L-lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway SubClassOf obsolete L-lysine biosynthetic process via diaminopimelate
obsolete L-lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway SubClassOf has part some diaminopimelate epimerase activity
obsolete L-lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway SubClassOf has part some L,L-diaminopimelate:2-oxoglutarate transaminase activity

Added

obsolete L-lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway comment “The reason for obsoletion is that this term represents a GO-CAM model.”
obsolete L-lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway term replaced by L-lysine biosynthetic process
obsolete L-lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
obsolete L-lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway label “obsolete L-lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway”
obsolete L-lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in two enzymatic steps.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:pr”
obsolete L-lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway deprecated true

obsolete L-lysine catabolic process to acetyl-CoA `http://purl.obolibrary.org/obo/GO_0019474`

Removed

obsolete L-lysine catabolic process to acetyl-CoA definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA.”
- database_cross_reference “GOC:go_curators”

Added

obsolete L-lysine catabolic process to acetyl-CoA definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA.”
- database_cross_reference “GOC:curators”

obsolete L-lysine catabolic process to acetyl-CoA via 5-aminopentanamide `http://purl.obolibrary.org/obo/GO_0033513`

Removed

obsolete L-lysine catabolic process to acetyl-CoA via 5-aminopentanamide definition “The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate 5-aminopentanamide.”
- database_cross_reference “GOC:mah”
- database_cross_reference “MetaCyc:PWY-5280”
obsolete L-lysine catabolic process to acetyl-CoA via 5-aminopentanamide label “L-lysine catabolic process to acetyl-CoA via 5-aminopentanamide”
obsolete L-lysine catabolic process to acetyl-CoA via 5-aminopentanamide SubClassOf L-lysine catabolic process
obsolete L-lysine catabolic process to acetyl-CoA via 5-aminopentanamide SubClassOf acetyl-CoA metabolic process

Added

obsolete L-lysine catabolic process to acetyl-CoA via 5-aminopentanamide term replaced by L-lysine catabolic process
obsolete L-lysine catabolic process to acetyl-CoA via 5-aminopentanamide term tracker item “https://github.com/geneontology/go-ontology/issues/30202”^^anyURI
obsolete L-lysine catabolic process to acetyl-CoA via 5-aminopentanamide definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate 5-aminopentanamide.”
- database_cross_reference “GOC:mah”
- database_cross_reference “MetaCyc:PWY-5280”
obsolete L-lysine catabolic process to acetyl-CoA via 5-aminopentanamide label “obsolete L-lysine catabolic process to acetyl-CoA via 5-aminopentanamide”
obsolete L-lysine catabolic process to acetyl-CoA via 5-aminopentanamide comment “This term was obsoleted because it represents a specific instance of a pathway that should be captured as a GO-CAM model.”
obsolete L-lysine catabolic process to acetyl-CoA via 5-aminopentanamide deprecated true

obsolete L-lysine catabolic process to acetyl-CoA via L-pipecolate `http://purl.obolibrary.org/obo/GO_0033514`

Removed

obsolete L-lysine catabolic process to acetyl-CoA via L-pipecolate label “L-lysine catabolic process to acetyl-CoA via L-pipecolate”
obsolete L-lysine catabolic process to acetyl-CoA via L-pipecolate definition “The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate L-pipecolate.”
- database_cross_reference “MetaCyc:PWY66-425”
- database_cross_reference “GOC:mah”
obsolete L-lysine catabolic process to acetyl-CoA via L-pipecolate SubClassOf acetyl-CoA metabolic process
obsolete L-lysine catabolic process to acetyl-CoA via L-pipecolate SubClassOf L-lysine catabolic process

Added

obsolete L-lysine catabolic process to acetyl-CoA via L-pipecolate term replaced by L-lysine catabolic process
obsolete L-lysine catabolic process to acetyl-CoA via L-pipecolate comment “This term was obsoleted because it represents a specific instance of a pathway that should be captured as a GO-CAM model.”
obsolete L-lysine catabolic process to acetyl-CoA via L-pipecolate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate L-pipecolate.”
- database_cross_reference “MetaCyc:PWY66-425”
- database_cross_reference “GOC:mah”
obsolete L-lysine catabolic process to acetyl-CoA via L-pipecolate term tracker item “https://github.com/geneontology/go-ontology/issues/30202”^^anyURI
obsolete L-lysine catabolic process to acetyl-CoA via L-pipecolate label “obsolete L-lysine catabolic process to acetyl-CoA via L-pipecolate”
obsolete L-lysine catabolic process to acetyl-CoA via L-pipecolate deprecated true

obsolete L-lysine catabolic process to acetyl-CoA via L-saccharopine `http://purl.obolibrary.org/obo/GO_0033512`

Removed

obsolete L-lysine catabolic process to acetyl-CoA via L-saccharopine definition “The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate L-saccharopine.”
- database_cross_reference “GOC:mah”
- database_cross_reference “MetaCyc:LYSINE-DEG1-PWY”
obsolete L-lysine catabolic process to acetyl-CoA via L-saccharopine label “L-lysine catabolic process to acetyl-CoA via L-saccharopine”
obsolete L-lysine catabolic process to acetyl-CoA via L-saccharopine SubClassOf L-lysine catabolic process
obsolete L-lysine catabolic process to acetyl-CoA via L-saccharopine SubClassOf acetyl-CoA metabolic process

Added

obsolete L-lysine catabolic process to acetyl-CoA via L-saccharopine term replaced by L-lysine catabolic process
obsolete L-lysine catabolic process to acetyl-CoA via L-saccharopine deprecated true
obsolete L-lysine catabolic process to acetyl-CoA via L-saccharopine comment “This term was obsoleted because it represents a specific instance of a pathway that should be captured as a GO-CAM model.”
obsolete L-lysine catabolic process to acetyl-CoA via L-saccharopine term tracker item “https://github.com/geneontology/go-ontology/issues/30202”^^anyURI
obsolete L-lysine catabolic process to acetyl-CoA via L-saccharopine definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate L-saccharopine.”
- database_cross_reference “GOC:mah”
- database_cross_reference “MetaCyc:LYSINE-DEG1-PWY”
obsolete L-lysine catabolic process to acetyl-CoA via L-saccharopine label “obsolete L-lysine catabolic process to acetyl-CoA via L-saccharopine”

obsolete L-lysine catabolic process to glutarate, by acetylation `http://purl.obolibrary.org/obo/GO_0019473`

Removed

obsolete L-lysine catabolic process to glutarate, by acetylation definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including glutarate, by acetylation.”
- database_cross_reference “GOC:go_curators”

Added

obsolete L-lysine catabolic process to glutarate, by acetylation definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including glutarate, by acetylation.”
- database_cross_reference “GOC:curators”

obsolete L-methionine biosynthetic process from L-homoserine via O-acetyl-L-homoserine `http://purl.obolibrary.org/obo/GO_0019280`

Removed

obsolete L-methionine biosynthetic process from L-homoserine via O-acetyl-L-homoserine definition “The chemical reactions and pathways resulting in the formation of methionine from L-homoserine, via the intermediate O-acetyl-L-homoserine using sulfur from hydrogen sulfide assimilation.”
- database_cross_reference “MetaCyc:HSERMETANA-PWY”
obsolete L-methionine biosynthetic process from L-homoserine via O-acetyl-L-homoserine database_cross_reference “MetaCyc:HSERMETANA-PWY”
obsolete L-methionine biosynthetic process from L-homoserine via O-acetyl-L-homoserine label “L-methionine biosynthetic process from L-homoserine via O-acetyl-L-homoserine”
obsolete L-methionine biosynthetic process from L-homoserine via O-acetyl-L-homoserine SubClassOf L-homoserine metabolic process
obsolete L-methionine biosynthetic process from L-homoserine via O-acetyl-L-homoserine SubClassOf L-methionine biosynthetic process

Added

obsolete L-methionine biosynthetic process from L-homoserine via O-acetyl-L-homoserine term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
obsolete L-methionine biosynthetic process from L-homoserine via O-acetyl-L-homoserine definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of methionine from L-homoserine, via the intermediate O-acetyl-L-homoserine using sulfur from hydrogen sulfide assimilation.”
- database_cross_reference “MetaCyc:HSERMETANA-PWY”
obsolete L-methionine biosynthetic process from L-homoserine via O-acetyl-L-homoserine comment “This term was obsoleted because it represents a specific pathway beyond the specificity of GO.”
obsolete L-methionine biosynthetic process from L-homoserine via O-acetyl-L-homoserine deprecated true
obsolete L-methionine biosynthetic process from L-homoserine via O-acetyl-L-homoserine label “obsolete L-methionine biosynthetic process from L-homoserine via O-acetyl-L-homoserine”
obsolete L-methionine biosynthetic process from L-homoserine via O-acetyl-L-homoserine term replaced by ‘de novo’ L-methionine biosynthetic process

obsolete L-methionine biosynthetic process from L-homoserine via O-phospho-L-homoserine and cystathionine `http://purl.obolibrary.org/obo/GO_0019283`

Removed

obsolete L-methionine biosynthetic process from L-homoserine via O-phospho-L-homoserine and cystathionine definition “he chemical reactions and pathways resulting in the formation of L-methionine from L-homoserine, via the intermediates O-phospho-L-homoserine and cystathionine.”
- database_cross_reference “MetaCyc:PWY-702”
- database_cross_reference “GOC:go_curators”
obsolete L-methionine biosynthetic process from L-homoserine via O-phospho-L-homoserine and cystathionine label “L-methionine biosynthetic process from L-homoserine via O-phospho-L-homoserine and cystathionine”
obsolete L-methionine biosynthetic process from L-homoserine via O-phospho-L-homoserine and cystathionine database_cross_reference “MetaCyc:PWY-702”
obsolete L-methionine biosynthetic process from L-homoserine via O-phospho-L-homoserine and cystathionine SubClassOf organophosphate metabolic process
obsolete L-methionine biosynthetic process from L-homoserine via O-phospho-L-homoserine and cystathionine SubClassOf phosphate-containing compound metabolic process
obsolete L-methionine biosynthetic process from L-homoserine via O-phospho-L-homoserine and cystathionine SubClassOf L-homoserine metabolic process
obsolete L-methionine biosynthetic process from L-homoserine via O-phospho-L-homoserine and cystathionine SubClassOf ‘de novo’ L-methionine biosynthetic process
obsolete L-methionine biosynthetic process from L-homoserine via O-phospho-L-homoserine and cystathionine SubClassOf modified amino acid metabolic process

Added

obsolete L-methionine biosynthetic process from L-homoserine via O-phospho-L-homoserine and cystathionine definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of L-methionine from L-homoserine, via the intermediates O-phospho-L-homoserine and cystathionine.”
- database_cross_reference “GOC:curators”
- database_cross_reference “MetaCyc:PWY-702”
obsolete L-methionine biosynthetic process from L-homoserine via O-phospho-L-homoserine and cystathionine term replaced by ‘de novo’ L-methionine biosynthetic process
obsolete L-methionine biosynthetic process from L-homoserine via O-phospho-L-homoserine and cystathionine term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
obsolete L-methionine biosynthetic process from L-homoserine via O-phospho-L-homoserine and cystathionine comment “This term was obsoleted because it represents a specific pathway beyond the specificity of GO.”
obsolete L-methionine biosynthetic process from L-homoserine via O-phospho-L-homoserine and cystathionine label “obsolete L-methionine biosynthetic process from L-homoserine via O-phospho-L-homoserine and cystathionine”
obsolete L-methionine biosynthetic process from L-homoserine via O-phospho-L-homoserine and cystathionine deprecated true

obsolete L-methionine biosynthetic process from L-homoserine via cystathionine `http://purl.obolibrary.org/obo/GO_0019279`

Removed

obsolete L-methionine biosynthetic process from L-homoserine via cystathionine label “L-methionine biosynthetic process from L-homoserine via cystathionine”
obsolete L-methionine biosynthetic process from L-homoserine via cystathionine database_cross_reference “MetaCyc:HOMOSER-METSYN-PWY”
obsolete L-methionine biosynthetic process from L-homoserine via cystathionine definition “The chemical reactions and pathways resulting in the formation of L-methionine from L-homoserine, via the intermediate cystathionine.”
- database_cross_reference “MetaCyc:HOMOSER-METSYN-PWY”
obsolete L-methionine biosynthetic process from L-homoserine via cystathionine SubClassOf L-methionine biosynthetic process
obsolete L-methionine biosynthetic process from L-homoserine via cystathionine SubClassOf L-homoserine metabolic process

Added

obsolete L-methionine biosynthetic process from L-homoserine via cystathionine term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
obsolete L-methionine biosynthetic process from L-homoserine via cystathionine term replaced by ‘de novo’ L-methionine biosynthetic process
obsolete L-methionine biosynthetic process from L-homoserine via cystathionine deprecated true
obsolete L-methionine biosynthetic process from L-homoserine via cystathionine comment “This term was obsoleted because it represents a specific pathway beyond the specificity of GO.”
obsolete L-methionine biosynthetic process from L-homoserine via cystathionine label “obsolete L-methionine biosynthetic process from L-homoserine via cystathionine”
obsolete L-methionine biosynthetic process from L-homoserine via cystathionine definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of L-methionine from L-homoserine, via the intermediate cystathionine.”
- database_cross_reference “MetaCyc:HOMOSER-METSYN-PWY”

obsolete L-methionine biosynthetic process from homoserine via O-phospho-L-homoserine and cystathionine `http://purl.obolibrary.org/obo/GO_0033516`

Removed

obsolete L-methionine biosynthetic process from homoserine via O-phospho-L-homoserine and cystathionine term replaced by obsolete L-methionine biosynthetic process from L-homoserine via O-phospho-L-homoserine and cystathionine

Added

obsolete L-methionine biosynthetic process from homoserine via O-phospho-L-homoserine and cystathionine term replaced by ‘de novo’ L-methionine biosynthetic process

obsolete L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine `http://purl.obolibrary.org/obo/GO_0019281`

Removed

obsolete L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine definition “The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-succinyl-L-homoserine and cystathionine.”
- database_cross_reference “MetaCyc:MET-SAM-PWY”
obsolete L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine label “L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine”
obsolete L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine database_cross_reference “MetaCyc:MET-SAM-PWY”
obsolete L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine SubClassOf obsolete L-methionine biosynthetic process from L-homoserine via cystathionine

Added

obsolete L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine label “obsolete L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine”
obsolete L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine comment “This term was obsoleted because it represents a specific pathway beyond the specificity of GO.”
obsolete L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine deprecated true
obsolete L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine term replaced by ‘de novo’ L-methionine biosynthetic process
obsolete L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-succinyl-L-homoserine and cystathionine.”
- database_cross_reference “GOC:curators”
obsolete L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI

obsolete L-methionine catabolic process to succinyl-CoA `http://purl.obolibrary.org/obo/GO_0019457`

Removed

obsolete L-methionine catabolic process to succinyl-CoA definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-methionine into other compounds, including succinyl-CoA.”
- database_cross_reference “GOC:go_curators”

Added

obsolete L-methionine catabolic process to succinyl-CoA definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-methionine into other compounds, including succinyl-CoA.”
- database_cross_reference “GOC:curators”

obsolete L-methionine catabolic process via 2-oxobutanoate `http://purl.obolibrary.org/obo/GO_0019458`

Removed

obsolete L-methionine catabolic process via 2-oxobutanoate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-methionine, via the intermediate 2-oxobutanoate.”
- database_cross_reference “GOC:go_curators”

Added

obsolete L-methionine catabolic process via 2-oxobutanoate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-methionine, via the intermediate 2-oxobutanoate.”
- database_cross_reference “GOC:curators”

obsolete L-methionine salvage from S-adenosylmethionine `http://purl.obolibrary.org/obo/GO_0019284`

Removed

obsolete L-methionine salvage from S-adenosylmethionine definition “The chemical reactions and pathways resulting in the formation of L-methionine from S-adenosylmethionine.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:vw”
- database_cross_reference “PMID:31950558”
obsolete L-methionine salvage from S-adenosylmethionine label “L-methionine salvage from S-adenosylmethionine”
obsolete L-methionine salvage from S-adenosylmethionine SubClassOf part of some L-methionine cycle
obsolete L-methionine salvage from S-adenosylmethionine SubClassOf L-methionine salvage

Added

obsolete L-methionine salvage from S-adenosylmethionine consider L-methionine cycle
obsolete L-methionine salvage from S-adenosylmethionine deprecated true
obsolete L-methionine salvage from S-adenosylmethionine definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of L-methionine from S-adenosylmethionine.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:vw”
- database_cross_reference “PMID:31950558”
obsolete L-methionine salvage from S-adenosylmethionine label “obsolete L-methionine salvage from S-adenosylmethionine”
obsolete L-methionine salvage from S-adenosylmethionine consider L-methionine salvage
obsolete L-methionine salvage from S-adenosylmethionine term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
obsolete L-methionine salvage from S-adenosylmethionine comment “This term was obsoleted because it was not clearly defined and usage has been inconsistent.”

obsolete L-methionine salvage from methylthioadenosine `http://purl.obolibrary.org/obo/GO_0019509`

Removed

obsolete L-methionine salvage from methylthioadenosine database_cross_reference “MetaCyc:PWY-6754”
obsolete L-methionine salvage from methylthioadenosine definition “The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine.”
- database_cross_reference “MetaCyc:PWY-4361”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:19946895”
obsolete L-methionine salvage from methylthioadenosine database_cross_reference “MetaCyc:PWY-4361”
obsolete L-methionine salvage from methylthioadenosine label “L-methionine salvage from methylthioadenosine”
obsolete L-methionine salvage from methylthioadenosine database_cross_reference “MetaCyc:PWY-6756”
obsolete L-methionine salvage from methylthioadenosine database_cross_reference “MetaCyc:PWY-6753”
obsolete L-methionine salvage from methylthioadenosine SubClassOf L-methionine salvage

Added

obsolete L-methionine salvage from methylthioadenosine deprecated true
obsolete L-methionine salvage from methylthioadenosine term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
obsolete L-methionine salvage from methylthioadenosine label “obsolete L-methionine salvage from methylthioadenosine”
obsolete L-methionine salvage from methylthioadenosine term tracker item “https://github.com/geneontology/go-ontology/issues/31318”^^anyURI
obsolete L-methionine salvage from methylthioadenosine term replaced by L-methionine cycle
obsolete L-methionine salvage from methylthioadenosine definition “OBSOLETE. The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:19946895”
obsolete L-methionine salvage from methylthioadenosine comment “This term was obsoleted because it represents a specific pathway beyond the specificity of GO.”

obsolete L-ornithine catabolic process via proline `http://purl.obolibrary.org/obo/GO_0019466`

Removed

obsolete L-ornithine catabolic process via proline definition “The chemical reactions and pathways resulting in the breakdown of L-ornithine, via the intermediate proline.”
- database_cross_reference “GOC:go_curators”
obsolete L-ornithine catabolic process via proline label “L-ornithine catabolic process via proline”
obsolete L-ornithine catabolic process via proline database_cross_reference “MetaCyc:ORN-AMINOPENTANOATE-CAT-PWY”
obsolete L-ornithine catabolic process via proline SubClassOf L-ornithine catabolic process

Added

obsolete L-ornithine catabolic process via proline term tracker item “https://github.com/geneontology/go-ontology/issues/31361”^^anyURI
obsolete L-ornithine catabolic process via proline definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-ornithine, via the intermediate proline.”
- database_cross_reference “GOC:curators”
obsolete L-ornithine catabolic process via proline label “obsolete L-ornithine catabolic process via proline”
obsolete L-ornithine catabolic process via proline comment “This term was obsoleted because it represents a variant pathway of L-ornithine degradation and is out of scope for GO.”
obsolete L-ornithine catabolic process via proline deprecated true
obsolete L-ornithine catabolic process via proline term replaced by L-ornithine catabolic process

obsolete L-ornithine catabolic process, by decarboxylation `http://purl.obolibrary.org/obo/GO_0019467`

Removed

obsolete L-ornithine catabolic process, by decarboxylation definition “The chemical reactions and pathways resulting in the breakdown of L-ornithine by decarboxylation.”
- database_cross_reference “GOC:go_curators”
obsolete L-ornithine catabolic process, by decarboxylation label “L-ornithine catabolic process, by decarboxylation”
obsolete L-ornithine catabolic process, by decarboxylation SubClassOf L-ornithine catabolic process
obsolete L-ornithine catabolic process, by decarboxylation SubClassOf has part some carboxy-lyase activity

Added

obsolete L-ornithine catabolic process, by decarboxylation term replaced by L-ornithine catabolic process
obsolete L-ornithine catabolic process, by decarboxylation deprecated true
obsolete L-ornithine catabolic process, by decarboxylation definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-ornithine by decarboxylation.”
- database_cross_reference “GOC:curators”
obsolete L-ornithine catabolic process, by decarboxylation label “obsolete L-ornithine catabolic process, by decarboxylation”
obsolete L-ornithine catabolic process, by decarboxylation comment “This term was obsoleted because it represents a variant pathway of L-ornithine degradation and is out of scope for GO.”
obsolete L-ornithine catabolic process, by decarboxylation term tracker item “https://github.com/geneontology/go-ontology/issues/31361”^^anyURI

obsolete L-phenylalanine biosynthetic process from chorismate via L-arogenate `http://purl.obolibrary.org/obo/GO_0033586`

Removed

obsolete L-phenylalanine biosynthetic process from chorismate via L-arogenate database_cross_reference “MetaCyc:PWY-3462”
obsolete L-phenylalanine biosynthetic process from chorismate via L-arogenate label “L-phenylalanine biosynthetic process from chorismate via L-arogenate”
obsolete L-phenylalanine biosynthetic process from chorismate via L-arogenate definition “The chemical reactions and pathways resulting in the formation of L-phenylalanine from other compounds, including chorismate, via the intermediate L-arogenate.”
- database_cross_reference “GOC:go_curators”
obsolete L-phenylalanine biosynthetic process from chorismate via L-arogenate SubClassOf chorismate metabolic process
obsolete L-phenylalanine biosynthetic process from chorismate via L-arogenate SubClassOf L-phenylalanine biosynthetic process
obsolete L-phenylalanine biosynthetic process from chorismate via L-arogenate SubClassOf aromatic amino acid family biosynthetic process, prephenate pathway

Added

obsolete L-phenylalanine biosynthetic process from chorismate via L-arogenate deprecated true
obsolete L-phenylalanine biosynthetic process from chorismate via L-arogenate label “obsolete L-phenylalanine biosynthetic process from chorismate via L-arogenate”
obsolete L-phenylalanine biosynthetic process from chorismate via L-arogenate definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of L-phenylalanine from other compounds, including chorismate, via the intermediate L-arogenate.”
- database_cross_reference “GOC:curators”
obsolete L-phenylalanine biosynthetic process from chorismate via L-arogenate comment “The reason for obsoletion is that this term represents a GO-CAM model.”
obsolete L-phenylalanine biosynthetic process from chorismate via L-arogenate term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
obsolete L-phenylalanine biosynthetic process from chorismate via L-arogenate term replaced by L-phenylalanine biosynthetic process

obsolete L-phenylalanine biosynthetic process from chorismate via phenylpyruvate `http://purl.obolibrary.org/obo/GO_0033585`

Removed

obsolete L-phenylalanine biosynthetic process from chorismate via phenylpyruvate definition “The chemical reactions and pathways resulting in the formation of L-phenylalanine from other compounds, including chorismate, via the intermediate phenylpyruvate.”
- database_cross_reference “GOC:go_curators”
obsolete L-phenylalanine biosynthetic process from chorismate via phenylpyruvate database_cross_reference “MetaCyc:PHESYN”
obsolete L-phenylalanine biosynthetic process from chorismate via phenylpyruvate label “L-phenylalanine biosynthetic process from chorismate via phenylpyruvate”
obsolete L-phenylalanine biosynthetic process from chorismate via phenylpyruvate SubClassOf chorismate metabolic process
obsolete L-phenylalanine biosynthetic process from chorismate via phenylpyruvate SubClassOf L-phenylalanine biosynthetic process

Added

obsolete L-phenylalanine biosynthetic process from chorismate via phenylpyruvate deprecated true
obsolete L-phenylalanine biosynthetic process from chorismate via phenylpyruvate definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of L-phenylalanine from other compounds, including chorismate, via the intermediate phenylpyruvate.”
- database_cross_reference “GOC:curators”
obsolete L-phenylalanine biosynthetic process from chorismate via phenylpyruvate comment “The reason for obsoletion is that this term represents a GO-CAM model.”
obsolete L-phenylalanine biosynthetic process from chorismate via phenylpyruvate label “obsolete L-phenylalanine biosynthetic process from chorismate via phenylpyruvate”
obsolete L-phenylalanine biosynthetic process from chorismate via phenylpyruvate term replaced by L-phenylalanine biosynthetic process
obsolete L-phenylalanine biosynthetic process from chorismate via phenylpyruvate term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI

obsolete L-phenylalanine catabolic process to phosphoenolpyruvate `http://purl.obolibrary.org/obo/GO_0019562`

Removed

obsolete L-phenylalanine catabolic process to phosphoenolpyruvate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-phenylalanine into other compounds, including phosphoenolpyruvate.”
- database_cross_reference “GOC:go_curators”

Added

obsolete L-phenylalanine catabolic process to phosphoenolpyruvate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-phenylalanine into other compounds, including phosphoenolpyruvate.”
- database_cross_reference “GOC:curators”

obsolete L-proline betaine biosynthetic process `http://purl.obolibrary.org/obo/GO_0019503`

Removed

obsolete L-proline betaine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline.”
- database_cross_reference “PMID:14367364”
- database_cross_reference “GOC:ai”
obsolete L-proline betaine biosynthetic process label “L-proline betaine biosynthetic process”
obsolete L-proline betaine biosynthetic process SubClassOf amino-acid betaine biosynthetic process
obsolete L-proline betaine biosynthetic process SubClassOf alkaloid biosynthetic process
obsolete L-proline betaine biosynthetic process SubClassOf non-proteinogenic amino acid biosynthetic process
obsolete L-proline betaine biosynthetic process SubClassOf L-amino acid biosynthetic process

Added

obsolete L-proline betaine biosynthetic process label “obsolete L-proline betaine biosynthetic process”
obsolete L-proline betaine biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline.”
- database_cross_reference “PMID:14367364”
- database_cross_reference “GOC:ai”
obsolete L-proline betaine biosynthetic process deprecated true
obsolete L-proline betaine biosynthetic process comment “The reason for merging the above terms is to clean up this branch, consistent to what has been done previously.”
obsolete L-proline betaine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31510”^^anyURI

obsolete L-proline salvage `http://purl.obolibrary.org/obo/GO_0019492`

Removed

obsolete L-proline salvage definition “Any process which produces L-proline from derivatives of it, without de novo synthesis.”
- database_cross_reference “GOC:jl”
obsolete L-proline salvage label “L-proline salvage”
obsolete L-proline salvage SubClassOf L-proline biosynthetic process
obsolete L-proline salvage SubClassOf amino acid salvage

Added

obsolete L-proline salvage term replaced by L-proline biosynthetic process
obsolete L-proline salvage comment “The reason for obsoletion is that this term represents a GO-CAM model.”
obsolete L-proline salvage term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
obsolete L-proline salvage definition “OBSOLETE. Any process which produces L-proline from derivatives of it, without de novo synthesis.”
- database_cross_reference “GOC:jl”
obsolete L-proline salvage label “obsolete L-proline salvage”
obsolete L-proline salvage deprecated true

obsolete L-tryptophan catabolic process to L-kynurenine `http://purl.obolibrary.org/obo/GO_0019441`

Removed

obsolete L-tryptophan catabolic process to L-kynurenine definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-tryptophan into other compounds, including L-kynurenine.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:31704347”

Added

obsolete L-tryptophan catabolic process to L-kynurenine definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-tryptophan into other compounds, including L-kynurenine.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:31704347”

obsolete L-tryptophan catabolic process to acetyl-CoA `http://purl.obolibrary.org/obo/GO_0019442`

Removed

obsolete L-tryptophan catabolic process to acetyl-CoA definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-tryptophan into other compounds, including acetyl-CoA.”
- database_cross_reference “GOC:go_curators”

Added

obsolete L-tryptophan catabolic process to acetyl-CoA definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-tryptophan into other compounds, including acetyl-CoA.”
- database_cross_reference “GOC:curators”

obsolete L-tryptophan catabolic process to catechol `http://purl.obolibrary.org/obo/GO_0019444`

Removed

obsolete L-tryptophan catabolic process to catechol definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-tryptophan into other compounds, including catechol.”
- database_cross_reference “GOC:go_curators”

Added

obsolete L-tryptophan catabolic process to catechol definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-tryptophan into other compounds, including catechol.”
- database_cross_reference “GOC:curators”

obsolete L-tryptophan catabolic process to indole-3-acetate `http://purl.obolibrary.org/obo/GO_0019440`

Removed

obsolete L-tryptophan catabolic process to indole-3-acetate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-tryptophan into other compounds, including indole-3-acetate.”
- database_cross_reference “GOC:go_curators”

Added

obsolete L-tryptophan catabolic process to indole-3-acetate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-tryptophan into other compounds, including indole-3-acetate.”
- database_cross_reference “GOC:curators”

obsolete L-tryptophan transaminase activity `http://purl.obolibrary.org/obo/GO_0070529`

Removed

obsolete L-tryptophan transaminase activity label “L-tryptophan aminotransferase activity”
obsolete L-tryptophan transaminase activity definition “Catalysis of the transfer of an amino group from L-tryptophan to an acceptor, usually a 2-oxo acid.”
- database_cross_reference “GOC:mah”
obsolete L-tryptophan transaminase activity SubClassOf transaminase activity

Added

obsolete L-tryptophan transaminase activity definition “OBSOLETE. Catalysis of the transfer of an amino group from L-tryptophan to an acceptor, usually a 2-oxo acid.”
- database_cross_reference “GOC:mah”
obsolete L-tryptophan transaminase activity deprecated true
obsolete L-tryptophan transaminase activity comment “This term was obsoleted because it is an unnecessary grouping term.”
obsolete L-tryptophan transaminase activity term replaced by L-tryptophan:phenylpyruvate transaminase activity
obsolete L-tryptophan transaminase activity label “obsolete L-tryptophan transaminase activity”
obsolete L-tryptophan transaminase activity has_exact_synonym “L-tryptophan aminotransferase activity”
obsolete L-tryptophan transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI

obsolete L-tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate `http://purl.obolibrary.org/obo/GO_0019292`

Removed

obsolete L-tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate definition “The chemical reactions and pathways resulting in the formation of L-tyrosine from other compounds, including chorismate, via the intermediate 4-hydroxyphenylpyruvate.”
- database_cross_reference “GOC:go_curators”
obsolete L-tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate label “L-tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate”
obsolete L-tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate database_cross_reference “MetaCyc:TYRSYN”
obsolete L-tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate SubClassOf L-tyrosine biosynthetic process
obsolete L-tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate SubClassOf chorismate metabolic process

Added

obsolete L-tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate term replaced by L-tyrosine biosynthetic process
obsolete L-tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate comment “The reason for obsoletion is that this term represents a GO-CAM model.”
obsolete L-tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate deprecated true
obsolete L-tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
obsolete L-tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate label “obsolete L-tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate”
obsolete L-tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of L-tyrosine from other compounds, including chorismate, via the intermediate 4-hydroxyphenylpyruvate.”
- database_cross_reference “GOC:curators”

obsolete L-tyrosine biosynthetic process from chorismate via L-arogenate `http://purl.obolibrary.org/obo/GO_0033584`

Removed

obsolete L-tyrosine biosynthetic process from chorismate via L-arogenate definition “The chemical reactions and pathways resulting in the formation of L-tyrosine from other compounds, including chorismate, via the intermediate L-arogenate.”
- database_cross_reference “GOC:mah”
obsolete L-tyrosine biosynthetic process from chorismate via L-arogenate database_cross_reference “MetaCyc:PWY-3461”
obsolete L-tyrosine biosynthetic process from chorismate via L-arogenate label “L-tyrosine biosynthetic process from chorismate via L-arogenate”
obsolete L-tyrosine biosynthetic process from chorismate via L-arogenate SubClassOf chorismate metabolic process
obsolete L-tyrosine biosynthetic process from chorismate via L-arogenate SubClassOf L-tyrosine biosynthetic process
obsolete L-tyrosine biosynthetic process from chorismate via L-arogenate SubClassOf aromatic amino acid family biosynthetic process, prephenate pathway

Added

obsolete L-tyrosine biosynthetic process from chorismate via L-arogenate deprecated true
obsolete L-tyrosine biosynthetic process from chorismate via L-arogenate definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of L-tyrosine from other compounds, including chorismate, via the intermediate L-arogenate.”
- database_cross_reference “GOC:mah”
obsolete L-tyrosine biosynthetic process from chorismate via L-arogenate term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
obsolete L-tyrosine biosynthetic process from chorismate via L-arogenate label “obsolete L-tyrosine biosynthetic process from chorismate via L-arogenate”
obsolete L-tyrosine biosynthetic process from chorismate via L-arogenate term replaced by L-tyrosine biosynthetic process
obsolete L-tyrosine biosynthetic process from chorismate via L-arogenate comment “The reason for obsoletion is that this term represents a GO-CAM model.”

obsolete L-tyrosine biosynthetic process, by oxidation of phenylalanine `http://purl.obolibrary.org/obo/GO_0019293`

Removed

obsolete L-tyrosine biosynthetic process, by oxidation of phenylalanine database_cross_reference “MetaCyc:PWY-6134”
obsolete L-tyrosine biosynthetic process, by oxidation of phenylalanine label “L-tyrosine biosynthetic process, by oxidation of phenylalanine”
obsolete L-tyrosine biosynthetic process, by oxidation of phenylalanine definition “The conversion of phenylalanine to tyrosine.”
- database_cross_reference “PMID:4004813”
obsolete L-tyrosine biosynthetic process, by oxidation of phenylalanine has_alternative_id “GO:0019291”
obsolete L-tyrosine biosynthetic process, by oxidation of phenylalanine SubClassOf L-tyrosine biosynthetic process

Added

obsolete L-tyrosine biosynthetic process, by oxidation of phenylalanine term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
obsolete L-tyrosine biosynthetic process, by oxidation of phenylalanine definition “OBSOLETE. The conversion of phenylalanine to tyrosine.”
- database_cross_reference “PMID:4004813”
obsolete L-tyrosine biosynthetic process, by oxidation of phenylalanine deprecated true
obsolete L-tyrosine biosynthetic process, by oxidation of phenylalanine label “obsolete L-tyrosine biosynthetic process, by oxidation of phenylalanine”
obsolete L-tyrosine biosynthetic process, by oxidation of phenylalanine comment “The reason for obsoletion is that this term represents a GO-CAM model”
obsolete L-tyrosine biosynthetic process, by oxidation of phenylalanine term replaced by L-tyrosine biosynthetic process

obsolete L-tyrosine catabolic process to fumarate `http://purl.obolibrary.org/obo/GO_0019445`

Removed

obsolete L-tyrosine catabolic process to fumarate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-tyrosine into other compounds, including fumarate.”
- database_cross_reference “GOC:go_curators”

Added

obsolete L-tyrosine catabolic process to fumarate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-tyrosine into other compounds, including fumarate.”
- database_cross_reference “GOC:curators”

obsolete Mn, Fe superoxide dismutase `http://purl.obolibrary.org/obo/GO_0004786`

Removed

obsolete Mn, Fe superoxide dismutase definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete Mn, Fe superoxide dismutase definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete N(omega),N(omega)-dimethyl-L-arginine catabolic process `http://purl.obolibrary.org/obo/GO_2001299`

Removed

obsolete N(omega),N(omega)-dimethyl-L-arginine catabolic process label “N(omega),N(omega)-dimethyl-L-arginine catabolic process”
obsolete N(omega),N(omega)-dimethyl-L-arginine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of N(omega),N(omega)-dimethyl-L-arginine, a methyl-L-arginine having two methyl groups both attached to the primary amino moiety of the guanidino group.”
- database_cross_reference “PMID:10510241”
- database_cross_reference “GOC:rs”
obsolete N(omega),N(omega)-dimethyl-L-arginine catabolic process SubClassOf L-amino acid catabolic process
obsolete N(omega),N(omega)-dimethyl-L-arginine catabolic process SubClassOf non-proteinogenic amino acid catabolic process
obsolete N(omega),N(omega)-dimethyl-L-arginine catabolic process SubClassOf modified amino acid catabolic process

Added

obsolete N(omega),N(omega)-dimethyl-L-arginine catabolic process deprecated true
obsolete N(omega),N(omega)-dimethyl-L-arginine catabolic process label “obsolete N(omega),N(omega)-dimethyl-L-arginine catabolic process”
obsolete N(omega),N(omega)-dimethyl-L-arginine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31361”^^anyURI
obsolete N(omega),N(omega)-dimethyl-L-arginine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of N(omega),N(omega)-dimethyl-L-arginine, a methyl-L-arginine having two methyl groups both attached to the primary amino moiety of the guanidino group.”
- database_cross_reference “PMID:10510241”
- database_cross_reference “GOC:rs”
obsolete N(omega),N(omega)-dimethyl-L-arginine catabolic process comment “The reason for obsoletion is that there is no evidence that this function/process/component exists.”

obsolete N(omega)-methyl-L-arginine catabolic process `http://purl.obolibrary.org/obo/GO_2001297`

Removed

obsolete N(omega)-methyl-L-arginine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of N(omega)-methyl-L-arginine.”
- database_cross_reference “PMID:10510241”
- database_cross_reference “GOC:rs”
obsolete N(omega)-methyl-L-arginine catabolic process label “N(omega)-methyl-L-arginine catabolic process”
obsolete N(omega)-methyl-L-arginine catabolic process SubClassOf L-amino acid catabolic process
obsolete N(omega)-methyl-L-arginine catabolic process SubClassOf non-proteinogenic amino acid catabolic process
obsolete N(omega)-methyl-L-arginine catabolic process SubClassOf modified amino acid catabolic process

Added

obsolete N(omega)-methyl-L-arginine catabolic process label “obsolete N(omega)-methyl-L-arginine catabolic process”
obsolete N(omega)-methyl-L-arginine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31361”^^anyURI
obsolete N(omega)-methyl-L-arginine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of N(omega)-methyl-L-arginine.”
- database_cross_reference “PMID:10510241”
- database_cross_reference “GOC:rs”
obsolete N(omega)-methyl-L-arginine catabolic process deprecated true
obsolete N(omega)-methyl-L-arginine catabolic process comment “The reason for obsoletion is that there is no evidence that this function/process/component exists.”

obsolete N-acylsphingosine galactosyltransferase activity `http://purl.obolibrary.org/obo/GO_0047263`

Removed

obsolete N-acylsphingosine galactosyltransferase activity definition “OBSOLETE. Catalysis of the reaction: ceramide + UDP-galactose = D-galactosylceramide + UDP.”
- database_cross_reference “GOC:curator”

Added

obsolete N-acylsphingosine galactosyltransferase activity definition “OBSOLETE. Catalysis of the reaction: ceramide + UDP-galactose = D-galactosylceramide + UDP.”
- database_cross_reference “GOC:curators”

obsolete N-cyclopropylammelide alkylamino hydrolase activity `http://purl.obolibrary.org/obo/GO_0034549`

Removed

obsolete N-cyclopropylammelide alkylamino hydrolase activity label “N-cyclopropylammelide alkylamino hydrolase activity”
obsolete N-cyclopropylammelide alkylamino hydrolase activity definition “Catalysis of the reaction: N-cyclopropylammelide + H2O = cyclopropylamine + cyanuric acid.”
- database_cross_reference “UM-BBD_reactionID:r0827”
obsolete N-cyclopropylammelide alkylamino hydrolase activity SubClassOf hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

Added

obsolete N-cyclopropylammelide alkylamino hydrolase activity deprecated true
obsolete N-cyclopropylammelide alkylamino hydrolase activity definition “OBSOLETE. Catalysis of the reaction: N-cyclopropylammelide + H2O = cyclopropylamine + cyanuric acid.”
- database_cross_reference “UM-BBD_reactionID:r0827”
obsolete N-cyclopropylammelide alkylamino hydrolase activity comment “This term was obsoleted because there is no evidence that this reaction exists.”
obsolete N-cyclopropylammelide alkylamino hydrolase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31530”^^anyURI
obsolete N-cyclopropylammelide alkylamino hydrolase activity label “obsolete N-cyclopropylammelide alkylamino hydrolase activity”

obsolete N-cyclopropylammeline deaminase activity `http://purl.obolibrary.org/obo/GO_0034548`

Removed

obsolete N-cyclopropylammeline deaminase activity label “N-cyclopropylammeline deaminase activity”
obsolete N-cyclopropylammeline deaminase activity definition “Catalysis of the reaction: N-cyclopropylammeline + H2O = N-cyclopropylammelide + NH3.”
- database_cross_reference “UM-BBD_reactionID:r0826”
obsolete N-cyclopropylammeline deaminase activity SubClassOf hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

Added

obsolete N-cyclopropylammeline deaminase activity label “obsolete N-cyclopropylammeline deaminase activity”
obsolete N-cyclopropylammeline deaminase activity definition “OBSOLETE. Catalysis of the reaction: N-cyclopropylammeline + H2O = N-cyclopropylammelide + NH3.”
- database_cross_reference “UM-BBD_reactionID:r0826”
obsolete N-cyclopropylammeline deaminase activity deprecated true
obsolete N-cyclopropylammeline deaminase activity comment “This term was obsoleted because there is no evidence that this reaction exists.”
obsolete N-cyclopropylammeline deaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31530”^^anyURI

obsolete N-cyclopropylmelamine deaminase activity `http://purl.obolibrary.org/obo/GO_0034547`

Removed

obsolete N-cyclopropylmelamine deaminase activity label “N-cyclopropylmelamine deaminase activity”
obsolete N-cyclopropylmelamine deaminase activity definition “Catalysis of the reaction: cyromazine + H2O = N-cyclopropylammeline + NH3.”
- database_cross_reference “UM-BBD_reactionID:r0825”
obsolete N-cyclopropylmelamine deaminase activity SubClassOf hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

Added

obsolete N-cyclopropylmelamine deaminase activity deprecated true
obsolete N-cyclopropylmelamine deaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31530”^^anyURI
obsolete N-cyclopropylmelamine deaminase activity label “obsolete N-cyclopropylmelamine deaminase activity”
obsolete N-cyclopropylmelamine deaminase activity definition “OBSOLETE. Catalysis of the reaction: cyromazine + H2O = N-cyclopropylammeline + NH3.”
- database_cross_reference “UM-BBD_reactionID:r0825”
obsolete N-cyclopropylmelamine deaminase activity comment “This term was obsoleted because there is no evidence that this reaction exists.”

obsolete N-ethylammeline chlorohydrolase activity `http://purl.obolibrary.org/obo/GO_0016217`

Removed

obsolete N-ethylammeline chlorohydrolase activity definition “Catalysis of the reaction: deethylsimazine + H2O = N-ethylammeline + chloride + H+.”
- database_cross_reference “MetaCyc:R465-RXN”
obsolete N-ethylammeline chlorohydrolase activity label “N-ethylammeline chlorohydrolase activity”
obsolete N-ethylammeline chlorohydrolase activity database_cross_reference “MetaCyc:R465-RXN”
obsolete N-ethylammeline chlorohydrolase activity SubClassOf hydrolase activity, acting on halide bonds, in C-halide compounds

Added

obsolete N-ethylammeline chlorohydrolase activity definition “OBSOLETE. Catalysis of the reaction: deethylsimazine + H2O = N-ethylammeline + chloride + H+.”
- database_cross_reference “GOC:curators”
obsolete N-ethylammeline chlorohydrolase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete N-ethylammeline chlorohydrolase activity label “obsolete N-ethylammeline chlorohydrolase activity”
obsolete N-ethylammeline chlorohydrolase activity deprecated true
obsolete N-ethylammeline chlorohydrolase activity comment “This term was obsoleted because it represents a specific substrate.”

obsolete N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity `http://purl.obolibrary.org/obo/GO_0052904`

Removed

obsolete N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity database_cross_reference “Reactome:R-HSA-141351”
- label “PAOX:FAD oxidises NASPN to SPM”
obsolete N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity database_cross_reference “Reactome:R-HSA-141348”
- label “PAO:FAD oxidises NASPM to PTCN”

obsolete N6,N6-dimethyl-AMP deaminase activity `http://purl.obolibrary.org/obo/GO_7770049`

Added

obsolete N6,N6-dimethyl-AMP deaminase activity id “GO:7770049”
obsolete N6,N6-dimethyl-AMP deaminase activity definition “OBSOLETE. Catalysis of the reaction: H2O + H+ + N6,N6-dimethyl-AMP = IMP + dimethylamine.”
- database_cross_reference “PMID:40840445”
obsolete N6,N6-dimethyl-AMP deaminase activity has_obo_namespace “molecular_function”
obsolete N6,N6-dimethyl-AMP deaminase activity creation date “2026-02-09T05:59:37Z”
obsolete N6,N6-dimethyl-AMP deaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/30800”^^anyURI
obsolete N6,N6-dimethyl-AMP deaminase activity created by “dragon-ai-agent”
obsolete N6,N6-dimethyl-AMP deaminase activity comment “The reason for obsoletion is that this term was added in error.”
obsolete N6,N6-dimethyl-AMP deaminase activity deprecated true
obsolete N6,N6-dimethyl-AMP deaminase activity label “obsolete N6,N6-dimethyl-AMP deaminase activity”
Class: obsolete N6,N6-dimethyl-AMP deaminase activity

obsolete N6,N6-dimethyladenosine kinase activity `http://purl.obolibrary.org/obo/GO_7770047`

Added

obsolete N6,N6-dimethyladenosine kinase activity comment “The reason for obsoletion is that this term was added in error.”
obsolete N6,N6-dimethyladenosine kinase activity deprecated true
obsolete N6,N6-dimethyladenosine kinase activity label “obsolete N6,N6-dimethyladenosine kinase activity”
obsolete N6,N6-dimethyladenosine kinase activity created by “dragon-ai-agent”
obsolete N6,N6-dimethyladenosine kinase activity creation date “2026-02-09T05:59:37Z”
obsolete N6,N6-dimethyladenosine kinase activity has_obo_namespace “molecular_function”
obsolete N6,N6-dimethyladenosine kinase activity definition “OBSOLETE. Catalysis of the reaction: ATP + N6,N6-dimethyladenosine = ADP + H+ + N6,N6-dimethyl-AMP.”
- database_cross_reference “PMID:40840445”
obsolete N6,N6-dimethyladenosine kinase activity term tracker item “https://github.com/geneontology/go-ontology/issues/30800”^^anyURI
obsolete N6,N6-dimethyladenosine kinase activity id “GO:7770047”
Class: obsolete N6,N6-dimethyladenosine kinase activity

obsolete N6-isopentenyl-AMP deaminase activity `http://purl.obolibrary.org/obo/GO_7770050`

Added

obsolete N6-isopentenyl-AMP deaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/30800”^^anyURI
obsolete N6-isopentenyl-AMP deaminase activity creation date “2026-02-09T05:59:37Z”
obsolete N6-isopentenyl-AMP deaminase activity has_obo_namespace “molecular_function”
obsolete N6-isopentenyl-AMP deaminase activity label “obsolete N6-isopentenyl-AMP deaminase activity”
obsolete N6-isopentenyl-AMP deaminase activity id “GO:7770050”
obsolete N6-isopentenyl-AMP deaminase activity definition “OBSOLETE. Catalysis of the reaction: H2O + H+ + N6-isopentenyl-AMP = IMP + dimethylallylamine.”
- database_cross_reference “PMID:40840445”
obsolete N6-isopentenyl-AMP deaminase activity created by “dragon-ai-agent”
obsolete N6-isopentenyl-AMP deaminase activity comment “The reason for obsoletion is that this term was added in error.”
obsolete N6-isopentenyl-AMP deaminase activity deprecated true
Class: obsolete N6-isopentenyl-AMP deaminase activity

obsolete N6-isopentenyladenosine kinase activity `http://purl.obolibrary.org/obo/GO_7770048`

Added

obsolete N6-isopentenyladenosine kinase activity label “obsolete N6-isopentenyladenosine kinase activity”
obsolete N6-isopentenyladenosine kinase activity has_obo_namespace “molecular_function”
obsolete N6-isopentenyladenosine kinase activity created by “dragon-ai-agent”
obsolete N6-isopentenyladenosine kinase activity deprecated true
obsolete N6-isopentenyladenosine kinase activity comment “The reason for obsoletion is that this term was added in error.”
obsolete N6-isopentenyladenosine kinase activity term tracker item “https://github.com/geneontology/go-ontology/issues/30800”^^anyURI
obsolete N6-isopentenyladenosine kinase activity definition “OBSOLETE. Catalysis of the reaction: ATP + N6-isopentenyladenosine = ADP + H+ + N6-isopentenyl-AMP.”
- database_cross_reference “PMID:40840445”
obsolete N6-isopentenyladenosine kinase activity id “GO:7770048”
obsolete N6-isopentenyladenosine kinase activity creation date “2026-02-09T05:59:37Z”
Class: obsolete N6-isopentenyladenosine kinase activity

obsolete N6-methyladenosine kinase activity `http://purl.obolibrary.org/obo/GO_7770046`

Added

obsolete N6-methyladenosine kinase activity deprecated true
obsolete N6-methyladenosine kinase activity term tracker item “https://github.com/geneontology/go-ontology/issues/30800”^^anyURI
obsolete N6-methyladenosine kinase activity has_obo_namespace “molecular_function”
obsolete N6-methyladenosine kinase activity created by “dragon-ai-agent”
obsolete N6-methyladenosine kinase activity comment “The reason for obsoletion is that this term was added in error.”
obsolete N6-methyladenosine kinase activity definition “OBSOLETE. Catalysis of the reaction: ATP + N6-methyladenosine = ADP + H+ + N6-methyl-AMP.”
- database_cross_reference “PMID:40840445”
obsolete N6-methyladenosine kinase activity creation date “2026-02-09T05:59:37Z”
obsolete N6-methyladenosine kinase activity id “GO:7770046”
obsolete N6-methyladenosine kinase activity label “obsolete N6-methyladenosine kinase activity”
Class: obsolete N6-methyladenosine kinase activity

obsolete NAD biosynthesis via nicotinamide riboside salvage pathway `http://purl.obolibrary.org/obo/GO_0034356`

Removed

obsolete NAD biosynthesis via nicotinamide riboside salvage pathway database_cross_reference “MetaCyc:PWY3O-4106”
obsolete NAD biosynthesis via nicotinamide riboside salvage pathway database_cross_reference “Reactome:R-HSA-197264”
- label “Nicotinamide salvaging”

obsolete NADPHX epimerase activity `http://purl.obolibrary.org/obo/GO_0052857`

Removed

obsolete NADPHX epimerase activity database_cross_reference “Reactome:R-HSA-6806966”
- label “APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX”

obsolete Neu/ErbB-2 receptor activity `http://purl.obolibrary.org/obo/GO_0005012`

Removed

obsolete Neu/ErbB-2 receptor activity definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete Neu/ErbB-2 receptor activity definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete P-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0051994`

Removed

obsolete P-methyltransferase activity definition “Catalysis of the transfer of a methyl group to the phosphorus atom of an acceptor molecule.”
- database_cross_reference “GOC:ai”
obsolete P-methyltransferase activity label “P-methyltransferase activity”
obsolete P-methyltransferase activity SubClassOf methyltransferase activity

Added

obsolete P-methyltransferase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete P-methyltransferase activity definition “OBSOLETE. Catalysis of the transfer of a methyl group to the phosphorus atom of an acceptor molecule.”
- database_cross_reference “GOC:ai”
obsolete P-methyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete P-methyltransferase activity label “obsolete P-methyltransferase activity”
obsolete P-methyltransferase activity deprecated true

obsolete RNA polymerase II activity `http://purl.obolibrary.org/obo/GO_0001055`

Removed

obsolete RNA polymerase II activity database_cross_reference “Reactome:R-HSA-6814549”
- label “Pre-snRNA transcript initiation, Integrator binding, LEC binding”
obsolete RNA polymerase II activity database_cross_reference “Reactome:R-HSA-6814559”
- label “Pre-snRNA is elongated and capped with 7-methylguanosine”

obsolete RNA polymerase II complex recruiting activity `http://purl.obolibrary.org/obo/GO_0001139`

Removed

obsolete RNA polymerase II complex recruiting activity label “RNA polymerase II complex recruiting activity”
obsolete RNA polymerase II complex recruiting activity definition “Binding to an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.”
- database_cross_reference “PMID:16858867”
- database_cross_reference “GOC:txnOH”
obsolete RNA polymerase II complex recruiting activity SubClassOf protein-macromolecule adaptor activity
obsolete RNA polymerase II complex recruiting activity SubClassOf part of some RNA polymerase II preinitiation complex assembly
obsolete RNA polymerase II complex recruiting activity SubClassOf RNA polymerase II complex binding

Added

obsolete RNA polymerase II complex recruiting activity deprecated true
obsolete RNA polymerase II complex recruiting activity comment “This term was obsoleted because it is now represented by transcription coactivator activity ; GO:0003713.”
obsolete RNA polymerase II complex recruiting activity term replaced by transcription coactivator activity
obsolete RNA polymerase II complex recruiting activity label “obsolete RNA polymerase II complex recruiting activity”
obsolete RNA polymerase II complex recruiting activity term tracker item “https://github.com/geneontology/go-ontology/issues/31456”^^anyURI
obsolete RNA polymerase II complex recruiting activity definition “OBSOLETE. Binding to an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.”
- database_cross_reference “PMID:16858867”
- database_cross_reference “GOC:txnOH”

obsolete RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity `http://purl.obolibrary.org/obo/GO_0001010`

Removed

obsolete RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity definition “The function of binding to a specific DNA sequence and recruiting another transcription factor to the DNA in order to modulate transcription. The recruited factor may bind DNA directly, or may be colocalized via protein-protein interactions.”
- database_cross_reference “GOC:txnOH”
obsolete RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity label “RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity”
obsolete RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity SubClassOf protein-macromolecule adaptor activity
obsolete RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity SubClassOf has part some RNA polymerase II-specific DNA-binding transcription factor binding

Added

obsolete RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity consider transcription coregulator activity
obsolete RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity deprecated true
obsolete RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity comment “This term was obsoleted because it was not clearly defined.”
obsolete RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity term tracker item “https://github.com/geneontology/go-ontology/issues/31456”^^anyURI
obsolete RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity label “obsolete RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity”
obsolete RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity consider chromatin-protein adaptor activity
obsolete RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity definition “OBSOLETE. The function of binding to a specific DNA sequence and recruiting another transcription factor to the DNA in order to modulate transcription. The recruited factor may bind DNA directly, or may be colocalized via protein-protein interactions.”
- database_cross_reference “GOC:txnOH”

obsolete RNA polymerase III activity `http://purl.obolibrary.org/obo/GO_0001056`

Removed

obsolete RNA polymerase III activity database_cross_reference “Reactome:R-HSA-1964482”
- label “RNA polymerase III transcribes microbial dsDNA to dsRNA”

obsolete S-adenosylhomocysteine catabolic process `http://purl.obolibrary.org/obo/GO_0019510`

Removed

obsolete S-adenosylhomocysteine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of S-adenosylhomocysteine, forming homocysteine and then methionine.”
- database_cross_reference “ISBN:0198506732”
obsolete S-adenosylhomocysteine catabolic process label “S-adenosylhomocysteine catabolic process”
obsolete S-adenosylhomocysteine catabolic process SubClassOf modified amino acid catabolic process
obsolete S-adenosylhomocysteine catabolic process SubClassOf L-amino acid catabolic process
obsolete S-adenosylhomocysteine catabolic process SubClassOf sulfur compound catabolic process
obsolete S-adenosylhomocysteine catabolic process SubClassOf obsolete S-adenosylhomocysteine metabolic process
obsolete S-adenosylhomocysteine catabolic process SubClassOf purine ribonucleoside catabolic process
obsolete S-adenosylhomocysteine catabolic process SubClassOf non-proteinogenic amino acid catabolic process

Added

obsolete S-adenosylhomocysteine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/15179”^^anyURI
obsolete S-adenosylhomocysteine catabolic process deprecated true
obsolete S-adenosylhomocysteine catabolic process comment “The reason for obsoletion is that the terms represent molecular functions and not biological processes.”
obsolete S-adenosylhomocysteine catabolic process label “obsolete S-adenosylhomocysteine catabolic process”
obsolete S-adenosylhomocysteine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of S-adenosylhomocysteine, forming homocysteine and then methionine.”
- database_cross_reference “ISBN:0198506732”

obsolete S-adenosylhomocysteine metabolic process `http://purl.obolibrary.org/obo/GO_0046498`

Removed

obsolete S-adenosylhomocysteine metabolic process label “S-adenosylhomocysteine metabolic process”
obsolete S-adenosylhomocysteine metabolic process definition “The chemical reactions and pathways involving S-adenosylhomocysteine; the L-enantiomer is formed from S-adenosylmethionine and is a strong inhibitor of S-adenosylmethionine-mediated methylation reactions. It can be cleaved to form adenosine and homocysteine.”
- database_cross_reference “ISBN:0198506732”
obsolete S-adenosylhomocysteine metabolic process SubClassOf modified amino acid metabolic process
obsolete S-adenosylhomocysteine metabolic process SubClassOf L-amino acid metabolic process
obsolete S-adenosylhomocysteine metabolic process SubClassOf sulfur compound metabolic process
obsolete S-adenosylhomocysteine metabolic process SubClassOf non-proteinogenic amino acid metabolic process
obsolete S-adenosylhomocysteine metabolic process SubClassOf purine ribonucleoside metabolic process

Added

obsolete S-adenosylhomocysteine metabolic process comment “The reason for obsoletion is that the terms represent molecular functions and not biological processes.”
obsolete S-adenosylhomocysteine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/15179”^^anyURI
obsolete S-adenosylhomocysteine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving S-adenosylhomocysteine; the L-enantiomer is formed from S-adenosylmethionine and is a strong inhibitor of S-adenosylmethionine-mediated methylation reactions. It can be cleaved to form adenosine and homocysteine.”
- database_cross_reference “ISBN:0198506732”
obsolete S-adenosylhomocysteine metabolic process deprecated true
obsolete S-adenosylhomocysteine metabolic process label “obsolete S-adenosylhomocysteine metabolic process”

obsolete TRAIL receptor 1 biosynthetic process `http://purl.obolibrary.org/obo/GO_0045558`

Removed

obsolete TRAIL receptor 1 biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of TRAIL-R1 (TNF-related apoptosis inducing ligand receptor 1), which engages a caspase-dependent apoptotic pathway.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:9311998”

Added

obsolete TRAIL receptor 1 biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of TRAIL-R1 (TNF-related apoptosis inducing ligand receptor 1), which engages a caspase-dependent apoptotic pathway.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:9311998”

obsolete TRAIL receptor 2 biosynthetic process `http://purl.obolibrary.org/obo/GO_0045559`

Removed

obsolete TRAIL receptor 2 biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of TRAIL-R2 (TNF-related apoptosis inducing ligand receptor 2), which engages a caspase-dependent apoptotic pathway and mediates apoptosis via the intracellular adaptor molecule FADD/MORT1.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:9311998”

Added

obsolete TRAIL receptor 2 biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of TRAIL-R2 (TNF-related apoptosis inducing ligand receptor 2), which engages a caspase-dependent apoptotic pathway and mediates apoptosis via the intracellular adaptor molecule FADD/MORT1.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:9311998”

obsolete TRAIL receptor biosynthetic process `http://purl.obolibrary.org/obo/GO_0045557`

Removed

obsolete TRAIL receptor biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor.”
- database_cross_reference “GOC:go_curators”

Added

obsolete TRAIL receptor biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor.”
- database_cross_reference “GOC:curators”

obsolete UMP/dUMP kinase activity `http://purl.obolibrary.org/obo/GO_0009041`

Removed

obsolete UMP/dUMP kinase activity definition “OBSOLETE. Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP.”
- database_cross_reference “GOC:go_curators”

Added

obsolete UMP/dUMP kinase activity definition “OBSOLETE. Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP.”
- database_cross_reference “GOC:curators”

obsolete X-Pro dipeptidyl-peptidase activity `http://purl.obolibrary.org/obo/GO_0017088`

Removed

obsolete X-Pro dipeptidyl-peptidase activity definition “OBSOLETE. Catalysis of the hydrolysis of the terminal bond of Xaa-Pro-Xaa motifs to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-para-nitroanilide and (sequentially, at the second, fourth and sixth bonds) of the motif Tyr-Pro-Phe-Pro-Gly-Pro-Ile.”
- database_cross_reference “GOC:curator”

Added

obsolete X-Pro dipeptidyl-peptidase activity definition “OBSOLETE. Catalysis of the hydrolysis of the terminal bond of Xaa-Pro-Xaa motifs to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-para-nitroanilide and (sequentially, at the second, fourth and sixth bonds) of the motif Tyr-Pro-Phe-Pro-Gly-Pro-Ile.”
- database_cross_reference “GOC:curators”

obsolete acetyl-CoA biosynthetic process from acetate `http://purl.obolibrary.org/obo/GO_0019427`

Removed

obsolete acetyl-CoA biosynthetic process from acetate label “acetyl-CoA biosynthetic process from acetate”
obsolete acetyl-CoA biosynthetic process from acetate database_cross_reference “MetaCyc:ACETATEUTIL-PWY”
obsolete acetyl-CoA biosynthetic process from acetate definition “The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate.”
- database_cross_reference “MetaCyc:ACETATEUTIL-PWY”
obsolete acetyl-CoA biosynthetic process from acetate SubClassOf acetyl-CoA biosynthetic process
obsolete acetyl-CoA biosynthetic process from acetate SubClassOf acetate metabolic process

Added

obsolete acetyl-CoA biosynthetic process from acetate term tracker item “https://github.com/geneontology/go-ontology/issues/31666”^^anyURI
obsolete acetyl-CoA biosynthetic process from acetate deprecated true
obsolete acetyl-CoA biosynthetic process from acetate term replaced by acetyl-CoA biosynthetic process
obsolete acetyl-CoA biosynthetic process from acetate definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate.”
- database_cross_reference “MetaCyc:ACETATEUTIL-PWY”
obsolete acetyl-CoA biosynthetic process from acetate label “obsolete acetyl-CoA biosynthetic process from acetate”
obsolete acetyl-CoA biosynthetic process from acetate comment “The reason for obsoletion is that this term represents a GO-CAM.”

obsolete acetyl-CoA biosynthetic process from ethanol `http://purl.obolibrary.org/obo/GO_0019431`

Removed

obsolete acetyl-CoA biosynthetic process from ethanol database_cross_reference “MetaCyc:PWY66-162”
obsolete acetyl-CoA biosynthetic process from ethanol narrowMatch ETOH-ACETYLCOA-ANA-PWY
obsolete acetyl-CoA biosynthetic process from ethanol label “acetyl-CoA biosynthetic process from ethanol”
obsolete acetyl-CoA biosynthetic process from ethanol database_cross_reference “MetaCyc:ETOH-ACETYLCOA-ANA-PWY”
obsolete acetyl-CoA biosynthetic process from ethanol definition “The chemical reactions and pathways resulting in the formation of acetyl-CoA from ethanol via acetaldehyde.”
- database_cross_reference “GOC:go_curators”
obsolete acetyl-CoA biosynthetic process from ethanol database_cross_reference “MetaCyc:PWY66-21”
obsolete acetyl-CoA biosynthetic process from ethanol narrowMatch PWY66-161
obsolete acetyl-CoA biosynthetic process from ethanol narrowMatch PWY66-162
obsolete acetyl-CoA biosynthetic process from ethanol database_cross_reference “MetaCyc:PWY66-161”
obsolete acetyl-CoA biosynthetic process from ethanol narrowMatch PWY66-21
obsolete acetyl-CoA biosynthetic process from ethanol SubClassOf generation of precursor metabolites and energy
obsolete acetyl-CoA biosynthetic process from ethanol SubClassOf ethanol metabolic process
obsolete acetyl-CoA biosynthetic process from ethanol SubClassOf acetyl-CoA biosynthetic process

Added

obsolete acetyl-CoA biosynthetic process from ethanol comment “The reason for obsoletion is that this term represents a GO-CAM.”
obsolete acetyl-CoA biosynthetic process from ethanol definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of acetyl-CoA from ethanol via acetaldehyde.”
- database_cross_reference “GOC:curators”
obsolete acetyl-CoA biosynthetic process from ethanol term replaced by acetyl-CoA biosynthetic process
obsolete acetyl-CoA biosynthetic process from ethanol deprecated true
obsolete acetyl-CoA biosynthetic process from ethanol term tracker item “https://github.com/geneontology/go-ontology/issues/31666”^^anyURI
obsolete acetyl-CoA biosynthetic process from ethanol label “obsolete acetyl-CoA biosynthetic process from ethanol”

obsolete acetyl-CoA biosynthetic process from pantothenate `http://purl.obolibrary.org/obo/GO_1990181`

Removed

obsolete acetyl-CoA biosynthetic process from pantothenate label “acetyl-CoA biosynthetic process from pantothenate”
obsolete acetyl-CoA biosynthetic process from pantothenate definition “The chemical reactions and pathways resulting in the formation of acetyl-CoA from pantothenate via phosphopantothenate and CoA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:23091701”
obsolete acetyl-CoA biosynthetic process from pantothenate SubClassOf pantothenate metabolic process
obsolete acetyl-CoA biosynthetic process from pantothenate SubClassOf acetyl-CoA biosynthetic process

Added

obsolete acetyl-CoA biosynthetic process from pantothenate term tracker item “https://github.com/geneontology/go-ontology/issues/31666”^^anyURI
obsolete acetyl-CoA biosynthetic process from pantothenate deprecated true
obsolete acetyl-CoA biosynthetic process from pantothenate comment “The reason for obsoletion is that these represent GO-CAMs.”
obsolete acetyl-CoA biosynthetic process from pantothenate term replaced by acetyl-CoA biosynthetic process
obsolete acetyl-CoA biosynthetic process from pantothenate definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of acetyl-CoA from pantothenate via phosphopantothenate and CoA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:23091701”
obsolete acetyl-CoA biosynthetic process from pantothenate label “obsolete acetyl-CoA biosynthetic process from pantothenate”

obsolete acetylated low-density lipoprotein catabolic process `http://purl.obolibrary.org/obo/GO_0045193`

Removed

obsolete acetylated low-density lipoprotein catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of acetylated low-density lipoproteins.”
- database_cross_reference “GOC:go_curators”

Added

obsolete acetylated low-density lipoprotein catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of acetylated low-density lipoproteins.”
- database_cross_reference “GOC:curators”

obsolete acetyldiaminopimelate:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0043760`

Removed

obsolete acetyldiaminopimelate:2-oxoglutarate transaminase activity label “acetyldiaminopimelate aminotransferase activity”
obsolete acetyldiaminopimelate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: N-acetyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-acetyl-2-L-amino-6-oxoheptanedioate + L-glutamate.”
- database_cross_reference “PMID:1906065”
obsolete acetyldiaminopimelate:2-oxoglutarate transaminase activity SubClassOf transaminase activity

Added

obsolete acetyldiaminopimelate:2-oxoglutarate transaminase activity consider succinyldiaminopimelate:2-oxoglutarate transaminase activity
obsolete acetyldiaminopimelate:2-oxoglutarate transaminase activity definition “OBSOLETE. Catalysis of the reaction: N-acetyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-acetyl-2-L-amino-6-oxoheptanedioate + L-glutamate.”
- database_cross_reference “PMID:1906065”
obsolete acetyldiaminopimelate:2-oxoglutarate transaminase activity label “obsolete acetyldiaminopimelate:2-oxoglutarate transaminase activity”
obsolete acetyldiaminopimelate:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
obsolete acetyldiaminopimelate:2-oxoglutarate transaminase activity deprecated true
obsolete acetyldiaminopimelate:2-oxoglutarate transaminase activity comment “This term was obsoleted because there is no evidence that this reaction exists. This was an alternative succinyldiaminopimelate aminotransferase substrate tested in PMID:1906065.”
obsolete acetyldiaminopimelate:2-oxoglutarate transaminase activity has_broad_synonym “acetyldiaminopimelate aminotransferase activity”

obsolete activation of cysteine-type endopeptidase activity involved in apoptotic process `http://purl.obolibrary.org/obo/GO_0006919`

Removed

obsolete activation of cysteine-type endopeptidase activity involved in apoptotic process database_cross_reference “Reactome:R-HSA-69416”
- label “Dimerization of procaspase-8”

obsolete activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c `http://purl.obolibrary.org/obo/GO_0008635`

Removed

obsolete activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c database_cross_reference “Reactome:R-HSA-111459”
- label “Activation of caspases through apoptosome-mediated cleavage”

obsolete activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway `http://purl.obolibrary.org/obo/GO_0097296`

Removed

obsolete activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway database_cross_reference “Reactome:R-HSA-140534”
- label “Caspase activation via Death Receptors in the presence of ligand”

obsolete activation of the inhibitor of kappa kinase `http://purl.obolibrary.org/obo/GO_0007251`

Removed

obsolete activation of the inhibitor of kappa kinase definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete activation of the inhibitor of kappa kinase definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete actomyosin, actin portion `http://purl.obolibrary.org/obo/GO_0042643`

Removed

obsolete actomyosin, actin portion definition “OBSOLETE. The actin part of any complex of actin, myosin, and accessory proteins.”
- database_cross_reference “GOC:go_curators”

Added

obsolete actomyosin, actin portion definition “OBSOLETE. The actin part of any complex of actin, myosin, and accessory proteins.”
- database_cross_reference “GOC:curators”

obsolete acyl-carrier-protein biosynthetic process `http://purl.obolibrary.org/obo/GO_0042967`

Removed

obsolete acyl-carrier-protein biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of acyl-carrier protein.”
- database_cross_reference “GOC:go_curators”

Added

obsolete acyl-carrier-protein biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of acyl-carrier protein.”
- database_cross_reference “GOC:curators”

obsolete adult eye photoreceptor development (sensu Drosophila) `http://purl.obolibrary.org/obo/GO_0001753`

Removed

obsolete adult eye photoreceptor development (sensu Drosophila) definition “OBSOLETE. Development of a photoreceptor, a receptor that responds to light, in the adult Drosophila eye.”
- database_cross_reference “GOC:go_curators”

Added

obsolete adult eye photoreceptor development (sensu Drosophila) definition “OBSOLETE. Development of a photoreceptor, a receptor that responds to light, in the adult Drosophila eye.”
- database_cross_reference “GOC:curators”

obsolete adult feeding behavior (sensu Insecta) `http://purl.obolibrary.org/obo/GO_0030535`

Removed

obsolete adult feeding behavior (sensu Insecta) definition “OBSOLETE. Feeding behavior in a fully developed and mature organism, as described in insects.”
- database_cross_reference “GOC:jid”
- database_cross_reference “GOC:go_curators”

Added

obsolete adult feeding behavior (sensu Insecta) definition “OBSOLETE. Feeding behavior in a fully developed and mature organism, as described in insects.”
- database_cross_reference “GOC:jid”
- database_cross_reference “GOC:curators”

obsolete age dependent accumulation of genetic damage `http://purl.obolibrary.org/obo/GO_0007570`

Removed

obsolete age dependent accumulation of genetic damage definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete age dependent accumulation of genetic damage definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete age dependent decreased translational activity `http://purl.obolibrary.org/obo/GO_0007572`

Removed

obsolete age dependent decreased translational activity definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete age dependent decreased translational activity definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete age dependent increased protein content `http://purl.obolibrary.org/obo/GO_0007573`

Removed

obsolete age dependent increased protein content definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete age dependent increased protein content definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete alanine catabolic process `http://purl.obolibrary.org/obo/GO_0006524`

Removed

obsolete alanine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of alanine, 2-aminopropanoic acid.”
- database_cross_reference “GOC:go_curators”

Added

obsolete alanine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of alanine, 2-aminopropanoic acid.”
- database_cross_reference “GOC:curators”

obsolete alanine metabolic process `http://purl.obolibrary.org/obo/GO_0006522`

Removed

obsolete alanine metabolic process label “alanine metabolic process”
obsolete alanine metabolic process definition “The chemical reactions and pathways involving alanine, 2-aminopropanoic acid.”
- database_cross_reference “GOC:go_curators”
obsolete alanine metabolic process SubClassOf alpha-amino acid metabolic process

Added

obsolete alanine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI
obsolete alanine metabolic process deprecated true
obsolete alanine metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
obsolete alanine metabolic process consider L-alanine biosynthetic process
obsolete alanine metabolic process consider L-alanine catabolic process
obsolete alanine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving alanine, 2-aminopropanoic acid.”
- database_cross_reference “GOC:curators”
obsolete alanine metabolic process label “obsolete alanine metabolic process”

obsolete aldo-keto reductase (NADPH) activity `http://purl.obolibrary.org/obo/GO_0004033`

Removed

obsolete aldo-keto reductase (NADPH) activity database_cross_reference “Reactome:R-HSA-192036”
- label “5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol”
obsolete aldo-keto reductase (NADPH) activity database_cross_reference “Reactome:R-HSA-9027600”
- label “Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3”
obsolete aldo-keto reductase (NADPH) activity database_cross_reference “Reactome:R-HSA-5692232”
- label “AKR1A1 oxidises BaPtDHD to BaP-7,8-dione”
obsolete aldo-keto reductase (NADPH) activity database_cross_reference “Reactome:R-HSA-193746”
- label “4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one”
obsolete aldo-keto reductase (NADPH) activity database_cross_reference “Reactome:R-HSA-193821”
- label “4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one”
obsolete aldo-keto reductase (NADPH) activity database_cross_reference “Reactome:R-HSA-193755”
- label “4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one”
obsolete aldo-keto reductase (NADPH) activity database_cross_reference “Reactome:R-HSA-193800”
- label “5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol”
obsolete aldo-keto reductase (NADPH) activity database_cross_reference “Reactome:R-HSA-192067”
- label “4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one”
obsolete aldo-keto reductase (NADPH) activity database_cross_reference “Reactome:R-HSA-192033”
- label “4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one”
obsolete aldo-keto reductase (NADPH) activity database_cross_reference “Reactome:R-HSA-198845”
- label “CYB5A:heme reduces Asc.- to AscH-“
obsolete aldo-keto reductase (NADPH) activity database_cross_reference “Reactome:R-HSA-2855252”
- label “AKRs reduce RBP2:atRAL to RBP2:atROL”
obsolete aldo-keto reductase (NADPH) activity database_cross_reference “Reactome:R-HSA-9027531”
- label “Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA”
obsolete aldo-keto reductase (NADPH) activity database_cross_reference “Reactome:R-HSA-9027598”
- label “Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3”
obsolete aldo-keto reductase (NADPH) activity database_cross_reference “Reactome:R-HSA-193841”
- label “5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol”
obsolete aldo-keto reductase (NADPH) activity database_cross_reference “Reactome:R-HSA-5423637”
- label “AKR dimers reduce AFBDHO to AFBDOH”
obsolete aldo-keto reductase (NADPH) activity database_cross_reference “Reactome:R-HSA-193781”
- label “5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol”
obsolete aldo-keto reductase (NADPH) activity database_cross_reference “Reactome:R-HSA-193824”
- label “4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one”
obsolete aldo-keto reductase (NADPH) activity database_cross_reference “Reactome:R-HSA-193758”
- label “5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol”
obsolete aldo-keto reductase (NADPH) activity database_cross_reference “Reactome:R-HSA-9027562”
- label “Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA”
obsolete aldo-keto reductase (NADPH) activity database_cross_reference “Reactome:R-HSA-192160”
- label “5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol”

obsolete allantoin/allantoate transport `http://purl.obolibrary.org/obo/GO_0006838`

Removed

obsolete allantoin/allantoate transport definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete allantoin/allantoate transport definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete amino-terminal vacuolar sorting propeptide binding `http://purl.obolibrary.org/obo/GO_0009940`

Removed

obsolete amino-terminal vacuolar sorting propeptide binding definition “Binding to an amino terminal propeptide, which functions as a sorting signal to sort away the soluble vacuolar protein from Golgi to lytic vacuole via clathrin-coated vesicles.”
- database_cross_reference “PMID:10871276”
- database_cross_reference “GOC:sm”
obsolete amino-terminal vacuolar sorting propeptide binding label “amino-terminal vacuolar sorting propeptide binding”
obsolete amino-terminal vacuolar sorting propeptide binding SubClassOf vacuolar sorting signal receptor activity

Added

obsolete amino-terminal vacuolar sorting propeptide binding term replaced by vacuolar sorting signal receptor activity
obsolete amino-terminal vacuolar sorting propeptide binding term tracker item “https://github.com/geneontology/go-ontology/issues/31410”^^anyURI
obsolete amino-terminal vacuolar sorting propeptide binding comment “This term was obsolete because it is out of scope for GO; target regions of interactions are not captured.”
obsolete amino-terminal vacuolar sorting propeptide binding label “obsolete amino-terminal vacuolar sorting propeptide binding”
obsolete amino-terminal vacuolar sorting propeptide binding deprecated true
obsolete amino-terminal vacuolar sorting propeptide binding definition “OBSOLETE. Binding to an amino terminal propeptide, which functions as a sorting signal to sort away the soluble vacuolar protein from Golgi to lytic vacuole via clathrin-coated vesicles.”
- database_cross_reference “PMID:10871276”
- database_cross_reference “GOC:sm”

obsolete ammelide aminohydrolase activity `http://purl.obolibrary.org/obo/GO_0018754`

Removed

obsolete ammelide aminohydrolase activity definition “Catalysis of the reaction: ammelide + H2O = cyanuric acid + NH3.”
- database_cross_reference “PMID:1991731”
obsolete ammelide aminohydrolase activity label “ammelide aminohydrolase activity”
obsolete ammelide aminohydrolase activity SubClassOf hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

Added

obsolete ammelide aminohydrolase activity definition “OBSOLETE. Catalysis of the reaction: ammelide + H2O = cyanuric acid + NH4+.”
- database_cross_reference “PMID:1991731”
obsolete ammelide aminohydrolase activity label “obsolete ammelide aminohydrolase activity”
obsolete ammelide aminohydrolase activity deprecated true
obsolete ammelide aminohydrolase activity comment “This term was obsoleted because there is no evidence that this reaction exists.”
obsolete ammelide aminohydrolase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31530”^^anyURI

obsolete anaerobic 2-aminobenzoate metabolic process `http://purl.obolibrary.org/obo/GO_0018870`

Removed

obsolete anaerobic 2-aminobenzoate metabolic process definition “The chemical reactions and pathways resulting in the breakdown of 2-aminobenzoate, a derivative of benzoic acid with an NH2 group attached to C2, that occurs in the absence of oxygen.”
- database_cross_reference “GOC:ai”
obsolete anaerobic 2-aminobenzoate metabolic process label “anaerobic 2-aminobenzoate metabolic process”
obsolete anaerobic 2-aminobenzoate metabolic process database_cross_reference “UM-BBD_pathwayID:abz”
obsolete anaerobic 2-aminobenzoate metabolic process has_exact_synonym “anaerobic 2-aminobenzoate metabolism”
obsolete anaerobic 2-aminobenzoate metabolic process SubClassOf obsolete anthranilate metabolic process

Added

obsolete anaerobic 2-aminobenzoate metabolic process has_broad_synonym “anaerobic 2-aminobenzoate metabolism”
obsolete anaerobic 2-aminobenzoate metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
obsolete anaerobic 2-aminobenzoate metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI
obsolete anaerobic 2-aminobenzoate metabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of 2-aminobenzoate, a derivative of benzoic acid with an NH2 group attached to C2, that occurs in the absence of oxygen.”
- database_cross_reference “GOC:curators”
obsolete anaerobic 2-aminobenzoate metabolic process has_broad_synonym “anthranilate catabolic process”
obsolete anaerobic 2-aminobenzoate metabolic process deprecated true
obsolete anaerobic 2-aminobenzoate metabolic process consider anthranilate catabolic process
obsolete anaerobic 2-aminobenzoate metabolic process label “obsolete anaerobic 2-aminobenzoate metabolic process”

obsolete anaerobic rhamnose catabolic process `http://purl.obolibrary.org/obo/GO_0019304`

Removed

obsolete anaerobic rhamnose catabolic process definition “The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose, that occurs in the absence of oxygen.”
- database_cross_reference “GOC:ai”
obsolete anaerobic rhamnose catabolic process has_exact_synonym “anaerobic rhamnose breakdown”
obsolete anaerobic rhamnose catabolic process label “anaerobic rhamnose catabolic process”
obsolete anaerobic rhamnose catabolic process has_exact_synonym “anaerobic rhamnose catabolism”
obsolete anaerobic rhamnose catabolic process has_exact_synonym “anaerobic rhamnose degradation”
obsolete anaerobic rhamnose catabolic process SubClassOf rhamnose catabolic process

Added

obsolete anaerobic rhamnose catabolic process deprecated true
obsolete anaerobic rhamnose catabolic process label “obsolete anaerobic rhamnose catabolic process”
obsolete anaerobic rhamnose catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31652”^^anyURI
obsolete anaerobic rhamnose catabolic process comment “The reason for obsoletion is that this term lacks annotations or supporting evidence, and the MetaCyc pathways for L-rhamnose degradation are not described as anaerobic.”
obsolete anaerobic rhamnose catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose, that occurs in the absence of oxygen.”
- database_cross_reference “GOC:ai”
obsolete anaerobic rhamnose catabolic process term replaced by rhamnose catabolic process

obsolete anthranilate metabolic process `http://purl.obolibrary.org/obo/GO_0043420`

Removed

obsolete anthranilate metabolic process label “anthranilate metabolic process”
obsolete anthranilate metabolic process definition “The chemical reactions and pathways involving anthranilate (2-aminobenzoate).”
- database_cross_reference “GOC:jl”
obsolete anthranilate metabolic process database_cross_reference “UM-BBD_pathwayID:abz2”
obsolete anthranilate metabolic process SubClassOf benzene-containing compound metabolic process
obsolete anthranilate metabolic process SubClassOf aromatic amino acid metabolic process
obsolete anthranilate metabolic process SubClassOf monocarboxylic acid metabolic process

Added

obsolete anthranilate metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
obsolete anthranilate metabolic process deprecated true
obsolete anthranilate metabolic process definition “OBSOLETE. The chemical reactions and pathways involving anthranilate (2-aminobenzoate).”
- database_cross_reference “GOC:jl”
obsolete anthranilate metabolic process has_broad_synonym “anthranilate catabolic process”
obsolete anthranilate metabolic process label “obsolete anthranilate metabolic process”
obsolete anthranilate metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI

obsolete antibacterial peptide activity `http://purl.obolibrary.org/obo/GO_0003797`

Removed

obsolete antibacterial peptide activity definition “OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells.”
- database_cross_reference “GOC:go_curators”

Added

obsolete antibacterial peptide activity definition “OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells.”
- database_cross_reference “GOC:curators”

obsolete antibiotic susceptibility/resistance `http://purl.obolibrary.org/obo/GO_0017141`

Removed

obsolete antibiotic susceptibility/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete antibiotic susceptibility/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete antifungal peptide activity `http://purl.obolibrary.org/obo/GO_0003799`

Removed

obsolete antifungal peptide activity definition “OBSOLETE. Inhibits the growth of, or directly kills, fungal cells.”
- database_cross_reference “GOC:go_curators”

Added

obsolete antifungal peptide activity definition “OBSOLETE. Inhibits the growth of, or directly kills, fungal cells.”
- database_cross_reference “GOC:curators”

obsolete antimicrobial peptide activity `http://purl.obolibrary.org/obo/GO_0003795`

Removed

obsolete antimicrobial peptide activity definition “OBSOLETE. Inhibits the growth of, or directly kills, microbial cells.”
- database_cross_reference “GOC:go_curators”

Added

obsolete antimicrobial peptide activity definition “OBSOLETE. Inhibits the growth of, or directly kills, microbial cells.”
- database_cross_reference “GOC:curators”

obsolete arginine catabolic process to ornithine `http://purl.obolibrary.org/obo/GO_0019547`

Removed

obsolete arginine catabolic process to ornithine definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine.”
- database_cross_reference “GOC:go_curators”

Added

obsolete arginine catabolic process to ornithine definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine.”
- database_cross_reference “GOC:curators”

obsolete arginine catabolic process to spermine `http://purl.obolibrary.org/obo/GO_0019548`

Removed

obsolete arginine catabolic process to spermine definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including spermine.”
- database_cross_reference “GOC:go_curators”

Added

obsolete arginine catabolic process to spermine definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including spermine.”
- database_cross_reference “GOC:curators”

obsolete argininosuccinate metabolic process `http://purl.obolibrary.org/obo/GO_0000053`

Removed

obsolete argininosuccinate metabolic process definition “The chemical reactions and pathways involving argininosuccinate, 2-(N(omega)-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate.”
- database_cross_reference “ISBN:0198506732”
obsolete argininosuccinate metabolic process label “argininosuccinate metabolic process”
obsolete argininosuccinate metabolic process SubClassOf L-amino acid metabolic process
obsolete argininosuccinate metabolic process SubClassOf tricarboxylic acid metabolic process
obsolete argininosuccinate metabolic process SubClassOf modified amino acid metabolic process
obsolete argininosuccinate metabolic process SubClassOf non-proteinogenic amino acid metabolic process

Added

obsolete argininosuccinate metabolic process consider urea cycle
obsolete argininosuccinate metabolic process definition “OBSOLETE. The chemical reactions and pathways involving argininosuccinate, 2-(N(omega)-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate.”
- database_cross_reference “ISBN:0198506732”
obsolete argininosuccinate metabolic process comment “This term was obsoleted because it represents a pathway intermediate.”
obsolete argininosuccinate metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI
obsolete argininosuccinate metabolic process label “obsolete argininosuccinate metabolic process”
obsolete argininosuccinate metabolic process deprecated true

obsolete arsenate sensitivity/resistance `http://purl.obolibrary.org/obo/GO_0017139`

Removed

obsolete arsenate sensitivity/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete arsenate sensitivity/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete asparagine biosynthetic process `http://purl.obolibrary.org/obo/GO_0006529`

Removed

obsolete asparagine biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid.”
- database_cross_reference “GOC:go_curators”

Added

obsolete asparagine biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid.”
- database_cross_reference “GOC:curators”

obsolete aspartate family amino acid metabolic process `http://purl.obolibrary.org/obo/GO_0009066`

Removed

obsolete aspartate family amino acid metabolic process database_cross_reference “Reactome:R-HSA-8963693”
- label “Aspartate and asparagine metabolism”

obsolete aspartate transamidation `http://purl.obolibrary.org/obo/GO_0019465`

Removed

obsolete aspartate transamidation definition “OBSOLETE. The exchange of the amino group of aspartate, the anion derived from aspartic acid, for another amino group.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

obsolete aspartate transamidation definition “OBSOLETE. The exchange of the amino group of aspartate, the anion derived from aspartic acid, for another amino group.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

obsolete aspartyl aminopeptidase activity `http://purl.obolibrary.org/obo/GO_0042576`

Removed

obsolete aspartyl aminopeptidase activity definition “OBSOLETE. Catalysis of the release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.”
- database_cross_reference “GOC:curator”

Added

obsolete aspartyl aminopeptidase activity definition “OBSOLETE. Catalysis of the release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.”
- database_cross_reference “GOC:curators”

obsolete autophagic death (sensu Fungi) `http://purl.obolibrary.org/obo/GO_0030465`

Removed

obsolete autophagic death (sensu Fungi) definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete autophagic death (sensu Fungi) definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete bacteriocin susceptibility/resistance `http://purl.obolibrary.org/obo/GO_0019880`

Removed

obsolete bacteriocin susceptibility/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete bacteriocin susceptibility/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete basal RNA polymerase II transcription machinery binding `http://purl.obolibrary.org/obo/GO_0001099`

Removed

obsolete basal RNA polymerase II transcription machinery binding label “basal RNA polymerase II transcription machinery binding”
obsolete basal RNA polymerase II transcription machinery binding comment “Note that the definition of basal, or general, transcription factors has typically been done at a small number of well characterized activator-independent promoters. At an activator-dependent promoter, one or more additional factors are generally required in addition to the basal factors.”
obsolete basal RNA polymerase II transcription machinery binding definition “Binding to a component of the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase.”
- database_cross_reference “GOC:txnOH”
obsolete basal RNA polymerase II transcription machinery binding SubClassOf obsolete basal transcription machinery binding

Added

obsolete basal RNA polymerase II transcription machinery binding deprecated true
obsolete basal RNA polymerase II transcription machinery binding comment “This term was obsoleted because it is equivalent to RNA polymerase II complex binding ; GO:0000993.”
obsolete basal RNA polymerase II transcription machinery binding term tracker item “https://github.com/geneontology/go-ontology/issues/16062”^^anyURI
obsolete basal RNA polymerase II transcription machinery binding term replaced by RNA polymerase II complex binding
obsolete basal RNA polymerase II transcription machinery binding label “obsolete basal RNA polymerase II transcription machinery binding”
obsolete basal RNA polymerase II transcription machinery binding definition “OBSOLETE. Binding to a component of the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase.”
- database_cross_reference “GOC:txnOH”

obsolete basal transcription machinery binding `http://purl.obolibrary.org/obo/GO_0001098`

Removed

obsolete basal transcription machinery binding definition “Binding to a component of the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase.”
- database_cross_reference “GOC:txnOH”
obsolete basal transcription machinery binding comment “Note that the definition of basal, or general, transcription factors has typically been done at a small number of well characterized activator-independent promoters. At an activator-dependent promoter, one or more additional factors are generally required in addition to the basal factors.”
obsolete basal transcription machinery binding label “basal transcription machinery binding”
obsolete basal transcription machinery binding SubClassOf protein binding

Added

obsolete basal transcription machinery binding term tracker item “https://github.com/geneontology/go-ontology/issues/16062”^^anyURI
obsolete basal transcription machinery binding deprecated true
obsolete basal transcription machinery binding comment “This term was obsoleted because it is an unnecessary grouping term.”
obsolete basal transcription machinery binding label “obsolete basal transcription machinery binding”
obsolete basal transcription machinery binding definition “OBSOLETE. Binding to a component of the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase.”
- database_cross_reference “GOC:txnOH”

obsolete bent DNA binding `http://purl.obolibrary.org/obo/GO_0006326`

Removed

obsolete bent DNA binding definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete bent DNA binding definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete benzoyl acetate-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0018856`

Removed

obsolete benzoyl acetate-CoA ligase activity database_cross_reference “UM-BBD_reactionID:r0242”
obsolete benzoyl acetate-CoA ligase activity database_cross_reference “KEGG_REACTION:R05452”
obsolete benzoyl acetate-CoA ligase activity definition “Catalysis of the reaction: 3-oxo-3-phenylpropionate + CoA + ATP = AMP + diphosphate + benzoyl acetyl-CoA.”
- database_cross_reference “UM-BBD_reactionID:r0242”
obsolete benzoyl acetate-CoA ligase activity label “benzoyl acetate-CoA ligase activity”
obsolete benzoyl acetate-CoA ligase activity database_cross_reference “SABIO-RK:5058”
obsolete benzoyl acetate-CoA ligase activity SubClassOf CoA-ligase activity
obsolete benzoyl acetate-CoA ligase activity SubClassOf acid-thiol ligase activity

Added

obsolete benzoyl acetate-CoA ligase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete benzoyl acetate-CoA ligase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete benzoyl acetate-CoA ligase activity definition “OBSOLETE. Catalysis of the reaction: 3-oxo-3-phenylpropionate + CoA + ATP = AMP + diphosphate + benzoyl acetyl-CoA.”
- database_cross_reference “GOC:curators”
obsolete benzoyl acetate-CoA ligase activity deprecated true
obsolete benzoyl acetate-CoA ligase activity label “obsolete benzoyl acetate-CoA ligase activity”

obsolete benzoyl acetate-CoA thiolase activity `http://purl.obolibrary.org/obo/GO_0018711`

Removed

obsolete benzoyl acetate-CoA thiolase activity label “benzoyl acetate-CoA thiolase activity”
obsolete benzoyl acetate-CoA thiolase activity database_cross_reference “UM-BBD_reactionID:r0243”
obsolete benzoyl acetate-CoA thiolase activity definition “Catalysis of the reaction: benzoyl acetyl-CoA + CoA = acetyl-CoA + benzoyl-CoA.”
- database_cross_reference “UM-BBD_reactionID:r0243”
obsolete benzoyl acetate-CoA thiolase activity database_cross_reference “MetaCyc:RXN-2006”
obsolete benzoyl acetate-CoA thiolase activity SubClassOf acyltransferase activity, transferring groups other than amino-acyl groups

Added

obsolete benzoyl acetate-CoA thiolase activity deprecated true
obsolete benzoyl acetate-CoA thiolase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete benzoyl acetate-CoA thiolase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete benzoyl acetate-CoA thiolase activity definition “OBSOLETE. Catalysis of the reaction: benzoyl acetyl-CoA + CoA = acetyl-CoA + benzoyl-CoA.”
- database_cross_reference “GOC:curators”
obsolete benzoyl acetate-CoA thiolase activity label “obsolete benzoyl acetate-CoA thiolase activity”

obsolete beta-alanine biosynthetic process via 1,3 diaminopropane `http://purl.obolibrary.org/obo/GO_0033394`

Removed

obsolete beta-alanine biosynthetic process via 1,3 diaminopropane label “beta-alanine biosynthetic process via 1,3 diaminopropane”
obsolete beta-alanine biosynthetic process via 1,3 diaminopropane definition “The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 1,3 diaminopropane.”
- database_cross_reference “GOC:mah”
- database_cross_reference “MetaCyc:PWY-3981”
obsolete beta-alanine biosynthetic process via 1,3 diaminopropane database_cross_reference “MetaCyc:PWY-3981”
obsolete beta-alanine biosynthetic process via 1,3 diaminopropane SubClassOf beta-alanine biosynthetic process

Added

obsolete beta-alanine biosynthetic process via 1,3 diaminopropane deprecated true
obsolete beta-alanine biosynthetic process via 1,3 diaminopropane label “obsolete beta-alanine biosynthetic process via 1,3 diaminopropane”
obsolete beta-alanine biosynthetic process via 1,3 diaminopropane definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 1,3 diaminopropane.”
- database_cross_reference “GOC:mah”
obsolete beta-alanine biosynthetic process via 1,3 diaminopropane term replaced by beta-alanine biosynthetic process
obsolete beta-alanine biosynthetic process via 1,3 diaminopropane term tracker item “https://github.com/geneontology/go-ontology/issues/31510”^^anyURI
obsolete beta-alanine biosynthetic process via 1,3 diaminopropane comment “The reason for merging is that this term represents a GO-CAM model.”

obsolete beta-alanine biosynthetic process via 3-hydroxypropionate `http://purl.obolibrary.org/obo/GO_0033395`

Removed

obsolete beta-alanine biosynthetic process via 3-hydroxypropionate database_cross_reference “MetaCyc:PWY-3941”
obsolete beta-alanine biosynthetic process via 3-hydroxypropionate definition “The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 3-hydroxypropionate.”
- database_cross_reference “GOC:mah”
- database_cross_reference “MetaCyc:PWY-3941”
obsolete beta-alanine biosynthetic process via 3-hydroxypropionate label “beta-alanine biosynthetic process via 3-hydroxypropionate”
obsolete beta-alanine biosynthetic process via 3-hydroxypropionate SubClassOf beta-alanine biosynthetic process

Added

obsolete beta-alanine biosynthetic process via 3-hydroxypropionate label “obsolete beta-alanine biosynthetic process via 3-hydroxypropionate”
obsolete beta-alanine biosynthetic process via 3-hydroxypropionate comment “The reason for obsoletion is that this term represents a GO-CAM model.”
obsolete beta-alanine biosynthetic process via 3-hydroxypropionate term tracker item “https://github.com/geneontology/go-ontology/issues/31510”^^anyURI
obsolete beta-alanine biosynthetic process via 3-hydroxypropionate definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 3-hydroxypropionate.”
- database_cross_reference “GOC:mah”
obsolete beta-alanine biosynthetic process via 3-hydroxypropionate term replaced by beta-alanine biosynthetic process
obsolete beta-alanine biosynthetic process via 3-hydroxypropionate deprecated true

obsolete beta-alanine biosynthetic process via 3-ureidopropionate `http://purl.obolibrary.org/obo/GO_0033396`

Removed

obsolete beta-alanine biosynthetic process via 3-ureidopropionate definition “The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 3-ureidopropionate.”
- database_cross_reference “GOC:mah”
- database_cross_reference “MetaCyc:PWY-3982”
obsolete beta-alanine biosynthetic process via 3-ureidopropionate database_cross_reference “MetaCyc:PWY-3982”
obsolete beta-alanine biosynthetic process via 3-ureidopropionate label “beta-alanine biosynthetic process via 3-ureidopropionate”
obsolete beta-alanine biosynthetic process via 3-ureidopropionate SubClassOf beta-alanine biosynthetic process

Added

obsolete beta-alanine biosynthetic process via 3-ureidopropionate comment “The reason for obsoletion is that this term represents a GO-CAM model.”
obsolete beta-alanine biosynthetic process via 3-ureidopropionate label “obsolete beta-alanine biosynthetic process via 3-ureidopropionate”
obsolete beta-alanine biosynthetic process via 3-ureidopropionate definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 3-ureidopropionate.”
- database_cross_reference “GOC:mah”
obsolete beta-alanine biosynthetic process via 3-ureidopropionate deprecated true
obsolete beta-alanine biosynthetic process via 3-ureidopropionate term replaced by beta-alanine biosynthetic process
obsolete beta-alanine biosynthetic process via 3-ureidopropionate term tracker item “https://github.com/geneontology/go-ontology/issues/31510”^^anyURI

obsolete beta-alanine catabolic process to L-alanine `http://purl.obolibrary.org/obo/GO_0019485`

Removed

obsolete beta-alanine catabolic process to L-alanine definition “The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including L-alanine.”
- database_cross_reference “GOC:go_curators”
obsolete beta-alanine catabolic process to L-alanine label “beta-alanine catabolic process to L-alanine”
obsolete beta-alanine catabolic process to L-alanine SubClassOf obsolete L-alanine metabolic process
obsolete beta-alanine catabolic process to L-alanine SubClassOf beta-alanine catabolic process

Added

obsolete beta-alanine catabolic process to L-alanine deprecated true
obsolete beta-alanine catabolic process to L-alanine term replaced by beta-alanine catabolic process
obsolete beta-alanine catabolic process to L-alanine label “obsolete beta-alanine catabolic process to L-alanine”
obsolete beta-alanine catabolic process to L-alanine term tracker item “https://github.com/geneontology/go-ontology/issues/31361”^^anyURI
obsolete beta-alanine catabolic process to L-alanine comment “This term was obsoleted because it represents a variant pathway of beta-alanine degradation and is out of scope for GO.”
obsolete beta-alanine catabolic process to L-alanine definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including L-alanine.”
- database_cross_reference “GOC:curators”

obsolete beta-alanine catabolic process to mevalonate semialdehyde, by transamination `http://purl.obolibrary.org/obo/GO_0019486`

Removed

obsolete beta-alanine catabolic process to mevalonate semialdehyde, by transamination definition “The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including mevalonate semialdehyde, by transamination.”
- database_cross_reference “GOC:go_curators”
obsolete beta-alanine catabolic process to mevalonate semialdehyde, by transamination label “beta-alanine catabolic process to mevalonate semialdehyde, by transamination”
obsolete beta-alanine catabolic process to mevalonate semialdehyde, by transamination SubClassOf beta-alanine catabolic process

Added

obsolete beta-alanine catabolic process to mevalonate semialdehyde, by transamination label “obsolete beta-alanine catabolic process to mevalonate semialdehyde, by transamination”
obsolete beta-alanine catabolic process to mevalonate semialdehyde, by transamination definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including mevalonate semialdehyde, by transamination.”
- database_cross_reference “GOC:curators”
obsolete beta-alanine catabolic process to mevalonate semialdehyde, by transamination term tracker item “https://github.com/geneontology/go-ontology/issues/31361”^^anyURI
obsolete beta-alanine catabolic process to mevalonate semialdehyde, by transamination term replaced by beta-alanine catabolic process
obsolete beta-alanine catabolic process to mevalonate semialdehyde, by transamination deprecated true
obsolete beta-alanine catabolic process to mevalonate semialdehyde, by transamination comment “This term was obsoleted because it represents a variant pathway of beta-alanine degradation and is out of scope for GO.”

obsolete beta-galactosidase activity (lactose isomerization) `http://purl.obolibrary.org/obo/GO_0103033`

Removed

obsolete beta-galactosidase activity (lactose isomerization) database_cross_reference “MetaCyc:RXN0-5363”
obsolete beta-galactosidase activity (lactose isomerization) label “beta-galactosidase activity (lactose isomerization)”
obsolete beta-galactosidase activity (lactose isomerization) definition “Catalysis of the reaction: alpha-lactose = beta-(1->6)-galactobiose.”
- database_cross_reference “EC:5.4.1.-“
- database_cross_reference “GOC:pz”
obsolete beta-galactosidase activity (lactose isomerization) SubClassOf intramolecular acyltransferase activity

Added

obsolete beta-galactosidase activity (lactose isomerization) deprecated true
obsolete beta-galactosidase activity (lactose isomerization) comment “This term was obsoleted because it represents a specific substrate.”
obsolete beta-galactosidase activity (lactose isomerization) term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete beta-galactosidase activity (lactose isomerization) label “obsolete beta-galactosidase activity (lactose isomerization)”
obsolete beta-galactosidase activity (lactose isomerization) definition “OBSOLETE. Catalysis of the reaction: alpha-lactose = beta-(1->6)-galactobiose.”
- database_cross_reference “GOC:pz”

obsolete biological process `http://purl.obolibrary.org/obo/GO_0008371`

Removed

obsolete biological process definition “OBSOLETE. These are terms that have been removed from the active process ontology.”
- database_cross_reference “GOC:go_curators”

Added

obsolete biological process definition “OBSOLETE. These are terms that have been removed from the active process ontology.”
- database_cross_reference “GOC:curators”

obsolete biotin-protein ligase activity `http://purl.obolibrary.org/obo/GO_0018271`

Removed

obsolete biotin-protein ligase activity database_cross_reference “Reactome:R-HSA-2993802”
- label “HLCS biotinylates PC:Mn2+”
obsolete biotin-protein ligase activity database_cross_reference “Reactome:R-HSA-2993814”
- label “HLCS biotinylates ACACA:Mn2+”
obsolete biotin-protein ligase activity database_cross_reference “Reactome:R-HSA-9035988”
- label “Defective HLCS does not biotinylate PC:Mn2+”
obsolete biotin-protein ligase activity database_cross_reference “Reactome:R-HSA-2993799”
- label “HLCS biotinylates 6xMCCC1:6xMCCC2”
obsolete biotin-protein ligase activity database_cross_reference “Reactome:R-HSA-9035990”
- label “Defective HLCS does not biotinylate 6x(PCCA:PCCB)”
obsolete biotin-protein ligase activity database_cross_reference “Reactome:R-HSA-4167511”
- label “HLCS biotinylates ACACB”
obsolete biotin-protein ligase activity database_cross_reference “Reactome:R-HSA-2993447”
- label “HLCS biotinylates 6x(PCCA:PCCB)”
obsolete biotin-protein ligase activity database_cross_reference “Reactome:R-HSA-9035987”
- label “Defective HLCS does not biotinylate 6xMCCC1:6xMCCC2”
obsolete biotin-protein ligase activity database_cross_reference “Reactome:R-HSA-3323184”
- label “Defective HLCS does not biotinylate ACACA:Mn2+”

obsolete bud site selection/establishment of cell polarity (sensu Saccharomyces) `http://purl.obolibrary.org/obo/GO_0007115`

Removed

obsolete bud site selection/establishment of cell polarity (sensu Saccharomyces) definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete bud site selection/establishment of cell polarity (sensu Saccharomyces) definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete cadmium sensitivity/resistance `http://purl.obolibrary.org/obo/GO_0019830`

Removed

obsolete cadmium sensitivity/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete cadmium sensitivity/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete carbamate resistance `http://purl.obolibrary.org/obo/GO_0008161`

Removed

obsolete carbamate resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete carbamate resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete carbamate susceptibility/resistance `http://purl.obolibrary.org/obo/GO_0016353`

Removed

obsolete carbamate susceptibility/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete carbamate susceptibility/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete cell `http://purl.obolibrary.org/obo/GO_0005623`

Removed

obsolete cell definition “OBSOLETE. The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.”
- database_cross_reference “GOC:go_curators”

Added

obsolete cell definition “OBSOLETE. The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.”
- database_cross_reference “GOC:curators”

obsolete cell aging (sensu Fungi) `http://purl.obolibrary.org/obo/GO_0030463`

Removed

obsolete cell aging (sensu Fungi) definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete cell aging (sensu Fungi) definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete cell morphogenesis involved in differentiation `http://purl.obolibrary.org/obo/GO_0000904`

Removed

obsolete cell morphogenesis involved in differentiation definition “OBSOLETE. The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism’s life history.”
- database_cross_reference “GOC:go_curators”

Added

obsolete cell morphogenesis involved in differentiation definition “OBSOLETE. The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism’s life history.”
- database_cross_reference “GOC:curators”

obsolete cellular component `http://purl.obolibrary.org/obo/GO_0008370`

Removed

obsolete cellular component definition “OBSOLETE. These are terms that have been removed from the active component ontology.”
- database_cross_reference “GOC:go_curators”

Added

obsolete cellular component definition “OBSOLETE. These are terms that have been removed from the active component ontology.”
- database_cross_reference “GOC:curators”

obsolete cellular glucuronidation `http://purl.obolibrary.org/obo/GO_0052695`

Removed

obsolete cellular glucuronidation database_cross_reference “Reactome:R-HSA-156588”
- label “Glucuronidation”

obsolete cellular ketone body metabolic process `http://purl.obolibrary.org/obo/GO_0046950`

Removed

obsolete cellular ketone body metabolic process database_cross_reference “Reactome:R-HSA-74182”
- label “Ketone body metabolism”

obsolete cellular metabolic process `http://purl.obolibrary.org/obo/GO_0044237`

Removed

obsolete cellular metabolic process definition “OBSOLETE. The chemical reactions and pathways by which individual cells transform chemical substances.”
- database_cross_reference “GOC:go_curators”
obsolete cellular metabolic process database_cross_reference “Reactome:R-HSA-1428517”
- label “Aerobic respiration and respiratory electron transport”

Added

obsolete cellular metabolic process definition “OBSOLETE. The chemical reactions and pathways by which individual cells transform chemical substances.”
- database_cross_reference “GOC:curators”

obsolete cellular polysaccharide biosynthetic process `http://purl.obolibrary.org/obo/GO_0033692`

Removed

obsolete cellular polysaccharide biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, occurring at the level of an individual cell.”
- database_cross_reference “GOC:go_curators”

Added

obsolete cellular polysaccharide biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, occurring at the level of an individual cell.”
- database_cross_reference “GOC:curators”

obsolete cellular response to isolation stress `http://purl.obolibrary.org/obo/GO_0035901`

Removed

obsolete cellular response to isolation stress label “cellular response to isolation stress”
obsolete cellular response to isolation stress definition “Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lack of contact with other members of the same species.”
- database_cross_reference “GOC:bf”
- database_cross_reference “PMID:20203532”
obsolete cellular response to isolation stress SubClassOf cellular response to stress
obsolete cellular response to isolation stress SubClassOf response to isolation stress

Added

obsolete cellular response to isolation stress deprecated true
obsolete cellular response to isolation stress comment “This term was obsoleted because it represents the molecular activities involved in response to isolation stress ; GO:0035900.”
obsolete cellular response to isolation stress label “obsolete cellular response to isolation stress”
obsolete cellular response to isolation stress definition “OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lack of contact with other members of the same species.”
- database_cross_reference “GOC:bf”
- database_cross_reference “PMID:20203532”
obsolete cellular response to isolation stress term replaced by response to isolation stress
obsolete cellular response to isolation stress term tracker item “https://github.com/geneontology/go-ontology/issues/31407”^^anyURI

obsolete centromere binding `http://purl.obolibrary.org/obo/GO_0007002`

Removed

obsolete centromere binding definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete centromere binding definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete chaperone mediated protein folding independent of cofactor `http://purl.obolibrary.org/obo/GO_0051086`

Removed

obsolete chaperone mediated protein folding independent of cofactor database_cross_reference “Reactome:R-HSA-390450”
- label “Folding of actin by CCT/TriC”

obsolete chitin catabolic process to fructose 6-phosphate via glucosamine `http://purl.obolibrary.org/obo/GO_0052776`

Removed

obsolete chitin catabolic process to fructose 6-phosphate via glucosamine database_cross_reference “MetaCyc:PWY-6855”
obsolete chitin catabolic process to fructose 6-phosphate via glucosamine label “chitin catabolic process to fructose 6-phosphate via glucosamine”
obsolete chitin catabolic process to fructose 6-phosphate via glucosamine definition “The pathway resulting in the breakdown of chitin into fructose 6-phosphate, via glucosamine; acetate is also produced during the process.”
- database_cross_reference “MetaCyc:PWY-6855”
- database_cross_reference “GOC:bf”
- database_cross_reference “PMID:16736587”
- database_cross_reference “PMID:16232910”
- database_cross_reference “PMID:15136574”
- database_cross_reference “GOC:mengo_curators”
obsolete chitin catabolic process to fructose 6-phosphate via glucosamine SubClassOf phosphate-containing compound metabolic process
obsolete chitin catabolic process to fructose 6-phosphate via glucosamine SubClassOf acetate metabolic process
obsolete chitin catabolic process to fructose 6-phosphate via glucosamine SubClassOf chitin catabolic process
obsolete chitin catabolic process to fructose 6-phosphate via glucosamine SubClassOf organophosphate metabolic process
obsolete chitin catabolic process to fructose 6-phosphate via glucosamine SubClassOf has part some diacetylchitobiose deacetylase activity
obsolete chitin catabolic process to fructose 6-phosphate via glucosamine SubClassOf has part some exo-1,4-beta-D-glucosaminidase activity
obsolete chitin catabolic process to fructose 6-phosphate via glucosamine SubClassOf has part some N-acetylglucosamine deacetylase activity

Added

obsolete chitin catabolic process to fructose 6-phosphate via glucosamine term replaced by chitin catabolic process
obsolete chitin catabolic process to fructose 6-phosphate via glucosamine deprecated true
obsolete chitin catabolic process to fructose 6-phosphate via glucosamine label “obsolete chitin catabolic process to fructose 6-phosphate via glucosamine”
obsolete chitin catabolic process to fructose 6-phosphate via glucosamine term tracker item “https://github.com/geneontology/go-ontology/issues/31633”^^anyURI
obsolete chitin catabolic process to fructose 6-phosphate via glucosamine comment “The reason for obsoletion is that the term is too specific and represents a GO-CAM model.”
obsolete chitin catabolic process to fructose 6-phosphate via glucosamine definition “OBSOLETE. The pathway resulting in the breakdown of chitin into fructose 6-phosphate, via glucosamine; acetate is also produced during the process.”
- database_cross_reference “GOC:bf”
- database_cross_reference “PMID:16736587”
- database_cross_reference “PMID:16232910”
- database_cross_reference “PMID:15136574”
- database_cross_reference “GOC:mengo_curators”

obsolete chondroitin sulfate biosynthetic process `http://purl.obolibrary.org/obo/GO_0030206`

Removed

obsolete chondroitin sulfate biosynthetic process database_cross_reference “Reactome:R-HSA-2022870”
- label “Chondroitin sulfate biosynthesis”

obsolete chondroitin sulfate metabolic process `http://purl.obolibrary.org/obo/GO_0030204`

Removed

obsolete chondroitin sulfate metabolic process database_cross_reference “Reactome:R-HSA-1793185”
- label “Chondroitin sulfate/dermatan sulfate metabolism”

obsolete chondroitin sulfate proteoglycan `http://purl.obolibrary.org/obo/GO_0005204`

Removed

obsolete chondroitin sulfate proteoglycan definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete chondroitin sulfate proteoglycan definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete chondroitin sulfate/dermatan sulfate proteoglycan `http://purl.obolibrary.org/obo/GO_0005205`

Removed

obsolete chondroitin sulfate/dermatan sulfate proteoglycan definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete chondroitin sulfate/dermatan sulfate proteoglycan definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete chromate sensitivity/resistance `http://purl.obolibrary.org/obo/GO_0019831`

Removed

obsolete chromate sensitivity/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete chromate sensitivity/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete citronellyl-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0034823`

Removed

obsolete citronellyl-CoA ligase activity label “citronellyl-CoA ligase activity”
obsolete citronellyl-CoA ligase activity database_cross_reference “UM-BBD_reactionID:r1157”
obsolete citronellyl-CoA ligase activity definition “Catalysis of the reaction: citronellate + CoASH + ATP = citronellyl-CoA + AMP + PPi.”
- database_cross_reference “UM-BBD_reactionID:r1157”
obsolete citronellyl-CoA ligase activity database_cross_reference “KEGG_REACTION:R08088”
obsolete citronellyl-CoA ligase activity SubClassOf acid-thiol ligase activity
obsolete citronellyl-CoA ligase activity SubClassOf CoA-ligase activity

Added

obsolete citronellyl-CoA ligase activity definition “OBSOLETE. Catalysis of the reaction: citronellate + CoASH + ATP = citronellyl-CoA + AMP + PPi.”
- database_cross_reference “GOC:curators”
obsolete citronellyl-CoA ligase activity label “obsolete citronellyl-CoA ligase activity”
obsolete citronellyl-CoA ligase activity deprecated true
obsolete citronellyl-CoA ligase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete citronellyl-CoA ligase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI

obsolete clathrin adaptor `http://purl.obolibrary.org/obo/GO_0005906`

Removed

obsolete clathrin adaptor definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete clathrin adaptor definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete coatomer `http://purl.obolibrary.org/obo/GO_0005799`

Removed

obsolete coatomer definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete coatomer definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete coenzyme B metabolic process `http://purl.obolibrary.org/obo/GO_0019297`

Removed

obsolete coenzyme B metabolic process definition “OBSOLETE. The chemical reactions and pathways involving coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes.”
- database_cross_reference “GOC:go_curators”

Added

obsolete coenzyme B metabolic process definition “OBSOLETE. The chemical reactions and pathways involving coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes.”
- database_cross_reference “GOC:curators”

obsolete coenzyme M metabolic process `http://purl.obolibrary.org/obo/GO_0019296`

Removed

obsolete coenzyme M metabolic process definition “OBSOLETE. The chemical reactions and pathways involving coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes.”
- database_cross_reference “GOC:go_curators”

Added

obsolete coenzyme M metabolic process definition “OBSOLETE. The chemical reactions and pathways involving coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes.”
- database_cross_reference “GOC:curators”

obsolete collagen `http://purl.obolibrary.org/obo/GO_0005202`

Removed

obsolete collagen definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete collagen definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete commitment to apoptosis `http://purl.obolibrary.org/obo/GO_0006920`

Removed

obsolete commitment to apoptosis definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete commitment to apoptosis definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete coniferyl aldehyde 5-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0102126`

Removed

obsolete coniferyl aldehyde 5-hydroxylase activity database_cross_reference “MetaCyc:RXN-1142”
obsolete coniferyl aldehyde 5-hydroxylase activity definition “Catalysis of the reaction: H+ + coniferyl aldehyde + NADPH + O2 = 5-hydroxy-coniferaldehyde + NADP + H2O.”
- database_cross_reference “GOC:pz”
obsolete coniferyl aldehyde 5-hydroxylase activity label “coniferyl aldehyde 5-hydroxylase activity”
obsolete coniferyl aldehyde 5-hydroxylase activity SubClassOf oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

Added

obsolete coniferyl aldehyde 5-hydroxylase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete coniferyl aldehyde 5-hydroxylase activity deprecated true
obsolete coniferyl aldehyde 5-hydroxylase activity label “obsolete coniferyl aldehyde 5-hydroxylase activity”
obsolete coniferyl aldehyde 5-hydroxylase activity definition “OBSOLETE. Catalysis of the reaction: H+ + coniferyl aldehyde + NADPH + O2 = 5-hydroxy-coniferaldehyde + NADP + H2O.”
- database_cross_reference “GOC:pz”
obsolete coniferyl aldehyde 5-hydroxylase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI

obsolete copper sensitivity/resistance `http://purl.obolibrary.org/obo/GO_0045139`

Removed

obsolete copper sensitivity/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete copper sensitivity/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete copper-exporting ATPase activity `http://purl.obolibrary.org/obo/GO_0022825`

Removed

obsolete copper-exporting ATPase activity definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete copper-exporting ATPase activity definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete cyclin-dependent protein kinase activating kinase activity `http://purl.obolibrary.org/obo/GO_0019912`

Removed

obsolete cyclin-dependent protein kinase activating kinase activity definition “OBSOLETE. Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK).”
- database_cross_reference “GOC:go_curators”

Added

obsolete cyclin-dependent protein kinase activating kinase activity definition “OBSOLETE. Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK).”
- database_cross_reference “GOC:curators”

obsolete cyclodiene resistance `http://purl.obolibrary.org/obo/GO_0008162`

Removed

obsolete cyclodiene resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete cyclodiene resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete cyclodiene susceptibility/resistance `http://purl.obolibrary.org/obo/GO_0016354`

Removed

obsolete cyclodiene susceptibility/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete cyclodiene susceptibility/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete cyclohex-1-ene-1-carboxyl-CoA hydratase activity `http://purl.obolibrary.org/obo/GO_0018811`

Removed

obsolete cyclohex-1-ene-1-carboxyl-CoA hydratase activity database_cross_reference “MetaCyc:R266-RXN”
obsolete cyclohex-1-ene-1-carboxyl-CoA hydratase activity label “cyclohex-1-ene-1-carboxyl-CoA hydratase activity”
obsolete cyclohex-1-ene-1-carboxyl-CoA hydratase activity definition “Catalysis of the reaction: cyclohex-1-ene-1-carboxyl-CoA + H2O = 2-hydroxycyclohexane-1-carboxyl-CoA.”
- database_cross_reference “MetaCyc:R266-RXN”
- database_cross_reference “UM-BBD_reactionID:r0191”
obsolete cyclohex-1-ene-1-carboxyl-CoA hydratase activity database_cross_reference “UM-BBD_reactionID:r0191”
obsolete cyclohex-1-ene-1-carboxyl-CoA hydratase activity SubClassOf hydro-lyase activity

Added

obsolete cyclohex-1-ene-1-carboxyl-CoA hydratase activity definition “OBSOLETE. Catalysis of the reaction: cyclohex-1-ene-1-carboxyl-CoA + H2O = 2-hydroxycyclohexane-1-carboxyl-CoA.”
- database_cross_reference “GOC:curators”
obsolete cyclohex-1-ene-1-carboxyl-CoA hydratase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete cyclohex-1-ene-1-carboxyl-CoA hydratase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete cyclohex-1-ene-1-carboxyl-CoA hydratase activity label “obsolete cyclohex-1-ene-1-carboxyl-CoA hydratase activity”
obsolete cyclohex-1-ene-1-carboxyl-CoA hydratase activity deprecated true

obsolete cysteine catabolic process `http://purl.obolibrary.org/obo/GO_0009093`

Removed

obsolete cysteine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of cysteine, 2-amino-3-mercaptopropanoic acid.”
- database_cross_reference “GOC:go_curators”

Added

obsolete cysteine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of cysteine, 2-amino-3-mercaptopropanoic acid.”
- database_cross_reference “GOC:curators”

obsolete cysteine metabolic process `http://purl.obolibrary.org/obo/GO_0006534`

Removed

obsolete cysteine metabolic process label “cysteine metabolic process”
obsolete cysteine metabolic process definition “The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid.”
- database_cross_reference “GOC:go_curators”
obsolete cysteine metabolic process SubClassOf sulfur amino acid metabolic process
obsolete cysteine metabolic process SubClassOf alpha-amino acid metabolic process

Added

obsolete cysteine metabolic process label “obsolete cysteine metabolic process”
obsolete cysteine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid.”
- database_cross_reference “GOC:curators”
obsolete cysteine metabolic process consider L-cysteine biosynthetic process
obsolete cysteine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31281”^^anyURI
obsolete cysteine metabolic process deprecated true
obsolete cysteine metabolic process consider L-cysteine catabolic process
obsolete cysteine metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”

obsolete cysteine-type endopeptidase activity involved in apoptotic process `http://purl.obolibrary.org/obo/GO_0097153`

Removed

obsolete cysteine-type endopeptidase activity involved in apoptotic process database_cross_reference “Reactome:R-HSA-6800797”
- label “The PIDDosome activates CASP2”

obsolete cytidine biosynthetic process `http://purl.obolibrary.org/obo/GO_0046088`

Removed

obsolete cytidine biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of cytidine, cytosine riboside, a widely distributed nucleoside.”
- database_cross_reference “GOC:go_curators”

Added

obsolete cytidine biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of cytidine, cytosine riboside, a widely distributed nucleoside.”
- database_cross_reference “GOC:curators”

obsolete cytokinesis, protein recruitment `http://purl.obolibrary.org/obo/GO_0007106`

Removed

obsolete cytokinesis, protein recruitment definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete cytokinesis, protein recruitment definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete cytosine biosynthetic process `http://purl.obolibrary.org/obo/GO_0046089`

Removed

obsolete cytosine biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives.”
- database_cross_reference “GOC:go_curators”

Added

obsolete cytosine biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives.”
- database_cross_reference “GOC:curators”

obsolete defense/immunity protein activity `http://purl.obolibrary.org/obo/GO_0003793`

Removed

obsolete defense/immunity protein activity definition “OBSOLETE. Any activity that plays a role in the defense/immune response of an organism against infection and disease.”
- database_cross_reference “GOC:go_curators”

Added

obsolete defense/immunity protein activity definition “OBSOLETE. Any activity that plays a role in the defense/immune response of an organism against infection and disease.”
- database_cross_reference “GOC:curators”

obsolete deisopropylhydroxyatrazine aminohydrolase activity `http://purl.obolibrary.org/obo/GO_0018757`

Removed

obsolete deisopropylhydroxyatrazine aminohydrolase activity definition “Catalysis of the reaction: deisopropylhydroxyatrazine + H2O = NH3 + 2,4-dihydroxy-6-(N’-ethyl)amino-1,3,5-triazine.”
- database_cross_reference “UM-BBD_reactionID:r0121”
obsolete deisopropylhydroxyatrazine aminohydrolase activity label “deisopropylhydroxyatrazine aminohydrolase activity”
obsolete deisopropylhydroxyatrazine aminohydrolase activity SubClassOf hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

Added

obsolete deisopropylhydroxyatrazine aminohydrolase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31530”^^anyURI
obsolete deisopropylhydroxyatrazine aminohydrolase activity deprecated true
obsolete deisopropylhydroxyatrazine aminohydrolase activity definition “OBSOLETE. Catalysis of the reaction: deisopropylhydroxyatrazine + H2O = NH4+ + 2,4-dihydroxy-6-(N’-ethyl)amino-1,3,5-triazine.”
- database_cross_reference “UM-BBD_reactionID:r0121”
obsolete deisopropylhydroxyatrazine aminohydrolase activity label “obsolete deisopropylhydroxyatrazine aminohydrolase activity”
obsolete deisopropylhydroxyatrazine aminohydrolase activity comment “This term was obsoleted because there is no evidence that this reaction exists.”

obsolete deoxyribonucleoside diphosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009186`

Removed

obsolete deoxyribonucleoside diphosphate metabolic process definition “OBSOLETE. The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

obsolete deoxyribonucleoside diphosphate metabolic process definition “OBSOLETE. The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

obsolete deoxyribonucleoside monophosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009162`

Removed

obsolete deoxyribonucleoside monophosphate metabolic process definition “OBSOLETE. The chemical reactions and pathways involving a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

obsolete deoxyribonucleoside monophosphate metabolic process definition “OBSOLETE. The chemical reactions and pathways involving a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

obsolete dermatan sulfate biosynthetic process `http://purl.obolibrary.org/obo/GO_0030208`

Removed

obsolete dermatan sulfate biosynthetic process database_cross_reference “Reactome:R-HSA-2022923”
- label “Dermatan sulfate biosynthesis”

obsolete detection of chemical stimulus involved in sensory perception of salty taste `http://purl.obolibrary.org/obo/GO_0001583`

Removed

obsolete detection of chemical stimulus involved in sensory perception of salty taste definition “OBSOLETE. The series of events required for a salty taste stimulus to be received and converted to a molecular signal.”
- database_cross_reference “GOC:go_curators”

Added

obsolete detection of chemical stimulus involved in sensory perception of salty taste definition “OBSOLETE. The series of events required for a salty taste stimulus to be received and converted to a molecular signal.”
- database_cross_reference “GOC:curators”

obsolete diaminopimelate biosynthetic process `http://purl.obolibrary.org/obo/GO_0019877`

Removed

obsolete diaminopimelate biosynthetic process label “diaminopimelate biosynthetic process”
obsolete diaminopimelate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls.”
- database_cross_reference “GOC:ma”
- database_cross_reference “ISBN:0198547684”
obsolete diaminopimelate biosynthetic process SubClassOf amino acid biosynthetic process
obsolete diaminopimelate biosynthetic process SubClassOf dicarboxylic acid biosynthetic process
obsolete diaminopimelate biosynthetic process SubClassOf fatty acid derivative biosynthetic process

Added

obsolete diaminopimelate biosynthetic process deprecated true
obsolete diaminopimelate biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31510”^^anyURI
obsolete diaminopimelate biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls.”
- database_cross_reference “GOC:ma”
- database_cross_reference “ISBN:0198547684”
obsolete diaminopimelate biosynthetic process label “obsolete diaminopimelate biosynthetic process”
obsolete diaminopimelate biosynthetic process consider L-leucine biosynthetic process
obsolete diaminopimelate biosynthetic process comment “This term was obsoleted because it represents an intermediate in L-leucine biosynthesis.”

obsolete dihydrophloroglucinol hydrolase activity `http://purl.obolibrary.org/obo/GO_0018766`

Removed

obsolete dihydrophloroglucinol hydrolase activity label “dihydrophloroglucinol hydrolase activity”
obsolete dihydrophloroglucinol hydrolase activity definition “Catalysis of the reaction: dihydrophloroglucinol + OH- = 3-hydroxy-5-oxohexanoate.”
- database_cross_reference “UM-BBD_reactionID:r0008”
obsolete dihydrophloroglucinol hydrolase activity database_cross_reference “KEGG_REACTION:R07831”
obsolete dihydrophloroglucinol hydrolase activity database_cross_reference “MetaCyc:R6-RXN”
obsolete dihydrophloroglucinol hydrolase activity database_cross_reference “UM-BBD_reactionID:r0008”
obsolete dihydrophloroglucinol hydrolase activity SubClassOf hydrolase activity, acting on carbon-carbon bonds, in ketonic substances

Added

obsolete dihydrophloroglucinol hydrolase activity label “obsolete dihydrophloroglucinol hydrolase activity”
obsolete dihydrophloroglucinol hydrolase activity deprecated true
obsolete dihydrophloroglucinol hydrolase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete dihydrophloroglucinol hydrolase activity definition “OBSOLETE. Catalysis of the reaction: dihydrophloroglucinol + OH- = 3-hydroxy-5-oxohexanoate.”
- database_cross_reference “GOC:curators”
obsolete dihydrophloroglucinol hydrolase activity comment “This term was obsoleted because it represents a specific substrate.”

obsolete discadenine biosynthetic process `http://purl.obolibrary.org/obo/GO_0034268`

Removed

obsolete discadenine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid.”
- database_cross_reference “GOC:mah”
obsolete discadenine biosynthetic process label “discadenine biosynthetic process”
obsolete discadenine biosynthetic process SubClassOf purine-containing compound biosynthetic process
obsolete discadenine biosynthetic process SubClassOf cytokinin biosynthetic process
obsolete discadenine biosynthetic process SubClassOf L-amino acid biosynthetic process
obsolete discadenine biosynthetic process SubClassOf non-proteinogenic amino acid biosynthetic process

Added

obsolete discadenine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31510”^^anyURI
obsolete discadenine biosynthetic process label “obsolete discadenine biosynthetic process”
obsolete discadenine biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid.”
- database_cross_reference “GOC:mah”
obsolete discadenine biosynthetic process deprecated true
obsolete discadenine biosynthetic process comment “The reason for merging the above terms is to clean up this branch, consistent to what has been done previously.”

obsolete discadenine catabolic process `http://purl.obolibrary.org/obo/GO_0034269`

Removed

obsolete discadenine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid.”
- database_cross_reference “GOC:mah”
obsolete discadenine catabolic process label “discadenine catabolic process”
obsolete discadenine catabolic process SubClassOf L-amino acid catabolic process
obsolete discadenine catabolic process SubClassOf cytokinin catabolic process
obsolete discadenine catabolic process SubClassOf non-proteinogenic amino acid catabolic process
obsolete discadenine catabolic process SubClassOf purine-containing compound catabolic process

Added

obsolete discadenine catabolic process deprecated true
obsolete discadenine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31361”^^anyURI
obsolete discadenine catabolic process comment “This term was obsoleted because there is no evidence that a specific pathway for discadenine degradation exists.”
obsolete discadenine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid.”
- database_cross_reference “GOC:mah”
obsolete discadenine catabolic process label “obsolete discadenine catabolic process”

obsolete disease resistance `http://purl.obolibrary.org/obo/GO_0009614`

Removed

obsolete disease resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete disease resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity `http://purl.obolibrary.org/obo/GO_0036426`

Removed

obsolete ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity label “ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity”
obsolete ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity database_cross_reference “MetaCyc:2.4.1.54-RXN”
obsolete ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity database_cross_reference “KEGG_REACTION:R07257”
obsolete ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity definition “Catalysis of the reaction: ditrans,octacis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate+ GDP.”
- database_cross_reference “GOC:curators”
obsolete ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity SubClassOf undecaprenyl-phosphate mannosyltransferase activity

Added

obsolete ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity definition “OBSOLETE. Catalysis of the reaction: ditrans,octacis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate+ GDP.”
- database_cross_reference “GOC:curators”
obsolete ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity label “obsolete ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity”
obsolete ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity deprecated true

obsolete drought tolerance `http://purl.obolibrary.org/obo/GO_0009633`

Removed

obsolete drought tolerance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete drought tolerance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete drug resistance `http://purl.obolibrary.org/obo/GO_0009315`

Removed

obsolete drug resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete drug resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete early endosome to recycling endosome transport `http://purl.obolibrary.org/obo/GO_0061502`

Removed

obsolete early endosome to recycling endosome transport definition “The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the recycling endosomes.”
- database_cross_reference “GOC:dph”
- database_cross_reference “PMID:21474295”
- database_cross_reference “GOC:kmv”
obsolete early endosome to recycling endosome transport label “early endosome to recycling endosome transport”
obsolete early endosome to recycling endosome transport SubClassOf vesicle-mediated transport between endosomal compartments
obsolete early endosome to recycling endosome transport SubClassOf occurs in some cytoplasm

Added

obsolete early endosome to recycling endosome transport deprecated true
obsolete early endosome to recycling endosome transport label “obsolete early endosome to recycling endosome transport”
obsolete early endosome to recycling endosome transport term replaced by endocytic recycling
obsolete early endosome to recycling endosome transport definition “OBSOLETE. The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the recycling endosomes.”
- database_cross_reference “GOC:dph”
- database_cross_reference “PMID:21474295”
- database_cross_reference “GOC:kmv”
obsolete early endosome to recycling endosome transport term tracker item “https://github.com/geneontology/go-ontology/issues/31240”^^anyURI
obsolete early endosome to recycling endosome transport comment “This term is described by another GO term”

obsolete electron transfer carrier `http://purl.obolibrary.org/obo/GO_0018997`

Removed

obsolete electron transfer carrier definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete electron transfer carrier definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete endocytotic transport vesicle `http://purl.obolibrary.org/obo/GO_0005810`

Removed

obsolete endocytotic transport vesicle definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete endocytotic transport vesicle definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete eoxin A4 synthase activity `http://purl.obolibrary.org/obo/GO_0097260`

Removed

obsolete eoxin A4 synthase activity database_cross_reference “Reactome:R-HSA-2162019”
- label “LTA4 is converted to EXA4 by ALOX15”

obsolete epsilon-caprolactam lactamase activity `http://purl.obolibrary.org/obo/GO_0018752`

Removed

obsolete epsilon-caprolactam lactamase activity label “epsilon-caprolactam lactamase activity”
obsolete epsilon-caprolactam lactamase activity database_cross_reference “UM-BBD_reactionID:r0448”
obsolete epsilon-caprolactam lactamase activity database_cross_reference “MetaCyc:R561-RXN”
obsolete epsilon-caprolactam lactamase activity definition “Catalysis of the reaction: epsilon-caprolactam + H2O = H+ + 6-aminohexanoate.”
- database_cross_reference “UM-BBD_reactionID:r0448”
obsolete epsilon-caprolactam lactamase activity SubClassOf hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

Added

obsolete epsilon-caprolactam lactamase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete epsilon-caprolactam lactamase activity label “obsolete epsilon-caprolactam lactamase activity”
obsolete epsilon-caprolactam lactamase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete epsilon-caprolactam lactamase activity deprecated true
obsolete epsilon-caprolactam lactamase activity definition “OBSOLETE. Catalysis of the reaction: epsilon-caprolactam + H2O = H+ + 6-aminohexanoate.”
- database_cross_reference “GOC:curators”

obsolete eriodictyol 4’-O-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0102762`

Removed

obsolete eriodictyol 4’-O-methyltransferase activity definition “Catalysis of the reaction: eriodictyol + S-adenosyl-L-methionine = H+ + hesperetin(1-) + S-adenosyl-L-homocysteine.”
- database_cross_reference “GOC:pz”
- database_cross_reference “MetaCyc:RXN-7754”
obsolete eriodictyol 4’-O-methyltransferase activity label “eriodictyol 4’-O-methyltransferase activity”
obsolete eriodictyol 4’-O-methyltransferase activity database_cross_reference “MetaCyc:RXN-7754”
obsolete eriodictyol 4’-O-methyltransferase activity SubClassOf methyltransferase activity

Added

obsolete eriodictyol 4’-O-methyltransferase activity label “obsolete eriodictyol 4’-O-methyltransferase activity”
obsolete eriodictyol 4’-O-methyltransferase activity definition “OBSOLETE. Catalysis of the reaction: eriodictyol + S-adenosyl-L-methionine = H+ + hesperetin(1-) + S-adenosyl-L-homocysteine.”
- database_cross_reference “GOC:pz”
obsolete eriodictyol 4’-O-methyltransferase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete eriodictyol 4’-O-methyltransferase activity deprecated true
obsolete eriodictyol 4’-O-methyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI

obsolete eukaryotic translation initiation factor 4 complex `http://purl.obolibrary.org/obo/GO_0008304`

Removed

obsolete eukaryotic translation initiation factor 4 complex definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete eukaryotic translation initiation factor 4 complex definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete extracellular polysaccharide biosynthetic process `http://purl.obolibrary.org/obo/GO_0045226`

Removed

obsolete extracellular polysaccharide biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:ai”

Added

obsolete extracellular polysaccharide biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:ai”

obsolete extracellular space `http://purl.obolibrary.org/obo/GO_0005615`

Removed

obsolete extracellular space in_subset goslim_drosophila
obsolete extracellular space in_subset goslim_chembl
obsolete extracellular space comment “Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term.”
obsolete extracellular space definition “That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.”
- database_cross_reference “ISBN:0198547684”
obsolete extracellular space in_subset goslim_generic
obsolete extracellular space label “extracellular space”
obsolete extracellular space SubClassOf part of some extracellular region
obsolete extracellular space SubClassOf cellular anatomical structure

Added

obsolete extracellular space label “obsolete extracellular space”
obsolete extracellular space deprecated true
obsolete extracellular space term tracker item “https://github.com/geneontology/go-ontology/issues/31545”^^anyURI
obsolete extracellular space term replaced by extracellular region
obsolete extracellular space definition “OBSOLETE. That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.”
- database_cross_reference “ISBN:0198547684”
obsolete extracellular space comment “This term was obsoleted because it represents the same concept as extracellular region; GO:0005576.”

obsolete farnesyl-diphosphate farnesyltransferase activity `http://purl.obolibrary.org/obo/GO_0004310`

Removed

obsolete farnesyl-diphosphate farnesyltransferase activity database_cross_reference “Reactome:R-HSA-191405”
- label “Two FPP molecules dimerize to form presqualene diphosphate”
obsolete farnesyl-diphosphate farnesyltransferase activity database_cross_reference “Reactome:R-HSA-191402”
- label “Reduction of presqualene diphosphate to form squalene”

obsolete fat body metabolic process (sensu Insecta) `http://purl.obolibrary.org/obo/GO_0007590`

Removed

obsolete fat body metabolic process (sensu Insecta) definition “OBSOLETE. The chemical reactions and pathways involving the fat body. A fat body is a fat-containing cellular structure which serves as an energy reserve. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557).”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

obsolete fat body metabolic process (sensu Insecta) definition “OBSOLETE. The chemical reactions and pathways involving the fat body. A fat body is a fat-containing cellular structure which serves as an energy reserve. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557).”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

obsolete fat-soluble vitamin metabolic process `http://purl.obolibrary.org/obo/GO_0006775`

Removed

obsolete fat-soluble vitamin metabolic process database_cross_reference “Reactome:R-HSA-6806667”
- label “Metabolism of fat-soluble vitamins”

obsolete freezing tolerance `http://purl.obolibrary.org/obo/GO_0009632`

Removed

obsolete freezing tolerance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete freezing tolerance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete frizzled receptor activity `http://purl.obolibrary.org/obo/GO_0004928`

Removed

obsolete frizzled receptor activity definition “OBSOLETE. Combining with a member of the Wnt-family of signaling molecules to initiate a change in cell activity.”
- database_cross_reference “GOC:go_curators”

Added

obsolete frizzled receptor activity definition “OBSOLETE. Combining with a member of the Wnt-family of signaling molecules to initiate a change in cell activity.”
- database_cross_reference “GOC:curators”

obsolete frizzled-2 receptor activity `http://purl.obolibrary.org/obo/GO_0004929`

Removed

obsolete frizzled-2 receptor activity definition “OBSOLETE. Combining with to a member of the Wnt-family of signaling molecules to initiate a change in cell activity.”
- database_cross_reference “GOC:go_curators”

Added

obsolete frizzled-2 receptor activity definition “OBSOLETE. Combining with to a member of the Wnt-family of signaling molecules to initiate a change in cell activity.”
- database_cross_reference “GOC:curators”

obsolete fucose catabolic process `http://purl.obolibrary.org/obo/GO_0019317`

Removed

obsolete fucose catabolic process has_exact_synonym “fucose degradation”
obsolete fucose catabolic process definition “The chemical reactions and pathways resulting in the breakdown of fucose (6-deoxygalactose).”
- database_cross_reference “GOC:jl”
obsolete fucose catabolic process has_exact_synonym “fucose catabolism”
obsolete fucose catabolic process label “fucose catabolic process”
obsolete fucose catabolic process has_exact_synonym “fucose breakdown”
obsolete fucose catabolic process database_cross_reference “MetaCyc:FUCCAT-PWY”
obsolete fucose catabolic process SubClassOf hexose catabolic process
obsolete fucose catabolic process SubClassOf fucose metabolic process

Added

obsolete fucose catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31652”^^anyURI
obsolete fucose catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of fucose (6-deoxygalactose).”
- database_cross_reference “GOC:jl”
obsolete fucose catabolic process deprecated true
obsolete fucose catabolic process term replaced by L-fucose catabolic process
obsolete fucose catabolic process comment “The reason for obsoletion is that this term is redundant with its more specific child term GO:0042355 ‘L-fucose catabolic process’. The existing annotations appear to be specific for L-fucose based on the protein names.”
obsolete fucose catabolic process label “obsolete fucose catabolic process”

obsolete glucarate catabolic process `http://purl.obolibrary.org/obo/GO_0019394`

Removed

obsolete glucarate catabolic process has_exact_synonym “glucarate catabolism”
obsolete glucarate catabolic process label “glucarate catabolic process”
obsolete glucarate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of glucarate, the anion of glucaric acid.”
- database_cross_reference “ISBN:0198506732”
obsolete glucarate catabolic process has_exact_synonym “glucarate degradation”
obsolete glucarate catabolic process database_cross_reference “MetaCyc:GLUCARDEG-PWY”
obsolete glucarate catabolic process has_exact_synonym “glucarate breakdown”
obsolete glucarate catabolic process SubClassOf aldaric acid catabolic process

Added

obsolete glucarate catabolic process deprecated true
obsolete glucarate catabolic process comment “The reason for obsoletion is that this term is redundant with its more specific child term GO:0042838 ‘D-glucarate catabolic process’. The existing annotations are specific for D-glucarate.”
obsolete glucarate catabolic process label “obsolete glucarate catabolic process”
obsolete glucarate catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glucarate, the anion of glucaric acid.”
- database_cross_reference “ISBN:0198506732”
obsolete glucarate catabolic process term replaced by D-glucarate catabolic process
obsolete glucarate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31652”^^anyURI

obsolete glucose catabolic process to lactate `http://purl.obolibrary.org/obo/GO_0019659`

Removed

obsolete glucose catabolic process to lactate label “glucose catabolic process to lactate”
obsolete glucose catabolic process to lactate definition “The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, and possibly ethanol, yielding energy in the form of adenosine triphosphate (ATP).”
- database_cross_reference “GOC:jl”
obsolete glucose catabolic process to lactate in_subset gocheck_do_not_annotate
obsolete glucose catabolic process to lactate SubClassOf fermentation
obsolete glucose catabolic process to lactate SubClassOf lactate metabolic process
obsolete glucose catabolic process to lactate SubClassOf glucose catabolic process

Added

obsolete glucose catabolic process to lactate comment “The reason for obsoletion is that this term was an unnecessary grouping term.”
obsolete glucose catabolic process to lactate definition “OBSOLETE. The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, and possibly ethanol, yielding energy in the form of adenosine triphosphate (ATP).”
- database_cross_reference “GOC:jl”
obsolete glucose catabolic process to lactate term tracker item “https://github.com/geneontology/go-ontology/issues/31217”^^anyURI
obsolete glucose catabolic process to lactate deprecated true
obsolete glucose catabolic process to lactate label “obsolete glucose catabolic process to lactate”

obsolete glucose transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0005355`

Removed

obsolete glucose transmembrane transporter activity database_cross_reference “Reactome:R-HSA-5653873”
- label “SLC2A1 tetramer transports Glc from cytosol to Golgi lumen”
obsolete glucose transmembrane transporter activity database_cross_reference “Reactome:R-HSA-499981”
- label “Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2”

obsolete glutamate biosynthetic process `http://purl.obolibrary.org/obo/GO_0006537`

Removed

obsolete glutamate biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid.”
- database_cross_reference “GOC:go_curators”

Added

obsolete glutamate biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid.”
- database_cross_reference “GOC:curators”

obsolete glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+) `http://purl.obolibrary.org/obo/GO_0019268`

Removed

obsolete glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+) definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, catalyzed by the enzyme glutamate dehydrogenase (NADP+).”
- database_cross_reference “GOC:go_curators”

Added

obsolete glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+) definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, catalyzed by the enzyme glutamate dehydrogenase (NADP+).”
- database_cross_reference “GOC:curators”

obsolete glutamate biosynthetic process, using glutamate synthase (NADPH) `http://purl.obolibrary.org/obo/GO_0019269`

Removed

obsolete glutamate biosynthetic process, using glutamate synthase (NADPH) definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, catalyzed by the enzyme glutamate synthase (NADPH).”
- database_cross_reference “GOC:go_curators”

Added

obsolete glutamate biosynthetic process, using glutamate synthase (NADPH) definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, catalyzed by the enzyme glutamate synthase (NADPH).”
- database_cross_reference “GOC:curators”

obsolete glutamate catabolic process to 2-oxoglutarate `http://purl.obolibrary.org/obo/GO_0019551`

Removed

obsolete glutamate catabolic process to 2-oxoglutarate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including 2-oxoglutarate.”
- database_cross_reference “GOC:go_curators”

Added

obsolete glutamate catabolic process to 2-oxoglutarate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including 2-oxoglutarate.”
- database_cross_reference “GOC:curators”

obsolete glutamate catabolic process to oxaloacetate `http://purl.obolibrary.org/obo/GO_0019554`

Removed

obsolete glutamate catabolic process to oxaloacetate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including oxaloacetate.”
- database_cross_reference “GOC:go_curators”

Added

obsolete glutamate catabolic process to oxaloacetate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including oxaloacetate.”
- database_cross_reference “GOC:curators”

obsolete glutamate catabolic process to succinate via succinate semialdehyde `http://purl.obolibrary.org/obo/GO_0019549`

Removed

obsolete glutamate catabolic process to succinate via succinate semialdehyde definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glutamate into succinate, that includes the conversion of 4-aminobutyrate to succinate semialdehyde by the pyruvate-dependent gamma aminobutyrate (GABA) transaminase.”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “MetaCyc:PWY-4321”

Added

obsolete glutamate catabolic process to succinate via succinate semialdehyde definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glutamate into succinate, that includes the conversion of 4-aminobutyrate to succinate semialdehyde by the pyruvate-dependent gamma aminobutyrate (GABA) transaminase.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:bf”
- database_cross_reference “MetaCyc:PWY-4321”

obsolete glutamate catabolic process via 2-oxoglutarate `http://purl.obolibrary.org/obo/GO_0006539`

Removed

obsolete glutamate catabolic process via 2-oxoglutarate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxoglutarate.”
- database_cross_reference “GOC:go_curators”
obsolete glutamate catabolic process via 2-oxoglutarate comment “The reason for obsoletion is that this term is equivalent to GO:0019552 glutamate catabolic process via 2-hydroxyglutarate, XREF the same MetaCyc pathway.”
obsolete glutamate catabolic process via 2-oxoglutarate term replaced by obsolete L-glutamate fermentation via 2-hydroxyglutarate

Added

obsolete glutamate catabolic process via 2-oxoglutarate comment “This term was obsoleted because it represents a specific instance of a pathway that should be captured as a GO-CAM model.”
obsolete glutamate catabolic process via 2-oxoglutarate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxoglutarate.”
- database_cross_reference “GOC:curators”

obsolete glutamate catabolic process via mesaconate and citramalate `http://purl.obolibrary.org/obo/GO_0019671`

Removed

obsolete glutamate catabolic process via mesaconate and citramalate comment “The reason for obsoletion is that this term is an unnecessary grouping term.”
obsolete glutamate catabolic process via mesaconate and citramalate consider obsolete L-glutamate fermentation to propionate
obsolete glutamate catabolic process via mesaconate and citramalate consider obsolete L-glutamate fermentation via L-citramalate

Added

obsolete glutamate catabolic process via mesaconate and citramalate comment “This term was obsoleted because it represents a specific instance of a pathway that should be captured as a GO-CAM model.”

obsolete glutamic-type endopeptidase activity `http://purl.obolibrary.org/obo/GO_0070007`

Removed

obsolete glutamic-type endopeptidase activity label “glutamic-type endopeptidase activity”
obsolete glutamic-type endopeptidase activity definition “Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad.”
- database_cross_reference “GOC:mah”
- database_cross_reference “https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE”
- database_cross_reference “https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE”
obsolete glutamic-type endopeptidase activity SubClassOf endopeptidase activity
obsolete glutamic-type endopeptidase activity SubClassOf glutamic-type peptidase activity

Added

obsolete glutamic-type endopeptidase activity definition “OBSOLETE. Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad.”
- database_cross_reference “GOC:mah”
- database_cross_reference “https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE”
- database_cross_reference “https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE”
obsolete glutamic-type endopeptidase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete glutamic-type endopeptidase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete glutamic-type endopeptidase activity deprecated true
obsolete glutamic-type endopeptidase activity label “obsolete glutamic-type endopeptidase activity”

obsolete glutamine biosynthetic process `http://purl.obolibrary.org/obo/GO_0006542`

Removed

obsolete glutamine biosynthetic process narrowMatch GLNSYN-PWY
obsolete glutamine biosynthetic process database_cross_reference “MetaCyc:GLNSYN-PWY”

obsolete glutamine catabolic process to fumarate `http://purl.obolibrary.org/obo/GO_0019460`

Removed

obsolete glutamine catabolic process to fumarate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glutamine into other compounds, including fumarate.”
- database_cross_reference “GOC:go_curators”

Added

obsolete glutamine catabolic process to fumarate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glutamine into other compounds, including fumarate.”
- database_cross_reference “GOC:curators”

obsolete glutamine family amino acid metabolic process `http://purl.obolibrary.org/obo/GO_0009064`

Removed

obsolete glutamine family amino acid metabolic process database_cross_reference “Reactome:R-HSA-8964539”
- label “Glutamate and glutamine metabolism”

obsolete glutaredoxin biosynthetic process `http://purl.obolibrary.org/obo/GO_0042965`

Removed

obsolete glutaredoxin biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of a small disulfide-containing redox protein that serves as a glutathione-disulfide oxidoreductase.”
- database_cross_reference “GOC:go_curators”

Added

obsolete glutaredoxin biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of a small disulfide-containing redox protein that serves as a glutathione-disulfide oxidoreductase.”
- database_cross_reference “GOC:curators”

obsolete glycine biosynthetic process from L-serine `http://purl.obolibrary.org/obo/GO_0019264`

Removed

obsolete glycine biosynthetic process from L-serine label “glycine biosynthetic process from L-serine”
obsolete glycine biosynthetic process from L-serine database_cross_reference “MetaCyc:GLYSYN-PWY”
obsolete glycine biosynthetic process from L-serine exactMatch GLYSYN-PWY
obsolete glycine biosynthetic process from L-serine definition “The chemical reactions and pathways resulting in the formation of glycine from L-serine.”
- database_cross_reference “MetaCyc:GLYSYN-PWY”
obsolete glycine biosynthetic process from L-serine SubClassOf glycine biosynthetic process
obsolete glycine biosynthetic process from L-serine SubClassOf L-serine metabolic process

Added

obsolete glycine biosynthetic process from L-serine comment “The reason for obsoletion is that this term represents a GO-CAM model.”
obsolete glycine biosynthetic process from L-serine label “obsolete glycine biosynthetic process from L-serine”
obsolete glycine biosynthetic process from L-serine term replaced by glycine biosynthetic process
obsolete glycine biosynthetic process from L-serine deprecated true
obsolete glycine biosynthetic process from L-serine definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of glycine from L-serine.”
- database_cross_reference “MetaCyc:GLYSYN-PWY”
obsolete glycine biosynthetic process from L-serine term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI

obsolete glycine biosynthetic process, by transamination of glyoxylate `http://purl.obolibrary.org/obo/GO_0019265`

Removed

obsolete glycine biosynthetic process, by transamination of glyoxylate database_cross_reference “MetaCyc:GLYSYN-ALA-PWY”
obsolete glycine biosynthetic process, by transamination of glyoxylate label “glycine biosynthetic process, by transamination of glyoxylate”
obsolete glycine biosynthetic process, by transamination of glyoxylate definition “The chemical reactions and pathways resulting in the formation of glycine by the transamination of glyoxylate.”
- database_cross_reference “MetaCyc:GLYSYN-ALA-PWY”
- database_cross_reference “GOC:go_curators”
obsolete glycine biosynthetic process, by transamination of glyoxylate exactMatch GLYSYN-ALA-PWY
obsolete glycine biosynthetic process, by transamination of glyoxylate SubClassOf glycine biosynthetic process

Added

obsolete glycine biosynthetic process, by transamination of glyoxylate definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of glycine by the transamination of glyoxylate.”
- database_cross_reference “GOC:curators”
- database_cross_reference “MetaCyc:GLYSYN-ALA-PWY”
obsolete glycine biosynthetic process, by transamination of glyoxylate deprecated true
obsolete glycine biosynthetic process, by transamination of glyoxylate comment “The reason for obsoletion is that this term represents a GO-CAM model.”
obsolete glycine biosynthetic process, by transamination of glyoxylate term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
obsolete glycine biosynthetic process, by transamination of glyoxylate term replaced by glycine biosynthetic process
obsolete glycine biosynthetic process, by transamination of glyoxylate label “obsolete glycine biosynthetic process, by transamination of glyoxylate”

obsolete glycine catabolic process to creatine `http://purl.obolibrary.org/obo/GO_0019463`

Removed

obsolete glycine catabolic process to creatine definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glycine into other compounds, including creatine.”
- database_cross_reference “GOC:go_curators”

Added

obsolete glycine catabolic process to creatine definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glycine into other compounds, including creatine.”
- database_cross_reference “GOC:curators”

obsolete guanine deglycation, methylglyoxal removal `http://purl.obolibrary.org/obo/GO_0106045`

Removed

obsolete guanine deglycation, methylglyoxal removal creation date “2017-08-01T18:17:28Z”
obsolete guanine deglycation, methylglyoxal removal created by “hjd”
obsolete guanine deglycation, methylglyoxal removal definition “The removal of methylglyoxal from a glycated guanine, to form lactate and a deglycated guanine.”
- database_cross_reference “PMID:28596309”
obsolete guanine deglycation, methylglyoxal removal label “guanine deglycation, methylglyoxal removal”
obsolete guanine deglycation, methylglyoxal removal SubClassOf response to methylglyoxal
obsolete guanine deglycation, methylglyoxal removal SubClassOf methylglyoxal metabolic process
obsolete guanine deglycation, methylglyoxal removal SubClassOf cellular detoxification of methylglyoxal
obsolete guanine deglycation, methylglyoxal removal SubClassOf guanine deglycation

Added

obsolete guanine deglycation, methylglyoxal removal term tracker item “https://github.com/geneontology/go-ontology/issues/31367”^^anyURI
obsolete guanine deglycation, methylglyoxal removal label “obsolete guanine deglycation, methylglyoxal removal”
obsolete guanine deglycation, methylglyoxal removal deprecated true
obsolete guanine deglycation, methylglyoxal removal comment “The reason for obsoletion is that this term represents a molecular function rather than a biological process.”
obsolete guanine deglycation, methylglyoxal removal definition “OBSOLETE. The removal of methylglyoxal from a glycated guanine, to form lactate and a deglycated guanine.”
- database_cross_reference “PMID:28596309”
obsolete guanine deglycation, methylglyoxal removal term replaced by protein deglycase activity

obsolete heavy metal sensitivity/resistance `http://purl.obolibrary.org/obo/GO_0009634`

Removed

obsolete heavy metal sensitivity/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete heavy metal sensitivity/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete hepoxilin A3 synthase activity `http://purl.obolibrary.org/obo/GO_0051120`

Removed

obsolete hepoxilin A3 synthase activity database_cross_reference “Reactome:R-HSA-8942208”
- label “ALOXE3 isomerises 12R-HpETE to HXA3”
obsolete hepoxilin A3 synthase activity database_cross_reference “Reactome:R-HSA-2161794”
- label “Arachidonate is converted to HXA3/B3 by ALOX12”

obsolete hepoxilin metabolic process `http://purl.obolibrary.org/obo/GO_0051121`

Removed

obsolete hepoxilin metabolic process database_cross_reference “Reactome:R-HSA-2142696”
- label “Synthesis of Hepoxilins (HX) and Trioxilins (TrX)”

obsolete herbicide susceptibility/resistance `http://purl.obolibrary.org/obo/GO_0019837`

Removed

obsolete herbicide susceptibility/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete herbicide susceptibility/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete heterolactic fermentation `http://purl.obolibrary.org/obo/GO_0019656`

Removed

obsolete heterolactic fermentation definition “The anaerobic chemical reactions and pathways resulting in the enzymatic breakdown of D-glucose to D-lactate and ethanol, yielding energy in the form of adenosine triphosphate (ATP) at the rate of one ATP per glucose molecule.”
- database_cross_reference “GOC:jl”
- database_cross_reference “MetaCyc:P122-PWY”
obsolete heterolactic fermentation database_cross_reference “MetaCyc:P122-PWY”
obsolete heterolactic fermentation label “heterolactic fermentation”
obsolete heterolactic fermentation SubClassOf obsolete glucose catabolic process to lactate
obsolete heterolactic fermentation SubClassOf ethanol metabolic process

Added

obsolete heterolactic fermentation term tracker item “https://github.com/geneontology/go-ontology/issues/31217”^^anyURI
obsolete heterolactic fermentation term replaced by pyruvate fermentation to lactate
obsolete heterolactic fermentation definition “OBSOLETE. The anaerobic chemical reactions and pathways resulting in the enzymatic breakdown of D-glucose to D-lactate and ethanol, yielding energy in the form of adenosine triphosphate (ATP) at the rate of one ATP per glucose molecule.”
- database_cross_reference “GOC:jl”
obsolete heterolactic fermentation deprecated true
obsolete heterolactic fermentation label “obsolete heterolactic fermentation”
obsolete heterolactic fermentation comment “The reason for obsoletion is that the term is not needed for fermentation process starting with pyruvate.”

obsolete heterotrimeric G-protein `http://purl.obolibrary.org/obo/GO_0005065`

Removed

obsolete heterotrimeric G-protein definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete heterotrimeric G-protein definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete hexagonal collagen network of basement membrane `http://purl.obolibrary.org/obo/GO_0140155`

Removed

obsolete hexagonal collagen network of basement membrane definition “Supramolecular structure formed by trimers of collagen VIII and found in the basement membrane.”
- database_cross_reference “PMID:21421911”
- database_cross_reference “PMID:3047147”
- database_cross_reference “PMID:2376131”
- database_cross_reference “PMID:31387942”
obsolete hexagonal collagen network of basement membrane label “hexagonal collagen network of basement membrane”
obsolete hexagonal collagen network of basement membrane SubClassOf complex of network-forming collagens
obsolete hexagonal collagen network of basement membrane SubClassOf part of some collagenous component of basement membrane

Added

obsolete hexagonal collagen network of basement membrane comment “This term was obsoleted because it is an uncessary grouping term. There is not sufficient evidence to show that collagen VIII is only located in the basement membrane in all organs and species.”
obsolete hexagonal collagen network of basement membrane term replaced by hexagonal collagen network
obsolete hexagonal collagen network of basement membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31492”^^anyURI
obsolete hexagonal collagen network of basement membrane definition “OBSOLETE. Supramolecular structure formed by trimers of collagen VIII and found in the basement membrane.”
- database_cross_reference “PMID:21421911”
- database_cross_reference “PMID:3047147”
- database_cross_reference “PMID:2376131”
- database_cross_reference “PMID:31387942”
obsolete hexagonal collagen network of basement membrane label “obsolete hexagonal collagen network of basement membrane”
obsolete hexagonal collagen network of basement membrane deprecated true

obsolete histidine family amino acid metabolic process `http://purl.obolibrary.org/obo/GO_0009075`

Removed

obsolete histidine family amino acid metabolic process term replaced by obsolete L-histidine metabolic process

obsolete holin `http://purl.obolibrary.org/obo/GO_0015832`

Removed

obsolete holin definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete holin definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete homolactic fermentation `http://purl.obolibrary.org/obo/GO_0019661`

Removed

obsolete homolactic fermentation database_cross_reference “MetaCyc:ANAEROFRUCAT-PWY”
obsolete homolactic fermentation definition “The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, via canonical glycolysis, yielding energy in the form of adenosine triphosphate (ATP).”
- database_cross_reference “GOC:jl”
obsolete homolactic fermentation label “homolactic fermentation”
obsolete homolactic fermentation SubClassOf has part some pyruvate fermentation to L(+)-lactate
obsolete homolactic fermentation SubClassOf has part some canonical glycolysis
obsolete homolactic fermentation SubClassOf obsolete glucose catabolic process to lactate

Added

obsolete homolactic fermentation term replaced by pyruvate fermentation to lactate
obsolete homolactic fermentation comment “The reason for obsoletion is that the term is not needed for fermentation process starting with pyruvate.”
obsolete homolactic fermentation deprecated true
obsolete homolactic fermentation term tracker item “https://github.com/geneontology/go-ontology/issues/31217”^^anyURI
obsolete homolactic fermentation definition “OBSOLETE. The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, via canonical glycolysis, yielding energy in the form of adenosine triphosphate (ATP).”
- database_cross_reference “GOC:jl”
obsolete homolactic fermentation label “obsolete homolactic fermentation”

obsolete hydrogen-transporting ATP synthase, coupling factor CF(0) `http://purl.obolibrary.org/obo/GO_0005755`

Removed

obsolete hydrogen-transporting ATP synthase, coupling factor CF(0) definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete hydrogen-transporting ATP synthase, coupling factor CF(0) definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete hydroxy-nicotine oxidase activity `http://purl.obolibrary.org/obo/GO_0019116`

Removed

obsolete hydroxy-nicotine oxidase activity definition “Catalysis of the reaction: 6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + hydrogen peroxide.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:16095622”
obsolete hydroxy-nicotine oxidase activity label “hydroxy-nicotine oxidase activity”
obsolete hydroxy-nicotine oxidase activity SubClassOf oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

Added

obsolete hydroxy-nicotine oxidase activity definition “OBSOLETE. Catalysis of the reaction: 6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + hydrogen peroxide.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:16095622”
obsolete hydroxy-nicotine oxidase activity consider (R)-6-hydroxynicotine oxidase activity
obsolete hydroxy-nicotine oxidase activity label “obsolete hydroxy-nicotine oxidase activity”
obsolete hydroxy-nicotine oxidase activity consider (S)-6-hydroxynicotine oxidase activity
obsolete hydroxy-nicotine oxidase activity comment “This term was obsoleted because it is an unnecessary grouping term.”
obsolete hydroxy-nicotine oxidase activity deprecated true

obsolete hypoglycin A gamma-glutamyl transpeptidase activity `http://purl.obolibrary.org/obo/GO_0102953`

Removed

obsolete hypoglycin A gamma-glutamyl transpeptidase activity definition “Catalysis of the reaction: glutathionate + hypoglycin A = L-cysteinylglycine + hypoglycin B.”
- database_cross_reference “GOC:pz”
obsolete hypoglycin A gamma-glutamyl transpeptidase activity database_cross_reference “MetaCyc:RXN-9157”
obsolete hypoglycin A gamma-glutamyl transpeptidase activity label “hypoglycin A gamma-glutamyl transpeptidase activity”
obsolete hypoglycin A gamma-glutamyl transpeptidase activity SubClassOf aminoacyltransferase activity

Added

obsolete hypoglycin A gamma-glutamyl transpeptidase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete hypoglycin A gamma-glutamyl transpeptidase activity deprecated true
obsolete hypoglycin A gamma-glutamyl transpeptidase activity definition “OBSOLETE. Catalysis of the reaction: glutathionate + hypoglycin A = L-cysteinylglycine + hypoglycin B.”
- database_cross_reference “GOC:pz”
obsolete hypoglycin A gamma-glutamyl transpeptidase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete hypoglycin A gamma-glutamyl transpeptidase activity label “obsolete hypoglycin A gamma-glutamyl transpeptidase activity”

obsolete hypusine metabolic process `http://purl.obolibrary.org/obo/GO_0046516`

Removed

obsolete hypusine metabolic process label “hypusine metabolic process”
obsolete hypusine metabolic process definition “The chemical reactions and pathways involving hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine.”
- database_cross_reference “GOC:ai”
obsolete hypusine metabolic process SubClassOf metabolic process

Added

obsolete hypusine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI
obsolete hypusine metabolic process label “obsolete hypusine metabolic process”
obsolete hypusine metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
obsolete hypusine metabolic process consider peptidyl-hypusine biosynthetic process
obsolete hypusine metabolic process deprecated true
obsolete hypusine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine.”
- database_cross_reference “GOC:ai”

obsolete induction by virus of host cell-cell fusion `http://purl.obolibrary.org/obo/GO_0006948`

Removed

obsolete induction by virus of host cell-cell fusion database_cross_reference “Reactome:R-HSA-9733458”
- label “Induction of Cell-Cell Fusion”

obsolete induction of apoptosis by p53 `http://purl.obolibrary.org/obo/GO_0006918`

Removed

obsolete induction of apoptosis by p53 definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete induction of apoptosis by p53 definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete inorganic diphosphate transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0030504`

Removed

obsolete inorganic diphosphate transmembrane transporter activity database_cross_reference “Reactome:R-HSA-5226964”
- label “ANKH transports PPi from cytosol to extracellular region”

obsolete inositol hexakisphosphate 2-phosphatase activity `http://purl.obolibrary.org/obo/GO_0052826`

Removed

obsolete inositol hexakisphosphate 2-phosphatase activity database_cross_reference “Reactome:R-HSA-1855225”
- label “IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen”

obsolete inositol-1,4,-bisphosphate 3-phosphatase `http://purl.obolibrary.org/obo/GO_0004442`

Removed

obsolete inositol-1,4,-bisphosphate 3-phosphatase definition “OBSOLETE. Catalysis of the reaction: D-myo-inositol 1,3-bisphosphate + H2O = D-myo-inositol 1-monophosphate + phosphate.”
- database_cross_reference “EC:3.1.3.65”
- database_cross_reference “GOC:go_curators”

Added

obsolete inositol-1,4,-bisphosphate 3-phosphatase definition “OBSOLETE. Catalysis of the reaction: D-myo-inositol 1,3-bisphosphate + H2O = D-myo-inositol 1-monophosphate + phosphate.”
- database_cross_reference “EC:3.1.3.65”
- database_cross_reference “GOC:curators”

obsolete inositol-1,4,-bisphosphate 4-phosphatase `http://purl.obolibrary.org/obo/GO_0004443`

Removed

obsolete inositol-1,4,-bisphosphate 4-phosphatase definition “OBSOLETE. Catalysis of the reaction: D-myo-inositol 3,4-bisphosphate + H2O = D-myo-inositol 3-monophosphate + phosphate.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “EC:3.1.3.66”

Added

obsolete inositol-1,4,-bisphosphate 4-phosphatase definition “OBSOLETE. Catalysis of the reaction: D-myo-inositol 3,4-bisphosphate + H2O = D-myo-inositol 3-monophosphate + phosphate.”
- database_cross_reference “GOC:curators”
- database_cross_reference “EC:3.1.3.66”

obsolete insecticide resistance `http://purl.obolibrary.org/obo/GO_0006806`

Removed

obsolete insecticide resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete insecticide resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete insecticide susceptibility/resistance `http://purl.obolibrary.org/obo/GO_0016352`

Removed

obsolete insecticide susceptibility/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete insecticide susceptibility/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete integral component of Golgi membrane `http://purl.obolibrary.org/obo/GO_0030173`

Removed

obsolete integral component of Golgi membrane definition “OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.”
- database_cross_reference “GOC:go_curators”

Added

obsolete integral component of Golgi membrane definition “OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.”
- database_cross_reference “GOC:curators”

obsolete integral component of cell outer membrane `http://purl.obolibrary.org/obo/GO_0045203`

Removed

obsolete integral component of cell outer membrane definition “OBSOLETE. The component of the cell outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_sensu”

Added

obsolete integral component of cell outer membrane definition “OBSOLETE. The component of the cell outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:mtg_sensu”

obsolete integral component of nuclear inner membrane `http://purl.obolibrary.org/obo/GO_0005639`

Removed

obsolete integral component of nuclear inner membrane definition “OBSOLETE. The component of the nuclear inner membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.”
- database_cross_reference “GOC:go_curators”

Added

obsolete integral component of nuclear inner membrane definition “OBSOLETE. The component of the nuclear inner membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.”
- database_cross_reference “GOC:curators”

obsolete integral component of synaptic vesicle membrane `http://purl.obolibrary.org/obo/GO_0030285`

Removed

obsolete integral component of synaptic vesicle membrane definition “OBSOLETE. The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:go_curators”

Added

obsolete integral component of synaptic vesicle membrane definition “OBSOLETE. The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:dos”

obsolete inward rectifier channel `http://purl.obolibrary.org/obo/GO_0005241`

Removed

obsolete inward rectifier channel definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete inward rectifier channel definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete isoleucine biosynthetic process `http://purl.obolibrary.org/obo/GO_0009097`

Removed

obsolete isoleucine biosynthetic process database_cross_reference “MetaCyc:ILEUSYN-PWY”
obsolete isoleucine biosynthetic process label “isoleucine biosynthetic process”
obsolete isoleucine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of isoleucine, (2R,3R)-2-amino-3-methylpentanoic acid.”
- database_cross_reference “GOC:ai”
obsolete isoleucine biosynthetic process SubClassOf branched-chain amino acid biosynthetic process
obsolete isoleucine biosynthetic process SubClassOf isoleucine metabolic process
obsolete isoleucine biosynthetic process SubClassOf alpha-amino acid biosynthetic process

Added

obsolete isoleucine biosynthetic process label “obsolete isoleucine biosynthetic process”
obsolete isoleucine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/30848”^^anyURI
obsolete isoleucine biosynthetic process deprecated true
obsolete isoleucine biosynthetic process comment “The reason for obsoletion is that more specific terms were created.”
obsolete isoleucine biosynthetic process term replaced by L-isoleucine biosynthetic process
obsolete isoleucine biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of isoleucine, (2R,3R)-2-amino-3-methylpentanoic acid.”
- database_cross_reference “GOC:ai”

obsolete juvenile hormone binding `http://purl.obolibrary.org/obo/GO_0006717`

Removed

obsolete juvenile hormone binding definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete juvenile hormone binding definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete killer activity `http://purl.obolibrary.org/obo/GO_0007583`

Removed

obsolete killer activity definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete killer activity definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete lactone transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0042971`

Removed

obsolete lactone transmembrane transporter activity definition “OBSOLETE. Enables the transfer of lactone from one side of a membrane to the other. A lactone is a cyclic ester of a hydroxy carboxylic acid, containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.”
- database_cross_reference “GOC:go_curators”

Added

obsolete lactone transmembrane transporter activity definition “OBSOLETE. Enables the transfer of lactone from one side of a membrane to the other. A lactone is a cyclic ester of a hydroxy carboxylic acid, containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.”
- database_cross_reference “GOC:curators”

obsolete lactone transport `http://purl.obolibrary.org/obo/GO_0042969`

Removed

obsolete lactone transport definition “OBSOLETE. The directed movement of lactone from one side of a membrane to the other. A lactone is a cyclic ester of a hydroxy carboxylic acid, containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.”
- database_cross_reference “GOC:go_curators”

Added

obsolete lactone transport definition “OBSOLETE. The directed movement of lactone from one side of a membrane to the other. A lactone is a cyclic ester of a hydroxy carboxylic acid, containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.”
- database_cross_reference “GOC:curators”

obsolete leukotriene C4 gamma-glutamyl transferase activity `http://purl.obolibrary.org/obo/GO_0103068`

Removed

obsolete leukotriene C4 gamma-glutamyl transferase activity database_cross_reference “MetaCyc:RXN66-336”
obsolete leukotriene C4 gamma-glutamyl transferase activity label “leukotriene C4 gamma-glutamyl transferase activity”
obsolete leukotriene C4 gamma-glutamyl transferase activity definition “Catalysis of the reaction: leukotriene C4 + a standard alpha amino acid = leukotriene D4 + an (gamma-L-glutamyl)-L-amino acid.”
- database_cross_reference “PMID:1676842”
- database_cross_reference “GOC:pz”
- database_cross_reference “PMID:9139674”
obsolete leukotriene C4 gamma-glutamyl transferase activity SubClassOf aminoacyltransferase activity

Added

obsolete leukotriene C4 gamma-glutamyl transferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31373”^^anyURI
obsolete leukotriene C4 gamma-glutamyl transferase activity label “obsolete leukotriene C4 gamma-glutamyl transferase activity”
obsolete leukotriene C4 gamma-glutamyl transferase activity deprecated true
obsolete leukotriene C4 gamma-glutamyl transferase activity definition “OBSOLETE. Catalysis of the reaction: leukotriene C4 + a standard alpha amino acid = leukotriene D4 + an (gamma-L-glutamyl)-L-amino acid.”
- database_cross_reference “PMID:1676842”
- database_cross_reference “GOC:pz”
- database_cross_reference “PMID:9139674”

obsolete lipid binding `http://purl.obolibrary.org/obo/GO_0006630`

Removed

obsolete lipid binding definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete lipid binding definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete lipoamide metabolic process `http://purl.obolibrary.org/obo/GO_0006748`

Removed

obsolete lipoamide metabolic process definition “OBSOLETE. The chemical reactions and pathways involving lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group.”
- database_cross_reference “GOC:go_curators”

Added

obsolete lipoamide metabolic process definition “OBSOLETE. The chemical reactions and pathways involving lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group.”
- database_cross_reference “GOC:curators”

obsolete low-density lipoprotein catabolic process `http://purl.obolibrary.org/obo/GO_0045192`

Removed

obsolete low-density lipoprotein catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of low-density lipoproteins, also known as beta lipoproteins, one of the classes of lipoproteins found in the bloodstream of animals, acting as a carrier for cholesterol and fats.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

obsolete low-density lipoprotein catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of low-density lipoproteins, also known as beta lipoproteins, one of the classes of lipoproteins found in the bloodstream of animals, acting as a carrier for cholesterol and fats.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

obsolete low-density lipoprotein particle receptor biosynthetic process `http://purl.obolibrary.org/obo/GO_0045713`

Removed

obsolete low-density lipoprotein particle receptor biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors, cell surface proteins that mediate the endocytosis of low-density lipoprotein particles by cells.”
- database_cross_reference “GOC:go_curators”

Added

obsolete low-density lipoprotein particle receptor biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors, cell surface proteins that mediate the endocytosis of low-density lipoprotein particles by cells.”
- database_cross_reference “GOC:curators”

obsolete lycopene cleavage oxygenase activity `http://purl.obolibrary.org/obo/GO_0102818`

Removed

obsolete lycopene cleavage oxygenase activity label “lycopene cleavage oxygenase activity”
obsolete lycopene cleavage oxygenase activity database_cross_reference “MetaCyc:RXN-8236”
obsolete lycopene cleavage oxygenase activity definition “Catalysis of the reaction: lycopene + 2 O2 = 2 sulcatone + bixin aldehyde.”
- database_cross_reference “GOC:pz”
- database_cross_reference “MetaCyc:RXN-8236”
obsolete lycopene cleavage oxygenase activity SubClassOf oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

Added

obsolete lycopene cleavage oxygenase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete lycopene cleavage oxygenase activity label “obsolete lycopene cleavage oxygenase activity”
obsolete lycopene cleavage oxygenase activity deprecated true
obsolete lycopene cleavage oxygenase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete lycopene cleavage oxygenase activity definition “OBSOLETE. Catalysis of the reaction: lycopene + 2 O2 = 2 sulcatone + bixin aldehyde.”
- database_cross_reference “GOC:pz”

obsolete lysine catabolic process `http://purl.obolibrary.org/obo/GO_0006554`

Removed

obsolete lysine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid.”
- database_cross_reference “GOC:go_curators”

Added

obsolete lysine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid.”
- database_cross_reference “GOC:curators”

obsolete lysine metabolic process `http://purl.obolibrary.org/obo/GO_0006553`

Removed

obsolete lysine metabolic process definition “The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid.”
- database_cross_reference “GOC:go_curators”
obsolete lysine metabolic process label “lysine metabolic process”
obsolete lysine metabolic process SubClassOf alpha-amino acid metabolic process

Added

obsolete lysine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI
obsolete lysine metabolic process label “obsolete lysine metabolic process”
obsolete lysine metabolic process consider L-lysine biosynthetic process
obsolete lysine metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
obsolete lysine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid.”
- database_cross_reference “GOC:curators”
obsolete lysine metabolic process consider L-lysine catabolic process
obsolete lysine metabolic process deprecated true

obsolete lysosomal membrane hydrogen-transporting ATPase `http://purl.obolibrary.org/obo/GO_0008245`

Removed

obsolete lysosomal membrane hydrogen-transporting ATPase definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete lysosomal membrane hydrogen-transporting ATPase definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete lytic viral life cycle `http://purl.obolibrary.org/obo/GO_0030068`

Removed

obsolete lytic viral life cycle definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete lytic viral life cycle definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete macrophage receptor activity `http://purl.obolibrary.org/obo/GO_0008019`

Removed

obsolete macrophage receptor activity definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete macrophage receptor activity definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete male-specific antibacterial peptide activity `http://purl.obolibrary.org/obo/GO_0003798`

Removed

obsolete male-specific antibacterial peptide activity definition “OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells, but which is only expressed in males.”
- database_cross_reference “GOC:go_curators”

Added

obsolete male-specific antibacterial peptide activity definition “OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells, but which is only expressed in males.”
- database_cross_reference “GOC:curators”

obsolete mannosyl-diinositol phosphorylceramide phospholipase activity `http://purl.obolibrary.org/obo/GO_0052715`

Removed

obsolete mannosyl-diinositol phosphorylceramide phospholipase activity label “mannosyl-diinositol phosphorylceramide phospholipase activity”
obsolete mannosyl-diinositol phosphorylceramide phospholipase activity definition “Catalysis of the reaction: mannosyl-diinositol phosphorylceramide + H2O = C26-phytoceramide + mannosyldiphosphorylinositol.”
- database_cross_reference “GOC:ai”
obsolete mannosyl-diinositol phosphorylceramide phospholipase activity SubClassOf inositol phosphorylceramide phospholipase activity

Added

obsolete mannosyl-diinositol phosphorylceramide phospholipase activity label “obsolete mannosyl-diinositol phosphorylceramide phospholipase activity”
obsolete mannosyl-diinositol phosphorylceramide phospholipase activity definition “OBSOLETE. Catalysis of the reaction: mannosyl-diinositol phosphorylceramide + H2O = C26-phytoceramide + mannosyldiphosphorylinositol.”
- database_cross_reference “GOC:ai”
obsolete mannosyl-diinositol phosphorylceramide phospholipase activity deprecated true
obsolete mannosyl-diinositol phosphorylceramide phospholipase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete mannosyl-diinositol phosphorylceramide phospholipase activity comment “This term was obsoleted because it represents a specific substrate.”

obsolete mating type region replication fork barrier binding `http://purl.obolibrary.org/obo/GO_1990943`

Removed

obsolete mating type region replication fork barrier binding definition “Binding to the replication fork barrier found in the mating type region of fission yeast.”
- database_cross_reference “PMID:18723894”
obsolete mating type region replication fork barrier binding label “mating type region replication fork barrier binding”
obsolete mating type region replication fork barrier binding SubClassOf replication fork barrier binding

Added

obsolete mating type region replication fork barrier binding term replaced by replication fork barrier binding
obsolete mating type region replication fork barrier binding deprecated true
obsolete mating type region replication fork barrier binding label “obsolete mating type region replication fork barrier binding”
obsolete mating type region replication fork barrier binding definition “OBSOLETE. Binding to the replication fork barrier found in the mating type region of fission yeast.”
- database_cross_reference “PMID:18723894”
obsolete mating type region replication fork barrier binding comment “This term was obsoleted because it represents a precomposed term.”
obsolete mating type region replication fork barrier binding term tracker item “https://github.com/geneontology/go-ontology/issues/31529”^^anyURI

obsolete mercuric sensitivity/resistance `http://purl.obolibrary.org/obo/GO_0019832`

Removed

obsolete mercuric sensitivity/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete mercuric sensitivity/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity `http://purl.obolibrary.org/obo/GO_0004486`

Removed

obsolete methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity database_cross_reference “Reactome:R-HSA-200718”
- label “MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG”
obsolete methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity database_cross_reference “Reactome:R-HSA-200644”
- label “5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+”

obsolete methylselenocysteine deselenhydrase activity `http://purl.obolibrary.org/obo/GO_0098607`

Removed

obsolete methylselenocysteine deselenhydrase activity term tracker item “https://github.com/geneontology/go-ontology/issues/30815”^^anyURI
obsolete methylselenocysteine deselenhydrase activity label “methylselenocysteine deselenhydrase activity”
obsolete methylselenocysteine deselenhydrase activity definition “Catalysis of the reaction: Se-Methyl-L-selenocysteine + H2O = pyruvic acid + NH3 + Methaneselenol.”
- database_cross_reference “PMID:17451884”
- database_cross_reference “PMID:20383543”
obsolete methylselenocysteine deselenhydrase activity SubClassOf carbon-sulfur lyase activity

Added

obsolete methylselenocysteine deselenhydrase activity label “obsolete methylselenocysteine deselenhydrase activity”
obsolete methylselenocysteine deselenhydrase activity deprecated true
obsolete methylselenocysteine deselenhydrase activity definition “OBSOLETE. Catalysis of the reaction: Se-Methyl-L-selenocysteine + H2O = pyruvic acid + NH3 + Methaneselenol.”
- database_cross_reference “PMID:17451884”
- database_cross_reference “PMID:20383543”
obsolete methylselenocysteine deselenhydrase activity comment “This term was obsoleted because there is no evidence that this reaction exists.”
obsolete methylselenocysteine deselenhydrase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31530”^^anyURI

obsolete modulation by virus of host cellular process `http://purl.obolibrary.org/obo/GO_0019054`

Removed

obsolete modulation by virus of host cellular process database_cross_reference “Reactome:R-HSA-9833110”
- label “RSV-host interactions”
obsolete modulation by virus of host cellular process database_cross_reference “Reactome:R-HSA-168276”
- label “NS1 Mediated Effects on Host Pathways”

obsolete molecular function `http://purl.obolibrary.org/obo/GO_0008369`

Removed

obsolete molecular function definition “OBSOLETE. These are terms that have been removed from the active function ontology.”
- database_cross_reference “GOC:go_curators”

Added

obsolete molecular function definition “OBSOLETE. These are terms that have been removed from the active function ontology.”
- database_cross_reference “GOC:curators”

obsolete multi-organism signaling `http://purl.obolibrary.org/obo/GO_0035636`

Removed

obsolete multi-organism signaling definition “OBSOLETE. The transfer of information between living organisms.”
- database_cross_reference “GOC:go_curators”

Added

obsolete multi-organism signaling definition “OBSOLETE. The transfer of information between living organisms.”
- database_cross_reference “GOC:curators”

obsolete multicellular organismal signaling `http://purl.obolibrary.org/obo/GO_0035637`

Removed

obsolete multicellular organismal signaling definition “OBSOLETE. The transfer of information occurring at the level of a multicellular organism.”
- database_cross_reference “GOC:go_curators”

Added

obsolete multicellular organismal signaling definition “OBSOLETE. The transfer of information occurring at the level of a multicellular organism.”
- database_cross_reference “GOC:curators”

obsolete myopalladin binding `http://purl.obolibrary.org/obo/GO_0043411`

Removed

obsolete myopalladin binding definition “OBSOLETE. Binding to myopalladin, a myofibrillar protein with titin-like Ig domains.”
- database_cross_reference “GOC:go_curators”

Added

obsolete myopalladin binding definition “OBSOLETE. Binding to myopalladin, a myofibrillar protein with titin-like Ig domains.”
- database_cross_reference “GOC:curators”

obsolete negative regulation of CD4 production `http://purl.obolibrary.org/obo/GO_0045225`

Removed

obsolete negative regulation of CD4 production definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of CD4 production definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.”
- database_cross_reference “GOC:curators”

obsolete negative regulation of FasL production `http://purl.obolibrary.org/obo/GO_0045221`

Removed

obsolete negative regulation of FasL production definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL.”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of FasL production definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL.”
- database_cross_reference “GOC:curators”

obsolete negative regulation of Golgi lumen acidification `http://purl.obolibrary.org/obo/GO_1905527`

Removed

obsolete negative regulation of Golgi lumen acidification label “negative regulation of Golgi lumen acidification”
obsolete negative regulation of Golgi lumen acidification definition “Any process that stops, prevents or reduces the frequency, rate or extent of Golgi lumen acidification.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:23447592”
- database_cross_reference “GO_REF:0000058”
obsolete negative regulation of Golgi lumen acidification EquivalentTo biological regulation and (negatively regulates some Golgi lumen acidification)
obsolete negative regulation of Golgi lumen acidification SubClassOf negatively regulates some Golgi lumen acidification
obsolete negative regulation of Golgi lumen acidification SubClassOf obsolete regulation of Golgi lumen acidification
obsolete negative regulation of Golgi lumen acidification SubClassOf obsolete negative regulation of cellular pH reduction

Added

obsolete negative regulation of Golgi lumen acidification label “obsolete negative regulation of Golgi lumen acidification”
obsolete negative regulation of Golgi lumen acidification term replaced by Golgi lumen acidification
obsolete negative regulation of Golgi lumen acidification comment “This term was added in error. Regulating regulation is redundant.”
obsolete negative regulation of Golgi lumen acidification definition “OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of Golgi lumen acidification.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:23447592”
- database_cross_reference “GO_REF:0000058”
obsolete negative regulation of Golgi lumen acidification deprecated true
obsolete negative regulation of Golgi lumen acidification term tracker item “https://github.com/geneontology/go-ontology/issues/29164”^^anyURI

obsolete negative regulation of S phase of mitotic cell cycle `http://purl.obolibrary.org/obo/GO_0045749`

Removed

obsolete negative regulation of S phase of mitotic cell cycle definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of S phase of mitotic cell cycle activity.”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of S phase of mitotic cell cycle definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of S phase of mitotic cell cycle activity.”
- database_cross_reference “GOC:curators”

obsolete negative regulation of TRAIL receptor 1 biosynthetic process `http://purl.obolibrary.org/obo/GO_0045565`

Removed

obsolete negative regulation of TRAIL receptor 1 biosynthetic process definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1.”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of TRAIL receptor 1 biosynthetic process definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1.”
- database_cross_reference “GOC:curators”

obsolete negative regulation of TRAIL receptor 2 biosynthetic process `http://purl.obolibrary.org/obo/GO_0045567`

Removed

obsolete negative regulation of TRAIL receptor 2 biosynthetic process definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2.”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of TRAIL receptor 2 biosynthetic process definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2.”
- database_cross_reference “GOC:curators”

obsolete negative regulation of TRAIL receptor biosynthetic process `http://purl.obolibrary.org/obo/GO_0045563`

Removed

obsolete negative regulation of TRAIL receptor biosynthetic process definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor.”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of TRAIL receptor biosynthetic process definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor.”
- database_cross_reference “GOC:curators”

obsolete negative regulation of actin polymerization and/or depolymerization `http://purl.obolibrary.org/obo/GO_0045757`

Removed

obsolete negative regulation of actin polymerization and/or depolymerization definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization and/or depolymerization.”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of actin polymerization and/or depolymerization definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization and/or depolymerization.”
- database_cross_reference “GOC:curators”

obsolete negative regulation of anti-apoptosis `http://purl.obolibrary.org/obo/GO_0019987`

Removed

obsolete negative regulation of anti-apoptosis definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of anti-apoptosis.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_apoptosis”

Added

obsolete negative regulation of anti-apoptosis definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of anti-apoptosis.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_apoptosis”

obsolete negative regulation of calcium in ER `http://purl.obolibrary.org/obo/GO_0045783`

Removed

obsolete negative regulation of calcium in ER definition “OBSOLETE. Any process that reduces the concentration of calcium in the ER.”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of calcium in ER definition “OBSOLETE. Any process that reduces the concentration of calcium in the ER.”
- database_cross_reference “GOC:curators”

obsolete negative regulation of catecholamine metabolic process `http://purl.obolibrary.org/obo/GO_0045914`

Removed

obsolete negative regulation of catecholamine metabolic process definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine.”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of catecholamine metabolic process definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine.”
- database_cross_reference “GOC:curators”

obsolete negative regulation of cellular pH reduction `http://purl.obolibrary.org/obo/GO_0032848`

Removed

obsolete negative regulation of cellular pH reduction definition “Any process that stops, prevents, or reduces the frequency, rate, or extent of a process that reduces the internal pH of a cell.”
- database_cross_reference “GOC:mah”
obsolete negative regulation of cellular pH reduction has_exact_synonym “negative regulation of intracellular pH reduction”
obsolete negative regulation of cellular pH reduction label “negative regulation of cellular pH reduction”
obsolete negative regulation of cellular pH reduction has_exact_synonym “downregulation of cellular pH reduction”
obsolete negative regulation of cellular pH reduction has_narrow_synonym “inhibition of cellular pH reduction”
obsolete negative regulation of cellular pH reduction has_exact_synonym “negative regulation of reduction of pH in cell”
obsolete negative regulation of cellular pH reduction has_related_synonym “negative regulation of intracellular acidification”
obsolete negative regulation of cellular pH reduction has_exact_synonym “down-regulation of cellular pH reduction”
obsolete negative regulation of cellular pH reduction has_exact_synonym “negative regulation of reduction of cellular pH”
obsolete negative regulation of cellular pH reduction has_exact_synonym “negative regulation of cellular acidification”
obsolete negative regulation of cellular pH reduction has_exact_synonym “negative regulation of cell pH reduction”
obsolete negative regulation of cellular pH reduction has_exact_synonym “down regulation of cellular pH reduction”
obsolete negative regulation of cellular pH reduction EquivalentTo biological regulation and (negatively regulates some intracellular pH reduction)
obsolete negative regulation of cellular pH reduction SubClassOf negative regulation of biological process
obsolete negative regulation of cellular pH reduction SubClassOf negatively regulates some intracellular pH reduction
obsolete negative regulation of cellular pH reduction SubClassOf obsolete regulation of cellular pH reduction

Added

obsolete negative regulation of cellular pH reduction comment “This term was obsoleted because it represents ‘regulation of regulation’, which is redundant with direct pH regulation terms.”
obsolete negative regulation of cellular pH reduction deprecated true
obsolete negative regulation of cellular pH reduction term tracker item “https://github.com/geneontology/go-ontology/issues/29164”^^anyURI
obsolete negative regulation of cellular pH reduction definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate, or extent of a process that reduces the internal pH of a cell.”
- database_cross_reference “GOC:mah”
obsolete negative regulation of cellular pH reduction label “obsolete negative regulation of cellular pH reduction”
obsolete negative regulation of cellular pH reduction term replaced by intracellular pH elevation

obsolete negative regulation of cysteine-type endopeptidase activity involved in apoptotic process `http://purl.obolibrary.org/obo/GO_0043154`

Removed

obsolete negative regulation of cysteine-type endopeptidase activity involved in apoptotic process database_cross_reference “Reactome:R-HSA-5218900”
- label “CASP8 activity is inhibited”

obsolete negative regulation of cytoskeleton `http://purl.obolibrary.org/obo/GO_0045802`

Removed

obsolete negative regulation of cytoskeleton definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton.”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of cytoskeleton definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton.”
- database_cross_reference “GOC:curators”

obsolete negative regulation of ecdysteroid metabolic process `http://purl.obolibrary.org/obo/GO_0045965`

Removed

obsolete negative regulation of ecdysteroid metabolic process definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids.”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of ecdysteroid metabolic process definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids.”
- database_cross_reference “GOC:curators”

obsolete negative regulation of flagellum assembly `http://purl.obolibrary.org/obo/GO_0045718`

Removed

obsolete negative regulation of flagellum assembly definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a flagellum.”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of flagellum assembly definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a flagellum.”
- database_cross_reference “GOC:curators”

obsolete negative regulation of glutamate metabolic process `http://purl.obolibrary.org/obo/GO_2000212`

Removed

obsolete negative regulation of glutamate metabolic process label “negative regulation of glutamate metabolic process”
obsolete negative regulation of glutamate metabolic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of glutamate metabolic process.”
- database_cross_reference “GOC:sl”
obsolete negative regulation of glutamate metabolic process EquivalentTo biological regulation and (negatively regulates some glutamate metabolic process)
obsolete negative regulation of glutamate metabolic process SubClassOf negative regulation of small molecule metabolic process
obsolete negative regulation of glutamate metabolic process SubClassOf obsolete regulation of glutamate metabolic process
obsolete negative regulation of glutamate metabolic process SubClassOf negatively regulates some glutamate metabolic process
obsolete negative regulation of glutamate metabolic process SubClassOf negative regulation of amino acid metabolic process

Added

obsolete negative regulation of glutamate metabolic process comment “The reason for obsoletion is that this term was an unnecessary grouping terms and only ‘biosynthetic’ or ‘catabolic’ process should be used.”
obsolete negative regulation of glutamate metabolic process definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of glutamate metabolic process.”
- database_cross_reference “GOC:sl”
obsolete negative regulation of glutamate metabolic process label “obsolete negative regulation of glutamate metabolic process”
obsolete negative regulation of glutamate metabolic process deprecated true
obsolete negative regulation of glutamate metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31171”^^anyURI

obsolete negative regulation of initiation of acetate catabolic process by acetate `http://purl.obolibrary.org/obo/GO_0045755`

Removed

obsolete negative regulation of initiation of acetate catabolic process by acetate definition “OBSOLETE. Any process that stops or prevents the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate.”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of initiation of acetate catabolic process by acetate definition “OBSOLETE. Any process that stops or prevents the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate.”
- database_cross_reference “GOC:curators”

obsolete negative regulation of intermediate filament polymerization and/or depolymerization `http://purl.obolibrary.org/obo/GO_0045825`

Removed

obsolete negative regulation of intermediate filament polymerization and/or depolymerization definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament polymerization and/or depolymerization.”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of intermediate filament polymerization and/or depolymerization definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament polymerization and/or depolymerization.”
- database_cross_reference “GOC:curators”

obsolete negative regulation of light-activated channel activity `http://purl.obolibrary.org/obo/GO_0045831`

Removed

obsolete negative regulation of light-activated channel activity definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of light-activated channel activity.”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of light-activated channel activity definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of light-activated channel activity.”
- database_cross_reference “GOC:curators”

obsolete negative regulation of low-density lipoprotein particle receptor biosynthetic process `http://purl.obolibrary.org/obo/GO_0045715`

Removed

obsolete negative regulation of low-density lipoprotein particle receptor biosynthetic process definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein particle receptors.”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of low-density lipoprotein particle receptor biosynthetic process definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein particle receptors.”
- database_cross_reference “GOC:curators”

obsolete negative regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine `http://purl.obolibrary.org/obo/GO_2001195`

Removed

obsolete negative regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine definition “Any process that stops, prevents or reduces the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine.”
- database_cross_reference “GOC:obol”
obsolete negative regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine label “negative regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine”
obsolete negative regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine EquivalentTo biological regulation and (negatively regulates some obsolete L-lysine biosynthetic process via alpha-aminoadipate and saccharopine)
obsolete negative regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine SubClassOf negatively regulates some obsolete L-lysine biosynthetic process via alpha-aminoadipate and saccharopine
obsolete negative regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine SubClassOf obsolete negative regulation of lysine biosynthetic process via aminoadipic acid
obsolete negative regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine SubClassOf obsolete regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine

Added

obsolete negative regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine label “obsolete negative regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine”
obsolete negative regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine comment “The reason for obsoletion is that this term was created unnecessarily.”
obsolete negative regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
obsolete negative regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine deprecated true
obsolete negative regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine definition “OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine.”
- database_cross_reference “GOC:obol”

obsolete negative regulation of lysine biosynthetic process via aminoadipic acid `http://purl.obolibrary.org/obo/GO_1902987`

Removed

obsolete negative regulation of lysine biosynthetic process via aminoadipic acid definition “Any process that stops, prevents or reduces the frequency, rate or extent of lysine biosynthetic process via aminoadipic acid.”
- database_cross_reference “PMID:8590464”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “GO_REF:0000058”
obsolete negative regulation of lysine biosynthetic process via aminoadipic acid label “negative regulation of lysine biosynthetic process via aminoadipic acid”
obsolete negative regulation of lysine biosynthetic process via aminoadipic acid EquivalentTo biological regulation and (negatively regulates some obsolete L-lysine biosynthetic process via aminoadipic acid)
obsolete negative regulation of lysine biosynthetic process via aminoadipic acid SubClassOf negatively regulates some obsolete L-lysine biosynthetic process via aminoadipic acid
obsolete negative regulation of lysine biosynthetic process via aminoadipic acid SubClassOf negative regulation of amino acid biosynthetic process
obsolete negative regulation of lysine biosynthetic process via aminoadipic acid SubClassOf regulation of lysine biosynthetic process via aminoadipic acid
obsolete negative regulation of lysine biosynthetic process via aminoadipic acid SubClassOf negative regulation of small molecule metabolic process

Added

obsolete negative regulation of lysine biosynthetic process via aminoadipic acid label “obsolete negative regulation of lysine biosynthetic process via aminoadipic acid”
obsolete negative regulation of lysine biosynthetic process via aminoadipic acid comment “The reason for obsoletion is that this term was created unnecessarily.”
obsolete negative regulation of lysine biosynthetic process via aminoadipic acid deprecated true
obsolete negative regulation of lysine biosynthetic process via aminoadipic acid definition “OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of lysine biosynthetic process via aminoadipic acid.”
- database_cross_reference “PMID:8590464”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “GO_REF:0000058”
obsolete negative regulation of lysine biosynthetic process via aminoadipic acid term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI

obsolete negative regulation of molecular function, epigenetic `http://purl.obolibrary.org/obo/GO_0045857`

Removed

obsolete negative regulation of molecular function, epigenetic definition “OBSOLETE. Any heritable epigenetic process that stops, prevents, or reduces the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich (‘prion’) domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

obsolete negative regulation of molecular function, epigenetic definition “OBSOLETE. Any heritable epigenetic process that stops, prevents, or reduces the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich (‘prion’) domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

obsolete negative regulation of myosin light chain kinase activity `http://purl.obolibrary.org/obo/GO_0035506`

Removed

obsolete negative regulation of myosin light chain kinase activity definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of myosin light chain kinase activity.”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of myosin light chain kinase activity definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of myosin light chain kinase activity.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:bf”

obsolete negative regulation of myosin-light-chain-phosphatase activity `http://purl.obolibrary.org/obo/GO_0035509`

Removed

obsolete negative regulation of myosin-light-chain-phosphatase activity definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of myosin-light-chain-phosphatase activity.”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of myosin-light-chain-phosphatase activity definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of myosin-light-chain-phosphatase activity.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:bf”

obsolete negative regulation of nitric oxide mediated signal transduction `http://purl.obolibrary.org/obo/GO_0010751`

Removed

obsolete negative regulation of nitric oxide mediated signal transduction label “negative regulation of nitric oxide mediated signal transduction”
obsolete negative regulation of nitric oxide mediated signal transduction has_exact_synonym “negative regulation of nitric oxide-mediated signal transduction”
obsolete negative regulation of nitric oxide mediated signal transduction definition “Any process that decreases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO).”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:BHF”
obsolete negative regulation of nitric oxide mediated signal transduction EquivalentTo biological regulation and (negatively regulates some obsolete nitric oxide mediated signal transduction)
obsolete negative regulation of nitric oxide mediated signal transduction SubClassOf negative regulation of intracellular signal transduction
obsolete negative regulation of nitric oxide mediated signal transduction SubClassOf negatively regulates some obsolete nitric oxide mediated signal transduction
obsolete negative regulation of nitric oxide mediated signal transduction SubClassOf obsolete regulation of nitric oxide mediated signal transduction

Added

obsolete negative regulation of nitric oxide mediated signal transduction term tracker item “https://github.com/geneontology/go-ontology/issues/26613”^^anyURI
obsolete negative regulation of nitric oxide mediated signal transduction definition “OBSOLETE. Any process that decreases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO).”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:BHF”
obsolete negative regulation of nitric oxide mediated signal transduction label “obsolete negative regulation of nitric oxide mediated signal transduction”
obsolete negative regulation of nitric oxide mediated signal transduction comment “The reason for obsoletion is that this term has been inconsistently used and NO signaling proceeds via cGMP, so the more specific replacement term is preferred.”
obsolete negative regulation of nitric oxide mediated signal transduction term replaced by negative regulation of nitric oxide-cGMP mediated signal transduction
obsolete negative regulation of nitric oxide mediated signal transduction deprecated true

obsolete negative regulation of pteridine metabolic process `http://purl.obolibrary.org/obo/GO_0045863`

Removed

obsolete negative regulation of pteridine metabolic process definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving pteridine.”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of pteridine metabolic process definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving pteridine.”
- database_cross_reference “GOC:curators”

obsolete negative regulation of recombination within rDNA repeats `http://purl.obolibrary.org/obo/GO_0000020`

Removed

obsolete negative regulation of recombination within rDNA repeats definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

obsolete negative regulation of recombination within rDNA repeats definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

obsolete negative regulation of rhodopsin gene expression `http://purl.obolibrary.org/obo/GO_0045871`

Removed

obsolete negative regulation of rhodopsin gene expression definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of rhodopsin gene expression.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

obsolete negative regulation of rhodopsin gene expression definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of rhodopsin gene expression.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

obsolete negative regulation of survival gene product expression `http://purl.obolibrary.org/obo/GO_0008634`

Removed

obsolete negative regulation of survival gene product expression definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:mtg_apoptosis”

Added

obsolete negative regulation of survival gene product expression definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:mtg_apoptosis”

obsolete negative regulation of transcription by competitive promoter binding `http://purl.obolibrary.org/obo/GO_0010944`

Removed

obsolete negative regulation of transcription by competitive promoter binding definition “Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves direct competition for interaction with a promoter binding site.”
- database_cross_reference “GOC:tb”
obsolete negative regulation of transcription by competitive promoter binding label “negative regulation of transcription by competitive promoter binding”
obsolete negative regulation of transcription by competitive promoter binding SubClassOf negative regulation of DNA-templated transcription

Added

obsolete negative regulation of transcription by competitive promoter binding deprecated true
obsolete negative regulation of transcription by competitive promoter binding label “obsolete negative regulation of transcription by competitive promoter binding”
obsolete negative regulation of transcription by competitive promoter binding comment “This term was obsoleted because it represents a mechanism and is outside the scope of GO.”
obsolete negative regulation of transcription by competitive promoter binding term replaced by negative regulation of DNA-templated transcription
obsolete negative regulation of transcription by competitive promoter binding definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves direct competition for interaction with a promoter binding site.”
- database_cross_reference “GOC:tb”
obsolete negative regulation of transcription by competitive promoter binding term tracker item “https://github.com/geneontology/go-ontology/issues/19894”^^anyURI

obsolete negative regulation of transcription by pheromones `http://purl.obolibrary.org/obo/GO_0045996`

Removed

obsolete negative regulation of transcription by pheromones definition “OBSOLETE. Any process involving pheromones that stops, prevents or reduces the rate of transcription.”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of transcription by pheromones definition “OBSOLETE. Any process involving pheromones that stops, prevents or reduces the rate of transcription.”
- database_cross_reference “GOC:curators”

obsolete negative regulation of transcription during mitotic cell cycle `http://purl.obolibrary.org/obo/GO_0007068`

Removed

obsolete negative regulation of transcription during mitotic cell cycle definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription that occurs during the mitotic cell cycle.”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of transcription during mitotic cell cycle definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription that occurs during the mitotic cell cycle.”
- database_cross_reference “GOC:curators”

obsolete negative regulation of transcription from RNA polymerase I promoter during mitotic cell cycle `http://purl.obolibrary.org/obo/GO_0007069`

Removed

obsolete negative regulation of transcription from RNA polymerase I promoter during mitotic cell cycle definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase I promoter that occurs during the mitotic cell cycle.”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of transcription from RNA polymerase I promoter during mitotic cell cycle definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase I promoter that occurs during the mitotic cell cycle.”
- database_cross_reference “GOC:curators”

obsolete negative regulation of transcription from RNA polymerase II promoter by pheromones `http://purl.obolibrary.org/obo/GO_0046020`

Removed

obsolete negative regulation of transcription from RNA polymerase II promoter by pheromones definition “OBSOLETE. Any process involving pheromones that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter.”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of transcription from RNA polymerase II promoter by pheromones definition “OBSOLETE. Any process involving pheromones that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter.”
- database_cross_reference “GOC:curators”

obsolete negative regulation of transcription from RNA polymerase II promoter during mitotic cell cycle `http://purl.obolibrary.org/obo/GO_0007070`

Removed

obsolete negative regulation of transcription from RNA polymerase II promoter during mitotic cell cycle definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter that occurs during the mitotic cell cycle.”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of transcription from RNA polymerase II promoter during mitotic cell cycle definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter that occurs during the mitotic cell cycle.”
- database_cross_reference “GOC:curators”

obsolete negative regulation of transcription from RNA polymerase III promoter during mitotic cell cycle `http://purl.obolibrary.org/obo/GO_0007071`

Removed

obsolete negative regulation of transcription from RNA polymerase III promoter during mitotic cell cycle definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter that occurs during the mitotic cell cycle.”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of transcription from RNA polymerase III promoter during mitotic cell cycle definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter that occurs during the mitotic cell cycle.”
- database_cross_reference “GOC:curators”

obsolete negative regulation of transcription of homeotic gene (Polycomb group) `http://purl.obolibrary.org/obo/GO_0006340`

Removed

obsolete negative regulation of transcription of homeotic gene (Polycomb group) definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription of homeotic genes of the Polycomb group.”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of transcription of homeotic gene (Polycomb group) definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription of homeotic genes of the Polycomb group.”
- database_cross_reference “GOC:curators”

obsolete negative regulation of transcription of homeotic gene (trithorax group) `http://purl.obolibrary.org/obo/GO_0045891`

Removed

obsolete negative regulation of transcription of homeotic gene (trithorax group) definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription of homeotic genes of the trithorax group.”
- database_cross_reference “GOC:go_curators”

Added

obsolete negative regulation of transcription of homeotic gene (trithorax group) definition “OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription of homeotic genes of the trithorax group.”
- database_cross_reference “GOC:curators”

obsolete neprilysin activity `http://purl.obolibrary.org/obo/GO_0004245`

Removed

obsolete neprilysin activity definition “OBSOLETE. Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides.”
- database_cross_reference “GOC:curator”

Added

obsolete neprilysin activity definition “OBSOLETE. Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides.”
- database_cross_reference “GOC:curators”

obsolete neurotransmitter biosynthetic process and storage `http://purl.obolibrary.org/obo/GO_0001506`

Removed

obsolete neurotransmitter biosynthetic process and storage definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of neurotransmitters and the storage of the synthesized molecules.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0123668387”

Added

obsolete neurotransmitter biosynthetic process and storage definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of neurotransmitters and the storage of the synthesized molecules.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0123668387”

obsolete neurotransmitter receptor metabolic process `http://purl.obolibrary.org/obo/GO_0045213`

Removed

obsolete neurotransmitter receptor metabolic process definition “OBSOLETE. The chemical reactions and pathways involving neurotransmitter receptors.”
- database_cross_reference “GOC:go_curators”

Added

obsolete neurotransmitter receptor metabolic process definition “OBSOLETE. The chemical reactions and pathways involving neurotransmitter receptors.”
- database_cross_reference “GOC:curators”

obsolete nicotianamine catabolic process `http://purl.obolibrary.org/obo/GO_0030419`

Removed

obsolete nicotianamine catabolic process label “nicotianamine catabolic process”
obsolete nicotianamine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of nicotianamine, 2(S),3’2(S),3’‘(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid.”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:10069850”
obsolete nicotianamine catabolic process SubClassOf amino acid catabolic process
obsolete nicotianamine catabolic process SubClassOf biogenic amine catabolic process
obsolete nicotianamine catabolic process SubClassOf tricarboxylic acid catabolic process

Added

obsolete nicotianamine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of nicotianamine, 2(S),3’2(S),3’‘(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid.”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:10069850”
obsolete nicotianamine catabolic process deprecated true
obsolete nicotianamine catabolic process comment “This term was obsoleted because there is no evidence that a specific pathway for nicotianamine degradation exists.”
obsolete nicotianamine catabolic process label “obsolete nicotianamine catabolic process”
obsolete nicotianamine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31361”^^anyURI

obsolete nicotinate nucleotide biosynthetic process from tryptophan `http://purl.obolibrary.org/obo/GO_0019356`

Removed

obsolete nicotinate nucleotide biosynthetic process from tryptophan definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of nicotinate nucleotide from other compounds, including tryptophan.”
- database_cross_reference “GOC:go_curators”

Added

obsolete nicotinate nucleotide biosynthetic process from tryptophan definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of nicotinate nucleotide from other compounds, including tryptophan.”
- database_cross_reference “GOC:curators”

obsolete nitric oxide mediated signal transduction `http://purl.obolibrary.org/obo/GO_0007263`

Removed

obsolete nitric oxide mediated signal transduction definition “An intracellular signaling cassette that starts with production of nitric oxide, detection by receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and ends with the activation of downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:21549190”
obsolete nitric oxide mediated signal transduction label “nitric oxide mediated signal transduction”
obsolete nitric oxide mediated signal transduction has_exact_synonym “NO mediated signal transduction”
obsolete nitric oxide mediated signal transduction has_exact_synonym “nitric oxide-mediated signal transduction”
obsolete nitric oxide mediated signal transduction has_exact_synonym “NO-mediated signal transduction”
obsolete nitric oxide mediated signal transduction has_exact_synonym “nitric oxide signaling”
- database_cross_reference “GOC:bf”
obsolete nitric oxide mediated signal transduction SubClassOf intracellular signaling cassette

Added

obsolete nitric oxide mediated signal transduction definition “OBSOLETE. An intracellular signaling cassette that starts with production of nitric oxide, detection by receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and ends with the activation of downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:21549190”
obsolete nitric oxide mediated signal transduction term tracker item “https://github.com/geneontology/go-ontology/issues/26613”^^anyURI
obsolete nitric oxide mediated signal transduction label “obsolete nitric oxide mediated signal transduction”
obsolete nitric oxide mediated signal transduction deprecated true
obsolete nitric oxide mediated signal transduction comment “The reason for obsoletion is that this term has been inconsistently used and NO signaling proceeds via cGMP, so the more specific replacement term is preferred.”
obsolete nitric oxide mediated signal transduction term replaced by nitric oxide-cGMP-mediated signaling

obsolete nitroglycerin reductase activity `http://purl.obolibrary.org/obo/GO_0018547`

Removed

obsolete nitroglycerin reductase activity database_cross_reference “Reactome:R-HSA-9620103”
- label “ALDH2 transforms GTN to NO”

obsolete nopaline catabolic process to proline `http://purl.obolibrary.org/obo/GO_0042458`

Removed

obsolete nopaline catabolic process to proline definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of nopaline into other compounds, including proline.”
- database_cross_reference “GOC:go_curators”

Added

obsolete nopaline catabolic process to proline definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of nopaline into other compounds, including proline.”
- database_cross_reference “GOC:curators”

obsolete nucleosome modeling `http://purl.obolibrary.org/obo/GO_0016583`

Removed

obsolete nucleosome modeling definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete nucleosome modeling definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete obsolete sulfite reductase activity `http://purl.obolibrary.org/obo/GO_0016002`

Removed

obsolete obsolete sulfite reductase activity label “sulfite reductase activity”
obsolete obsolete sulfite reductase activity definition “Catalysis of the reaction: hydrogen sulfide + acceptor + 3 H2O = sulfite + reduced acceptor.”
- database_cross_reference “GOC:curators”
obsolete obsolete sulfite reductase activity SubClassOf oxidoreductase activity, acting on a sulfur group of donors

Added

obsolete obsolete sulfite reductase activity label “obsolete obsolete sulfite reductase activity”
obsolete obsolete sulfite reductase activity comment “The reason for obsoletion is that this term was an unnecessary grouping term.”
obsolete obsolete sulfite reductase activity definition “OBSOLETE. Catalysis of the reaction: hydrogen sulfide + acceptor + 3 H2O = sulfite + reduced acceptor.”
- database_cross_reference “GOC:curators”
obsolete obsolete sulfite reductase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31518”^^anyURI
obsolete obsolete sulfite reductase activity deprecated true

obsolete octopine catabolic process to proline `http://purl.obolibrary.org/obo/GO_0042459`

Removed

obsolete octopine catabolic process to proline definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of octopine into other compounds, including proline.”
- database_cross_reference “GOC:go_curators”

Added

obsolete octopine catabolic process to proline definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of octopine into other compounds, including proline.”
- database_cross_reference “GOC:curators”

obsolete oligoribonucleotidase activity `http://purl.obolibrary.org/obo/GO_0034611`

Removed

obsolete oligoribonucleotidase activity database_cross_reference “Reactome:R-HSA-9009950”
- label “PDE12 cleaves 2’-5’ oligoadenylates”
obsolete oligoribonucleotidase activity database_cross_reference “Reactome:R-HSA-9615042”
- label “Viral 2’,5’-PDE cleaves 2’-5’ oligoadenylates”

obsolete oncogenesis `http://purl.obolibrary.org/obo/GO_0007048`

Removed

obsolete oncogenesis definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete oncogenesis definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete organic anion transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0008514`

Removed

obsolete organic anion transmembrane transporter activity database_cross_reference “Reactome:R-HSA-561041”
- label “OAT1-3 transport organic anions with antiport of dicarboxylic acids”
obsolete organic anion transmembrane transporter activity database_cross_reference “Reactome:R-HSA-2142859”
- label “Growing HA is extruded from the cell by ABCC5”
obsolete organic anion transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9794830”
- label “SLC22A8 transports Cipro into renal cell”

obsolete organic cation transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015101`

Removed

obsolete organic cation transmembrane transporter activity database_cross_reference “Reactome:R-HSA-549322”
- label “OCT1 transports organic cations out of hepatic cells”
obsolete organic cation transmembrane transporter activity database_cross_reference “Reactome:R-HSA-561072”
- label “OCT3 mediates renal uptake of organic cations”
obsolete organic cation transmembrane transporter activity database_cross_reference “Reactome:R-HSA-549279”
- label “OCT2 mediates tubular uptake of organic cations in the kidney”
obsolete organic cation transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9795207”
- label “SLC22A1 transports Cipro into hepatic cell”
obsolete organic cation transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9794270”
- label “SLCO1A2 transports Cipro(1+) into the cytosol”
obsolete organic cation transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9794523”
- label “SLC22A1 transports Cipro into renal cell”
obsolete organic cation transmembrane transporter activity database_cross_reference “Reactome:R-HSA-549129”
- label “OCT1 transports organic cations into hepatic cells”
obsolete organic cation transmembrane transporter activity database_cross_reference “Reactome:R-HSA-549304”
- label “OCT3 mediates renal clearance of organic cations”
obsolete organic cation transmembrane transporter activity database_cross_reference “Reactome:R-HSA-2161500”
- label “abacavir [extracellular] => abacavir [cytosol]”
obsolete organic cation transmembrane transporter activity database_cross_reference “Reactome:R-HSA-561054”
- label “OCT2 mediates tubular secretion of organic cations in the kidney”

obsolete organic cyclic compound binding `http://purl.obolibrary.org/obo/GO_0097159`

Removed

obsolete organic cyclic compound binding database_cross_reference “Reactome:R-HSA-1497796”
- label “BH2 binding can lead to eNOS uncoupling”

obsolete organonitrogen compound metabolic process `http://purl.obolibrary.org/obo/GO_1901564`

Removed

obsolete organonitrogen compound metabolic process database_cross_reference “Reactome:R-HSA-71291”
- label “Metabolism of amino acids and derivatives”

obsolete organophosphorus resistance `http://purl.obolibrary.org/obo/GO_0008164`

Removed

obsolete organophosphorus resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete organophosphorus resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete organophosphorus susceptibility/resistance `http://purl.obolibrary.org/obo/GO_0016356`

Removed

obsolete organophosphorus susceptibility/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete organophosphorus susceptibility/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete other pathways of electron transport `http://purl.obolibrary.org/obo/GO_0006126`

Removed

obsolete other pathways of electron transport definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete other pathways of electron transport definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete oxidized low-density lipoprotein catabolic process `http://purl.obolibrary.org/obo/GO_0045194`

Removed

obsolete oxidized low-density lipoprotein catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of oxidized low-density lipoproteins.”
- database_cross_reference “GOC:go_curators”

Added

obsolete oxidized low-density lipoprotein catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of oxidized low-density lipoproteins.”
- database_cross_reference “GOC:curators”

obsolete pathogenesis `http://purl.obolibrary.org/obo/GO_0009405`

Removed

obsolete pathogenesis definition “OBSOLETE. The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.”
- database_cross_reference “GOC:go_curators”

Added

obsolete pathogenesis definition “OBSOLETE. The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.”
- database_cross_reference “GOC:curators”

obsolete peptidoglycan asparagine synthase activity `http://purl.obolibrary.org/obo/GO_0102115`

Removed

obsolete peptidoglycan asparagine synthase activity definition “Catalysis of the reaction: ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-isoglutaminyl-N-(beta-D-asparatyl)-L-lysyl-D-alanyl-D-alanine + ammonium + ATP = H+ + ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-isoglutaminyl-N-(beta-D-asparaginyl)-L-lysyl-D-alanyl-D-alanine + AMP + diphosphoric acid.”
- database_cross_reference “GOC:pz”
- database_cross_reference “EC:6.3.1.-“
obsolete peptidoglycan asparagine synthase activity database_cross_reference “MetaCyc:RXN-11338”
obsolete peptidoglycan asparagine synthase activity label “peptidoglycan asparagine synthase activity”
obsolete peptidoglycan asparagine synthase activity SubClassOf acid-ammonia (or amide) ligase activity

Added

obsolete peptidoglycan asparagine synthase activity definition “OBSOLETE. Catalysis of the reaction: ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-isoglutaminyl-N-(beta-D-asparatyl)-L-lysyl-D-alanyl-D-alanine + ammonium + ATP = H+ + ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-isoglutaminyl-N-(beta-D-asparaginyl)-L-lysyl-D-alanyl-D-alanine + AMP + diphosphoric acid.”
- database_cross_reference “GOC:pz”
obsolete peptidoglycan asparagine synthase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete peptidoglycan asparagine synthase activity deprecated true
obsolete peptidoglycan asparagine synthase activity label “obsolete peptidoglycan asparagine synthase activity”
obsolete peptidoglycan asparagine synthase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI

obsolete peptidyl-1-thioglycine biosynthetic process, carboxy-terminal `http://purl.obolibrary.org/obo/GO_0019921`

Removed

obsolete peptidyl-1-thioglycine biosynthetic process, carboxy-terminal definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of carboxy-terminal peptidyl-1-thioglycine, which has a carboxy-terminal thiocarboxy-C(=O)-SH bond.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:10660523”
- database_cross_reference “RESID:AA0265”

Added

obsolete peptidyl-1-thioglycine biosynthetic process, carboxy-terminal definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of carboxy-terminal peptidyl-1-thioglycine, which has a carboxy-terminal thiocarboxy-C(=O)-SH bond.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:10660523”
- database_cross_reference “RESID:AA0265”

obsolete peptidyl-1-thioglycine biosynthetic process, internal `http://purl.obolibrary.org/obo/GO_0019920`

Removed

obsolete peptidyl-1-thioglycine biosynthetic process, internal definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of internal peptidyl-1-thioglycine, which has an internal C=S bond, instead of an internal C=O bond, in the peptide.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:10660523”
- database_cross_reference “RESID:AA0265”

Added

obsolete peptidyl-1-thioglycine biosynthetic process, internal definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of internal peptidyl-1-thioglycine, which has an internal C=S bond, instead of an internal C=O bond, in the peptide.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:10660523”
- database_cross_reference “RESID:AA0265”

obsolete peptidyl-asparagine modification `http://purl.obolibrary.org/obo/GO_0018196`

Removed

obsolete peptidyl-asparagine modification definition “OBSOLETE. The modification of peptidyl-asparagine.”
- database_cross_reference “GOC:go_curators”

Added

obsolete peptidyl-asparagine modification definition “OBSOLETE. The modification of peptidyl-asparagine.”
- database_cross_reference “GOC:curators”

obsolete peptidyl-beta-carboxyaspartic acid biosynthetic process from peptidyl-aspartic acid `http://purl.obolibrary.org/obo/GO_0019711`

Removed

obsolete peptidyl-beta-carboxyaspartic acid biosynthetic process from peptidyl-aspartic acid definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of peptidyl-beta-carboxyaspartic acid from other compounds, including peptidyl-aspartic acid.”
- database_cross_reference “GOC:go_curators”

Added

obsolete peptidyl-beta-carboxyaspartic acid biosynthetic process from peptidyl-aspartic acid definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of peptidyl-beta-carboxyaspartic acid from other compounds, including peptidyl-aspartic acid.”
- database_cross_reference “GOC:curators”

obsolete peptidyl-diphthamide catabolic process `http://purl.obolibrary.org/obo/GO_0017184`

Removed

obsolete peptidyl-diphthamide catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthamide, a modified histidine residue.”
- database_cross_reference “GOC:go_curators”

Added

obsolete peptidyl-diphthamide catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthamide, a modified histidine residue.”
- database_cross_reference “GOC:curators”

obsolete peptidyl-diphthamide metabolic process `http://purl.obolibrary.org/obo/GO_0017182`

Removed

obsolete peptidyl-diphthamide metabolic process definition “OBSOLETE. The chemical reactions and pathways involving peptidyl-diphthamide, a modified histidine residue.”
- database_cross_reference “GOC:go_curators”

Added

obsolete peptidyl-diphthamide metabolic process definition “OBSOLETE. The chemical reactions and pathways involving peptidyl-diphthamide, a modified histidine residue.”
- database_cross_reference “GOC:curators”

obsolete peptidyl-diphthine catabolic process `http://purl.obolibrary.org/obo/GO_0017181`

Removed

obsolete peptidyl-diphthine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthine, a modified histidine residue.”
- database_cross_reference “GOC:go_curators”

Added

obsolete peptidyl-diphthine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthine, a modified histidine residue.”
- database_cross_reference “GOC:curators”

obsolete peptidyl-diphthine metabolic process `http://purl.obolibrary.org/obo/GO_0017179`

Removed

obsolete peptidyl-diphthine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving peptidyl-diphthine, a modified histidine residue.”
- database_cross_reference “GOC:go_curators”

Added

obsolete peptidyl-diphthine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving peptidyl-diphthine, a modified histidine residue.”
- database_cross_reference “GOC:curators”

obsolete peptidyl-prolyl isomerase B reaction `http://purl.obolibrary.org/obo/GO_0006460`

Removed

obsolete peptidyl-prolyl isomerase B reaction definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete peptidyl-prolyl isomerase B reaction definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete pericentric heterochromatin organization `http://purl.obolibrary.org/obo/GO_0140462`

Removed

obsolete pericentric heterochromatin organization label “pericentric heterochromatin organization”
obsolete pericentric heterochromatin organization definition “The organization of chromatin into heterochromatin at the pericentric region of a chromosome.”
- database_cross_reference “PMID:26744419”
obsolete pericentric heterochromatin organization SubClassOf heterochromatin formation

Added

obsolete pericentric heterochromatin organization comment “The reason for obsoletion is that the term is not clearly defined and usage has been inconsistent.”
obsolete pericentric heterochromatin organization deprecated true
obsolete pericentric heterochromatin organization definition “OBSOLETE. The organization of chromatin into heterochromatin at the pericentric region of a chromosome.”
- database_cross_reference “PMID:26744419”
obsolete pericentric heterochromatin organization label “obsolete pericentric heterochromatin organization”
obsolete pericentric heterochromatin organization term tracker item “https://github.com/geneontology/go-ontology/issues/31331”^^anyURI

obsolete peroxisome integral membrane receptor `http://purl.obolibrary.org/obo/GO_0005054`

Removed

obsolete peroxisome integral membrane receptor definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete peroxisome integral membrane receptor definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete peroxisome receptor `http://purl.obolibrary.org/obo/GO_0005050`

Removed

obsolete peroxisome receptor definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete peroxisome receptor definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete phenanthrol glycosyltransferase activity `http://purl.obolibrary.org/obo/GO_0019112`

Removed

obsolete phenanthrol glycosyltransferase activity label “phenanthrol glycosyltransferase activity”
obsolete phenanthrol glycosyltransferase activity definition “Catalysis of the reaction: phenanthrol + glucose = phenanthryl-beta-D-glucopyranoside + H2O.”
- database_cross_reference “GOC:ai”
obsolete phenanthrol glycosyltransferase activity SubClassOf hexosyltransferase activity

Added

obsolete phenanthrol glycosyltransferase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete phenanthrol glycosyltransferase activity deprecated true
obsolete phenanthrol glycosyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete phenanthrol glycosyltransferase activity definition “OBSOLETE. Catalysis of the reaction: phenanthrol + glucose = phenanthryl-beta-D-glucopyranoside + H2O.”
- database_cross_reference “GOC:ai”
obsolete phenanthrol glycosyltransferase activity label “obsolete phenanthrol glycosyltransferase activity”

obsolete phenol beta-glucosyltransferase activity `http://purl.obolibrary.org/obo/GO_0050171`

Removed

obsolete phenol beta-glucosyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/30193”^^anyURI
obsolete phenol beta-glucosyltransferase activity definition “Catalysis of the reaction: UDP-glucose + a phenol = UDP + an aryl beta-D-glucoside.”
- database_cross_reference “EC:2.4.1.35”
- database_cross_reference “MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN”
obsolete phenol beta-glucosyltransferase activity label “phenol beta-glucosyltransferase activity”
obsolete phenol beta-glucosyltransferase activity SubClassOf UDP-glucosyltransferase activity

Added

obsolete phenol beta-glucosyltransferase activity label “obsolete phenol beta-glucosyltransferase activity”
obsolete phenol beta-glucosyltransferase activity comment “This term was obsoleted because there is no evidence that this reaction exists.”
obsolete phenol beta-glucosyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31530”^^anyURI
obsolete phenol beta-glucosyltransferase activity deprecated true
obsolete phenol beta-glucosyltransferase activity definition “OBSOLETE. Catalysis of the reaction: UDP-glucose + a phenol = UDP + an aryl beta-D-glucoside.”
- database_cross_reference “EC:2.4.1.35”

obsolete phosphate:hydrogen symporter `http://purl.obolibrary.org/obo/GO_0005318`

Removed

obsolete phosphate:hydrogen symporter definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete phosphate:hydrogen symporter definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete phosphatidylcholine:diacylglycerol cholinephosphotransferase activity `http://purl.obolibrary.org/obo/GO_0102249`

Removed

obsolete phosphatidylcholine:diacylglycerol cholinephosphotransferase activity definition “Catalysis of the reaction: a phosphatidylcholine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + a phosphatidylcholine.”
- database_cross_reference “GOC:pz”
- database_cross_reference “MetaCyc:RXN-12386”
obsolete phosphatidylcholine:diacylglycerol cholinephosphotransferase activity database_cross_reference “MetaCyc:RXN-12386”
obsolete phosphatidylcholine:diacylglycerol cholinephosphotransferase activity label “phosphatidylcholine:diacylglycerol cholinephosphotransferase activity”
obsolete phosphatidylcholine:diacylglycerol cholinephosphotransferase activity SubClassOf phosphotransferase activity, for other substituted phosphate groups

Added

obsolete phosphatidylcholine:diacylglycerol cholinephosphotransferase activity deprecated true
obsolete phosphatidylcholine:diacylglycerol cholinephosphotransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete phosphatidylcholine:diacylglycerol cholinephosphotransferase activity definition “OBSOLETE. Catalysis of the reaction: a phosphatidylcholine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + a phosphatidylcholine.”
- database_cross_reference “GOC:pz”
obsolete phosphatidylcholine:diacylglycerol cholinephosphotransferase activity label “obsolete phosphatidylcholine:diacylglycerol cholinephosphotransferase activity”
obsolete phosphatidylcholine:diacylglycerol cholinephosphotransferase activity comment “This term was obsoleted because it represents a specific substrate.”

obsolete phosphatidylserine 1-acylhydrolase activity `http://purl.obolibrary.org/obo/GO_0052739`

Removed

obsolete phosphatidylserine 1-acylhydrolase activity database_cross_reference “Reactome:R-HSA-8869425”
- label “PLA1A hydrolyses PS to 2-acyl LPS”

obsolete phospholipid transporter activity `http://purl.obolibrary.org/obo/GO_0005548`

Removed

obsolete phospholipid transporter activity definition “Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester.”
- database_cross_reference “GOC:ai”
- database_cross_reference “ISBN:0198506732”
obsolete phospholipid transporter activity label “phospholipid transporter activity”
obsolete phospholipid transporter activity SubClassOf part of some phospholipid transport
obsolete phospholipid transporter activity SubClassOf lipid carrier activity

Added

obsolete phospholipid transporter activity consider lipid transmembrane transporter activity
obsolete phospholipid transporter activity definition “OBSOLETE. Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester.”
- database_cross_reference “GOC:ai”
- database_cross_reference “ISBN:0198506732”
obsolete phospholipid transporter activity deprecated true
obsolete phospholipid transporter activity consider phospholipid transfer activity
obsolete phospholipid transporter activity comment “This term was obsoleted because it refers to the substrate rather than to the transport mechanism as a primary classification.”
obsolete phospholipid transporter activity label “obsolete phospholipid transporter activity”
obsolete phospholipid transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/31454”^^anyURI
obsolete phospholipid transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/31460”^^anyURI

obsolete phosphoserine/phosphothreonine binding `http://purl.obolibrary.org/obo/GO_0045310`

Removed

obsolete phosphoserine/phosphothreonine binding definition “OBSOLETE. Interacting selectively with a phosphorylated serine or threonine residue within a protein.”
- database_cross_reference “GOC:go_curators”

Added

obsolete phosphoserine/phosphothreonine binding definition “OBSOLETE. Interacting selectively with a phosphorylated serine or threonine residue within a protein.”
- database_cross_reference “GOC:curators”

obsolete phototrophin mediated phototransduction `http://purl.obolibrary.org/obo/GO_0009587`

Removed

obsolete phototrophin mediated phototransduction definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete phototrophin mediated phototransduction definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete phthalate 3,4-cis-dihydrodiol dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0034912`

Removed

obsolete phthalate 3,4-cis-dihydrodiol dehydrogenase activity label “phthalate 3,4-cis-dihydrodiol dehydrogenase activity”
obsolete phthalate 3,4-cis-dihydrodiol dehydrogenase activity definition “Catalysis of the reaction: phthalate 3,4-cis-dihydrodiol + NAD+ = 3,4-dihydroxyphthalate + NADH + H+.”
- database_cross_reference “UM-BBD_reactionID:r1445”
obsolete phthalate 3,4-cis-dihydrodiol dehydrogenase activity database_cross_reference “MetaCyc:RXN5F9-56”
obsolete phthalate 3,4-cis-dihydrodiol dehydrogenase activity database_cross_reference “UM-BBD_reactionID:r1445”
obsolete phthalate 3,4-cis-dihydrodiol dehydrogenase activity SubClassOf oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

Added

obsolete phthalate 3,4-cis-dihydrodiol dehydrogenase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete phthalate 3,4-cis-dihydrodiol dehydrogenase activity definition “OBSOLETE. Catalysis of the reaction: phthalate 3,4-cis-dihydrodiol + NAD+ = 3,4-dihydroxyphthalate + NADH + H+.”
- database_cross_reference “GOC:curators”
obsolete phthalate 3,4-cis-dihydrodiol dehydrogenase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete phthalate 3,4-cis-dihydrodiol dehydrogenase activity deprecated true
obsolete phthalate 3,4-cis-dihydrodiol dehydrogenase activity label “obsolete phthalate 3,4-cis-dihydrodiol dehydrogenase activity”

obsolete phytoceramidase activity `http://purl.obolibrary.org/obo/GO_0070774`

Removed

obsolete phytoceramidase activity database_cross_reference “Reactome:R-HSA-428262”
- label “ACER3 hydrolyzes phytoceramide”

obsolete plasma membrane fusion `http://purl.obolibrary.org/obo/GO_0045026`

Removed

obsolete plasma membrane fusion label “plasma membrane fusion”
obsolete plasma membrane fusion definition “The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell.”
- database_cross_reference “GOC:elh”
- database_cross_reference “GOC:mtg_muscle”
obsolete plasma membrane fusion SubClassOf plasma membrane organization
obsolete plasma membrane fusion SubClassOf membrane fusion

Added

obsolete plasma membrane fusion term replaced by cell-cell fusion
obsolete plasma membrane fusion definition “OBSOLETE. The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell.”
- database_cross_reference “GOC:elh”
- database_cross_reference “GOC:mtg_muscle”
obsolete plasma membrane fusion deprecated true
obsolete plasma membrane fusion label “obsolete plasma membrane fusion”
obsolete plasma membrane fusion comment “This term is represented by another term.”
obsolete plasma membrane fusion term tracker item “https://github.com/geneontology/go-ontology/issues/31270”^^anyURI

obsolete plasma membrane fusion involved in cytogamy `http://purl.obolibrary.org/obo/GO_0032220`

Removed

obsolete plasma membrane fusion involved in cytogamy definition “The joining of two or more lipid bilayer membranes that surround cells, that contributes to cytogamy.”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:29134248”
obsolete plasma membrane fusion involved in cytogamy label “plasma membrane fusion involved in cytogamy”
obsolete plasma membrane fusion involved in cytogamy EquivalentTo obsolete plasma membrane fusion and (part of some cytogamy)
obsolete plasma membrane fusion involved in cytogamy SubClassOf obsolete plasma membrane fusion
obsolete plasma membrane fusion involved in cytogamy SubClassOf part of some cytogamy

Added

obsolete plasma membrane fusion involved in cytogamy label “obsolete plasma membrane fusion involved in cytogamy”
obsolete plasma membrane fusion involved in cytogamy consider cell-cell fusion
obsolete plasma membrane fusion involved in cytogamy deprecated true
obsolete plasma membrane fusion involved in cytogamy definition “OBSOLETE. The joining of two or more lipid bilayer membranes that surround cells, that contributes to cytogamy.”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:29134248”
obsolete plasma membrane fusion involved in cytogamy comment “precomposed term, represents a GO-CAM model.”
obsolete plasma membrane fusion involved in cytogamy term tracker item “https://github.com/geneontology/go-ontology/issues/31270”^^anyURI

obsolete poly-A binding `http://purl.obolibrary.org/obo/GO_0006380`

Removed

obsolete poly-A binding definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete poly-A binding definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete polyubiquitin `http://purl.obolibrary.org/obo/GO_0005552`

Removed

obsolete polyubiquitin definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete polyubiquitin definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete positive regulation of CD4 production `http://purl.obolibrary.org/obo/GO_0045224`

Removed

obsolete positive regulation of CD4 production definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of CD4 production definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of FasL production `http://purl.obolibrary.org/obo/GO_0045220`

Removed

obsolete positive regulation of FasL production definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of FasL production definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of Golgi lumen acidification `http://purl.obolibrary.org/obo/GO_1905528`

Removed

obsolete positive regulation of Golgi lumen acidification definition “Any process that activates or increases the frequency, rate or extent of Golgi lumen acidification.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:23447592”
- database_cross_reference “GO_REF:0000058”
obsolete positive regulation of Golgi lumen acidification label “positive regulation of Golgi lumen acidification”
obsolete positive regulation of Golgi lumen acidification EquivalentTo biological regulation and (positively regulates some Golgi lumen acidification)
obsolete positive regulation of Golgi lumen acidification SubClassOf positively regulates some Golgi lumen acidification
obsolete positive regulation of Golgi lumen acidification SubClassOf obsolete regulation of Golgi lumen acidification
obsolete positive regulation of Golgi lumen acidification SubClassOf obsolete positive regulation of cellular pH reduction

Added

obsolete positive regulation of Golgi lumen acidification label “obsolete positive regulation of Golgi lumen acidification”
obsolete positive regulation of Golgi lumen acidification deprecated true
obsolete positive regulation of Golgi lumen acidification definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of Golgi lumen acidification.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:23447592”
- database_cross_reference “GO_REF:0000058”
obsolete positive regulation of Golgi lumen acidification term tracker item “https://github.com/geneontology/go-ontology/issues/29164”^^anyURI
obsolete positive regulation of Golgi lumen acidification term replaced by Golgi lumen acidification
obsolete positive regulation of Golgi lumen acidification comment “This term was added in error. Regulating regulation is redundant.”

obsolete positive regulation of L-tryptophan metabolic process `http://purl.obolibrary.org/obo/GO_0090358`

Removed

obsolete positive regulation of L-tryptophan metabolic process label “positive regulation of L-tryptophan metabolic process”
obsolete positive regulation of L-tryptophan metabolic process definition “Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.”
- database_cross_reference “GOC:tb”
obsolete positive regulation of L-tryptophan metabolic process EquivalentTo biological regulation and (positively regulates some L-tryptophan metabolic process)
obsolete positive regulation of L-tryptophan metabolic process SubClassOf positive regulation of small molecule metabolic process
obsolete positive regulation of L-tryptophan metabolic process SubClassOf positive regulation of amino acid metabolic process
obsolete positive regulation of L-tryptophan metabolic process SubClassOf positively regulates some L-tryptophan metabolic process
obsolete positive regulation of L-tryptophan metabolic process SubClassOf obsolete regulation of L-tryptophan metabolic process

Added

obsolete positive regulation of L-tryptophan metabolic process deprecated true
obsolete positive regulation of L-tryptophan metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31171”^^anyURI
obsolete positive regulation of L-tryptophan metabolic process definition “OBSOLETE. Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.”
- database_cross_reference “GOC:tb”
obsolete positive regulation of L-tryptophan metabolic process label “obsolete positive regulation of L-tryptophan metabolic process”
obsolete positive regulation of L-tryptophan metabolic process comment “The reason for obsoletion is that this term was an unnecessary grouping terms and only ‘biosynthetic’ or ‘catabolic’ process should be used.”

obsolete positive regulation of S phase of mitotic cell cycle `http://purl.obolibrary.org/obo/GO_0045750`

Removed

obsolete positive regulation of S phase of mitotic cell cycle definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of S phase of mitotic cell cycle activity.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of S phase of mitotic cell cycle definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of S phase of mitotic cell cycle activity.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of TRAIL receptor 1 biosynthetic process `http://purl.obolibrary.org/obo/GO_0045566`

Removed

obsolete positive regulation of TRAIL receptor 1 biosynthetic process definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of TRAIL receptor 1 biosynthetic process definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of TRAIL receptor 2 biosynthetic process `http://purl.obolibrary.org/obo/GO_0045568`

Removed

obsolete positive regulation of TRAIL receptor 2 biosynthetic process definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of TRAIL receptor 2 biosynthetic process definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of TRAIL receptor biosynthetic process `http://purl.obolibrary.org/obo/GO_0045564`

Removed

obsolete positive regulation of TRAIL receptor biosynthetic process definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of TRAIL receptor biosynthetic process definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of actin polymerization and/or depolymerization `http://purl.obolibrary.org/obo/GO_0045758`

Removed

obsolete positive regulation of actin polymerization and/or depolymerization definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of actin polymerization and/or depolymerization.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of actin polymerization and/or depolymerization definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of actin polymerization and/or depolymerization.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of anti-apoptosis `http://purl.obolibrary.org/obo/GO_0045768`

Removed

obsolete positive regulation of anti-apoptosis definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of anti-apoptosis.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_apoptosis”

Added

obsolete positive regulation of anti-apoptosis definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of anti-apoptosis.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_apoptosis”

obsolete positive regulation of calcium in ER `http://purl.obolibrary.org/obo/GO_0045784`

Removed

obsolete positive regulation of calcium in ER definition “OBSOLETE. Any process that increases the concentration of calcium in the ER.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of calcium in ER definition “OBSOLETE. Any process that increases the concentration of calcium in the ER.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of catecholamine metabolic process `http://purl.obolibrary.org/obo/GO_0045915`

Removed

obsolete positive regulation of catecholamine metabolic process definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of catecholamine metabolic process definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of cellular metabolic process `http://purl.obolibrary.org/obo/GO_0031325`

Removed

obsolete positive regulation of cellular metabolic process database_cross_reference “Reactome:R-HSA-163765”
- label “ChREBP activates metabolic gene expression”

obsolete positive regulation of cellular pH reduction `http://purl.obolibrary.org/obo/GO_0032849`

Removed

obsolete positive regulation of cellular pH reduction has_exact_synonym “positive regulation of cell pH reduction”
obsolete positive regulation of cellular pH reduction definition “Any process that activates or increases the frequency, rate, or extent of a process that reduces the internal pH of a cell.”
- database_cross_reference “GOC:mah”
obsolete positive regulation of cellular pH reduction label “positive regulation of cellular pH reduction”
obsolete positive regulation of cellular pH reduction has_exact_synonym “upregulation of cellular pH reduction”
obsolete positive regulation of cellular pH reduction has_exact_synonym “positive regulation of reduction of cellular pH”
obsolete positive regulation of cellular pH reduction has_exact_synonym “positive regulation of intracellular pH reduction”
obsolete positive regulation of cellular pH reduction has_narrow_synonym “activation of cellular pH reduction”
obsolete positive regulation of cellular pH reduction has_exact_synonym “positive regulation of reduction of pH in cell”
obsolete positive regulation of cellular pH reduction has_related_synonym “positive regulation of intracellular acidification”
obsolete positive regulation of cellular pH reduction has_narrow_synonym “stimulation of cellular pH reduction”
obsolete positive regulation of cellular pH reduction has_exact_synonym “positive regulation of cellular acidification”
obsolete positive regulation of cellular pH reduction has_exact_synonym “up-regulation of cellular pH reduction”
obsolete positive regulation of cellular pH reduction has_exact_synonym “up regulation of cellular pH reduction”
obsolete positive regulation of cellular pH reduction EquivalentTo biological regulation and (positively regulates some intracellular pH reduction)
obsolete positive regulation of cellular pH reduction SubClassOf obsolete regulation of cellular pH reduction
obsolete positive regulation of cellular pH reduction SubClassOf positively regulates some intracellular pH reduction
obsolete positive regulation of cellular pH reduction SubClassOf positive regulation of biological process
obsolete positive regulation of cellular pH reduction SubClassOf intracellular pH reduction

Added

obsolete positive regulation of cellular pH reduction comment “This term was obsoleted because it represents ‘regulation of regulation’, which is redundant with direct pH regulation terms.”
obsolete positive regulation of cellular pH reduction deprecated true
obsolete positive regulation of cellular pH reduction definition “OBSOLETE. Any process that activates or increases the frequency, rate, or extent of a process that reduces the internal pH of a cell.”
- database_cross_reference “GOC:mah”
obsolete positive regulation of cellular pH reduction term tracker item “https://github.com/geneontology/go-ontology/issues/29164”^^anyURI
obsolete positive regulation of cellular pH reduction label “obsolete positive regulation of cellular pH reduction”
obsolete positive regulation of cellular pH reduction term replaced by intracellular pH reduction

obsolete positive regulation of cytoskeleton `http://purl.obolibrary.org/obo/GO_0045803`

Removed

obsolete positive regulation of cytoskeleton definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of cytoskeleton definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of early endosome to recycling endosome transport `http://purl.obolibrary.org/obo/GO_1902955`

Removed

obsolete positive regulation of early endosome to recycling endosome transport label “positive regulation of early endosome to recycling endosome transport”
obsolete positive regulation of early endosome to recycling endosome transport has_narrow_synonym “activation of early endosome to recycling endosome transport”
- database_cross_reference “GOC:TermGenie”
obsolete positive regulation of early endosome to recycling endosome transport has_exact_synonym “up-regulation of early endosome to recycling endosome transport”
- database_cross_reference “GOC:TermGenie”
obsolete positive regulation of early endosome to recycling endosome transport has_exact_synonym “up regulation of early endosome to recycling endosome transport”
- database_cross_reference “GOC:TermGenie”
obsolete positive regulation of early endosome to recycling endosome transport has_exact_synonym “upregulation of early endosome to recycling endosome transport”
- database_cross_reference “GOC:TermGenie”
obsolete positive regulation of early endosome to recycling endosome transport definition “Any process that activates or increases the frequency, rate or extent of early endosome to recycling endosome transport.”
- database_cross_reference “PMID:22621900”
- database_cross_reference “GOC:sjp”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “GO_REF:0000058”
obsolete positive regulation of early endosome to recycling endosome transport EquivalentTo biological regulation and (positively regulates some obsolete early endosome to recycling endosome transport)
obsolete positive regulation of early endosome to recycling endosome transport SubClassOf positively regulates some obsolete early endosome to recycling endosome transport
obsolete positive regulation of early endosome to recycling endosome transport SubClassOf obsolete regulation of early endosome to recycling endosome transport
obsolete positive regulation of early endosome to recycling endosome transport SubClassOf positive regulation of intracellular transport

Added

obsolete positive regulation of early endosome to recycling endosome transport definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of early endosome to recycling endosome transport.”
- database_cross_reference “PMID:22621900”
- database_cross_reference “GOC:sjp”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “GO_REF:0000058”
obsolete positive regulation of early endosome to recycling endosome transport label “obsolete positive regulation of early endosome to recycling endosome transport”
obsolete positive regulation of early endosome to recycling endosome transport comment “This term is described by another GO term.”
obsolete positive regulation of early endosome to recycling endosome transport term replaced by positive regulation of endocytic recycling
obsolete positive regulation of early endosome to recycling endosome transport deprecated true
obsolete positive regulation of early endosome to recycling endosome transport term tracker item “https://github.com/geneontology/go-ontology/issues/31240”^^anyURI

obsolete positive regulation of ecdysteroid metabolic process `http://purl.obolibrary.org/obo/GO_0045966`

Removed

obsolete positive regulation of ecdysteroid metabolic process definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of ecdysteroid metabolic process definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of epidermal growth factor-activated receptor activity `http://purl.obolibrary.org/obo/GO_0045741`

Removed

obsolete positive regulation of epidermal growth factor-activated receptor activity definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of epidermal growth factor-activated receptor activity definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of initiation of acetate catabolic process by acetate `http://purl.obolibrary.org/obo/GO_0045756`

Removed

obsolete positive regulation of initiation of acetate catabolic process by acetate definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of initiation of acetate catabolic process by acetate definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter `http://purl.obolibrary.org/obo/GO_1900375`

Removed

obsolete positive regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter definition “OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of inositol biosynthetic process.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:2004420”

Added

obsolete positive regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter definition “OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of inositol biosynthetic process.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:2004420”

obsolete positive regulation of intermediate filament polymerization and/or depolymerization `http://purl.obolibrary.org/obo/GO_0045826`

Removed

obsolete positive regulation of intermediate filament polymerization and/or depolymerization definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization and/or depolymerization.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of intermediate filament polymerization and/or depolymerization definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization and/or depolymerization.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of isoprenoid metabolic process `http://purl.obolibrary.org/obo/GO_0045828`

Removed

obsolete positive regulation of isoprenoid metabolic process definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of isoprenoid metabolic process definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of juvenile hormone metabolic process `http://purl.obolibrary.org/obo/GO_0045929`

Removed

obsolete positive regulation of juvenile hormone metabolic process definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of juvenile hormone metabolic process definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of light-activated channel activity `http://purl.obolibrary.org/obo/GO_0045832`

Removed

obsolete positive regulation of light-activated channel activity definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of light-activated channel activity.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of light-activated channel activity definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of light-activated channel activity.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of low-density lipoprotein particle receptor biosynthetic process `http://purl.obolibrary.org/obo/GO_0045716`

Removed

obsolete positive regulation of low-density lipoprotein particle receptor biosynthetic process definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of low-density lipoprotein particle receptor biosynthetic process definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of mating type switching by regulation of transcription from RNA polymerase II promoter `http://purl.obolibrary.org/obo/GO_1900374`

Removed

obsolete positive regulation of mating type switching by regulation of transcription from RNA polymerase II promoter definition “OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in positive regulation of mating type switching.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:8804308”

Added

obsolete positive regulation of mating type switching by regulation of transcription from RNA polymerase II promoter definition “OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in positive regulation of mating type switching.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:8804308”

obsolete positive regulation of molecular function, epigenetic `http://purl.obolibrary.org/obo/GO_0045858`

Removed

obsolete positive regulation of molecular function, epigenetic definition “OBSOLETE. Any heritable epigenetic process that increases the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich (‘prion’) domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

obsolete positive regulation of molecular function, epigenetic definition “OBSOLETE. Any heritable epigenetic process that increases the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich (‘prion’) domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

obsolete positive regulation of myosin light chain kinase activity `http://purl.obolibrary.org/obo/GO_0035505`

Removed

obsolete positive regulation of myosin light chain kinase activity definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of myosin light chain kinase activity.”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of myosin light chain kinase activity definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of myosin light chain kinase activity.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:bf”

obsolete positive regulation of myosin-light-chain-phosphatase activity `http://purl.obolibrary.org/obo/GO_0035508`

Removed

obsolete positive regulation of myosin-light-chain-phosphatase activity definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of myosin-light-chain-phosphatase activity.”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of myosin-light-chain-phosphatase activity definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of myosin-light-chain-phosphatase activity.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:bf”

obsolete positive regulation of nitric oxide mediated signal transduction `http://purl.obolibrary.org/obo/GO_0010750`

Removed

obsolete positive regulation of nitric oxide mediated signal transduction has_exact_synonym “positive regulation of nitric oxide-mediated signal transduction”
obsolete positive regulation of nitric oxide mediated signal transduction label “positive regulation of nitric oxide mediated signal transduction”
obsolete positive regulation of nitric oxide mediated signal transduction definition “Any process that increases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO).”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:BHF”
obsolete positive regulation of nitric oxide mediated signal transduction EquivalentTo biological regulation and (positively regulates some obsolete nitric oxide mediated signal transduction)
obsolete positive regulation of nitric oxide mediated signal transduction SubClassOf positively regulates some obsolete nitric oxide mediated signal transduction
obsolete positive regulation of nitric oxide mediated signal transduction SubClassOf positive regulation of intracellular signal transduction
obsolete positive regulation of nitric oxide mediated signal transduction SubClassOf obsolete regulation of nitric oxide mediated signal transduction

Added

obsolete positive regulation of nitric oxide mediated signal transduction comment “The reason for obsoletion is that this term has been inconsistently used and NO signaling proceeds via cGMP, so the more specific replacement term is preferred.”
obsolete positive regulation of nitric oxide mediated signal transduction definition “OBSOLETE. Any process that increases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO).”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:BHF”
obsolete positive regulation of nitric oxide mediated signal transduction label “obsolete positive regulation of nitric oxide mediated signal transduction”
obsolete positive regulation of nitric oxide mediated signal transduction term replaced by positive regulation of nitric oxide-cGMP mediated signal transduction
obsolete positive regulation of nitric oxide mediated signal transduction term tracker item “https://github.com/geneontology/go-ontology/issues/26613”^^anyURI
obsolete positive regulation of nitric oxide mediated signal transduction deprecated true

obsolete positive regulation of nucleobase-containing compound metabolic process `http://purl.obolibrary.org/obo/GO_0045935`

Removed

obsolete positive regulation of nucleobase-containing compound metabolic process definition “OBSOLETE. Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of nucleobase-containing compound metabolic process definition “OBSOLETE. Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of pteridine metabolic process `http://purl.obolibrary.org/obo/GO_0045864`

Removed

obsolete positive regulation of pteridine metabolic process definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pteridine.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of pteridine metabolic process definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pteridine.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of recombination within rDNA repeats `http://purl.obolibrary.org/obo/GO_0045866`

Removed

obsolete positive regulation of recombination within rDNA repeats definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

obsolete positive regulation of recombination within rDNA repeats definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

obsolete positive regulation of rhodopsin gene expression `http://purl.obolibrary.org/obo/GO_0045872`

Removed

obsolete positive regulation of rhodopsin gene expression definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of rhodopsin gene expression.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

obsolete positive regulation of rhodopsin gene expression definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of rhodopsin gene expression.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

obsolete positive regulation of survival gene product expression `http://purl.obolibrary.org/obo/GO_0045885`

Removed

obsolete positive regulation of survival gene product expression definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:mtg_apoptosis”

Added

obsolete positive regulation of survival gene product expression definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:mtg_apoptosis”

obsolete positive regulation of tau-protein kinase activity `http://purl.obolibrary.org/obo/GO_1902949`

Removed

obsolete positive regulation of tau-protein kinase activity database_cross_reference “Reactome:R-HSA-9032845”
- label “Activated NTRK2 signals through CDK5”

obsolete positive regulation of transcription by pheromones `http://purl.obolibrary.org/obo/GO_0009371`

Removed

obsolete positive regulation of transcription by pheromones definition “OBSOLETE. Any process involving pheromones that activates or increases the rate of transcription.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of transcription by pheromones definition “OBSOLETE. Any process involving pheromones that activates or increases the rate of transcription.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of transcription during mitotic cell cycle `http://purl.obolibrary.org/obo/GO_0045897`

Removed

obsolete positive regulation of transcription during mitotic cell cycle definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription that occurs during the mitotic cell cycle.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of transcription during mitotic cell cycle definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription that occurs during the mitotic cell cycle.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of transcription from RNA polymerase I promoter during mitotic cell cycle `http://purl.obolibrary.org/obo/GO_0046018`

Removed

obsolete positive regulation of transcription from RNA polymerase I promoter during mitotic cell cycle definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase I promoter that occurs during the mitotic cell cycle.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of transcription from RNA polymerase I promoter during mitotic cell cycle definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase I promoter that occurs during the mitotic cell cycle.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of transcription from RNA polymerase II promoter by pheromones `http://purl.obolibrary.org/obo/GO_0007329`

Removed

obsolete positive regulation of transcription from RNA polymerase II promoter by pheromones definition “OBSOLETE. Any process involving pheromones that activates or increases the rate of transcription from an RNA polymerase II promoter.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of transcription from RNA polymerase II promoter by pheromones definition “OBSOLETE. Any process involving pheromones that activates or increases the rate of transcription from an RNA polymerase II promoter.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of transcription from RNA polymerase II promoter during mitotic cell cycle `http://purl.obolibrary.org/obo/GO_0046022`

Removed

obsolete positive regulation of transcription from RNA polymerase II promoter during mitotic cell cycle definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that occurs during the mitotic cell cycle.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of transcription from RNA polymerase II promoter during mitotic cell cycle definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that occurs during the mitotic cell cycle.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of transcription from RNA polymerase II promoter in response to acidic pH `http://purl.obolibrary.org/obo/GO_0061402`

Removed

obsolete positive regulation of transcription from RNA polymerase II promoter in response to acidic pH definition “OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a pH stimulus with pH < 7.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of transcription from RNA polymerase II promoter in response to acidic pH definition “OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a pH stimulus with pH < 7.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”

obsolete positive regulation of transcription from RNA polymerase III promoter during mitotic cell cycle `http://purl.obolibrary.org/obo/GO_0046024`

Removed

obsolete positive regulation of transcription from RNA polymerase III promoter during mitotic cell cycle definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase III that occurs during the mitotic cell cycle.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of transcription from RNA polymerase III promoter during mitotic cell cycle definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase III that occurs during the mitotic cell cycle.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of transcription of homeotic gene (Polycomb group) `http://purl.obolibrary.org/obo/GO_0045889`

Removed

obsolete positive regulation of transcription of homeotic gene (Polycomb group) definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of homeotic genes of the Polycomb group.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of transcription of homeotic gene (Polycomb group) definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of homeotic genes of the Polycomb group.”
- database_cross_reference “GOC:curators”

obsolete positive regulation of transcription of homeotic gene (trithorax group) `http://purl.obolibrary.org/obo/GO_0006339`

Removed

obsolete positive regulation of transcription of homeotic gene (trithorax group) definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of homeotic genes of the trithorax group.”
- database_cross_reference “GOC:go_curators”

Added

obsolete positive regulation of transcription of homeotic gene (trithorax group) definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of homeotic genes of the trithorax group.”
- database_cross_reference “GOC:curators”

obsolete proline catabolic process to 2-oxoglutarate `http://purl.obolibrary.org/obo/GO_0019495`

Removed

obsolete proline catabolic process to 2-oxoglutarate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including 2-oxoglutarate.”
- database_cross_reference “GOC:go_curators”

Added

obsolete proline catabolic process to 2-oxoglutarate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including 2-oxoglutarate.”
- database_cross_reference “GOC:curators”

obsolete propionate catabolic process, 2-methylcitrate cycle `http://purl.obolibrary.org/obo/GO_0019629`

Removed

obsolete propionate catabolic process, 2-methylcitrate cycle definition “The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle.”
- database_cross_reference “GOC:go_curators”
obsolete propionate catabolic process, 2-methylcitrate cycle label “propionate catabolic process, 2-methylcitrate cycle”
obsolete propionate catabolic process, 2-methylcitrate cycle SubClassOf propionate catabolic process

Added

obsolete propionate catabolic process, 2-methylcitrate cycle label “obsolete propionate catabolic process, 2-methylcitrate cycle”
obsolete propionate catabolic process, 2-methylcitrate cycle comment “The reason for obsoletion is that the meaning of the term is too narrow.”
obsolete propionate catabolic process, 2-methylcitrate cycle term tracker item “https://github.com/geneontology/go-ontology/issues/31668”^^anyURI
obsolete propionate catabolic process, 2-methylcitrate cycle deprecated true
obsolete propionate catabolic process, 2-methylcitrate cycle term replaced by propionate catabolic process
obsolete propionate catabolic process, 2-methylcitrate cycle definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle.”
- database_cross_reference “GOC:curators”

obsolete propionate metabolic process, methylcitrate cycle `http://purl.obolibrary.org/obo/GO_0019679`

Removed

obsolete propionate metabolic process, methylcitrate cycle definition “The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle.”
- database_cross_reference “GOC:go_curators”
obsolete propionate metabolic process, methylcitrate cycle database_cross_reference “MetaCyc:PWY0-42”
obsolete propionate metabolic process, methylcitrate cycle label “propionate metabolic process, methylcitrate cycle”
obsolete propionate metabolic process, methylcitrate cycle SubClassOf propionate metabolic process

Added

obsolete propionate metabolic process, methylcitrate cycle term tracker item “https://github.com/geneontology/go-ontology/issues/31668”^^anyURI
obsolete propionate metabolic process, methylcitrate cycle label “obsolete propionate metabolic process, methylcitrate cycle”
obsolete propionate metabolic process, methylcitrate cycle deprecated true
obsolete propionate metabolic process, methylcitrate cycle comment “The reason for obsoletion is that the meaning of the term is too narrow.”
obsolete propionate metabolic process, methylcitrate cycle definition “OBSOLETE. The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle.”
- database_cross_reference “GOC:curators”
obsolete propionate metabolic process, methylcitrate cycle term replaced by propionate catabolic process

obsolete propionate metabolic process, methylmalonyl pathway `http://purl.obolibrary.org/obo/GO_0019678`

Removed

obsolete propionate metabolic process, methylmalonyl pathway database_cross_reference “MetaCyc:PROPIONMET-PWY”
obsolete propionate metabolic process, methylmalonyl pathway label “propionate metabolic process, methylmalonyl pathway”
obsolete propionate metabolic process, methylmalonyl pathway definition “The chemical reactions and pathways involving propionate that occur in the methylmalonyl pathway.”
- database_cross_reference “GOC:go_curators”
obsolete propionate metabolic process, methylmalonyl pathway SubClassOf propionate metabolic process

Added

obsolete propionate metabolic process, methylmalonyl pathway label “obsolete propionate metabolic process, methylmalonyl pathway”
obsolete propionate metabolic process, methylmalonyl pathway has_exact_synonym “methylmalonyl pathway”
obsolete propionate metabolic process, methylmalonyl pathway term tracker item “https://github.com/geneontology/go-ontology/issues/31668”^^anyURI
obsolete propionate metabolic process, methylmalonyl pathway deprecated true
obsolete propionate metabolic process, methylmalonyl pathway has_exact_synonym “propanoyl CoA degradation”
obsolete propionate metabolic process, methylmalonyl pathway term replaced by propionyl-CoA catabolic process
obsolete propionate metabolic process, methylmalonyl pathway comment “The reason for obsoletion is that the meaning of the term is too narrow.”
obsolete propionate metabolic process, methylmalonyl pathway definition “OBSOLETE. The chemical reactions and pathways involving propionate that occur in the methylmalonyl pathway.”
- database_cross_reference “GOC:curators”

obsolete proteasome endopeptidase core `http://purl.obolibrary.org/obo/GO_0016026`

Removed

obsolete proteasome endopeptidase core definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete proteasome endopeptidase core definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete proteasome endopeptidase regulator `http://purl.obolibrary.org/obo/GO_0016025`

Removed

obsolete proteasome endopeptidase regulator definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete proteasome endopeptidase regulator definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete protein C-terminal methylesterase activity `http://purl.obolibrary.org/obo/GO_0051722`

Removed

obsolete protein C-terminal methylesterase activity database_cross_reference “Reactome:R-HSA-8856951”
- label “PP2A demethylation by PPME1”

obsolete protein N-linked glycosylation via asparagine `http://purl.obolibrary.org/obo/GO_0018279`

Removed

obsolete protein N-linked glycosylation via asparagine database_cross_reference “Reactome:R-HSA-446203”
- label “Asparagine N-linked glycosylation”
obsolete protein N-linked glycosylation via asparagine database_cross_reference “Reactome:R-HSA-480985”
- label “Synthesis of dolichyl-phosphate-glucose”
obsolete protein N-linked glycosylation via asparagine database_cross_reference “Reactome:R-HSA-162699”
- label “Synthesis of dolichyl-phosphate mannose”

obsolete protein histidyl modification to diphthine `http://purl.obolibrary.org/obo/GO_0017180`

Removed

obsolete protein histidyl modification to diphthine definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of peptidyl-diphthine from other compounds, including peptidyl-histidine.”
- database_cross_reference “GOC:go_curators”

Added

obsolete protein histidyl modification to diphthine definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of peptidyl-diphthine from other compounds, including peptidyl-histidine.”
- database_cross_reference “GOC:curators”

obsolete protein kinase A signaling `http://purl.obolibrary.org/obo/GO_0010737`

Removed

obsolete protein kinase A signaling database_cross_reference “Reactome:R-HSA-163358”
- label “PKA-mediated phosphorylation of key metabolic factors”

obsolete protein localization to mating-type region heterochromatin `http://purl.obolibrary.org/obo/GO_1903212`

Removed

obsolete protein localization to mating-type region heterochromatin definition “A process in which a protein is transported to, or maintained in, a location within a mating-type region heterochromatin.”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:18761674”
- database_cross_reference “GO_REF:0000087”
obsolete protein localization to mating-type region heterochromatin label “protein localization to mating-type region heterochromatin”
obsolete protein localization to mating-type region heterochromatin SubClassOf protein localization to heterochromatin

Added

obsolete protein localization to mating-type region heterochromatin definition “OBSOLETE. A process in which a protein is transported to, or maintained in, a location within a mating-type region heterochromatin.”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:18761674”
- database_cross_reference “GO_REF:0000087”
obsolete protein localization to mating-type region heterochromatin label “obsolete protein localization to mating-type region heterochromatin”
obsolete protein localization to mating-type region heterochromatin term tracker item “https://github.com/geneontology/go-ontology/issues/31529”^^anyURI
obsolete protein localization to mating-type region heterochromatin comment “This term was obsoleted because it represents a precomposed term.”
obsolete protein localization to mating-type region heterochromatin deprecated true
obsolete protein localization to mating-type region heterochromatin term replaced by protein localization to chromatin

obsolete protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity `http://purl.obolibrary.org/obo/GO_0090590`

Removed

obsolete protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity definition “Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + D-glucosamine(out) = protein histidine + glucosamine-6-phosphate(in).”
- database_cross_reference “PMID:8246840”
obsolete protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity label “protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity”
obsolete protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity SubClassOf protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity

Added

obsolete protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity label “obsolete protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity”
obsolete protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity definition “OBSOLETE. Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + D-glucosamine(out) = protein histidine + glucosamine-6-phosphate(in).”
- database_cross_reference “PMID:8246840”
obsolete protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity deprecated true
obsolete protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity term replaced by protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity
obsolete protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity comment “This term was obsoleted because it represents a specific substrate of protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity ; GO:0022870 (see PMID:8246840).”
obsolete protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/31586”^^anyURI

obsolete protein-N(pi)-phosphohistidine–N-acetyl-D-glucosamine phosphotransferase activity `http://purl.obolibrary.org/obo/GO_0103111`

Removed

obsolete protein-N(pi)-phosphohistidine–N-acetyl-D-glucosamine phosphotransferase activity definition “Catalysis of the reaction: N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) = L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in).”
- database_cross_reference “RHEA:49240”
obsolete protein-N(pi)-phosphohistidine–N-acetyl-D-glucosamine phosphotransferase activity exactMatch 2.7.1.193
obsolete protein-N(pi)-phosphohistidine–N-acetyl-D-glucosamine phosphotransferase activity label “protein-N(pi)-phosphohistidine–N-acetyl-D-glucosamine phosphotransferase activity”
obsolete protein-N(pi)-phosphohistidine–N-acetyl-D-glucosamine phosphotransferase activity exactMatch 49240
obsolete protein-N(pi)-phosphohistidine–N-acetyl-D-glucosamine phosphotransferase activity database_cross_reference “EC:2.7.1.193”
obsolete protein-N(pi)-phosphohistidine–N-acetyl-D-glucosamine phosphotransferase activity database_cross_reference “RHEA:49240”
obsolete protein-N(pi)-phosphohistidine–N-acetyl-D-glucosamine phosphotransferase activity SubClassOf phosphotransferase activity, alcohol group as acceptor

Added

obsolete protein-N(pi)-phosphohistidine–N-acetyl-D-glucosamine phosphotransferase activity deprecated true
obsolete protein-N(pi)-phosphohistidine–N-acetyl-D-glucosamine phosphotransferase activity label “obsolete protein-N(pi)-phosphohistidine–N-acetyl-D-glucosamine phosphotransferase activity”
obsolete protein-N(pi)-phosphohistidine–N-acetyl-D-glucosamine phosphotransferase activity comment “This term was obsoleted because it represents the same reaction as [protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity ; GO:0022880.”
obsolete protein-N(pi)-phosphohistidine–N-acetyl-D-glucosamine phosphotransferase activity definition “OBSOLETE. Catalysis of the reaction: N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) = L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in).”
- database_cross_reference “RHEA:49240”
obsolete protein-N(pi)-phosphohistidine–N-acetyl-D-glucosamine phosphotransferase activity term replaced by protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity
obsolete protein-N(pi)-phosphohistidine–N-acetyl-D-glucosamine phosphotransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31586”^^anyURI

obsolete protein-tyrosine iodotransferase activity `http://purl.obolibrary.org/obo/GO_0160320`

Removed

obsolete protein-tyrosine iodotransferase activity database_cross_reference “RHEA:48956”
obsolete protein-tyrosine iodotransferase activity label “protein-tyrosine iodotransferase activity”
obsolete protein-tyrosine iodotransferase activity narrowMatch 48956
obsolete protein-tyrosine iodotransferase activity narrowMatch 48960
obsolete protein-tyrosine iodotransferase activity definition “Catalysis of the reaction: [thyroglobulin]-L-tyrosine + iodide + H2O2 + H+ = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O and [thyroglobulin]-3-iodo-L-tyrosine + iodide + H2O2 + H+ = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O.”
- database_cross_reference “PMID:8651700”
- database_cross_reference “PMID:36537574”
obsolete protein-tyrosine iodotransferase activity database_cross_reference “RHEA:48960”
obsolete protein-tyrosine iodotransferase activity creation date “2026-01-21T23:56:40Z”
obsolete protein-tyrosine iodotransferase activity created by “rynl”
obsolete protein-tyrosine iodotransferase activity SubClassOf haloperoxidase activity

Added

obsolete protein-tyrosine iodotransferase activity comment “The reason for obsoletion is that the reactions covered by this term (RHEA:48956 and RHEA:48960) are now subsumed by the updated GO:0004447 (iodide peroxidase activity), which covers all 5 thyroid peroxidase reactions.”
obsolete protein-tyrosine iodotransferase activity deprecated true
obsolete protein-tyrosine iodotransferase activity definition “OBSOLETE. Catalysis of the reaction: [thyroglobulin]-L-tyrosine + iodide + H2O2 + H+ = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O and [thyroglobulin]-3-iodo-L-tyrosine + iodide + H2O2 + H+ = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O.”
- database_cross_reference “PMID:8651700”
- database_cross_reference “PMID:36537574”
obsolete protein-tyrosine iodotransferase activity term replaced by iodide peroxidase activity
obsolete protein-tyrosine iodotransferase activity label “obsolete protein-tyrosine iodotransferase activity”

obsolete proteoglycan `http://purl.obolibrary.org/obo/GO_0005203`

Removed

obsolete proteoglycan definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete proteoglycan definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete proteoglycan integral to plasma membrane `http://purl.obolibrary.org/obo/GO_0005888`

Removed

obsolete proteoglycan integral to plasma membrane definition “OBSOLETE. Penetrating at least one phospholipid bilayer of a plasma membrane and consisting of proteoglycan. Also refers to the state of being buried in the bilayer with no exposure outside the bilayer.”
- database_cross_reference “GOC:go_curators”

Added

obsolete proteoglycan integral to plasma membrane definition “OBSOLETE. Penetrating at least one phospholipid bilayer of a plasma membrane and consisting of proteoglycan. Also refers to the state of being buried in the bilayer with no exposure outside the bilayer.”
- database_cross_reference “GOC:curators”

obsolete purine metabolic process `http://purl.obolibrary.org/obo/GO_0006143`

Removed

obsolete purine metabolic process definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete purine metabolic process definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete pyrethroid resistance `http://purl.obolibrary.org/obo/GO_0008165`

Removed

obsolete pyrethroid resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete pyrethroid resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete pyrethroid susceptibility/resistance `http://purl.obolibrary.org/obo/GO_0016357`

Removed

obsolete pyrethroid susceptibility/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete pyrethroid susceptibility/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete pyrimidine metabolic process `http://purl.obolibrary.org/obo/GO_0006205`

Removed

obsolete pyrimidine metabolic process definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete pyrimidine metabolic process definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete pyrimidine nucleobase fermentation `http://purl.obolibrary.org/obo/GO_0043466`

Removed

obsolete pyrimidine nucleobase fermentation has_exact_synonym “pyrimidine base fermentation”
- database_cross_reference “GOC:go_curators”

Added

obsolete pyrimidine nucleobase fermentation has_exact_synonym “pyrimidine base fermentation”
- database_cross_reference “GOC:curators”

obsolete pyroglutamyl-peptidase I activity `http://purl.obolibrary.org/obo/GO_0004219`

Removed

obsolete pyroglutamyl-peptidase I activity definition “OBSOLETE. Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide.”
- database_cross_reference “GOC:curator”

Added

obsolete pyroglutamyl-peptidase I activity definition “OBSOLETE. Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide.”
- database_cross_reference “GOC:curators”

obsolete pyruvate family amino acid metabolic process `http://purl.obolibrary.org/obo/GO_0009078`

Removed

obsolete pyruvate family amino acid metabolic process database_cross_reference “Reactome:R-HSA-8964540”
- label “Alanine metabolism”

obsolete pyruvate fermentation via PFL `http://purl.obolibrary.org/obo/GO_0044814`

Removed

obsolete pyruvate fermentation via PFL label “pyruvate fermentation via PFL”
obsolete pyruvate fermentation via PFL database_cross_reference “MetaCyc:PWY-5480”
obsolete pyruvate fermentation via PFL has_related_synonym “glycolytic fermentation via PFL pathway”
obsolete pyruvate fermentation via PFL definition “The anaerobic metabolic process in which pyruvate is converted to acetyl-CoA and formate by the action of pyruvate formate lyase (PFL), typically occurring in facultative anaerobic bacteria during mixed-acid fermentation.”
- database_cross_reference “PMID:2248795”
- database_cross_reference “PMID:19752030”
obsolete pyruvate fermentation via PFL database_cross_reference “MetaCyc:PWY-5485”
obsolete pyruvate fermentation via PFL narrowMatch PWY-5480
obsolete pyruvate fermentation via PFL narrowMatch PWY-5485
obsolete pyruvate fermentation via PFL EquivalentTo pyruvate fermentation and (has part some formate C-acetyltransferase activity)
obsolete pyruvate fermentation via PFL SubClassOf has part some formate C-acetyltransferase activity
obsolete pyruvate fermentation via PFL SubClassOf pyruvate fermentation

Added

obsolete pyruvate fermentation via PFL label “obsolete pyruvate fermentation via PFL”
obsolete pyruvate fermentation via PFL consider formate C-acetyltransferase activity
obsolete pyruvate fermentation via PFL definition “OBSOLETE. The anaerobic metabolic process in which pyruvate is converted to acetyl-CoA and formate by the action of pyruvate formate lyase (PFL), typically occurring in facultative anaerobic bacteria during mixed-acid fermentation.”
- database_cross_reference “PMID:2248795”
- database_cross_reference “PMID:19752030”
obsolete pyruvate fermentation via PFL term tracker item “https://github.com/geneontology/go-ontology/issues/31679”^^anyURI
obsolete pyruvate fermentation via PFL deprecated true
obsolete pyruvate fermentation via PFL comment “The reason for obsoletion is that this term represents a single enzymatic step (the conversion of pyruvate to acetyl-CoA and formate by pyruvate formate lyase) which is a molecular function, not a biological process.”

obsolete rDNA spacer replication fork barrier binding, bending `http://purl.obolibrary.org/obo/GO_0110035`

Removed

obsolete rDNA spacer replication fork barrier binding, bending definition “The activity of binding selectively, and in a sequence-specific manner, a replication fork barrier found in rDNA spacers, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.”
- database_cross_reference “GOC:vw”
- database_cross_reference “PMID:27035982”
- database_cross_reference “GOC:al”
obsolete rDNA spacer replication fork barrier binding, bending label “rDNA spacer replication fork barrier binding, bending”
obsolete rDNA spacer replication fork barrier binding, bending SubClassOf sequence-specific DNA binding, bending
obsolete rDNA spacer replication fork barrier binding, bending SubClassOf rDNA spacer replication fork barrier binding

Added

obsolete rDNA spacer replication fork barrier binding, bending consider rDNA spacer replication fork barrier binding
obsolete rDNA spacer replication fork barrier binding, bending comment “This term was obsoleted because it is precomposed.”
obsolete rDNA spacer replication fork barrier binding, bending term tracker item “https://github.com/geneontology/go-ontology/issues/31529”^^anyURI
obsolete rDNA spacer replication fork barrier binding, bending consider DNA binding, bending
obsolete rDNA spacer replication fork barrier binding, bending deprecated true
obsolete rDNA spacer replication fork barrier binding, bending definition “OBSOLETE. The activity of binding selectively, and in a sequence-specific manner, a replication fork barrier found in rDNA spacers, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.”
- database_cross_reference “GOC:vw”
- database_cross_reference “PMID:27035982”
- database_cross_reference “GOC:al”
obsolete rDNA spacer replication fork barrier binding, bending label “obsolete rDNA spacer replication fork barrier binding, bending”

obsolete random coil binding `http://purl.obolibrary.org/obo/GO_0006327`

Removed

obsolete random coil binding definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete random coil binding definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete receptor signaling protein serine/threonine kinase signaling protein activity `http://purl.obolibrary.org/obo/GO_0005076`

Removed

obsolete receptor signaling protein serine/threonine kinase signaling protein activity definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete receptor signaling protein serine/threonine kinase signaling protein activity definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete receptor signaling protein serine/threonine phosphatase signaling protein activity `http://purl.obolibrary.org/obo/GO_0005081`

Removed

obsolete receptor signaling protein serine/threonine phosphatase signaling protein activity definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete receptor signaling protein serine/threonine phosphatase signaling protein activity definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete receptor signaling protein tyrosine kinase signaling protein activity `http://purl.obolibrary.org/obo/GO_0008268`

Removed

obsolete receptor signaling protein tyrosine kinase signaling protein activity definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete receptor signaling protein tyrosine kinase signaling protein activity definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete receptor signaling protein tyrosine phosphatase signaling protein activity `http://purl.obolibrary.org/obo/GO_0005082`

Removed

obsolete receptor signaling protein tyrosine phosphatase signaling protein activity definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete receptor signaling protein tyrosine phosphatase signaling protein activity definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete reduced coenzyme F420:heterodisulfide oxidoreductase activity `http://purl.obolibrary.org/obo/GO_0052752`

Removed

obsolete reduced coenzyme F420:heterodisulfide oxidoreductase activity label “reduced coenzyme F420:heterodisulfide oxidoreductase activity”
obsolete reduced coenzyme F420:heterodisulfide oxidoreductase activity has_exact_synonym “F420-dependent heterodisulfide oxidoreductase activity”
- database_cross_reference “PMID:9914308”
obsolete reduced coenzyme F420:heterodisulfide oxidoreductase activity creation date “2011-09-21T04:21:16Z”
obsolete reduced coenzyme F420:heterodisulfide oxidoreductase activity has_exact_synonym “F420H2:heterodisulfide oxidoreductase activity”
obsolete reduced coenzyme F420:heterodisulfide oxidoreductase activity has_exact_synonym “coenzyme F420-dependent heterodisulfide oxidoreductase activity”
- database_cross_reference “PMID:9914308”
obsolete reduced coenzyme F420:heterodisulfide oxidoreductase activity definition “Catalysis of the reaction: reduced coenzyme F420 + CoB-S-S-CoM = coenzyme F420 + CoM-SH + CoB-SH.”
- database_cross_reference “PMID:9914308”
- database_cross_reference “GOC:mengo_curators”
obsolete reduced coenzyme F420:heterodisulfide oxidoreductase activity created by “ai”
obsolete reduced coenzyme F420:heterodisulfide oxidoreductase activity SubClassOf oxidoreductase activity, acting on a sulfur group of donors

Added

obsolete reduced coenzyme F420:heterodisulfide oxidoreductase activity comment “The reason for obsoletion is that this reaction MF has no EC or RHEA xref and no annotations.”
obsolete reduced coenzyme F420:heterodisulfide oxidoreductase activity definition “OBSOLETE. Catalysis of the reaction: reduced coenzyme F420 + CoB-S-S-CoM = coenzyme F420 + CoM-SH + CoB-SH.”
- database_cross_reference “PMID:9914308”
- database_cross_reference “GOC:mengo_curators”
obsolete reduced coenzyme F420:heterodisulfide oxidoreductase activity deprecated true
obsolete reduced coenzyme F420:heterodisulfide oxidoreductase activity label “obsolete reduced coenzyme F420:heterodisulfide oxidoreductase activity”
obsolete reduced coenzyme F420:heterodisulfide oxidoreductase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31518”^^anyURI

obsolete regulation of 1-aminocyclopropane-1-carboxylate metabolic process `http://purl.obolibrary.org/obo/GO_0010602`

Removed

obsolete regulation of 1-aminocyclopropane-1-carboxylate metabolic process definition “Regulation of the chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants.”
- database_cross_reference “PMID:18055613”
obsolete regulation of 1-aminocyclopropane-1-carboxylate metabolic process label “regulation of 1-aminocyclopropane-1-carboxylate metabolic process”
obsolete regulation of 1-aminocyclopropane-1-carboxylate metabolic process EquivalentTo biological regulation and (regulates some obsolete 1-aminocyclopropane-1-carboxylate metabolic process)
obsolete regulation of 1-aminocyclopropane-1-carboxylate metabolic process SubClassOf regulates some obsolete 1-aminocyclopropane-1-carboxylate metabolic process
obsolete regulation of 1-aminocyclopropane-1-carboxylate metabolic process SubClassOf regulation of amino acid metabolic process
obsolete regulation of 1-aminocyclopropane-1-carboxylate metabolic process SubClassOf regulation of small molecule metabolic process

Added

obsolete regulation of 1-aminocyclopropane-1-carboxylate metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31171”^^anyURI
obsolete regulation of 1-aminocyclopropane-1-carboxylate metabolic process label “obsolete regulation of 1-aminocyclopropane-1-carboxylate metabolic process”
obsolete regulation of 1-aminocyclopropane-1-carboxylate metabolic process comment “The reason for obsoletion is that this term was an unnecessary grouping terms and only ‘biosynthetic’ or ‘catabolic’ process should be used.”
obsolete regulation of 1-aminocyclopropane-1-carboxylate metabolic process deprecated true
obsolete regulation of 1-aminocyclopropane-1-carboxylate metabolic process definition “OBSOLETE. Regulation of the chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants.”
- database_cross_reference “PMID:18055613”

obsolete regulation of CD4 production `http://purl.obolibrary.org/obo/GO_0045223`

Removed

obsolete regulation of CD4 production definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of CD4 production definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.”
- database_cross_reference “GOC:curators”

obsolete regulation of DNA-binding transcription factor activity `http://purl.obolibrary.org/obo/GO_0051090`

Removed

obsolete regulation of DNA-binding transcription factor activity database_cross_reference “Reactome:R-HSA-9708530”
- label “Regulation of BACH1 activity”

obsolete regulation of FasL production `http://purl.obolibrary.org/obo/GO_0045219`

Removed

obsolete regulation of FasL production definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL.”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of FasL production definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL.”
- database_cross_reference “GOC:curators”

obsolete regulation of Golgi lumen acidification `http://purl.obolibrary.org/obo/GO_1905526`

Removed

obsolete regulation of Golgi lumen acidification definition “Any process that modulates the frequency, rate or extent of Golgi lumen acidification.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:23447592”
- database_cross_reference “GO_REF:0000058”
obsolete regulation of Golgi lumen acidification label “regulation of Golgi lumen acidification”
obsolete regulation of Golgi lumen acidification EquivalentTo biological regulation and (regulates some Golgi lumen acidification)
obsolete regulation of Golgi lumen acidification SubClassOf obsolete regulation of cellular pH reduction
obsolete regulation of Golgi lumen acidification SubClassOf regulates some Golgi lumen acidification

Added

obsolete regulation of Golgi lumen acidification comment “This term was added in error. Regulating regulation is redundant. Direction is unspecified.”
obsolete regulation of Golgi lumen acidification deprecated true
obsolete regulation of Golgi lumen acidification term tracker item “https://github.com/geneontology/go-ontology/issues/29164”^^anyURI
obsolete regulation of Golgi lumen acidification consider Golgi lumen acidification
obsolete regulation of Golgi lumen acidification definition “OBSOLETE. Any process that modulates the frequency, rate or extent of Golgi lumen acidification.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:23447592”
- database_cross_reference “GO_REF:0000058”
obsolete regulation of Golgi lumen acidification label “obsolete regulation of Golgi lumen acidification”

obsolete regulation of L-proline metabolic process `http://purl.obolibrary.org/obo/GO_2000214`

Removed

obsolete regulation of L-proline metabolic process definition “Any process that modulates the frequency, rate or extent of L-proline metabolic process.”
- database_cross_reference “GOC:sl”
obsolete regulation of L-proline metabolic process label “regulation of L-proline metabolic process”
obsolete regulation of L-proline metabolic process EquivalentTo biological regulation and (regulates some L-proline metabolic process)
obsolete regulation of L-proline metabolic process SubClassOf regulates some L-proline metabolic process
obsolete regulation of L-proline metabolic process SubClassOf regulation of small molecule metabolic process
obsolete regulation of L-proline metabolic process SubClassOf regulation of amino acid metabolic process

Added

obsolete regulation of L-proline metabolic process definition “OBSOLETE. Any process that modulates the frequency, rate or extent of L-proline metabolic process.”
- database_cross_reference “GOC:sl”
obsolete regulation of L-proline metabolic process label “obsolete regulation of L-proline metabolic process”
obsolete regulation of L-proline metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31171”^^anyURI
obsolete regulation of L-proline metabolic process comment “The reason for obsoletion is that this term was an unnecessary grouping terms and only ‘biosynthetic’ or ‘catabolic’ process should be used.”
obsolete regulation of L-proline metabolic process deprecated true

obsolete regulation of L-tryptophan metabolic process `http://purl.obolibrary.org/obo/GO_0090357`

Removed

obsolete regulation of L-tryptophan metabolic process label “regulation of L-tryptophan metabolic process”
obsolete regulation of L-tryptophan metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.”
- database_cross_reference “GOC:tb”
obsolete regulation of L-tryptophan metabolic process EquivalentTo biological regulation and (regulates some L-tryptophan metabolic process)
obsolete regulation of L-tryptophan metabolic process SubClassOf regulation of small molecule metabolic process
obsolete regulation of L-tryptophan metabolic process SubClassOf regulates some L-tryptophan metabolic process
obsolete regulation of L-tryptophan metabolic process SubClassOf regulation of amino acid metabolic process

Added

obsolete regulation of L-tryptophan metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31171”^^anyURI
obsolete regulation of L-tryptophan metabolic process definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.”
- database_cross_reference “GOC:tb”
obsolete regulation of L-tryptophan metabolic process deprecated true
obsolete regulation of L-tryptophan metabolic process comment “The reason for obsoletion is that this term was an unnecessary grouping terms and only ‘biosynthetic’ or ‘catabolic’ process should be used.”
obsolete regulation of L-tryptophan metabolic process label “obsolete regulation of L-tryptophan metabolic process”

obsolete regulation of S phase of mitotic cell cycle `http://purl.obolibrary.org/obo/GO_0007090`

Removed

obsolete regulation of S phase of mitotic cell cycle definition “OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of the progression through the S phase of the mitotic cell cycle.”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of S phase of mitotic cell cycle definition “OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of the progression through the S phase of the mitotic cell cycle.”
- database_cross_reference “GOC:curators”

obsolete regulation of TRAIL receptor 1 biosynthetic process `http://purl.obolibrary.org/obo/GO_0045561`

Removed

obsolete regulation of TRAIL receptor 1 biosynthetic process definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1.”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of TRAIL receptor 1 biosynthetic process definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1.”
- database_cross_reference “GOC:curators”

obsolete regulation of TRAIL receptor 2 biosynthetic process `http://purl.obolibrary.org/obo/GO_0045562`

Removed

obsolete regulation of TRAIL receptor 2 biosynthetic process definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2.”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of TRAIL receptor 2 biosynthetic process definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2.”
- database_cross_reference “GOC:curators”

obsolete regulation of TRAIL receptor biosynthetic process `http://purl.obolibrary.org/obo/GO_0045560`

Removed

obsolete regulation of TRAIL receptor biosynthetic process definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor.”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of TRAIL receptor biosynthetic process definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor.”
- database_cross_reference “GOC:curators”

obsolete regulation of actin phosphorylation `http://purl.obolibrary.org/obo/GO_0043538`

Removed

obsolete regulation of actin phosphorylation definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the transfer of one or more phosphate groups to an actin molecule.”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of actin phosphorylation definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the transfer of one or more phosphate groups to an actin molecule.”
- database_cross_reference “GOC:curators”

obsolete regulation of anti-apoptosis `http://purl.obolibrary.org/obo/GO_0045767`

Removed

obsolete regulation of anti-apoptosis definition “OBSOLETE. Any process that modulates the frequency, rate or extent of anti-apoptosis.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_apoptosis”

Added

obsolete regulation of anti-apoptosis definition “OBSOLETE. Any process that modulates the frequency, rate or extent of anti-apoptosis.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_apoptosis”

obsolete regulation of arginine biosynthetic process via ornithine `http://purl.obolibrary.org/obo/GO_2000013`

Removed

obsolete regulation of arginine biosynthetic process via ornithine label “regulation of arginine biosynthetic process via ornithine”
obsolete regulation of arginine biosynthetic process via ornithine definition “Any process that modulates the frequency, rate or extent of arginine biosynthetic process via ornithine.”
- database_cross_reference “GOC:obol”
obsolete regulation of arginine biosynthetic process via ornithine EquivalentTo biological regulation and (regulates some obsolete L-arginine biosynthetic process via ornithine)
obsolete regulation of arginine biosynthetic process via ornithine SubClassOf regulation of arginine biosynthetic process
obsolete regulation of arginine biosynthetic process via ornithine SubClassOf regulates some obsolete L-arginine biosynthetic process via ornithine

Added

obsolete regulation of arginine biosynthetic process via ornithine deprecated true
obsolete regulation of arginine biosynthetic process via ornithine definition “OBSOLETE. Any process that modulates the frequency, rate or extent of arginine biosynthetic process via ornithine.”
- database_cross_reference “GOC:obol”
obsolete regulation of arginine biosynthetic process via ornithine term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
obsolete regulation of arginine biosynthetic process via ornithine label “obsolete regulation of arginine biosynthetic process via ornithine”
obsolete regulation of arginine biosynthetic process via ornithine term replaced by regulation of arginine biosynthetic process
obsolete regulation of arginine biosynthetic process via ornithine comment “The reason for obsoletion is that these terms represent GO-CAM models.”

obsolete regulation of arginine metabolic process `http://purl.obolibrary.org/obo/GO_0000821`

Removed

obsolete regulation of arginine metabolic process definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of arginine metabolic process definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.”
- database_cross_reference “GOC:curators”

obsolete regulation of calcium in ER `http://purl.obolibrary.org/obo/GO_0006889`

Removed

obsolete regulation of calcium in ER definition “OBSOLETE. Any process that modulates the concentration of calcium in the endoplasmic reticulum.”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of calcium in ER definition “OBSOLETE. Any process that modulates the concentration of calcium in the endoplasmic reticulum.”
- database_cross_reference “GOC:curators”

obsolete regulation of cell shape during vegetative growth phase `http://purl.obolibrary.org/obo/GO_0000903`

Removed

obsolete regulation of cell shape during vegetative growth phase definition “OBSOLETE. Any process that modulates the surface configuration of a cell during the vegetative growth phase. The vegetative growth phase is the growth phase during which single celled organisms reproduce by budding or other asexual methods.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:vw”
- database_cross_reference “GOC:clt”

Added

obsolete regulation of cell shape during vegetative growth phase definition “OBSOLETE. Any process that modulates the surface configuration of a cell during the vegetative growth phase. The vegetative growth phase is the growth phase during which single celled organisms reproduce by budding or other asexual methods.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:vw”
- database_cross_reference “GOC:clt”

obsolete regulation of cellular pH `http://purl.obolibrary.org/obo/GO_0030641`

Removed

obsolete regulation of cellular pH has_exact_synonym “cellular hydrogen ion homeostasis”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:tb”
obsolete regulation of cellular pH definition “Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:tb”
obsolete regulation of cellular pH has_exact_synonym “proton homeostasis”
obsolete regulation of cellular pH label “regulation of cellular pH”
obsolete regulation of cellular pH SubClassOf intracellular monoatomic cation homeostasis
obsolete regulation of cellular pH SubClassOf regulation of pH

Added

obsolete regulation of cellular pH label “obsolete regulation of cellular pH”
obsolete regulation of cellular pH deprecated true
obsolete regulation of cellular pH term tracker item “https://github.com/geneontology/go-ontology/issues/29164”^^anyURI
obsolete regulation of cellular pH term replaced by regulation of intracellular pH
obsolete regulation of cellular pH definition “OBSOLETE. Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:tb”
obsolete regulation of cellular pH comment “The reason for obsoletion is that this term is equivalent to ‘regulation of intracellular pH’ (GO:0051453). The terms ‘cellular pH’ and ‘intracellular pH’ refer to the same concept, and GO:0051453 is the more appropriate term with a proper logical definition.”

obsolete regulation of cellular pH reduction `http://purl.obolibrary.org/obo/GO_0032847`

Removed

obsolete regulation of cellular pH reduction has_exact_synonym “regulation of reduction of cellular pH”
obsolete regulation of cellular pH reduction has_related_synonym “regulation of intracellular acidification”
obsolete regulation of cellular pH reduction has_exact_synonym “regulation of cellular acidification”
obsolete regulation of cellular pH reduction label “regulation of cellular pH reduction”
obsolete regulation of cellular pH reduction definition “Any process that modulates the frequency, rate, or extent of a process that reduces the internal pH of a cell.”
- database_cross_reference “GOC:mah”
obsolete regulation of cellular pH reduction has_exact_synonym “regulation of reduction of pH in cell”
obsolete regulation of cellular pH reduction has_exact_synonym “regulation of intracellular pH reduction”
obsolete regulation of cellular pH reduction has_exact_synonym “regulation of cell pH reduction”
obsolete regulation of cellular pH reduction EquivalentTo biological regulation and (regulates some intracellular pH reduction)
obsolete regulation of cellular pH reduction SubClassOf regulation of biological process
obsolete regulation of cellular pH reduction SubClassOf regulation of intracellular pH
obsolete regulation of cellular pH reduction SubClassOf regulates some intracellular pH reduction

Added

obsolete regulation of cellular pH reduction definition “OBSOLETE. Any process that modulates the frequency, rate, or extent of a process that reduces the internal pH of a cell.”
- database_cross_reference “GOC:mah”
obsolete regulation of cellular pH reduction consider intracellular pH reduction
obsolete regulation of cellular pH reduction consider intracellular pH elevation
obsolete regulation of cellular pH reduction label “obsolete regulation of cellular pH reduction”
obsolete regulation of cellular pH reduction term tracker item “https://github.com/geneontology/go-ontology/issues/29164”^^anyURI
obsolete regulation of cellular pH reduction deprecated true
obsolete regulation of cellular pH reduction comment “This term was obsoleted because it represents ‘regulation of regulation’, which is redundant with direct pH regulation terms.”

obsolete regulation of cysteine metabolic process `http://purl.obolibrary.org/obo/GO_1901494`

Removed

obsolete regulation of cysteine metabolic process definition “Any process that modulates the frequency, rate or extent of cysteine metabolic process.”
- database_cross_reference “GOC:TermGenie”
obsolete regulation of cysteine metabolic process label “regulation of cysteine metabolic process”
obsolete regulation of cysteine metabolic process EquivalentTo biological regulation and (regulates some obsolete cysteine metabolic process)
obsolete regulation of cysteine metabolic process SubClassOf regulation of small molecule metabolic process
obsolete regulation of cysteine metabolic process SubClassOf regulation of sulfur metabolic process
obsolete regulation of cysteine metabolic process SubClassOf regulation of amino acid metabolic process
obsolete regulation of cysteine metabolic process SubClassOf regulates some obsolete cysteine metabolic process

Added

obsolete regulation of cysteine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31281”^^anyURI
obsolete regulation of cysteine metabolic process label “obsolete regulation of cysteine metabolic process”
obsolete regulation of cysteine metabolic process comment “This term was obsoleted because it was an unnecessray grouping term.”
obsolete regulation of cysteine metabolic process deprecated true
obsolete regulation of cysteine metabolic process definition “OBSOLETE. Any process that modulates the frequency, rate or extent of cysteine metabolic process.”
- database_cross_reference “GOC:TermGenie”

obsolete regulation of cysteine-type endopeptidase activity involved in apoptotic process `http://purl.obolibrary.org/obo/GO_0043281`

Removed

obsolete regulation of cysteine-type endopeptidase activity involved in apoptotic process database_cross_reference “Reactome:R-HSA-205025”
- label “NADE modulates death signalling”

obsolete regulation of cytoskeleton `http://purl.obolibrary.org/obo/GO_0007011`

Removed

obsolete regulation of cytoskeleton definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton.”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of cytoskeleton definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton.”
- database_cross_reference “GOC:curators”

obsolete regulation of early endosome to recycling endosome transport `http://purl.obolibrary.org/obo/GO_1902954`

Removed

obsolete regulation of early endosome to recycling endosome transport definition “Any process that modulates the frequency, rate or extent of early endosome to recycling endosome transport.”
- database_cross_reference “PMID:22621900”
- database_cross_reference “GOC:sjp”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “GO_REF:0000058”
obsolete regulation of early endosome to recycling endosome transport label “regulation of early endosome to recycling endosome transport”
obsolete regulation of early endosome to recycling endosome transport EquivalentTo biological regulation and (regulates some obsolete early endosome to recycling endosome transport)
obsolete regulation of early endosome to recycling endosome transport SubClassOf regulates some obsolete early endosome to recycling endosome transport
obsolete regulation of early endosome to recycling endosome transport SubClassOf regulation of vesicle-mediated transport
obsolete regulation of early endosome to recycling endosome transport SubClassOf regulation of intracellular transport

Added

obsolete regulation of early endosome to recycling endosome transport deprecated true
obsolete regulation of early endosome to recycling endosome transport term replaced by regulation of endocytic recycling
obsolete regulation of early endosome to recycling endosome transport comment “This term is described by another GO term”
obsolete regulation of early endosome to recycling endosome transport term tracker item “https://github.com/geneontology/go-ontology/issues/31240”^^anyURI
obsolete regulation of early endosome to recycling endosome transport definition “OBSOLETE. Any process that modulates the frequency, rate or extent of early endosome to recycling endosome transport.”
- database_cross_reference “PMID:22621900”
- database_cross_reference “GOC:sjp”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “GO_REF:0000058”
obsolete regulation of early endosome to recycling endosome transport label “obsolete regulation of early endosome to recycling endosome transport”

obsolete regulation of endocytosis by exocyst localization `http://purl.obolibrary.org/obo/GO_0051600`

Removed

obsolete regulation of endocytosis by exocyst localization label “regulation of endocytosis by exocyst localization”
obsolete regulation of endocytosis by exocyst localization definition “Any process in which an exocyst is transported to, or maintained in, a specific location that results in the modulation of endocytosis. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:ai”
obsolete regulation of endocytosis by exocyst localization EquivalentTo exocyst localization and (regulates some endocytosis)
obsolete regulation of endocytosis by exocyst localization SubClassOf regulation of endocytosis
obsolete regulation of endocytosis by exocyst localization SubClassOf exocyst localization

Added

obsolete regulation of endocytosis by exocyst localization comment “The reason for obsoletion is that this represents a phenotype.”
obsolete regulation of endocytosis by exocyst localization definition “OBSOLETE. Any process in which an exocyst is transported to, or maintained in, a specific location that results in the modulation of endocytosis. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:ai”
obsolete regulation of endocytosis by exocyst localization label “obsolete regulation of endocytosis by exocyst localization”
obsolete regulation of endocytosis by exocyst localization term tracker item “https://github.com/geneontology/go-ontology/issues/31201”^^anyURI
obsolete regulation of endocytosis by exocyst localization deprecated true

obsolete regulation of epidermal growth factor-activated receptor activity `http://purl.obolibrary.org/obo/GO_0007176`

Removed

obsolete regulation of epidermal growth factor-activated receptor activity definition “OBSOLETE. Any process that modulates the frequency, rate or extent of EGF-activated receptor activity.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of epidermal growth factor-activated receptor activity definition “OBSOLETE. Any process that modulates the frequency, rate or extent of EGF-activated receptor activity.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”

obsolete regulation of flagellum assembly `http://purl.obolibrary.org/obo/GO_0030092`

Removed

obsolete regulation of flagellum assembly definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the formation of a flagellum.”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of flagellum assembly definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the formation of a flagellum.”
- database_cross_reference “GOC:curators”

obsolete regulation of glutamate metabolic process `http://purl.obolibrary.org/obo/GO_2000211`

Removed

obsolete regulation of glutamate metabolic process definition “Any process that modulates the frequency, rate or extent of glutamate metabolic process.”
- database_cross_reference “GOC:sl”
obsolete regulation of glutamate metabolic process label “regulation of glutamate metabolic process”
obsolete regulation of glutamate metabolic process EquivalentTo biological regulation and (regulates some glutamate metabolic process)
obsolete regulation of glutamate metabolic process SubClassOf regulates some glutamate metabolic process
obsolete regulation of glutamate metabolic process SubClassOf regulation of small molecule metabolic process
obsolete regulation of glutamate metabolic process SubClassOf regulation of amino acid metabolic process

Added

obsolete regulation of glutamate metabolic process comment “The reason for obsoletion is that this term was an unnecessary grouping terms and only ‘biosynthetic’ or ‘catabolic’ process should be used.”
obsolete regulation of glutamate metabolic process deprecated true
obsolete regulation of glutamate metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31171”^^anyURI
obsolete regulation of glutamate metabolic process label “obsolete regulation of glutamate metabolic process”
obsolete regulation of glutamate metabolic process definition “OBSOLETE. Any process that modulates the frequency, rate or extent of glutamate metabolic process.”
- database_cross_reference “GOC:sl”

obsolete regulation of glutamine family amino acid metabolic process `http://purl.obolibrary.org/obo/GO_0000820`

Removed

obsolete regulation of glutamine family amino acid metabolic process definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of glutamine family amino acid metabolic process definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.”
- database_cross_reference “GOC:curators”

obsolete regulation of initiation of acetate catabolic process by acetate `http://purl.obolibrary.org/obo/GO_0045147`

Removed

obsolete regulation of initiation of acetate catabolic process by acetate definition “OBSOLETE. Any process that modulates the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate.”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of initiation of acetate catabolic process by acetate definition “OBSOLETE. Any process that modulates the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate.”
- database_cross_reference “GOC:curators”

obsolete regulation of juvenile hormone metabolic process `http://purl.obolibrary.org/obo/GO_0007556`

Removed

obsolete regulation of juvenile hormone metabolic process definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone.”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of juvenile hormone metabolic process definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone.”
- database_cross_reference “GOC:curators”

obsolete regulation of light-activated channel activity `http://purl.obolibrary.org/obo/GO_0016061`

Removed

obsolete regulation of light-activated channel activity definition “OBSOLETE. Any process that modulates the frequency, rate or extent of light-activated channel activity.”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of light-activated channel activity definition “OBSOLETE. Any process that modulates the frequency, rate or extent of light-activated channel activity.”
- database_cross_reference “GOC:curators”

obsolete regulation of low-density lipoprotein particle receptor biosynthetic process `http://purl.obolibrary.org/obo/GO_0045714`

Removed

obsolete regulation of low-density lipoprotein particle receptor biosynthetic process definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein particle receptors.”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of low-density lipoprotein particle receptor biosynthetic process definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein particle receptors.”
- database_cross_reference “GOC:curators”

obsolete regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine `http://purl.obolibrary.org/obo/GO_2001194`

Removed

obsolete regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine label “regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine”
obsolete regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine definition “Any process that modulates the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine.”
- database_cross_reference “GOC:obol”
obsolete regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine EquivalentTo biological regulation and (regulates some obsolete L-lysine biosynthetic process via alpha-aminoadipate and saccharopine)
obsolete regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine SubClassOf regulates some obsolete L-lysine biosynthetic process via alpha-aminoadipate and saccharopine
obsolete regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine SubClassOf regulation of lysine biosynthetic process via aminoadipic acid

Added

obsolete regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI
obsolete regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine comment “The reason for obsoletion is that this term was created unnecessarily.”
obsolete regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine definition “OBSOLETE. Any process that modulates the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine.”
- database_cross_reference “GOC:obol”
obsolete regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine deprecated true
obsolete regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine label “obsolete regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine”

obsolete regulation of lysosomal lumen pH `http://purl.obolibrary.org/obo/GO_0035751`

Removed

obsolete regulation of lysosomal lumen pH label “regulation of lysosomal lumen pH”
obsolete regulation of lysosomal lumen pH definition “Any process that modulates the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion.”
- database_cross_reference “GOC:rph”
obsolete regulation of lysosomal lumen pH SubClassOf part of some lysosome organization
obsolete regulation of lysosomal lumen pH SubClassOf regulation of intracellular pH

Added

obsolete regulation of lysosomal lumen pH term tracker item “https://github.com/geneontology/go-ontology/issues/29164”^^anyURI
obsolete regulation of lysosomal lumen pH definition “OBSOLETE. Any process that modulates the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion.”
- database_cross_reference “GOC:rph”
obsolete regulation of lysosomal lumen pH consider lysosomal lumen acidification
obsolete regulation of lysosomal lumen pH label “obsolete regulation of lysosomal lumen pH”
obsolete regulation of lysosomal lumen pH consider lysosomal lumen pH elevation
obsolete regulation of lysosomal lumen pH comment “The reason for obsoletion is that this term was an unnecessary grouping term.”
obsolete regulation of lysosomal lumen pH deprecated true

obsolete regulation of myosin light chain kinase activity `http://purl.obolibrary.org/obo/GO_0035504`

Removed

obsolete regulation of myosin light chain kinase activity definition “OBSOLETE. Any process that modulates the frequency, rate or extent of myosin light chain kinase activity.”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of myosin light chain kinase activity definition “OBSOLETE. Any process that modulates the frequency, rate or extent of myosin light chain kinase activity.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:bf”

obsolete regulation of myosin-light-chain-phosphatase activity `http://purl.obolibrary.org/obo/GO_0035507`

Removed

obsolete regulation of myosin-light-chain-phosphatase activity definition “OBSOLETE. Any process that modulates the frequency, rate or extent of myosin-light-chain-phosphatase activity.”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of myosin-light-chain-phosphatase activity definition “OBSOLETE. Any process that modulates the frequency, rate or extent of myosin-light-chain-phosphatase activity.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:bf”

obsolete regulation of nitric oxide mediated signal transduction `http://purl.obolibrary.org/obo/GO_0010749`

Removed

obsolete regulation of nitric oxide mediated signal transduction label “regulation of nitric oxide mediated signal transduction”
obsolete regulation of nitric oxide mediated signal transduction has_exact_synonym “regulation of nitric oxide-mediated signal transduction”
obsolete regulation of nitric oxide mediated signal transduction definition “Any process that modulates the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO).”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:BHF”
obsolete regulation of nitric oxide mediated signal transduction EquivalentTo biological regulation and (regulates some obsolete nitric oxide mediated signal transduction)
obsolete regulation of nitric oxide mediated signal transduction SubClassOf regulation of intracellular signal transduction
obsolete regulation of nitric oxide mediated signal transduction SubClassOf regulates some obsolete nitric oxide mediated signal transduction

Added

obsolete regulation of nitric oxide mediated signal transduction comment “The reason for obsoletion is that this term has been inconsistently used and NO signaling proceeds via cGMP, so the more specific replacement term is preferred.”
obsolete regulation of nitric oxide mediated signal transduction label “obsolete regulation of nitric oxide mediated signal transduction”
obsolete regulation of nitric oxide mediated signal transduction deprecated true
obsolete regulation of nitric oxide mediated signal transduction definition “OBSOLETE. Any process that modulates the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO).”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:BHF”
obsolete regulation of nitric oxide mediated signal transduction term replaced by regulation of nitric oxide-cGMP mediated signal transduction
obsolete regulation of nitric oxide mediated signal transduction term tracker item “https://github.com/geneontology/go-ontology/issues/26613”^^anyURI

obsolete regulation of ornithine metabolic process `http://purl.obolibrary.org/obo/GO_0090368`

Removed

obsolete regulation of ornithine metabolic process definition “Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:jp”
obsolete regulation of ornithine metabolic process label “regulation of ornithine metabolic process”
obsolete regulation of ornithine metabolic process EquivalentTo biological regulation and (regulates some ornithine metabolic process)
obsolete regulation of ornithine metabolic process SubClassOf regulation of small molecule metabolic process
obsolete regulation of ornithine metabolic process SubClassOf regulation of amino acid metabolic process
obsolete regulation of ornithine metabolic process SubClassOf regulates some ornithine metabolic process

Added

obsolete regulation of ornithine metabolic process comment “The reason for obsoletion is that this term was an unnecessary grouping terms and only ‘biosynthetic’ or ‘catabolic’ process should be used.”
obsolete regulation of ornithine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31171”^^anyURI
obsolete regulation of ornithine metabolic process deprecated true
obsolete regulation of ornithine metabolic process definition “OBSOLETE. Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:jp”
obsolete regulation of ornithine metabolic process database_cross_reference “Reactome:R-HSA-350562”
- label “Regulation of ornithine decarboxylase (ODC)”
obsolete regulation of ornithine metabolic process label “obsolete regulation of ornithine metabolic process”

obsolete regulation of phosphate metabolic process `http://purl.obolibrary.org/obo/GO_0019220`

Removed

obsolete regulation of phosphate metabolic process definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates.”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of phosphate metabolic process definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates.”
- database_cross_reference “GOC:curators”

obsolete regulation of pteridine metabolic process `http://purl.obolibrary.org/obo/GO_0042068`

Removed

obsolete regulation of pteridine metabolic process definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pteridine.”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of pteridine metabolic process definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pteridine.”
- database_cross_reference “GOC:curators”

obsolete regulation of pyrimidine nucleobase metabolic process `http://purl.obolibrary.org/obo/GO_0006142`

Removed

obsolete regulation of pyrimidine nucleobase metabolic process definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases.”
- database_cross_reference “GOC:go_curators”
obsolete regulation of pyrimidine nucleobase metabolic process has_exact_synonym “regulation of pyrimidine base metabolic process”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of pyrimidine nucleobase metabolic process has_exact_synonym “regulation of pyrimidine base metabolic process”
- database_cross_reference “GOC:curators”
obsolete regulation of pyrimidine nucleobase metabolic process definition “OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases.”
- database_cross_reference “GOC:curators”

obsolete regulation of recombination within rDNA repeats `http://purl.obolibrary.org/obo/GO_0045865`

Removed

obsolete regulation of recombination within rDNA repeats definition “OBSOLETE. Any process that modulates the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

obsolete regulation of recombination within rDNA repeats definition “OBSOLETE. Any process that modulates the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

obsolete regulation of rhodopsin gene expression `http://purl.obolibrary.org/obo/GO_0007468`

Removed

obsolete regulation of rhodopsin gene expression definition “OBSOLETE. Any process that modulates the frequency, rate or extent of rhodopsin gene expression. This includes transcriptional, translational, or posttranslational regulation.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

obsolete regulation of rhodopsin gene expression definition “OBSOLETE. Any process that modulates the frequency, rate or extent of rhodopsin gene expression. This includes transcriptional, translational, or posttranslational regulation.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

obsolete regulation of survival gene product expression `http://purl.obolibrary.org/obo/GO_0045884`

Removed

obsolete regulation of survival gene product expression definition “OBSOLETE. Any process that modulates the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:mtg_apoptosis”

Added

obsolete regulation of survival gene product expression definition “OBSOLETE. Any process that modulates the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:mtg_apoptosis”

obsolete regulation of transcription by pheromones `http://purl.obolibrary.org/obo/GO_0009373`

Removed

obsolete regulation of transcription by pheromones definition “OBSOLETE. Any process involving pheromones that modulates the frequency, rate or extent of transcription.”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of transcription by pheromones definition “OBSOLETE. Any process involving pheromones that modulates the frequency, rate or extent of transcription.”
- database_cross_reference “GOC:curators”

obsolete regulation of transcription during mitotic cell cycle `http://purl.obolibrary.org/obo/GO_0045896`

Removed

obsolete regulation of transcription during mitotic cell cycle definition “OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of transcription that occurs during the mitotic cell cycle.”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of transcription during mitotic cell cycle definition “OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of transcription that occurs during the mitotic cell cycle.”
- database_cross_reference “GOC:curators”

obsolete regulation of transcription from RNA polymerase I promoter during mitotic cell cycle `http://purl.obolibrary.org/obo/GO_0046017`

Removed

obsolete regulation of transcription from RNA polymerase I promoter during mitotic cell cycle definition “OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter that occurs during the mitotic cell cycle.”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of transcription from RNA polymerase I promoter during mitotic cell cycle definition “OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter that occurs during the mitotic cell cycle.”
- database_cross_reference “GOC:curators”

obsolete regulation of transcription from RNA polymerase II promoter by pheromones `http://purl.obolibrary.org/obo/GO_0046019`

Removed

obsolete regulation of transcription from RNA polymerase II promoter by pheromones definition “OBSOLETE. Any process involving pheromones that modulates the frequency, rate or extent or transcription from an RNA polymerase II promoter.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:txnOH”

Added

obsolete regulation of transcription from RNA polymerase II promoter by pheromones definition “OBSOLETE. Any process involving pheromones that modulates the frequency, rate or extent or transcription from an RNA polymerase II promoter.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:txnOH”

obsolete regulation of transcription from RNA polymerase II promoter during mitotic cell cycle `http://purl.obolibrary.org/obo/GO_0046021`

Removed

obsolete regulation of transcription from RNA polymerase II promoter during mitotic cell cycle definition “OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that occurs during the mitotic cell cycle.”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of transcription from RNA polymerase II promoter during mitotic cell cycle definition “OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that occurs during the mitotic cell cycle.”
- database_cross_reference “GOC:curators”

obsolete regulation of transcription from RNA polymerase III promoter during mitotic cell cycle `http://purl.obolibrary.org/obo/GO_0046023`

Removed

obsolete regulation of transcription from RNA polymerase III promoter during mitotic cell cycle definition “OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase III promoter that occurs during the mitotic cell cycle.”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of transcription from RNA polymerase III promoter during mitotic cell cycle definition “OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase III promoter that occurs during the mitotic cell cycle.”
- database_cross_reference “GOC:curators”

obsolete regulation of transcription involved in meiotic cell cycle `http://purl.obolibrary.org/obo/GO_0051037`

Removed

obsolete regulation of transcription involved in meiotic cell cycle definition “OBSOLETE. Any process that modulates the frequency, rate or extent of transcription as part of a meiotic cell cycle.”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of transcription involved in meiotic cell cycle definition “OBSOLETE. Any process that modulates the frequency, rate or extent of transcription as part of a meiotic cell cycle.”
- database_cross_reference “GOC:curators”

obsolete regulation of transcription of homeotic gene (Polycomb group) `http://purl.obolibrary.org/obo/GO_0045888`

Removed

obsolete regulation of transcription of homeotic gene (Polycomb group) definition “OBSOLETE. Any process that modulates the frequency, rate or extent of transcription of homeotic genes of the Polycomb group.”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of transcription of homeotic gene (Polycomb group) definition “OBSOLETE. Any process that modulates the frequency, rate or extent of transcription of homeotic genes of the Polycomb group.”
- database_cross_reference “GOC:curators”

obsolete regulation of transcription of homeotic gene (trithorax group) `http://purl.obolibrary.org/obo/GO_0045890`

Removed

obsolete regulation of transcription of homeotic gene (trithorax group) definition “OBSOLETE. Any process that modulates the frequency, rate or extent of transcription of homeotic genes of the trithorax group.”
- database_cross_reference “GOC:go_curators”

Added

obsolete regulation of transcription of homeotic gene (trithorax group) definition “OBSOLETE. Any process that modulates the frequency, rate or extent of transcription of homeotic genes of the trithorax group.”
- database_cross_reference “GOC:curators”

obsolete reproduction `http://purl.obolibrary.org/obo/GO_0000003`

Removed

obsolete reproduction definition “OBSOLETE. The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:isa_complete”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

obsolete reproduction definition “OBSOLETE. The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:isa_complete”
- database_cross_reference “ISBN:0198506732”

obsolete resistance to pathogenic bacteria `http://purl.obolibrary.org/obo/GO_0009619`

Removed

obsolete resistance to pathogenic bacteria definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete resistance to pathogenic bacteria definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete resistance to pathogenic fungi `http://purl.obolibrary.org/obo/GO_0009622`

Removed

obsolete resistance to pathogenic fungi definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete resistance to pathogenic fungi definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete resistance to pathogenic protozoa `http://purl.obolibrary.org/obo/GO_0001564`

Removed

obsolete resistance to pathogenic protozoa definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete resistance to pathogenic protozoa definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete response to cocaine (sensu Insecta) `http://purl.obolibrary.org/obo/GO_0008341`

Removed

obsolete response to cocaine (sensu Insecta) definition “OBSOLETE. A change in state or activity of a mature individual as the result of a cocaine stimulus. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557).”
- database_cross_reference “GOC:jid”
- database_cross_reference “GOC:go_curators”

Added

obsolete response to cocaine (sensu Insecta) definition “OBSOLETE. A change in state or activity of a mature individual as the result of a cocaine stimulus. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557).”
- database_cross_reference “GOC:jid”
- database_cross_reference “GOC:curators”

obsolete response to ethanol (sensu Insecta) `http://purl.obolibrary.org/obo/GO_0045473`

Removed

obsolete response to ethanol (sensu Insecta) definition “OBSOLETE. A change in state or activity of an insect (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.”
- database_cross_reference “GOC:jid”
- database_cross_reference “GOC:go_curators”

Added

obsolete response to ethanol (sensu Insecta) definition “OBSOLETE. A change in state or activity of an insect (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.”
- database_cross_reference “GOC:jid”
- database_cross_reference “GOC:curators”

obsolete response to ether (sensu Insecta) `http://purl.obolibrary.org/obo/GO_0045474`

Removed

obsolete response to ether (sensu Insecta) definition “OBSOLETE. A change in state or activity of an insect (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ether stimulus.”
- database_cross_reference “GOC:jid”
- database_cross_reference “GOC:go_curators”

Added

obsolete response to ether (sensu Insecta) definition “OBSOLETE. A change in state or activity of an insect (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ether stimulus.”
- database_cross_reference “GOC:jid”
- database_cross_reference “GOC:curators”

obsolete response to extracellular stimulus `http://purl.obolibrary.org/obo/GO_0009991`

Removed

obsolete response to extracellular stimulus definition “OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.”
- database_cross_reference “GOC:go_curators”

Added

obsolete response to extracellular stimulus definition “OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.”
- database_cross_reference “GOC:curators”

obsolete ribonucleoside monophosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009161`

Removed

obsolete ribonucleoside monophosphate metabolic process definition “OBSOLETE. The chemical reactions and pathways involving a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

obsolete ribonucleoside monophosphate metabolic process definition “OBSOLETE. The chemical reactions and pathways involving a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

obsolete ribonucleoside triphosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009199`

Removed

obsolete ribonucleoside triphosphate metabolic process definition “OBSOLETE. The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

obsolete ribonucleoside triphosphate metabolic process definition “OBSOLETE. The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

obsolete sarcosine biosynthetic process `http://purl.obolibrary.org/obo/GO_1901054`

Removed

obsolete sarcosine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of sarcosine.”
- database_cross_reference “GOC:yaf”
- database_cross_reference “PMID:31402327”
- database_cross_reference “GOC:TermGenie”
obsolete sarcosine biosynthetic process label “sarcosine biosynthetic process”
obsolete sarcosine biosynthetic process SubClassOf alpha-amino acid biosynthetic process
obsolete sarcosine biosynthetic process SubClassOf non-proteinogenic amino acid biosynthetic process
obsolete sarcosine biosynthetic process SubClassOf obsolete sarcosine metabolic process
obsolete sarcosine biosynthetic process SubClassOf modified amino acid biosynthetic process

Added

obsolete sarcosine biosynthetic process consider glycine biosynthetic process
obsolete sarcosine biosynthetic process consider glycine catabolic process
obsolete sarcosine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31510”^^anyURI
obsolete sarcosine biosynthetic process deprecated true
obsolete sarcosine biosynthetic process comment “This term was obsoleted because sarcosine is an intermediate and byproduct in glycine synthesis and degradation.”
obsolete sarcosine biosynthetic process label “obsolete sarcosine biosynthetic process”
obsolete sarcosine biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of sarcosine.”
- database_cross_reference “GOC:yaf”
- database_cross_reference “PMID:31402327”
- database_cross_reference “GOC:TermGenie”

obsolete sarcosine catabolic process `http://purl.obolibrary.org/obo/GO_1901053`

Removed

obsolete sarcosine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of sarcosine.”
- database_cross_reference “GOC:yaf”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:17951379”
obsolete sarcosine catabolic process label “sarcosine catabolic process”
obsolete sarcosine catabolic process SubClassOf obsolete sarcosine metabolic process
obsolete sarcosine catabolic process SubClassOf alpha-amino acid catabolic process
obsolete sarcosine catabolic process SubClassOf modified amino acid catabolic process
obsolete sarcosine catabolic process SubClassOf non-proteinogenic amino acid catabolic process

Added

obsolete sarcosine catabolic process label “obsolete sarcosine catabolic process”
obsolete sarcosine catabolic process deprecated true
obsolete sarcosine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31361”^^anyURI
obsolete sarcosine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of sarcosine.”
- database_cross_reference “GOC:yaf”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:17951379”
obsolete sarcosine catabolic process comment “This term was obsoleted because there is no evidence that a specific pathway for sarcosine degradation exists.”

obsolete sarcosine metabolic process `http://purl.obolibrary.org/obo/GO_1901052`

Removed

obsolete sarcosine metabolic process label “sarcosine metabolic process”
obsolete sarcosine metabolic process definition “The chemical reactions and pathways involving sarcosine.”
- database_cross_reference “GOC:yaf”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:17951379”
obsolete sarcosine metabolic process SubClassOf non-proteinogenic amino acid metabolic process
obsolete sarcosine metabolic process SubClassOf modified amino acid metabolic process
obsolete sarcosine metabolic process SubClassOf alpha-amino acid metabolic process

Added

obsolete sarcosine metabolic process label “obsolete sarcosine metabolic process”
obsolete sarcosine metabolic process comment “This term was obsoleted because sarcosine is an intermediate and byproduct in glycine synthesis and degradation.”
obsolete sarcosine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving sarcosine.”
- database_cross_reference “GOC:yaf”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:17951379”
obsolete sarcosine metabolic process consider glycine biosynthetic process
obsolete sarcosine metabolic process deprecated true
obsolete sarcosine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31510”^^anyURI
obsolete sarcosine metabolic process consider glycine catabolic process

obsolete satellite DNA binding `http://purl.obolibrary.org/obo/GO_0006329`

Removed

obsolete satellite DNA binding definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete satellite DNA binding definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete secondary active organic cation transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0008513`

Removed

obsolete secondary active organic cation transmembrane transporter activity database_cross_reference “Reactome:R-HSA-549241”
- label “SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol”

obsolete secretory vesicle membrane `http://purl.obolibrary.org/obo/GO_0005804`

Removed

obsolete secretory vesicle membrane definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete secretory vesicle membrane definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete selenocysteine metabolic process `http://purl.obolibrary.org/obo/GO_0016259`

Removed

obsolete selenocysteine metabolic process definition “The chemical reactions and pathways involving selenocysteine, an essential component of glutathione peroxidase and some other proteins.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”
obsolete selenocysteine metabolic process label “selenocysteine metabolic process”
obsolete selenocysteine metabolic process SubClassOf alpha-amino acid metabolic process

Added

obsolete selenocysteine metabolic process consider L-selenocysteine catabolic process
obsolete selenocysteine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving selenocysteine, an essential component of glutathione peroxidase and some other proteins.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”
obsolete selenocysteine metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
obsolete selenocysteine metabolic process deprecated true
obsolete selenocysteine metabolic process consider L-selenocysteine biosynthetic process
obsolete selenocysteine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI
obsolete selenocysteine metabolic process label “obsolete selenocysteine metabolic process”

obsolete septin assembly and septum formation `http://purl.obolibrary.org/obo/GO_0000094`

Removed

obsolete septin assembly and septum formation definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete septin assembly and septum formation definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete sequestering of actin monomers `http://purl.obolibrary.org/obo/GO_0042989`

Removed

obsolete sequestering of actin monomers definition “OBSOLETE. The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers.”
- database_cross_reference “GOC:go_curators”

Added

obsolete sequestering of actin monomers definition “OBSOLETE. The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers.”
- database_cross_reference “GOC:curators”

obsolete sigma virus replication `http://purl.obolibrary.org/obo/GO_0008167`

Removed

obsolete sigma virus replication definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete sigma virus replication definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete signal peptide processing `http://purl.obolibrary.org/obo/GO_0006465`

Removed

obsolete signal peptide processing database_cross_reference “Reactome:R-HSA-159782”
- label “Removal of aminoterminal propeptides from gamma-carboxylated proteins”

obsolete signal transducer activity `http://purl.obolibrary.org/obo/GO_0004871`

Removed

obsolete signal transducer activity definition “OBSOLETE. Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.”
- database_cross_reference “GOC:go_curators”

Added

obsolete signal transducer activity definition “OBSOLETE. Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.”
- database_cross_reference “GOC:curators”

obsolete single-stranded DNA binding `http://purl.obolibrary.org/obo/GO_0006330`

Removed

obsolete single-stranded DNA binding definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete single-stranded DNA binding definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete small molecule transport `http://purl.obolibrary.org/obo/GO_0006832`

Removed

obsolete small molecule transport definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete small molecule transport definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete small-molecule carrier or transporter `http://purl.obolibrary.org/obo/GO_0005468`

Removed

obsolete small-molecule carrier or transporter definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete small-molecule carrier or transporter definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete sodium-dependent organic anion transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0043250`

Removed

obsolete sodium-dependent organic anion transmembrane transporter activity definition “OBSOLETE. Enables the transfer of organic anions from one side of a membrane to the other, in a sodium dependent manner.”
- database_cross_reference “GOC:go_curators”

Added

obsolete sodium-dependent organic anion transmembrane transporter activity definition “OBSOLETE. Enables the transfer of organic anions from one side of a membrane to the other, in a sodium dependent manner.”
- database_cross_reference “GOC:curators”

obsolete sodium-independent organic anion transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015347`

Removed

obsolete sodium-independent organic anion transmembrane transporter activity database_cross_reference “Reactome:R-HSA-879584”
- label “SLCO3A1 isoform 1 has abroad substrate specificity”
obsolete sodium-independent organic anion transmembrane transporter activity database_cross_reference “Reactome:R-HSA-561059”
- label “OAT2 and OAT4 mediate transport of sulphate conjugates”
obsolete sodium-independent organic anion transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9661723”
- label “SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)”
obsolete sodium-independent organic anion transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9661397”
- label “SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)”
obsolete sodium-independent organic anion transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9661446”
- label “BMG, BDG translocates from ER lumen to cytosol”
obsolete sodium-independent organic anion transmembrane transporter activity database_cross_reference “Reactome:R-HSA-879594”
- label “SLCO4C1 mediates the transport of digoxin”
obsolete sodium-independent organic anion transmembrane transporter activity database_cross_reference “Reactome:R-HSA-879562”
- label “SLCO2B1 has a narrow substrate specificity”
obsolete sodium-independent organic anion transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9749607”
- label “SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells”
obsolete sodium-independent organic anion transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9749583”
- label “SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes”
obsolete sodium-independent organic anion transmembrane transporter activity definition “OBSOLETE. Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner.”
- database_cross_reference “GOC:go_curators”
obsolete sodium-independent organic anion transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9661799”
- label “SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)”
obsolete sodium-independent organic anion transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9757010”
- label “SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol”

Added

obsolete sodium-independent organic anion transmembrane transporter activity definition “OBSOLETE. Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner.”
- database_cross_reference “GOC:curators”

obsolete sodium/potassium transport `http://purl.obolibrary.org/obo/GO_0006815`

Removed

obsolete sodium/potassium transport definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete sodium/potassium transport definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete sphingosine hydroxylase activity `http://purl.obolibrary.org/obo/GO_0000170`

Removed

obsolete sphingosine hydroxylase activity database_cross_reference “Reactome:R-HSA-428260”
- label “DEGS2 oxygenates dihydroceramide”

obsolete storage protein `http://purl.obolibrary.org/obo/GO_0005187`

Removed

obsolete storage protein definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete storage protein definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete storage protein of fat body (sensu Insecta) `http://purl.obolibrary.org/obo/GO_0008041`

Removed

obsolete storage protein of fat body (sensu Insecta) definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete storage protein of fat body (sensu Insecta) definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete streptomycin susceptibility/resistance `http://purl.obolibrary.org/obo/GO_0019881`

Removed

obsolete streptomycin susceptibility/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete streptomycin susceptibility/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete sucrose catabolic process via 3’-ketosucrose `http://purl.obolibrary.org/obo/GO_0019574`

Removed

obsolete sucrose catabolic process via 3’-ketosucrose label “sucrose catabolic process via 3’-ketosucrose”
obsolete sucrose catabolic process via 3’-ketosucrose database_cross_reference “MetaCyc:SUCROSEUTIL2-PWY”
obsolete sucrose catabolic process via 3’-ketosucrose definition “The chemical reactions and pathways resulting in the breakdown of sucrose, which proceeds via the conversion of sucrose to 3’-ketosucrose. 3’-ketosucrose is hydrolyzed to 3-ketoglucose and fructose, and the 3-ketoglucose is then be converted to glucose.”
- database_cross_reference “GOC:bf”
- database_cross_reference “MetaCyc:SUCROSEUTIL2-PWY”
- database_cross_reference “GOC:dgf”
obsolete sucrose catabolic process via 3’-ketosucrose SubClassOf has part some fructokinase activity
obsolete sucrose catabolic process via 3’-ketosucrose SubClassOf organophosphate metabolic process
obsolete sucrose catabolic process via 3’-ketosucrose SubClassOf has part some glucoside 3-dehydrogenase activity
obsolete sucrose catabolic process via 3’-ketosucrose SubClassOf carbohydrate derivative metabolic process
obsolete sucrose catabolic process via 3’-ketosucrose SubClassOf sucrose catabolic process
obsolete sucrose catabolic process via 3’-ketosucrose SubClassOf glucose metabolic process
obsolete sucrose catabolic process via 3’-ketosucrose SubClassOf phosphate-containing compound metabolic process
obsolete sucrose catabolic process via 3’-ketosucrose SubClassOf has part some obsolete 3-ketoglucose-reductase activity

Added

obsolete sucrose catabolic process via 3’-ketosucrose term replaced by sucrose catabolic process
obsolete sucrose catabolic process via 3’-ketosucrose label “obsolete sucrose catabolic process via 3’-ketosucrose”
obsolete sucrose catabolic process via 3’-ketosucrose term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete sucrose catabolic process via 3’-ketosucrose deprecated true
obsolete sucrose catabolic process via 3’-ketosucrose comment “This term was obsoleted because it represents a specific pathway out of scope for GO.”
obsolete sucrose catabolic process via 3’-ketosucrose definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of sucrose, which proceeds via the conversion of sucrose to 3’-ketosucrose. 3’-ketosucrose is hydrolyzed to 3-ketoglucose and fructose, and the 3-ketoglucose is then be converted to glucose.”
- database_cross_reference “GOC:bf”
- database_cross_reference “MetaCyc:SUCROSEUTIL2-PWY”
- database_cross_reference “GOC:dgf”

obsolete sulfur:ferric ion oxidoreductase activity `http://purl.obolibrary.org/obo/GO_0070226`

Removed

obsolete sulfur:ferric ion oxidoreductase activity database_cross_reference “MetaCyc:SULFFEOXIDO-RXN”
obsolete sulfur:ferric ion oxidoreductase activity label “sulfur:ferric ion oxidoreductase activity”
obsolete sulfur:ferric ion oxidoreductase activity definition “Catalysis of the reaction: a perthiol + 4 Fe3+ + 3 H2O = sulfite + a thiol + 4 Fe2+ + 8 H+.”
- database_cross_reference “MetaCyc:SULFFEOXIDO-RXN”
obsolete sulfur:ferric ion oxidoreductase activity SubClassOf oxidoreductase activity, acting on a sulfur group of donors

Added

obsolete sulfur:ferric ion oxidoreductase activity definition “OBSOLETE. Catalysis of the reaction: S-sulfanylglutathione + 4 Fe3+ + 3 H2O = sulfite + 4 Fe2+ + glutathione + 6 H+.”
- database_cross_reference “GOC:curators”
obsolete sulfur:ferric ion oxidoreductase activity deprecated true
obsolete sulfur:ferric ion oxidoreductase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete sulfur:ferric ion oxidoreductase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31518”^^anyURI
obsolete sulfur:ferric ion oxidoreductase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete sulfur:ferric ion oxidoreductase activity label “obsolete sulfur:ferric ion oxidoreductase activity”

obsolete symbiont-mediated suppression of host defense-related programmed cell death `http://purl.obolibrary.org/obo/GO_0034054`

Removed

obsolete symbiont-mediated suppression of host defense-related programmed cell death database_cross_reference “Reactome:R-HSA-9636569”
- label “Suppression of autophagy”

obsolete syncytium formation `http://purl.obolibrary.org/obo/GO_0006949`

Removed

obsolete syncytium formation definition “The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division.”
- database_cross_reference “ISBN:0198506732”
obsolete syncytium formation label “syncytium formation”
obsolete syncytium formation in_subset goslim_pir
obsolete syncytium formation SubClassOf anatomical structure formation involved in morphogenesis
obsolete syncytium formation SubClassOf cellular process

Added

obsolete syncytium formation consider syncytium formation by cell-cell fusion
obsolete syncytium formation deprecated true
obsolete syncytium formation comment “The reason for obsoletion is that this term was an unnecessary grouping term.”
obsolete syncytium formation term tracker item “https://github.com/geneontology/go-ontology/issues/31270”^^anyURI
obsolete syncytium formation label “obsolete syncytium formation”
obsolete syncytium formation definition “OBSOLETE. The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division.”
- database_cross_reference “ISBN:0198506732”

obsolete tRNA (adenine-N6)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0016430`

Removed

obsolete tRNA (adenine-N6)-methyltransferase activity definition “Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine.”
- database_cross_reference “EC:2.1.1.55”
obsolete tRNA (adenine-N6)-methyltransferase activity exactMatch 16785
obsolete tRNA (adenine-N6)-methyltransferase activity database_cross_reference “EC:2.1.1.55”
obsolete tRNA (adenine-N6)-methyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/30193”^^anyURI
obsolete tRNA (adenine-N6)-methyltransferase activity database_cross_reference “RHEA:16785”
obsolete tRNA (adenine-N6)-methyltransferase activity database_cross_reference “MetaCyc:TRNA-ADENINE-N6–METHYLTRANSFERASE-RXN”
obsolete tRNA (adenine-N6)-methyltransferase activity exactMatch 2.1.1.55
obsolete tRNA (adenine-N6)-methyltransferase activity label “tRNA (adenine-N6)-methyltransferase activity”
obsolete tRNA (adenine-N6)-methyltransferase activity SubClassOf N-methyltransferase activity
obsolete tRNA (adenine-N6)-methyltransferase activity SubClassOf tRNA (adenine) methyltransferase activity

Added

obsolete tRNA (adenine-N6)-methyltransferase activity label “obsolete tRNA (adenine-N6)-methyltransferase activity”
obsolete tRNA (adenine-N6)-methyltransferase activity definition “OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine.”
- database_cross_reference “EC:2.1.1.55”
obsolete tRNA (adenine-N6)-methyltransferase activity deprecated true
obsolete tRNA (adenine-N6)-methyltransferase activity comment “This term was obsoleted because there is no evidence that this reaction exists, see PMID:33658722.”
obsolete tRNA (adenine-N6)-methyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/26109”^^anyURI

obsolete tRNA 2’-O-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0106050`

Removed

obsolete tRNA 2’-O-methyltransferase activity definition “Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing a 2’-O-nucleotide.”
- database_cross_reference “PMID:17242307”
obsolete tRNA 2’-O-methyltransferase activity label “tRNA 2’-O-methyltransferase activity”
obsolete tRNA 2’-O-methyltransferase activity SubClassOf tRNA methyltransferase activity
obsolete tRNA 2’-O-methyltransferase activity SubClassOf RNA 2’-O-methyltransferase activity

Added

obsolete tRNA 2’-O-methyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31519”^^anyURI
obsolete tRNA 2’-O-methyltransferase activity deprecated true
obsolete tRNA 2’-O-methyltransferase activity comment “This term was obsoleted because it is an unnecessray grouping term.”
obsolete tRNA 2’-O-methyltransferase activity label “obsolete tRNA 2’-O-methyltransferase activity”
obsolete tRNA 2’-O-methyltransferase activity consider tRNA (cytidine(32)-2’-O-ribose)-methyltransferase activity
obsolete tRNA 2’-O-methyltransferase activity consider tRNA (guanosine(34)-2’-O-ribose)-methyltransferase activity
obsolete tRNA 2’-O-methyltransferase activity definition “OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing a 2’-O-nucleotide.”
- database_cross_reference “PMID:17242307”

obsolete tRNA 3’-trailer cleavage `http://purl.obolibrary.org/obo/GO_0042779`

Removed

obsolete tRNA 3’-trailer cleavage definition “OBSOLETE. Cleavage of the 3’-end of the pre-tRNA as part of the process of generating the mature 3’-end of the tRNA; may involve endonucleolytic or exonucleolytic cleavage, or both.”
- database_cross_reference “GOC:go_curators”

Added

obsolete tRNA 3’-trailer cleavage definition “OBSOLETE. Cleavage of the 3’-end of the pre-tRNA as part of the process of generating the mature 3’-end of the tRNA; may involve endonucleolytic or exonucleolytic cleavage, or both.”
- database_cross_reference “GOC:curators”

obsolete tRNA sulfurtransferase `http://purl.obolibrary.org/obo/GO_0009023`

Removed

obsolete tRNA sulfurtransferase definition “OBSOLETE. Catalysis of the reaction: L-cysteine + activated-tRNA = L-serine + tRNA containing a thionucleotide.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “EC:2.8.1.4”

Added

obsolete tRNA sulfurtransferase definition “OBSOLETE. Catalysis of the reaction: L-cysteine + activated-tRNA = L-serine + tRNA containing a thionucleotide.”
- database_cross_reference “GOC:curators”
- database_cross_reference “EC:2.8.1.4”

obsolete taurine biosynthetic process from L-cysteine `http://purl.obolibrary.org/obo/GO_0019452`

Removed

obsolete taurine biosynthetic process from L-cysteine database_cross_reference “MetaCyc:PWY-7850”
obsolete taurine biosynthetic process from L-cysteine narrowMatch PWY-8359
obsolete taurine biosynthetic process from L-cysteine definition “The chemical reactions and pathways resulting in the formation of taurine (2-aminoethanesulfonic acid) from L-cysteine.”
- database_cross_reference “GOC:go_curators”
obsolete taurine biosynthetic process from L-cysteine narrowMatch PWY-5331
obsolete taurine biosynthetic process from L-cysteine database_cross_reference “MetaCyc:PWY-5331”
obsolete taurine biosynthetic process from L-cysteine label “taurine biosynthetic process from L-cysteine”
obsolete taurine biosynthetic process from L-cysteine database_cross_reference “MetaCyc:PWY-8359”
obsolete taurine biosynthetic process from L-cysteine narrowMatch PWY-7850
obsolete taurine biosynthetic process from L-cysteine SubClassOf obsolete L-cysteine metabolic process
obsolete taurine biosynthetic process from L-cysteine SubClassOf taurine biosynthetic process

Added

obsolete taurine biosynthetic process from L-cysteine comment “This term was obsoleted because it is too specific and is outside the scope of GO.”
obsolete taurine biosynthetic process from L-cysteine definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of taurine (2-aminoethanesulfonic acid) from L-cysteine.”
- database_cross_reference “GOC:curators”
obsolete taurine biosynthetic process from L-cysteine label “obsolete taurine biosynthetic process from L-cysteine”
obsolete taurine biosynthetic process from L-cysteine term replaced by taurine biosynthetic process
obsolete taurine biosynthetic process from L-cysteine deprecated true

obsolete tellurium sensitivity/resistance `http://purl.obolibrary.org/obo/GO_0019873`

Removed

obsolete tellurium sensitivity/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete tellurium sensitivity/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete telomere binding `http://purl.obolibrary.org/obo/GO_0007003`

Removed

obsolete telomere binding definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete telomere binding definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete terminal O-glycosylation `http://purl.obolibrary.org/obo/GO_0006495`

Removed

obsolete terminal O-glycosylation definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:jsg”

Added

obsolete terminal O-glycosylation definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:jsg”

obsolete testosterone dehydrogenase [NAD(P)+] activity `http://purl.obolibrary.org/obo/GO_0030283`

Removed

obsolete testosterone dehydrogenase [NAD(P)+] activity database_cross_reference “Reactome:R-HSA-193064”
- label “HSD17B3-like proteins reducde ANDST to TEST”

obsolete thioredoxin reduction `http://purl.obolibrary.org/obo/GO_0042964`

Removed

obsolete thioredoxin reduction definition “OBSOLETE. The chemical reactions and pathways resulting in the reduction of thioredoxin, a small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase.”
- database_cross_reference “GOC:go_curators”

Added

obsolete thioredoxin reduction definition “OBSOLETE. The chemical reactions and pathways resulting in the reduction of thioredoxin, a small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase.”
- database_cross_reference “GOC:curators”

obsolete thylakoid (sensu Bacteria) `http://purl.obolibrary.org/obo/GO_0009580`

Removed

obsolete thylakoid (sensu Bacteria) definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete thylakoid (sensu Bacteria) definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete toxin susceptibility/resistance `http://purl.obolibrary.org/obo/GO_0017142`

Removed

obsolete toxin susceptibility/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete toxin susceptibility/resistance definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete transmembrane receptor protein serine/threonine kinase signaling protein activity `http://purl.obolibrary.org/obo/GO_0005071`

Removed

obsolete transmembrane receptor protein serine/threonine kinase signaling protein activity definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete transmembrane receptor protein serine/threonine kinase signaling protein activity definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete transmembrane receptor protein tyrosine kinase signaling protein activity `http://purl.obolibrary.org/obo/GO_0005066`

Removed

obsolete transmembrane receptor protein tyrosine kinase signaling protein activity definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete transmembrane receptor protein tyrosine kinase signaling protein activity definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete trioxoheptanoate hydrolase activity `http://purl.obolibrary.org/obo/GO_0018772`

Removed

obsolete trioxoheptanoate hydrolase activity definition “Catalysis of the reaction: 2,4,6-trioxoheptanoate + H2O = acetylpyruvate + acetate.”
- database_cross_reference “UM-BBD_reactionID:r0094”
- database_cross_reference “MetaCyc:R306-RXN”
obsolete trioxoheptanoate hydrolase activity label “trioxoheptanoate hydrolase activity”
obsolete trioxoheptanoate hydrolase activity database_cross_reference “UM-BBD_reactionID:r0094”
obsolete trioxoheptanoate hydrolase activity database_cross_reference “MetaCyc:R306-RXN”
obsolete trioxoheptanoate hydrolase activity SubClassOf hydrolase activity, acting on carbon-carbon bonds, in ketonic substances

Added

obsolete trioxoheptanoate hydrolase activity label “obsolete trioxoheptanoate hydrolase activity”
obsolete trioxoheptanoate hydrolase activity definition “OBSOLETE. Catalysis of the reaction: 2,4,6-trioxoheptanoate + H2O = acetylpyruvate + acetate.”
- database_cross_reference “GOC:curators”
obsolete trioxoheptanoate hydrolase activity deprecated true
obsolete trioxoheptanoate hydrolase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete trioxoheptanoate hydrolase activity comment “This term was obsoleted because it represents a specific substrate.”

obsolete tumor suppressor `http://purl.obolibrary.org/obo/GO_0008181`

Removed

obsolete tumor suppressor definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete tumor suppressor definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete tyrosine catabolic process to phosphoenolpyruvate `http://purl.obolibrary.org/obo/GO_0019446`

Removed

obsolete tyrosine catabolic process to phosphoenolpyruvate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including phosphoenolpyruvate.”
- database_cross_reference “GOC:go_curators”

Added

obsolete tyrosine catabolic process to phosphoenolpyruvate definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including phosphoenolpyruvate.”
- database_cross_reference “GOC:curators”

obsolete ubiquitin `http://purl.obolibrary.org/obo/GO_0005551`

Removed

obsolete ubiquitin definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete ubiquitin definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete ubiquitin-dependent SMAD protein catabolic process `http://purl.obolibrary.org/obo/GO_0030579`

Removed

obsolete ubiquitin-dependent SMAD protein catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome.”
- database_cross_reference “GOC:go_curators”

Added

obsolete ubiquitin-dependent SMAD protein catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome.”
- database_cross_reference “GOC:curators”

obsolete vacuolar assembly `http://purl.obolibrary.org/obo/GO_0005479`

Removed

obsolete vacuolar assembly definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete vacuolar assembly definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete vacuolar hydrogen-transporting ATPase `http://purl.obolibrary.org/obo/GO_0000219`

Removed

obsolete vacuolar hydrogen-transporting ATPase definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete vacuolar hydrogen-transporting ATPase definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete vesicle fusion `http://purl.obolibrary.org/obo/GO_0005481`

Removed

obsolete vesicle fusion definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete vesicle fusion definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete vesicle targeting `http://purl.obolibrary.org/obo/GO_0005482`

Removed

obsolete vesicle targeting definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete vesicle targeting definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete vesicle transport `http://purl.obolibrary.org/obo/GO_0005480`

Removed

obsolete vesicle transport definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete vesicle transport definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete vesicle transport `http://purl.obolibrary.org/obo/GO_0006905`

Removed

obsolete vesicle transport definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete vesicle transport definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete viral replication `http://purl.obolibrary.org/obo/GO_0008166`

Removed

obsolete viral replication definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete viral replication definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete virulence `http://purl.obolibrary.org/obo/GO_0009406`

Removed

obsolete virulence definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:go_curators”

Added

obsolete virulence definition “OBSOLETE. (Was not defined before being made obsolete).”
- database_cross_reference “GOC:curators”

obsolete virus-mediated perturbation of host defense response `http://purl.obolibrary.org/obo/GO_0019049`

Removed

obsolete virus-mediated perturbation of host defense response database_cross_reference “Reactome:R-HSA-169131”
- label “Inhibition of PKR”
obsolete virus-mediated perturbation of host defense response database_cross_reference “Reactome:R-HSA-164938”
- label “Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters”
obsolete virus-mediated perturbation of host defense response database_cross_reference “Reactome:R-HSA-168305”
- label “Inhibition of Interferon Synthesis”
obsolete virus-mediated perturbation of host defense response database_cross_reference “Reactome:R-HSA-164944”
- label “Nef and signal transduction”

obsolete water-soluble vitamin metabolic process `http://purl.obolibrary.org/obo/GO_0006767`

Removed

obsolete water-soluble vitamin metabolic process database_cross_reference “Reactome:R-HSA-196849”
- label “Metabolism of water-soluble vitamins and cofactors”

obsolete zeaxanthin 2,2’-beta-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0102465`

Removed

obsolete zeaxanthin 2,2’-beta-hydroxylase activity label “zeaxanthin 2,2’-beta-hydroxylase activity”
obsolete zeaxanthin 2,2’-beta-hydroxylase activity definition “Catalysis of the reaction: zeaxanthin + 2 NADH + 2 H+ + 2 O2 = nostoxanthin + 2 NAD + 2 H2O.”
- database_cross_reference “GOC:pz”
obsolete zeaxanthin 2,2’-beta-hydroxylase activity database_cross_reference “MetaCyc:RXN-14018”
obsolete zeaxanthin 2,2’-beta-hydroxylase activity SubClassOf oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

Added

obsolete zeaxanthin 2,2’-beta-hydroxylase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31581”^^anyURI
obsolete zeaxanthin 2,2’-beta-hydroxylase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete zeaxanthin 2,2’-beta-hydroxylase activity deprecated true
obsolete zeaxanthin 2,2’-beta-hydroxylase activity definition “OBSOLETE. Catalysis of the reaction: zeaxanthin + 2 NADH + 2 H+ + 2 O2 = nostoxanthin + 2 NAD + 2 H2O.”
- database_cross_reference “GOC:pz”
obsolete zeaxanthin 2,2’-beta-hydroxylase activity label “obsolete zeaxanthin 2,2’-beta-hydroxylase activity”

ocellus photoreceptor cell differentiation `http://purl.obolibrary.org/obo/GO_0042705`

Removed

ocellus photoreceptor cell differentiation definition “The process in which a relatively unspecialized cell acquires specialized features of a photoreceptor cell found in the ocellus.”
- database_cross_reference “GOC:go_curators”

Added

ocellus photoreceptor cell differentiation definition “The process in which a relatively unspecialized cell acquires specialized features of a photoreceptor cell found in the ocellus.”
- database_cross_reference “GOC:curators”

octanol metabolic process `http://purl.obolibrary.org/obo/GO_0006070`

Removed

octanol metabolic process definition “The chemical reactions and pathways involving octanol, the 8-carbon alcohol with the formula C8H17OH.”
- database_cross_reference “GOC:go_curators”

Added

octanol metabolic process definition “The chemical reactions and pathways involving octanol, the 8-carbon alcohol with the formula C8H17OH.”
- database_cross_reference “GOC:curators”

octopamine loading into synaptic vesicle `http://purl.obolibrary.org/obo/GO_0160312`

Added

octopamine loading into synaptic vesicle label “octopamine loading into synaptic vesicle”
octopamine loading into synaptic vesicle has_obo_namespace “biological_process”
octopamine loading into synaptic vesicle definition “The active transport of octopamine neurotransmitters into a synaptic vesicle.”
- database_cross_reference “PMID:9870940”
- database_cross_reference “PMID:15849736”
octopamine loading into synaptic vesicle id “GO:0160312”
octopamine loading into synaptic vesicle term tracker item “https://github.com/geneontology/go-ontology/issues/31143”^^anyURI
octopamine loading into synaptic vesicle created by “rynl”
octopamine loading into synaptic vesicle creation date “2025-12-02T23:21:33Z”
Class: octopamine loading into synaptic vesicle
octopamine loading into synaptic vesicle SubClassOf octopamine transport
octopamine loading into synaptic vesicle SubClassOf aminergic neurotransmitter loading into synaptic vesicle

oenocyte differentiation `http://purl.obolibrary.org/obo/GO_0001742`

Removed

oenocyte differentiation definition “The process in which a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments.”
- database_cross_reference “GOC:go_curators”

Added

oenocyte differentiation definition “The process in which a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments.”
- database_cross_reference “GOC:curators”

oligopeptide export from mitochondrion `http://purl.obolibrary.org/obo/GO_0090374`

Added

oligopeptide export from mitochondrion SubClassOf intercellular transport

oligopeptide transmembrane transport `http://purl.obolibrary.org/obo/GO_0035672`

Added

oligopeptide transmembrane transport database_cross_reference “Reactome:R-HSA-9959399”
- label “SLC-mediated transport of oligopeptides”

omega peptidase activity `http://purl.obolibrary.org/obo/GO_0008242`

Added

omega peptidase activity database_cross_reference “Reactome:R-HSA-5696365”
- label “ASRGL1 hydrolyses aspartame to L-Asp, L-Phe, MeOH”

omega-hydroxyceramide transacylase activity `http://purl.obolibrary.org/obo/GO_0106341`

Added

omega-hydroxyceramide transacylase activity narrowMatch 78119
omega-hydroxyceramide transacylase activity database_cross_reference “RHEA:65692”
omega-hydroxyceramide transacylase activity database_cross_reference “RHEA:78119”
omega-hydroxyceramide transacylase activity narrowMatch 78115
omega-hydroxyceramide transacylase activity narrowMatch 65692
omega-hydroxyceramide transacylase activity database_cross_reference “RHEA:78115”

oocyte development `http://purl.obolibrary.org/obo/GO_0048599`

Removed

oocyte development definition “The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.”
- database_cross_reference “GOC:go_curators”

Added

oocyte development definition “The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.”
- database_cross_reference “GOC:curators”

oocyte differentiation `http://purl.obolibrary.org/obo/GO_0009994`

Removed

oocyte differentiation definition “The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_sensu”

Added

oocyte differentiation definition “The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_sensu”

oocyte fate commitment `http://purl.obolibrary.org/obo/GO_0048600`

Removed

oocyte fate commitment definition “The process in which the developmental fate of a cell becomes restricted such that it will develop into an oocyte.”
- database_cross_reference “GOC:go_curators”

Added

oocyte fate commitment definition “The process in which the developmental fate of a cell becomes restricted such that it will develop into an oocyte.”
- database_cross_reference “GOC:curators”

oocyte fate determination `http://purl.obolibrary.org/obo/GO_0030716`

Removed

oocyte fate determination definition “The process in which a cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed.”
- database_cross_reference “GOC:go_curators”

Added

oocyte fate determination definition “The process in which a cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed.”
- database_cross_reference “GOC:curators”

oocyte morphogenesis `http://purl.obolibrary.org/obo/GO_0048601`

Removed

oocyte morphogenesis definition “The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte.”
- database_cross_reference “GOC:go_curators”

Added

oocyte morphogenesis definition “The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte.”
- database_cross_reference “GOC:curators”

organelle `http://purl.obolibrary.org/obo/GO_0043226`

Removed

organelle definition “Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.”
- database_cross_reference “GOC:go_curators”

Added

organelle definition “Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.”
- database_cross_reference “GOC:curators”

organelle membrane `http://purl.obolibrary.org/obo/GO_0031090`

Added

organelle membrane in_subset gocheck_do_not_annotate
organelle membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31446”^^anyURI

organic anion transport `http://purl.obolibrary.org/obo/GO_0015711`

Added

organic anion transport database_cross_reference “Reactome:R-HSA-9955298”
- label “SLC-mediated transport of organic anions”

ornithine biosynthetic process `http://purl.obolibrary.org/obo/GO_0006592`

Added

ornithine biosynthetic process narrowMatch PWY-6922
ornithine biosynthetic process database_cross_reference “MetaCyc:GLUTORN-PWY”
ornithine biosynthetic process narrowMatch GLUTORN-PWY
ornithine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31510”^^anyURI
ornithine biosynthetic process database_cross_reference “MetaCyc:PWY-6922”

ornithine carbamoyltransferase activity `http://purl.obolibrary.org/obo/GO_0004585`

Added

ornithine carbamoyltransferase activity database_cross_reference “Reactome:R-HSA-9956527”
- label “OTC variants don’t synthesize L-citrulline”

ornithine decarboxylase activator activity `http://purl.obolibrary.org/obo/GO_0042978`

Added

ornithine decarboxylase activator activity database_cross_reference “Reactome:R-HSA-9955574”
- label “ODC dimerizes”

ornithine decarboxylase inhibitor activity `http://purl.obolibrary.org/obo/GO_0008073`

Added

ornithine decarboxylase inhibitor activity database_cross_reference “Reactome:R-HSA-350567”
- label “Antizyme OAZ binds to Ornithine decarboxylase”

ornithine lipid biosynthetic process `http://purl.obolibrary.org/obo/GO_0140371`

Added

ornithine lipid biosynthetic process database_cross_reference “MetaCyc:PWY-6818”
ornithine lipid biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31510”^^anyURI

ornithine transmembrane import into vacuole `http://purl.obolibrary.org/obo/GO_0090455`

Added

ornithine transmembrane import into vacuole SubClassOf intercellular transport

otic placode formation `http://purl.obolibrary.org/obo/GO_0043049`

Removed

otic placode formation definition “The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:12668634”

Added

otic placode formation definition “The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:12668634”

outer membrane `http://purl.obolibrary.org/obo/GO_0019867`

Removed

outer membrane definition “The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.”
- database_cross_reference “GOC:go_curators”

Added

outer membrane definition “The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.”
- database_cross_reference “GOC:curators”

ovarian nurse cell to oocyte transport `http://purl.obolibrary.org/obo/GO_0007300`

Removed

ovarian nurse cell to oocyte transport SubClassOf transport

Added

ovarian nurse cell to oocyte transport SubClassOf intercellular transport

oxalate-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0050203`

Removed

oxalate-CoA ligase activity SubClassOf acid-thiol ligase activity

oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity `http://purl.obolibrary.org/obo/GO_0000703`

Removed

oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity has_exact_synonym “oxidized pyrimidine base lesion DNA N-glycosylase activity”
- database_cross_reference “GOC:go_curators”

Added

oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity has_exact_synonym “oxidized pyrimidine base lesion DNA N-glycosylase activity”
- database_cross_reference “GOC:curators”

oxidoreductase activity `http://purl.obolibrary.org/obo/GO_0016491`

Removed

oxidoreductase activity database_cross_reference “Reactome:R-HSA-209921”
- label “Monoiodinated tyrosine can be deiodinated”
oxidoreductase activity database_cross_reference “Reactome:R-HSA-209960”
- label “Diiodinated tyrosine can be deiodinated”
oxidoreductase activity database_cross_reference “Reactome:R-HSA-8878581”
- label “TYRP1 oxidises DHICA to IQCA”
oxidoreductase activity database_cross_reference “Reactome:R-HSA-5662660”
- label “Dopachrome is transformed to DHICA by DCT”

oxidoreductase activity, acting on a heme group of donors `http://purl.obolibrary.org/obo/GO_0016675`

Removed

oxidoreductase activity, acting on a heme group of donors database_cross_reference “Reactome:R-HSA-5340226”
- label “CYGB dioxygenates NO”

oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor `http://purl.obolibrary.org/obo/GO_0016671`

Added

oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor database_cross_reference “Reactome:R-HSA-9035484”
- label “MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPST”

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen `http://purl.obolibrary.org/obo/GO_0016705`

Added

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen database_cross_reference “Reactome:R-HSA-5333612”
- label “MeSebGalNac is oxidatively cleaved to MeSeO2H and 2-acetamidoglucal”

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen `http://purl.obolibrary.org/obo/GO_0016712`

Removed

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen database_cross_reference “Reactome:R-HSA-194678”
- label “CYP51A1 demethylates LNSOL”

Added

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen database_cross_reference “Reactome:R-HSA-194678”
- label “CYP51A1 demethylates LAN”

oxidoreductase activity, acting on the CH-CH group of donors `http://purl.obolibrary.org/obo/GO_0016627`

Removed

oxidoreductase activity, acting on the CH-CH group of donors database_cross_reference “Reactome:R-HSA-2995334”
- label “COX15 transforms heme O to heme A”

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor `http://purl.obolibrary.org/obo/GO_0016628`

Removed

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor database_cross_reference “Reactome:R-HSA-4419979”
- label “SRD5A3 reduces pPNOL to DCHOL”

oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor `http://purl.obolibrary.org/obo/GO_0016649`

Added

oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor database_cross_reference “Reactome:R-HSA-70670”
- label “PRODH oxidises L-Pro to 1PYR-5COOH”

oxygen evolving activity `http://purl.obolibrary.org/obo/GO_0010242`

Added

oxygen evolving activity database_cross_reference “RHEA:30247”
oxygen evolving activity narrowMatch 30247

pH elevation `http://purl.obolibrary.org/obo/GO_0045852`

Removed

pH elevation definition “Any process that increases the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion.”
- database_cross_reference “GOC:go_curators”

Added

pH elevation definition “Any process that increases the internal pH of an organism, part of an organism or a cell, corresponding to a decrease in hydrogen ion concentration.”
- database_cross_reference “GOC:curators”

pH reduction `http://purl.obolibrary.org/obo/GO_0045851`

Removed

pH reduction definition “Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion.”
- database_cross_reference “GOC:go_curators”

Added

pH reduction definition “Any process that reduces the internal pH of an organism, part of an organism or a cell, corresponding to an increase in hydrogen ion concentration.”
- database_cross_reference “GOC:curators”

palmitoyl-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0090433`

Removed

palmitoyl-CoA ligase activity database_cross_reference “Reactome:R-HSA-434382”
- label “ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell”

Added

palmitoyl-CoA ligase activity database_cross_reference “Reactome:R-HSA-434382”
- label “ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A”

para-aminobenzoic acid metabolic process `http://purl.obolibrary.org/obo/GO_0046482`

Removed

para-aminobenzoic acid metabolic process definition “The chemical reactions and pathways involving para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins.”
- database_cross_reference “PMID:11377864”
- database_cross_reference “PMID:11960743”
- database_cross_reference “ISBN:0198506732”

Added

para-aminobenzoic acid metabolic process definition “The chemical reactions and pathways involving para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins.”
- database_cross_reference “PMID:11960743”

paraxial mesoderm morphogenesis `http://purl.obolibrary.org/obo/GO_0048340`

Removed

paraxial mesoderm morphogenesis definition “The process in which the anatomical structures of the paraxial mesoderm are generated and organized.”
- database_cross_reference “GOC:go_curators”

Added

paraxial mesoderm morphogenesis definition “The process in which the anatomical structures of the paraxial mesoderm are generated and organized.”
- database_cross_reference “GOC:curators”

paternal behavior `http://purl.obolibrary.org/obo/GO_0042712`

Removed

paternal behavior definition “Male behaviors associated with the care and rearing offspring.”
- database_cross_reference “GOC:go_curators”

Added

paternal behavior definition “Male behaviors associated with the care and rearing offspring.”
- database_cross_reference “GOC:curators”

pattern recognition receptor complex `http://purl.obolibrary.org/obo/GO_0140389`

Added

pattern recognition receptor complex has_exact_synonym “PAMP receptor complex”
pattern recognition receptor complex definition “A signaling receptor complex that combines with a pathogen-associated molecular pattern (PAMP), a structure conserved among pathogenic organisms, to initiate an innate immune response.”
- database_cross_reference “PMID:22654057”
- database_cross_reference “PMID:28302675”
- database_cross_reference “PMID:41719893”
pattern recognition receptor complex created by “pg”
pattern recognition receptor complex creation date “2026-02-27T15:46:56Z”
pattern recognition receptor complex id “GO:0140389”
pattern recognition receptor complex label “pattern recognition receptor complex”
pattern recognition receptor complex has_obo_namespace “cellular_component”
pattern recognition receptor complex term tracker item “https://github.com/geneontology/go-ontology/issues/31605”^^anyURI
Class: pattern recognition receptor complex
pattern recognition receptor complex SubClassOf signaling receptor complex

pattern specification process `http://purl.obolibrary.org/obo/GO_0007389`

Removed

pattern specification process definition “Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.”
- database_cross_reference “GOC:isa_complete”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0521436125”

Added

pattern specification process definition “Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:isa_complete”
- database_cross_reference “ISBN:0521436125”

pectin biosynthetic process `http://purl.obolibrary.org/obo/GO_0045489`

Removed

pectin biosynthetic process definition “The chemical reactions and pathways resulting in the formation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:11931668”

Added

pectin biosynthetic process definition “The chemical reactions and pathways resulting in the formation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:11931668”

pectin catabolic process `http://purl.obolibrary.org/obo/GO_0045490`

Removed

pectin catabolic process definition “The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:11931668”

Added

pectin catabolic process definition “The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:11931668”

pentachlorophenol catabolic process `http://purl.obolibrary.org/obo/GO_0019338`

Removed

pentachlorophenol catabolic process definition “The chemical reactions and pathways resulting in the breakdown of pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms.”
- database_cross_reference “GOC:go_curators”

Added

pentachlorophenol catabolic process definition “The chemical reactions and pathways resulting in the breakdown of pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms.”
- database_cross_reference “GOC:curators”

peptidase activity `http://purl.obolibrary.org/obo/GO_0008233`

Added

peptidase activity database_cross_reference “Reactome:R-HSA-9935547”
- label “Lysosomal degradation of ubiqutinated CDH1”

peptide alpha-N-propionyltransferase activity `http://purl.obolibrary.org/obo/GO_0061607`

Removed

peptide alpha-N-propionyltransferase activity SubClassOf part of some N-terminal protein amino acid propionylation

peptide dopaminyltransferase activity `http://purl.obolibrary.org/obo/GO_0120296`

Removed

peptide dopaminyltransferase activity definition “Catalysis of the reaction: dopamine + L-glutaminyl-[protein] = 5-dopaminyl-L-glutamyl-[protein] + NH4(+).”
- database_cross_reference “PMID:22858378”
- database_cross_reference “PMID:32273471”
- database_cross_reference “GOC:sp”

Added

peptide dopaminyltransferase activity definition “Catalysis of the reaction: dopamine + L-glutaminyl-[protein] = 5-dopaminyl-L-glutamyl-[protein] + NH4+.”
- database_cross_reference “PMID:22858378”
- database_cross_reference “PMID:32273471”
- database_cross_reference “GOC:sp”

peptide glutaryltransferase activity `http://purl.obolibrary.org/obo/GO_0106228`

Added

peptide glutaryltransferase activity database_cross_reference “Reactome:R-HSA-9858590”
- label “DLST transfers glutaryl to CoA”

peptide metabolic process `http://purl.obolibrary.org/obo/GO_0006518`

Removed

peptide metabolic process definition “The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.”
- database_cross_reference “GOC:go_curators”

Added

peptide metabolic process definition “The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.”
- database_cross_reference “GOC:curators”

peptide noradrenalinyltransferase activity `http://purl.obolibrary.org/obo/GO_0120298`

Removed

peptide noradrenalinyltransferase activity definition “Catalysis of the reaction: (R)-noradrenaline + L-glutaminyl-[protein] = 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+).”
- database_cross_reference “PMID:22858378”
- database_cross_reference “GOC:sp”

Added

peptide noradrenalinyltransferase activity definition “Catalysis of the reaction: (R)-noradrenaline + L-glutaminyl-[protein] = 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4+.”
- database_cross_reference “PMID:22858378”
- database_cross_reference “GOC:sp”

peptide serotonyltransferase activity `http://purl.obolibrary.org/obo/GO_0120294`

Removed

peptide serotonyltransferase activity definition “Catalysis of the reaction: L-glutaminyl-[protein] + serotonin = 5-serotonyl-L-glutamyl-[protein] + NH4(+).”
- database_cross_reference “PMID:14697203”
- database_cross_reference “GOC:sp”

Added

peptide serotonyltransferase activity definition “Catalysis of the reaction: L-glutaminyl-[protein] + serotonin = 5-serotonyl-L-glutamyl-[protein] + NH4+.”
- database_cross_reference “PMID:14697203”
- database_cross_reference “GOC:sp”

peptide-O-fucosyltransferase activity `http://purl.obolibrary.org/obo/GO_0046922`

Removed

peptide-O-fucosyltransferase activity SubClassOf part of some protein O-linked glycosylation via fucose

peptidoglycan binding `http://purl.obolibrary.org/obo/GO_0042834`

Removed

peptidoglycan binding definition “Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.”
- database_cross_reference “PMID:14698226”
- database_cross_reference “GOC:go_curators”

Added

peptidoglycan binding definition “Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.”
- database_cross_reference “PMID:14698226”
- database_cross_reference “GOC:curators”

peptidoglycan glycosyltransferase activity `http://purl.obolibrary.org/obo/GO_0008955`

Added

peptidoglycan glycosyltransferase activity database_cross_reference “Reactome:R-HSA-9911463”
- label “MrcB elongates peptidoglycan”

peptidoglycan-based cell wall biogenesis `http://purl.obolibrary.org/obo/GO_0009273`

Removed

peptidoglycan-based cell wall biogenesis definition “The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli.”
- database_cross_reference “GOC:go_curators”

Added

peptidoglycan-based cell wall biogenesis definition “The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli.”
- database_cross_reference “GOC:curators”

peptidyl-alanine modification `http://purl.obolibrary.org/obo/GO_0018194`

Removed

peptidyl-alanine modification definition “The modification of peptidyl-alanine.”
- database_cross_reference “GOC:go_curators”

Added

peptidyl-alanine modification definition “The modification of peptidyl-alanine.”
- database_cross_reference “GOC:curators”

peptidyl-amino acid modification `http://purl.obolibrary.org/obo/GO_0018193`

Removed

peptidyl-amino acid modification in_subset goslim_yeast

peptidyl-arginine 3-dioxygenase activity `http://purl.obolibrary.org/obo/GO_0106157`

Added

peptidyl-arginine 3-dioxygenase activity narrowMatch 57164
peptidyl-arginine 3-dioxygenase activity narrowMatch 57160
peptidyl-arginine 3-dioxygenase activity narrowMatch 41556
peptidyl-arginine 3-dioxygenase activity database_cross_reference “RHEA:57160”
peptidyl-arginine 3-dioxygenase activity database_cross_reference “RHEA:41556”
peptidyl-arginine 3-dioxygenase activity database_cross_reference “RHEA:57164”

peptidyl-arginine modification `http://purl.obolibrary.org/obo/GO_0018195`

Removed

peptidyl-arginine modification definition “The modification of peptidyl-arginine.”
- database_cross_reference “GOC:go_curators”

Added

peptidyl-arginine modification definition “The modification of peptidyl-arginine.”
- database_cross_reference “GOC:curators”

peptidyl-aspartic acid 3-dioxygenase activity `http://purl.obolibrary.org/obo/GO_0062101`

Added

peptidyl-cysteine modification `http://purl.obolibrary.org/obo/GO_0018198`

Removed

peptidyl-cysteine modification definition “The modification of peptidyl-cysteine.”
- database_cross_reference “GOC:go_curators”

Added

peptidyl-cysteine modification definition “The modification of peptidyl-cysteine.”
- database_cross_reference “GOC:curators”

peptidyl-glutamic acid modification `http://purl.obolibrary.org/obo/GO_0018200`

Removed

peptidyl-glutamic acid modification definition “The modification of peptidyl-glutamic acid.”
- database_cross_reference “GOC:go_curators”

Added

peptidyl-glutamic acid modification definition “The modification of peptidyl-glutamic acid.”
- database_cross_reference “GOC:curators”

peptidyl-glutamine modification `http://purl.obolibrary.org/obo/GO_0018199`

Removed

peptidyl-glutamine modification definition “The modification of peptidyl-glutamine.”
- database_cross_reference “GOC:go_curators”

Added

peptidyl-glutamine modification definition “The modification of peptidyl-glutamine.”
- database_cross_reference “GOC:curators”

peptidyl-glycine modification `http://purl.obolibrary.org/obo/GO_0018201`

Removed

peptidyl-glycine modification definition “The modification of peptidyl-glycine.”
- database_cross_reference “GOC:go_curators”

Added

peptidyl-glycine modification definition “The modification of peptidyl-glycine.”
- database_cross_reference “GOC:curators”

peptidyl-histidine dioxygenase activity `http://purl.obolibrary.org/obo/GO_0036139`

Added

peptidyl-histidine dioxygenase activity narrowMatch 54264
peptidyl-histidine dioxygenase activity database_cross_reference “RHEA:54024”
peptidyl-histidine dioxygenase activity narrowMatch 54024
peptidyl-histidine dioxygenase activity database_cross_reference “RHEA:54264”

peptidyl-hypusine biosynthetic process `http://purl.obolibrary.org/obo/GO_0008612`

Added

peptidyl-hypusine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31510”^^anyURI
peptidyl-hypusine biosynthetic process database_cross_reference “MetaCyc:PWY-5905”

peptidyl-isoleucine modification `http://purl.obolibrary.org/obo/GO_0018203`

Removed

peptidyl-isoleucine modification definition “The modification of peptidyl-isoleucine.”
- database_cross_reference “GOC:go_curators”

Added

peptidyl-isoleucine modification definition “The modification of peptidyl-isoleucine.”
- database_cross_reference “GOC:curators”

peptidyl-leucine modification `http://purl.obolibrary.org/obo/GO_0018204`

Removed

peptidyl-leucine modification definition “The modification of peptidyl-leucine.”
- database_cross_reference “GOC:go_curators”

Added

peptidyl-leucine modification definition “The modification of peptidyl-leucine.”
- database_cross_reference “GOC:curators”

peptidyl-lysine modification `http://purl.obolibrary.org/obo/GO_0018205`

Removed

peptidyl-lysine modification definition “The modification of peptidyl-lysine.”
- database_cross_reference “GOC:go_curators”

Added

peptidyl-lysine modification definition “The modification of peptidyl-lysine.”
- database_cross_reference “GOC:curators”

peptidyl-methionine modification `http://purl.obolibrary.org/obo/GO_0018206`

Removed

peptidyl-methionine modification definition “The modification of peptidyl-methionine.”
- database_cross_reference “GOC:go_curators”

Added

peptidyl-methionine modification definition “The modification of peptidyl-methionine.”
- database_cross_reference “GOC:curators”

peptidyl-phenylalanine modification `http://purl.obolibrary.org/obo/GO_0018207`

Removed

peptidyl-phenylalanine modification definition “The modification of peptidyl-phenylalanine.”
- database_cross_reference “GOC:go_curators”

Added

peptidyl-phenylalanine modification definition “The modification of peptidyl-phenylalanine.”
- database_cross_reference “GOC:curators”

peptidyl-proline 4-dioxygenase activity `http://purl.obolibrary.org/obo/GO_0031545`

Added

peptidyl-proline 4-dioxygenase activity database_cross_reference “Reactome:R-HSA-9918779”
- label “Proline hydroxylases hydroxylate Polyprotein”
peptidyl-proline 4-dioxygenase activity database_cross_reference “RHEA:48936”
peptidyl-proline 4-dioxygenase activity narrowMatch 48936

peptidyl-proline modification `http://purl.obolibrary.org/obo/GO_0018208`

Removed

peptidyl-proline modification definition “The modification of peptidyl-proline.”
- database_cross_reference “GOC:go_curators”

Added

peptidyl-proline modification definition “The modification of peptidyl-proline.”
- database_cross_reference “GOC:curators”

peptidyl-serine modification `http://purl.obolibrary.org/obo/GO_0018209`

Removed

peptidyl-serine modification definition “The modification of peptidyl-serine.”
- database_cross_reference “GOC:go_curators”

Added

peptidyl-serine modification definition “The modification of peptidyl-serine.”
- database_cross_reference “GOC:curators”

peptidyl-tRNA hydrolase activity `http://purl.obolibrary.org/obo/GO_0004045`

Added

peptidyl-tRNA hydrolase activity database_cross_reference “Reactome:R-HSA-9937374”
- label “MTRFR:MTRES1:39S ribosomal subunit:mRNA:peptidyl-tRNA:MALSU1:MIEF1:NDUFAB1 dissociates”
peptidyl-tRNA hydrolase activity database_cross_reference “Reactome:R-HSA-9937719”
- label “ICT1 hydrolyzes the peptidyl-tRNA bond of the nascent polypeptide”
peptidyl-tRNA hydrolase activity narrowMatch 81979
peptidyl-tRNA hydrolase activity database_cross_reference “RHEA:81979”

peptidyl-threonine modification `http://purl.obolibrary.org/obo/GO_0018210`

Removed

peptidyl-threonine modification definition “The modification of peptidyl-threonine.”
- database_cross_reference “GOC:go_curators”

Added

peptidyl-threonine modification definition “The modification of peptidyl-threonine.”
- database_cross_reference “GOC:curators”

peptidyl-tyrosine modification `http://purl.obolibrary.org/obo/GO_0018212`

Removed

peptidyl-tyrosine modification definition “The modification of peptidyl-tyrosine.”
- database_cross_reference “GOC:go_curators”

Added

peptidyl-tyrosine modification definition “The modification of peptidyl-tyrosine.”
- database_cross_reference “GOC:curators”

peptidyl-valine modification `http://purl.obolibrary.org/obo/GO_0018213`

Removed

peptidyl-valine modification definition “The modification of peptidyl-valine.”
- database_cross_reference “GOC:go_curators”

Added

peptidyl-valine modification definition “The modification of peptidyl-valine.”
- database_cross_reference “GOC:curators”

peptidyltransferase activity `http://purl.obolibrary.org/obo/GO_0000048`

Removed

peptidyltransferase activity definition “Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2). This reaction is catalyzed by a ribozyme.”
- database_cross_reference “PMID:9242921”
- database_cross_reference “PMID:11433365”

Added

peptidyltransferase activity definition “Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2). This reaction is catalyzed by a ribozyme.”
- database_cross_reference “EC:2.3.2.12”
- database_cross_reference “PMID:9242921”
- database_cross_reference “PMID:11433365”

pericentric heterochromatin formation `http://purl.obolibrary.org/obo/GO_0031508`

Removed

pericentric heterochromatin formation SubClassOf obsolete pericentric heterochromatin organization

perillic acid-CoA ligase (AMP-forming) activity `http://purl.obolibrary.org/obo/GO_0052686`

Removed

perillic acid-CoA ligase (AMP-forming) activity SubClassOf acid-thiol ligase activity

peripheral nervous system development `http://purl.obolibrary.org/obo/GO_0007422`

Removed

peripheral nervous system development definition “The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “UBERON:0000010”

Added

peripheral nervous system development definition “The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.”
- database_cross_reference “GOC:curators”
- database_cross_reference “UBERON:0000010”

periplasmic flagellum `http://purl.obolibrary.org/obo/GO_0055040`

Added

periplasmic flagellum SubClassOf extracellular membraneless organelle

periplasmic side of cell outer membrane `http://purl.obolibrary.org/obo/GO_0031241`

Removed

periplasmic side of cell outer membrane definition “The side (leaflet) of the outer membrane that faces the periplasm of the cell.”
- database_cross_reference “GOC:mtg_sensu”
- database_cross_reference “GOC:mlg”

Added

periplasmic side of cell outer membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
periplasmic side of cell outer membrane definition “The leaflet of a outer cell membrane that faces the periplasm, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:mtg_sensu”
- database_cross_reference “GOC:mlg”

periplasmic side of plasma membrane `http://purl.obolibrary.org/obo/GO_0098567`

Removed

periplasmic side of plasma membrane definition “The side (leaflet) of a plasma membrane that faces the periplasm, and all proteins embedded in it or attached to its surface.”
- database_cross_reference “GOC:dos”

Added

periplasmic side of plasma membrane definition “The leaflet of the plasma membrane that faces the periplasm, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:dos”
periplasmic side of plasma membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI

periplasmic space `http://purl.obolibrary.org/obo/GO_0042597`

Removed

periplasmic space definition “The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:md”

Added

periplasmic space definition “The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:md”
periplasmic space term tracker item “https://github.com/geneontology/go-ontology/issues/31720”^^anyURI
periplasmic space SubClassOf part of some extracellular region

periplastidial membrane `http://purl.obolibrary.org/obo/GO_7770041`

Added

periplastidial membrane id “GO:7770041”
periplastidial membrane has_obo_namespace “cellular_component”
periplastidial membrane has_exact_synonym “PPM”
periplastidial membrane definition “The lipid bilayer that forms the second outermost membrane of complex plastids in organisms that acquired their plastids through secondary endosymbiosis. The periplastidial membrane is evolutionarily derived from the plasma membrane of the engulfed algal endosymbiont and together with the outer envelope membrane of the plastid defines the periplastidial compartment.”
- database_cross_reference “PMID:39383259”
- database_cross_reference “PMID:27179349”
- database_cross_reference “PMID:15937721”
periplastidial membrane label “periplastidial membrane”
periplastidial membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31421”^^anyURI
periplastidial membrane created by “dragon-ai-agent”
periplastidial membrane creation date “2026-01-29T01:11:34Z”
Class: periplastidial membrane
periplastidial membrane SubClassOf plastid membrane

perisynaptic space `http://purl.obolibrary.org/obo/GO_0099544`

Removed

perisynaptic space SubClassOf extracellular region

Added

perisynaptic space term tracker item “https://github.com/geneontology/go-ontology/issues/31720”^^anyURI
perisynaptic space SubClassOf cellular anatomical structure
perisynaptic space SubClassOf part of some extracellular region

perivitelline space `http://purl.obolibrary.org/obo/GO_0098595`

Removed

perivitelline space SubClassOf extracellular region

Added

perivitelline space term tracker item “https://github.com/geneontology/go-ontology/issues/31720”^^anyURI
perivitelline space SubClassOf cellular anatomical structure
perivitelline space SubClassOf part of some extracellular region

peroxidase activity `http://purl.obolibrary.org/obo/GO_0004601`

Removed

peroxidase activity database_cross_reference “Reactome:R-HSA-209925”
- label “DIT and MIT combine to form triiodothyronine”
peroxidase activity database_cross_reference “Reactome:R-HSA-350901”
- label “Iodide is organified”
peroxidase activity database_cross_reference “Reactome:R-HSA-209973”
- label “Tyrosine is diiodinated”
peroxidase activity database_cross_reference “Reactome:R-HSA-209840”
- label “Two DITs combine to form thyroxine”
peroxidase activity database_cross_reference “Reactome:R-HSA-209815”
- label “Tyrosine is monoiodinated”

peroxiredoxin activity `http://purl.obolibrary.org/obo/GO_0051920`

Added

peroxiredoxin activity narrowMatch 62640
peroxiredoxin activity database_cross_reference “RHEA:62640”
peroxiredoxin activity narrowMatch 62624
peroxiredoxin activity database_cross_reference “RHEA:62624”

petal development `http://purl.obolibrary.org/obo/GO_0048441`

Removed

petal development definition “The process whose specific outcome is the progression of the petal over time, from its formation to the mature structure.”
- database_cross_reference “GOC:go_curators”

Added

petal development definition “The process whose specific outcome is the progression of the petal over time, from its formation to the mature structure.”
- database_cross_reference “GOC:curators”

petal morphogenesis `http://purl.obolibrary.org/obo/GO_0048446`

Removed

petal morphogenesis definition “The process in which the anatomical structures of the petal are generated and organized.”
- database_cross_reference “GOC:go_curators”

Added

petal morphogenesis definition “The process in which the anatomical structures of the petal are generated and organized.”
- database_cross_reference “GOC:curators”

phagocytic vesicle `http://purl.obolibrary.org/obo/GO_0045335`

Removed

phagocytic vesicle definition “A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

phagocytic vesicle definition “A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

phagosome acidification `http://purl.obolibrary.org/obo/GO_0090383`

Removed

phagosome acidification definition “Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion.”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:kmv”

Added

phagosome acidification definition “Any process that reduces the pH of the phagosome, corresponding to an increase in hydrogen ion concentration.”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:kmv”

phagosome acidification involved in apoptotic cell clearance `http://purl.obolibrary.org/obo/GO_0090390`

Removed

phagosome acidification involved in apoptotic cell clearance definition “Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion, and occurs as a part of apoptotic cell clearance.”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:kmv”

Added

phagosome acidification involved in apoptotic cell clearance definition “Any process that reduces the pH of the phagosome, corresponding to an increase in hydrogen ion concentration, and occurs as a part of apoptotic cell clearance.”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:kmv”

phagosome reneutralization `http://purl.obolibrary.org/obo/GO_0044655`

Removed

phagosome reneutralization definition “Any process that increases the pH of the phagosome, measured by the concentration of the hydrogen ion, as part of the process of phagosome maturation.”
- database_cross_reference “GOC:rjd”
- database_cross_reference “PMID:22008230”

Added

phagosome reneutralization definition “Any process that increases the pH of the phagosome, corresponding to a decrease in hydrogen ion concentration, as part of the process of phagosome maturation.”
- database_cross_reference “GOC:rjd”
- database_cross_reference “PMID:22008230”

phenol-containing compound catabolic process `http://purl.obolibrary.org/obo/GO_0019336`

Removed

phenol-containing compound catabolic process database_cross_reference “MetaCyc:PHENOLDEG-PWY”

Added

phenol-containing compound catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI

phenylacetate catabolic process `http://purl.obolibrary.org/obo/GO_0010124`

Added

phenylacetate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
phenylacetate catabolic process narrowMatch PWY0-321
phenylacetate catabolic process narrowMatch PWY-1341
phenylacetate catabolic process database_cross_reference “MetaCyc:PWY-1341”

phenylacetate-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0047475`

Removed

phenylacetate-CoA ligase activity SubClassOf acid-thiol ligase activity

phenylalanine 4-monooxygenase activity `http://purl.obolibrary.org/obo/GO_0004505`

Removed

phenylalanine 4-monooxygenase activity SubClassOf part of some obsolete L-tyrosine biosynthetic process, by oxidation of phenylalanine

Added

phenylalanine 4-monooxygenase activity SubClassOf part of some L-tyrosine biosynthetic process

phenylethylamine catabolic process `http://purl.obolibrary.org/obo/GO_0019607`

Added

phenylethylamine catabolic process narrowMatch PHENDEG-PWY
phenylethylamine catabolic process narrowMatch PWY-6534
phenylethylamine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
phenylethylamine catabolic process database_cross_reference “MetaCyc:PWY-6534”

phosphatase activator activity `http://purl.obolibrary.org/obo/GO_0019211`

Added

phosphatase activator activity database_cross_reference “Reactome:R-HSA-6809238”
- label “MTMR7 binds MTMR9”
phosphatase activator activity database_cross_reference “Reactome:R-HSA-6809793”
- label “MTMR2 binds SBF2”
phosphatase activator activity database_cross_reference “Reactome:R-HSA-6809309”
- label “MTMR6 binds MTMR9”
phosphatase activator activity database_cross_reference “Reactome:R-HSA-6809254”
- label “MTMR8 binds MTMR9”
phosphatase activator activity database_cross_reference “Reactome:R-HSA-6809680”
- label “MTMR12 binds MTM1”

phosphatase activity `http://purl.obolibrary.org/obo/GO_0016791`

Added

phosphatase activity database_cross_reference “Reactome:R-HSA-9940993”
- label “PXYLP1 dephosphorylates Xyl moiety”

phosphate ion transmembrane transport `http://purl.obolibrary.org/obo/GO_0035435`

Added

phosphate ion transmembrane transport database_cross_reference “Reactome:R-HSA-427652”
- label “Sodium-coupled phosphate cotransporters”

phosphate transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0005315`

Added

phosphate transmembrane transporter activity database_cross_reference “Reactome:R-HSA-5226964”
- label “ANKH transports PPi from cytosol to extracellular region”

phosphatidate cytidylyltransferase activity `http://purl.obolibrary.org/obo/GO_0004605`

Added

phosphatidate cytidylyltransferase activity narrowMatch 45652
phosphatidate cytidylyltransferase activity narrowMatch 45668
phosphatidate cytidylyltransferase activity database_cross_reference “RHEA:45668”
phosphatidate cytidylyltransferase activity narrowMatch 45664
phosphatidate cytidylyltransferase activity database_cross_reference “RHEA:45664”
phosphatidate cytidylyltransferase activity database_cross_reference “RHEA:45652”

phosphatidate phosphatase activity `http://purl.obolibrary.org/obo/GO_0008195`

Added

phosphatidate phosphatase activity narrowMatch 43296
phosphatidate phosphatase activity narrowMatch 43252
phosphatidate phosphatase activity narrowMatch 43284
phosphatidate phosphatase activity database_cross_reference “RHEA:41255”
phosphatidate phosphatase activity narrowMatch 42860
phosphatidate phosphatase activity database_cross_reference “RHEA:43296”
phosphatidate phosphatase activity database_cross_reference “RHEA:43256”
phosphatidate phosphatase activity database_cross_reference “RHEA:43252”
phosphatidate phosphatase activity database_cross_reference “RHEA:42860”
phosphatidate phosphatase activity database_cross_reference “RHEA:43236”
phosphatidate phosphatase activity narrowMatch 43256
phosphatidate phosphatase activity narrowMatch 41255
phosphatidate phosphatase activity narrowMatch 43236
phosphatidate phosphatase activity database_cross_reference “RHEA:43280”
phosphatidate phosphatase activity database_cross_reference “RHEA:43260”
phosphatidate phosphatase activity narrowMatch 43280
phosphatidate phosphatase activity narrowMatch 43260
phosphatidate phosphatase activity database_cross_reference “RHEA:43284”

phosphatidylcholine binding `http://purl.obolibrary.org/obo/GO_0031210`

Added

phosphatidylcholine binding database_cross_reference “Reactome:R-HSA-8873794”
- label “PCTP binds PC”
phosphatidylcholine binding database_cross_reference “Reactome:R-HSA-8873923”
- label “STARD10 binds LPCAT1 and PC”

phosphatidylcholine intramembrane carrier activity `http://purl.obolibrary.org/obo/GO_0008525`

Removed

phosphatidylcholine intramembrane carrier activity definition “Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.”
- database_cross_reference “GOC:ai”
- database_cross_reference “ISBN:0198506732”
phosphatidylcholine intramembrane carrier activity label “phosphatidylcholine transporter activity”
phosphatidylcholine intramembrane carrier activity SubClassOf obsolete phospholipid transporter activity

Added

phosphatidylcholine intramembrane carrier activity term tracker item “https://github.com/geneontology/go-ontology/issues/10882”^^anyURI
phosphatidylcholine intramembrane carrier activity label “phosphatidylcholine intramembrane carrier activity”
phosphatidylcholine intramembrane carrier activity has_broad_synonym “phosphatidylcholine transporter activity”
phosphatidylcholine intramembrane carrier activity definition “Enables the transport of phosphatidylcholine from a region of a membrane to a different region on the same membrane.”
- database_cross_reference “GOC:ai”
- database_cross_reference “ISBN:0198506732”
phosphatidylcholine intramembrane carrier activity has_broad_synonym “phosphatidylcholine intramembrane transporter activity”
phosphatidylcholine intramembrane carrier activity term tracker item “https://github.com/geneontology/go-ontology/issues/31454”^^anyURI
phosphatidylcholine intramembrane carrier activity SubClassOf intramembrane lipid carrier activity

phosphatidylcholine phospholipase C activity `http://purl.obolibrary.org/obo/GO_0034480`

Added

phosphatidylcholine phospholipase C activity narrowMatch 78947
phosphatidylcholine phospholipase C activity database_cross_reference “RHEA:78947”
phosphatidylcholine phospholipase C activity database_cross_reference “RHEA:45304”
phosphatidylcholine phospholipase C activity narrowMatch 78939
phosphatidylcholine phospholipase C activity narrowMatch 45304
phosphatidylcholine phospholipase C activity database_cross_reference “RHEA:78939”

phosphatidylcholine transfer activity `http://purl.obolibrary.org/obo/GO_0120019`

Removed

phosphatidylcholine transfer activity SubClassOf phosphatidylcholine intramembrane carrier activity

Added

phosphatidylcholine transfer activity database_cross_reference “Reactome:R-HSA-9956308”
- label “STARD7 transports PC from ER membrane to mitochondrial outer membrane”

phosphatidylcholine-retinol O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0047173`

Added

phosphatidylcholine-sterol O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0004607`

Added

phosphatidylethanolamine N-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0004608`

Added

phosphatidylethanolamine binding `http://purl.obolibrary.org/obo/GO_0008429`

Added

phosphatidylethanolamine binding database_cross_reference “Reactome:R-HSA-9842115”
- label “PSAP(195-273) dimer binds PE”

phosphatidylethanolamine floppase activity `http://purl.obolibrary.org/obo/GO_0140341`

Removed

phosphatidylethanolamine floppase activity SubClassOf obsolete phospholipid transporter activity

phosphatidylinositol 5-phosphate metabolic process `http://purl.obolibrary.org/obo/GO_1904562`

Removed

phosphatidylinositol 5-phosphate metabolic process SubClassOf phosphatidylinositol metabolic process

Added

phosphatidylinositol 5-phosphate metabolic process SubClassOf glycerophospholipid metabolic process

phosphatidylinositol binding `http://purl.obolibrary.org/obo/GO_0035091`

Removed

phosphatidylinositol binding definition “Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.”
- database_cross_reference “GOC:bf”
- database_cross_reference “PMID:11395417”
- database_cross_reference “ISBN:0198506732”
phosphatidylinositol binding SubClassOf phospholipid binding

Added

phosphatidylinositol binding definition “Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.”
- database_cross_reference “PMID:11395417”
phosphatidylinositol binding term tracker item “https://github.com/geneontology/go-ontology/issues/27059”^^anyURI
phosphatidylinositol binding SubClassOf anion binding

phosphatidylinositol biosynthetic process `http://purl.obolibrary.org/obo/GO_0006661`

Removed

phosphatidylinositol biosynthetic process SubClassOf glycerophospholipid biosynthetic process

Added

phosphatidylinositol biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/27059”^^anyURI
phosphatidylinositol biosynthetic process SubClassOf biosynthetic process

phosphatidylinositol bisphosphate binding `http://purl.obolibrary.org/obo/GO_1902936`

Added

phosphatidylinositol bisphosphate binding database_cross_reference “Reactome:R-HSA-8870332”
- label “PTPN13:PLEKHA1,2 bind PI(3,4)P2”

phosphatidylinositol catabolic process `http://purl.obolibrary.org/obo/GO_0031161`

Removed

phosphatidylinositol catabolic process SubClassOf glycerophospholipid catabolic process

Added

phosphatidylinositol catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/27059”^^anyURI
phosphatidylinositol catabolic process SubClassOf catabolic process

phosphatidylinositol lysophospholipase A1 activity `http://purl.obolibrary.org/obo/GO_0120561`

Added

phosphatidylinositol metabolic process `http://purl.obolibrary.org/obo/GO_0046488`

Removed

phosphatidylinositol metabolic process SubClassOf glycerophospholipid metabolic process

Added

phosphatidylinositol metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/27059”^^anyURI
phosphatidylinositol metabolic process SubClassOf phosphorus metabolic process

phosphatidylinositol phosphate binding `http://purl.obolibrary.org/obo/GO_1901981`

Removed

phosphatidylinositol phosphate binding SubClassOf phosphatidylinositol binding

Added

phosphatidylinositol phosphate binding SubClassOf phospholipid binding

phosphatidylinositol phosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0046854`

Removed

phosphatidylinositol phosphate biosynthetic process SubClassOf phosphatidylinositol biosynthetic process

Added

phosphatidylinositol phosphate biosynthetic process SubClassOf glycerophospholipid biosynthetic process

phosphatidylinositol transfer activity `http://purl.obolibrary.org/obo/GO_0008526`

Removed

phosphatidylinositol transfer activity SubClassOf phospholipid transfer activity

Added

phosphatidylinositol transfer activity SubClassOf lipid transfer activity

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity `http://purl.obolibrary.org/obo/GO_0016314`

Added

phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity `http://purl.obolibrary.org/obo/GO_0034485`

Added

phosphatidylinositol-3,4-bisphosphate binding `http://purl.obolibrary.org/obo/GO_0043325`

Removed

phosphatidylinositol-3,4-bisphosphate binding definition “Binding to phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3’ and 4’ positions.”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:go_curators”

Added

phosphatidylinositol-3,4-bisphosphate binding definition “Binding to phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3’ and 4’ positions.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:bf”

phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity `http://purl.obolibrary.org/obo/GO_0052629`

Added

phosphatidylinositol-3-phosphate binding `http://purl.obolibrary.org/obo/GO_0032266`

Added

phosphatidylinositol-3-phosphate binding database_cross_reference “Reactome:R-HSA-8870489”
- label “PLEKHA4,(5,6) bind PI3P”

phosphatidylinositol-3-phosphate phosphatase activity `http://purl.obolibrary.org/obo/GO_0004438`

Added

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity `http://purl.obolibrary.org/obo/GO_0004439`

Added

phosphatidylinositol-4-phosphate phosphatase activity `http://purl.obolibrary.org/obo/GO_0043812`

Added

phosphatidylinositol-4-phosphate-cholesterol exchange activity `http://purl.obolibrary.org/obo/GO_0160291`

Removed

phosphatidylinositol-4-phosphate-cholesterol exchange activity definition “Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out). This reaction results in the exchange of cholesterol for phosphatidylinositol-4-phosphate (PI(4)P) between membranes.”
- database_cross_reference “PMID:29596003”
- database_cross_reference “PMID:24209621”
phosphatidylinositol-4-phosphate-cholesterol exchange activity SubClassOf phosphatidylinositol transfer activity

Added

phosphatidylinositol-4-phosphate-cholesterol exchange activity definition “Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out). This reaction results in the exchange of cholesterol for phosphatidylinositol-4-phosphate (PI(4)P) between membranes.”
- database_cross_reference “PMID:29596003”
- database_cross_reference “RHEA:84179”
- database_cross_reference “PMID:24209621”
phosphatidylinositol-4-phosphate-cholesterol exchange activity database_cross_reference “RHEA:84179”
phosphatidylinositol-4-phosphate-cholesterol exchange activity exactMatch 84179
phosphatidylinositol-4-phosphate-cholesterol exchange activity SubClassOf phospholipid transfer activity

phosphatidylinositol-5-phosphate phosphatase activity `http://purl.obolibrary.org/obo/GO_0102091`

Added

phosphatidylserine floppase activity `http://purl.obolibrary.org/obo/GO_0090556`

Removed

phosphatidylserine floppase activity SubClassOf obsolete phospholipid transporter activity

phosphatidylserine lysophospholipase A1 activity `http://purl.obolibrary.org/obo/GO_0120560`

Added

phosphatidylserine-phosphatidylinositol-4-phosphate exchange activity `http://purl.obolibrary.org/obo/GO_0160270`

Removed

phosphatidylserine-phosphatidylinositol-4-phosphate exchange activity SubClassOf phosphatidylinositol transfer activity

phosphodiesterase decapping endonuclease activity `http://purl.obolibrary.org/obo/GO_1990174`

Added

phosphodiesterase decapping endonuclease activity database_cross_reference “Reactome:R-HSA-9935300”
- label “DXO decaps NAD-capped RNA (NAD-RNA)”
phosphodiesterase decapping endonuclease activity database_cross_reference “Reactome:R-HSA-9935319”
- label “DXO decaps incompletely capped RNA (GpppN-RNA)”

phosphogluconate dehydrogenase (decarboxylating) activity `http://purl.obolibrary.org/obo/GO_0004616`

Removed

phosphogluconate dehydrogenase (decarboxylating) activity database_cross_reference “Reactome:R-HSA-71299”
- label “6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+”

Added

phosphogluconate dehydrogenase (decarboxylating) activity database_cross_reference “Reactome:R-HSA-71299”
- label “PGD decarboxylates 6-phospho-D-gluconate”

phosphoglycerate kinase activity `http://purl.obolibrary.org/obo/GO_0004618`

Removed

phosphoglycerate kinase activity database_cross_reference “Reactome:R-HSA-71850”
- label “1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP”

Added

phosphoglycerate kinase activity database_cross_reference “Reactome:R-HSA-71850”
- label “PGK complexes dephosphorylate 1,3BPG”

phosphoglycerate mutase activity `http://purl.obolibrary.org/obo/GO_0004619`

Removed

phosphoglycerate mutase activity database_cross_reference “Reactome:R-HSA-71445”
- label “PGAM dimers (PGAM1,2) isomerise 2PG to 3PG”
phosphoglycerate mutase activity database_cross_reference “Reactome:R-HSA-71654”
- label “3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate”

Added

phosphoglycerate mutase activity database_cross_reference “Reactome:R-HSA-71445”
- label “PGAM dimers isomerise 2PG to 3PG”
phosphoglycerate mutase activity database_cross_reference “Reactome:R-HSA-71654”
- label “PGAM dimers isomerise 3PG to 2PG”

phospholipid scramblase activity `http://purl.obolibrary.org/obo/GO_0017128`

Removed

phospholipid scramblase activity SubClassOf obsolete phospholipid transporter activity

phospholipid transfer activity `http://purl.obolibrary.org/obo/GO_0120014`

Removed

phospholipid transfer activity SubClassOf obsolete phospholipid transporter activity

Added

phospholipid transfer activity SubClassOf part of some phospholipid transport

phospholipid transfer to membrane `http://purl.obolibrary.org/obo/GO_0006649`

Removed

phospholipid transfer to membrane definition “The transfer of a phospholipid from its site of synthesis to the plasma membrane.”
- database_cross_reference “GOC:go_curators”

Added

phospholipid transfer to membrane definition “The transfer of a phospholipid from its site of synthesis to the plasma membrane.”
- database_cross_reference “GOC:curators”

phospholipid-hydroperoxide glutathione peroxidase activity `http://purl.obolibrary.org/obo/GO_0047066`

Added

phospholipid:diacylglycerol acyltransferase activity `http://purl.obolibrary.org/obo/GO_0046027`

Removed

phospholipid:diacylglycerol acyltransferase activity relatedMatch 77739

Added

phospholipid:diacylglycerol acyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31730”^^anyURI

phosphoprotein phosphatase activity `http://purl.obolibrary.org/obo/GO_0004721`

Removed

phosphoprotein phosphatase activity database_cross_reference “Reactome:R-HSA-170158”
- label “Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes”

Added

phosphoprotein phosphatase activity database_cross_reference “Reactome:R-HSA-170158”
- label “CDC25A dephosphorylates CCNA:CDK1”

phosphopyruvate hydratase activity `http://purl.obolibrary.org/obo/GO_0004634`

Removed

phosphopyruvate hydratase activity database_cross_reference “Reactome:R-HSA-71660”
- label “2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O”

Added

phosphopyruvate hydratase activity database_cross_reference “Reactome:R-HSA-71660”
- label “Enolase dimers dehydrates 2PG”

phosphoramidate-hexose phosphotransferase activity `http://purl.obolibrary.org/obo/GO_0047329`

Removed

phosphoramidate-hexose phosphotransferase activity definition “Catalysis of the reaction: hexose + phosphoramidate = hexose 1-phosphate + NH3.”
- database_cross_reference “EC:2.7.1.62”
- database_cross_reference “MetaCyc:2.7.1.62-RXN”

Added

phosphoramidate-hexose phosphotransferase activity definition “Catalysis of the reaction: phosphoramidate + a D-hexose + H+ = alpha-D-hexose 1-phosphate + NH4+.”
- database_cross_reference “RHEA:10972”

phosphorus-oxygen lyase activity `http://purl.obolibrary.org/obo/GO_0016849`

Removed

Added

phosphorus-oxygen lyase activity database_cross_reference “EC:4.6.1.-“
phosphorus-oxygen lyase activity exactMatch 4.6.1.-

phosphotransferase activity, alcohol group as acceptor `http://purl.obolibrary.org/obo/GO_0016773`

Added

phosphotransferase activity, alcohol group as acceptor database_cross_reference “Reactome:R-HSA-9941039”
- label “FAM20B phosphorylates Xyl moiety”

phosphotransferase activity, for other substituted phosphate groups `http://purl.obolibrary.org/obo/GO_0016780`

Added

phosphotransferase activity, for other substituted phosphate groups database_cross_reference “Reactome:R-HSA-9940735”
- label “FKTN transfers RboP to GalNAc-GlcNAc-ManP-DAG1”
phosphotransferase activity, for other substituted phosphate groups database_cross_reference “Reactome:R-HSA-9940756”
- label “FKRP dimer transfers RboP to matriglycan chain”

photoreceptor activity `http://purl.obolibrary.org/obo/GO_0009881`

Removed

photoreceptor activity definition “The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:ai”

Added

photoreceptor activity definition “The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:ai”

photoreceptor cell development `http://purl.obolibrary.org/obo/GO_0042461`

Removed

photoreceptor cell development definition “Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light.”
- database_cross_reference “GOC:go_curators”

Added

photoreceptor cell development definition “Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light.”
- database_cross_reference “GOC:curators”

photorespiration `http://purl.obolibrary.org/obo/GO_0009853`

Added

photorespiration narrowMatch PWY-8363
photorespiration narrowMatch PWY-8362
photorespiration database_cross_reference “MetaCyc:PWY-8363”
photorespiration term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
photorespiration database_cross_reference “MetaCyc:PWY-8362”
photorespiration narrowMatch PWY-181

photosynthesis, light reaction `http://purl.obolibrary.org/obo/GO_0019684`

Added

photosynthesis, light reaction term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
photosynthesis, light reaction database_cross_reference “MetaCyc:PWY2PN3-7”
photosynthesis, light reaction narrowMatch PWY2PN3-7
photosynthesis, light reaction narrowMatch PWY-101

photosystem I assembly `http://purl.obolibrary.org/obo/GO_0048564`

Removed

photosystem I assembly definition “The aggregation, arrangement and bonding together of a set of components to form a photosystem I complex on the thylakoid membrane.”
- database_cross_reference “GOC:go_curators”

Added

photosystem I assembly definition “The aggregation, arrangement and bonding together of a set of components to form a photosystem I complex on the thylakoid membrane.”
- database_cross_reference “GOC:curators”

photosystem I stabilization `http://purl.obolibrary.org/obo/GO_0042550`

Removed

photosystem I stabilization definition “The stabilization of the photosystem I protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis.”
- database_cross_reference “GOC:go_curators”

Added

photosystem I stabilization definition “The stabilization of the photosystem I protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis.”
- database_cross_reference “GOC:curators”

photosystem II stabilization `http://purl.obolibrary.org/obo/GO_0042549`

Removed

photosystem II stabilization definition “The stabilization of the photosystem II protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis.”
- database_cross_reference “GOC:go_curators”

Added

photosystem II stabilization definition “The stabilization of the photosystem II protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis.”
- database_cross_reference “GOC:curators”

phototransduction `http://purl.obolibrary.org/obo/GO_0007602`

Removed

phototransduction definition “The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.”
- database_cross_reference “GOC:go_curators”

Added

phototransduction definition “The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.”
- database_cross_reference “GOC:curators”

phototransduction, UV `http://purl.obolibrary.org/obo/GO_0007604`

Removed

phototransduction, UV definition “The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 400 nanometers.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

phototransduction, UV definition “The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 400 nanometers.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

phototransduction, visible light `http://purl.obolibrary.org/obo/GO_0007603`

Removed

phototransduction, visible light definition “The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

phototransduction, visible light definition “The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

phycoerythrobilin synthase activity `http://purl.obolibrary.org/obo/GO_7770044`

Added

phycoerythrobilin synthase activity definition “Catalysis of the reaction: biliverdin IXalpha + 2 reduced ferredoxin + 4 H+ = (3Z)-phycoerythrobilin + 2 oxidized ferredoxin.”
- database_cross_reference “PMID:18662988”
- database_cross_reference “RHEA:25359”
phycoerythrobilin synthase activity created by “dragon-ai-agent”
phycoerythrobilin synthase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31443”^^anyURI
phycoerythrobilin synthase activity exactMatch 1.3.7.6
phycoerythrobilin synthase activity has_obo_namespace “molecular_function”
phycoerythrobilin synthase activity label “phycoerythrobilin synthase activity”
phycoerythrobilin synthase activity id “GO:7770044”
phycoerythrobilin synthase activity exactMatch 25359
phycoerythrobilin synthase activity database_cross_reference “EC:1.3.7.6”
phycoerythrobilin synthase activity database_cross_reference “RHEA:25359”
phycoerythrobilin synthase activity creation date “2026-01-30T04:39:58Z”
Class: phycoerythrobilin synthase activity
phycoerythrobilin synthase activity SubClassOf oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

phytanate-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0050197`

Removed

phytanate-CoA ligase activity SubClassOf acid-thiol ligase activity

phytochelatin import into vacuole `http://purl.obolibrary.org/obo/GO_0071995`

Added

phytochelatin import into vacuole SubClassOf intercellular transport

phytosteroid biosynthetic process `http://purl.obolibrary.org/obo/GO_0016129`

Removed

phytosteroid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of phytosteroids, steroids that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi.”
- database_cross_reference “GOC:mah”
- database_cross_reference “ISBN:0471331309”
- database_cross_reference “GOC:go_curators”

Added

phytosteroid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of phytosteroids, steroids that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0471331309”

phytosteroid catabolic process `http://purl.obolibrary.org/obo/GO_0016130`

Removed

phytosteroid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of phytosteroids, steroids that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:go_curators”

Added

phytosteroid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of phytosteroids, steroids that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:curators”

phytyl-P kinase activity `http://purl.obolibrary.org/obo/GO_0102763`

Added

phytyl-P kinase activity narrowMatch 49276
phytyl-P kinase activity database_cross_reference “RHEA:49276”

piecemeal microautophagy of the nucleus `http://purl.obolibrary.org/obo/GO_0034727`

Added

piecemeal microautophagy of the nucleus term tracker item “https://github.com/geneontology/go-ontology/issues/31715”^^anyURI
piecemeal microautophagy of the nucleus has_broad_synonym “micronucleophagy”
- database_cross_reference “PMID:18701704”

pilus retraction `http://purl.obolibrary.org/obo/GO_0043108`

Removed

pilus retraction definition “The process of withdrawing a pilus back into a cell.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:17355871”

Added

pilus retraction definition “The process of withdrawing a pilus back into a cell.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:17355871”

pituitary gonadotropin complex `http://purl.obolibrary.org/obo/GO_0061696`

Removed

pituitary gonadotropin complex SubClassOf part of some extracellular region
pituitary gonadotropin complex SubClassOf protein-containing complex

Added

pituitary gonadotropin complex SubClassOf extracellular protein-containing complex

plant-type cell wall `http://purl.obolibrary.org/obo/GO_0009505`

Removed

plant-type cell wall definition “A more or less rigid structure lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances.”
- database_cross_reference “ISBN:0471245208”

Added

plant-type cell wall definition “A more or less rigid structure lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances.”
- database_cross_reference “PMID:39878232”
- database_cross_reference “ISBN:0471245208”

plant-type cell wall biogenesis `http://purl.obolibrary.org/obo/GO_0009832`

Removed

plant-type cell wall biogenesis definition “A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellulose and pectin-containing cell wall. An example of this is found in Arabidopsis thaliana.”
- database_cross_reference “GOC:lr”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_sensu”

Added

plant-type cell wall biogenesis definition “A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellulose and pectin-containing cell wall. An example of this is found in Arabidopsis thaliana.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:lr”
- database_cross_reference “GOC:mtg_sensu”

plantlet formation on parent plant `http://purl.obolibrary.org/obo/GO_0048624`

Removed

plantlet formation on parent plant definition “The process in which a new plantlet develops from a meristem on the plant body. As part of this process, when the plantlet is large enough to live independently, the physical connection between the new plantlet and the main plant is severed.”
- database_cross_reference “GOC:go_curators”

Added

plantlet formation on parent plant definition “The process in which a new plantlet develops from a meristem on the plant body. As part of this process, when the plantlet is large enough to live independently, the physical connection between the new plantlet and the main plant is severed.”
- database_cross_reference “GOC:curators”

plasma lipoprotein particle `http://purl.obolibrary.org/obo/GO_0034358`

Removed

plasma lipoprotein particle SubClassOf part of some obsolete extracellular space

Added

plasma lipoprotein particle SubClassOf extracellular protein-containing complex

plasmalogen synthase activity `http://purl.obolibrary.org/obo/GO_0047159`

Added

plasmalogen synthase activity narrowMatch 37627
plasmalogen synthase activity database_cross_reference “RHEA:37819”
plasmalogen synthase activity database_cross_reference “RHEA:37627”
plasmalogen synthase activity database_cross_reference “RHEA:37711”
plasmalogen synthase activity narrowMatch 37819
plasmalogen synthase activity narrowMatch 37711

plasmanylethanolamine desaturase activity `http://purl.obolibrary.org/obo/GO_0050207`

Added

plasmanylethanolamine desaturase activity narrowMatch 61968
plasmanylethanolamine desaturase activity database_cross_reference “RHEA:61960”
plasmanylethanolamine desaturase activity narrowMatch 61964
plasmanylethanolamine desaturase activity database_cross_reference “RHEA:61968”
plasmanylethanolamine desaturase activity narrowMatch 61972
plasmanylethanolamine desaturase activity narrowMatch 61960
plasmanylethanolamine desaturase activity database_cross_reference “RHEA:61964”
plasmanylethanolamine desaturase activity database_cross_reference “RHEA:61972”

plastid membrane `http://purl.obolibrary.org/obo/GO_0042170`

Removed

plastid membrane definition “Either of the lipid bilayers that surround a plastid and form the plastid envelope.”
- database_cross_reference “GOC:mah”

Added

plastid membrane definition “Any lipid bilayer that surrounds a plastid or is part of the plastid envelope. Primary plastids (in plants, green algae, red algae, and glaucophytes) are surrounded by two membranes; complex plastids derived from secondary endosymbiosis are surrounded by three or four membranes.”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:20124341”

plastid to vacuole vesicle-mediated transport `http://purl.obolibrary.org/obo/GO_1904962`

Added

plastid to vacuole vesicle-mediated transport SubClassOf intercellular transport

plastid translation `http://purl.obolibrary.org/obo/GO_0032544`

Removed

plastid translation definition “The chemical reactions and pathways resulting in the formation of a protein in a plastid. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the plastid has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.”
- database_cross_reference “GOC:go_curators”

Added

plastid translation definition “The chemical reactions and pathways resulting in the formation of a protein in a plastid. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the plastid has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.”
- database_cross_reference “GOC:curators”

plastoquinone biosynthetic process `http://purl.obolibrary.org/obo/GO_0010236`

Added

plastoquinone biosynthetic process database_cross_reference “MetaCyc:PWY-6978”
plastoquinone biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
plastoquinone biosynthetic process narrowMatch PWY-6978
plastoquinone biosynthetic process narrowMatch PWY-1581

platelet glycocalyx `http://purl.obolibrary.org/obo/GO_0120240`

Added

platelet glycocalyx term tracker item “https://github.com/geneontology/go-ontology/issues/31720”^^anyURI

platelet-activating factor acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0047179`

Added

polarity specification of anterior/posterior axis `http://purl.obolibrary.org/obo/GO_0009949`

Removed

polarity specification of anterior/posterior axis definition “Any process resulting in the establishment of polarity along the anterior/posterior axis.”
- database_cross_reference “GOC:go_curators”

Added

polarity specification of anterior/posterior axis definition “Any process resulting in the establishment of polarity along the anterior/posterior axis.”
- database_cross_reference “GOC:curators”

polarity specification of dorsal/ventral axis `http://purl.obolibrary.org/obo/GO_0009951`

Removed

polarity specification of dorsal/ventral axis definition “Any process resulting in the establishment of polarity along the dorsal/ventral axis.”
- database_cross_reference “GOC:go_curators”

Added

polarity specification of dorsal/ventral axis definition “Any process resulting in the establishment of polarity along the dorsal/ventral axis.”
- database_cross_reference “GOC:curators”

pole cell fate determination `http://purl.obolibrary.org/obo/GO_0007278`

Removed

pole cell fate determination definition “The cell fate determination process in which a cell becomes capable of differentiating autonomously into a pole cell regardless of its environment; upon determination, the cell fate cannot be reversed.”
- database_cross_reference “GOC:go_curators”

Added

pole cell fate determination definition “The cell fate determination process in which a cell becomes capable of differentiating autonomously into a pole cell regardless of its environment; upon determination, the cell fate cannot be reversed.”
- database_cross_reference “GOC:curators”

pole plasm oskar mRNA localization `http://purl.obolibrary.org/obo/GO_0045451`

Removed

pole plasm oskar mRNA localization definition “Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm.”
- database_cross_reference “GOC:go_curators”

Added

pole plasm oskar mRNA localization definition “Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm.”
- database_cross_reference “GOC:curators”

poly(A) RNA polymerase activity `http://purl.obolibrary.org/obo/GO_1990817`

Removed

poly(A) RNA polymerase activity database_cross_reference “Reactome:R-HSA-72185”
- label “mRNA polyadenylation”

Added

poly(A) RNA polymerase activity database_cross_reference “Reactome:R-HSA-9970320”
- label “PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS”
poly(A) RNA polymerase activity database_cross_reference “Reactome:R-HSA-9936998”
- label “MTPAP polyadenylates mitochondrial mRNA”
poly(A) RNA polymerase activity database_cross_reference “Reactome:R-HSA-9970189”
- label “PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3’UTR PAS”
poly(A) RNA polymerase activity database_cross_reference “Reactome:R-HSA-9970318”
- label “PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3’UTR PAS”

poly(A)-specific ribonuclease activity `http://purl.obolibrary.org/obo/GO_0004535`

Added

poly(A)-specific ribonuclease activity database_cross_reference “Reactome:R-HSA-9615042”
- label “Viral 2’,5’-PDE cleaves 2’-5’ oligoadenylates”
poly(A)-specific ribonuclease activity database_cross_reference “Reactome:R-HSA-9009950”
- label “PDE12 cleaves 2’-5’ oligoadenylates”

polyamine catabolic process `http://purl.obolibrary.org/obo/GO_0006598`

Added

polyamine catabolic process has_related_synonym “polyamine interconversion”
polyamine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31766”^^anyURI
polyamine catabolic process has_related_synonym “polyamine back-conversion”

polynucleotide 5’-phosphatase activity `http://purl.obolibrary.org/obo/GO_0004651`

Added

polynucleotide 5’-phosphatase activity database_cross_reference “Reactome:R-HSA-9923980”
- label “NS3 cleaves triphosphate moiety of genomic +ssRNA”

polyphosphate catabolic process `http://purl.obolibrary.org/obo/GO_0006798`

Removed

polyphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a polyphosphate, the anion or salt of polyphosphoric acid.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

polyphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a polyphosphate, the anion or salt of polyphosphoric acid.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

polyphosphate import into vacuole `http://purl.obolibrary.org/obo/GO_0180042`

Added

polyphosphate import into vacuole SubClassOf intercellular transport

polyphosphate metabolic process `http://purl.obolibrary.org/obo/GO_0006797`

Removed

polyphosphate metabolic process definition “The chemical reactions and pathways involving a polyphosphate, the anion or salt of polyphosphoric acid.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

polyphosphate metabolic process definition “The chemical reactions and pathways involving a polyphosphate, the anion or salt of polyphosphoric acid.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

polyprenal reductase activity `http://purl.obolibrary.org/obo/GO_0160198`

Added

polyprenal reductase activity database_cross_reference “Reactome:R-HSA-9937295”
- label “SRD5A3 reduces polyprenal to dolichal”

polyprenol biosynthetic process `http://purl.obolibrary.org/obo/GO_0016094`

Removed

polyprenol biosynthetic process definition “The chemical reactions and pathways resulting in the formation of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:11108713”

Added

polyprenol biosynthetic process definition “The chemical reactions and pathways resulting in the formation of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:11108713”

polyprenol catabolic process `http://purl.obolibrary.org/obo/GO_0016095`

Removed

polyprenol catabolic process definition “The chemical reactions and pathways resulting in the breakdown of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “Wikipedia:Polyprenol”

Added

polyprenol catabolic process definition “The chemical reactions and pathways resulting in the breakdown of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans.”
- database_cross_reference “GOC:curators”
- database_cross_reference “Wikipedia:Polyprenol”

polyprenol dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0160196`

Added

polyprenol dehydrogenase (NAD+) activity database_cross_reference “Reactome:R-HSA-9937298”
- label “DHRSX oxidizes polyprenol to polyprenal”

polyprenyldihydroxybenzoate methyltransferase activity `http://purl.obolibrary.org/obo/GO_0010420`

Added

polysaccharide biosynthetic process `http://purl.obolibrary.org/obo/GO_0000271`

Removed

polysaccharide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.”
- database_cross_reference “GOC:go_curators”

Added

polysaccharide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.”
- database_cross_reference “GOC:curators”

polysaccharide digestion `http://purl.obolibrary.org/obo/GO_0044245`

Removed

polysaccharide digestion definition “The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested polysaccharides into components that may be easily absorbed and directed into metabolism.”
- database_cross_reference “GOC:go_curators”

Added

polysaccharide digestion definition “The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested polysaccharides into components that may be easily absorbed and directed into metabolism.”
- database_cross_reference “GOC:curators”

polysaccharide transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015159`

Added

polysaccharide transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9932121”
- label “Unknown transporter exports CA to extracellular space”
polysaccharide transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9932466”
- label “Bcs complex exports pEtN-cellulose”

polyterpenoid biosynthetic process `http://purl.obolibrary.org/obo/GO_0016112`

Removed

polyterpenoid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of polyterpenoid compounds, terpenoids with more than eight isoprene units.”
- database_cross_reference “GOC:go_curators”

Added

polyterpenoid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of polyterpenoid compounds, terpenoids with more than eight isoprene units.”
- database_cross_reference “GOC:curators”

polyterpenoid catabolic process `http://purl.obolibrary.org/obo/GO_0016113`

Removed

polyterpenoid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of polyterpenoid compounds, terpenoids with more than eight isoprene units.”
- database_cross_reference “GOC:go_curators”

Added

polyterpenoid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of polyterpenoid compounds, terpenoids with more than eight isoprene units.”
- database_cross_reference “GOC:curators”

porin activity `http://purl.obolibrary.org/obo/GO_0015288`

Added

porin activity database_cross_reference “Reactome:R-HSA-9914083”
- label “MdtE:MdtF:TolC exports beta-lactams to extracellular space”
porin activity database_cross_reference “Reactome:R-HSA-9911516”
- label “AcrA:AcrB:TolC transports antibiotics from the periplasm to the extracellular region”
porin activity database_cross_reference “Reactome:R-HSA-9911510”
- label “MacA:MacB:TolC transports azithromycin from the periplasm to the extracellular region”
porin activity database_cross_reference “Reactome:R-HSA-9926021”
- label “HlyB:HlyD:TolC transports HlyA from periplasm to extracellular space”
porin activity database_cross_reference “Reactome:R-HSA-9760573”
- label “TolC complex exports STa”

positive regulation of ‘de novo’ NAD biosynthetic process from L-tryptophan `http://purl.obolibrary.org/obo/GO_1905014`

Removed

positive regulation of ‘de novo’ NAD biosynthetic process from L-tryptophan SubClassOf obsolete positive regulation of L-tryptophan metabolic process

Added

positive regulation of ‘de novo’ NAD biosynthetic process from L-tryptophan SubClassOf positive regulation of amino acid metabolic process

positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_1902648`

Removed

positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process SubClassOf positive regulation of phosphatidylinositol biosynthetic process

Added

positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process SubClassOf positive regulation of phospholipid biosynthetic process

positive regulation of B cell differentiation `http://purl.obolibrary.org/obo/GO_0045579`

Removed

positive regulation of B cell differentiation definition “Any process that activates or increases the frequency, rate or extent of B cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of B cell differentiation definition “Any process that activates or increases the frequency, rate or extent of B cell differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of BMP signaling pathway `http://purl.obolibrary.org/obo/GO_0030513`

Removed

positive regulation of BMP signaling pathway definition “Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of BMP signaling pathway definition “Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.”
- database_cross_reference “GOC:curators”

positive regulation of DNA recombination `http://purl.obolibrary.org/obo/GO_0045911`

Removed

positive regulation of DNA recombination definition “Any process that activates or increases the frequency, rate or extent of DNA recombination.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of DNA recombination definition “Any process that activates or increases the frequency, rate or extent of DNA recombination.”
- database_cross_reference “GOC:curators”

positive regulation of DNA repair `http://purl.obolibrary.org/obo/GO_0045739`

Removed

positive regulation of DNA repair definition “Any process that activates or increases the frequency, rate or extent of DNA repair.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of DNA repair definition “Any process that activates or increases the frequency, rate or extent of DNA repair.”
- database_cross_reference “GOC:curators”

positive regulation of DNA replication `http://purl.obolibrary.org/obo/GO_0045740`

Removed

positive regulation of DNA replication definition “Any process that activates or increases the frequency, rate or extent of DNA replication.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of DNA replication definition “Any process that activates or increases the frequency, rate or extent of DNA replication.”
- database_cross_reference “GOC:curators”

positive regulation of DNA-templated transcription `http://purl.obolibrary.org/obo/GO_0045893`

Removed

positive regulation of DNA-templated transcription definition “Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:txnOH”

Added

positive regulation of DNA-templated transcription definition “Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:txnOH”

positive regulation of G protein-coupled receptor signaling pathway `http://purl.obolibrary.org/obo/GO_0045745`

Removed

positive regulation of G protein-coupled receptor signaling pathway definition “Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of G protein-coupled receptor signaling pathway definition “Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity.”
- database_cross_reference “GOC:curators”

positive regulation of GABA catabolic process `http://purl.obolibrary.org/obo/GO_1901717`

Removed

positive regulation of GABA catabolic process has_exact_synonym “positive regulation of GABA catabolic process”
- database_cross_reference “GOC:TermGenie”
positive regulation of GABA catabolic process label “positive regulation of gamma-aminobutyric acid catabolic process”

Added

positive regulation of GABA catabolic process has_exact_synonym “positive regulation of gamma-aminobutyric acid catabolic process”
- database_cross_reference “GOC:TermGenie”
positive regulation of GABA catabolic process label “positive regulation of GABA catabolic process”

positive regulation of MAP kinase activity `http://purl.obolibrary.org/obo/GO_0043406`

Removed

positive regulation of MAP kinase activity definition “Any process that activates or increases the frequency, rate or extent of MAP kinase activity.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of MAP kinase activity definition “Any process that activates or increases the frequency, rate or extent of MAP kinase activity.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”

positive regulation of MAPK cascade `http://purl.obolibrary.org/obo/GO_0043410`

Removed

positive regulation of MAPK cascade definition “Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of MAPK cascade definition “Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.”
- database_cross_reference “GOC:curators”

positive regulation of MHC class I biosynthetic process `http://purl.obolibrary.org/obo/GO_0045345`

Removed

positive regulation of MHC class I biosynthetic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of MHC class I biosynthetic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I.”
- database_cross_reference “GOC:curators”

positive regulation of MHC class II biosynthetic process `http://purl.obolibrary.org/obo/GO_0045348`

Removed

positive regulation of MHC class II biosynthetic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of MHC class II biosynthetic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II.”
- database_cross_reference “GOC:curators”

positive regulation of Notch signaling pathway `http://purl.obolibrary.org/obo/GO_0045747`

Removed

positive regulation of Notch signaling pathway definition “Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of Notch signaling pathway definition “Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway.”
- database_cross_reference “GOC:curators”

positive regulation of R7 cell differentiation `http://purl.obolibrary.org/obo/GO_0045678`

Removed

positive regulation of R7 cell differentiation definition “Any process that activates or increases the frequency, rate or extent of R7 cell differentiation.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

positive regulation of R7 cell differentiation definition “Any process that activates or increases the frequency, rate or extent of R7 cell differentiation.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

positive regulation of R8 cell differentiation `http://purl.obolibrary.org/obo/GO_0045681`

Removed

positive regulation of R8 cell differentiation definition “Any process that activates or increases the frequency, rate or extent of R8 cell differentiation.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

positive regulation of R8 cell differentiation definition “Any process that activates or increases the frequency, rate or extent of R8 cell differentiation.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

positive regulation of R8 cell spacing in compound eye `http://purl.obolibrary.org/obo/GO_0045748`

Removed

positive regulation of R8 cell spacing in compound eye definition “Any process that activates or enforces the correct R8 cell spacing in a compound eye.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

positive regulation of R8 cell spacing in compound eye definition “Any process that activates or enforces the correct R8 cell spacing in a compound eye.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

positive regulation of RNA polymerase II transcription preinitiation complex assembly `http://purl.obolibrary.org/obo/GO_0045899`

Removed

positive regulation of RNA polymerase II transcription preinitiation complex assembly definition “Any process that activates or increases the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of RNA polymerase II transcription preinitiation complex assembly definition “Any process that activates or increases the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.”
- database_cross_reference “GOC:curators”

positive regulation of T cell differentiation `http://purl.obolibrary.org/obo/GO_0045582`

Removed

positive regulation of T cell differentiation definition “Any process that activates or increases the frequency, rate or extent of T cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of T cell differentiation definition “Any process that activates or increases the frequency, rate or extent of T cell differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of T-helper 1 cell differentiation `http://purl.obolibrary.org/obo/GO_0045627`

Removed

positive regulation of T-helper 1 cell differentiation definition “Any process that activates or increases the frequency, rate or extent of T-helper 1 cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of T-helper 1 cell differentiation definition “Any process that activates or increases the frequency, rate or extent of T-helper 1 cell differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of T-helper 2 cell differentiation `http://purl.obolibrary.org/obo/GO_0045630`

Removed

positive regulation of T-helper 2 cell differentiation definition “Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of T-helper 2 cell differentiation definition “Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of T-helper cell differentiation `http://purl.obolibrary.org/obo/GO_0045624`

Removed

positive regulation of T-helper cell differentiation definition “Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of T-helper cell differentiation definition “Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of Toll signaling pathway `http://purl.obolibrary.org/obo/GO_0045752`

Removed

positive regulation of Toll signaling pathway definition “Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of Toll signaling pathway definition “Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway.”
- database_cross_reference “GOC:curators”

positive regulation of Wnt signaling pathway `http://purl.obolibrary.org/obo/GO_0030177`

Removed

positive regulation of Wnt signaling pathway definition “Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

positive regulation of Wnt signaling pathway definition “Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

positive regulation of Wnt signaling pathway, calcium modulating pathway `http://purl.obolibrary.org/obo/GO_0045813`

Removed

positive regulation of Wnt signaling pathway, calcium modulating pathway definition “Any process that activates or increases the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of Wnt signaling pathway, calcium modulating pathway definition “Any process that activates or increases the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).”
- database_cross_reference “GOC:curators”

positive regulation of acetate catabolic process `http://purl.obolibrary.org/obo/GO_0045754`

Removed

positive regulation of acetate catabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of acetate catabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate.”
- database_cross_reference “GOC:curators”

positive regulation of acetyl-CoA biosynthesis `http://purl.obolibrary.org/obo/GO_0140390`

Added

positive regulation of acetyl-CoA biosynthesis label “positive regulation of acetyl-CoA biosynthesis”
positive regulation of acetyl-CoA biosynthesis creation date “2026-03-04T08:21:53Z”
positive regulation of acetyl-CoA biosynthesis id “GO:0140390”
positive regulation of acetyl-CoA biosynthesis has_obo_namespace “biological_process”
positive regulation of acetyl-CoA biosynthesis term tracker item “https://github.com/geneontology/go-ontology/issues/31614”^^anyURI
positive regulation of acetyl-CoA biosynthesis created by “pg”
positive regulation of acetyl-CoA biosynthesis definition “Any process that increases the rate, frequency, or extent of acetyl-CoA biosynthetic process.”
- database_cross_reference “PMID:41730913”
Class: positive regulation of acetyl-CoA biosynthesis
positive regulation of acetyl-CoA biosynthesis EquivalentTo biological regulation and (positively regulates some acetyl-CoA biosynthetic process)
positive regulation of acetyl-CoA biosynthesis SubClassOf regulation of acyl-CoA biosynthetic process
positive regulation of acetyl-CoA biosynthesis SubClassOf positively regulates some acetyl-CoA biosynthetic process
positive regulation of acetyl-CoA biosynthesis SubClassOf positive regulation of phosphate metabolic process
positive regulation of acetyl-CoA biosynthesis SubClassOf positive regulation of small molecule metabolic process
positive regulation of acetyl-CoA biosynthesis SubClassOf positive regulation of biosynthetic process

positive regulation of action potential `http://purl.obolibrary.org/obo/GO_0045760`

Removed

positive regulation of action potential definition “Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of action potential definition “Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.”
- database_cross_reference “GOC:curators”

positive regulation of adenylate cyclase activity `http://purl.obolibrary.org/obo/GO_0045762`

Removed

positive regulation of adenylate cyclase activity definition “Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of adenylate cyclase activity definition “Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity.”
- database_cross_reference “GOC:curators”

positive regulation of adult salivary gland boundary specification `http://purl.obolibrary.org/obo/GO_0045711`

Removed

positive regulation of adult salivary gland boundary specification definition “Any process that activates or increases the frequency, rate or extent of salivary gland determination in an adult organism.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

positive regulation of adult salivary gland boundary specification definition “Any process that activates or increases the frequency, rate or extent of salivary gland determination in an adult organism.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

positive regulation of alcohol biosynthetic process `http://purl.obolibrary.org/obo/GO_1902932`

Added

positive regulation of alcohol biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31485”^^anyURI
positive regulation of alcohol biosynthetic process in_subset gocheck_do_not_annotate

positive regulation of alcohol catabolic process `http://purl.obolibrary.org/obo/GO_1900421`

Added

positive regulation of alcohol catabolic process in_subset gocheck_do_not_annotate
positive regulation of alcohol catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31485”^^anyURI

positive regulation of amino acid metabolic process `http://purl.obolibrary.org/obo/GO_0045764`

Removed

positive regulation of amino acid metabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of amino acid metabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid.”
- database_cross_reference “GOC:curators”

positive regulation of amyloid precursor protein biosynthetic process `http://purl.obolibrary.org/obo/GO_0042986`

Removed

positive regulation of amyloid precursor protein biosynthetic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of amyloid precursor protein biosynthetic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.”
- database_cross_reference “GOC:curators”

positive regulation of angiogenesis `http://purl.obolibrary.org/obo/GO_0045766`

Removed

positive regulation of angiogenesis definition “Any process that activates or increases angiogenesis.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of angiogenesis definition “Any process that activates or increases angiogenesis.”
- database_cross_reference “GOC:curators”

positive regulation of antipodal cell differentiation `http://purl.obolibrary.org/obo/GO_0045690`

Removed

positive regulation of antipodal cell differentiation definition “Any process that activates or increases the frequency, rate or extent of antipodal cell differentiation.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_plant”

Added

positive regulation of antipodal cell differentiation definition “Any process that activates or increases the frequency, rate or extent of antipodal cell differentiation.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_plant”

positive regulation of asymmetric cell division `http://purl.obolibrary.org/obo/GO_0045770`

Removed

positive regulation of asymmetric cell division definition “Any process that activates or increases the frequency, rate or extent of asymmetric cell division.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of asymmetric cell division definition “Any process that activates or increases the frequency, rate or extent of asymmetric cell division.”
- database_cross_reference “GOC:curators”

positive regulation of autophagosome size `http://purl.obolibrary.org/obo/GO_0045772`

Removed

positive regulation of autophagosome size definition “Any process that increases autophagosome size.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:autophagy”

Added

positive regulation of autophagosome size definition “Any process that increases autophagosome size.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:autophagy”

positive regulation of axon extension `http://purl.obolibrary.org/obo/GO_0045773`

Removed

positive regulation of axon extension definition “Any process that activates or increases the frequency, rate or extent of axon extension.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of axon extension definition “Any process that activates or increases the frequency, rate or extent of axon extension.”
- database_cross_reference “GOC:curators”

positive regulation of basophil differentiation `http://purl.obolibrary.org/obo/GO_0045642`

Removed

positive regulation of basophil differentiation definition “Any process that activates or increases the frequency, rate or extent of basophil differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of basophil differentiation definition “Any process that activates or increases the frequency, rate or extent of basophil differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of beta 2 integrin biosynthetic process `http://purl.obolibrary.org/obo/GO_0045775`

Removed

positive regulation of beta 2 integrin biosynthetic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of beta 2 integrin biosynthetic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins.”
- database_cross_reference “GOC:curators”

positive regulation of bicoid mRNA localization `http://purl.obolibrary.org/obo/GO_0045854`

Removed

positive regulation of bicoid mRNA localization definition “Any process that activates or increases the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of bicoid mRNA localization definition “Any process that activates or increases the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location.”
- database_cross_reference “GOC:curators”

positive regulation of biosynthetic process `http://purl.obolibrary.org/obo/GO_0009891`

Removed

positive regulation of biosynthetic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of biosynthetic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.”
- database_cross_reference “GOC:curators”

positive regulation of blood pressure `http://purl.obolibrary.org/obo/GO_0045777`

Removed

positive regulation of blood pressure definition “Any process in which the force of blood traveling through the circulatory system is increased.”
- database_cross_reference “GOC:mtg_cardio”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of blood pressure definition “Any process in which the force of blood traveling through the circulatory system is increased.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_cardio”

positive regulation of blood vessel endothelial cell migration `http://purl.obolibrary.org/obo/GO_0043536`

Removed

positive regulation of blood vessel endothelial cell migration definition “Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of blood vessel endothelial cell migration definition “Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.”
- database_cross_reference “GOC:curators”

positive regulation of bone mineralization `http://purl.obolibrary.org/obo/GO_0030501`

Removed

positive regulation of bone mineralization definition “Any process that activates or increases the frequency, rate or extent of bone mineralization.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of bone mineralization definition “Any process that activates or increases the frequency, rate or extent of bone mineralization.”
- database_cross_reference “GOC:curators”

positive regulation of bone resorption `http://purl.obolibrary.org/obo/GO_0045780`

Removed

positive regulation of bone resorption definition “Any process that activates or increases the frequency, rate or extent of bone resorption.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of bone resorption definition “Any process that activates or increases the frequency, rate or extent of bone resorption.”
- database_cross_reference “GOC:curators”

positive regulation of calcium ion-dependent exocytosis `http://purl.obolibrary.org/obo/GO_0045956`

Removed

positive regulation of calcium ion-dependent exocytosis definition “Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of calcium ion-dependent exocytosis definition “Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis.”
- database_cross_reference “GOC:curators”

positive regulation of carbohydrate metabolic process `http://purl.obolibrary.org/obo/GO_0045913`

Removed

positive regulation of carbohydrate metabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of carbohydrate metabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate.”
- database_cross_reference “GOC:curators”

positive regulation of catabolic process `http://purl.obolibrary.org/obo/GO_0009896`

Removed

positive regulation of catabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of catabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances.”
- database_cross_reference “GOC:curators”

positive regulation of cell adhesion `http://purl.obolibrary.org/obo/GO_0045785`

Removed

positive regulation of cell adhesion definition “Any process that activates or increases the frequency, rate or extent of cell adhesion.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of cell adhesion definition “Any process that activates or increases the frequency, rate or extent of cell adhesion.”
- database_cross_reference “GOC:curators”

positive regulation of cell budding `http://purl.obolibrary.org/obo/GO_0045782`

Removed

positive regulation of cell budding definition “Any process that activates or increases the frequency, rate or extent of cell budding.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of cell budding definition “Any process that activates or increases the frequency, rate or extent of cell budding.”
- database_cross_reference “GOC:curators”

positive regulation of cell cycle `http://purl.obolibrary.org/obo/GO_0045787`

Removed

positive regulation of cell cycle definition “Any process that activates or increases the rate or extent of progression through the cell cycle.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of cell cycle definition “Any process that activates or increases the rate or extent of progression through the cell cycle.”
- database_cross_reference “GOC:curators”

positive regulation of cell differentiation `http://purl.obolibrary.org/obo/GO_0045597`

Removed

positive regulation of cell differentiation definition “Any process that activates or increases the frequency, rate or extent of cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of cell differentiation definition “Any process that activates or increases the frequency, rate or extent of cell differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of cell fate specification `http://purl.obolibrary.org/obo/GO_0042660`

Removed

positive regulation of cell fate specification definition “Any process that activates or enables a cell to adopt a specific fate.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of cell fate specification definition “Any process that activates or enables a cell to adopt a specific fate.”
- database_cross_reference “GOC:curators”

positive regulation of cell growth `http://purl.obolibrary.org/obo/GO_0030307`

Removed

positive regulation of cell growth definition “Any process that activates or increases the frequency, rate, extent or direction of cell growth.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of cell growth definition “Any process that activates or increases the frequency, rate, extent or direction of cell growth.”
- database_cross_reference “GOC:curators”

positive regulation of cell migration `http://purl.obolibrary.org/obo/GO_0030335`

Removed

positive regulation of cell migration definition “Any process that activates or increases the frequency, rate or extent of cell migration.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of cell migration definition “Any process that activates or increases the frequency, rate or extent of cell migration.”
- database_cross_reference “GOC:curators”

positive regulation of cell population proliferation `http://purl.obolibrary.org/obo/GO_0008284`

Removed

positive regulation of cell population proliferation definition “Any process that activates or increases the rate or extent of cell proliferation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of cell population proliferation definition “Any process that activates or increases the rate or extent of cell proliferation.”
- database_cross_reference “GOC:curators”

positive regulation of cell size `http://purl.obolibrary.org/obo/GO_0045793`

Removed

positive regulation of cell size definition “Any process that increases cell size.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of cell size definition “Any process that increases cell size.”
- database_cross_reference “GOC:curators”

positive regulation of cell volume `http://purl.obolibrary.org/obo/GO_0045795`

Removed

positive regulation of cell volume definition “Any process that increases cell volume.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of cell volume definition “Any process that increases cell volume.”
- database_cross_reference “GOC:curators”

positive regulation of chitin-based cuticle tanning `http://purl.obolibrary.org/obo/GO_0045801`

Removed

positive regulation of chitin-based cuticle tanning definition “Any process that activates or increases the frequency, rate or extent of chitin-based cuticular tanning.”
- database_cross_reference “GOC:jid”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_sensu”

Added

positive regulation of chitin-based cuticle tanning definition “Any process that activates or increases the frequency, rate or extent of chitin-based cuticular tanning.”
- database_cross_reference “GOC:jid”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_sensu”

positive regulation of cholesterol biosynthetic process `http://purl.obolibrary.org/obo/GO_0045542`

Removed

positive regulation of cholesterol biosynthetic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of cholesterol biosynthetic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.”
- database_cross_reference “GOC:curators”

positive regulation of cilium assembly `http://purl.obolibrary.org/obo/GO_0045724`

Removed

positive regulation of cilium assembly definition “Any process that activates or increases the frequency, rate or extent of the formation of a cilium.”
- database_cross_reference “GOC:cilia”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of cilium assembly definition “Any process that activates or increases the frequency, rate or extent of the formation of a cilium.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:cilia”

positive regulation of circadian rhythm `http://purl.obolibrary.org/obo/GO_0042753`

Removed

positive regulation of circadian rhythm definition “Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of circadian rhythm definition “Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior.”
- database_cross_reference “GOC:curators”

positive regulation of circadian sleep/wake cycle, REM sleep `http://purl.obolibrary.org/obo/GO_0046005`

Removed

positive regulation of circadian sleep/wake cycle, REM sleep definition “Any process that activates or increases the duration or quality of rapid eye movement (REM) sleep.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of circadian sleep/wake cycle, REM sleep definition “Any process that activates or increases the duration or quality of rapid eye movement (REM) sleep.”
- database_cross_reference “GOC:curators”

positive regulation of circadian sleep/wake cycle, non-REM sleep `http://purl.obolibrary.org/obo/GO_0046010`

Removed

positive regulation of circadian sleep/wake cycle, non-REM sleep definition “Any process that activates or increases the duration or quality of non-rapid eye movement (NREM) sleep.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of circadian sleep/wake cycle, non-REM sleep definition “Any process that activates or increases the duration or quality of non-rapid eye movement (NREM) sleep.”
- database_cross_reference “GOC:curators”

positive regulation of circadian sleep/wake cycle, sleep `http://purl.obolibrary.org/obo/GO_0045938`

Removed

positive regulation of circadian sleep/wake cycle, sleep definition “Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of circadian sleep/wake cycle, sleep definition “Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.”
- database_cross_reference “GOC:curators”

positive regulation of complement activation `http://purl.obolibrary.org/obo/GO_0045917`

Removed

positive regulation of complement activation definition “Any process that activates or increases the frequency, rate or extent of complement activation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of complement activation definition “Any process that activates or increases the frequency, rate or extent of complement activation.”
- database_cross_reference “GOC:curators”

positive regulation of complement activation, alternative pathway `http://purl.obolibrary.org/obo/GO_0045958`

Removed

positive regulation of complement activation, alternative pathway definition “Any process that activates or increases the frequency, rate or extent of complement activation by the alternative pathway.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of complement activation, alternative pathway definition “Any process that activates or increases the frequency, rate or extent of complement activation by the alternative pathway.”
- database_cross_reference “GOC:curators”

positive regulation of complement activation, classical pathway `http://purl.obolibrary.org/obo/GO_0045960`

Removed

positive regulation of complement activation, classical pathway definition “Any process that activates or increases the frequency, rate or extent of complement activation by the classical pathway.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of complement activation, classical pathway definition “Any process that activates or increases the frequency, rate or extent of complement activation by the classical pathway.”
- database_cross_reference “GOC:curators”

positive regulation of crystal cell differentiation `http://purl.obolibrary.org/obo/GO_0042691`

Removed

positive regulation of crystal cell differentiation definition “Any process that activates or increases the frequency, rate or extent of crystal cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of crystal cell differentiation definition “Any process that activates or increases the frequency, rate or extent of crystal cell differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of cumulus cell differentiation `http://purl.obolibrary.org/obo/GO_0045594`

Removed

positive regulation of cumulus cell differentiation definition “Any process that activates or increases the frequency, rate or extent of ovarian cumulus cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of cumulus cell differentiation definition “Any process that activates or increases the frequency, rate or extent of ovarian cumulus cell differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of cyclin-dependent protein serine/threonine kinase activity `http://purl.obolibrary.org/obo/GO_0045737`

Removed

positive regulation of cyclin-dependent protein serine/threonine kinase activity definition “Any process that activates or increases the frequency, rate or extent of CDK activity.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:pr”

Added

positive regulation of cyclin-dependent protein serine/threonine kinase activity definition “Any process that activates or increases the frequency, rate or extent of CDK activity.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:pr”

positive regulation of cytochrome-c oxidase activity `http://purl.obolibrary.org/obo/GO_1904960`

Added

positive regulation of cytochrome-c oxidase activity SubClassOf positive regulation of oxidoreductase activity

positive regulation of cytolysis `http://purl.obolibrary.org/obo/GO_0045919`

Removed

positive regulation of cytolysis definition “Any process that activates or increases the frequency, rate or extent of cytolysis.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of cytolysis definition “Any process that activates or increases the frequency, rate or extent of cytolysis.”
- database_cross_reference “GOC:curators”

positive regulation of cytotoxic T cell differentiation `http://purl.obolibrary.org/obo/GO_0045585`

Removed

positive regulation of cytotoxic T cell differentiation definition “Any process that activates or increases the frequency, rate or extent of cytotoxic T cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of cytotoxic T cell differentiation definition “Any process that activates or increases the frequency, rate or extent of cytotoxic T cell differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of development, heterochronic `http://purl.obolibrary.org/obo/GO_0045962`

Removed

positive regulation of development, heterochronic definition “Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and increases the rate at which this time point is reached.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of development, heterochronic definition “Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and increases the rate at which this time point is reached.”
- database_cross_reference “GOC:curators”

positive regulation of developmental growth `http://purl.obolibrary.org/obo/GO_0048639`

Removed

positive regulation of developmental growth definition “Any process that activates, maintains or increases the rate of developmental growth.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of developmental growth definition “Any process that activates, maintains or increases the rate of developmental growth.”
- database_cross_reference “GOC:curators”

positive regulation of dopamine metabolic process `http://purl.obolibrary.org/obo/GO_0045964`

Removed

positive regulation of dopamine metabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving dopamine.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of dopamine metabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving dopamine.”
- database_cross_reference “GOC:curators”

positive regulation of ecdysteroid biosynthetic process `http://purl.obolibrary.org/obo/GO_0045998`

Removed

positive regulation of ecdysteroid biosynthetic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of ecdysteroid biosynthetic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids.”
- database_cross_reference “GOC:curators”

positive regulation of ecdysteroid secretion `http://purl.obolibrary.org/obo/GO_0046000`

Removed

positive regulation of ecdysteroid secretion definition “Any process that activates or increases the frequency, rate or extent of the regulated release of ecdysteroid.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of ecdysteroid secretion definition “Any process that activates or increases the frequency, rate or extent of the regulated release of ecdysteroid.”
- database_cross_reference “GOC:curators”

positive regulation of eclosion `http://purl.obolibrary.org/obo/GO_0045805`

Removed

positive regulation of eclosion definition “Any process that activates or increases the frequency, rate or extent of eclosion.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of eclosion definition “Any process that activates or increases the frequency, rate or extent of eclosion.”
- database_cross_reference “GOC:curators”

positive regulation of embryo sac central cell differentiation `http://purl.obolibrary.org/obo/GO_0045693`

Removed

positive regulation of embryo sac central cell differentiation definition “Any process that activates or increases the frequency, rate or extent of embryo sac central cell differentiation.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_plant”

Added

positive regulation of embryo sac central cell differentiation definition “Any process that activates or increases the frequency, rate or extent of embryo sac central cell differentiation.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_plant”

positive regulation of embryo sac egg cell differentiation `http://purl.obolibrary.org/obo/GO_0045696`

Removed

positive regulation of embryo sac egg cell differentiation definition “Any process that activates or increases the frequency, rate or extent of embryo sac egg cell differentiation.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_plant”

Added

positive regulation of embryo sac egg cell differentiation definition “Any process that activates or increases the frequency, rate or extent of embryo sac egg cell differentiation.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_plant”

positive regulation of embryonic development `http://purl.obolibrary.org/obo/GO_0040019`

Removed

positive regulation of embryonic development definition “Any process that activates or increases the frequency, rate or extent of embryonic development.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of embryonic development definition “Any process that activates or increases the frequency, rate or extent of embryonic development.”
- database_cross_reference “GOC:curators”

positive regulation of endocytosis `http://purl.obolibrary.org/obo/GO_0045807`

Removed

positive regulation of endocytosis definition “Any process that activates or increases the frequency, rate or extent of endocytosis.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of endocytosis definition “Any process that activates or increases the frequency, rate or extent of endocytosis.”
- database_cross_reference “GOC:curators”

positive regulation of endopeptidase activity `http://purl.obolibrary.org/obo/GO_0010950`

Added

positive regulation of endopeptidase activity database_cross_reference “Reactome:R-HSA-140534”
- label “Caspase activation via Death Receptors in the presence of ligand”

positive regulation of endothelial cell differentiation `http://purl.obolibrary.org/obo/GO_0045603`

Removed

positive regulation of endothelial cell differentiation definition “Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of endothelial cell differentiation definition “Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of eosinophil differentiation `http://purl.obolibrary.org/obo/GO_0045645`

Removed

positive regulation of eosinophil differentiation definition “Any process that activates or increases the frequency, rate or extent of eosinophil differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of eosinophil differentiation definition “Any process that activates or increases the frequency, rate or extent of eosinophil differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of epidermal cell differentiation `http://purl.obolibrary.org/obo/GO_0045606`

Removed

positive regulation of epidermal cell differentiation definition “Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of epidermal cell differentiation definition “Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of epidermal growth factor receptor signaling pathway `http://purl.obolibrary.org/obo/GO_0045742`

Removed

positive regulation of epidermal growth factor receptor signaling pathway definition “Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of epidermal growth factor receptor signaling pathway definition “Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.”
- database_cross_reference “GOC:curators”

positive regulation of epidermis development `http://purl.obolibrary.org/obo/GO_0045684`

Removed

positive regulation of epidermis development definition “Any process that activates or increases the frequency, rate or extent of epidermis development.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of epidermis development definition “Any process that activates or increases the frequency, rate or extent of epidermis development.”
- database_cross_reference “GOC:curators”

positive regulation of erythrocyte differentiation `http://purl.obolibrary.org/obo/GO_0045648`

Removed

positive regulation of erythrocyte differentiation definition “Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of erythrocyte differentiation definition “Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of establishment of competence for transformation `http://purl.obolibrary.org/obo/GO_0045809`

Removed

positive regulation of establishment of competence for transformation definition “Any process that activates or increases the frequency, rate or extent of establishment of competence for transformation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of establishment of competence for transformation definition “Any process that activates or increases the frequency, rate or extent of establishment of competence for transformation.”
- database_cross_reference “GOC:curators”

positive regulation of exocytosis `http://purl.obolibrary.org/obo/GO_0045921`

Removed

positive regulation of exocytosis definition “Any process that activates or increases the frequency, rate or extent of exocytosis.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of exocytosis definition “Any process that activates or increases the frequency, rate or extent of exocytosis.”
- database_cross_reference “GOC:curators”

positive regulation of fat cell differentiation `http://purl.obolibrary.org/obo/GO_0045600`

Removed

positive regulation of fat cell differentiation definition “Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of fat cell differentiation definition “Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of fatty acid biosynthetic process `http://purl.obolibrary.org/obo/GO_0045723`

Removed

positive regulation of fatty acid biosynthetic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of fatty acid biosynthetic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids.”
- database_cross_reference “GOC:curators”

positive regulation of fatty acid metabolic process `http://purl.obolibrary.org/obo/GO_0045923`

Removed

positive regulation of fatty acid metabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of fatty acid metabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.”
- database_cross_reference “GOC:curators”

positive regulation of female receptivity `http://purl.obolibrary.org/obo/GO_0045925`

Removed

positive regulation of female receptivity definition “Any process that activates or increases the receptiveness of a female to male advances.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of female receptivity definition “Any process that activates or increases the receptiveness of a female to male advances.”
- database_cross_reference “GOC:curators”

positive regulation of female receptivity, post-mating `http://purl.obolibrary.org/obo/GO_0046009`

Removed

positive regulation of female receptivity, post-mating definition “Any process that increases the receptiveness of a female to male advances subsequent to mating.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of female receptivity, post-mating definition “Any process that increases the receptiveness of a female to male advances subsequent to mating.”
- database_cross_reference “GOC:curators”

positive regulation of fibroblast growth factor receptor signaling pathway `http://purl.obolibrary.org/obo/GO_0045743`

Removed

positive regulation of fibroblast growth factor receptor signaling pathway definition “Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of fibroblast growth factor receptor signaling pathway definition “Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.”
- database_cross_reference “GOC:curators”

positive regulation of flower development `http://purl.obolibrary.org/obo/GO_0009911`

Removed

positive regulation of flower development definition “Any process that activates or increases the frequency, rate or extent of flower development.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of flower development definition “Any process that activates or increases the frequency, rate or extent of flower development.”
- database_cross_reference “GOC:curators”

positive regulation of gamma-delta T cell differentiation `http://purl.obolibrary.org/obo/GO_0045588`

Removed

positive regulation of gamma-delta T cell differentiation definition “Any process that activates or increases the frequency, rate or extent of gamma-delta T cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of gamma-delta T cell differentiation definition “Any process that activates or increases the frequency, rate or extent of gamma-delta T cell differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of glial cell differentiation `http://purl.obolibrary.org/obo/GO_0045687`

Removed

positive regulation of glial cell differentiation definition “Any process that activates or increases the frequency, rate or extent of glia cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of glial cell differentiation definition “Any process that activates or increases the frequency, rate or extent of glia cell differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of gluconeogenesis `http://purl.obolibrary.org/obo/GO_0045722`

Removed

positive regulation of gluconeogenesis definition “Any process that activates or increases the frequency, rate or extent of gluconeogenesis.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of gluconeogenesis definition “Any process that activates or increases the frequency, rate or extent of gluconeogenesis.”
- database_cross_reference “GOC:curators”

positive regulation of glucose catabolic process to lactate via pyruvate `http://purl.obolibrary.org/obo/GO_1904025`

Removed

Added

positive regulation of glycogen biosynthetic process `http://purl.obolibrary.org/obo/GO_0045725`

Removed

positive regulation of glycogen biosynthetic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of glycogen biosynthetic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.”
- database_cross_reference “GOC:curators”

positive regulation of glycogen catabolic process `http://purl.obolibrary.org/obo/GO_0045819`

Removed

positive regulation of glycogen catabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of glycogen catabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.”
- database_cross_reference “GOC:curators”

positive regulation of glycolytic process `http://purl.obolibrary.org/obo/GO_0045821`

Removed

positive regulation of glycolytic process definition “Any process that activates or increases the frequency, rate or extent of glycolysis.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of glycolytic process definition “Any process that activates or increases the frequency, rate or extent of glycolysis.”
- database_cross_reference “GOC:curators”

positive regulation of growth `http://purl.obolibrary.org/obo/GO_0045927`

Removed

positive regulation of growth definition “Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of growth definition “Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism.”
- database_cross_reference “GOC:curators”

positive regulation of hair cycle `http://purl.obolibrary.org/obo/GO_0042635`

Removed

positive regulation of hair cycle definition “Any process that activates or increases the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair.”
- database_cross_reference “PMID:12230507”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of hair cycle definition “Any process that activates or increases the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair.”
- database_cross_reference “PMID:12230507”
- database_cross_reference “GOC:curators”

positive regulation of heart contraction `http://purl.obolibrary.org/obo/GO_0045823`

Removed

positive regulation of heart contraction definition “Any process that activates or increases the frequency, rate or extent of heart contraction.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of heart contraction definition “Any process that activates or increases the frequency, rate or extent of heart contraction.”
- database_cross_reference “GOC:curators”

positive regulation of hemocyte differentiation `http://purl.obolibrary.org/obo/GO_0045612`

Removed

positive regulation of hemocyte differentiation definition “Any process that activates or increases the frequency, rate or extent of hemocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of hemocyte differentiation definition “Any process that activates or increases the frequency, rate or extent of hemocyte differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of imaginal disc growth `http://purl.obolibrary.org/obo/GO_0045572`

Removed

positive regulation of imaginal disc growth definition “Any process that activates or increases the frequency, rate or extent of imaginal disc growth.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of imaginal disc growth definition “Any process that activates or increases the frequency, rate or extent of imaginal disc growth.”
- database_cross_reference “GOC:curators”

positive regulation of inner ear auditory receptor cell differentiation `http://purl.obolibrary.org/obo/GO_0045609`

Removed

positive regulation of inner ear auditory receptor cell differentiation definition “Any process that activates or increases the frequency, rate or extent of auditory hair cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of inner ear auditory receptor cell differentiation definition “Any process that activates or increases the frequency, rate or extent of auditory hair cell differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of insulin secretion `http://purl.obolibrary.org/obo/GO_0032024`

Added

positive regulation of insulin secretion database_cross_reference “Reactome:R-HSA-381676”
- label “Glucagon-like Peptide-1 (GLP1) regulates insulin secretion”
positive regulation of insulin secretion database_cross_reference “Reactome:R-HSA-400451”
- label “Free fatty acids regulate insulin secretion”

positive regulation of integrin biosynthetic process `http://purl.obolibrary.org/obo/GO_0045726`

Removed

positive regulation of integrin biosynthetic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of integrin biosynthetic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins.”
- database_cross_reference “GOC:curators”

positive regulation of intestinal cholesterol absorption `http://purl.obolibrary.org/obo/GO_0045797`

Removed

positive regulation of intestinal cholesterol absorption definition “Any process that activates or increases the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of intestinal cholesterol absorption definition “Any process that activates or increases the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine.”
- database_cross_reference “GOC:curators”

positive regulation of isotype switching `http://purl.obolibrary.org/obo/GO_0045830`

Removed

positive regulation of isotype switching definition “Any process that activates or increases the frequency, rate or extent of isotype switching.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of isotype switching definition “Any process that activates or increases the frequency, rate or extent of isotype switching.”
- database_cross_reference “GOC:curators”

positive regulation of juvenile hormone biosynthetic process `http://purl.obolibrary.org/obo/GO_0045969`

Removed

positive regulation of juvenile hormone biosynthetic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of juvenile hormone biosynthetic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone.”
- database_cross_reference “GOC:curators”

positive regulation of juvenile hormone catabolic process `http://purl.obolibrary.org/obo/GO_0045971`

Removed

positive regulation of juvenile hormone catabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of juvenile hormone catabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone.”
- database_cross_reference “GOC:curators”

positive regulation of juvenile hormone secretion `http://purl.obolibrary.org/obo/GO_0045973`

Removed

positive regulation of juvenile hormone secretion definition “Any process that activates or increases the frequency, rate or extent of the regulated release of juvenile hormone.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of juvenile hormone secretion definition “Any process that activates or increases the frequency, rate or extent of the regulated release of juvenile hormone.”
- database_cross_reference “GOC:curators”

positive regulation of keratinocyte differentiation `http://purl.obolibrary.org/obo/GO_0045618`

Removed

positive regulation of keratinocyte differentiation definition “Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of keratinocyte differentiation definition “Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of larval salivary gland boundary specification `http://purl.obolibrary.org/obo/GO_0045712`

Removed

positive regulation of larval salivary gland boundary specification definition “Any process that activates or increases the frequency, rate or extent of salivary gland determination in a larval organism.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

positive regulation of larval salivary gland boundary specification definition “Any process that activates or increases the frequency, rate or extent of salivary gland determination in a larval organism.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

positive regulation of lipid metabolic process `http://purl.obolibrary.org/obo/GO_0045834`

Removed

positive regulation of lipid metabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of lipid metabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids.”
- database_cross_reference “GOC:curators”

positive regulation of locomotion `http://purl.obolibrary.org/obo/GO_0040017`

Removed

positive regulation of locomotion definition “Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of locomotion definition “Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.”
- database_cross_reference “GOC:curators”

positive regulation of lymphocyte differentiation `http://purl.obolibrary.org/obo/GO_0045621`

Removed

positive regulation of lymphocyte differentiation definition “Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of lymphocyte differentiation definition “Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine `http://purl.obolibrary.org/obo/GO_2001196`

Removed

Added

positive regulation of macroautophagy `http://purl.obolibrary.org/obo/GO_0016239`

Removed

positive regulation of macroautophagy definition “Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.”
- database_cross_reference “PMID:9412464”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of macroautophagy definition “Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.”
- database_cross_reference “PMID:9412464”
- database_cross_reference “GOC:curators”

positive regulation of macromolecule biosynthetic process `http://purl.obolibrary.org/obo/GO_0010557`

Added

positive regulation of macromolecule biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31483”^^anyURI
positive regulation of macromolecule biosynthetic process in_subset gocheck_do_not_annotate

positive regulation of macrophage differentiation `http://purl.obolibrary.org/obo/GO_0045651`

Removed

positive regulation of macrophage differentiation definition “Any process that activates or increases the frequency, rate or extent of macrophage differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of macrophage differentiation definition “Any process that activates or increases the frequency, rate or extent of macrophage differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of mating-type specific transcription, DNA-templated `http://purl.obolibrary.org/obo/GO_0045895`

Removed

positive regulation of mating-type specific transcription, DNA-templated definition “Any mating-type specific process that activates or increases the rate of cellular DNA-templated transcription.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:txnOH”

Added

positive regulation of mating-type specific transcription, DNA-templated definition “Any mating-type specific process that activates or increases the rate of cellular DNA-templated transcription.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:txnOH”

positive regulation of mechanoreceptor differentiation `http://purl.obolibrary.org/obo/GO_0045633`

Removed

positive regulation of mechanoreceptor differentiation definition “Any process that activates or increases the frequency, rate or extent of mechanoreceptor differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of mechanoreceptor differentiation definition “Any process that activates or increases the frequency, rate or extent of mechanoreceptor differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of megakaryocyte differentiation `http://purl.obolibrary.org/obo/GO_0045654`

Removed

positive regulation of megakaryocyte differentiation definition “Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of megakaryocyte differentiation definition “Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of meiotic nuclear division `http://purl.obolibrary.org/obo/GO_0045836`

Removed

positive regulation of meiotic nuclear division definition “Any process that activates or increases the frequency, rate or extent of meiosis.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of meiotic nuclear division definition “Any process that activates or increases the frequency, rate or extent of meiosis.”
- database_cross_reference “GOC:curators”

positive regulation of melanocyte differentiation `http://purl.obolibrary.org/obo/GO_0045636`

Removed

positive regulation of melanocyte differentiation definition “Any process that activates or increases the frequency, rate or extent of melanocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of melanocyte differentiation definition “Any process that activates or increases the frequency, rate or extent of melanocyte differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of membrane potential `http://purl.obolibrary.org/obo/GO_0045838`

Removed

positive regulation of membrane potential definition “Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of membrane potential definition “Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.”
- database_cross_reference “GOC:curators”

positive regulation of metabolic process `http://purl.obolibrary.org/obo/GO_0009893`

Removed

positive regulation of metabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of metabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.”
- database_cross_reference “GOC:curators”
positive regulation of metabolic process database_cross_reference “Reactome:R-HSA-163765”
- label “ChREBP activates metabolic gene expression”

positive regulation of mitotic cell cycle `http://purl.obolibrary.org/obo/GO_0045931`

Removed

positive regulation of mitotic cell cycle definition “Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

positive regulation of mitotic cell cycle definition “Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

positive regulation of mitotic cell cycle, embryonic `http://purl.obolibrary.org/obo/GO_0045977`

Removed

positive regulation of mitotic cell cycle, embryonic definition “Any process that activates or increases the frequency, rate or extent of progression through the embryonic mitotic cell cycle.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

positive regulation of mitotic cell cycle, embryonic definition “Any process that activates or increases the frequency, rate or extent of progression through the embryonic mitotic cell cycle.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

positive regulation of mitotic metaphase/anaphase transition `http://purl.obolibrary.org/obo/GO_0045842`

Removed

positive regulation of mitotic metaphase/anaphase transition definition “Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of mitotic metaphase/anaphase transition definition “Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.”
- database_cross_reference “GOC:curators”

positive regulation of mitotic nuclear division `http://purl.obolibrary.org/obo/GO_0045840`

Removed

positive regulation of mitotic nuclear division definition “Any process that activates or increases the frequency, rate or extent of mitosis.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of mitotic nuclear division definition “Any process that activates or increases the frequency, rate or extent of mitosis.”
- database_cross_reference “GOC:curators”

positive regulation of mitotic recombination `http://purl.obolibrary.org/obo/GO_0045951`

Removed

positive regulation of mitotic recombination definition “Any process that activates or increases the frequency, rate or extent of DNA recombination during mitosis.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of mitotic recombination definition “Any process that activates or increases the frequency, rate or extent of DNA recombination during mitosis.”
- database_cross_reference “GOC:curators”

positive regulation of monocyte differentiation `http://purl.obolibrary.org/obo/GO_0045657`

Removed

positive regulation of monocyte differentiation definition “Any process that activates or increases the frequency, rate or extent of monocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of monocyte differentiation definition “Any process that activates or increases the frequency, rate or extent of monocyte differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of multicellular organism growth `http://purl.obolibrary.org/obo/GO_0040018`

Removed

positive regulation of multicellular organism growth definition “Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

positive regulation of multicellular organism growth definition “Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

positive regulation of muscle contraction `http://purl.obolibrary.org/obo/GO_0045933`

Removed

positive regulation of muscle contraction definition “Any process that activates or increases the frequency, rate or extent of muscle contraction.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of muscle contraction definition “Any process that activates or increases the frequency, rate or extent of muscle contraction.”
- database_cross_reference “GOC:curators”

positive regulation of muscle organ development `http://purl.obolibrary.org/obo/GO_0048636`

Removed

positive regulation of muscle organ development definition “Any process that activates, maintains or increases the rate of muscle development.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of muscle organ development definition “Any process that activates, maintains or increases the rate of muscle development.”
- database_cross_reference “GOC:curators”

positive regulation of myeloid cell differentiation `http://purl.obolibrary.org/obo/GO_0045639`

Removed

positive regulation of myeloid cell differentiation definition “Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of myeloid cell differentiation definition “Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of myoblast differentiation `http://purl.obolibrary.org/obo/GO_0045663`

Removed

positive regulation of myoblast differentiation definition “Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “CL:0000056”
- database_cross_reference “GOC:mtg_muscle”

Added

positive regulation of myoblast differentiation definition “Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.”
- database_cross_reference “GOC:curators”
- database_cross_reference “CL:0000056”
- database_cross_reference “GOC:mtg_muscle”

positive regulation of neuron apoptotic process `http://purl.obolibrary.org/obo/GO_0043525`

Removed

positive regulation of neuron apoptotic process definition “Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_apoptosis”

Added

positive regulation of neuron apoptotic process definition “Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_apoptosis”

positive regulation of neuron differentiation `http://purl.obolibrary.org/obo/GO_0045666`

Removed

positive regulation of neuron differentiation definition “Any process that activates or increases the frequency, rate or extent of neuron differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of neuron differentiation definition “Any process that activates or increases the frequency, rate or extent of neuron differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of neutrophil differentiation `http://purl.obolibrary.org/obo/GO_0045660`

Removed

positive regulation of neutrophil differentiation definition “Any process that activates or increases the frequency, rate or extent of neutrophil differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of neutrophil differentiation definition “Any process that activates or increases the frequency, rate or extent of neutrophil differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of nitric oxide biosynthetic process `http://purl.obolibrary.org/obo/GO_0045429`

Removed

positive regulation of nitric oxide biosynthetic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of nitric oxide biosynthetic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.”
- database_cross_reference “GOC:curators”

positive regulation of nitric oxide-cGMP mediated signal transduction `http://purl.obolibrary.org/obo/GO_0141150`

Removed

positive regulation of nitric oxide-cGMP mediated signal transduction SubClassOf obsolete positive regulation of nitric oxide mediated signal transduction

Added

positive regulation of nitric oxide-cGMP mediated signal transduction SubClassOf positive regulation of intracellular signal transduction

positive regulation of nitrogen utilization `http://purl.obolibrary.org/obo/GO_0045848`

Removed

positive regulation of nitrogen utilization definition “Any process that activates or increases the frequency, rate or extent of nitrogen utilization.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of nitrogen utilization definition “Any process that activates or increases the frequency, rate or extent of nitrogen utilization.”
- database_cross_reference “GOC:curators”

positive regulation of nucleoside metabolic process `http://purl.obolibrary.org/obo/GO_0045979`

Removed

positive regulation of nucleoside metabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleosides.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of nucleoside metabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleosides.”
- database_cross_reference “GOC:curators”

positive regulation of nucleotide metabolic process `http://purl.obolibrary.org/obo/GO_0045981`

Removed

positive regulation of nucleotide metabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of nucleotide metabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.”
- database_cross_reference “GOC:curators”

positive regulation of nurse cell apoptotic process `http://purl.obolibrary.org/obo/GO_0045850`

Removed

positive regulation of nurse cell apoptotic process definition “Any process that activates or increases the frequency, rate or extent of nurse cell apoptotic process.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_apoptosis”

Added

positive regulation of nurse cell apoptotic process definition “Any process that activates or increases the frequency, rate or extent of nurse cell apoptotic process.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_apoptosis”

positive regulation of oskar mRNA translation `http://purl.obolibrary.org/obo/GO_0046012`

Removed

positive regulation of oskar mRNA translation definition “Any process that activates or increases the frequency, rate or extent of oskar mRNA translation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of oskar mRNA translation definition “Any process that activates or increases the frequency, rate or extent of oskar mRNA translation.”
- database_cross_reference “GOC:curators”

positive regulation of ossification `http://purl.obolibrary.org/obo/GO_0045778`

Removed

positive regulation of ossification definition “Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of ossification definition “Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.”
- database_cross_reference “GOC:curators”

positive regulation of osteoblast differentiation `http://purl.obolibrary.org/obo/GO_0045669`

Removed

positive regulation of osteoblast differentiation definition “Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of osteoblast differentiation definition “Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of osteoclast differentiation `http://purl.obolibrary.org/obo/GO_0045672`

Removed

positive regulation of osteoclast differentiation definition “Any process that activates or increases the frequency, rate or extent of osteoclast differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of osteoclast differentiation definition “Any process that activates or increases the frequency, rate or extent of osteoclast differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of phosphate metabolic process `http://purl.obolibrary.org/obo/GO_0045937`

Removed

positive regulation of phosphate metabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of phosphate metabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates.”
- database_cross_reference “GOC:curators”

positive regulation of phosphatidylinositol biosynthetic process `http://purl.obolibrary.org/obo/GO_0010513`

Removed

positive regulation of phosphatidylinositol biosynthetic process SubClassOf positive regulation of phospholipid biosynthetic process

Added

positive regulation of phosphorus utilization `http://purl.obolibrary.org/obo/GO_0045949`

Removed

positive regulation of phosphorus utilization definition “Any process that activates or increases the frequency, rate or extent of phosphorus utilization.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of phosphorus utilization definition “Any process that activates or increases the frequency, rate or extent of phosphorus utilization.”
- database_cross_reference “GOC:curators”

positive regulation of photoreceptor cell differentiation `http://purl.obolibrary.org/obo/GO_0046534`

Removed

positive regulation of photoreceptor cell differentiation definition “Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of photoreceptor cell differentiation definition “Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.”
- database_cross_reference “GOC:curators”

positive regulation of pinocytosis `http://purl.obolibrary.org/obo/GO_0048549`

Removed

positive regulation of pinocytosis definition “Any process that activates, maintains or increases the rate of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally ‘cell drinking’. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of pinocytosis definition “Any process that activates, maintains or increases the rate of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally ‘cell drinking’. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes.”
- database_cross_reference “GOC:curators”

positive regulation of plasmatocyte differentiation `http://purl.obolibrary.org/obo/GO_0045615`

Removed

positive regulation of plasmatocyte differentiation definition “Any process that activates or increases the frequency, rate or extent of plasmatocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of plasmatocyte differentiation definition “Any process that activates or increases the frequency, rate or extent of plasmatocyte differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of pole plasm oskar mRNA localization `http://purl.obolibrary.org/obo/GO_0045856`

Removed

positive regulation of pole plasm oskar mRNA localization definition “Any process that activates or increases the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of pole plasm oskar mRNA localization definition “Any process that activates or increases the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm.”
- database_cross_reference “GOC:curators”

positive regulation of preblastoderm mitotic cell cycle `http://purl.obolibrary.org/obo/GO_0046002`

Removed

positive regulation of preblastoderm mitotic cell cycle definition “Any process that activates or increases the rate or extent of progression through the preblastoderm mitotic cell cycle.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

positive regulation of preblastoderm mitotic cell cycle definition “Any process that activates or increases the rate or extent of progression through the preblastoderm mitotic cell cycle.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

positive regulation of protein catabolic process `http://purl.obolibrary.org/obo/GO_0045732`

Removed

positive regulation of protein catabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of protein catabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.”
- database_cross_reference “GOC:curators”

positive regulation of protein kinase activity `http://purl.obolibrary.org/obo/GO_0045860`

Removed

positive regulation of protein kinase activity definition “Any process that activates or increases the frequency, rate or extent of protein kinase activity.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of protein kinase activity definition “Any process that activates or increases the frequency, rate or extent of protein kinase activity.”
- database_cross_reference “GOC:curators”

positive regulation of proteolysis `http://purl.obolibrary.org/obo/GO_0045862`

Removed

positive regulation of proteolysis definition “Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of proteolysis definition “Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.”
- database_cross_reference “GOC:curators”

positive regulation of purine nucleobase metabolic process `http://purl.obolibrary.org/obo/GO_0045983`

Removed

positive regulation of purine nucleobase metabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving purine bases.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of purine nucleobase metabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving purine bases.”
- database_cross_reference “GOC:curators”

positive regulation of purine nucleotide biosynthetic process `http://purl.obolibrary.org/obo/GO_1900373`

Removed

positive regulation of purine nucleotide biosynthetic process definition “Any process that activates or increases the frequency, rate or extent of purine nucleotide biosynthetic processes.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:TermGenie”

Added

positive regulation of purine nucleotide biosynthetic process definition “Any process that activates or increases the frequency, rate or extent of purine nucleotide biosynthetic processes.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:TermGenie”

positive regulation of pyrimidine nucleobase metabolic process `http://purl.obolibrary.org/obo/GO_0045985`

Removed

positive regulation of pyrimidine nucleobase metabolic process has_exact_synonym “positive regulation of pyrimidine base metabolic process”
- database_cross_reference “GOC:go_curators”
positive regulation of pyrimidine nucleobase metabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of pyrimidine nucleobase metabolic process has_exact_synonym “positive regulation of pyrimidine base metabolic process”
- database_cross_reference “GOC:curators”
positive regulation of pyrimidine nucleobase metabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases.”
- database_cross_reference “GOC:curators”

positive regulation of pyruvate decarboxylation to acetyl-CoA `http://purl.obolibrary.org/obo/GO_0140176`

Removed

Added

positive regulation of pyruvate decarboxylation to acetyl-CoA SubClassOf positive regulation of acetyl-CoA biosynthesis

positive regulation of receptor-mediated endocytosis `http://purl.obolibrary.org/obo/GO_0048260`

Removed

positive regulation of receptor-mediated endocytosis definition “Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

positive regulation of receptor-mediated endocytosis definition “Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

positive regulation of salivary gland boundary specification `http://purl.obolibrary.org/obo/GO_0045706`

Removed

positive regulation of salivary gland boundary specification definition “Any process that activates or increases the frequency, rate or extent of salivary gland determination.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

positive regulation of salivary gland boundary specification definition “Any process that activates or increases the frequency, rate or extent of salivary gland determination.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

positive regulation of septation initiation signaling `http://purl.obolibrary.org/obo/GO_0031031`

Removed

positive regulation of septation initiation signaling SubClassOf positive regulation of division septum assembly

positive regulation of sevenless signaling pathway `http://purl.obolibrary.org/obo/GO_0045874`

Removed

positive regulation of sevenless signaling pathway definition “Any process that activates or increases the frequency, rate or extent of the sevenless signaling pathway.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of sevenless signaling pathway definition “Any process that activates or increases the frequency, rate or extent of the sevenless signaling pathway.”
- database_cross_reference “GOC:curators”

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate `http://purl.obolibrary.org/obo/GO_0045870`

Removed

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate definition “Any process that activates or increases the frequency, rate or extent of retroviral genome replication.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate definition “Any process that activates or increases the frequency, rate or extent of retroviral genome replication.”
- database_cross_reference “GOC:curators”

positive regulation of sister chromatid cohesion `http://purl.obolibrary.org/obo/GO_0045876`

Removed

positive regulation of sister chromatid cohesion definition “Any process that activates or increases the frequency, rate or extent of sister chromatid cohesion.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of sister chromatid cohesion definition “Any process that activates or increases the frequency, rate or extent of sister chromatid cohesion.”
- database_cross_reference “GOC:curators”

positive regulation of skeletal muscle tissue development `http://purl.obolibrary.org/obo/GO_0048643`

Removed

positive regulation of skeletal muscle tissue development definition “Any process that activates, maintains or increases the rate of skeletal muscle tissue development.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of skeletal muscle tissue development definition “Any process that activates, maintains or increases the rate of skeletal muscle tissue development.”
- database_cross_reference “GOC:curators”

positive regulation of small molecule metabolic process `http://purl.obolibrary.org/obo/GO_0062013`

Added

positive regulation of small molecule metabolic process in_subset gocheck_do_not_annotate
positive regulation of small molecule metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31485”^^anyURI

positive regulation of smooth muscle contraction `http://purl.obolibrary.org/obo/GO_0045987`

Removed

positive regulation of smooth muscle contraction definition “Any process that activates or increases the frequency, rate or extent of smooth muscle contraction.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of smooth muscle contraction definition “Any process that activates or increases the frequency, rate or extent of smooth muscle contraction.”
- database_cross_reference “GOC:curators”

positive regulation of smoothened signaling pathway `http://purl.obolibrary.org/obo/GO_0045880`

Removed

positive regulation of smoothened signaling pathway definition “Any process that activates or increases the frequency, rate or extent of smoothened signaling.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of smoothened signaling pathway definition “Any process that activates or increases the frequency, rate or extent of smoothened signaling.”
- database_cross_reference “GOC:curators”

positive regulation of spermatid nuclear differentiation `http://purl.obolibrary.org/obo/GO_0045702`

Removed

positive regulation of spermatid nuclear differentiation definition “Any process that activates or increases the frequency, rate or extent of spermatid nuclear differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of spermatid nuclear differentiation definition “Any process that activates or increases the frequency, rate or extent of spermatid nuclear differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of sporulation resulting in formation of a cellular spore `http://purl.obolibrary.org/obo/GO_0045881`

Removed

positive regulation of sporulation resulting in formation of a cellular spore definition “Any process that activates or increases the frequency, rate or extent of sporulation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of sporulation resulting in formation of a cellular spore definition “Any process that activates or increases the frequency, rate or extent of sporulation.”
- database_cross_reference “GOC:curators”

positive regulation of steroid metabolic process `http://purl.obolibrary.org/obo/GO_0045940`

Removed

positive regulation of steroid metabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of steroid metabolic process definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids.”
- database_cross_reference “GOC:curators”

positive regulation of striated muscle contraction `http://purl.obolibrary.org/obo/GO_0045989`

Removed

positive regulation of striated muscle contraction definition “Any process that activates or increases the frequency, rate or extent of striated muscle contraction.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of striated muscle contraction definition “Any process that activates or increases the frequency, rate or extent of striated muscle contraction.”
- database_cross_reference “GOC:curators”

positive regulation of striated muscle tissue development `http://purl.obolibrary.org/obo/GO_0045844`

Removed

positive regulation of striated muscle tissue development definition “Any process that activates or increases the frequency, rate or extent of striated muscle development.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of striated muscle tissue development definition “Any process that activates or increases the frequency, rate or extent of striated muscle development.”
- database_cross_reference “GOC:curators”

positive regulation of sulfur utilization `http://purl.obolibrary.org/obo/GO_0045883`

Removed

positive regulation of sulfur utilization definition “Any process that activates or increases the frequency, rate or extent of sulfur utilization.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of sulfur utilization definition “Any process that activates or increases the frequency, rate or extent of sulfur utilization.”
- database_cross_reference “GOC:curators”

positive regulation of synaptic assembly at neuromuscular junction `http://purl.obolibrary.org/obo/GO_0045887`

Removed

positive regulation of synaptic assembly at neuromuscular junction definition “Any process that activates or increases the frequency, rate or extent of synaptic assembly at neuromuscular junction.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of synaptic assembly at neuromuscular junction definition “Any process that activates or increases the frequency, rate or extent of synaptic assembly at neuromuscular junction.”
- database_cross_reference “GOC:curators”

positive regulation of syncytial blastoderm mitotic cell cycle `http://purl.obolibrary.org/obo/GO_0046004`

Removed

positive regulation of syncytial blastoderm mitotic cell cycle definition “Any process that activates or increases the rate or extent of progression through the syncytial blastoderm mitotic cell cycle.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

positive regulation of syncytial blastoderm mitotic cell cycle definition “Any process that activates or increases the rate or extent of progression through the syncytial blastoderm mitotic cell cycle.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

positive regulation of syncytium formation by plasma membrane fusion `http://purl.obolibrary.org/obo/GO_0060143`

Removed

positive regulation of syncytium formation by plasma membrane fusion SubClassOf positive regulation of developmental process

positive regulation of synergid differentiation `http://purl.obolibrary.org/obo/GO_0045699`

Removed

positive regulation of synergid differentiation definition “Any process that activates or increases the frequency, rate or extent of synergid cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of synergid differentiation definition “Any process that activates or increases the frequency, rate or extent of synergid cell differentiation.”
- database_cross_reference “GOC:curators”

positive regulation of terreate biosynthetic process `http://purl.obolibrary.org/obo/GO_0180069`

Added

positive regulation of terreate biosynthetic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of terreate.”
- database_cross_reference “PMID:25265334”
positive regulation of terreate biosynthetic process created by “PomBase:vw”
positive regulation of terreate biosynthetic process id “GO:0180069”
positive regulation of terreate biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31114”^^anyURI
positive regulation of terreate biosynthetic process creation date “2026-02-23T15:24:17Z”
positive regulation of terreate biosynthetic process has_obo_namespace “biological_process”
positive regulation of terreate biosynthetic process label “positive regulation of terreate biosynthetic process”
Class: positive regulation of terreate biosynthetic process
positive regulation of terreate biosynthetic process EquivalentTo biological regulation and (positively regulates some terreate biosynthetic process)
positive regulation of terreate biosynthetic process SubClassOf positively regulates some terreate biosynthetic process
positive regulation of terreate biosynthetic process SubClassOf regulation of ketone biosynthetic process
positive regulation of terreate biosynthetic process SubClassOf positive regulation of alcohol biosynthetic process

positive regulation of transcription by RNA polymerase I `http://purl.obolibrary.org/obo/GO_0045943`

Removed

positive regulation of transcription by RNA polymerase I definition “Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:txnOH”

Added

positive regulation of transcription by RNA polymerase I definition “Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:txnOH”

positive regulation of transcription by RNA polymerase II `http://purl.obolibrary.org/obo/GO_0045944`

Removed

positive regulation of transcription by RNA polymerase II definition “Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:txnOH”

Added

positive regulation of transcription by RNA polymerase II definition “Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:txnOH”

positive regulation of transcription by RNA polymerase III `http://purl.obolibrary.org/obo/GO_0045945`

Removed

positive regulation of transcription by RNA polymerase III definition “Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase III.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:txnOH”

Added

positive regulation of transcription by RNA polymerase III definition “Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase III.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:txnOH”

positive regulation of transcription by galactose `http://purl.obolibrary.org/obo/GO_0000411`

Removed

positive regulation of transcription by galactose definition “Any process involving galactose that activates or increases the rate of transcription.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of transcription by galactose definition “Any process involving galactose that activates or increases the rate of transcription.”
- database_cross_reference “GOC:curators”

positive regulation of transcription by glucose `http://purl.obolibrary.org/obo/GO_0046016`

Removed

positive regulation of transcription by glucose definition “Any process involving glucose that activates or increases the rate of transcription.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of transcription by glucose definition “Any process involving glucose that activates or increases the rate of transcription.”
- database_cross_reference “GOC:curators”

positive regulation of transforming growth factor beta receptor signaling pathway `http://purl.obolibrary.org/obo/GO_0030511`

Removed

positive regulation of transforming growth factor beta receptor signaling pathway definition “Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of transforming growth factor beta receptor signaling pathway definition “Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity.”
- database_cross_reference “GOC:curators”

positive regulation of translation `http://purl.obolibrary.org/obo/GO_0045727`

Removed

positive regulation of translation definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

positive regulation of translation definition “Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

positive regulation of translation, ncRNA-mediated `http://purl.obolibrary.org/obo/GO_0045975`

Removed

positive regulation of translation, ncRNA-mediated definition “Any process, mediated by small non-coding RNAs, that activates or increases the rate that mRNAs are effectively translated into protein.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

positive regulation of translation, ncRNA-mediated definition “Any process, mediated by small non-coding RNAs, that activates or increases the rate that mRNAs are effectively translated into protein.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

positive regulation of translational elongation `http://purl.obolibrary.org/obo/GO_0045901`

Removed

positive regulation of translational elongation definition “Any process that activates or increases the frequency, rate or extent of translational elongation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of translational elongation definition “Any process that activates or increases the frequency, rate or extent of translational elongation.”
- database_cross_reference “GOC:curators”

positive regulation of translational initiation `http://purl.obolibrary.org/obo/GO_0045948`

Removed

positive regulation of translational initiation definition “Any process that activates or increases the frequency, rate or extent of translational initiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of translational initiation definition “Any process that activates or increases the frequency, rate or extent of translational initiation.”
- database_cross_reference “GOC:curators”

positive regulation of translational initiation by iron `http://purl.obolibrary.org/obo/GO_0045994`

Removed

positive regulation of translational initiation by iron definition “Any process involving iron that activates or increases the rate of translational initiation.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of translational initiation by iron definition “Any process involving iron that activates or increases the rate of translational initiation.”
- database_cross_reference “GOC:curators”

positive regulation of translational termination `http://purl.obolibrary.org/obo/GO_0045905`

Removed

positive regulation of translational termination definition “Any process that activates or increases the frequency, rate or extent of translational termination.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of translational termination definition “Any process that activates or increases the frequency, rate or extent of translational termination.”
- database_cross_reference “GOC:curators”

positive regulation of uterine smooth muscle contraction `http://purl.obolibrary.org/obo/GO_0070474`

Removed

positive regulation of uterine smooth muscle contraction definition “Any process that increases the frequency, rate or extent of uterine smooth muscle contraction.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of uterine smooth muscle contraction definition “Any process that increases the frequency, rate or extent of uterine smooth muscle contraction.”
- database_cross_reference “GOC:curators”

positive regulation of vasoconstriction `http://purl.obolibrary.org/obo/GO_0045907`

Removed

positive regulation of vasoconstriction definition “Any process that activates or increases the frequency, rate or extent of vasoconstriction.”
- database_cross_reference “GOC:go_curators”

Added

positive regulation of vasoconstriction definition “Any process that activates or increases the frequency, rate or extent of vasoconstriction.”
- database_cross_reference “GOC:curators”

post-embryonic animal morphogenesis `http://purl.obolibrary.org/obo/GO_0009886`

Removed

post-embryonic animal morphogenesis definition “The process, occurring after animal embryonic development, by which anatomical structures are generated and organized.”
- database_cross_reference “GOC:go_curators”

Added

post-embryonic animal morphogenesis definition “The process, occurring after animal embryonic development, by which anatomical structures are generated and organized.”
- database_cross_reference “GOC:curators”

post-embryonic development `http://purl.obolibrary.org/obo/GO_0009791`

Removed

post-embryonic development definition “The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.”
- database_cross_reference “GOC:go_curators”

Added

post-embryonic development definition “The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.”
- database_cross_reference “GOC:curators”

posterior midgut development `http://purl.obolibrary.org/obo/GO_0007497`

Removed

posterior midgut development definition “The process whose specific outcome is the progression of the posterior midgut over time, from its formation to the mature structure.”
- database_cross_reference “GOC:go_curators”

Added

posterior midgut development definition “The process whose specific outcome is the progression of the posterior midgut over time, from its formation to the mature structure.”
- database_cross_reference “GOC:curators”

potassium channel activator activity `http://purl.obolibrary.org/obo/GO_0099104`

Added

potassium channel activator activity database_cross_reference “Reactome:R-HSA-400063”
- label “Low conductance potassium channels in pancreatic beta cells open in response to epinephrine”

potassium channel inhibitor activity `http://purl.obolibrary.org/obo/GO_0019870`

Added

potassium channel inhibitor activity database_cross_reference “Reactome:R-HSA-381713”
- label “Potassium voltage-gated channels close in reponse to PKA”
potassium channel inhibitor activity database_cross_reference “Reactome:R-HSA-381644”
- label “ER calcium channels open in response to activated PKA”

prenol biosynthetic process `http://purl.obolibrary.org/obo/GO_0016091`

Removed

prenol biosynthetic process definition “The chemical reactions and pathways resulting in the formation of prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail.”
- database_cross_reference “GOC:go_curators”

Added

prenol biosynthetic process definition “The chemical reactions and pathways resulting in the formation of prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail.”
- database_cross_reference “GOC:curators”

prenol catabolic process `http://purl.obolibrary.org/obo/GO_0016092`

Removed

prenol catabolic process definition “The chemical reactions and pathways resulting in the breakdown of prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail.”
- database_cross_reference “GOC:go_curators”

Added

prenol catabolic process definition “The chemical reactions and pathways resulting in the breakdown of prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail.”
- database_cross_reference “GOC:curators”

prenyl-FMNH2 biosynthetic process `http://purl.obolibrary.org/obo/GO_0120232`

Added

prenyl-FMNH2 biosynthetic process database_cross_reference “MetaCyc:PWY0-1597”
prenyl-FMNH2 biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI

prenylcysteine oxidase activity `http://purl.obolibrary.org/obo/GO_0001735`

Added

prenylcysteine oxidase activity narrowMatch 70407
prenylcysteine oxidase activity database_cross_reference “RHEA:70407”

primary cell wall `http://purl.obolibrary.org/obo/GO_0009530`

Removed

primary cell wall definition “A plant cell wall that is still able to expand, permitting cell growth. Primary cell walls contain more pectin than secondary walls and no lignin is present.”
- database_cross_reference “GOC:jid”
- database_cross_reference “PMID:9442872”

Added

primary cell wall definition “A plant cell wall that is still able to expand, permitting cell growth. Primary cell walls contain more pectin than secondary walls and no lignin is present.”
- database_cross_reference “GOC:jid”
- database_cross_reference “PMID:9442872”
- database_cross_reference “PMID:39878232”

primary metabolic process `http://purl.obolibrary.org/obo/GO_0044238`

Removed

primary metabolic process definition “The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.”
- database_cross_reference “GOC:go_curators”

Added

primary metabolic process definition “The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.”
- database_cross_reference “GOC:curators”
primary metabolic process database_cross_reference “Reactome:R-HSA-71291”
- label “Metabolism of amino acids and derivatives”

primary methylamine oxidase activity `http://purl.obolibrary.org/obo/GO_0008131`

Added

primary methylamine oxidase activity database_cross_reference “RHEA:69148”
primary methylamine oxidase activity database_cross_reference “RHEA:25265”
primary methylamine oxidase activity database_cross_reference “RHEA:35107”
primary methylamine oxidase activity database_cross_reference “RHEA:59600”
primary methylamine oxidase activity narrowMatch 69136
primary methylamine oxidase activity narrowMatch 59416
primary methylamine oxidase activity narrowMatch 35107
primary methylamine oxidase activity database_cross_reference “RHEA:59420”
primary methylamine oxidase activity database_cross_reference “RHEA:69076”
primary methylamine oxidase activity narrowMatch 71015
primary methylamine oxidase activity narrowMatch 59424
primary methylamine oxidase activity database_cross_reference “RHEA:69072”
primary methylamine oxidase activity narrowMatch 25265
primary methylamine oxidase activity narrowMatch 70283
primary methylamine oxidase activity database_cross_reference “RHEA:59416”
primary methylamine oxidase activity narrowMatch 59596
primary methylamine oxidase activity narrowMatch 69076
primary methylamine oxidase activity database_cross_reference “RHEA:30591”
primary methylamine oxidase activity narrowMatch 69148
primary methylamine oxidase activity narrowMatch 30591
primary methylamine oxidase activity database_cross_reference “RHEA:70283”
primary methylamine oxidase activity narrowMatch 69072
primary methylamine oxidase activity narrowMatch 27946
primary methylamine oxidase activity database_cross_reference “RHEA:59596”
primary methylamine oxidase activity database_cross_reference “RHEA:69144”
primary methylamine oxidase activity database_cross_reference “RHEA:27946”
primary methylamine oxidase activity narrowMatch 78367
primary methylamine oxidase activity database_cross_reference “RHEA:69136”
primary methylamine oxidase activity narrowMatch 69132
primary methylamine oxidase activity database_cross_reference “RHEA:71015”
primary methylamine oxidase activity database_cross_reference “RHEA:59424”
primary methylamine oxidase activity narrowMatch 59600
primary methylamine oxidase activity narrowMatch 69144
primary methylamine oxidase activity narrowMatch 59420
primary methylamine oxidase activity database_cross_reference “RHEA:78367”
primary methylamine oxidase activity database_cross_reference “RHEA:59604”
primary methylamine oxidase activity database_cross_reference “RHEA:69132”
primary methylamine oxidase activity narrowMatch 59604

pristanate-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0070251`

Removed

pristanate-CoA ligase activity SubClassOf acid-thiol ligase activity

progesterone 11-alpha-monooxygenase activity `http://purl.obolibrary.org/obo/GO_0050212`

Removed

progesterone 11-alpha-monooxygenase activity has_related_synonym “progesterone 11alpha-hydroxylase activity”
- database_cross_reference “EC:1.14.99.14”
progesterone 11-alpha-monooxygenase activity has_related_synonym “progesterone 11alpha-monooxygenase activity”
- database_cross_reference “EC:1.14.99.14”
progesterone 11-alpha-monooxygenase activity definition “Catalysis of the reaction: AH2 + O2 + progesterone = 11alpha-hydroxyprogesterone + A + H2O.”
- database_cross_reference “RHEA:18205”
progesterone 11-alpha-monooxygenase activity has_related_synonym “progesterone 11-alpha-hydroxylase activity”
- database_cross_reference “EC:1.14.99.14”
progesterone 11-alpha-monooxygenase activity exactMatch 1.14.99.14
progesterone 11-alpha-monooxygenase activity database_cross_reference “PMID:39766209”
progesterone 11-alpha-monooxygenase activity exactMatch 18205
progesterone 11-alpha-monooxygenase activity database_cross_reference “EC:1.14.99.14”
progesterone 11-alpha-monooxygenase activity has_related_synonym “progesterone,hydrogen-donor:oxygen oxidoreductase (11alpha-hydroxylating)”
- database_cross_reference “EC:1.14.99.14”
progesterone 11-alpha-monooxygenase activity database_cross_reference “RHEA:18205”

Added

progesterone 11-alpha-monooxygenase activity has_related_synonym “progesterone,hydrogen-donor:oxygen oxidoreductase (11alpha-hydroxylating)”
- database_cross_reference “EC:1.14.14.197”
progesterone 11-alpha-monooxygenase activity has_related_synonym “progesterone 11-alpha-hydroxylase activity”
- database_cross_reference “EC:1.14.14.197”
progesterone 11-alpha-monooxygenase activity has_related_synonym “progesterone 11alpha-hydroxylase activity”
- database_cross_reference “EC:1.14.14.197”
progesterone 11-alpha-monooxygenase activity database_cross_reference “RHEA:86055”
progesterone 11-alpha-monooxygenase activity exactMatch 86055
progesterone 11-alpha-monooxygenase activity has_related_synonym “progesterone 11alpha-monooxygenase activity”
- database_cross_reference “EC:1.14.14.197”
progesterone 11-alpha-monooxygenase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31423”^^anyURI
progesterone 11-alpha-monooxygenase activity definition “Catalysis of the reaction: progesterone + reduced [NADPH-hemoprotein reductase] + O2 = 11alpha-hydroxyprogesterone + oxidized [NADPH-hemoprotein reductase] + H2O + H+.”
- database_cross_reference “RHEA:86055”
- database_cross_reference “PMID:39766209”

proline dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0004657`

Removed

proline dehydrogenase activity database_cross_reference “Reactome:R-HSA-8955817”
- label “PRODH2 oxidises HPRO to 1PYR-5COOH”
proline dehydrogenase activity database_cross_reference “Reactome:R-HSA-70670”
- label “PRODH oxidises L-Pro to 1PYR-5COOH”

Added

proline dehydrogenase activity database_cross_reference “Reactome:R-HSA-8955817”
- label “PRODH2 oxidises HPRO to 1PYR-3OH-5COOH”

propionate biosynthetic process `http://purl.obolibrary.org/obo/GO_0019542`

Removed

propionate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of propionate, the anion derived from propionic acid.”
- database_cross_reference “GOC:go_curators”

Added

propionate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of propionate, the anion derived from propionic acid.”
- database_cross_reference “GOC:curators”

propionate catabolic process `http://purl.obolibrary.org/obo/GO_0019543`

Removed

propionate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of propionate, the anion derived from propionic acid.”
- database_cross_reference “GOC:go_curators”

Added

propionate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31668”^^anyURI
propionate catabolic process database_cross_reference “MetaCyc:PWY0-42”
propionate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of propionate, the anion derived from propionic acid.”
- database_cross_reference “GOC:curators”
propionate catabolic process narrowMatch PWY-5747
propionate catabolic process narrowMatch PWY0-42
propionate catabolic process database_cross_reference “MetaCyc:PWY-5747”

propionate metabolic process `http://purl.obolibrary.org/obo/GO_0019541`

Removed

propionate metabolic process definition “The chemical reactions and pathways involving propionate, the anion derived from propionic (propanoic) acid, a carboxylic acid important in the energy metabolism of ruminants.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

propionate metabolic process definition “The chemical reactions and pathways involving propionate, the anion derived from propionic (propanoic) acid, a carboxylic acid important in the energy metabolism of ruminants.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

propionyl-CoA catabolic process `http://purl.obolibrary.org/obo/GO_1902859`

Added

propionyl-CoA catabolic process database_cross_reference “MetaCyc:PROPIONMET-PWY”
propionyl-CoA catabolic process narrowMatch PROPIONMET-PWY
propionyl-CoA catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31668”^^anyURI
propionyl-CoA catabolic process narrowMatch PWY-7574
propionyl-CoA catabolic process database_cross_reference “MetaCyc:PWY-7574”

proteasomal ubiquitin-independent protein catabolic process `http://purl.obolibrary.org/obo/GO_0010499`

Added

proteasomal ubiquitin-independent protein catabolic process database_cross_reference “Reactome:R-HSA-9912633”
- label “Antigen processing: Ub, ATP-independent proteasomal degradation”

proteasome assembly `http://purl.obolibrary.org/obo/GO_0043248`

Removed

proteasome assembly definition “The aggregation, arrangement and bonding together of a mature, active proteasome complex.”
- database_cross_reference “PMID:10872471”
- database_cross_reference “GOC:go_curators”

Added

proteasome assembly definition “The aggregation, arrangement and bonding together of a mature, active proteasome complex.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:10872471”

proteasome core complex, alpha-subunit complex `http://purl.obolibrary.org/obo/GO_0019773`

Removed

proteasome core complex, alpha-subunit complex SubClassOf protein-containing complex
proteasome core complex, alpha-subunit complex SubClassOf part of some intracellular anatomical structure

Added

proteasome core complex, alpha-subunit complex SubClassOf intracellular protein-containing complex

proteasome-mediated ubiquitin-dependent protein catabolic process `http://purl.obolibrary.org/obo/GO_0043161`

Removed

proteasome-mediated ubiquitin-dependent protein catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.”
- database_cross_reference “GOC:go_curators”

Added

proteasome-mediated ubiquitin-dependent protein catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.”
- database_cross_reference “GOC:curators”

protein N-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0140186`

Added

protein N-acyltransferase activity database_cross_reference “RHEA:59796”
protein N-acyltransferase activity database_cross_reference “RHEA:83531”
protein N-acyltransferase activity database_cross_reference “RHEA:59764”
protein N-acyltransferase activity narrowMatch 59796
protein N-acyltransferase activity database_cross_reference “RHEA:59800”
protein N-acyltransferase activity narrowMatch 85279
protein N-acyltransferase activity database_cross_reference “RHEA:85279”
protein N-acyltransferase activity narrowMatch 83531
protein N-acyltransferase activity narrowMatch 59764
protein N-acyltransferase activity narrowMatch 59800

protein N-linked glycosylation `http://purl.obolibrary.org/obo/GO_0006487`

Added

protein N-linked glycosylation database_cross_reference “Reactome:R-HSA-480985”
- label “Synthesis of dolichyl-phosphate-glucose”
protein N-linked glycosylation database_cross_reference “Reactome:R-HSA-446203”
- label “Asparagine N-linked glycosylation”

protein N-terminal-methionine acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0120518`

Added

protein N-terminal-serine acetyltransferase activity `http://purl.obolibrary.org/obo/GO_1990189`

Added

protein O-acetylglucosaminyltransferase activity `http://purl.obolibrary.org/obo/GO_0097363`

Added

protein O-acetylglucosaminyltransferase activity database_cross_reference “Reactome:R-HSA-8879117”
- label “POMGNT2 transfers GlcNAc to Man-DAG1”

protein acylation `http://purl.obolibrary.org/obo/GO_0043543`

Removed

protein acylation in_subset goslim_yeast

protein alkylation `http://purl.obolibrary.org/obo/GO_0008213`

Removed

protein alkylation in_subset goslim_yeast

protein binding `http://purl.obolibrary.org/obo/GO_0005515`

Removed

protein binding definition “Binding to a protein.”
- database_cross_reference “GOC:go_curators”

Added

protein binding definition “Binding to a protein.”
- database_cross_reference “GOC:curators”

protein carrier activity `http://purl.obolibrary.org/obo/GO_0140597`

Removed

protein carrier activity definition “Binding to and carrying a protein between two different cellular components by moving along with the target protein.”
- database_cross_reference “PMID:7628437”
protein carrier activity has_exact_synonym “protein carrier activity”
protein carrier activity label “protein carrier chaperone”
protein carrier activity SubClassOf has part some protein binding

Added

protein carrier activity label “protein carrier activity”
protein carrier activity term tracker item “https://github.com/geneontology/go-ontology/issues/31601”^^anyURI
protein carrier activity definition “Binding to and carrying a protein to an acceptor molecule or to a specific location by moving along with the target protein.”
- database_cross_reference “PMID:7628437”
protein carrier activity has_exact_synonym “protein carrier chaperone”

protein catabolic process `http://purl.obolibrary.org/obo/GO_0030163`

Added

protein catabolic process in_subset goslim_yeast

protein complex scaffold activity `http://purl.obolibrary.org/obo/GO_0140378`

Added

protein complex scaffold activity created by “pg”
protein complex scaffold activity has_exact_synonym “protein-complex scaffolding activity”
protein complex scaffold activity creation date “2026-02-02T08:05:02Z”
protein complex scaffold activity label “protein complex scaffold activity”
protein complex scaffold activity term tracker item “https://github.com/geneontology/go-ontology/issues/31444”^^anyURI
protein complex scaffold activity has_exact_synonym “protein-containing complex scaffold activity”
protein complex scaffold activity has_obo_namespace “molecular_function”
protein complex scaffold activity definition “A structural molecule activity of a protein-containing complex component that serves to hold the complex together. Protein complex scaffolds are integral members of complexes.”
- database_cross_reference “PMID:41298522”
protein complex scaffold activity id “GO:0140378”
Class: protein complex scaffold activity
protein complex scaffold activity SubClassOf structural molecule activity

protein dephosphorylation `http://purl.obolibrary.org/obo/GO_0006470`

Removed

protein dephosphorylation in_subset goslim_yeast

protein digestion `http://purl.obolibrary.org/obo/GO_0044256`

Removed

protein digestion definition “The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested proteins into components that may be easily absorbed and directed into metabolism.”
- database_cross_reference “GOC:go_curators”

Added

protein digestion definition “The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested proteins into components that may be easily absorbed and directed into metabolism.”
- database_cross_reference “GOC:curators”

protein disulfide isomerase activity `http://purl.obolibrary.org/obo/GO_0003756`

Added

protein disulfide isomerase activity database_cross_reference “Reactome:R-HSA-9760559”
- label “DsbA catalyzes disulfide crosslink formation on STa”

protein domain specific binding `http://purl.obolibrary.org/obo/GO_0019904`

Removed

protein domain specific binding definition “Binding to a specific domain of a protein.”
- database_cross_reference “GOC:go_curators”

Added

protein domain specific binding definition “Binding to a specific domain of a protein.”
- database_cross_reference “GOC:curators”

protein farnesyltransferase activity `http://purl.obolibrary.org/obo/GO_0004660`

Added

protein farnesyltransferase activity database_cross_reference “Reactome:R-HSA-9948016”
- label “FNTA:FNTB transfers farnesyl to GBP1”

protein folding `http://purl.obolibrary.org/obo/GO_0006457`

Removed

protein folding definition “The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:rb”

Added

protein folding database_cross_reference “Reactome:R-HSA-390450”
- label “Folding of actin by CCT/TriC”
protein folding definition “The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:rb”

protein folding chaperone `http://purl.obolibrary.org/obo/GO_0044183`

Added

protein folding chaperone comment “Note that a protein folding chaperone binds an unfolded protein to fold it. Do not confuse with unfolded protein holdase activity, which binds an unfolded protein and keeps it unfolded to deliver it to its final destination.”
protein folding chaperone term tracker item “https://github.com/geneontology/go-ontology/issues/30552”^^anyURI

protein heterotetramerization `http://purl.obolibrary.org/obo/GO_0051290`

Removed

protein heterotetramerization definition “The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical.”
- database_cross_reference “GOC:go_curators”

Added

protein heterotetramerization definition “The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical.”
- database_cross_reference “GOC:curators”

protein homotetramerization `http://purl.obolibrary.org/obo/GO_0051289`

Removed

protein homotetramerization definition “The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.”
- database_cross_reference “GOC:go_curators”

Added

protein homotetramerization definition “The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.”
- database_cross_reference “GOC:curators”

protein import into mitochondrial intermembrane space `http://purl.obolibrary.org/obo/GO_0045041`

Added

protein import into mitochondrial intermembrane space SubClassOf intercellular transport

protein import into mitochondrial matrix `http://purl.obolibrary.org/obo/GO_0030150`

Added

protein import into mitochondrial matrix SubClassOf intercellular transport

protein kinase activity `http://purl.obolibrary.org/obo/GO_0004672`

Added

protein kinase activity database_cross_reference “Reactome:R-HSA-5693148”
- label “BCKDK phosphorylates BCKDH”

protein lipidation `http://purl.obolibrary.org/obo/GO_0006497`

Removed

protein lipidation in_subset goslim_yeast

protein localization to cell wall `http://purl.obolibrary.org/obo/GO_0099613`

Removed

protein localization to cell wall SubClassOf protein localization to cell periphery

Added

protein localization to cell wall SubClassOf intracellular protein localization
protein localization to cell wall SubClassOf protein localization to extracellular region

protein localization to outer membrane `http://purl.obolibrary.org/obo/GO_0089705`

Removed

protein localization to outer membrane SubClassOf protein localization to cell periphery

Added

protein localization to outer membrane SubClassOf protein localization to extracellular region

protein localization to spore cell wall `http://purl.obolibrary.org/obo/GO_0099614`

Removed

protein localization to spore cell wall SubClassOf protein localization to cell periphery

Added

protein lysine deacetylase activity `http://purl.obolibrary.org/obo/GO_0033558`

Added

protein lysine deacetylase activity database_cross_reference “RHEA:21548”
protein lysine deacetylase activity narrowMatch 21548

protein maturation `http://purl.obolibrary.org/obo/GO_0051604`

Added

protein maturation database_cross_reference “Reactome:R-HSA-9918432”
- label “Maturation of DENV proteins”

protein methylesterase activity `http://purl.obolibrary.org/obo/GO_0051723`

Added

protein methylesterase activity database_cross_reference “Reactome:R-HSA-8856951”
- label “PP2A demethylation by PPME1”

protein phosphorylated amino acid binding `http://purl.obolibrary.org/obo/GO_0045309`

Removed

protein phosphorylated amino acid binding definition “Binding to a phosphorylated amino acid residue within a protein.”
- database_cross_reference “GOC:go_curators”

Added

protein phosphorylated amino acid binding definition “Binding to a phosphorylated amino acid residue within a protein.”
- database_cross_reference “GOC:curators”

protein phosphorylation `http://purl.obolibrary.org/obo/GO_0006468`

Removed

protein phosphorylation in_subset goslim_yeast

protein processing `http://purl.obolibrary.org/obo/GO_0016485`

Added

protein processing database_cross_reference “Reactome:R-HSA-159782”
- label “Removal of aminoterminal propeptides from gamma-carboxylated proteins”

protein sequestering activity `http://purl.obolibrary.org/obo/GO_0140311`

Added

protein sequestering activity database_cross_reference “Reactome:R-HSA-1678694”
- label “Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans”

protein serine kinase activity `http://purl.obolibrary.org/obo/GO_0106310`

Added

protein serine kinase activity narrowMatch 15881
protein serine kinase activity database_cross_reference “Reactome:R-HSA-9948087”
- label “CAMK2 complex phosphorylates VIM:NS4A”
protein serine kinase activity database_cross_reference “RHEA:46600”
protein serine kinase activity narrowMatch 46600
protein serine kinase activity database_cross_reference “RHEA:15881”

protein serine/threonine kinase activator activity `http://purl.obolibrary.org/obo/GO_0043539`

Removed

protein serine/threonine kinase activator activity definition “Binds to and increases the activity of a protein serine/threonine kinase.”
- database_cross_reference “GOC:go_curators”

Added

protein serine/threonine kinase activator activity definition “Binds to and increases the activity of a protein serine/threonine kinase.”
- database_cross_reference “GOC:curators”

protein serine/threonine kinase activity `http://purl.obolibrary.org/obo/GO_0004674`

Removed

protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-170076”
- label “CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-170087”
- label “CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-69604”
- label “Phosphorylation of Cdc25A at Ser-123 by Chk1”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-69608”
- label “Phosphorylation of Cdc25A at Ser-123 by Chk2”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-170116”
- label “Myt-1 mediated phosphorylation of Cyclin A:Cdc2”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-400382”
- label “CSNK1E,CSNK1D phosphorylate CRY and PER proteins”

Added

protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9909369”
- label “CSNK1E,CSNK1D phosphorylate CRY and PER proteins”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9922273”
- label “CSNK1D,E phosphorylates CLOCK in p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-538-BMAL:p-2T,3S-CLOCK:target gene”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-5671749”
- label “p-T774-PKN1 phosphorylates CDC25C”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9857661”
- label “p-T308,S473-AKT1 (phospho-PKB) phosphorylates GJA1 (Connexin-43)”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9929360”
- label “GSK3B phosphorylates CD274”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9912401”
- label “CK2alpha phosphorylates BMAL1 (ARNTL) on serine-90”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9857673”
- label “p-T308,S473-AKT1 phosphorylates ITGA5 (Integrin alpha5) in ITGA5:ITGB1 (Integrin alpha5:Integrin beta1)”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9765960”
- label “ERKs phosphorylate MCRIP1”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9931418”
- label “CK2 phosphorylates CD274”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9943736”
- label “Casein kinase I phosphorylates CDC25A”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-170116”
- label “PKMYT1 phosphorylates CCNA:CDK1”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9021357”
- label “PRKCI phosphorylates ELF3”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9931292”
- label “AMPK phosphorylates CD274”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9943676”
- label “NEK11 phosphorylates CDC25A”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9796053”
- label “PRKCI phosphorylates NFE2L2”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9632858”
- label “PRKCZ autophosphorylates downstream of estrogen stimulation”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-5625784”
- label “PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9912396”
- label “CDK5 phosphorylates CLOCK on serine-451 and serine-461”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9943678”
- label “CHEK1 phosphorylates CHEK2-phosphorylated CDC25A”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9943687”
- label “PLK3 phosphorylates CDC25A”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-193703”
- label “IKKbeta is activated”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9942578”
- label “Phosphorylation of CDC25A by p38 MAPK”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9931409”
- label “NEK2 phosphorylates CD274”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9954237”
- label “PIM1 phosphorylates GBP1”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-170076”
- label “CAK phosphorylates CDK1 bound to CCNB1”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9943675”
- label “GSK3B phosphorylates CDC25A”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-69608”
- label “Phosphorylation of CDC25A by CHEK2”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-5623667”
- label “PDPK1 phosphorylates PKN1,2,3”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-69604”
- label “Phosphorylation of CDC25A by CHEK1”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9933380”
- label “Cytosolic tail of CDH1 is phosphorylated”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9920673”
- label “CDK5 phosphorylates PER2 on serine-396”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-927889”
- label “SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9943662”
- label “CHEK1 phosphorylates NEK11”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-170087”
- label “CAK phosphorylates CDK1 bound to CCNA”
protein serine/threonine kinase activity database_cross_reference “Reactome:R-HSA-9926483”
- label “MARK3 phosphorylates MITF-M on S173”

protein serine/threonine phosphatase activity `http://purl.obolibrary.org/obo/GO_0004722`

Removed

protein serine/threonine phosphatase activity database_cross_reference “Reactome:R-HSA-5693153”
- label “PPM1K dephosphorylates p-BCKDH”
protein serine/threonine phosphatase activity database_cross_reference “Reactome:R-HSA-163750”
- label “Dephosphorylation of phosphoPFKFB1 by PP2A complex”
protein serine/threonine phosphatase activity database_cross_reference “Reactome:R-HSA-163689”
- label “Dephosphorylation of pChREBP (Ser 196) by PP2A”

Added

protein serine/threonine phosphatase activity database_cross_reference “Reactome:R-HSA-9970190”
- label “PP1 dephosphorylates RNA Pol II”
protein serine/threonine phosphatase activity database_cross_reference “Reactome:R-HSA-163689”
- label “PP2A complex dephosphorylates pChREBP (MLXIPL)”
protein serine/threonine phosphatase activity database_cross_reference “Reactome:R-HSA-163750”
- label “PP2A complex dephosphorylates pPFKFB1”

protein translocation chaperone activity `http://purl.obolibrary.org/obo/GO_0140388`

Added

protein translocation chaperone activity created by “pg”
protein translocation chaperone activity definition “Binding to the exposed unfolded portion of a polypeptide as it emerges from a membrane translocation channel/pore to drive its unidirectional transport across a membrane. Iterative cycles of ATP-dependent binding/rebinding by the chaperone prevents back sliding and drive vectorial transport.”
- database_cross_reference “PMID:11733493”
protein translocation chaperone activity label “protein translocation chaperone activity”
protein translocation chaperone activity creation date “2026-02-18T12:58:22Z”
protein translocation chaperone activity id “GO:0140388”
protein translocation chaperone activity has_related_synonym “import motor chaperone activity”
protein translocation chaperone activity has_related_synonym “translocation ratchet activity”
protein translocation chaperone activity term tracker item “https://github.com/geneontology/go-ontology/issues/31580”^^anyURI
protein translocation chaperone activity has_obo_namespace “molecular_function”
Class: protein translocation chaperone activity
protein translocation chaperone activity SubClassOf protein carrier activity
protein translocation chaperone activity SubClassOf ATP-dependent activity

protein transmembrane import into intracellular organelle `http://purl.obolibrary.org/obo/GO_0044743`

Added

protein transmembrane import into intracellular organelle SubClassOf intercellular transport

protein tyrosine kinase activity `http://purl.obolibrary.org/obo/GO_0004713`

Removed

protein tyrosine kinase activity database_cross_reference “Reactome:R-HSA-170156”
- label “Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes”

Added

protein tyrosine kinase activity database_cross_reference “Reactome:R-HSA-9934751”
- label “CDH1 is phosphorylated on tyrosine residues”
protein tyrosine kinase activity database_cross_reference “Reactome:R-HSA-170156”
- label “WEE1 phosphorylates CCNA:CDK1”
protein tyrosine kinase activity database_cross_reference “Reactome:R-HSA-9931290”
- label “IL6-activated JAK1 phosphorylates CD274”

protein-N(PI)-phosphohistidine-N,N’-diacetylchitobiose phosphotransferase system transporter activity `http://purl.obolibrary.org/obo/GO_0090562`

Added

protein-N(PI)-phosphohistidine-N,N’-diacetylchitobiose phosphotransferase system transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/31586”^^anyURI

protein-N(PI)-phosphohistidine-N-acetyl-mannosamine phosphotransferase system transporter activity `http://purl.obolibrary.org/obo/GO_0090591`

Added

protein-N(PI)-phosphohistidine-N-acetyl-mannosamine phosphotransferase system transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/31586”^^anyURI

protein-N(PI)-phosphohistidine-N-acetylgalactosamine phosphotransferase system transporter activity `http://purl.obolibrary.org/obo/GO_0022881`

Added

protein-N(PI)-phosphohistidine-N-acetylgalactosamine phosphotransferase system transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/31586”^^anyURI

protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity `http://purl.obolibrary.org/obo/GO_0022880`

Removed

protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity definition “Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylglucosamine(out) = protein histidine + N-acetylglucosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.”
- database_cross_reference “ISBN:0815340729”
- database_cross_reference “GOC:mtg_transport”

Added

protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity exactMatch 49240
protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity exactMatch 2.7.1.193
protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity database_cross_reference “RHEA:49240”
protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity database_cross_reference “EC:2.7.1.193”
protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity definition “Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane by the reaction: N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) = L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.”
- database_cross_reference “RHEA:49240”
- database_cross_reference “GOC:mtg_transport”
protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/31586”^^anyURI

protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity `http://purl.obolibrary.org/obo/GO_0022882`

Removed

protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity definition “Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.”
- database_cross_reference “ISBN:0815340729”
- database_cross_reference “GOC:mtg_transport”
protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity SubClassOf beta-glucoside transmembrane transporter activity

Added

protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/31586”^^anyURI
protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity definition “Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.”
- database_cross_reference “GOC:mtg_transport”
- database_cross_reference “PMID:19251853”

protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity `http://purl.obolibrary.org/obo/GO_0008982`

Removed

protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity definition “Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.”
- database_cross_reference “ISBN:0815340729”
- database_cross_reference “GOC:mtg_transport”
protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity label “protein-N(PI)-phosphohistidine-sugar phosphotransferase activity”

Added

protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity definition “Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.”
- database_cross_reference “PMID:31214989”
- database_cross_reference “PMID:16339738”
- database_cross_reference “GOC:mtg_transport”
protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity has_related_synonym “protein-N(PI)-phosphohistidine-sugar phosphotransferase activity”
protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity label “protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity”
protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31586”^^anyURI

protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity `http://purl.obolibrary.org/obo/GO_0022874`

Removed

protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity definition “Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + cellobiose(out) = protein histidine + cellobiose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.”
- database_cross_reference “ISBN:0815340729”
- database_cross_reference “GOC:mtg_transport”

Added

protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity exactMatch 49292
protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/31586”^^anyURI
protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity exactMatch 2.7.1.205
protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity database_cross_reference “EC:2.7.1.205”
protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity definition “Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane according to the reaction: D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein] = 6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein]. This differs from primary and secondary active transport in that the solute is modified during transport.”
- database_cross_reference “GOC:mtg_transport”
- database_cross_reference “RHEA:49292”
protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity database_cross_reference “RHEA:49292”

protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity `http://purl.obolibrary.org/obo/GO_0022877`

Added

protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/31586”^^anyURI

protein-N(PI)-phosphohistidine-galactitol phosphotransferase system transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0022875`

Added

protein-N(PI)-phosphohistidine-galactitol phosphotransferase system transmembrane transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/31586”^^anyURI

protein-N(PI)-phosphohistidine-galactosamine phosphotransferase system transporter activity `http://purl.obolibrary.org/obo/GO_0022876`

Added

protein-N(PI)-phosphohistidine-galactosamine phosphotransferase system transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/31586”^^anyURI

protein-N(PI)-phosphohistidine-glucose phosphotransferase system transporter activity `http://purl.obolibrary.org/obo/GO_0022855`

Added

protein-N(PI)-phosphohistidine-glucose phosphotransferase system transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/31586”^^anyURI

protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity `http://purl.obolibrary.org/obo/GO_0022869`

Added

protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/31586”^^anyURI

protein-N(PI)-phosphohistidine-maltose phosphotransferase system transporter activity `http://purl.obolibrary.org/obo/GO_0022873`

Added

protein-N(PI)-phosphohistidine-maltose phosphotransferase system transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/31586”^^anyURI

protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0022872`

Added

protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/31586”^^anyURI

protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity `http://purl.obolibrary.org/obo/GO_0022870`

Removed

protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity definition “Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannose(out) = protein histidine + mannose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.”
- database_cross_reference “ISBN:0815340729”
- database_cross_reference “GOC:mtg_transport”

Added

protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity exactMatch 2.7.1.191
protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity database_cross_reference “EC:2.7.1.191”
protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity exactMatch 49232
protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity database_cross_reference “RHEA:49232”
protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity definition “Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane according to the reaction: D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] = D-mannose 6-phosphate(in) + L-histidyl-[protein]. This differs from primary and secondary active transport in that the solute is modified during transport.”
- database_cross_reference “RHEA:49232”
- database_cross_reference “GOC:mtg_transport”
protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/31586”^^anyURI

protein-N(PI)-phosphohistidine-sorbitol phosphotransferase system transporter activity `http://purl.obolibrary.org/obo/GO_0022856`

Added

protein-N(PI)-phosphohistidine-sorbitol phosphotransferase system transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/31586”^^anyURI

protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity `http://purl.obolibrary.org/obo/GO_0022871`

Removed

protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity narrowMatch 49296

Added

protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity exactMatch 49296
protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/31586”^^anyURI

protein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity `http://purl.obolibrary.org/obo/GO_0022878`

Added

protein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity exactMatch 2.7.1.211
protein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/31586”^^anyURI
protein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity database_cross_reference “EC:2.7.1.211”

protein-N(PI)-phosphohistidine-trehalose phosphotransferase system transporter activity `http://purl.obolibrary.org/obo/GO_0022879`

Added

protein-N(PI)-phosphohistidine-trehalose phosphotransferase system transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/31586”^^anyURI

protein-N-terminal amino-acid acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0004596`

Added

protein-N-terminal glutamine amidohydrolase activity `http://purl.obolibrary.org/obo/GO_0070773`

Removed

protein-N-terminal glutamine amidohydrolase activity definition “Catalysis of the reaction: N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH3. This reaction is the deamidation of an N-terminal glutamine residue of a protein.”
- database_cross_reference “PMID:19560421”
- database_cross_reference “RHEA:50680”

Added

protein-N-terminal glutamine amidohydrolase activity definition “Catalysis of the reaction: N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH4+. This reaction is the deamidation of an N-terminal glutamine residue of a protein.”
- database_cross_reference “PMID:19560421”
- database_cross_reference “RHEA:50680”

protein-N-terminal-alanine acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0008999`

Added

protein-cysteine S-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0019707`

Added

protein-cysteine S-acyltransferase activity database_cross_reference “Reactome:R-HSA-174959”
- label “The acetyl group from acetyl-CoA is transferred to NAT1”
protein-cysteine S-acyltransferase activity database_cross_reference “Reactome:R-HSA-158832”
- label “The acetyl group from acetyl-CoA is transferred to NAT2”

protein-disulfide reductase activity `http://purl.obolibrary.org/obo/GO_0015035`

Removed

protein-disulfide reductase activity database_cross_reference “MetaCyc:DISULFOXRED-RXN”
protein-disulfide reductase activity definition “Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds.”
- database_cross_reference “PMID:7559385”

Added

protein-disulfide reductase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31518”^^anyURI
protein-disulfide reductase activity definition “Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds.”
- database_cross_reference “PMID:18331844”

protein-exporting ATPase activity `http://purl.obolibrary.org/obo/GO_0008564`

Added

protein-exporting ATPase activity database_cross_reference “Reactome:R-HSA-9926041”
- label “HlyB:HlyD:TolC transports HlyA from cytosol to periplasm”
protein-exporting ATPase activity database_cross_reference “Reactome:R-HSA-9760310”
- label “SecA:SecYEG transports proteins from cytosol to periplasmic space”

protein-glutamic acid ligase activity, elongating `http://purl.obolibrary.org/obo/GO_0106438`

Added

protein-glutamic acid ligase activity, initiating `http://purl.obolibrary.org/obo/GO_0106437`

Added

protein-glutaminase activity `http://purl.obolibrary.org/obo/GO_0050170`

Removed

protein-glutaminase activity definition “Catalysis of the reaction: alpha-N-peptidyl-L-glutamine + H2O = alpha-N-peptidyl-L-glutamate + NH3.”
- database_cross_reference “MetaCyc:PEPTIDYL-GLUTAMINASE-RXN”
- database_cross_reference “EC:3.5.1.43”
protein-glutaminase activity label “peptidyl-glutaminase activity”

Added

protein-glutaminase activity narrowMatch 47952
protein-glutaminase activity label “protein-glutaminase activity”
protein-glutaminase activity definition “Catalysis of the reaction: [protein]-C-terminal-L-glutamine + H2O = [protein]-C-terminal-L-glutamate + NH4+.”
- database_cross_reference “RHEA:10032”
protein-glutaminase activity database_cross_reference “RHEA:47952”
protein-glutaminase activity has_exact_synonym “peptidyl-glutaminase activity”

protein-glutamine N-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0036009`

Added

protein-glutamine gamma-glutamyltransferase activity `http://purl.obolibrary.org/obo/GO_0003810`

Removed

protein-glutamine gamma-glutamyltransferase activity database_cross_reference “RESID:AA0124”

protein-glutamine glutaminase activity `http://purl.obolibrary.org/obo/GO_0050568`

Removed

protein-glutamine glutaminase activity definition “Catalysis of the reaction: protein L-glutamine + H2O = protein L-glutamate + NH3.”
- database_cross_reference “EC:3.5.1.44”
- database_cross_reference “MetaCyc:CHEBDEAMID-RXN”

Added

protein-glutamine glutaminase activity definition “Catalysis of the reaction: L-glutaminyl-[protein] + H2O = L-glutamyl-[protein] + NH4+.”
- database_cross_reference “RHEA:16441”

protein-glutaryllysine deglutarylase activity `http://purl.obolibrary.org/obo/GO_0061697`

Added

protein-glutaryllysine deglutarylase activity database_cross_reference “Reactome:R-HSA-9955504”
- label “SIRT5 deglutarylates CPS1”

protein-lysine 6-oxidase activity `http://purl.obolibrary.org/obo/GO_0004720`

Removed

protein-lysine 6-oxidase activity definition “Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide.”
- database_cross_reference “EC:1.4.3.13”

Added

protein-lysine 6-oxidase activity definition “Catalysis of the reaction: L-lysyl-[protein] + O2 + H2O = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4+.”
- database_cross_reference “RHEA:24544”

protein-lysine lysyltransferase activity `http://purl.obolibrary.org/obo/GO_0052868`

Removed

protein-lysine lysyltransferase activity definition “Catalysis of the reaction: protein-lysine + protein-lysine = protein N6-(lysyl)-L-lysine + protein. This reaction is the addition of lysine group from one protein to a lysine residue in a second protein, producing N6-(lysyl)-L-lysine.”
- database_cross_reference “PMID:20729861”

Added

protein-lysine lysyltransferase activity database_cross_reference “RHEA:83435”
protein-lysine lysyltransferase activity definition “Catalysis of the reaction: D-beta-lysine + L-lysyl-[protein] + ATP = N6-((3R)-3,6-diaminohexanoyl)-L-lysyl-[protein] + AMP + diphosphate + H+n. This reaction is the addition of lysine group from one protein to a lysine residue in a second protein, producing N6-(lysyl)-L-lysine.”
- database_cross_reference “PMID:20729861”
- database_cross_reference “RHEA:83435”
protein-lysine lysyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31478”^^anyURI

protein-lysine-acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0061733`

Removed

protein-lysine-acetyltransferase activity has_broad_synonym “protein acetyltransferase activity”
protein-lysine-acetyltransferase activity has_broad_synonym “protein acetylase activity”

Added

protein-lysine-acetyltransferase activity database_cross_reference “RHEA:74151”
protein-lysine-acetyltransferase activity narrowMatch 74151
protein-lysine-acetyltransferase activity has_exact_synonym “protein acetyltransferase activity”
protein-lysine-acetyltransferase activity database_cross_reference “Reactome:R-HSA-9920716”
- label “CLOCK acetylates BMAL1 on lysine-538”
protein-lysine-acetyltransferase activity has_exact_synonym “protein acetylase activity”

protein-macromolecule adaptor activity `http://purl.obolibrary.org/obo/GO_0030674`

Added

protein-macromolecule adaptor activity database_cross_reference “Reactome:R-HSA-3781001”
- label “EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG1 complex”
protein-macromolecule adaptor activity database_cross_reference “Reactome:R-HSA-8871376”
- label “p-Y389,400-RUFY1 binds PI3P”
protein-macromolecule adaptor activity database_cross_reference “Reactome:R-HSA-3780997”
- label “PPP1R3C binds to glycogen:GYG2:GYS2”
protein-macromolecule adaptor activity database_cross_reference “Reactome:R-HSA-3781021”
- label “EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG2 complex”
protein-macromolecule adaptor activity database_cross_reference “Reactome:R-HSA-8871366”
- label “p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP”
protein-macromolecule adaptor activity database_cross_reference “Reactome:R-HSA-3781023”
- label “PPP1R3C binds to glycogen:GYG1:GYS1”

protein-membrane adaptor activity `http://purl.obolibrary.org/obo/GO_0043495`

Removed

protein-membrane adaptor activity definition “The binding activity of a molecule that brings together a protein or a protein complex with a membrane, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle.”
- database_cross_reference “GOC:go_curators”

Added

protein-membrane adaptor activity definition “The binding activity of a molecule that brings together a protein or a protein complex with a membrane, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle.”
- database_cross_reference “GOC:curators”
protein-membrane adaptor activity database_cross_reference “Reactome:R-HSA-6809764”
- label “SBF1 binds MTMR2”
protein-membrane adaptor activity database_cross_reference “Reactome:R-HSA-5333678”
- label “CPNEs bind PL”

protein-succinyllysine desuccinylase activity `http://purl.obolibrary.org/obo/GO_0036055`

Added

protein-succinyllysine desuccinylase activity database_cross_reference “Reactome:R-HSA-9955518”
- label “SIRT5 desuccinylates CPS1”

proteoglycan catabolic process `http://purl.obolibrary.org/obo/GO_0030167`

Added

proteoglycan catabolic process database_cross_reference “Reactome:R-HSA-2024101”
- label “CS/DS degradation”

proteoglycan metabolic process `http://purl.obolibrary.org/obo/GO_0006029`

Added

proteoglycan metabolic process database_cross_reference “Reactome:R-HSA-1793185”
- label “Chondroitin sulfate/dermatan sulfate metabolism”

protoporphyrin ferrochelatase activity `http://purl.obolibrary.org/obo/GO_0004325`

Removed

protoporphyrin ferrochelatase activity label “ferrochelatase activity”

Added

protoporphyrin ferrochelatase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31620”^^anyURI
protoporphyrin ferrochelatase activity label “protoporphyrin ferrochelatase activity”
protoporphyrin ferrochelatase activity has_broad_synonym “ferrochelatase activity”

protoporphyrinogen IX biosynthetic process `http://purl.obolibrary.org/obo/GO_0006782`

Removed

protoporphyrinogen IX biosynthetic process definition “The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX.”
- database_cross_reference “GOC:go_curators”

Added

protoporphyrinogen IX biosynthetic process definition “The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX.”
- database_cross_reference “GOC:curators”

protoporphyrinogen IX biosynthetic process from glycine `http://purl.obolibrary.org/obo/GO_0019352`

Removed

protoporphyrinogen IX biosynthetic process from glycine definition “The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glycine.”
- database_cross_reference “GOC:go_curators”

Added

protoporphyrinogen IX biosynthetic process from glycine definition “The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glycine.”
- database_cross_reference “GOC:curators”

proximal/distal axis specification `http://purl.obolibrary.org/obo/GO_0009946`

Removed

proximal/distal axis specification definition “The establishment, maintenance and elaboration of the proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end).”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

proximal/distal axis specification definition “The establishment, maintenance and elaboration of the proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end).”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

proximal/distal pattern formation `http://purl.obolibrary.org/obo/GO_0009954`

Removed

proximal/distal pattern formation definition “The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end).”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:isa_complete”
- database_cross_reference “GOC:go_curators”

Added

proximal/distal pattern formation definition “The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end).”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:isa_complete”

pseudouridine synthase activity `http://purl.obolibrary.org/obo/GO_0009982`

Removed

pseudouridine synthase activity database_cross_reference “Reactome:R-HSA-6786583”
- label “PUS7 transforms uridine to pseudouridine in tRNAs”
pseudouridine synthase activity database_cross_reference “Reactome:R-HSA-8870289”
- label “PUS3 transforms uridine-39 to pseudouridine-39 in tRNA”
pseudouridine synthase activity database_cross_reference “Reactome:R-HSA-6782381”
- label “PUS1 isoform 2 transforms uridine residues to pseudouridine in the anticodon stems of tRNAs”
pseudouridine synthase activity database_cross_reference “Reactome:R-HSA-6787566”
- label “PUS1 isoform 1 transforms uridine-27, uridine-28 yielding pseudouridine in tRNA(Lys,Ser)”

Added

pseudouridine synthase activity narrowMatch 56644
pseudouridine synthase activity database_cross_reference “Reactome:R-HSA-9936243”
- label “RPUSD4 in the mitochondrial pseudouridylation module transforms uridine-1397 to pseudouridine-1397 in mitochondrial 16S rRNA”
pseudouridine synthase activity database_cross_reference “Reactome:R-HSA-6786583”
- label “PUS7 isomerizes uridine to pseudouridine in tRNAs”
pseudouridine synthase activity database_cross_reference “Reactome:R-HSA-9937369”
- label “RPUSD3,TRUB2 pseudouridylates MT-CO1,MT-CO3 mRNA”
pseudouridine synthase activity database_cross_reference “RHEA:56644”
pseudouridine synthase activity database_cross_reference “Reactome:R-HSA-6787566”
- label “PUS1 isoform 1 isomerizes uridine-27, uridine-28 to pseudouridine residues in tRNA(Lys,Ser)”
pseudouridine synthase activity database_cross_reference “Reactome:R-HSA-6782381”
- label “PUS1 isoform 2 isomerizes uridine residues to pseudouridine residues in the anticodon stems of tRNAs”
pseudouridine synthase activity database_cross_reference “Reactome:R-HSA-8870289”
- label “PUS3 isomerizes uridine-39 to pseudouridine-39 in tRNA”

pteridine metabolic process `http://purl.obolibrary.org/obo/GO_0019889`

Removed

pteridine metabolic process definition “The chemical reactions and pathways involving pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pteridine metabolic process definition “The chemical reactions and pathways involving pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pterin deaminase activity `http://purl.obolibrary.org/obo/GO_0050228`

Added

pterin deaminase activity narrowMatch 11904
pterin deaminase activity database_cross_reference “RHEA:11904”

pterocarpan synthase activity `http://purl.obolibrary.org/obo/GO_0140859`

Added

pterocarpan synthase activity narrowMatch 35811
pterocarpan synthase activity database_cross_reference “RHEA:35811”

purine deoxyribonucleoside binding `http://purl.obolibrary.org/obo/GO_0032547`

Removed

purine deoxyribonucleoside binding SubClassOf deoxyribonucleoside binding

purine deoxyribonucleoside biosynthetic process `http://purl.obolibrary.org/obo/GO_0046123`

Removed

purine deoxyribonucleoside biosynthetic process SubClassOf 2’-deoxyribonucleoside biosynthetic process

purine deoxyribonucleoside catabolic process `http://purl.obolibrary.org/obo/GO_0046124`

Removed

purine deoxyribonucleoside catabolic process SubClassOf 2’-deoxyribonucleoside catabolic process

purine deoxyribonucleoside diphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009183`

Removed

purine deoxyribonucleoside diphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine deoxyribonucleoside diphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine deoxyribonucleoside diphosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009184`

Removed

purine deoxyribonucleoside diphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine deoxyribonucleoside diphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine deoxyribonucleoside diphosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009182`

Removed

purine deoxyribonucleoside diphosphate metabolic process definition “The chemical reactions and pathways involving purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine deoxyribonucleoside diphosphate metabolic process definition “The chemical reactions and pathways involving purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine deoxyribonucleoside metabolic process `http://purl.obolibrary.org/obo/GO_0046122`

Removed

purine deoxyribonucleoside metabolic process SubClassOf 2’-deoxyribonucleoside metabolic process

purine deoxyribonucleoside monophosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009171`

Removed

purine deoxyribonucleoside monophosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine deoxyribonucleoside monophosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine deoxyribonucleoside monophosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009172`

Removed

purine deoxyribonucleoside monophosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine deoxyribonucleoside monophosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine deoxyribonucleoside monophosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009170`

Removed

purine deoxyribonucleoside monophosphate metabolic process definition “The chemical reactions and pathways involving purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine deoxyribonucleoside monophosphate metabolic process definition “The chemical reactions and pathways involving purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine deoxyribonucleoside triphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009216`

Removed

purine deoxyribonucleoside triphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine deoxyribonucleoside triphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine deoxyribonucleoside triphosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009217`

Removed

purine deoxyribonucleoside triphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine deoxyribonucleoside triphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine deoxyribonucleoside triphosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009215`

Removed

purine deoxyribonucleoside triphosphate metabolic process definition “The chemical reactions and pathways involving purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine deoxyribonucleoside triphosphate metabolic process definition “The chemical reactions and pathways involving purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine deoxyribonucleotide binding `http://purl.obolibrary.org/obo/GO_0032554`

Removed

purine deoxyribonucleotide binding SubClassOf deoxyribonucleotide binding

Added

purine deoxyribonucleotide binding SubClassOf carbohydrate derivative binding

purine deoxyribonucleotide biosynthetic process `http://purl.obolibrary.org/obo/GO_0009153`

Removed

purine deoxyribonucleotide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine deoxyribonucleotide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine deoxyribonucleotide catabolic process `http://purl.obolibrary.org/obo/GO_0009155`

Removed

purine deoxyribonucleotide catabolic process definition “The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”
purine deoxyribonucleotide catabolic process SubClassOf deoxyribonucleotide catabolic process

Added

purine deoxyribonucleotide catabolic process definition “The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine deoxyribonucleotide metabolic process `http://purl.obolibrary.org/obo/GO_0009151`

Removed

purine deoxyribonucleotide metabolic process definition “The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine deoxyribonucleotide metabolic process definition “The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine fermentation `http://purl.obolibrary.org/obo/GO_0019653`

Removed

purine fermentation has_exact_synonym “anaerobic purine base catabolic process”
- database_cross_reference “GOC:go_curators”

Added

purine fermentation has_exact_synonym “anaerobic purine base catabolic process”
- database_cross_reference “GOC:curators”

purine nucleobase binding `http://purl.obolibrary.org/obo/GO_0002060`

Removed

purine nucleobase binding has_exact_synonym “purine base binding”
- database_cross_reference “GOC:go_curators”

Added

purine nucleobase binding has_exact_synonym “purine base binding”
- database_cross_reference “GOC:curators”

purine nucleobase biosynthetic process `http://purl.obolibrary.org/obo/GO_0009113`

Removed

purine nucleobase biosynthetic process database_cross_reference “MetaCyc:PWY-841”
purine nucleobase biosynthetic process has_exact_synonym “purine base biosynthetic process”
- database_cross_reference “GOC:go_curators”

Added

purine nucleobase biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
purine nucleobase biosynthetic process has_exact_synonym “purine base biosynthetic process”
- database_cross_reference “GOC:curators”

purine nucleobase catabolic process `http://purl.obolibrary.org/obo/GO_0006145`

Removed

purine nucleobase catabolic process has_exact_synonym “purine base catabolic process”
- database_cross_reference “GOC:go_curators”
purine nucleobase catabolic process definition “The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.”
- database_cross_reference “GOC:go_curators”

Added

purine nucleobase catabolic process has_exact_synonym “purine base catabolic process”
- database_cross_reference “GOC:curators”
purine nucleobase catabolic process definition “The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.”
- database_cross_reference “GOC:curators”

purine nucleobase metabolic process `http://purl.obolibrary.org/obo/GO_0006144`

Removed

purine nucleobase metabolic process definition “The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.”
- database_cross_reference “GOC:go_curators”
purine nucleobase metabolic process has_exact_synonym “purine base metabolic process”
- database_cross_reference “GOC:go_curators”

Added

purine nucleobase metabolic process has_exact_synonym “purine base metabolic process”
- database_cross_reference “GOC:curators”
purine nucleobase metabolic process definition “The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.”
- database_cross_reference “GOC:curators”

purine nucleobase salvage `http://purl.obolibrary.org/obo/GO_0043096`

Removed

purine nucleobase salvage has_exact_synonym “purine base salvage”
- database_cross_reference “GOC:go_curators”

Added

purine nucleobase salvage has_exact_synonym “purine base salvage”
- database_cross_reference “GOC:curators”

purine nucleobase transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0005345`

Removed

purine nucleobase transmembrane transporter activity has_exact_synonym “purine base transmembrane transporter activity”
- database_cross_reference “GOC:go_curators”

Added

purine nucleobase transmembrane transporter activity has_exact_synonym “purine base transmembrane transporter activity”
- database_cross_reference “GOC:curators”

purine nucleobase transport `http://purl.obolibrary.org/obo/GO_0006863`

Removed

purine nucleobase transport has_exact_synonym “purine base transport”
- database_cross_reference “GOC:go_curators”

Added

purine nucleobase transport has_exact_synonym “purine base transport”
- database_cross_reference “GOC:curators”

purine nucleosidase activity `http://purl.obolibrary.org/obo/GO_0008477`

Added

purine nucleosidase activity database_cross_reference “RHEA:30771”
purine nucleosidase activity narrowMatch 30771

purine nucleoside biosynthetic process `http://purl.obolibrary.org/obo/GO_0042451`

Removed

purine nucleoside biosynthetic process definition “The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).”
- database_cross_reference “GOC:go_curators”

Added

purine nucleoside biosynthetic process definition “The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).”
- database_cross_reference “GOC:curators”

purine nucleoside catabolic process `http://purl.obolibrary.org/obo/GO_0006152`

Removed

purine nucleoside catabolic process definition “The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).”
- database_cross_reference “GOC:go_curators”

Added

purine nucleoside catabolic process definition “The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).”
- database_cross_reference “GOC:curators”

purine nucleoside diphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009136`

Removed

purine nucleoside diphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine nucleoside diphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine nucleoside diphosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009137`

Removed

purine nucleoside diphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine nucleoside diphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine nucleoside diphosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009135`

Removed

purine nucleoside diphosphate metabolic process definition “The chemical reactions and pathways involving purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine nucleoside diphosphate metabolic process definition “The chemical reactions and pathways involving purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine nucleoside monophosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009127`

Removed

purine nucleoside monophosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine nucleoside monophosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine nucleoside monophosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009128`

Removed

purine nucleoside monophosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine nucleoside monophosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine nucleoside monophosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009126`

Removed

purine nucleoside monophosphate metabolic process definition “The chemical reactions and pathways involving purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine nucleoside monophosphate metabolic process definition “The chemical reactions and pathways involving purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine nucleoside triphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009145`

Removed

purine nucleoside triphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine nucleoside triphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine nucleoside triphosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009146`

Removed

purine nucleoside triphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine nucleoside triphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine nucleoside triphosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009144`

Removed

purine nucleoside triphosphate metabolic process definition “The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine nucleoside triphosphate metabolic process definition “The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine nucleotide biosynthetic process `http://purl.obolibrary.org/obo/GO_0006164`

Removed

purine nucleotide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”
purine nucleotide biosynthetic process database_cross_reference “MetaCyc:DENOVOPURINE2-PWY”

Added

purine nucleotide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”
purine nucleotide biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI

purine nucleotide catabolic process `http://purl.obolibrary.org/obo/GO_0006195`

Removed

purine nucleotide catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine nucleotide catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine nucleotide import into lysosome `http://purl.obolibrary.org/obo/GO_0141013`

Added

purine nucleotide import into lysosome SubClassOf intercellular transport

purine nucleotide metabolic process `http://purl.obolibrary.org/obo/GO_0006163`

Removed

purine nucleotide metabolic process definition “The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine nucleotide metabolic process definition “The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine ribonucleoside diphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009180`

Removed

purine ribonucleoside diphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine ribonucleoside diphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine ribonucleoside diphosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009181`

Removed

purine ribonucleoside diphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine ribonucleoside diphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine ribonucleoside diphosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009179`

Removed

purine ribonucleoside diphosphate metabolic process definition “The chemical reactions and pathways involving purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine ribonucleoside diphosphate metabolic process definition “The chemical reactions and pathways involving purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine ribonucleoside monophosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009168`

Removed

purine ribonucleoside monophosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine ribonucleoside monophosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine ribonucleoside monophosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009169`

Removed

purine ribonucleoside monophosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine ribonucleoside monophosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine ribonucleoside monophosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009167`

Removed

purine ribonucleoside monophosphate metabolic process definition “The chemical reactions and pathways involving purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine ribonucleoside monophosphate metabolic process definition “The chemical reactions and pathways involving purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine ribonucleoside salvage `http://purl.obolibrary.org/obo/GO_0006166`

Removed

purine ribonucleoside salvage database_cross_reference “MetaCyc:P121-PWY”

purine ribonucleoside triphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009206`

Removed

purine ribonucleoside triphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine ribonucleoside triphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine ribonucleoside triphosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009207`

Removed

purine ribonucleoside triphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine ribonucleoside triphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine ribonucleoside triphosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009205`

Removed

purine ribonucleoside triphosphate metabolic process definition “The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine ribonucleoside triphosphate metabolic process definition “The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine ribonucleotide biosynthetic process `http://purl.obolibrary.org/obo/GO_0009152`

Removed

purine ribonucleotide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine ribonucleotide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine ribonucleotide catabolic process `http://purl.obolibrary.org/obo/GO_0009154`

Removed

purine ribonucleotide catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine ribonucleotide catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine ribonucleotide metabolic process `http://purl.obolibrary.org/obo/GO_0009150`

Removed

purine ribonucleotide metabolic process definition “The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

purine ribonucleotide metabolic process definition “The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

purine-nucleoside phosphorylase activity `http://purl.obolibrary.org/obo/GO_0004731`

Added

purine-nucleoside phosphorylase activity database_cross_reference “RHEA:27642”
purine-nucleoside phosphorylase activity narrowMatch 27642
purine-nucleoside phosphorylase activity narrowMatch 27646
purine-nucleoside phosphorylase activity database_cross_reference “RHEA:27638”
purine-nucleoside phosphorylase activity database_cross_reference “RHEA:27646”
purine-nucleoside phosphorylase activity narrowMatch 27638

putrescine biosynthetic process `http://purl.obolibrary.org/obo/GO_0009446`

Removed

putrescine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane; putrescine can be synthesized from arginine or ornithine and is the metabolic precursor of spermidine and spermine.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

putrescine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane; putrescine can be synthesized from arginine or ornithine and is the metabolic precursor of spermidine and spermine.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

putrescine catabolic process `http://purl.obolibrary.org/obo/GO_0009447`

Added

putrescine catabolic process database_cross_reference “MetaCyc:PWY-0”
putrescine catabolic process database_cross_reference “MetaCyc:PWY0-1221”
putrescine catabolic process narrowMatch PWY-0
putrescine catabolic process database_cross_reference “MetaCyc:PUTDEG-PWY”
putrescine catabolic process narrowMatch PWY-2
putrescine catabolic process database_cross_reference “MetaCyc:PWY-2”
putrescine catabolic process narrowMatch PUTDEG-PWY
putrescine catabolic process narrowMatch PWY-3
putrescine catabolic process narrowMatch PWY0-1221
putrescine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31766”^^anyURI
putrescine catabolic process database_cross_reference “MetaCyc:PWY-3”

putrescine:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0033094`

Removed

putrescine:2-oxoglutarate transaminase activity label “putrescine–2-oxoglutarate transaminase activity”
putrescine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H2O. The enzymatic part of the reaction produces 4-aminobutanal that spontaneously cyclizes to form 1-pyrroline.”
- database_cross_reference “RHEA:12268”
- database_cross_reference “EC:2.6.1.82”
- database_cross_reference “GOC:mlg”

Added

putrescine:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
putrescine:2-oxoglutarate transaminase activity has_exact_synonym “putrescine–2-oxoglutarate transaminase activity”
putrescine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H2O. The enzymatic part of the reaction produces 4-aminobutanal that spontaneously cyclizes to form 1-pyrroline.”
- database_cross_reference “RHEA:12268”
- database_cross_reference “EC:2.6.1.82”
putrescine:2-oxoglutarate transaminase activity label “putrescine:2-oxoglutarate transaminase activity”

pyridinol guanylyltransferase activity `http://purl.obolibrary.org/obo/GO_0160298`

Removed

pyridinol guanylyltransferase activity definition “Catalysis of the reaction: 6-carboxymethyl-3,5-dimethyl-4-hydroxypyridin-2-ol + GTP + H+ = guanylylpyridinol + diphosphate.”
- database_cross_reference “PMID:24249552”

Added

pyridinol guanylyltransferase activity definition “Catalysis of the reaction: 6-carboxymethyl-3,5-dimethyl-4-hydroxypyridin-2-ol + GTP + H+ = guanylylpyridinol + diphosphate.”
- database_cross_reference “RHEA:85479”
- database_cross_reference “PMID:24249552”
pyridinol guanylyltransferase activity database_cross_reference “RHEA:85479”
pyridinol guanylyltransferase activity exactMatch 2.7.7.109
pyridinol guanylyltransferase activity exactMatch 85479
pyridinol guanylyltransferase activity database_cross_reference “EC:2.7.7.109”

pyridoxal 5’-phosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0042823`

Removed

pyridoxal 5’-phosphate biosynthetic process label “pyridoxal phosphate biosynthetic process”

Added

pyridoxal 5’-phosphate biosynthetic process label “pyridoxal 5’-phosphate biosynthetic process”

pyridoxal 5’-phosphate catabolic process `http://purl.obolibrary.org/obo/GO_0032361`

Removed

pyridoxal 5’-phosphate catabolic process label “pyridoxal phosphate catabolic process”

Added

pyridoxal 5’-phosphate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
pyridoxal 5’-phosphate catabolic process label “pyridoxal 5’-phosphate catabolic process”

pyridoxal 5’-phosphate metabolic process `http://purl.obolibrary.org/obo/GO_0042822`

Removed

pyridoxal 5’-phosphate metabolic process label “pyridoxal phosphate metabolic process”

Added

pyridoxal 5’-phosphate metabolic process label “pyridoxal 5’-phosphate metabolic process”

pyridoxal 5’-phosphate salvage `http://purl.obolibrary.org/obo/GO_0009443`

Added

pyridoxal 5’-phosphate salvage narrowMatch PWY-7204
pyridoxal 5’-phosphate salvage term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
pyridoxal 5’-phosphate salvage database_cross_reference “MetaCyc:PWY-7204”
pyridoxal 5’-phosphate salvage narrowMatch PLPSAL-PWY

pyridoxal 5’-phosphate synthase (glutamine hydrolysing) activity `http://purl.obolibrary.org/obo/GO_0036381`

Removed

pyridoxal 5’-phosphate synthase (glutamine hydrolysing) activity definition “Catalysis of the reaction: D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5’-phosphate + L-glutamate + 3 H2O + phosphate. The reaction occurs in two steps: L-glutamine + H2O = L-glutamate + NH3, and subsequently D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5’-phosphate + 4 H2O + phosphate.”
- database_cross_reference “EC:4.3.3.6”
- database_cross_reference “GOC:rs”

Added

pyridoxal 5’-phosphate synthase (glutamine hydrolysing) activity definition “Catalysis of the reaction: D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5’-phosphate + L-glutamate + 3 H2O + phosphate. The reaction occurs in two steps: L-glutamine + H2O = L-glutamate + NH4+, and subsequently D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4+ = pyridoxal 5’-phosphate + 4 H2O + phosphate.”
- database_cross_reference “EC:4.3.3.6”
- database_cross_reference “GOC:rs”

pyridoxamine phosphate oxidase activity `http://purl.obolibrary.org/obo/GO_0004733`

Removed

pyridoxamine phosphate oxidase activity definition “Catalysis of the reaction: pyridoxamine 5’-phosphate + H2O + O2 = pyridoxal 5’-phosphate + NH4+ + hydrogen peroxide. This activity can also oxidize pyridoxine 5’-phosphate to pyridoxal 5’-phosphate + hydrogen peroxide.”
- database_cross_reference “PMID:11786019”
pyridoxamine phosphate oxidase activity exactMatch 15817

Added

pyridoxamine phosphate oxidase activity narrowMatch 15149
pyridoxamine phosphate oxidase activity narrowMatch 15817
pyridoxamine phosphate oxidase activity definition “Catalysis of the reaction: pyridoxamine 5’-phosphate + H2O + O2 = pyridoxal 5’-phosphate + NH4+ + H2O2. This activity can also oxidize pyridoxine 5’-phosphate to pyridoxal 5’-phosphate + H2O2.”
- database_cross_reference “EC:1.4.3.5”
- database_cross_reference “PMID:11786019”
pyridoxamine phosphate oxidase activity database_cross_reference “RHEA:15149”

pyridoxamine-phosphate:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0019163`

Removed

pyridoxamine-phosphate:2-oxoglutarate transaminase activity label “pyridoxamine-phosphate transaminase activity”
pyridoxamine-phosphate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: pyridoxamine 5’-phosphate + 2-oxoglutarate = pyridoxal 5’-phosphate + D-glutamate.”
- database_cross_reference “EC:2.6.1.54”

Added

pyridoxamine-phosphate:2-oxoglutarate transaminase activity has_broad_synonym “pyridoxamine-phosphate transaminase activity”
pyridoxamine-phosphate:2-oxoglutarate transaminase activity label “pyridoxamine-phosphate:2-oxoglutarate transaminase activity”
pyridoxamine-phosphate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: pyridoxamine 5’-phosphate + 2-oxoglutarate = pyridoxal 5’-phosphate + D-glutamate.”
- database_cross_reference “RHEA:15877”
pyridoxamine-phosphate:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI

pyridoxamine:oxaloacetate transaminase activity `http://purl.obolibrary.org/obo/GO_0019162`

Removed

pyridoxamine:oxaloacetate transaminase activity definition “Catalysis of the reaction: oxaloacetate + pyridoxamine = L-aspartate + pyridoxal.”
- database_cross_reference “RHEA:10844”
- database_cross_reference “EC:2.6.1.31”
pyridoxamine:oxaloacetate transaminase activity label “pyridoxamine-oxaloacetate transaminase activity”

Added

pyridoxamine:oxaloacetate transaminase activity has_exact_synonym “pyridoxamine-oxaloacetate transaminase activity”
pyridoxamine:oxaloacetate transaminase activity label “pyridoxamine:oxaloacetate transaminase activity”
pyridoxamine:oxaloacetate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
pyridoxamine:oxaloacetate transaminase activity definition “Catalysis of the reaction: oxaloacetate + pyridoxamine = L-aspartate + pyridoxal.”
- database_cross_reference “RHEA:10844”

pyridoxamine:pyruvate transaminase activity `http://purl.obolibrary.org/obo/GO_0047300`

Removed

pyridoxamine:pyruvate transaminase activity label “pyridoxamine-pyruvate transaminase activity”
pyridoxamine:pyruvate transaminase activity definition “Catalysis of the reaction: pyridoxamine + pyruvate = L-alanine + pyridoxal.”
- database_cross_reference “RHEA:12841”
- database_cross_reference “EC:2.6.1.30”

Added

pyridoxamine:pyruvate transaminase activity label “pyridoxamine:pyruvate transaminase activity”
pyridoxamine:pyruvate transaminase activity definition “Catalysis of the reaction: pyridoxamine + pyruvate = L-alanine + pyridoxal.”
- database_cross_reference “RHEA:12841”
pyridoxamine:pyruvate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
pyridoxamine:pyruvate transaminase activity has_exact_synonym “pyridoxamine-pyruvate transaminase activity”

pyrimidine deoxyribonucleoside binding `http://purl.obolibrary.org/obo/GO_0032548`

Removed

pyrimidine deoxyribonucleoside binding SubClassOf deoxyribonucleoside binding

pyrimidine deoxyribonucleoside diphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009197`

Removed

pyrimidine deoxyribonucleoside diphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine deoxyribonucleoside diphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine deoxyribonucleoside diphosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009198`

Removed

pyrimidine deoxyribonucleoside diphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine deoxyribonucleoside diphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine deoxyribonucleoside diphosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009196`

Removed

pyrimidine deoxyribonucleoside diphosphate metabolic process definition “The chemical reactions and pathways involving pyrimidine deoxynucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine deoxyribonucleoside diphosphate metabolic process definition “The chemical reactions and pathways involving pyrimidine deoxynucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine deoxyribonucleoside monophosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009177`

Removed

pyrimidine deoxyribonucleoside monophosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine deoxyribonucleoside monophosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine deoxyribonucleoside monophosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009178`

Removed

pyrimidine deoxyribonucleoside monophosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine deoxyribonucleoside monophosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine deoxyribonucleoside monophosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009176`

Removed

pyrimidine deoxyribonucleoside monophosphate metabolic process definition “The chemical reactions and pathways involving pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine deoxyribonucleoside monophosphate metabolic process definition “The chemical reactions and pathways involving pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine deoxyribonucleoside triphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009212`

Removed

pyrimidine deoxyribonucleoside triphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine deoxyribonucleoside triphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine deoxyribonucleoside triphosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009213`

Removed

pyrimidine deoxyribonucleoside triphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine deoxyribonucleoside triphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine deoxyribonucleoside triphosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009211`

Removed

pyrimidine deoxyribonucleoside triphosphate metabolic process definition “The chemical reactions and pathways involving pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine deoxyribonucleoside triphosphate metabolic process definition “The chemical reactions and pathways involving pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine deoxyribonucleotide binding `http://purl.obolibrary.org/obo/GO_0032556`

Removed

pyrimidine deoxyribonucleotide binding SubClassOf deoxyribonucleotide binding

Added

pyrimidine deoxyribonucleotide binding SubClassOf carbohydrate derivative binding

pyrimidine deoxyribonucleotide biosynthetic process `http://purl.obolibrary.org/obo/GO_0009221`

Removed

pyrimidine deoxyribonucleotide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine deoxyribonucleotide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine deoxyribonucleotide catabolic process `http://purl.obolibrary.org/obo/GO_0009223`

Removed

pyrimidine deoxyribonucleotide catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”
pyrimidine deoxyribonucleotide catabolic process SubClassOf deoxyribonucleotide catabolic process

Added

pyrimidine deoxyribonucleotide catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine deoxyribonucleotide metabolic process `http://purl.obolibrary.org/obo/GO_0009219`

Removed

pyrimidine deoxyribonucleotide metabolic process definition “The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine deoxyribonucleotide metabolic process definition “The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine nucleobase binding `http://purl.obolibrary.org/obo/GO_0002061`

Removed

pyrimidine nucleobase binding has_exact_synonym “pyrimidine base binding”
- database_cross_reference “GOC:go_curators”

Added

pyrimidine nucleobase binding has_exact_synonym “pyrimidine base binding”
- database_cross_reference “GOC:curators”

pyrimidine nucleobase biosynthetic process `http://purl.obolibrary.org/obo/GO_0019856`

Removed

pyrimidine nucleobase biosynthetic process has_exact_synonym “pyrimidine base biosynthetic process”
- database_cross_reference “GOC:go_curators”
pyrimidine nucleobase biosynthetic process definition “The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.”
- database_cross_reference “GOC:go_curators”

Added

pyrimidine nucleobase biosynthetic process definition “The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.”
- database_cross_reference “GOC:curators”
pyrimidine nucleobase biosynthetic process has_exact_synonym “pyrimidine base biosynthetic process”
- database_cross_reference “GOC:curators”

pyrimidine nucleobase catabolic process `http://purl.obolibrary.org/obo/GO_0006208`

Removed

pyrimidine nucleobase catabolic process has_exact_synonym “pyrimidine base catabolic process”
- database_cross_reference “GOC:go_curators”
pyrimidine nucleobase catabolic process definition “The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.”
- database_cross_reference “GOC:go_curators”

Added

pyrimidine nucleobase catabolic process definition “The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.”
- database_cross_reference “GOC:curators”
pyrimidine nucleobase catabolic process has_exact_synonym “pyrimidine base catabolic process”
- database_cross_reference “GOC:curators”

pyrimidine nucleobase metabolic process `http://purl.obolibrary.org/obo/GO_0006206`

Removed

pyrimidine nucleobase metabolic process definition “The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.”
- database_cross_reference “GOC:go_curators”
pyrimidine nucleobase metabolic process has_exact_synonym “pyrimidine base metabolic process”
- database_cross_reference “GOC:go_curators”

Added

pyrimidine nucleobase metabolic process has_exact_synonym “pyrimidine base metabolic process”
- database_cross_reference “GOC:curators”
pyrimidine nucleobase metabolic process definition “The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.”
- database_cross_reference “GOC:curators”

pyrimidine nucleobase salvage `http://purl.obolibrary.org/obo/GO_0043100`

Removed

pyrimidine nucleobase salvage has_exact_synonym “pyrimidine base salvage”
- database_cross_reference “GOC:go_curators”

Added

pyrimidine nucleobase salvage has_exact_synonym “pyrimidine base salvage”
- database_cross_reference “GOC:curators”

pyrimidine nucleobase transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0005350`

Removed

pyrimidine nucleobase transmembrane transporter activity has_exact_synonym “pyrimidine base transmembrane transporter activity”
- database_cross_reference “GOC:go_curators”

Added

pyrimidine nucleobase transmembrane transporter activity has_exact_synonym “pyrimidine base transmembrane transporter activity”
- database_cross_reference “GOC:curators”

pyrimidine nucleobase transport `http://purl.obolibrary.org/obo/GO_0015855`

Removed

pyrimidine nucleobase transport has_exact_synonym “pyrimidine base transport”
- database_cross_reference “GOC:go_curators”

Added

pyrimidine nucleobase transport has_exact_synonym “pyrimidine base transport”
- database_cross_reference “GOC:curators”

pyrimidine nucleoside diphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009139`

Removed

pyrimidine nucleoside diphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine nucleoside diphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine nucleoside diphosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009140`

Removed

pyrimidine nucleoside diphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine nucleoside diphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine nucleoside diphosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009138`

Removed

pyrimidine nucleoside diphosphate metabolic process definition “The chemical reactions and pathways involving pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine nucleoside diphosphate metabolic process definition “The chemical reactions and pathways involving pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine nucleoside monophosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009130`

Removed

pyrimidine nucleoside monophosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine nucleoside monophosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine nucleoside monophosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009131`

Removed

pyrimidine nucleoside monophosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine nucleoside monophosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine nucleoside monophosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009129`

Removed

pyrimidine nucleoside monophosphate metabolic process definition “The chemical reactions and pathways involving pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine nucleoside monophosphate metabolic process definition “The chemical reactions and pathways involving pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine nucleoside triphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009148`

Removed

pyrimidine nucleoside triphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine nucleoside triphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine nucleoside triphosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009149`

Removed

pyrimidine nucleoside triphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine nucleoside triphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine nucleoside triphosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009147`

Removed

pyrimidine nucleoside triphosphate metabolic process definition “The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine nucleoside triphosphate metabolic process definition “The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine nucleotide biosynthetic process `http://purl.obolibrary.org/obo/GO_0006221`

Removed

pyrimidine nucleotide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine nucleotide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine nucleotide catabolic process `http://purl.obolibrary.org/obo/GO_0006244`

Removed

pyrimidine nucleotide catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine nucleotide catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine nucleotide import into mitochondrion `http://purl.obolibrary.org/obo/GO_1990519`

Added

pyrimidine nucleotide import into mitochondrion SubClassOf intercellular transport

pyrimidine nucleotide metabolic process `http://purl.obolibrary.org/obo/GO_0006220`

Removed

pyrimidine nucleotide metabolic process definition “The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine nucleotide metabolic process definition “The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine nucleotide transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015218`

Added

pyrimidine nucleotide transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9940804”
- label “SLC35A1,4 import CDP-ribitol”

pyrimidine ribonucleoside diphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009194`

Removed

pyrimidine ribonucleoside diphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine ribonucleoside diphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine ribonucleoside diphosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009195`

Removed

pyrimidine ribonucleoside diphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine ribonucleoside diphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine ribonucleoside diphosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009193`

Removed

pyrimidine ribonucleoside diphosphate metabolic process definition “The chemical reactions and pathways involving pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine ribonucleoside diphosphate metabolic process definition “The chemical reactions and pathways involving pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine ribonucleoside monophosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009174`

Removed

pyrimidine ribonucleoside monophosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine ribonucleoside monophosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine ribonucleoside monophosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009175`

Removed

pyrimidine ribonucleoside monophosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine ribonucleoside monophosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine ribonucleoside monophosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009173`

Removed

pyrimidine ribonucleoside monophosphate metabolic process definition “The chemical reactions and pathways involving pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine ribonucleoside monophosphate metabolic process definition “The chemical reactions and pathways involving pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine ribonucleoside triphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009209`

Removed

pyrimidine ribonucleoside triphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine ribonucleoside triphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine ribonucleoside triphosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009210`

Removed

pyrimidine ribonucleoside triphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine ribonucleoside triphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine ribonucleoside triphosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009208`

Removed

pyrimidine ribonucleoside triphosphate metabolic process definition “The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine ribonucleoside triphosphate metabolic process definition “The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine ribonucleotide biosynthetic process `http://purl.obolibrary.org/obo/GO_0009220`

Removed

pyrimidine ribonucleotide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine ribonucleotide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine ribonucleotide catabolic process `http://purl.obolibrary.org/obo/GO_0009222`

Removed

pyrimidine ribonucleotide catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine ribonucleotide catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine ribonucleotide metabolic process `http://purl.obolibrary.org/obo/GO_0009218`

Removed

pyrimidine ribonucleotide metabolic process definition “The chemical reactions and pathways involving a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

pyrimidine ribonucleotide metabolic process definition “The chemical reactions and pathways involving a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

pyrimidine-5’-nucleotide nucleosidase activity `http://purl.obolibrary.org/obo/GO_0047405`

Added

pyrithiamine deaminase activity `http://purl.obolibrary.org/obo/GO_0050239`

Removed

pyrithiamine deaminase activity definition “Catalysis of the reaction: 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + NH3.”
- database_cross_reference “MetaCyc:PYRITHIAMIN-DEAMINASE-RXN”
- database_cross_reference “EC:3.5.4.20”

Added

pyrithiamine deaminase activity definition “Catalysis of the reaction: 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H2O + H+ = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4+.”
- database_cross_reference “RHEA:14537”

pyroptotic inflammatory response `http://purl.obolibrary.org/obo/GO_0070269`

Added

pyroptotic inflammatory response database_cross_reference “Reactome:R-HSA-9960519”
- label “CASP4-mediated substrate cleavage”
pyroptotic inflammatory response database_cross_reference “Reactome:R-HSA-9960525”
- label “CASP5-mediated substrate cleavage”

pyrroline-5-carboxylate reductase activity `http://purl.obolibrary.org/obo/GO_0004735`

Removed

pyrroline-5-carboxylate reductase activity database_cross_reference “Reactome:R-HSA-6783955”
- label “PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro”

Added

pyrroline-5-carboxylate reductase activity database_cross_reference “Reactome:R-HSA-6783955”
- label “PYCR3 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro”

pyrrolysine biosynthetic process `http://purl.obolibrary.org/obo/GO_0071524`

Removed

pyrrolysine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of pyrrolysine, N6-{[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl}-L-lysine.”
- database_cross_reference “PMID:17204561”
- database_cross_reference “GOC:dh”

Added

pyrrolysine biosynthetic process database_cross_reference “MetaCyc:PWY-6994”
pyrrolysine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of pyrrolysine.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:17204561”
pyrrolysine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31510”^^anyURI

pyruvate biosynthetic process `http://purl.obolibrary.org/obo/GO_0042866`

Removed

pyruvate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate.”
- database_cross_reference “GOC:go_curators”

Added

pyruvate biosynthetic process database_cross_reference “Reactome:R-HSA-70268”
- label “Pyruvate metabolism”
pyruvate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate.”
- database_cross_reference “GOC:curators”

pyruvate biosynthetic process from acetate `http://purl.obolibrary.org/obo/GO_0019687`

Removed

pyruvate biosynthetic process from acetate definition “The chemical reactions and pathways resulting in the formation of pyruvate from other compounds, including acetate.”
- database_cross_reference “GOC:go_curators”

Added

pyruvate biosynthetic process from acetate definition “The chemical reactions and pathways resulting in the formation of pyruvate from other compounds, including acetate.”
- database_cross_reference “GOC:curators”

pyruvate catabolic process `http://purl.obolibrary.org/obo/GO_0042867`

Removed

pyruvate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of pyruvate, 2-oxopropanoate.”
- database_cross_reference “GOC:go_curators”

Added

pyruvate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of pyruvate, 2-oxopropanoate.”
- database_cross_reference “GOC:curators”

pyruvate decarboxylase activity `http://purl.obolibrary.org/obo/GO_0004737`

Added

pyruvate decarboxylase activity narrowMatch 50312
pyruvate decarboxylase activity database_cross_reference “RHEA:45484”
pyruvate decarboxylase activity database_cross_reference “RHEA:54356”
pyruvate decarboxylase activity database_cross_reference “RHEA:54360”
pyruvate decarboxylase activity narrowMatch 45484
pyruvate decarboxylase activity narrowMatch 55072
pyruvate decarboxylase activity narrowMatch 54356
pyruvate decarboxylase activity database_cross_reference “RHEA:55072”
pyruvate decarboxylase activity narrowMatch 54360
pyruvate decarboxylase activity database_cross_reference “RHEA:50312”

pyruvate decarboxylation to acetyl-CoA `http://purl.obolibrary.org/obo/GO_0006086`

Added

pyruvate decarboxylation to acetyl-CoA database_cross_reference “MetaCyc:PWY-8275”
pyruvate decarboxylation to acetyl-CoA database_cross_reference “MetaCyc:PWY-6970”
pyruvate decarboxylation to acetyl-CoA term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
pyruvate decarboxylation to acetyl-CoA narrowMatch PYRUVDEHYD-PWY
pyruvate decarboxylation to acetyl-CoA narrowMatch PWY-6970
pyruvate decarboxylation to acetyl-CoA narrowMatch PWY-8275

pyruvate fermentation `http://purl.obolibrary.org/obo/GO_0019660`

Removed

pyruvate fermentation database_cross_reference “MetaCyc:Pyruvate-Degradation”

Added

pyruvate fermentation term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
pyruvate fermentation term tracker item “https://github.com/geneontology/go-ontology/issues/31679”^^anyURI

pyruvate fermentation to D(-)-lactate `http://purl.obolibrary.org/obo/GO_0019245`

Removed

pyruvate fermentation to D(-)-lactate definition “The chemical reactions and pathways resulting in the formation of D(-)-lactate from other compounds, including pyruvate.”
- database_cross_reference “GOC:go_curators”
pyruvate fermentation to D(-)-lactate label “D(-)-lactate biosynthetic process from pyruvate”
pyruvate fermentation to D(-)-lactate SubClassOf has part some D-lactate dehydrogenase (NAD+) activity

Added

pyruvate fermentation to D(-)-lactate label “pyruvate fermentation to D(-)-lactate”
pyruvate fermentation to D(-)-lactate database_cross_reference “MetaCyc:PWY-8274”
pyruvate fermentation to D(-)-lactate term tracker item “https://github.com/geneontology/go-ontology/issues/31679”^^anyURI
pyruvate fermentation to D(-)-lactate definition “The chemical reactions and pathways resulting in the formation of D(-)-lactate from other compounds, including pyruvate.”
- database_cross_reference “GOC:curators”
pyruvate fermentation to D(-)-lactate has_exact_synonym “D(-)-lactate biosynthetic process from pyruvate”

pyruvate fermentation to L(+)-lactate `http://purl.obolibrary.org/obo/GO_0019246`

Removed

pyruvate fermentation to L(+)-lactate label “L(+)-lactate biosynthetic process from pyruvate”
pyruvate fermentation to L(+)-lactate definition “The chemical reactions and pathways resulting in the formation of L(+)-lactate from other compounds, including pyruvate.”
- database_cross_reference “GOC:go_curators”
pyruvate fermentation to L(+)-lactate SubClassOf has part some L-lactate dehydrogenase (NAD+) activity

Added

pyruvate fermentation to L(+)-lactate has_exact_synonym “L(+)-lactate biosynthetic process from pyruvate”
pyruvate fermentation to L(+)-lactate label “pyruvate fermentation to L(+)-lactate”
pyruvate fermentation to L(+)-lactate definition “The chemical reactions and pathways resulting in the formation of L(+)-lactate from other compounds, including pyruvate.”
- database_cross_reference “GOC:curators”
pyruvate fermentation to L(+)-lactate term tracker item “https://github.com/geneontology/go-ontology/issues/31679”^^anyURI

pyruvate fermentation to acetate `http://purl.obolibrary.org/obo/GO_0019654`

Added

pyruvate fermentation to acetate narrowMatch PWY-5485
pyruvate fermentation to acetate narrowMatch PWY-5600
pyruvate fermentation to acetate database_cross_reference “MetaCyc:PWY-5768”
pyruvate fermentation to acetate term tracker item “https://github.com/geneontology/go-ontology/issues/31679”^^anyURI
pyruvate fermentation to acetate database_cross_reference “MetaCyc:PWY-5537”
pyruvate fermentation to acetate narrowMatch PWY-5482
pyruvate fermentation to acetate database_cross_reference “MetaCyc:PWY-5482”
pyruvate fermentation to acetate narrowMatch PWY-5538
pyruvate fermentation to acetate narrowMatch PWY-5483
pyruvate fermentation to acetate narrowMatch P142-PWY
pyruvate fermentation to acetate narrowMatch PWY-5768
pyruvate fermentation to acetate database_cross_reference “MetaCyc:PWY-5485”
pyruvate fermentation to acetate database_cross_reference “MetaCyc:PWY-5600”
pyruvate fermentation to acetate database_cross_reference “MetaCyc:PWY-5538”
pyruvate fermentation to acetate database_cross_reference “MetaCyc:PWY-5483”
pyruvate fermentation to acetate narrowMatch PWY-5537

pyruvate fermentation to butanoate `http://purl.obolibrary.org/obo/GO_0044813`

Removed

pyruvate fermentation to butanoate label “pyruvate fermentation via PFOR”
pyruvate fermentation to butanoate definition “The anaerobic chemical reactions and pathways resulting in the breakdown of pyruvate via pyruvate:ferredoxin oxidoreductase (PFOR) activity. This pathway is found in strict anaerobes such as Clostridia species.”
- database_cross_reference “PMID:20395274”
- database_cross_reference “PMID:20692761”
- database_cross_reference “GOC:mengo_curators”
pyruvate fermentation to butanoate EquivalentTo pyruvate fermentation and (has part some pyruvate synthase activity)
pyruvate fermentation to butanoate SubClassOf has part some pyruvate synthase activity

Added

pyruvate fermentation to butanoate term tracker item “https://github.com/geneontology/go-ontology/issues/31679”^^anyURI
pyruvate fermentation to butanoate definition “The anaerobic chemical reactions and pathways resulting in the breakdown of pyruvate into butanoate. This pathway is found in strict anaerobes such as Clostridia species.”
- database_cross_reference “PMID:20395274”
- database_cross_reference “PMID:20692761”
- database_cross_reference “GOC:mengo_curators”
pyruvate fermentation to butanoate has_exact_synonym “pyruvate fermentation via PFOR”
pyruvate fermentation to butanoate label “pyruvate fermentation to butanoate”
pyruvate fermentation to butanoate SubClassOf butyrate metabolic process

pyruvate fermentation to ethanol `http://purl.obolibrary.org/obo/GO_0019655`

Removed

pyruvate fermentation to ethanol database_cross_reference “MetaCyc:Pyruvate-Ethanol-Fermentation”

Added

pyruvate fermentation to ethanol narrowMatch PWY-6587
pyruvate fermentation to ethanol database_cross_reference “MetaCyc:PWY-5480”
pyruvate fermentation to ethanol narrowMatch PWY-5486
pyruvate fermentation to ethanol database_cross_reference “MetaCyc:PWY-6587”
pyruvate fermentation to ethanol narrowMatch PWY-5480
pyruvate fermentation to ethanol term tracker item “https://github.com/geneontology/go-ontology/issues/31679”^^anyURI
pyruvate fermentation to ethanol database_cross_reference “MetaCyc:PWY-5486”

pyruvate fermentation to lactate `http://purl.obolibrary.org/obo/GO_0019244`

Removed

pyruvate fermentation to lactate has_exact_synonym “pyruvate fermentation to lactate”
pyruvate fermentation to lactate definition “The chemical reactions and pathways resulting in the formation of lactate from other compounds, including pyruvate.”
- database_cross_reference “GOC:go_curators”
pyruvate fermentation to lactate label “lactate biosynthetic process from pyruvate”
pyruvate fermentation to lactate SubClassOf pyruvate metabolic process
pyruvate fermentation to lactate SubClassOf has part some lactate dehydrogenase activity
pyruvate fermentation to lactate SubClassOf lactate biosynthetic process

Added

pyruvate fermentation to lactate term tracker item “https://github.com/geneontology/go-ontology/issues/31679”^^anyURI
pyruvate fermentation to lactate definition “The anaerobic chemical reactions and pathways resulting in the breakdown of pyruvate into lactate.”
- database_cross_reference “GOC:curators”
pyruvate fermentation to lactate has_exact_synonym “lactate biosynthetic process from pyruvate”
pyruvate fermentation to lactate label “pyruvate fermentation to lactate”
pyruvate fermentation to lactate SubClassOf lactate metabolic process
pyruvate fermentation to lactate SubClassOf pyruvate fermentation

pyruvate kinase activity `http://purl.obolibrary.org/obo/GO_0004743`

Removed

pyruvate kinase activity database_cross_reference “Reactome:R-HSA-71670”
- label “PKM dephosphorylates PEP to PYR”

Added

pyruvate kinase activity database_cross_reference “Reactome:R-HSA-71670”
- label “Pyruvate kinase dephosphorylates PEP to PYR”

pyruvate metabolic process `http://purl.obolibrary.org/obo/GO_0006090`

Removed

pyruvate metabolic process database_cross_reference “MetaCyc:P41-PWY”
pyruvate metabolic process database_cross_reference “Reactome:R-HSA-70268”
- label “Pyruvate metabolism”
pyruvate metabolic process definition “The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.”
- database_cross_reference “GOC:go_curators”

Added

pyruvate metabolic process definition “The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.”
- database_cross_reference “GOC:curators”
pyruvate metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI

queuine transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0160283`

Removed

queuine transmembrane transporter activity definition “Enables the transfer of queuine from one side of a membrane to the other according to the reaction: queuine(out) = queuine(in).”
- database_cross_reference “PMID:40526720”

Added

queuine transmembrane transporter activity exactMatch 85679
queuine transmembrane transporter activity database_cross_reference “RHEA:85679”
queuine transmembrane transporter activity definition “Enables the transfer of queuine from one side of a membrane to the other according to the reaction: queuine(out) = queuine(in).”
- database_cross_reference “PMID:40526720”
- database_cross_reference “RHEA:85679”

queuosine transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0160286`

Removed

queuosine transmembrane transporter activity definition “Enables the transfer of queuosine from one side of a membrane to the other according to the reaction: queuosine(out) = queuosine(in).”
- database_cross_reference “PMID:40526720”

Added

queuosine transmembrane transporter activity definition “Enables the transfer of queuosine from one side of a membrane to the other according to the reaction: queuosine(out) = queuosine(in).”
- database_cross_reference “RHEA:85683”
- database_cross_reference “PMID:40526720”
queuosine transmembrane transporter activity exactMatch 85683
queuosine transmembrane transporter activity database_cross_reference “RHEA:85683”

quinate biosynthetic process `http://purl.obolibrary.org/obo/GO_0042194`

Removed

quinate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of quinate, the anion of quinic acid.”
- database_cross_reference “GOC:go_curators”

Added

quinate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of quinate, the anion of quinic acid.”
- database_cross_reference “GOC:curators”

quinate catabolic process `http://purl.obolibrary.org/obo/GO_0019631`

Added

quinate catabolic process narrowMatch QUINATEDEG-PWY
quinate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
quinate catabolic process database_cross_reference “MetaCyc:PWY-6416”
quinate catabolic process narrowMatch PWY-6416

quinol-cytochrome-c reductase activity `http://purl.obolibrary.org/obo/GO_0008121`

Removed

quinol-cytochrome-c reductase activity SubClassOf has part some oxidoreductase activity, acting on diphenols and related substances as donors

Added

quinol-cytochrome-c reductase activity term tracker item “https://github.com/geneontology/go-ontology/issues/25935”^^anyURI
quinol-cytochrome-c reductase activity SubClassOf oxidoreductase activity, acting on diphenols and related substances as donors

quinone catabolic process `http://purl.obolibrary.org/obo/GO_1901662`

Removed

quinone catabolic process definition “The chemical reactions and pathways resulting in the breakdown of quinone.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “GOC:pr”

Added

quinone catabolic process definition “The chemical reactions and pathways resulting in the breakdown of quinone.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “GOC:pr”

quinone metabolic process `http://purl.obolibrary.org/obo/GO_1901661`

Removed

quinone metabolic process definition “The chemical reactions and pathways involving quinone.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “GOC:pr”

Added

quinone metabolic process definition “The chemical reactions and pathways involving quinone.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “GOC:pr”

rRNA (adenine) methyltransferase activity `http://purl.obolibrary.org/obo/GO_0016433`

Removed

rRNA (adenine) methyltransferase activity definition “Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine.”
- database_cross_reference “GOC:go-curators”

Added

rRNA (adenine) methyltransferase activity definition “Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine.”
- database_cross_reference “GOC:curators”

rRNA (adenine-N6-)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0008988`

Added

rRNA (adenine-N6-)-methyltransferase activity narrowMatch 62612
rRNA (adenine-N6-)-methyltransferase activity database_cross_reference “RHEA:62612”
rRNA (adenine-N6-)-methyltransferase activity narrowMatch 58724
rRNA (adenine-N6-)-methyltransferase activity database_cross_reference “RHEA:58724”

rRNA (cytosine) methyltransferase activity `http://purl.obolibrary.org/obo/GO_0016434`

Removed

rRNA (cytosine) methyltransferase activity definition “Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylcytosine.”
- database_cross_reference “GOC:go-curators”

Added

rRNA (cytosine) methyltransferase activity definition “Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylcytosine.”
- database_cross_reference “GOC:curators”

rRNA (cytosine-2’-O-ribose)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0070677`

Removed

rRNA (cytosine-2’-O-ribose)-methyltransferase activity label “rRNA (cytosine-2’-O-)-methyltransferase activity”

Added

rRNA (cytosine-2’-O-ribose)-methyltransferase activity has_exact_synonym “rRNA (cytosine-2’-O-)-methyltransferase activity”
rRNA (cytosine-2’-O-ribose)-methyltransferase activity label “rRNA (cytosine-2’-O-ribose)-methyltransferase activity”

rRNA (cytosine-N4-)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0071424`

Added

rRNA (guanosine-2’-O-ribose)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0070039`

Removed

rRNA (guanosine-2’-O-ribose)-methyltransferase activity label “rRNA (guanosine-2’-O-)-methyltransferase activity”

Added

rRNA (guanosine-2’-O-ribose)-methyltransferase activity label “rRNA (guanosine-2’-O-ribose)-methyltransferase activity”
rRNA (guanosine-2’-O-ribose)-methyltransferase activity has_exact_synonym “rRNA (guanosine-2’-O-)-methyltransferase activity”

rRNA (uridine) methyltransferase activity `http://purl.obolibrary.org/obo/GO_0016436`

Removed

rRNA (uridine) methyltransferase activity definition “Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyluridine.”
- database_cross_reference “GOC:go-curators”

Added

rRNA (uridine) methyltransferase activity definition “Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyluridine.”
- database_cross_reference “GOC:curators”

rRNA (uridine-2’-O-ribose)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0008650`

Removed

rRNA (uridine-2’-O-ribose)-methyltransferase activity label “rRNA (uridine-2’-O-)-methyltransferase activity”

Added

rRNA (uridine-2’-O-ribose)-methyltransferase activity label “rRNA (uridine-2’-O-ribose)-methyltransferase activity”
rRNA (uridine-2’-O-ribose)-methyltransferase activity database_cross_reference “RHEA:47760”
rRNA (uridine-2’-O-ribose)-methyltransferase activity narrowMatch 47760
rRNA (uridine-2’-O-ribose)-methyltransferase activity narrowMatch 42720
rRNA (uridine-2’-O-ribose)-methyltransferase activity has_exact_synonym “rRNA (uridine-2’-O-)-methyltransferase activity”
rRNA (uridine-2’-O-ribose)-methyltransferase activity database_cross_reference “RHEA:43092”
rRNA (uridine-2’-O-ribose)-methyltransferase activity narrowMatch 43092
rRNA (uridine-2’-O-ribose)-methyltransferase activity database_cross_reference “RHEA:47764”
rRNA (uridine-2’-O-ribose)-methyltransferase activity database_cross_reference “RHEA:42720”
rRNA (uridine-2’-O-ribose)-methyltransferase activity narrowMatch 47764

rRNA methyltransferase activity `http://purl.obolibrary.org/obo/GO_0008649`

Removed

rRNA methyltransferase activity definition “Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule.”
- database_cross_reference “GOC:mah”

Added

rRNA methyltransferase activity database_cross_reference “Reactome:R-HSA-9911509”
- label “RMTases methylate 16S ribosomal RNA”
rRNA methyltransferase activity definition “Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. The methyl group can be transfered to the nucleobase or to the ribose group of the nucleoside.”
- database_cross_reference “GOC:mah”

rRNA pseudouridine synthase activity `http://purl.obolibrary.org/obo/GO_0120159`

Added

rRNA pseudouridine synthase activity narrowMatch 47036
rRNA pseudouridine synthase activity database_cross_reference “RHEA:47036”

rRNA small subunit aminocarboxypropyltransferase activity `http://purl.obolibrary.org/obo/GO_0106388`

Added

radial axis specification `http://purl.obolibrary.org/obo/GO_0009945`

Removed

radial axis specification definition “The establishment, maintenance and elaboration of an axis that initiates at a point and radiates outward from the point.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:isa_complete”
- database_cross_reference “GOC:go_curators”

Added

radial axis specification definition “The establishment, maintenance and elaboration of an axis that initiates at a point and radiates outward from the point.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:isa_complete”

radial pattern formation `http://purl.obolibrary.org/obo/GO_0009956`

Removed

radial pattern formation definition “The regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:isa_complete”
- database_cross_reference “GOC:go_curators”

Added

radial pattern formation definition “The regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:isa_complete”

reactive gliosis `http://purl.obolibrary.org/obo/GO_0150103`

Removed

reactive gliosis definition “A neuroinflammatory response, occurring over several days, during which glial cells undergo nonspecific reactive changes in response to damage to the central nervous system (CNS); typically involves the proliferation or hypertrophy of different types of glial cells.”
- database_cross_reference “PMID:24462092”
- database_cross_reference “GOC:bc”
- database_cross_reference “GOC:aruk”

Added

reactive gliosis definition “A coordinated response of central nervous system (CNS) glial cells-including astrocytes, microglia, and NG2 glia-to injury, infection, or disease, characterized by changes in gene expression, morphology, proliferation, and extracellular matrix production. Reactive gliosis can range from transient glial activation to the formation of a persistent glial scar border.”
- database_cross_reference “PMID:20012068”
- database_cross_reference “PMID:24462092”
- database_cross_reference “PMID:27049947”
- database_cross_reference “GOC:bc”
- database_cross_reference “PMID:24267886”
- database_cross_reference “GOC:aruk”
reactive gliosis term tracker item “https://github.com/geneontology/go-ontology/issues/30886”^^anyURI

receptor ligand activity `http://purl.obolibrary.org/obo/GO_0048018`

Removed

receptor ligand activity database_cross_reference “Reactome:R-HSA-163625”
- label “Glucagon binds to Glucagon receptor”

Added

receptor ligand activity database_cross_reference “Reactome:R-HSA-8848663”
- label “ADIPOQ trimer binds ADIPOR dimers”

recombination within rDNA repeats `http://purl.obolibrary.org/obo/GO_0045458`

Removed

recombination within rDNA repeats definition “Genetic recombination within the DNA of the genes coding for ribosomal RNA.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

recombination within rDNA repeats definition “Genetic recombination within the DNA of the genes coding for ribosomal RNA.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

reelin complex `http://purl.obolibrary.org/obo/GO_0110157`

Removed

reelin complex SubClassOf protein-containing complex
reelin complex SubClassOf part of some obsolete extracellular space

Added

reelin complex SubClassOf extracellular protein-containing complex

regulation of ‘de novo’ NAD biosynthetic process from L-tryptophan `http://purl.obolibrary.org/obo/GO_1905012`

Removed

regulation of ‘de novo’ NAD biosynthetic process from L-tryptophan SubClassOf obsolete regulation of L-tryptophan metabolic process

Added

regulation of ‘de novo’ NAD biosynthetic process from L-tryptophan SubClassOf regulation of amino acid metabolic process

regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_1902646`

Removed

regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process SubClassOf regulation of phosphatidylinositol biosynthetic process

Added

regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process SubClassOf regulation of phospholipid biosynthetic process

regulation of B cell differentiation `http://purl.obolibrary.org/obo/GO_0045577`

Removed

regulation of B cell differentiation definition “Any process that modulates the frequency, rate or extent of B cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of B cell differentiation definition “Any process that modulates the frequency, rate or extent of B cell differentiation.”
- database_cross_reference “GOC:curators”

regulation of DNA recombination `http://purl.obolibrary.org/obo/GO_0000018`

Removed

regulation of DNA recombination definition “Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

regulation of DNA recombination definition “Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

regulation of DNA repair `http://purl.obolibrary.org/obo/GO_0006282`

Removed

regulation of DNA repair definition “Any process that modulates the frequency, rate or extent of DNA repair.”
- database_cross_reference “GOC:go_curators”

Added

regulation of DNA repair definition “Any process that modulates the frequency, rate or extent of DNA repair.”
- database_cross_reference “GOC:curators”

regulation of DNA replication `http://purl.obolibrary.org/obo/GO_0006275`

Removed

regulation of DNA replication definition “Any process that modulates the frequency, rate or extent of DNA replication.”
- database_cross_reference “GOC:go_curators”

Added

regulation of DNA replication definition “Any process that modulates the frequency, rate or extent of DNA replication.”
- database_cross_reference “GOC:curators”

regulation of DNA-templated transcription `http://purl.obolibrary.org/obo/GO_0006355`

Removed

regulation of DNA-templated transcription definition “Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:txnOH”

Added

regulation of DNA-templated transcription definition “Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:txnOH”
regulation of DNA-templated transcription database_cross_reference “Reactome:R-HSA-9708530”
- label “Regulation of BACH1 activity”

regulation of G protein-coupled receptor signaling pathway `http://purl.obolibrary.org/obo/GO_0008277`

Removed

regulation of G protein-coupled receptor signaling pathway definition “Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.”
- database_cross_reference “GOC:go_curators”

Added

regulation of G protein-coupled receptor signaling pathway definition “Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.”
- database_cross_reference “GOC:curators”

regulation of GABA catabolic process `http://purl.obolibrary.org/obo/GO_1901715`

Removed

regulation of GABA catabolic process label “regulation of gamma-aminobutyric acid catabolic process”
regulation of GABA catabolic process has_exact_synonym “regulation of GABA catabolic process”
- database_cross_reference “GOC:TermGenie”

Added

regulation of GABA catabolic process has_exact_synonym “regulation of gamma-aminobutyric acid catabolic process”
- database_cross_reference “GOC:TermGenie”
regulation of GABA catabolic process label “regulation of GABA catabolic process”

regulation of L-fucose catabolic process `http://purl.obolibrary.org/obo/GO_0043468`

Removed

regulation of L-fucose catabolic process label “regulation of fucose catabolic process”
regulation of L-fucose catabolic process definition “Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of fucose.”
- database_cross_reference “GOC:mlg”
regulation of L-fucose catabolic process EquivalentTo biological regulation and (regulates some obsolete fucose catabolic process)
regulation of L-fucose catabolic process SubClassOf regulates some obsolete fucose catabolic process

Added

regulation of L-fucose catabolic process label “regulation of L-fucose catabolic process”
regulation of L-fucose catabolic process definition “Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of L-fucose.”
- database_cross_reference “GOC:mlg”
regulation of L-fucose catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31652”^^anyURI
regulation of L-fucose catabolic process has_related_synonym “regulation of fucose catabolic process”
regulation of L-fucose catabolic process EquivalentTo biological regulation and (regulates some L-fucose catabolic process)
regulation of L-fucose catabolic process SubClassOf regulates some L-fucose catabolic process

regulation of L-proline biosynthetic process `http://purl.obolibrary.org/obo/GO_1902005`

Removed

regulation of L-proline biosynthetic process SubClassOf obsolete regulation of L-proline metabolic process

Added

regulation of L-proline biosynthetic process SubClassOf regulation of small molecule metabolic process

regulation of L-proline catabolic process `http://purl.obolibrary.org/obo/GO_2001156`

Removed

regulation of L-proline catabolic process SubClassOf obsolete regulation of L-proline metabolic process

Added

regulation of MAP kinase activity `http://purl.obolibrary.org/obo/GO_0043405`

Removed

regulation of MAP kinase activity definition “Any process that modulates the frequency, rate or extent of MAP kinase activity.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”

Added

regulation of MAP kinase activity definition “Any process that modulates the frequency, rate or extent of MAP kinase activity.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”

regulation of MAPK cascade `http://purl.obolibrary.org/obo/GO_0043408`

Removed

regulation of MAPK cascade definition “Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.”
- database_cross_reference “GOC:go_curators”

Added

regulation of MAPK cascade definition “Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.”
- database_cross_reference “GOC:curators”

regulation of MHC class I biosynthetic process `http://purl.obolibrary.org/obo/GO_0045343`

Removed

regulation of MHC class I biosynthetic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I.”
- database_cross_reference “GOC:go_curators”

Added

regulation of MHC class I biosynthetic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I.”
- database_cross_reference “GOC:curators”

regulation of MHC class II biosynthetic process `http://purl.obolibrary.org/obo/GO_0045346`

Removed

regulation of MHC class II biosynthetic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II.”
- database_cross_reference “GOC:go_curators”

Added

regulation of MHC class II biosynthetic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II.”
- database_cross_reference “GOC:curators”

regulation of Notch signaling pathway `http://purl.obolibrary.org/obo/GO_0008593`

Removed

regulation of Notch signaling pathway definition “Any process that modulates the frequency, rate or extent of the Notch signaling pathway.”
- database_cross_reference “GOC:go_curators”

Added

regulation of Notch signaling pathway definition “Any process that modulates the frequency, rate or extent of the Notch signaling pathway.”
- database_cross_reference “GOC:curators”

regulation of R7 cell differentiation `http://purl.obolibrary.org/obo/GO_0045676`

Removed

regulation of R7 cell differentiation definition “Any process that modulates the frequency, rate or extent of R7 differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of R7 cell differentiation definition “Any process that modulates the frequency, rate or extent of R7 differentiation.”
- database_cross_reference “GOC:curators”

regulation of R8 cell differentiation `http://purl.obolibrary.org/obo/GO_0045679`

Removed

regulation of R8 cell differentiation definition “Any process that modulates the frequency, rate or extent of R8 differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of R8 cell differentiation definition “Any process that modulates the frequency, rate or extent of R8 differentiation.”
- database_cross_reference “GOC:curators”

regulation of RNA polymerase II transcription preinitiation complex assembly `http://purl.obolibrary.org/obo/GO_0045898`

Removed

regulation of RNA polymerase II transcription preinitiation complex assembly definition “Any process that modulates the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.”
- database_cross_reference “GOC:go_curators”

Added

regulation of RNA polymerase II transcription preinitiation complex assembly definition “Any process that modulates the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.”
- database_cross_reference “GOC:curators”

regulation of T cell differentiation `http://purl.obolibrary.org/obo/GO_0045580`

Removed

regulation of T cell differentiation definition “Any process that modulates the frequency, rate or extent of T cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of T cell differentiation definition “Any process that modulates the frequency, rate or extent of T cell differentiation.”
- database_cross_reference “GOC:curators”

regulation of T cell homeostatic proliferation `http://purl.obolibrary.org/obo/GO_0046013`

Removed

regulation of T cell homeostatic proliferation definition “Any process that modulates the frequency, rate or extent of resting T cell proliferation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of T cell homeostatic proliferation definition “Any process that modulates the frequency, rate or extent of resting T cell proliferation.”
- database_cross_reference “GOC:curators”

regulation of T-helper 1 cell differentiation `http://purl.obolibrary.org/obo/GO_0045625`

Removed

regulation of T-helper 1 cell differentiation definition “Any process that modulates the frequency, rate or extent of T-helper 1 cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of T-helper 1 cell differentiation definition “Any process that modulates the frequency, rate or extent of T-helper 1 cell differentiation.”
- database_cross_reference “GOC:curators”

regulation of T-helper 2 cell differentiation `http://purl.obolibrary.org/obo/GO_0045628`

Removed

regulation of T-helper 2 cell differentiation definition “Any process that modulates the frequency, rate or extent of T-helper 2 cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of T-helper 2 cell differentiation definition “Any process that modulates the frequency, rate or extent of T-helper 2 cell differentiation.”
- database_cross_reference “GOC:curators”

regulation of T-helper cell differentiation `http://purl.obolibrary.org/obo/GO_0045622`

Removed

regulation of T-helper cell differentiation definition “Any process that modulates the frequency, rate or extent of T-helper cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of T-helper cell differentiation definition “Any process that modulates the frequency, rate or extent of T-helper cell differentiation.”
- database_cross_reference “GOC:curators”

regulation of Toll signaling pathway `http://purl.obolibrary.org/obo/GO_0008592`

Removed

regulation of Toll signaling pathway definition “Any process that modulates the frequency, rate or extent of the Tl signaling pathway.”
- database_cross_reference “GOC:go_curators”

Added

regulation of Toll signaling pathway definition “Any process that modulates the frequency, rate or extent of the Tl signaling pathway.”
- database_cross_reference “GOC:curators”

regulation of Wnt signaling pathway, calcium modulating pathway `http://purl.obolibrary.org/obo/GO_0008591`

Removed

regulation of Wnt signaling pathway, calcium modulating pathway definition “Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

regulation of Wnt signaling pathway, calcium modulating pathway definition “Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

regulation of acetate catabolic process `http://purl.obolibrary.org/obo/GO_0045734`

Removed

regulation of acetate catabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid.”
- database_cross_reference “GOC:go_curators”

Added

regulation of acetate catabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid.”
- database_cross_reference “GOC:curators”

regulation of action potential `http://purl.obolibrary.org/obo/GO_0098900`

Removed

regulation of action potential definition “Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”
- database_cross_reference “ISBN:978-0-07-139011-8”

Added

regulation of action potential definition “Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:dos”
- database_cross_reference “GOC:tb”
- database_cross_reference “ISBN:978-0-07-139011-8”

regulation of activated T cell proliferation `http://purl.obolibrary.org/obo/GO_0046006`

Removed

regulation of activated T cell proliferation definition “Any process that modulates the frequency, rate or extent of activated T cell proliferation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of activated T cell proliferation definition “Any process that modulates the frequency, rate or extent of activated T cell proliferation.”
- database_cross_reference “GOC:curators”

regulation of adenylate cyclase activity `http://purl.obolibrary.org/obo/GO_0045761`

Removed

regulation of adenylate cyclase activity definition “Any process that modulates the frequency, rate or extent of adenylate cyclase activity.”
- database_cross_reference “GOC:go_curators”

Added

regulation of adenylate cyclase activity definition “Any process that modulates the frequency, rate or extent of adenylate cyclase activity.”
- database_cross_reference “GOC:curators”

regulation of adult salivary gland boundary specification `http://purl.obolibrary.org/obo/GO_0045707`

Removed

regulation of adult salivary gland boundary specification definition “Any process that modulates the frequency, rate or extent of salivary gland determination in an adult organism.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

regulation of adult salivary gland boundary specification definition “Any process that modulates the frequency, rate or extent of salivary gland determination in an adult organism.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

regulation of alcohol biosynthetic process `http://purl.obolibrary.org/obo/GO_1902930`

Added

regulation of alcohol biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31485”^^anyURI

regulation of alcohol catabolic process `http://purl.obolibrary.org/obo/GO_1900419`

Added

regulation of alcohol catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31485”^^anyURI
regulation of alcohol catabolic process in_subset gocheck_do_not_annotate

regulation of amino acid metabolic process `http://purl.obolibrary.org/obo/GO_0006521`

Removed

regulation of amino acid metabolic process database_cross_reference “Reactome:R-HSA-350562”
- label “Regulation of ornithine decarboxylase (ODC)”
regulation of amino acid metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids.”
- database_cross_reference “GOC:go_curators”

Added

regulation of amino acid metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids.”
- database_cross_reference “GOC:curators”

regulation of ammonia assimilation cycle `http://purl.obolibrary.org/obo/GO_2001248`

Removed

regulation of ammonia assimilation cycle SubClassOf obsolete regulation of glutamate metabolic process

Added

regulation of amyloid precursor protein biosynthetic process `http://purl.obolibrary.org/obo/GO_0042984`

Removed

regulation of amyloid precursor protein biosynthetic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.”
- database_cross_reference “GOC:go_curators”

Added

regulation of amyloid precursor protein biosynthetic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.”
- database_cross_reference “GOC:curators”

regulation of angiogenesis `http://purl.obolibrary.org/obo/GO_0045765`

Removed

regulation of angiogenesis definition “Any process that modulates the frequency, rate or extent of angiogenesis.”
- database_cross_reference “GOC:go_curators”

Added

regulation of angiogenesis definition “Any process that modulates the frequency, rate or extent of angiogenesis.”
- database_cross_reference “GOC:curators”

regulation of antipodal cell differentiation `http://purl.obolibrary.org/obo/GO_0045688`

Removed

regulation of antipodal cell differentiation definition “Any process that modulates the frequency, rate or extent of antipodal cell differentiation.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_plant”

Added

regulation of antipodal cell differentiation definition “Any process that modulates the frequency, rate or extent of antipodal cell differentiation.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_plant”

regulation of apoptotic signaling pathway `http://purl.obolibrary.org/obo/GO_2001233`

Added

regulation of apoptotic signaling pathway database_cross_reference “Reactome:R-HSA-205025”
- label “NADE modulates death signalling”

regulation of axon extension `http://purl.obolibrary.org/obo/GO_0030516`

Removed

regulation of axon extension definition “Any process that modulates the rate, direction or extent of axon extension.”
- database_cross_reference “GOC:go_curators”

Added

regulation of axon extension definition “Any process that modulates the rate, direction or extent of axon extension.”
- database_cross_reference “GOC:curators”

regulation of backward locomotion `http://purl.obolibrary.org/obo/GO_0043058`

Removed

regulation of backward locomotion definition “Any process that modulates the speed, mechanical force, or rhythm of the posterior movement of an organism.”
- database_cross_reference “GOC:go_curators”

Added

regulation of backward locomotion definition “Any process that modulates the speed, mechanical force, or rhythm of the posterior movement of an organism.”
- database_cross_reference “GOC:curators”

regulation of basophil differentiation `http://purl.obolibrary.org/obo/GO_0045640`

Removed

regulation of basophil differentiation definition “Any process that modulates the frequency, rate or extent of basophil differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of basophil differentiation definition “Any process that modulates the frequency, rate or extent of basophil differentiation.”
- database_cross_reference “GOC:curators”

regulation of behavior `http://purl.obolibrary.org/obo/GO_0050795`

Removed

regulation of behavior definition “Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:pr”

Added

regulation of behavior definition “Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:pr”

regulation of beta 2 integrin biosynthetic process `http://purl.obolibrary.org/obo/GO_0045115`

Removed

regulation of beta 2 integrin biosynthetic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins.”
- database_cross_reference “GOC:go_curators”

Added

regulation of beta 2 integrin biosynthetic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins.”
- database_cross_reference “GOC:curators”

regulation of biological process `http://purl.obolibrary.org/obo/GO_0050789`

Removed

regulation of biological process definition “Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:ai”

Added

regulation of biological process definition “Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:ai”

regulation of biosynthetic process `http://purl.obolibrary.org/obo/GO_0009889`

Removed

regulation of biosynthetic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.”
- database_cross_reference “GOC:go_curators”

Added

regulation of biosynthetic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.”
- database_cross_reference “GOC:curators”

regulation of blood vessel endothelial cell migration `http://purl.obolibrary.org/obo/GO_0043535`

Removed

regulation of blood vessel endothelial cell migration definition “Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels.”
- database_cross_reference “GOC:go_curators”

Added

regulation of blood vessel endothelial cell migration definition “Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels.”
- database_cross_reference “GOC:curators”

regulation of bone mineralization `http://purl.obolibrary.org/obo/GO_0030500`

Removed

regulation of bone mineralization definition “Any process that modulates the frequency, rate or extent of bone mineralization.”
- database_cross_reference “GOC:go_curators”

Added

regulation of bone mineralization definition “Any process that modulates the frequency, rate or extent of bone mineralization.”
- database_cross_reference “GOC:curators”

regulation of calcium ion-dependent exocytosis `http://purl.obolibrary.org/obo/GO_0017158`

Removed

regulation of calcium ion-dependent exocytosis definition “Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis.”
- database_cross_reference “GOC:go_curators”

Added

regulation of calcium ion-dependent exocytosis definition “Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis.”
- database_cross_reference “GOC:curators”

regulation of carbohydrate metabolic process `http://purl.obolibrary.org/obo/GO_0006109`

Removed

regulation of carbohydrate metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates.”
- database_cross_reference “GOC:go_curators”

Added

regulation of carbohydrate metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates.”
- database_cross_reference “GOC:curators”

regulation of cardioblast cell fate specification `http://purl.obolibrary.org/obo/GO_0042686`

Removed

regulation of cardioblast cell fate specification definition “Any process that mediates the specification of a cell into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.”
- database_cross_reference “GOC:go_curators”

Added

regulation of cardioblast cell fate specification definition “Any process that mediates the specification of a cell into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.”
- database_cross_reference “GOC:curators”

regulation of catabolic process `http://purl.obolibrary.org/obo/GO_0009894`

Removed

regulation of catabolic process definition “Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances.”
- database_cross_reference “GOC:go_curators”

Added

regulation of catabolic process definition “Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances.”
- database_cross_reference “GOC:curators”

regulation of catecholamine metabolic process `http://purl.obolibrary.org/obo/GO_0042069`

Removed

regulation of catecholamine metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines.”
- database_cross_reference “GOC:go_curators”

Added

regulation of catecholamine metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines.”
- database_cross_reference “GOC:curators”

regulation of cell differentiation `http://purl.obolibrary.org/obo/GO_0045595`

Removed

regulation of cell differentiation definition “Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.”
- database_cross_reference “GOC:go_curators”

Added

regulation of cell differentiation definition “Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.”
- database_cross_reference “GOC:curators”

regulation of cell division `http://purl.obolibrary.org/obo/GO_0051302`

Removed

regulation of cell division definition “Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells.”
- database_cross_reference “GOC:go_curators”

Added

regulation of cell division definition “Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells.”
- database_cross_reference “GOC:curators”

regulation of cell fate specification `http://purl.obolibrary.org/obo/GO_0042659`

Removed

regulation of cell fate specification definition “Any process that mediates the adoption of a specific fate by a cell.”
- database_cross_reference “GOC:go_curators”

Added

regulation of cell fate specification definition “Any process that mediates the adoption of a specific fate by a cell.”
- database_cross_reference “GOC:curators”

regulation of cell growth `http://purl.obolibrary.org/obo/GO_0001558`

Removed

regulation of cell growth definition “Any process that modulates the frequency, rate, extent or direction of cell growth.”
- database_cross_reference “GOC:go_curators”

Added

regulation of cell growth definition “Any process that modulates the frequency, rate, extent or direction of cell growth.”
- database_cross_reference “GOC:curators”

regulation of cell migration `http://purl.obolibrary.org/obo/GO_0030334`

Removed

regulation of cell migration definition “Any process that modulates the frequency, rate or extent of cell migration.”
- database_cross_reference “GOC:go_curators”

Added

regulation of cell migration definition “Any process that modulates the frequency, rate or extent of cell migration.”
- database_cross_reference “GOC:curators”

regulation of cell shape `http://purl.obolibrary.org/obo/GO_0008360`

Removed

regulation of cell shape definition “Any process that modulates the surface configuration of a cell.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

regulation of cell shape definition “Any process that modulates the surface configuration of a cell.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

regulation of cell size `http://purl.obolibrary.org/obo/GO_0008361`

Removed

regulation of cell size definition “Any process that modulates the size of a cell.”
- database_cross_reference “GOC:go_curators”

Added

regulation of cell size definition “Any process that modulates the size of a cell.”
- database_cross_reference “GOC:curators”

regulation of cell-cell adhesion mediated by cadherin `http://purl.obolibrary.org/obo/GO_2000047`

Added

regulation of cell-cell adhesion mediated by cadherin database_cross_reference “Reactome:R-HSA-9764274”
- label “Regulation of Expression and Function of Type I Classical Cadherins”

regulation of cellular process `http://purl.obolibrary.org/obo/GO_0050794`

Removed

regulation of cellular process definition “Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.”
- database_cross_reference “GOC:go_curators”

Added

regulation of cellular process definition “Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.”
- database_cross_reference “GOC:curators”

regulation of chitin-based cuticle tanning `http://purl.obolibrary.org/obo/GO_0007564`

Removed

regulation of chitin-based cuticle tanning definition “Any process that modulates the frequency, rate or extent of chitin-based cuticular tanning.”
- database_cross_reference “GOC:jid”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_sensu”

Added

regulation of chitin-based cuticle tanning definition “Any process that modulates the frequency, rate or extent of chitin-based cuticular tanning.”
- database_cross_reference “GOC:jid”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_sensu”

regulation of cholesterol biosynthetic process `http://purl.obolibrary.org/obo/GO_0045540`

Removed

regulation of cholesterol biosynthetic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.”
- database_cross_reference “GOC:go_curators”

Added

regulation of cholesterol biosynthetic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.”
- database_cross_reference “GOC:curators”

regulation of circadian sleep/wake cycle, non-REM sleep `http://purl.obolibrary.org/obo/GO_0045188`

Removed

regulation of circadian sleep/wake cycle, non-REM sleep definition “Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep.”
- database_cross_reference “GOC:go_curators”

Added

regulation of circadian sleep/wake cycle, non-REM sleep definition “Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep.”
- database_cross_reference “GOC:curators”

regulation of complement activation `http://purl.obolibrary.org/obo/GO_0030449`

Removed

regulation of complement activation definition “Any process that modulates the frequency, rate or extent of complement activation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of complement activation definition “Any process that modulates the frequency, rate or extent of complement activation.”
- database_cross_reference “GOC:curators”

regulation of complement activation, alternative pathway `http://purl.obolibrary.org/obo/GO_0030451`

Removed

regulation of complement activation, alternative pathway definition “Any process that modulates the frequency, rate or extent of the alternative pathway of complement activation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of complement activation, alternative pathway definition “Any process that modulates the frequency, rate or extent of the alternative pathway of complement activation.”
- database_cross_reference “GOC:curators”

regulation of complement activation, classical pathway `http://purl.obolibrary.org/obo/GO_0030450`

Removed

regulation of complement activation, classical pathway definition “Any process that modulates the frequency, rate or extent of the classical pathway of complement activation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of complement activation, classical pathway definition “Any process that modulates the frequency, rate or extent of the classical pathway of complement activation.”
- database_cross_reference “GOC:curators”

regulation of corticotropin-releasing hormone secretion `http://purl.obolibrary.org/obo/GO_0043397`

Removed

regulation of corticotropin-releasing hormone secretion definition “Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone secretion.”
- database_cross_reference “PMID:11027914”
- database_cross_reference “GOC:go_curators”

Added

regulation of corticotropin-releasing hormone secretion definition “Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone secretion.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:11027914”

regulation of crystal cell differentiation `http://purl.obolibrary.org/obo/GO_0042689`

Removed

regulation of crystal cell differentiation definition “Any process that modulates the frequency, rate or extent of crystal cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of crystal cell differentiation definition “Any process that modulates the frequency, rate or extent of crystal cell differentiation.”
- database_cross_reference “GOC:curators”

regulation of cumulus cell differentiation `http://purl.obolibrary.org/obo/GO_0045592`

Removed

regulation of cumulus cell differentiation definition “Any process that modulates the frequency, rate or extent of ovarian cumulus cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of cumulus cell differentiation definition “Any process that modulates the frequency, rate or extent of ovarian cumulus cell differentiation.”
- database_cross_reference “GOC:curators”

regulation of cyclin-dependent protein serine/threonine kinase activity `http://purl.obolibrary.org/obo/GO_0000079`

Removed

regulation of cyclin-dependent protein serine/threonine kinase activity definition “Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:pr”

Added

regulation of cyclin-dependent protein serine/threonine kinase activity definition “Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:pr”

regulation of cytochrome-c oxidase activity `http://purl.obolibrary.org/obo/GO_1904959`

Added

regulation of cytochrome-c oxidase activity SubClassOf regulation of oxidoreductase activity

regulation of cytotoxic T cell differentiation `http://purl.obolibrary.org/obo/GO_0045583`

Removed

regulation of cytotoxic T cell differentiation definition “Any process that modulates the frequency, rate or extent of cytotoxic T cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of cytotoxic T cell differentiation definition “Any process that modulates the frequency, rate or extent of cytotoxic T cell differentiation.”
- database_cross_reference “GOC:curators”

regulation of developmental growth `http://purl.obolibrary.org/obo/GO_0048638`

Removed

regulation of developmental growth definition “Any process that modulates the frequency, rate or extent of developmental growth.”
- database_cross_reference “GOC:go_curators”

Added

regulation of developmental growth definition “Any process that modulates the frequency, rate or extent of developmental growth.”
- database_cross_reference “GOC:curators”

regulation of developmental process `http://purl.obolibrary.org/obo/GO_0050793`

Removed

regulation of developmental process definition “Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).”
- database_cross_reference “GOC:go_curators”

Added

regulation of developmental process definition “Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).”
- database_cross_reference “GOC:curators”

regulation of dopamine metabolic process `http://purl.obolibrary.org/obo/GO_0042053`

Removed

regulation of dopamine metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine.”
- database_cross_reference “GOC:go_curators”

Added

regulation of dopamine metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine.”
- database_cross_reference “GOC:curators”

regulation of ecdysteroid biosynthetic process `http://purl.obolibrary.org/obo/GO_0007554`

Removed

regulation of ecdysteroid biosynthetic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids.”
- database_cross_reference “GOC:go_curators”

Added

regulation of ecdysteroid biosynthetic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids.”
- database_cross_reference “GOC:curators”

regulation of ecdysteroid secretion `http://purl.obolibrary.org/obo/GO_0007555`

Removed

regulation of ecdysteroid secretion definition “Any process that modulates the frequency, rate or extent of the regulated release of ecdysteroid from a cell.”
- database_cross_reference “GOC:go_curators”

Added

regulation of ecdysteroid secretion definition “Any process that modulates the frequency, rate or extent of the regulated release of ecdysteroid from a cell.”
- database_cross_reference “GOC:curators”

regulation of eclosion `http://purl.obolibrary.org/obo/GO_0007563`

Removed

regulation of eclosion definition “Any process that modulates the frequency, rate or extent of the emergence of an insect from a pupa-case or of a larva from an egg.”
- database_cross_reference “ISBN:0198600461”
- database_cross_reference “GOC:go_curators”

Added

regulation of eclosion definition “Any process that modulates the frequency, rate or extent of the emergence of an insect from a pupa-case or of a larva from an egg.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198600461”

regulation of ectodermal cell fate specification `http://purl.obolibrary.org/obo/GO_0042665`

Removed

regulation of ectodermal cell fate specification definition “Any process that mediates the specification of a cell into an ectoderm cell.”
- database_cross_reference “GOC:go_curators”

Added

regulation of ectodermal cell fate specification definition “Any process that mediates the specification of a cell into an ectoderm cell.”
- database_cross_reference “GOC:curators”

regulation of embryo sac central cell differentiation `http://purl.obolibrary.org/obo/GO_0045691`

Removed

regulation of embryo sac central cell differentiation definition “Any process that modulates the frequency, rate or extent of female gametophyte central cell differentiation.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_plant”

Added

regulation of embryo sac central cell differentiation definition “Any process that modulates the frequency, rate or extent of female gametophyte central cell differentiation.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_plant”

regulation of embryo sac egg cell differentiation `http://purl.obolibrary.org/obo/GO_0045694`

Removed

regulation of embryo sac egg cell differentiation definition “Any process that modulates the frequency, rate or extent of embryo sac egg cell differentiation.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_plant”

Added

regulation of embryo sac egg cell differentiation definition “Any process that modulates the frequency, rate or extent of embryo sac egg cell differentiation.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_plant”

regulation of embryonic development `http://purl.obolibrary.org/obo/GO_0045995`

Removed

regulation of embryonic development definition “Any process that modulates the frequency, rate or extent of embryonic development.”
- database_cross_reference “GOC:go_curators”

Added

regulation of embryonic development definition “Any process that modulates the frequency, rate or extent of embryonic development.”
- database_cross_reference “GOC:curators”

regulation of endocytosis `http://purl.obolibrary.org/obo/GO_0030100`

Removed

regulation of endocytosis definition “Any process that modulates the frequency, rate or extent of endocytosis.”
- database_cross_reference “GOC:go_curators”

Added

regulation of endocytosis definition “Any process that modulates the frequency, rate or extent of endocytosis.”
- database_cross_reference “GOC:curators”

regulation of endodermal cell fate specification `http://purl.obolibrary.org/obo/GO_0042663`

Removed

regulation of endodermal cell fate specification definition “Any process that mediates the specification of a cell into an endoderm cell.”
- database_cross_reference “GOC:go_curators”

Added

regulation of endodermal cell fate specification definition “Any process that mediates the specification of a cell into an endoderm cell.”
- database_cross_reference “GOC:curators”

regulation of endothelial cell differentiation `http://purl.obolibrary.org/obo/GO_0045601`

Removed

regulation of endothelial cell differentiation definition “Any process that modulates the frequency, rate or extent of endothelial cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of endothelial cell differentiation definition “Any process that modulates the frequency, rate or extent of endothelial cell differentiation.”
- database_cross_reference “GOC:curators”

regulation of eosinophil differentiation `http://purl.obolibrary.org/obo/GO_0045643`

Removed

regulation of eosinophil differentiation definition “Any process that modulates the frequency, rate or extent of eosinophil differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of eosinophil differentiation definition “Any process that modulates the frequency, rate or extent of eosinophil differentiation.”
- database_cross_reference “GOC:curators”

regulation of epidermal cell differentiation `http://purl.obolibrary.org/obo/GO_0045604`

Removed

regulation of epidermal cell differentiation definition “Any process that modulates the frequency, rate or extent of epidermal cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of epidermal cell differentiation definition “Any process that modulates the frequency, rate or extent of epidermal cell differentiation.”
- database_cross_reference “GOC:curators”

regulation of epidermal growth factor receptor signaling pathway `http://purl.obolibrary.org/obo/GO_0042058`

Removed

regulation of epidermal growth factor receptor signaling pathway definition “Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.”
- database_cross_reference “GOC:go_curators”

Added

regulation of epidermal growth factor receptor signaling pathway definition “Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.”
- database_cross_reference “GOC:curators”

regulation of epidermis development `http://purl.obolibrary.org/obo/GO_0045682`

Removed

regulation of epidermis development definition “Any process that modulates the frequency, rate or extent of epidermis development.”
- database_cross_reference “GOC:go_curators”

Added

regulation of epidermis development definition “Any process that modulates the frequency, rate or extent of epidermis development.”
- database_cross_reference “GOC:curators”

regulation of erythrocyte differentiation `http://purl.obolibrary.org/obo/GO_0045646`

Removed

regulation of erythrocyte differentiation definition “Any process that modulates the frequency, rate or extent of erythrocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of erythrocyte differentiation definition “Any process that modulates the frequency, rate or extent of erythrocyte differentiation.”
- database_cross_reference “GOC:curators”

regulation of exocytosis `http://purl.obolibrary.org/obo/GO_0017157`

Removed

regulation of exocytosis definition “Any process that modulates the frequency, rate or extent of exocytosis.”
- database_cross_reference “GOC:go_curators”

Added

regulation of exocytosis definition “Any process that modulates the frequency, rate or extent of exocytosis.”
- database_cross_reference “GOC:curators”

regulation of fat cell differentiation `http://purl.obolibrary.org/obo/GO_0045598`

Removed

regulation of fat cell differentiation definition “Any process that modulates the frequency, rate or extent of adipocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of fat cell differentiation definition “Any process that modulates the frequency, rate or extent of adipocyte differentiation.”
- database_cross_reference “GOC:curators”

regulation of fatty acid biosynthetic process `http://purl.obolibrary.org/obo/GO_0042304`

Removed

regulation of fatty acid biosynthetic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:go_curators”

Added

regulation of fatty acid biosynthetic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:curators”

regulation of fatty acid metabolic process `http://purl.obolibrary.org/obo/GO_0019217`

Removed

regulation of fatty acid metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.”
- database_cross_reference “GOC:go_curators”

Added

regulation of fatty acid metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.”
- database_cross_reference “GOC:curators”

regulation of female receptivity `http://purl.obolibrary.org/obo/GO_0045924`

Removed

regulation of female receptivity definition “Any process that modulates the frequency, rate or extent of the willingness or readiness of a female to receive male advances.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

regulation of female receptivity definition “Any process that modulates the frequency, rate or extent of the willingness or readiness of a female to receive male advances.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

regulation of female receptivity, post-mating `http://purl.obolibrary.org/obo/GO_0046008`

Removed

regulation of female receptivity, post-mating definition “Any process that modulates the receptiveness of a female to male advances subsequent to mating.”
- database_cross_reference “GOC:go_curators”

Added

regulation of female receptivity, post-mating definition “Any process that modulates the receptiveness of a female to male advances subsequent to mating.”
- database_cross_reference “GOC:curators”

regulation of fibroblast growth factor receptor signaling pathway `http://purl.obolibrary.org/obo/GO_0040036`

Removed

regulation of fibroblast growth factor receptor signaling pathway definition “Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.”
- database_cross_reference “GOC:go_curators”

Added

regulation of fibroblast growth factor receptor signaling pathway definition “Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.”
- database_cross_reference “GOC:curators”

regulation of flower development `http://purl.obolibrary.org/obo/GO_0009909`

Removed

regulation of flower development definition “Any process that modulates the frequency, rate or extent of flower development.”
- database_cross_reference “GOC:go_curators”

Added

regulation of flower development definition “Any process that modulates the frequency, rate or extent of flower development.”
- database_cross_reference “GOC:curators”

regulation of forward locomotion `http://purl.obolibrary.org/obo/GO_0043059`

Removed

regulation of forward locomotion definition “Any process that modulates the speed, mechanical force, or rhythm of the anterior movement of an organism.”
- database_cross_reference “GOC:go_curators”

Added

regulation of forward locomotion definition “Any process that modulates the speed, mechanical force, or rhythm of the anterior movement of an organism.”
- database_cross_reference “GOC:curators”

regulation of fusion of sperm to egg plasma membrane `http://purl.obolibrary.org/obo/GO_0043012`

Removed

regulation of fusion of sperm to egg plasma membrane SubClassOf regulation of plasma membrane organization

Added

regulation of fusion of sperm to egg plasma membrane SubClassOf regulation of cellular process

regulation of gamma-delta T cell differentiation `http://purl.obolibrary.org/obo/GO_0045586`

Removed

regulation of gamma-delta T cell differentiation definition “Any process that modulates the frequency, rate or extent of gamma-delta T cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of gamma-delta T cell differentiation definition “Any process that modulates the frequency, rate or extent of gamma-delta T cell differentiation.”
- database_cross_reference “GOC:curators”

regulation of gibberellic acid mediated signaling pathway `http://purl.obolibrary.org/obo/GO_0009937`

Removed

regulation of gibberellic acid mediated signaling pathway definition “Any process that modulates the frequency, rate or extent of gibberellic acid mediated signaling.”
- database_cross_reference “GOC:go_curators”

Added

regulation of gibberellic acid mediated signaling pathway definition “Any process that modulates the frequency, rate or extent of gibberellic acid mediated signaling.”
- database_cross_reference “GOC:curators”

regulation of glial cell differentiation `http://purl.obolibrary.org/obo/GO_0045685`

Removed

regulation of glial cell differentiation definition “Any process that modulates the frequency, rate or extent of glia cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of glial cell differentiation definition “Any process that modulates the frequency, rate or extent of glia cell differentiation.”
- database_cross_reference “GOC:curators”

regulation of gluconeogenesis `http://purl.obolibrary.org/obo/GO_0006111`

Removed

regulation of gluconeogenesis definition “Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.”
- database_cross_reference “GOC:go_curators”

Added

regulation of gluconeogenesis definition “Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.”
- database_cross_reference “GOC:curators”

regulation of glucose catabolic process to lactate via pyruvate `http://purl.obolibrary.org/obo/GO_1904023`

Removed

Added

regulation of glycogen biosynthetic process `http://purl.obolibrary.org/obo/GO_0005979`

Removed

regulation of glycogen biosynthetic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.”
- database_cross_reference “GOC:go_curators”

Added

regulation of glycogen biosynthetic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.”
- database_cross_reference “GOC:curators”

regulation of glycogen catabolic process `http://purl.obolibrary.org/obo/GO_0005981`

Removed

regulation of glycogen catabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.”
- database_cross_reference “GOC:go_curators”

Added

regulation of glycogen catabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.”
- database_cross_reference “GOC:curators”

regulation of glycolytic process `http://purl.obolibrary.org/obo/GO_0006110`

Removed

regulation of glycolytic process definition “Any process that modulates the frequency, rate or extent of glycolysis.”
- database_cross_reference “GOC:go_curators”

Added

regulation of glycolytic process definition “Any process that modulates the frequency, rate or extent of glycolysis.”
- database_cross_reference “GOC:curators”

regulation of hair cycle `http://purl.obolibrary.org/obo/GO_0042634`

Removed

regulation of hair cycle definition “Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair.”
- database_cross_reference “PMID:12230507”
- database_cross_reference “GOC:go_curators”

Added

regulation of hair cycle definition “Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair.”
- database_cross_reference “PMID:12230507”
- database_cross_reference “GOC:curators”

regulation of heart contraction `http://purl.obolibrary.org/obo/GO_0008016`

Removed

regulation of heart contraction definition “Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

regulation of heart contraction definition “Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

regulation of hemocyte differentiation `http://purl.obolibrary.org/obo/GO_0045610`

Removed

regulation of hemocyte differentiation definition “Any process that modulates the frequency, rate or extent of hemocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of hemocyte differentiation definition “Any process that modulates the frequency, rate or extent of hemocyte differentiation.”
- database_cross_reference “GOC:curators”

regulation of imaginal disc growth `http://purl.obolibrary.org/obo/GO_0045570`

Removed

regulation of imaginal disc growth definition “Any process that modulates the frequency, rate or extent of the growth of the imaginal disc.”
- database_cross_reference “GOC:go_curators”

Added

regulation of imaginal disc growth definition “Any process that modulates the frequency, rate or extent of the growth of the imaginal disc.”
- database_cross_reference “GOC:curators”

regulation of indoleacetic acid biosynthetic process via tryptophan `http://purl.obolibrary.org/obo/GO_1901996`

Removed

regulation of indoleacetic acid biosynthetic process via tryptophan SubClassOf obsolete regulation of L-tryptophan metabolic process

Added

regulation of inner ear auditory receptor cell differentiation `http://purl.obolibrary.org/obo/GO_0045607`

Removed

regulation of inner ear auditory receptor cell differentiation definition “Any process that modulates the frequency, rate or extent of auditory hair cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of inner ear auditory receptor cell differentiation definition “Any process that modulates the frequency, rate or extent of auditory hair cell differentiation.”
- database_cross_reference “GOC:curators”

regulation of inner ear auditory receptor cell fate specification `http://purl.obolibrary.org/obo/GO_0042669`

Removed

regulation of inner ear auditory receptor cell fate specification definition “Any process that mediates the specification of a cell into an auditory hair cell.”
- database_cross_reference “GOC:go_curators”

Added

regulation of inner ear auditory receptor cell fate specification definition “Any process that mediates the specification of a cell into an auditory hair cell.”
- database_cross_reference “GOC:curators”

regulation of integrin biosynthetic process `http://purl.obolibrary.org/obo/GO_0045113`

Removed

regulation of integrin biosynthetic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins.”
- database_cross_reference “GOC:go_curators”

Added

regulation of integrin biosynthetic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins.”
- database_cross_reference “GOC:curators”

regulation of intracellular pH `http://purl.obolibrary.org/obo/GO_0051453`

Removed

regulation of intracellular pH definition “Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:ai”
regulation of intracellular pH SubClassOf obsolete regulation of cellular pH

Added

regulation of intracellular pH definition “Any process that modulates the internal pH of a cell, corresponding to a change in hydrogen ion concentration.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:ai”
regulation of intracellular pH has_exact_synonym “proton homeostasis”
regulation of intracellular pH has_exact_synonym “regulation of cellular pH”
regulation of intracellular pH has_exact_synonym “cellular hydrogen ion homeostasis”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:tb”
regulation of intracellular pH SubClassOf regulation of pH
regulation of intracellular pH SubClassOf intracellular monoatomic cation homeostasis

regulation of isoprenoid metabolic process `http://purl.obolibrary.org/obo/GO_0019747`

Removed

regulation of isoprenoid metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids.”
- database_cross_reference “GOC:go_curators”

Added

regulation of isoprenoid metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids.”
- database_cross_reference “GOC:curators”

regulation of juvenile hormone biosynthetic process `http://purl.obolibrary.org/obo/GO_0007557`

Removed

regulation of juvenile hormone biosynthetic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone.”
- database_cross_reference “GOC:go_curators”

Added

regulation of juvenile hormone biosynthetic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone.”
- database_cross_reference “GOC:curators”

regulation of juvenile hormone catabolic process `http://purl.obolibrary.org/obo/GO_0045952`

Removed

regulation of juvenile hormone catabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone.”
- database_cross_reference “GOC:go_curators”

Added

regulation of juvenile hormone catabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone.”
- database_cross_reference “GOC:curators”

regulation of juvenile hormone secretion `http://purl.obolibrary.org/obo/GO_0007558`

Removed

regulation of juvenile hormone secretion definition “Any process that modulates the frequency, rate or extent of juvenile hormone secretion.”
- database_cross_reference “GOC:go_curators”

Added

regulation of juvenile hormone secretion definition “Any process that modulates the frequency, rate or extent of juvenile hormone secretion.”
- database_cross_reference “GOC:curators”

regulation of keratinocyte differentiation `http://purl.obolibrary.org/obo/GO_0045616`

Removed

regulation of keratinocyte differentiation definition “Any process that modulates the frequency, rate or extent of keratinocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of keratinocyte differentiation definition “Any process that modulates the frequency, rate or extent of keratinocyte differentiation.”
- database_cross_reference “GOC:curators”

regulation of larval salivary gland boundary specification `http://purl.obolibrary.org/obo/GO_0045708`

Removed

regulation of larval salivary gland boundary specification definition “Any process that modulates the frequency, rate or extent of salivary gland determination in a larval organism.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

regulation of larval salivary gland boundary specification definition “Any process that modulates the frequency, rate or extent of salivary gland determination in a larval organism.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

regulation of lipid metabolic process `http://purl.obolibrary.org/obo/GO_0019216`

Removed

regulation of lipid metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.”
- database_cross_reference “GOC:go_curators”

Added

regulation of lipid metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.”
- database_cross_reference “GOC:curators”

regulation of lymphocyte differentiation `http://purl.obolibrary.org/obo/GO_0045619`

Removed

regulation of lymphocyte differentiation definition “Any process that modulates the frequency, rate or extent of lymphocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of lymphocyte differentiation definition “Any process that modulates the frequency, rate or extent of lymphocyte differentiation.”
- database_cross_reference “GOC:curators”

regulation of lysine biosynthetic process via aminoadipic acid `http://purl.obolibrary.org/obo/GO_1902986`

Removed

Added

regulation of lysine biosynthetic process via aminoadipic acid EquivalentTo biological regulation and (regulates some L-lysine biosynthetic process)
regulation of lysine biosynthetic process via aminoadipic acid SubClassOf regulates some L-lysine biosynthetic process

regulation of macromolecule biosynthetic process `http://purl.obolibrary.org/obo/GO_0010556`

Added

regulation of macromolecule biosynthetic process in_subset gocheck_do_not_annotate
regulation of macromolecule biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31483”^^anyURI

regulation of macrophage differentiation `http://purl.obolibrary.org/obo/GO_0045649`

Removed

regulation of macrophage differentiation definition “Any process that modulates the frequency, rate or extent of macrophage differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of macrophage differentiation definition “Any process that modulates the frequency, rate or extent of macrophage differentiation.”
- database_cross_reference “GOC:curators”

regulation of mating-type specific transcription, DNA-templated `http://purl.obolibrary.org/obo/GO_0007532`

Removed

regulation of mating-type specific transcription, DNA-templated definition “Any mating-type specific process that modulates the frequency, rate or extent of cellular DNA-templated transcription.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:txnOH”

Added

regulation of mating-type specific transcription, DNA-templated definition “Any mating-type specific process that modulates the frequency, rate or extent of cellular DNA-templated transcription.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:txnOH”

regulation of mechanoreceptor differentiation `http://purl.obolibrary.org/obo/GO_0045631`

Removed

regulation of mechanoreceptor differentiation definition “Any process that modulates the frequency, rate or extent of mechanoreceptor differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of mechanoreceptor differentiation definition “Any process that modulates the frequency, rate or extent of mechanoreceptor differentiation.”
- database_cross_reference “GOC:curators”

regulation of megakaryocyte differentiation `http://purl.obolibrary.org/obo/GO_0045652`

Removed

regulation of megakaryocyte differentiation definition “Any process that modulates the frequency, rate or extent of megakaryocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of megakaryocyte differentiation definition “Any process that modulates the frequency, rate or extent of megakaryocyte differentiation.”
- database_cross_reference “GOC:curators”

regulation of melanocyte differentiation `http://purl.obolibrary.org/obo/GO_0045634`

Removed

regulation of melanocyte differentiation definition “Any process that modulates the frequency, rate or extent of melanocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of melanocyte differentiation definition “Any process that modulates the frequency, rate or extent of melanocyte differentiation.”
- database_cross_reference “GOC:curators”

regulation of mesodermal cell fate specification `http://purl.obolibrary.org/obo/GO_0042661`

Removed

regulation of mesodermal cell fate specification definition “Any process that modulates the frequency, rate or extent of mesoderm cell fate specification.”
- database_cross_reference “GOC:go_curators”

Added

regulation of mesodermal cell fate specification definition “Any process that modulates the frequency, rate or extent of mesoderm cell fate specification.”
- database_cross_reference “GOC:curators”

regulation of metabolic process `http://purl.obolibrary.org/obo/GO_0019222`

Removed

regulation of metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.”
- database_cross_reference “GOC:go_curators”

Added

regulation of metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.”
- database_cross_reference “GOC:curators”

regulation of mitotic cell cycle `http://purl.obolibrary.org/obo/GO_0007346`

Removed

regulation of mitotic cell cycle definition “Any process that modulates the rate or extent of progress through the mitotic cell cycle.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

regulation of mitotic cell cycle definition “Any process that modulates the rate or extent of progress through the mitotic cell cycle.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

regulation of mitotic cell cycle, embryonic `http://purl.obolibrary.org/obo/GO_0009794`

Removed

regulation of mitotic cell cycle, embryonic definition “Any process that modulates the frequency, rate or extent of replication and segregation of genetic material in the embryo.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

regulation of mitotic cell cycle, embryonic definition “Any process that modulates the frequency, rate or extent of replication and segregation of genetic material in the embryo.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

regulation of mitotic nuclear division `http://purl.obolibrary.org/obo/GO_0007088`

Removed

regulation of mitotic nuclear division definition “Any process that modulates the frequency, rate or extent of mitosis.”
- database_cross_reference “GOC:go_curators”

Added

regulation of mitotic nuclear division definition “Any process that modulates the frequency, rate or extent of mitosis.”
- database_cross_reference “GOC:curators”

regulation of mitotic recombination `http://purl.obolibrary.org/obo/GO_0000019`

Removed

regulation of mitotic recombination definition “Any process that modulates the frequency, rate or extent of DNA recombination during mitosis.”
- database_cross_reference “GOC:go_curators”

Added

regulation of mitotic recombination definition “Any process that modulates the frequency, rate or extent of DNA recombination during mitosis.”
- database_cross_reference “GOC:curators”

regulation of monocyte differentiation `http://purl.obolibrary.org/obo/GO_0045655`

Removed

regulation of monocyte differentiation definition “Any process that modulates the frequency, rate or extent of monocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of monocyte differentiation definition “Any process that modulates the frequency, rate or extent of monocyte differentiation.”
- database_cross_reference “GOC:curators”

regulation of muscle adaptation `http://purl.obolibrary.org/obo/GO_0043502`

Removed

regulation of muscle adaptation definition “Any process that modulates the frequency, rate or extent of muscle adaptation.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_muscle”

Added

regulation of muscle adaptation definition “Any process that modulates the frequency, rate or extent of muscle adaptation.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_muscle”

regulation of muscle contraction `http://purl.obolibrary.org/obo/GO_0006937`

Removed

regulation of muscle contraction definition “Any process that modulates the frequency, rate or extent of muscle contraction.”
- database_cross_reference “GOC:go_curators”

Added

regulation of muscle contraction definition “Any process that modulates the frequency, rate or extent of muscle contraction.”
- database_cross_reference “GOC:curators”

regulation of muscle organ development `http://purl.obolibrary.org/obo/GO_0048634`

Removed

regulation of muscle organ development definition “Any process that modulates the frequency, rate or extent of muscle development.”
- database_cross_reference “GOC:go_curators”

Added

regulation of muscle organ development definition “Any process that modulates the frequency, rate or extent of muscle development.”
- database_cross_reference “GOC:curators”

regulation of myeloid cell differentiation `http://purl.obolibrary.org/obo/GO_0045637`

Removed

regulation of myeloid cell differentiation definition “Any process that modulates the frequency, rate or extent of myeloid cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of myeloid cell differentiation definition “Any process that modulates the frequency, rate or extent of myeloid cell differentiation.”
- database_cross_reference “GOC:curators”

regulation of myoblast differentiation `http://purl.obolibrary.org/obo/GO_0045661`

Removed

regulation of myoblast differentiation definition “Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “CL:0000056”
- database_cross_reference “GOC:mtg_muscle”

Added

regulation of myoblast differentiation definition “Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.”
- database_cross_reference “GOC:curators”
- database_cross_reference “CL:0000056”
- database_cross_reference “GOC:mtg_muscle”

regulation of neuron apoptotic process `http://purl.obolibrary.org/obo/GO_0043523`

Removed

regulation of neuron apoptotic process definition “Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_apoptosis”

Added

regulation of neuron apoptotic process definition “Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_apoptosis”

regulation of neuron differentiation `http://purl.obolibrary.org/obo/GO_0045664`

Removed

regulation of neuron differentiation definition “Any process that modulates the frequency, rate or extent of neuron differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of neuron differentiation definition “Any process that modulates the frequency, rate or extent of neuron differentiation.”
- database_cross_reference “GOC:curators”

regulation of neutrophil differentiation `http://purl.obolibrary.org/obo/GO_0045658`

Removed

regulation of neutrophil differentiation definition “Any process that modulates the frequency, rate or extent of neutrophil differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of neutrophil differentiation definition “Any process that modulates the frequency, rate or extent of neutrophil differentiation.”
- database_cross_reference “GOC:curators”

regulation of nitric oxide biosynthetic process `http://purl.obolibrary.org/obo/GO_0045428`

Removed

regulation of nitric oxide biosynthetic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.”
- database_cross_reference “GOC:go_curators”

Added

regulation of nitric oxide biosynthetic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.”
- database_cross_reference “GOC:curators”

regulation of nitric oxide-cGMP mediated signal transduction `http://purl.obolibrary.org/obo/GO_0141149`

Removed

regulation of nitric oxide-cGMP mediated signal transduction SubClassOf obsolete regulation of nitric oxide mediated signal transduction

Added

regulation of nitric oxide-cGMP mediated signal transduction SubClassOf regulation of intracellular signal transduction

regulation of nitrogen utilization `http://purl.obolibrary.org/obo/GO_0006808`

Removed

regulation of nitrogen utilization definition “Any process that modulates the frequency, rate or extent of nitrogen utilization.”
- database_cross_reference “GOC:go_curators”

Added

regulation of nitrogen utilization definition “Any process that modulates the frequency, rate or extent of nitrogen utilization.”
- database_cross_reference “GOC:curators”

regulation of nucleobase-containing compound metabolic process `http://purl.obolibrary.org/obo/GO_0019219`

Removed

regulation of nucleobase-containing compound metabolic process definition “Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.”
- database_cross_reference “GOC:go_curators”

Added

regulation of nucleobase-containing compound metabolic process in_subset gocheck_do_not_annotate
regulation of nucleobase-containing compound metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31498”^^anyURI
regulation of nucleobase-containing compound metabolic process definition “Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.”
- database_cross_reference “GOC:curators”

regulation of nucleoside metabolic process `http://purl.obolibrary.org/obo/GO_0009118`

Removed

regulation of nucleoside metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleosides.”
- database_cross_reference “GOC:go_curators”

Added

regulation of nucleoside metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleosides.”
- database_cross_reference “GOC:curators”

regulation of nucleotide metabolic process `http://purl.obolibrary.org/obo/GO_0006140`

Removed

regulation of nucleotide metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.”
- database_cross_reference “GOC:go_curators”

Added

regulation of nucleotide metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.”
- database_cross_reference “GOC:curators”

regulation of ornithine catabolic process `http://purl.obolibrary.org/obo/GO_1903266`

Removed

regulation of ornithine catabolic process SubClassOf obsolete regulation of ornithine metabolic process

Added

regulation of oskar mRNA translation `http://purl.obolibrary.org/obo/GO_0046011`

Removed

regulation of oskar mRNA translation definition “Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:12538512”

Added

regulation of oskar mRNA translation definition “Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:12538512”

regulation of ossification `http://purl.obolibrary.org/obo/GO_0030278`

Removed

regulation of ossification definition “Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.”
- database_cross_reference “GOC:go_curators”

Added

regulation of ossification definition “Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.”
- database_cross_reference “GOC:curators”

regulation of osteoblast differentiation `http://purl.obolibrary.org/obo/GO_0045667`

Removed

regulation of osteoblast differentiation definition “Any process that modulates the frequency, rate or extent of osteoblast differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of osteoblast differentiation definition “Any process that modulates the frequency, rate or extent of osteoblast differentiation.”
- database_cross_reference “GOC:curators”

regulation of osteoclast differentiation `http://purl.obolibrary.org/obo/GO_0045670`

Removed

regulation of osteoclast differentiation definition “Any process that modulates the frequency, rate or extent of osteoclast differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of osteoclast differentiation definition “Any process that modulates the frequency, rate or extent of osteoclast differentiation.”
- database_cross_reference “GOC:curators”

regulation of pH `http://purl.obolibrary.org/obo/GO_0006885`

Removed

regulation of pH definition “Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

regulation of pH definition “Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

regulation of phosphatidylinositol biosynthetic process `http://purl.obolibrary.org/obo/GO_0010511`

Removed

regulation of phosphatidylinositol biosynthetic process SubClassOf regulation of phospholipid biosynthetic process

Added

regulation of phosphatidylinositol dephosphorylation `http://purl.obolibrary.org/obo/GO_0060304`

Removed

regulation of phosphatidylinositol dephosphorylation SubClassOf regulation of phospholipid metabolic process

Added

regulation of phosphatidylinositol dephosphorylation SubClassOf regulation of lipid metabolic process

regulation of phosphorus utilization `http://purl.obolibrary.org/obo/GO_0006795`

Removed

regulation of phosphorus utilization definition “Any process that modulates the frequency, rate or extent of phosphorus utilization.”
- database_cross_reference “GOC:go_curators”

Added

regulation of phosphorus utilization definition “Any process that modulates the frequency, rate or extent of phosphorus utilization.”
- database_cross_reference “GOC:curators”

regulation of photoreceptor cell differentiation `http://purl.obolibrary.org/obo/GO_0046532`

Removed

regulation of photoreceptor cell differentiation definition “Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.”
- database_cross_reference “GOC:go_curators”

Added

regulation of photoreceptor cell differentiation definition “Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.”
- database_cross_reference “GOC:curators”

regulation of pinocytosis `http://purl.obolibrary.org/obo/GO_0048548`

Removed

regulation of pinocytosis definition “Any process that modulates the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally ‘cell drinking’. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes.”
- database_cross_reference “GOC:go_curators”

Added

regulation of pinocytosis definition “Any process that modulates the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally ‘cell drinking’. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes.”
- database_cross_reference “GOC:curators”

regulation of plasmatocyte differentiation `http://purl.obolibrary.org/obo/GO_0045613`

Removed

regulation of plasmatocyte differentiation definition “Any process that modulates the frequency, rate or extent of plasmatocyte differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of plasmatocyte differentiation definition “Any process that modulates the frequency, rate or extent of plasmatocyte differentiation.”
- database_cross_reference “GOC:curators”

regulation of preblastoderm mitotic cell cycle `http://purl.obolibrary.org/obo/GO_0007347`

Removed

regulation of preblastoderm mitotic cell cycle definition “A cell cycle process that modulates the rate or extent of the progression through the preblastoderm mitotic cell cycle.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

regulation of preblastoderm mitotic cell cycle definition “A cell cycle process that modulates the rate or extent of the progression through the preblastoderm mitotic cell cycle.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

regulation of primary metabolic process `http://purl.obolibrary.org/obo/GO_0080090`

Added

regulation of primary metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31498”^^anyURI
regulation of primary metabolic process in_subset gocheck_do_not_annotate

regulation of protein binding `http://purl.obolibrary.org/obo/GO_0043393`

Removed

regulation of protein binding definition “Any process that modulates the frequency, rate or extent of protein binding.”
- database_cross_reference “GOC:go_curators”

Added

regulation of protein binding definition “Any process that modulates the frequency, rate or extent of protein binding.”
- database_cross_reference “GOC:curators”

regulation of protein catabolic process `http://purl.obolibrary.org/obo/GO_0042176`

Removed

regulation of protein catabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:go_curators”

Added

regulation of protein catabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:curators”

regulation of protein kinase activity `http://purl.obolibrary.org/obo/GO_0045859`

Removed

regulation of protein kinase activity definition “Any process that modulates the frequency, rate or extent of protein kinase activity.”
- database_cross_reference “GOC:go_curators”

Added

regulation of protein kinase activity definition “Any process that modulates the frequency, rate or extent of protein kinase activity.”
- database_cross_reference “GOC:curators”

regulation of protein modification process `http://purl.obolibrary.org/obo/GO_0031399`

Removed

regulation of protein modification process in_subset goslim_yeast

regulation of purine nucleobase metabolic process `http://purl.obolibrary.org/obo/GO_0006141`

Removed

regulation of purine nucleobase metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving purines.”
- database_cross_reference “GOC:go_curators”
regulation of purine nucleobase metabolic process has_exact_synonym “regulation of purine base metabolic process”
- database_cross_reference “GOC:go_curators”

Added

regulation of purine nucleobase metabolic process has_exact_synonym “regulation of purine base metabolic process”
- database_cross_reference “GOC:curators”
regulation of purine nucleobase metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving purines.”
- database_cross_reference “GOC:curators”

regulation of purine nucleotide biosynthetic process `http://purl.obolibrary.org/obo/GO_1900371`

Removed

regulation of purine nucleotide biosynthetic process definition “Any process that modulates the frequency, rate or extent of purine nucleotide biosynthetic processes.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:TermGenie”

Added

regulation of purine nucleotide biosynthetic process definition “Any process that modulates the frequency, rate or extent of purine nucleotide biosynthetic processes.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:TermGenie”

regulation of receptor-mediated endocytosis `http://purl.obolibrary.org/obo/GO_0048259`

Removed

regulation of receptor-mediated endocytosis definition “Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

regulation of receptor-mediated endocytosis definition “Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

regulation of retinal cone cell fate specification `http://purl.obolibrary.org/obo/GO_0042673`

Removed

regulation of retinal cone cell fate specification definition “Any process that mediates the specification of a cell into a retinal cone cell.”
- database_cross_reference “GOC:go_curators”

Added

regulation of retinal cone cell fate specification definition “Any process that mediates the specification of a cell into a retinal cone cell.”
- database_cross_reference “GOC:curators”

regulation of salivary gland boundary specification `http://purl.obolibrary.org/obo/GO_0045704`

Removed

regulation of salivary gland boundary specification definition “Any process that modulates the frequency, rate or extent of salivary gland determination.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

regulation of salivary gland boundary specification definition “Any process that modulates the frequency, rate or extent of salivary gland determination.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

regulation of sevenless signaling pathway `http://purl.obolibrary.org/obo/GO_0045501`

Removed

regulation of sevenless signaling pathway definition “Any process that modulates the frequency, rate or extent of the sevenless signaling pathway.”
- database_cross_reference “GOC:go_curators”

Added

regulation of sevenless signaling pathway definition “Any process that modulates the frequency, rate or extent of the sevenless signaling pathway.”
- database_cross_reference “GOC:curators”

regulation of single stranded viral RNA replication via double stranded DNA intermediate `http://purl.obolibrary.org/obo/GO_0045091`

Removed

regulation of single stranded viral RNA replication via double stranded DNA intermediate definition “Any process that modulates the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate.”
- database_cross_reference “GOC:go_curators”

Added

regulation of single stranded viral RNA replication via double stranded DNA intermediate definition “Any process that modulates the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate.”
- database_cross_reference “GOC:curators”

regulation of sister chromatid cohesion `http://purl.obolibrary.org/obo/GO_0007063`

Removed

regulation of sister chromatid cohesion definition “Any process that modulates the frequency, rate or extent of sister chromatid cohesion.”
- database_cross_reference “GOC:go_curators”

Added

regulation of sister chromatid cohesion definition “Any process that modulates the frequency, rate or extent of sister chromatid cohesion.”
- database_cross_reference “GOC:curators”

regulation of skeletal muscle tissue development `http://purl.obolibrary.org/obo/GO_0048641`

Removed

regulation of skeletal muscle tissue development definition “Any process that modulates the frequency, rate or extent of skeletal muscle tissue development.”
- database_cross_reference “GOC:go_curators”

Added

regulation of skeletal muscle tissue development definition “Any process that modulates the frequency, rate or extent of skeletal muscle tissue development.”
- database_cross_reference “GOC:curators”

regulation of small GTPase mediated signal transduction `http://purl.obolibrary.org/obo/GO_0051056`

Removed

regulation of small GTPase mediated signal transduction definition “Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.”
- database_cross_reference “GOC:go_curators”

Added

regulation of small GTPase mediated signal transduction definition “Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.”
- database_cross_reference “GOC:curators”

regulation of small molecule metabolic process `http://purl.obolibrary.org/obo/GO_0062012`

Added

regulation of small molecule metabolic process in_subset gocheck_do_not_annotate
regulation of small molecule metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31485”^^anyURI

regulation of smooth muscle contraction `http://purl.obolibrary.org/obo/GO_0006940`

Removed

regulation of smooth muscle contraction definition “Any process that modulates the frequency, rate or extent of smooth muscle contraction.”
- database_cross_reference “GOC:go_curators”

Added

regulation of smooth muscle contraction definition “Any process that modulates the frequency, rate or extent of smooth muscle contraction.”
- database_cross_reference “GOC:curators”

regulation of smoothened signaling pathway `http://purl.obolibrary.org/obo/GO_0008589`

Removed

regulation of smoothened signaling pathway definition “Any process that modulates the frequency, rate or extent of smoothened signaling.”
- database_cross_reference “GOC:go_curators”

Added

regulation of smoothened signaling pathway definition “Any process that modulates the frequency, rate or extent of smoothened signaling.”
- database_cross_reference “GOC:curators”

regulation of spermatid nuclear differentiation `http://purl.obolibrary.org/obo/GO_0045700`

Removed

regulation of spermatid nuclear differentiation definition “Any process that modulates the frequency, rate or extent of spermatid nuclear differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of spermatid nuclear differentiation definition “Any process that modulates the frequency, rate or extent of spermatid nuclear differentiation.”
- database_cross_reference “GOC:curators”

regulation of steroid metabolic process `http://purl.obolibrary.org/obo/GO_0019218`

Removed

regulation of steroid metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids.”
- database_cross_reference “GOC:go_curators”

Added

regulation of steroid metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids.”
- database_cross_reference “GOC:curators”

regulation of striated muscle contraction `http://purl.obolibrary.org/obo/GO_0006942`

Removed

regulation of striated muscle contraction definition “Any process that modulates the frequency, rate or extent of striated muscle contraction.”
- database_cross_reference “GOC:go_curators”

Added

regulation of striated muscle contraction definition “Any process that modulates the frequency, rate or extent of striated muscle contraction.”
- database_cross_reference “GOC:curators”

regulation of striated muscle tissue development `http://purl.obolibrary.org/obo/GO_0016202`

Removed

regulation of striated muscle tissue development definition “Any process that modulates the frequency, rate or extent of striated muscle development.”
- database_cross_reference “GOC:go_curators”

Added

regulation of striated muscle tissue development definition “Any process that modulates the frequency, rate or extent of striated muscle development.”
- database_cross_reference “GOC:curators”

regulation of sulfur metabolic process `http://purl.obolibrary.org/obo/GO_0042762`

Removed

regulation of sulfur metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur.”
- database_cross_reference “GOC:go_curators”

Added

regulation of sulfur metabolic process definition “Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur.”
- database_cross_reference “GOC:curators”

regulation of sulfur utilization `http://purl.obolibrary.org/obo/GO_0006792`

Removed

regulation of sulfur utilization definition “Any process that modulates the frequency, rate or extent of sulfur utilization.”
- database_cross_reference “GOC:go_curators”

Added

regulation of sulfur utilization definition “Any process that modulates the frequency, rate or extent of sulfur utilization.”
- database_cross_reference “GOC:curators”

regulation of synaptic assembly at neuromuscular junction `http://purl.obolibrary.org/obo/GO_0008582`

Removed

regulation of synaptic assembly at neuromuscular junction definition “Any process that modulates the frequency, rate or extent of synaptic assembly at neuromuscular junctions.”
- database_cross_reference “GOC:go_curators”

Added

regulation of synaptic assembly at neuromuscular junction definition “Any process that modulates the frequency, rate or extent of synaptic assembly at neuromuscular junctions.”
- database_cross_reference “GOC:curators”

regulation of syncytial blastoderm mitotic cell cycle `http://purl.obolibrary.org/obo/GO_0007348`

Removed

regulation of syncytial blastoderm mitotic cell cycle definition “A cell cycle process that modulates the rate or extent of the progression through the syncytial blastoderm mitotic cell cycle.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

regulation of syncytial blastoderm mitotic cell cycle definition “A cell cycle process that modulates the rate or extent of the progression through the syncytial blastoderm mitotic cell cycle.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

regulation of syncytium formation by plasma membrane fusion `http://purl.obolibrary.org/obo/GO_0060142`

Removed

regulation of syncytium formation by plasma membrane fusion SubClassOf regulation of developmental process

regulation of synergid differentiation `http://purl.obolibrary.org/obo/GO_0045697`

Removed

regulation of synergid differentiation definition “Any process that modulates the frequency, rate or extent of synergid cell differentiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of synergid differentiation definition “Any process that modulates the frequency, rate or extent of synergid cell differentiation.”
- database_cross_reference “GOC:curators”

regulation of tetrapyrrole biosynthetic process from glutamate `http://purl.obolibrary.org/obo/GO_1901410`

Removed

regulation of tetrapyrrole biosynthetic process from glutamate SubClassOf obsolete regulation of glutamate metabolic process

Added

regulation of transcription by RNA polymerase I `http://purl.obolibrary.org/obo/GO_0006356`

Removed

regulation of transcription by RNA polymerase I definition “Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase I.”
- database_cross_reference “GOC:go_curators”

Added

regulation of transcription by RNA polymerase I definition “Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase I.”
- database_cross_reference “GOC:curators”

regulation of transcription by RNA polymerase II `http://purl.obolibrary.org/obo/GO_0006357`

Removed

regulation of transcription by RNA polymerase II definition “Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:txnOH”

Added

regulation of transcription by RNA polymerase II definition “Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:txnOH”

regulation of transcription by RNA polymerase III `http://purl.obolibrary.org/obo/GO_0006359`

Removed

regulation of transcription by RNA polymerase III definition “Any process that modulates the frequency, rate or extent of transcription mediated by RNA ploymerase III.”
- database_cross_reference “GOC:go_curators”

Added

regulation of transcription by RNA polymerase III definition “Any process that modulates the frequency, rate or extent of transcription mediated by RNA ploymerase III.”
- database_cross_reference “GOC:curators”

regulation of transcription by galactose `http://purl.obolibrary.org/obo/GO_0000409`

Removed

regulation of transcription by galactose definition “Any process involving galactose that modulates the frequency, rate or extent or transcription.”
- database_cross_reference “GOC:go_curators”

Added

regulation of transcription by galactose definition “Any process involving galactose that modulates the frequency, rate or extent or transcription.”
- database_cross_reference “GOC:curators”

regulation of transcription by glucose `http://purl.obolibrary.org/obo/GO_0046015`

Removed

regulation of transcription by glucose definition “Any process involving glucose that modulates the frequency, rate or extent or transcription.”
- database_cross_reference “GOC:go_curators”

Added

regulation of transcription by glucose definition “Any process involving glucose that modulates the frequency, rate or extent or transcription.”
- database_cross_reference “GOC:curators”

regulation of translation, ncRNA-mediated `http://purl.obolibrary.org/obo/GO_0045974`

Removed

regulation of translation, ncRNA-mediated definition “Any process, mediated by small non-coding RNAs, that modulates the frequency, rate or extent that mRNAs are effectively translated into protein.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

regulation of translation, ncRNA-mediated definition “Any process, mediated by small non-coding RNAs, that modulates the frequency, rate or extent that mRNAs are effectively translated into protein.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

regulation of translational elongation `http://purl.obolibrary.org/obo/GO_0006448`

Removed

regulation of translational elongation definition “Any process that modulates the frequency, rate, extent or accuracy of translational elongation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of translational elongation definition “Any process that modulates the frequency, rate, extent or accuracy of translational elongation.”
- database_cross_reference “GOC:curators”

regulation of translational initiation `http://purl.obolibrary.org/obo/GO_0006446`

Removed

regulation of translational initiation definition “Any process that modulates the frequency, rate or extent of translational initiation.”
- database_cross_reference “GOC:go_curators”

Added

regulation of translational initiation definition “Any process that modulates the frequency, rate or extent of translational initiation.”
- database_cross_reference “GOC:curators”

regulation of translational termination `http://purl.obolibrary.org/obo/GO_0006449`

Removed

regulation of translational termination definition “Any process that modulates the frequency, rate or extent of translational termination.”
- database_cross_reference “GOC:go_curators”

Added

regulation of translational termination definition “Any process that modulates the frequency, rate or extent of translational termination.”
- database_cross_reference “GOC:curators”

regulation of uterine smooth muscle contraction `http://purl.obolibrary.org/obo/GO_0070472`

Removed

regulation of uterine smooth muscle contraction definition “Any process that modulates the frequency, rate or extent of uterine smooth muscle contraction.”
- database_cross_reference “GOC:go_curators”

Added

regulation of uterine smooth muscle contraction definition “Any process that modulates the frequency, rate or extent of uterine smooth muscle contraction.”
- database_cross_reference “GOC:curators”

regulation of viral process `http://purl.obolibrary.org/obo/GO_0050792`

Removed

regulation of viral process definition “Any process that modulates the rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”

Added

regulation of viral process definition “Any process that modulates the rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”

release of sequestered calcium ion into cytosol `http://purl.obolibrary.org/obo/GO_0051209`

Added

release of sequestered calcium ion into cytosol SubClassOf intercellular transport

rescue of stalled cytosolic ribosome `http://purl.obolibrary.org/obo/GO_0072344`

Added

rescue of stalled cytosolic ribosome database_cross_reference “Reactome:R-HSA-9948299”
- label “Ribosome-associated quality control”

respiratory chain complex III `http://purl.obolibrary.org/obo/GO_0045275`

Added

respiratory chain complex III SubClassOf oxidoreductase complex

respiratory chain complex IV `http://purl.obolibrary.org/obo/GO_0045277`

Added

respiratory chain complex IV SubClassOf oxidoreductase complex

response to absence of light `http://purl.obolibrary.org/obo/GO_0009646`

Removed

response to absence of light definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli.”
- database_cross_reference “GOC:go_curators”

Added

response to absence of light definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli.”
- database_cross_reference “GOC:curators”

response to acid chemical `http://purl.obolibrary.org/obo/GO_0001101`

Removed

response to acid chemical definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:rn”

Added

response to acid chemical definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:rn”

response to acidic pH `http://purl.obolibrary.org/obo/GO_0010447`

Removed

response to acidic pH definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”
- database_cross_reference “Wikipedia:PH”

Added

response to acidic pH definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”
- database_cross_reference “Wikipedia:PH”

response to alkaline pH `http://purl.obolibrary.org/obo/GO_0010446`

Removed

response to alkaline pH definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:tb”
- database_cross_reference “Wikipedia:PH”

Added

response to alkaline pH definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:tb”
- database_cross_reference “Wikipedia:PH”

response to antibiotic `http://purl.obolibrary.org/obo/GO_0046677`

Added

response to antibiotic database_cross_reference “Reactome:R-HSA-9638771”
- label “Action of antimicrobials”
response to antibiotic database_cross_reference “Reactome:R-HSA-9913143”
- label “Antimicrobial resistance”

response to ethanol `http://purl.obolibrary.org/obo/GO_0045471`

Removed

response to ethanol definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.”
- database_cross_reference “GOC:go_curators”

Added

response to ethanol definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.”
- database_cross_reference “GOC:curators”

response to ether `http://purl.obolibrary.org/obo/GO_0045472`

Removed

response to ether definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus.”
- database_cross_reference “GOC:go_curators”

Added

response to ether definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus.”
- database_cross_reference “GOC:curators”

response to exogenous dsRNA `http://purl.obolibrary.org/obo/GO_0043330`

Removed

response to exogenous dsRNA definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.”
- database_cross_reference “GOC:go_curators”

Added

response to exogenous dsRNA definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.”
- database_cross_reference “GOC:curators”

response to external biotic stimulus `http://purl.obolibrary.org/obo/GO_0043207`

Removed

response to external biotic stimulus definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things.”
- database_cross_reference “GOC:go_curators”

Added

response to external biotic stimulus definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things.”
- database_cross_reference “GOC:curators”

response to high light intensity `http://purl.obolibrary.org/obo/GO_0009644`

Removed

response to high light intensity definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus.”
- database_cross_reference “GOC:go_curators”

Added

response to high light intensity definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus.”
- database_cross_reference “GOC:curators”

response to isolation stress `http://purl.obolibrary.org/obo/GO_0035900`

Removed

response to isolation stress SubClassOf response to stress

Added

response to isolation stress term tracker item “https://github.com/geneontology/go-ontology/issues/31407”^^anyURI
response to isolation stress SubClassOf multicellular organismal response to stress

response to light intensity `http://purl.obolibrary.org/obo/GO_0009642`

Removed

response to light intensity definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus.”
- database_cross_reference “GOC:go_curators”

Added

response to light intensity definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus.”
- database_cross_reference “GOC:curators”

response to light stimulus `http://purl.obolibrary.org/obo/GO_0009416`

Removed

response to light stimulus definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0582227089”

Added

response to light stimulus definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0582227089”

response to low light intensity stimulus `http://purl.obolibrary.org/obo/GO_0009645`

Removed

response to low light intensity stimulus definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_far_red”

Added

response to low light intensity stimulus definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_far_red”

response to misfolded protein `http://purl.obolibrary.org/obo/GO_0051788`

Removed

response to misfolded protein definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus.”
- database_cross_reference “GOC:go_curators”

Added

response to misfolded protein definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus.”
- database_cross_reference “GOC:curators”

response to nutrient `http://purl.obolibrary.org/obo/GO_0007584`

Removed

response to nutrient definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.”
- database_cross_reference “GOC:go_curators”

Added

response to nutrient definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.”
- database_cross_reference “GOC:curators”

response to photoperiod, blue light `http://purl.obolibrary.org/obo/GO_0009906`

Removed

response to photoperiod, blue light definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a blue light photoperiod stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_far_red”

Added

response to photoperiod, blue light definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a blue light photoperiod stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_far_red”

response to photoperiod, red light `http://purl.obolibrary.org/obo/GO_0009907`

Removed

response to photoperiod, red light definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light photoperiod stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_far_red”

Added

response to photoperiod, red light definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light photoperiod stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_far_red”

response to psychosocial stress `http://purl.obolibrary.org/obo/GO_1990911`

Removed

response to psychosocial stress SubClassOf response to stress

Added

response to psychosocial stress term tracker item “https://github.com/geneontology/go-ontology/issues/31407”^^anyURI
response to psychosocial stress SubClassOf multicellular organismal response to stress

response to starvation `http://purl.obolibrary.org/obo/GO_0042594`

Removed

response to starvation definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.”
- database_cross_reference “GOC:go_curators”

Added

response to starvation definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.”
- database_cross_reference “GOC:curators”

response to steroid hormone `http://purl.obolibrary.org/obo/GO_0048545`

Removed

response to steroid hormone definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.”
- database_cross_reference “GOC:go_curators”

Added

response to steroid hormone definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.”
- database_cross_reference “GOC:curators”

response to wounding `http://purl.obolibrary.org/obo/GO_0009611`

Removed

response to wounding definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.”
- database_cross_reference “GOC:go_curators”

Added

response to wounding definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.”
- database_cross_reference “GOC:curators”

retinal cone cell differentiation `http://purl.obolibrary.org/obo/GO_0042670`

Removed

retinal cone cell differentiation definition “The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell.”
- database_cross_reference “GOC:go_curators”

Added

retinal cone cell differentiation definition “The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell.”
- database_cross_reference “GOC:curators”

retinal cone cell fate determination `http://purl.obolibrary.org/obo/GO_0042671`

Removed

retinal cone cell fate determination definition “The process in which a cell becomes capable of differentiating autonomously into a retinal cone cell regardless of its environment; upon determination, the cell fate cannot be reversed.”
- database_cross_reference “GOC:go_curators”

Added

retinal cone cell fate determination definition “The process in which a cell becomes capable of differentiating autonomously into a retinal cone cell regardless of its environment; upon determination, the cell fate cannot be reversed.”
- database_cross_reference “GOC:curators”

retinal cone cell fate specification `http://purl.obolibrary.org/obo/GO_0042672`

Removed

retinal cone cell fate specification definition “The process in which a cell becomes capable of differentiating autonomously into a retinal cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.”
- database_cross_reference “GOC:go_curators”

Added

retinal cone cell fate specification definition “The process in which a cell becomes capable of differentiating autonomously into a retinal cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.”
- database_cross_reference “GOC:curators”

retinal dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0001758`

Added

retinal dehydrogenase (NAD+) activity narrowMatch 42080
retinal dehydrogenase (NAD+) activity database_cross_reference “RHEA:67332”
retinal dehydrogenase (NAD+) activity narrowMatch 67332
retinal dehydrogenase (NAD+) activity database_cross_reference “RHEA:42084”
retinal dehydrogenase (NAD+) activity database_cross_reference “RHEA:47132”
retinal dehydrogenase (NAD+) activity narrowMatch 42084
retinal dehydrogenase (NAD+) activity narrowMatch 47132
retinal dehydrogenase (NAD+) activity database_cross_reference “RHEA:42080”

retinol O-fatty-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0050252`

Added

retinol O-fatty-acyltransferase activity database_cross_reference “RHEA:38175”
retinol O-fatty-acyltransferase activity narrowMatch 38175
retinol O-fatty-acyltransferase activity narrowMatch 55284
retinol O-fatty-acyltransferase activity database_cross_reference “RHEA:55284”

retrograde transport, endosome to Golgi `http://purl.obolibrary.org/obo/GO_0042147`

Added

retrograde transport, endosome to Golgi SubClassOf intercellular transport

rhamnose catabolic process `http://purl.obolibrary.org/obo/GO_0019301`

Added

rhamnose catabolic process narrowMatch PWY-6714
rhamnose catabolic process narrowMatch RHAMCAT-PWY
rhamnose catabolic process database_cross_reference “MetaCyc:PWY-6713”
rhamnose catabolic process database_cross_reference “MetaCyc:PWY-6714”
rhamnose catabolic process narrowMatch PWY-6713
rhamnose catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI

rhythmic excitation `http://purl.obolibrary.org/obo/GO_0043179`

Removed

rhythmic excitation definition “Any process involved in the generation of rhythmic, synchronous excitatory synaptic inputs in a neural circuit.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0195088433”

Added

rhythmic excitation definition “Any process involved in the generation of rhythmic, synchronous excitatory synaptic inputs in a neural circuit.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0195088433”

rhythmic inhibition `http://purl.obolibrary.org/obo/GO_0043180`

Removed

rhythmic inhibition definition “Any process involved in the generation of rhythmic, synchronous inhibitory synaptic inputs in a neural circuit.”
- database_cross_reference “GOC:go_curators”

Added

rhythmic inhibition definition “Any process involved in the generation of rhythmic, synchronous inhibitory synaptic inputs in a neural circuit.”
- database_cross_reference “GOC:curators”

ribitol beta-1,4-xylosyltransferase activity `http://purl.obolibrary.org/obo/GO_0120053`

Added

ribitol beta-1,4-xylosyltransferase activity database_cross_reference “Reactome:R-HSA-9940805”
- label “RXYLT1 transfers initial Xyl to matriglycan chain”

riboflavin biosynthetic process `http://purl.obolibrary.org/obo/GO_0009231`

Removed

riboflavin biosynthetic process database_cross_reference “MetaCyc:RIBOSYN2-PWY”

Added

riboflavin biosynthetic process broadMatch PWY66-366
riboflavin biosynthetic process broadMatch PWY-616
riboflavin biosynthetic process broadMatch RIBOSYN2-PWY
riboflavin biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
riboflavin biosynthetic process broadMatch PWY-6168

ribonucleoprotein complex binding `http://purl.obolibrary.org/obo/GO_0043021`

Removed

ribonucleoprotein complex binding definition “Binding to a complex of RNA and protein.”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:vk”

Added

ribonucleoprotein complex binding definition “Binding to a complex of RNA and protein.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:vk”

ribonucleoprotein granule `http://purl.obolibrary.org/obo/GO_0035770`

Removed

ribonucleoprotein granule definition “A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:16520386”
- database_cross_reference “PMID:21436445”
- database_cross_reference “GOC:sp”
- database_cross_reference “PMID:20368989”

Added

ribonucleoprotein granule definition “A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:16520386”
- database_cross_reference “PMID:21436445”
- database_cross_reference “GOC:sp”
- database_cross_reference “PMID:20368989”

ribonucleoside diphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009188`

Removed

ribonucleoside diphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

ribonucleoside diphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

ribonucleoside diphosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009191`

Removed

ribonucleoside diphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

ribonucleoside diphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

ribonucleoside diphosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009185`

Removed

ribonucleoside diphosphate metabolic process definition “The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

ribonucleoside diphosphate metabolic process definition “The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

ribonucleoside monophosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009156`

Removed

ribonucleoside monophosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

ribonucleoside monophosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

ribonucleoside monophosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009158`

Removed

ribonucleoside monophosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

ribonucleoside monophosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

ribonucleoside triphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009201`

Removed

ribonucleoside triphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

ribonucleoside triphosphate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

ribonucleoside triphosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009203`

Removed

ribonucleoside triphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

ribonucleoside triphosphate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

ribonucleoside triphosphate phosphatase activity `http://purl.obolibrary.org/obo/GO_0017111`

Added

ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor `http://purl.obolibrary.org/obo/GO_0004748`

Added

ribonucleotide biosynthetic process `http://purl.obolibrary.org/obo/GO_0009260`

Removed

ribonucleotide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

ribonucleotide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

ribonucleotide catabolic process `http://purl.obolibrary.org/obo/GO_0009261`

Removed

ribonucleotide catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

ribonucleotide catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

ribonucleotide metabolic process `http://purl.obolibrary.org/obo/GO_0009259`

Removed

ribonucleotide metabolic process definition “The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

ribonucleotide metabolic process definition “The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3’ or 5’-hydroxyl group of the sugar.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

ribose phosphate diphosphokinase activity `http://purl.obolibrary.org/obo/GO_0004749`

Removed

ribose phosphate diphosphokinase activity database_cross_reference “Reactome:R-HSA-73580”
- label “D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5’-monophosphate”
ribose phosphate diphosphokinase activity comment “Note that this term has a MetaCyc pathway reference as the pathway only has a single step.”
ribose phosphate diphosphokinase activity relatedMatch PWY0-662
ribose phosphate diphosphokinase activity database_cross_reference “Reactome:R-HSA-111215”
- label “D-ribose 5-phosphate + 2’-deoxyadenosine 5’-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2’-deoxyadenosine 5’-monophosphate”

Added

ribose phosphate diphosphokinase activity database_cross_reference “Reactome:R-HSA-73580”
- label “PRPS dimers pyrophosphorylate R5P using ATP”
ribose phosphate diphosphokinase activity database_cross_reference “Reactome:R-HSA-111215”
- label “PRPS1 dimer pyrophosphorylates R5P using dATP”
ribose phosphate diphosphokinase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI

ribose-5-phosphate isomerase activity `http://purl.obolibrary.org/obo/GO_0004751`

Removed

ribose-5-phosphate isomerase activity database_cross_reference “Reactome:R-HSA-177784”
- label “ribose 5-phosphate <=> D-ribulose 5-phosphate”
ribose-5-phosphate isomerase activity database_cross_reference “Reactome:R-HSA-71306”
- label “D-ribulose 5-phosphate <=> ribose 5-phosphate”

Added

ribose-5-phosphate isomerase activity database_cross_reference “Reactome:R-HSA-177784”
- label “RPIA isomerizes ribose 5-phosphate to D-ribulose 5-phosphate”
ribose-5-phosphate isomerase activity database_cross_reference “Reactome:R-HSA-71306”
- label “RPIA isomerizes D-ribulose 5-phosphate to ribose 5-phosphate”

ribosomal large subunit binding `http://purl.obolibrary.org/obo/GO_0043023`

Removed

ribosomal large subunit binding definition “Binding to a large ribosomal subunit.”
- database_cross_reference “GOC:go_curators”

Added

ribosomal large subunit binding definition “Binding to a large ribosomal subunit.”
- database_cross_reference “GOC:curators”

ribosomal small subunit binding `http://purl.obolibrary.org/obo/GO_0043024`

Removed

ribosomal small subunit binding definition “Binding to a small ribosomal subunit.”
- database_cross_reference “GOC:go_curators”

Added

ribosomal small subunit binding definition “Binding to a small ribosomal subunit.”
- database_cross_reference “GOC:curators”

ribosome binding `http://purl.obolibrary.org/obo/GO_0043022`

Removed

ribosome binding definition “Binding to a ribosome.”
- database_cross_reference “GOC:go_curators”

Added

ribosome binding definition “Binding to a ribosome.”
- database_cross_reference “GOC:curators”

ribosylpyrimidine nucleosidase activity `http://purl.obolibrary.org/obo/GO_0050263`

Added

ribosylpyrimidine nucleosidase activity narrowMatch 27958
ribosylpyrimidine nucleosidase activity database_cross_reference “RHEA:27958”

ricinine nitrilase activity `http://purl.obolibrary.org/obo/GO_0047426`

Removed

ricinine nitrilase activity definition “Catalysis of the reaction: H2O + ricinine = NH3 + 3-carboxy-4-methoxy-N-methyl-2-pyridone.”
- database_cross_reference “EC:3.5.5.2”

Added

ricinine nitrilase activity definition “Catalysis of the reaction: ricinine + 2 H2O = 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4+.”
- database_cross_reference “RHEA:22704”

sabinene synthase activity `http://purl.obolibrary.org/obo/GO_0080015`

Added

sabinene synthase activity narrowMatch 32547
sabinene synthase activity narrowMatch 25508
sabinene synthase activity database_cross_reference “RHEA:32547”
sabinene synthase activity database_cross_reference “RHEA:25508”

salicylic acid biosynthetic process `http://purl.obolibrary.org/obo/GO_0009697`

Added

salicylic acid biosynthetic process narrowMatch PWY-6406
salicylic acid biosynthetic process narrowMatch PWY-8321
salicylic acid biosynthetic process database_cross_reference “MetaCyc:PWY-6406”
salicylic acid biosynthetic process narrowMatch PWY-981
salicylic acid biosynthetic process database_cross_reference “MetaCyc:PWY-8321”
salicylic acid biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI

saponin biosynthetic process `http://purl.obolibrary.org/obo/GO_0016135`

Removed

saponin biosynthetic process definition “The chemical reactions and pathways resulting in the formation of saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection.”
- database_cross_reference “GOC:go_curators”

Added

saponin biosynthetic process definition “The chemical reactions and pathways resulting in the formation of saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection.”
- database_cross_reference “GOC:curators”

saponin catabolic process `http://purl.obolibrary.org/obo/GO_0016136`

Removed

saponin catabolic process definition “The chemical reactions and pathways resulting in the breakdown of saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection.”
- database_cross_reference “GOC:go_curators”

Added

saponin catabolic process definition “The chemical reactions and pathways resulting in the breakdown of saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection.”
- database_cross_reference “GOC:curators”

secondary active transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015291`

Added

secondary active transmembrane transporter activity database_cross_reference “Reactome:R-HSA-561059”
- label “OAT2 and OAT4 mediate transport of sulphate conjugates”
secondary active transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9661799”
- label “SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)”
secondary active transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9661723”
- label “SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)”
secondary active transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9749583”
- label “SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes”
secondary active transmembrane transporter activity database_cross_reference “Reactome:R-HSA-879594”
- label “SLCO4C1 mediates the transport of digoxin”
secondary active transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9757010”
- label “SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol”
secondary active transmembrane transporter activity database_cross_reference “Reactome:R-HSA-549241”
- label “SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol”
secondary active transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9749607”
- label “SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells”
secondary active transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9661397”
- label “SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)”
secondary active transmembrane transporter activity database_cross_reference “Reactome:R-HSA-879562”
- label “SLCO2B1 has a narrow substrate specificity”
secondary active transmembrane transporter activity database_cross_reference “Reactome:R-HSA-879584”
- label “SLCO3A1 isoform 1 has a broad substrate specificity”
secondary active transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9661446”
- label “BMG, BDG translocates from ER lumen to cytosol”

secondary cell wall `http://purl.obolibrary.org/obo/GO_0009531`

Removed

secondary cell wall definition “A plant cell wall that is no longer able to expand and so does not permit growth. Secondary cell walls contain less pectin that primary cell walls. The secondary cell is mostly composed of cellulose and is strengthened with lignin.”
- database_cross_reference “GOC:jid”
- database_cross_reference “ISBN:0943088399”

Added

secondary cell wall definition “A plant cell wall that is no longer able to expand and so does not permit growth. Secondary cell walls contain less pectin that primary cell walls. The secondary cell is mostly composed of cellulose and is strengthened with lignin.”
- database_cross_reference “GOC:jid”
- database_cross_reference “ISBN:0943088399”
- database_cross_reference “PMID:39878232”

secondary metabolic process `http://purl.obolibrary.org/obo/GO_0019748`

Removed

secondary metabolic process definition “The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients.”
- database_cross_reference “GOC:go_curators”

Added

secondary metabolic process definition “The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients.”
- database_cross_reference “GOC:curators”

secondary-alcohol oxidase activity `http://purl.obolibrary.org/obo/GO_0033714`

Added

secondary-alcohol oxidase activity narrowMatch 68964
secondary-alcohol oxidase activity database_cross_reference “RHEA:68968”
secondary-alcohol oxidase activity narrowMatch 68968
secondary-alcohol oxidase activity database_cross_reference “RHEA:68964”

seed coat development `http://purl.obolibrary.org/obo/GO_0010214`

Removed

seed coat development definition “The process whose specific outcome is the progression of the seed coat over time, from its formation to the mature structure.”
- database_cross_reference “GOC:go_curators”

Added

seed coat development definition “The process whose specific outcome is the progression of the seed coat over time, from its formation to the mature structure.”
- database_cross_reference “GOC:curators”

seed germination on parent plant `http://purl.obolibrary.org/obo/GO_0048623`

Removed

seed germination on parent plant definition “The process in which a seed germinates before being shed from the parent plant.”
- database_cross_reference “GOC:go_curators”

Added

seed germination on parent plant definition “The process in which a seed germinates before being shed from the parent plant.”
- database_cross_reference “GOC:curators”

seed morphogenesis `http://purl.obolibrary.org/obo/GO_0048317`

Removed

seed morphogenesis definition “The process in which the anatomical structures of the seed are generated and organized.”
- database_cross_reference “GOC:go_curators”

Added

seed morphogenesis definition “The process in which the anatomical structures of the seed are generated and organized.”
- database_cross_reference “GOC:curators”

selenate reductase activity `http://purl.obolibrary.org/obo/GO_0033797`

Added

selenate reductase activity narrowMatch 80603
selenate reductase activity database_cross_reference “RHEA:51636”
selenate reductase activity narrowMatch 51636
selenate reductase activity database_cross_reference “RHEA:80603”

selenocysteine insertion sequence binding `http://purl.obolibrary.org/obo/GO_0035368`

Added

selenocysteine insertion sequence binding database_cross_reference “Reactome:R-HSA-2408529”
- label “Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome”

sensory organ development `http://purl.obolibrary.org/obo/GO_0007423`

Removed

sensory organ development definition “The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure.”
- database_cross_reference “GOC:go_curators”

Added

sensory organ development definition “The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure.”
- database_cross_reference “GOC:curators”

sensory organ precursor cell fate determination `http://purl.obolibrary.org/obo/GO_0016360`

Removed

sensory organ precursor cell fate determination definition “The process in which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed.”
- database_cross_reference “GOC:go_curators”

Added

sensory organ precursor cell fate determination definition “The process in which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed.”
- database_cross_reference “GOC:curators”

sepal development `http://purl.obolibrary.org/obo/GO_0048442`

Removed

sepal development definition “The process whose specific outcome is the progression of the sepal over time, from its formation to the mature structure.”
- database_cross_reference “GOC:go_curators”

Added

sepal development definition “The process whose specific outcome is the progression of the sepal over time, from its formation to the mature structure.”
- database_cross_reference “GOC:curators”

sepal morphogenesis `http://purl.obolibrary.org/obo/GO_0048447`

Removed

sepal morphogenesis definition “The process in which the anatomical structures of the sepal are generated and organized.”
- database_cross_reference “GOC:go_curators”

Added

sepal morphogenesis definition “The process in which the anatomical structures of the sepal are generated and organized.”
- database_cross_reference “GOC:curators”

sepiapterin deaminase activity `http://purl.obolibrary.org/obo/GO_0050279`

Removed

sepiapterin deaminase activity definition “Catalysis of the reaction: sepiapterin + H2O = xanthopterin-B2 + NH3.”
- database_cross_reference “EC:3.5.4.24”
- database_cross_reference “MetaCyc:SEPIAPTERIN-DEAMINASE-RXN”

Added

sepiapterin deaminase activity definition “Catalysis of the reaction: L-sepiapterin + H2O + H+ = (S)-xanthopterin-B2 + NH4+.”
- database_cross_reference “RHEA:14025”

serine O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0016412`

Added

serine O-acyltransferase activity database_cross_reference “RHEA:68300”
serine O-acyltransferase activity database_cross_reference “RHEA:59972”
serine O-acyltransferase activity narrowMatch 68288
serine O-acyltransferase activity database_cross_reference “RHEA:68284”
serine O-acyltransferase activity narrowMatch 68296
serine O-acyltransferase activity database_cross_reference “RHEA:68292”
serine O-acyltransferase activity database_cross_reference “RHEA:68276”
serine O-acyltransferase activity database_cross_reference “RHEA:59964”
serine O-acyltransferase activity narrowMatch 68276
serine O-acyltransferase activity database_cross_reference “RHEA:68288”
serine O-acyltransferase activity narrowMatch 68280
serine O-acyltransferase activity narrowMatch 59972
serine O-acyltransferase activity database_cross_reference “RHEA:68296”
serine O-acyltransferase activity database_cross_reference “RHEA:68280”
serine O-acyltransferase activity narrowMatch 68284
serine O-acyltransferase activity narrowMatch 68292
serine O-acyltransferase activity narrowMatch 68300
serine O-acyltransferase activity narrowMatch 59964

serine family amino acid biosynthetic process `http://purl.obolibrary.org/obo/GO_0009070`

Removed

serine family amino acid biosynthetic process database_cross_reference “MetaCyc:PWY-6292”
serine family amino acid biosynthetic process narrowMatch SULFATE-CYS-PWY
serine family amino acid biosynthetic process narrowMatch SER-GLYSYN-PWY
serine family amino acid biosynthetic process narrowMatch PWY-6292
serine family amino acid biosynthetic process database_cross_reference “MetaCyc:SULFATE-CYS-PWY”
serine family amino acid biosynthetic process database_cross_reference “MetaCyc:SER-GLYSYN-PWY”

Added

serine family amino acid biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31525”^^anyURI

serine-sulfate ammonia-lyase activity `http://purl.obolibrary.org/obo/GO_0050283`

Removed

serine-sulfate ammonia-lyase activity definition “Catalysis of the reaction: L-serine O-sulfate + H2O = pyruvate + NH3 + sulfate.”
- database_cross_reference “EC:4.3.1.10”
- database_cross_reference “MetaCyc:SERINE-SULFATE-AMMONIA-LYASE-RXN”

Added

serine-sulfate ammonia-lyase activity definition “Catalysis of the reaction: -serine O-sulfate + H2O = sulfate + pyruvate + NH4+ + H+.”
- database_cross_reference “RHEA:15605”

serine-type endopeptidase activity `http://purl.obolibrary.org/obo/GO_0004252`

Removed

serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-2022411”
- label “Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)”
serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-140696”
- label “factor V -> factor Va + factor V activation peptide”

Added

serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9921689”
- label “NS3 cleaves GrpEL1”
serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9926963”
- label “Hbp cis-autocleaves”
serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9947496”
- label “ACOT2 cleaves NS345”
serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-140696”
- label “factor V -> factor Va + factor V activation peptide (thrombin catalyst)”
serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9911236”
- label “ELANE cleaves NOTCH2NLA”
serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9927009”
- label “Hbp(53-1100) cleaves hemoglobin”
serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-2022411”
- label “Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))”
serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9921595”
- label “NS2B3 cleaves FAM134B”
serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9918813”
- label “NS2B3 cleaves NS4AB”
serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-3244626”
- label “DENV protease NS2B3 cleaves STING”
serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9918817”
- label “NS2B3 cleaves polyprotein”
serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9911383”
- label “LepB cleaves prepro-STa”
serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9932162”
- label “Removal of CDH1 signal peptide”
serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9918823”
- label “NS345:NS2B cleaves NS345”
serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9918787”
- label “NS2B3 cleaves C-prM-E-NS1-NS2A”
serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9912368”
- label “LepB cleaves pre-EltA”
serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9918871”
- label “Signalase cleaves prepro-NS4B”
serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9926936”
- label “EspC(54-1018) cleaves hemoglobin”
serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9918795”
- label “Signalase cleaves prM-E-NS1-NS2A”
serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9918772”
- label “Dengue polyprotein cis-auto-cleaves”
serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9919050”
- label “Furin cleaves prM:E”
serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9912371”
- label “LepB cleaves pre-EltB”
serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9918780”
- label “Unknown peptidase cleaves NS1-NS2A”
serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9913329”
- label “Autoproteolysis of DAG1 to alpha and beta chains”
serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9816275”
- label “CDH1 is proteolytically cleaved in Golgi”
serine-type endopeptidase activity database_cross_reference “Reactome:R-HSA-9918876”
- label “NS2B3 cleaves prepro-C at the C-prM junction”

serine-type peptidase activity `http://purl.obolibrary.org/obo/GO_0008236`

Removed

serine-type peptidase activity database_cross_reference “Reactome:R-HSA-2022383”
- label “Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)”

Added

serine-type peptidase activity database_cross_reference “Reactome:R-HSA-2022383”
- label “Chymase hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))”

serotonin biosynthetic process `http://purl.obolibrary.org/obo/GO_0042427`

Added

serotonin biosynthetic process database_cross_reference “MetaCyc:PWY-8475”
serotonin biosynthetic process narrowMatch PWY-6030
serotonin biosynthetic process database_cross_reference “MetaCyc:PWY-6030”
serotonin biosynthetic process narrowMatch PWY-8475
serotonin biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31658”^^anyURI

serotonin biosynthetic process from L-tryptophan `http://purl.obolibrary.org/obo/GO_0006587`

Removed

Added

serotonin biosynthetic process from L-tryptophan term tracker item “https://github.com/geneontology/go-ontology/issues/31658”^^anyURI
serotonin biosynthetic process from L-tryptophan term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI

sesquiterpenoid biosynthetic process `http://purl.obolibrary.org/obo/GO_0016106`

Removed

sesquiterpenoid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of sesquiterpenoid compounds, terpenoids with three isoprene units.”
- database_cross_reference “GOC:go_curators”

Added

sesquiterpenoid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of sesquiterpenoid compounds, terpenoids with three isoprene units.”
- database_cross_reference “GOC:curators”

sesquiterpenoid catabolic process `http://purl.obolibrary.org/obo/GO_0016107`

Removed

sesquiterpenoid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of sesquiterpenoid compounds, terpenoids with three isoprene units.”
- database_cross_reference “GOC:go_curators”

Added

sesquiterpenoid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of sesquiterpenoid compounds, terpenoids with three isoprene units.”
- database_cross_reference “GOC:curators”

shikimate catabolic process `http://purl.obolibrary.org/obo/GO_0019633`

Removed

shikimate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of shikimate, (3R,4S,5R)–3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid.”
- database_cross_reference “GOC:go_curators”

Added

shikimate catabolic process database_cross_reference “MetaCyc:PWY-6419”
shikimate catabolic process narrowMatch PWY-6419
shikimate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of shikimate, (3R,4S,5R)–3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid.”
- database_cross_reference “GOC:curators”
shikimate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
shikimate catabolic process narrowMatch SHIKIMATEDEG-PWY

shoot system development `http://purl.obolibrary.org/obo/GO_0048367`

Removed

shoot system development definition “The process whose specific outcome is the progression of the shoot system over time, from its formation to the mature structure.”
- database_cross_reference “GOC:go_curators”

Added

shoot system development definition “The process whose specific outcome is the progression of the shoot system over time, from its formation to the mature structure.”
- database_cross_reference “GOC:curators”

short-chain fatty acid-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0031955`

Added

short-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:66988”
short-chain fatty acid-CoA ligase activity narrowMatch 46168
short-chain fatty acid-CoA ligase activity narrowMatch 46176
short-chain fatty acid-CoA ligase activity narrowMatch 66996
short-chain fatty acid-CoA ligase activity narrowMatch 46184
short-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:46172”
short-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:46184”
short-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:46176”
short-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:66992”
short-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:46168”
short-chain fatty acid-CoA ligase activity narrowMatch 66988
short-chain fatty acid-CoA ligase activity narrowMatch 66992
short-chain fatty acid-CoA ligase activity narrowMatch 46172
short-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:66996”

short-chain fatty acyl-CoA dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0016937`

Added

short-chain fatty acyl-CoA hydrolase activity `http://purl.obolibrary.org/obo/GO_0141126`

Removed

short-chain fatty acyl-CoA hydrolase activity relatedMatch 3.1.2.18

Added

short-chain fatty acyl-CoA hydrolase activity narrowMatch 40111
short-chain fatty acyl-CoA hydrolase activity narrowMatch 55084
short-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:45156”
short-chain fatty acyl-CoA hydrolase activity narrowMatch 66980
short-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:40111”
short-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:65208”
short-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:65204”
short-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:31251”
short-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:55052”
short-chain fatty acyl-CoA hydrolase activity narrowMatch 65204
short-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:55096”
short-chain fatty acyl-CoA hydrolase activity narrowMatch 31251
short-chain fatty acyl-CoA hydrolase activity narrowMatch 40103
short-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:40799”
short-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:55064”
short-chain fatty acyl-CoA hydrolase activity narrowMatch 45156
short-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:66980”
short-chain fatty acyl-CoA hydrolase activity narrowMatch 40799
short-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:66984”
short-chain fatty acyl-CoA hydrolase activity narrowMatch 65208
short-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:55084”
short-chain fatty acyl-CoA hydrolase activity database_cross_reference “EC:3.1.2.18”
short-chain fatty acyl-CoA hydrolase activity narrowMatch 55052
short-chain fatty acyl-CoA hydrolase activity database_cross_reference “RHEA:40103”
short-chain fatty acyl-CoA hydrolase activity narrowMatch 55096
short-chain fatty acyl-CoA hydrolase activity narrowMatch 55064
short-chain fatty acyl-CoA hydrolase activity narrowMatch 3.1.2.18
short-chain fatty acyl-CoA hydrolase activity narrowMatch 66984

short-chain fatty acyl-CoA oxidase activity `http://purl.obolibrary.org/obo/GO_0120522`

Added

short-chain fatty acyl-CoA oxidase activity narrowMatch 66200
short-chain fatty acyl-CoA oxidase activity database_cross_reference “RHEA:41964”
short-chain fatty acyl-CoA oxidase activity database_cross_reference “RHEA:66200”
short-chain fatty acyl-CoA oxidase activity narrowMatch 41964

side of membrane `http://purl.obolibrary.org/obo/GO_0098552`

Removed

side of membrane definition “A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface.”
- database_cross_reference “GOC:dos”

Added

side of membrane definition “A cellular component consisting of one leaflet of a membrane bilayer and any protein embedded or anchored in it or attached to its surface.”
- database_cross_reference “GOC:dos”

siderophore-iron transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015343`

Added

siderophore-iron transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9911605”
- label “FyuA transports Ybt:Fe/Cu from extracellular space to the periplasm”
siderophore-iron transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9931043”
- label “FecA:TonB:ExbB:ExbD imports Fe3+-citrates to periplasm”
siderophore-iron transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9930902”
- label “IutA imports FeAer to the periplasm”
siderophore-iron transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9930911”
- label “FhuBCD imports FeAer to the cytosol”
siderophore-iron transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9928256”
- label “YbtPQ transports Ybt:Fe/Cu to the cytosol”

signal transduction `http://purl.obolibrary.org/obo/GO_0007165`

Removed

signal transduction definition “The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:mtg_signaling_feb11”

Added

signal transduction definition “The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:mtg_signaling_feb11”

signal transduction in response to DNA damage `http://purl.obolibrary.org/obo/GO_0042770`

Removed

signal transduction in response to DNA damage definition “A cascade of processes induced by the detection of DNA damage within a cell.”
- database_cross_reference “GOC:go_curators”

Added

signal transduction in response to DNA damage definition “A cascade of processes induced by the detection of DNA damage within a cell.”
- database_cross_reference “GOC:curators”

signaling receptor complex `http://purl.obolibrary.org/obo/GO_0043235`

Removed

signaling receptor complex definition “Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.”
- database_cross_reference “GOC:go_curators”
signaling receptor complex label “receptor complex”

Added

signaling receptor complex term tracker item “https://github.com/geneontology/go-ontology/issues/31605”^^anyURI
signaling receptor complex definition “Any protein complex that binds a signaling molecule such as a hormone, neurotransmitter, molecular pattern recognition receptor (PAMPs and DAMPS), or an intracellular messenger to initiate a change in cell function.”
- database_cross_reference “GOC:curators”
signaling receptor complex has_broad_synonym “receptor complex”
signaling receptor complex label “signaling receptor complex”

single-stranded DNA endonuclease activity `http://purl.obolibrary.org/obo/GO_0000014`

Removed

single-stranded DNA endonuclease activity label “single-stranded DNA endodeoxyribonuclease activity”

Added

single-stranded DNA endonuclease activity has_exact_synonym “single-stranded DNA endodeoxyribonuclease activity”
single-stranded DNA endonuclease activity term tracker item “https://github.com/geneontology/go-ontology/issues/31721”^^anyURI
single-stranded DNA endonuclease activity label “single-stranded DNA endonuclease activity”

sirohydrochlorin ferrochelatase activity `http://purl.obolibrary.org/obo/GO_0051266`

Removed

sirohydrochlorin ferrochelatase activity SubClassOf protoporphyrin ferrochelatase activity

Added

sirohydrochlorin ferrochelatase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31620”^^anyURI
sirohydrochlorin ferrochelatase activity SubClassOf lyase activity

slime layer polysaccharide biosynthetic process `http://purl.obolibrary.org/obo/GO_0045228`

Removed

slime layer polysaccharide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of polysaccharides in the slime layer, a diffused layer of polysaccharide exterior to the bacterial cell wall.”
- database_cross_reference “GOC:go_curators”

Added

slime layer polysaccharide biosynthetic process definition “The chemical reactions and pathways resulting in the formation of polysaccharides in the slime layer, a diffused layer of polysaccharide exterior to the bacterial cell wall.”
- database_cross_reference “GOC:curators”

small RNA 2’-O-ribose methyltransferase activity `http://purl.obolibrary.org/obo/GO_0090486`

Removed

small RNA 2’-O-ribose methyltransferase activity label “small RNA 2’-O-methyltransferase activity”

Added

small RNA 2’-O-ribose methyltransferase activity has_exact_synonym “small RNA 2’-O-methyltransferase activity”
small RNA 2’-O-ribose methyltransferase activity label “small RNA 2’-O-ribose methyltransferase activity”

small molecule biosynthetic process `http://purl.obolibrary.org/obo/GO_0044283`

Added

small molecule biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31485”^^anyURI
small molecule biosynthetic process in_subset gocheck_do_not_annotate

small molecule catabolic process `http://purl.obolibrary.org/obo/GO_0044282`

Added

small molecule catabolic process in_subset gocheck_do_not_annotate
small molecule catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31485”^^anyURI

small molecule metabolic process `http://purl.obolibrary.org/obo/GO_0044281`

Added

small molecule metabolic process in_subset gocheck_do_not_annotate
small molecule metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31485”^^anyURI

sn-glycerol 3-phosphatase activity `http://purl.obolibrary.org/obo/GO_0043136`

Removed

sn-glycerol 3-phosphatase activity database_cross_reference “Reactome:R-HSA-8955794”
- label “PGP:Mg2+ dimer hydrolyses 3PG to glycerol”

Added

sn-glycerol 3-phosphatase activity database_cross_reference “Reactome:R-HSA-8955794”
- label “PGP:Mg2+ dimer hydrolyses G3P to glycerol”

sno(s)RNA 3’-end cleavage `http://purl.obolibrary.org/obo/GO_0043145`

Removed

sno(s)RNA 3’-end cleavage definition “The endonucleolytic cleavage of snoRNA 3’ ends, which is required for mature snoRNAs to be functional.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:12773397”

Added

sno(s)RNA 3’-end cleavage definition “The endonucleolytic cleavage of snoRNA 3’ ends, which is required for mature snoRNAs to be functional.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:12773397”

sno(s)RNA processing `http://purl.obolibrary.org/obo/GO_0043144`

Removed

sno(s)RNA processing definition “Any process involved in the conversion of a primary snoRNA family RNA transcript into a mature snoRNA (eukaryota) or sRNA (archaea).”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:krc”
- database_cross_reference “PMID:12773397”

Added

sno(s)RNA processing definition “Any process involved in the conversion of a primary snoRNA family RNA transcript into a mature snoRNA (eukaryota) or sRNA (archaea).”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:krc”
- database_cross_reference “PMID:12773397”

sodium ion transmembrane transport `http://purl.obolibrary.org/obo/GO_0035725`

Added

sodium ion transmembrane transport database_cross_reference “Reactome:R-HSA-425986”
- label “Sodium/Proton exchangers”

sodium-dependent organic anion transport `http://purl.obolibrary.org/obo/GO_0043251`

Removed

sodium-dependent organic anion transport definition “The directed, sodium-dependent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:go_curators”

Added

sodium-dependent organic anion transport definition “The directed, sodium-dependent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:curators”

sodium-independent organic anion transport `http://purl.obolibrary.org/obo/GO_0043252`

Removed

sodium-independent organic anion transport database_cross_reference “Reactome:R-HSA-879518”
- label “Transport of organic anions”
sodium-independent organic anion transport definition “The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:go_curators”

Added

sodium-independent organic anion transport database_cross_reference “Reactome:R-HSA-879518”
- label “Organic anion transport by SLCO transporters”
sodium-independent organic anion transport definition “The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:curators”

sodium:ammonium:chloride symporter activity `http://purl.obolibrary.org/obo/GO_7770002`

Removed

sodium:ammonium:chloride symporter activity definition “Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + NH4+(out) + Cl-(out) = Na+(in) + NH4+(in) + Cl-(in).”
- database_cross_reference “PMID:12657561”

Added

sodium:ammonium:chloride symporter activity database_cross_reference “RHEA:85511”
sodium:ammonium:chloride symporter activity exactMatch 85511
sodium:ammonium:chloride symporter activity definition “Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + NH4+(out) + Cl-(out) = Na+(in) + NH4+(in) + Cl-(in).”
- database_cross_reference “PMID:12657561”
- database_cross_reference “RHEA:85511”

soluble molecule recognition `http://purl.obolibrary.org/obo/GO_0009995`

Removed

soluble molecule recognition definition “The recognition of soluble molecules in the environment.”
- database_cross_reference “GOC:go_curators”

Added

soluble molecule recognition definition “The recognition of soluble molecules in the environment.”
- database_cross_reference “GOC:curators”

specification of symmetry `http://purl.obolibrary.org/obo/GO_0009799`

Removed

specification of symmetry definition “The establishment of an organism’s body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created.”
- database_cross_reference “GOC:go_curators”

Added

specification of symmetry definition “The establishment of an organism’s body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created.”
- database_cross_reference “GOC:curators”

sperm glycocalyx `http://purl.obolibrary.org/obo/GO_0120238`

Added

sperm glycocalyx term tracker item “https://github.com/geneontology/go-ontology/issues/31720”^^anyURI

spermatid development `http://purl.obolibrary.org/obo/GO_0007286`

Removed

spermatid development definition “The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:go_curators”

Added

spermatid development definition “The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:curators”

spermidine biosynthetic process `http://purl.obolibrary.org/obo/GO_0008295`

Removed

spermidine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

spermidine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

spermidine catabolic process `http://purl.obolibrary.org/obo/GO_0046203`

Added

spermidine catabolic process broadMatch PWY-6440
spermidine catabolic process broadMatch PWY-6117
spermidine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31766”^^anyURI
spermidine catabolic process broadMatch PWY-6441

spermine catabolic process `http://purl.obolibrary.org/obo/GO_0046208`

Added

spermine catabolic process broadMatch PWY-6440
spermine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31766”^^anyURI
spermine catabolic process broadMatch PWY-6441
spermine catabolic process broadMatch PWY-6117

sphingolipid C4-monooxygenase activity `http://purl.obolibrary.org/obo/GO_0102772`

Added

sphingolipid C4-monooxygenase activity database_cross_reference “Reactome:R-HSA-428260”
- label “DEGS2 oxygenates dihydroceramide”
sphingolipid C4-monooxygenase activity narrowMatch 81475
sphingolipid C4-monooxygenase activity database_cross_reference “RHEA:55476”
sphingolipid C4-monooxygenase activity narrowMatch 46364
sphingolipid C4-monooxygenase activity narrowMatch 55476
sphingolipid C4-monooxygenase activity database_cross_reference “RHEA:46364”
sphingolipid C4-monooxygenase activity database_cross_reference “RHEA:81475”

sphingolipid intramembrane carrier activity `http://purl.obolibrary.org/obo/GO_0046624`

Removed

sphingolipid intramembrane carrier activity label “sphingolipid transporter activity”
sphingolipid intramembrane carrier activity SubClassOf lipid carrier activity

Added

sphingolipid intramembrane carrier activity has_broad_synonym “sphingolipid intramembrane transporter activity”
sphingolipid intramembrane carrier activity term tracker item “https://github.com/geneontology/go-ontology/issues/31454”^^anyURI
sphingolipid intramembrane carrier activity label “sphingolipid intramembrane carrier activity”
sphingolipid intramembrane carrier activity SubClassOf intramembrane lipid carrier activity

sphingolipid transfer activity `http://purl.obolibrary.org/obo/GO_0120016`

Removed

sphingolipid transfer activity SubClassOf sphingolipid intramembrane carrier activity

sphingomyelin phosphodiesterase activity `http://purl.obolibrary.org/obo/GO_0004767`

Added

sphingomyelin phosphodiesterase activity narrowMatch 54284
sphingomyelin phosphodiesterase activity database_cross_reference “RHEA:45324”
sphingomyelin phosphodiesterase activity narrowMatch 45324
sphingomyelin phosphodiesterase activity database_cross_reference “RHEA:54284”

sphingomyelin synthase activity `http://purl.obolibrary.org/obo/GO_0033188`

Added

sphingomyelin synthase activity database_cross_reference “RHEA:43320”
sphingomyelin synthase activity narrowMatch 43320

sphingosine N-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0050291`

Added

sphingosine N-acyltransferase activity narrowMatch 64044
sphingosine N-acyltransferase activity narrowMatch 37115
sphingosine N-acyltransferase activity narrowMatch 45284
sphingosine N-acyltransferase activity database_cross_reference “RHEA:36687”
sphingosine N-acyltransferase activity narrowMatch 36687
sphingosine N-acyltransferase activity narrowMatch 37123
sphingosine N-acyltransferase activity database_cross_reference “RHEA:36691”
sphingosine N-acyltransferase activity database_cross_reference “RHEA:37115”
sphingosine N-acyltransferase activity database_cross_reference “RHEA:45284”
sphingosine N-acyltransferase activity database_cross_reference “RHEA:37123”
sphingosine N-acyltransferase activity database_cross_reference “RHEA:64044”
sphingosine N-acyltransferase activity narrowMatch 36691

sphingosine kinase activity `http://purl.obolibrary.org/obo/GO_0008481`

Added

sphingosine kinase activity database_cross_reference “RHEA:34747”
sphingosine kinase activity narrowMatch 34747
sphingosine kinase activity narrowMatch 63956
sphingosine kinase activity database_cross_reference “Reactome:R-HSA-9625814”
- label “SPHK1 phosphorylates sphingosine in response to E2 stimulation”
sphingosine kinase activity narrowMatch 15465
sphingosine kinase activity database_cross_reference “RHEA:63956”
sphingosine kinase activity narrowMatch 34715
sphingosine kinase activity database_cross_reference “RHEA:34715”
sphingosine kinase activity database_cross_reference “RHEA:33563”
sphingosine kinase activity database_cross_reference “Reactome:R-HSA-5218845”
- label “p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate”
sphingosine kinase activity database_cross_reference “RHEA:35847”
sphingosine kinase activity database_cross_reference “RHEA:15465”
sphingosine kinase activity narrowMatch 35847
sphingosine kinase activity narrowMatch 33563

spindle organization `http://purl.obolibrary.org/obo/GO_0007051`

Removed

spindle organization definition “A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:go_curators”

Added

spindle organization definition “A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:curators”

squalene synthase [NAD(P)H] activity `http://purl.obolibrary.org/obo/GO_0051996`

Added

squalene synthase [NAD(P)H] activity database_cross_reference “Reactome:R-HSA-191405”
- label “Two FAPP molecules dimerize to form presqualene diphosphate”
squalene synthase [NAD(P)H] activity database_cross_reference “Reactome:R-HSA-191402”
- label “Reduction of presqualene diphosphate to form squalene”

stamen development `http://purl.obolibrary.org/obo/GO_0048443`

Removed

stamen development definition “The process whose specific outcome is the progression of the stamen over time, from its formation to the mature structure.”
- database_cross_reference “GOC:go_curators”

Added

stamen development definition “The process whose specific outcome is the progression of the stamen over time, from its formation to the mature structure.”
- database_cross_reference “GOC:curators”

stamen morphogenesis `http://purl.obolibrary.org/obo/GO_0048448`

Removed

stamen morphogenesis definition “The process in which the anatomical structures of the stamen are generated and organized.”
- database_cross_reference “GOC:go_curators”

Added

stamen morphogenesis definition “The process in which the anatomical structures of the stamen are generated and organized.”
- database_cross_reference “GOC:curators”

starch catabolic process `http://purl.obolibrary.org/obo/GO_0005983`

Added

starch catabolic process narrowMatch PWY-842
starch catabolic process database_cross_reference “MetaCyc:PWY-6735”
starch catabolic process database_cross_reference “MetaCyc:PWY-6731”
starch catabolic process narrowMatch PWY-6724
starch catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
starch catabolic process database_cross_reference “MetaCyc:PWY-6724”
starch catabolic process narrowMatch PWY-6737
starch catabolic process narrowMatch PWY-6731
starch catabolic process narrowMatch PWY-6735
starch catabolic process database_cross_reference “MetaCyc:PWY-6737”

starch utilization system complex `http://purl.obolibrary.org/obo/GO_0044570`

Added

starch utilization system complex SubClassOf extracellular protein-containing complex

stereocilium coat `http://purl.obolibrary.org/obo/GO_0120234`

Removed

stereocilium coat SubClassOf part of some stereocilium

Added

stereocilium coat term tracker item “https://github.com/geneontology/go-ontology/issues/31720”^^anyURI

sterigmatocystin catabolic process `http://purl.obolibrary.org/obo/GO_0045574`

Removed

sterigmatocystin catabolic process definition “The chemical reactions and pathways resulting in the breakdown of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds.”
- database_cross_reference “GOC:go_curators”

Added

sterigmatocystin catabolic process definition “The chemical reactions and pathways resulting in the breakdown of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds.”
- database_cross_reference “GOC:curators”

steroid 11-beta-monooxygenase activity `http://purl.obolibrary.org/obo/GO_0004507`

Added

steroid 11-beta-monooxygenase activity database_cross_reference “RHEA:84071”
steroid 11-beta-monooxygenase activity database_cross_reference “RHEA:46104”
steroid 11-beta-monooxygenase activity narrowMatch 46100
steroid 11-beta-monooxygenase activity narrowMatch 84071
steroid 11-beta-monooxygenase activity database_cross_reference “RHEA:46100”
steroid 11-beta-monooxygenase activity database_cross_reference “RHEA:84067”
steroid 11-beta-monooxygenase activity narrowMatch 84067
steroid 11-beta-monooxygenase activity narrowMatch 46104

steroid 15-alpha-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0008388`

Added

steroid 15-alpha-hydroxylase activity database_cross_reference “RHEA:83131”
steroid 15-alpha-hydroxylase activity narrowMatch 83131
steroid 15-alpha-hydroxylase activity narrowMatch 83167
steroid 15-alpha-hydroxylase activity narrowMatch 83163
steroid 15-alpha-hydroxylase activity database_cross_reference “RHEA:83163”
steroid 15-alpha-hydroxylase activity database_cross_reference “RHEA:83167”

steroid 17-alpha-monooxygenase activity `http://purl.obolibrary.org/obo/GO_0004508`

Added

steroid 17-alpha-monooxygenase activity narrowMatch 50244
steroid 17-alpha-monooxygenase activity narrowMatch 84243
steroid 17-alpha-monooxygenase activity database_cross_reference “RHEA:46308”
steroid 17-alpha-monooxygenase activity database_cross_reference “RHEA:14753”
steroid 17-alpha-monooxygenase activity database_cross_reference “RHEA:50236”
steroid 17-alpha-monooxygenase activity narrowMatch 50236
steroid 17-alpha-monooxygenase activity narrowMatch 14753
steroid 17-alpha-monooxygenase activity database_cross_reference “RHEA:50244”
steroid 17-alpha-monooxygenase activity database_cross_reference “RHEA:84243”
steroid 17-alpha-monooxygenase activity narrowMatch 46308

steroid Delta-isomerase activity `http://purl.obolibrary.org/obo/GO_0004769`

Added

steroid Delta-isomerase activity database_cross_reference “RHEA:43928”
steroid Delta-isomerase activity narrowMatch 43928
steroid Delta-isomerase activity narrowMatch 32187
steroid Delta-isomerase activity narrowMatch 43936
steroid Delta-isomerase activity database_cross_reference “RHEA:56936”
steroid Delta-isomerase activity database_cross_reference “RHEA:43936”
steroid Delta-isomerase activity narrowMatch 56936
steroid Delta-isomerase activity database_cross_reference “RHEA:32187”

steroid biosynthetic process `http://purl.obolibrary.org/obo/GO_0006694`

Removed

steroid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.”
- database_cross_reference “GOC:go_curators”

Added

steroid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.”
- database_cross_reference “GOC:curators”

steroid catabolic process `http://purl.obolibrary.org/obo/GO_0006706`

Removed

steroid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.”
- database_cross_reference “GOC:go_curators”

Added

steroid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.”
- database_cross_reference “GOC:curators”

steroid sulfotransferase activity `http://purl.obolibrary.org/obo/GO_0050294`

Added

steroid sulfotransferase activity database_cross_reference “RHEA:52372”
steroid sulfotransferase activity narrowMatch 52372

sterol 12-alpha-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0008397`

Added

sterol 12-alpha-hydroxylase activity database_cross_reference “Reactome:R-HSA-193845”
- label “CYP8B1 12-hydroxylates 4CHOL7a,27DONE”
sterol 12-alpha-hydroxylase activity database_cross_reference “Reactome:R-HSA-193709”
- label “CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL”
sterol 12-alpha-hydroxylase activity database_cross_reference “Reactome:R-HSA-192157”
- label “CYP8B1 12-hydroxylates 4CHOL7aOLONE”

sterol 14-demethylase activity `http://purl.obolibrary.org/obo/GO_0008398`

Added

sterol 14-demethylase activity database_cross_reference “Reactome:R-HSA-9947148”
- label “CYP51A1 14-demethylates 24,25-dhLAN to 4,4-diMeCholesta-8,14-dien-3-ol”
sterol 14-demethylase activity narrowMatch 75439
sterol 14-demethylase activity database_cross_reference “RHEA:75439”
sterol 14-demethylase activity narrowMatch 45960
sterol 14-demethylase activity database_cross_reference “RHEA:45960”

sterol 3-beta-glucosyltransferase activity `http://purl.obolibrary.org/obo/GO_0016906`

Added

sterol 3-beta-glucosyltransferase activity narrowMatch 61836
sterol 3-beta-glucosyltransferase activity database_cross_reference “RHEA:61848”
sterol 3-beta-glucosyltransferase activity narrowMatch 61848
sterol 3-beta-glucosyltransferase activity narrowMatch 61844
sterol 3-beta-glucosyltransferase activity database_cross_reference “RHEA:66280”
sterol 3-beta-glucosyltransferase activity database_cross_reference “RHEA:61836”
sterol 3-beta-glucosyltransferase activity narrowMatch 66284
sterol 3-beta-glucosyltransferase activity database_cross_reference “RHEA:61940”
sterol 3-beta-glucosyltransferase activity database_cross_reference “RHEA:61828”
sterol 3-beta-glucosyltransferase activity database_cross_reference “RHEA:61844”
sterol 3-beta-glucosyltransferase activity narrowMatch 61944
sterol 3-beta-glucosyltransferase activity database_cross_reference “RHEA:61944”
sterol 3-beta-glucosyltransferase activity narrowMatch 61812
sterol 3-beta-glucosyltransferase activity database_cross_reference “RHEA:61820”
sterol 3-beta-glucosyltransferase activity database_cross_reference “RHEA:61824”
sterol 3-beta-glucosyltransferase activity database_cross_reference “RHEA:61840”
sterol 3-beta-glucosyltransferase activity narrowMatch 66276
sterol 3-beta-glucosyltransferase activity narrowMatch 61840
sterol 3-beta-glucosyltransferase activity database_cross_reference “RHEA:61816”
sterol 3-beta-glucosyltransferase activity narrowMatch 61832
sterol 3-beta-glucosyltransferase activity database_cross_reference “RHEA:61832”
sterol 3-beta-glucosyltransferase activity database_cross_reference “RHEA:66284”
sterol 3-beta-glucosyltransferase activity database_cross_reference “RHEA:61852”
sterol 3-beta-glucosyltransferase activity narrowMatch 61816
sterol 3-beta-glucosyltransferase activity database_cross_reference “RHEA:61888”
sterol 3-beta-glucosyltransferase activity narrowMatch 61820
sterol 3-beta-glucosyltransferase activity narrowMatch 61888
sterol 3-beta-glucosyltransferase activity database_cross_reference “RHEA:61812”
sterol 3-beta-glucosyltransferase activity narrowMatch 66280
sterol 3-beta-glucosyltransferase activity narrowMatch 61824
sterol 3-beta-glucosyltransferase activity narrowMatch 61828
sterol 3-beta-glucosyltransferase activity narrowMatch 61940
sterol 3-beta-glucosyltransferase activity database_cross_reference “RHEA:66276”
sterol 3-beta-glucosyltransferase activity narrowMatch 61852

sterol biosynthetic process `http://purl.obolibrary.org/obo/GO_0016126`

Removed

sterol biosynthetic process definition “The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.”
- database_cross_reference “GOC:go_curators”

Added

sterol biosynthetic process definition “The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.”
- database_cross_reference “GOC:curators”

sterol catabolic process `http://purl.obolibrary.org/obo/GO_0016127`

Removed

sterol catabolic process definition “The chemical reactions and pathways resulting in the breakdown of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.”
- database_cross_reference “GOC:go_curators”

Added

sterol catabolic process definition “The chemical reactions and pathways resulting in the breakdown of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.”
- database_cross_reference “GOC:curators”

sterol ester esterase activity `http://purl.obolibrary.org/obo/GO_0004771`

Added

sterol ester esterase activity narrowMatch 36403
sterol ester esterase activity narrowMatch 33543
sterol ester esterase activity database_cross_reference “RHEA:36403”
sterol ester esterase activity database_cross_reference “RHEA:33547”
sterol ester esterase activity narrowMatch 33547
sterol ester esterase activity database_cross_reference “RHEA:33543”

stress fiber assembly `http://purl.obolibrary.org/obo/GO_0043149`

Removed

stress fiber assembly definition “The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:16651381”

Added

stress fiber assembly definition “The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:16651381”

stress response to acid chemical `http://purl.obolibrary.org/obo/GO_0097532`

Removed

stress response to acid chemical definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:aa”
- database_cross_reference “PMID:10615049”
- database_cross_reference “GOC:rl”
- database_cross_reference “Wikipedia:Acid”
- database_cross_reference “GOC:BHF”
- database_cross_reference “PMID:19170886”

Added

stress response to acid chemical definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:aa”
- database_cross_reference “PMID:10615049”
- database_cross_reference “GOC:rl”
- database_cross_reference “Wikipedia:Acid”
- database_cross_reference “GOC:BHF”
- database_cross_reference “PMID:19170886”

stromal side of plastid inner membrane `http://purl.obolibrary.org/obo/GO_0098570`

Removed

stromal side of plastid inner membrane definition “The side (leaflet) of the plastid inner membrane that faces the stroma, and any proteins embedded in it or loosely bound to its surface.”
- database_cross_reference “GOC:dos”

Added

stromal side of plastid inner membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
stromal side of plastid inner membrane definition “The leaflet of the plastid inner membrane that faces the stroma, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:dos”

stromal side of plastid thylakoid membrane `http://purl.obolibrary.org/obo/GO_0098572`

Removed

stromal side of plastid thylakoid membrane definition “The side (leaflet) of the plastid thylakoid membrane that faces the stroma, and any proteins embedded in it or loosely bound to its surface.”
- database_cross_reference “GOC:dos”

Added

stromal side of plastid thylakoid membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31515”^^anyURI
stromal side of plastid thylakoid membrane definition “The leaflet of the plastid thylakoid membrane that faces the stroma, including any protein embedded in, attached to, or peripherally associated with it.”
- database_cross_reference “GOC:dos”

structural constituent of nuclear pore `http://purl.obolibrary.org/obo/GO_0017056`

Removed

structural constituent of nuclear pore database_cross_reference “Reactome:R-HSA-170796”
- label “NPC transports GCK1:GKRP from cytosol to nucleoplasm”
structural constituent of nuclear pore database_cross_reference “Reactome:R-HSA-5578744”
- label “Importin-8 imports AGO2:miRNA into the nucleus”

Added

structural constituent of nuclear pore database_cross_reference “Reactome:R-HSA-170796”
- label “NPC transports GCK1:GCKR from cytosol to nucleoplasm”

succinate dehydrogenase (quinone) activity `http://purl.obolibrary.org/obo/GO_0008177`

Added

succinate dehydrogenase (quinone) activity database_cross_reference “RHEA:27834”
succinate dehydrogenase (quinone) activity narrowMatch 75711
succinate dehydrogenase (quinone) activity narrowMatch 13713
succinate dehydrogenase (quinone) activity database_cross_reference “RHEA:13713”
succinate dehydrogenase (quinone) activity narrowMatch 27834
succinate dehydrogenase (quinone) activity database_cross_reference “RHEA:75711”

succinate dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0000104`

Added

succinate dehydrogenase activity narrowMatch 51848
succinate dehydrogenase activity database_cross_reference “RHEA:51848”

succinate-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0004774`

Removed

succinate-CoA ligase activity SubClassOf acid-thiol ligase activity

Added

succinate-CoA ligase activity SubClassOf CoA-ligase activity

succinyldiaminopimelate:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0009016`

Removed

succinyldiaminopimelate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + N-succinyl-LL-2,6-diaminopimelate = L-2-succinylamino-6-oxopimelate + L-glutamate.”
- database_cross_reference “RHEA:11960”
- database_cross_reference “EC:2.6.1.17”
succinyldiaminopimelate:2-oxoglutarate transaminase activity label “succinyldiaminopimelate transaminase activity”

Added

succinyldiaminopimelate:2-oxoglutarate transaminase activity label “succinyldiaminopimelate:2-oxoglutarate transaminase activity”
succinyldiaminopimelate:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: N-succinyl-(2S,6S)-2,6-diaminopimelate + 2-oxoglutarate = (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate.”
- database_cross_reference “RHEA:11960”
succinyldiaminopimelate:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
succinyldiaminopimelate:2-oxoglutarate transaminase activity has_exact_synonym “succinyldiaminopimelate transaminase activity”

succinylornithine:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0043825`

Removed

succinylornithine:2-oxoglutarate transaminase activity label “succinylornithine transaminase activity”
succinylornithine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + N(2)-succinyl-L-ornithine = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate.”
- database_cross_reference “RHEA:16953”
- database_cross_reference “EC:2.6.1.81”

Added

succinylornithine:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: N(2)-succinyl-L-ornithine + 2-oxoglutarate = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate.”
- database_cross_reference “RHEA:16953”
succinylornithine:2-oxoglutarate transaminase activity has_exact_synonym “succinylornithine transaminase activity”
succinylornithine:2-oxoglutarate transaminase activity label “succinylornithine:2-oxoglutarate transaminase activity”
succinylornithine:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI

sucrose biosynthetic process `http://purl.obolibrary.org/obo/GO_0005986`

Removed

sucrose biosynthetic process definition “The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside.”
- database_cross_reference “GOC:go_curators”

Added

sucrose biosynthetic process narrowMatch PWY-7238
sucrose biosynthetic process narrowMatch PWY-7347
sucrose biosynthetic process definition “The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside.”
- database_cross_reference “GOC:curators”
sucrose biosynthetic process narrowMatch SUCSYN-PWY
sucrose biosynthetic process database_cross_reference “MetaCyc:PWY-7238”
sucrose biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
sucrose biosynthetic process database_cross_reference “MetaCyc:PWY-7347”

sucrose catabolic process `http://purl.obolibrary.org/obo/GO_0005987`

Removed

sucrose catabolic process definition “The chemical reactions and pathways resulting in the breakdown of sucrose, the disaccharide fructofuranosyl-glucopyranoside.”
- database_cross_reference “GOC:go_curators”

Added

sucrose catabolic process definition “The chemical reactions and pathways resulting in the breakdown of sucrose, the disaccharide fructofuranosyl-glucopyranoside.”
- database_cross_reference “GOC:curators”

sucrose metabolic process `http://purl.obolibrary.org/obo/GO_0005985`

Removed

sucrose metabolic process definition “The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside.”
- database_cross_reference “GOC:go_curators”

Added

sucrose metabolic process definition “The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside.”
- database_cross_reference “GOC:curators”

sucrose synthase activity `http://purl.obolibrary.org/obo/GO_0016157`

Added

sucrose synthase activity narrowMatch 55080
sucrose synthase activity database_cross_reference “RHEA:55092”
sucrose synthase activity narrowMatch 55092
sucrose synthase activity database_cross_reference “RHEA:55080”

sulfate transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015116`

Removed

sulfate transmembrane transporter activity database_cross_reference “Reactome:R-HSA-427555”
- label “SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol”

Added

sulfate transmembrane transporter activity database_cross_reference “Reactome:R-HSA-427555”
- label “SLC26A1,2 cotransport SO4(2-), anion from extracellular region to cytosol”
sulfate transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9941470”
- label “SLC26A11 imports SO4(2-) and H+ into cytosol”

sulfite oxidase activity `http://purl.obolibrary.org/obo/GO_0008482`

Removed

sulfite oxidase activity comment “Note that this term has a MetaCyc pathway reference as the pathway only has a single step.”
sulfite oxidase activity relatedMatch PWY-5326

Added

sulfite oxidase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI

sulfite reductase (NADPH) activity `http://purl.obolibrary.org/obo/GO_0004783`

Removed

sulfite reductase (NADPH) activity SubClassOf obsolete obsolete sulfite reductase activity

sulfite reductase (coenzyme F420) activity `http://purl.obolibrary.org/obo/GO_0052806`

Removed

sulfite reductase (coenzyme F420) activity SubClassOf obsolete obsolete sulfite reductase activity

Added

sulfite reductase (coenzyme F420) activity SubClassOf oxidoreductase activity, acting on a sulfur group of donors

sulfur amino acid biosynthetic process `http://purl.obolibrary.org/obo/GO_0000097`

Removed

sulfur amino acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine.”
- database_cross_reference “GOC:ai”

Added

sulfur amino acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of amino acids containing sulfur.”
- database_cross_reference “GOC:curators”
sulfur amino acid biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31500”^^anyURI

sulfur amino acid catabolic process `http://purl.obolibrary.org/obo/GO_0000098`

Removed

sulfur amino acid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine.”
- database_cross_reference “GOC:ai”

Added

sulfur amino acid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur.”
- database_cross_reference “GOC:curators”
sulfur amino acid catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31500”^^anyURI

sulfur amino acid metabolic process `http://purl.obolibrary.org/obo/GO_0000096`

Removed

sulfur amino acid metabolic process definition “The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine.”
- database_cross_reference “GOC:ai”

Added

sulfur amino acid metabolic process definition “The chemical reactions and pathways involving amino acids containing sulfur.”
- database_cross_reference “GOC:curators”
sulfur amino acid metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31500”^^anyURI

sulfurated eukaryotic molybdenum cofactor(2-) biosynthetic process `http://purl.obolibrary.org/obo/GO_1902756`

Removed

Added

sulfurated eukaryotic molybdenum cofactor(2-) biosynthetic process SubClassOf Mo-molybdopterin cofactor biosynthetic process

sulfurtransferase activity `http://purl.obolibrary.org/obo/GO_0016783`

Added

sulfurtransferase activity database_cross_reference “Reactome:R-HSA-9034756”
- label “MPST transfers sulfur atom from 3MPYR to form CysS248-MPST”
sulfurtransferase activity database_cross_reference “Reactome:R-HSA-9012721”
- label “MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR”
sulfurtransferase activity database_cross_reference “Reactome:R-HSA-9013533”
- label “MPST transfers sulfur from sulfanegen to HCN to form HSCN”
sulfurtransferase activity database_cross_reference “Reactome:R-HSA-9013471”
- label “MPST transfers sulfur from 3MPYR to HCN to form HSCN”

superoxide dismutase activity `http://purl.obolibrary.org/obo/GO_0004784`

Removed

superoxide dismutase activity definition “Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.”
- database_cross_reference “PMID:15064408”
- database_cross_reference “GOC:vw”
- database_cross_reference “EC:1.15.1.1”

Added

superoxide dismutase activity definition “Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + H2O2.”
- database_cross_reference “PMID:15064408”
- database_cross_reference “GOC:vw”
- database_cross_reference “EC:1.15.1.1”

symbiont-mediated induction of syncytium formation `http://purl.obolibrary.org/obo/GO_0060141`

Added

symbiont-mediated induction of syncytium formation database_cross_reference “Reactome:R-HSA-9733458”
- label “Induction of Cell-Cell Fusion”

symbiont-mediated perturbation of host apoptosis `http://purl.obolibrary.org/obo/GO_0052150`

Removed

symbiont-mediated perturbation of host apoptosis SubClassOf regulation of killing of cells of another organism

Added

symbiont-mediated perturbation of host apoptosis database_cross_reference “Reactome:R-HSA-9920951”
- label “Dengue virus modulates apoptosis”

symbiont-mediated perturbation of host immune response `http://purl.obolibrary.org/obo/GO_0052553`

Added

symbiont-mediated perturbation of host immune response database_cross_reference “Reactome:R-HSA-9920588”
- label “Dengue virus activates/modulates innate and adaptive immune responses”

symbiont-mediated perturbation of host process `http://purl.obolibrary.org/obo/GO_0044003`

Added

symbiont-mediated perturbation of host process database_cross_reference “Reactome:R-HSA-9918481”
- label “Dengue Virus-Host Interactions”
symbiont-mediated perturbation of host process database_cross_reference “Reactome:R-HSA-9833110”
- label “RSV-host interactions”

symbiont-mediated suppression of host programmed cell death `http://purl.obolibrary.org/obo/GO_0052041`

Added

symbiont-mediated suppression of host programmed cell death database_cross_reference “Reactome:R-HSA-9636569”
- label “Suppression of autophagy”

synaptic cleft `http://purl.obolibrary.org/obo/GO_0043083`

Removed

synaptic cleft SubClassOf extracellular region

Added

synaptic cleft term tracker item “https://github.com/geneontology/go-ontology/issues/31720”^^anyURI
synaptic cleft SubClassOf part of some extracellular region
synaptic cleft SubClassOf cellular anatomical structure

synaptic vesicle lumen acidification `http://purl.obolibrary.org/obo/GO_0097401`

Added

synaptic vesicle lumen acidification SubClassOf intercellular transport

syncytium formation by cell-cell fusion `http://purl.obolibrary.org/obo/GO_0000768`

Removed

syncytium formation by cell-cell fusion has_broad_synonym “cell fusion”
syncytium formation by cell-cell fusion label “syncytium formation by plasma membrane fusion”
syncytium formation by cell-cell fusion EquivalentTo obsolete syncytium formation and (has part some obsolete plasma membrane fusion)
syncytium formation by cell-cell fusion SubClassOf obsolete syncytium formation

Added

syncytium formation by cell-cell fusion term tracker item “https://github.com/geneontology/go-ontology/issues/31270”^^anyURI
syncytium formation by cell-cell fusion has_exact_synonym “syncytium formation by plasma membrane fusion”
syncytium formation by cell-cell fusion label “syncytium formation by cell-cell fusion”

syncytium formation by mitosis without cytokinesis `http://purl.obolibrary.org/obo/GO_0000769`

Removed

syncytium formation by mitosis without cytokinesis EquivalentTo obsolete syncytium formation and (has part some cell cycle comprising mitosis without cytokinesis)
syncytium formation by mitosis without cytokinesis SubClassOf has part some cell cycle comprising mitosis without cytokinesis
syncytium formation by mitosis without cytokinesis SubClassOf obsolete syncytium formation

Added

syncytium formation by mitosis without cytokinesis term tracker item “https://github.com/geneontology/go-ontology/issues/31270”^^anyURI
syncytium formation by mitosis without cytokinesis SubClassOf cell cycle comprising mitosis without cytokinesis

syndecan binding `http://purl.obolibrary.org/obo/GO_0045545`

Removed

syndecan binding definition “Binding to syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:9355727”

Added

syndecan binding definition “Binding to syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:9355727”

syntaxin binding `http://purl.obolibrary.org/obo/GO_0019905`

Removed

syntaxin binding has_narrow_synonym “syntaxin-2 binding”
syntaxin binding has_narrow_synonym “syntaxin-13 binding”
syntaxin binding definition “Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.”
- database_cross_reference “ISBN:0198506732”
syntaxin binding has_narrow_synonym “syntaxin-6 binding”
syntaxin binding has_narrow_synonym “syntaxin-5 binding”

Added

syntaxin binding term tracker item “https://github.com/geneontology/go-ontology/issues/31404”^^anyURI
syntaxin binding definition “Binding to a syntaxin, a SNAP receptor involved in the docking of vesicles.”
- database_cross_reference “ISBN:0198506732”

tRNA (5-carboxymethoxyuridine(34)-5-O)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0097697`

Removed

tRNA (5-carboxymethoxyuridine(34)-5-O)-methyltransferase activity definition “Catalysis of the reaction: 5-carboxymethoxyuridine34 in tRNA + S-adenosyl-L-methionine = 5-methoxycarbonylmethoxyuridine34 in tRNA + S-adenosyl-L-homocysteine.”
- database_cross_reference “RHEA:54080”
- database_cross_reference “PMID:26681692”

Added

tRNA (5-carboxymethoxyuridine(34)-5-O)-methyltransferase activity definition “Catalysis of the reaction: 5-carboxymethoxyuridine34 in tRNA + S-adenosyl-L-methionine = 5-methoxycarbonylmethoxyuridine34 in tRNA + S-adenosyl-L-homocysteine. The methylation occurs on the modified base.”
- database_cross_reference “RHEA:54080”
- database_cross_reference “PMID:26681692”

tRNA (5-carboxymethylaminomethyluridine(34)-2’-O-ribose)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0141102`

Removed

tRNA (5-carboxymethylaminomethyluridine(34)-2’-O-ribose)-methyltransferase activity label “tRNA (5-carboxymethylaminomethyluridine(34)-2’-O)-methyltransferase activity”

Added

tRNA (5-carboxymethylaminomethyluridine(34)-2’-O-ribose)-methyltransferase activity label “tRNA (5-carboxymethylaminomethyluridine(34)-2’-O-ribose)-methyltransferase activity”
tRNA (5-carboxymethylaminomethyluridine(34)-2’-O-ribose)-methyltransferase activity has_exact_synonym “tRNA (5-carboxymethylaminomethyluridine(34)-2’-O)-methyltransferase activity”

tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0106335`

Removed

tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity definition “Catalysis of the reaction: 5-(carboxymethyl)uridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine.”
- database_cross_reference “PMID:20123966”
- database_cross_reference “RHEA:43208”

Added

tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity definition “Catalysis of the reaction: 5-(carboxymethyl)uridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine. The methylation occurs on the modified base.”
- database_cross_reference “PMID:20123966”
- database_cross_reference “RHEA:43208”

tRNA (adenine) methyltransferase activity `http://purl.obolibrary.org/obo/GO_0016426`

Removed

tRNA (adenine) methyltransferase activity definition “Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methyladenine.”
- database_cross_reference “GOC:go-curators”

Added

tRNA (adenine) methyltransferase activity definition “Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methyladenine.”
- database_cross_reference “GOC:curators”

tRNA (cytidine(32)-2’-O-ribose)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0106339`

Removed

tRNA (cytidine(32)-2’-O-ribose)-methyltransferase activity label “tRNA (cytidine(32)-2’-O)-methyltransferase activity”

Added

tRNA (cytidine(32)-2’-O-ribose)-methyltransferase activity has_exact_synonym “tRNA (cytidine(32)-2’-O)-methyltransferase activity”
tRNA (cytidine(32)-2’-O-ribose)-methyltransferase activity label “tRNA (cytidine(32)-2’-O-ribose)-methyltransferase activity”

tRNA (cytidine(32)/uridine(32)-2’-O-ribose)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0160206`

Removed

tRNA (cytidine(32)/uridine(32)-2’-O-ribose)-methyltransferase activity label “tRNA (cytidine(32)/uridine(32)-2’-O)-methyltransferase activity”

Added

tRNA (cytidine(32)/uridine(32)-2’-O-ribose)-methyltransferase activity has_exact_synonym “tRNA (cytidine(32)/uridine(32)-2’-O)-methyltransferase activity”
tRNA (cytidine(32)/uridine(32)-2’-O-ribose)-methyltransferase activity label “tRNA (cytidine(32)/uridine(32)-2’-O-ribose)-methyltransferase activity”

tRNA (cytidine(34)-2’-O-ribose)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0141098`

Removed

tRNA (cytidine(34)-2’-O-ribose)-methyltransferase activity label “tRNA (cytidine(34)-2’-O)-methyltransferase activity”

Added

tRNA (cytidine(34)-2’-O-ribose)-methyltransferase activity has_exact_synonym “tRNA (cytidine(34)-2’-O)-methyltransferase activity”
tRNA (cytidine(34)-2’-O-ribose)-methyltransferase activity label “tRNA (cytidine(34)-2’-O-ribose)-methyltransferase activity”

tRNA (cytidine(4)/adenine(4)-2’-O-ribose)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0140386`

Added

tRNA (cytidine(4)/adenine(4)-2’-O-ribose)-methyltransferase activity database_cross_reference “RHEA:43192”
tRNA (cytidine(4)/adenine(4)-2’-O-ribose)-methyltransferase activity id “GO:0140386”
tRNA (cytidine(4)/adenine(4)-2’-O-ribose)-methyltransferase activity database_cross_reference “EC:2.1.1.225”
tRNA (cytidine(4)/adenine(4)-2’-O-ribose)-methyltransferase activity database_cross_reference “RHEA:43196”
tRNA (cytidine(4)/adenine(4)-2’-O-ribose)-methyltransferase activity narrowMatch 43196
tRNA (cytidine(4)/adenine(4)-2’-O-ribose)-methyltransferase activity has_obo_namespace “molecular_function”
tRNA (cytidine(4)/adenine(4)-2’-O-ribose)-methyltransferase activity database_cross_reference “RHEA:32767”
tRNA (cytidine(4)/adenine(4)-2’-O-ribose)-methyltransferase activity narrowMatch 43192
tRNA (cytidine(4)/adenine(4)-2’-O-ribose)-methyltransferase activity definition “Catalysis of the reaction: cytidine(4) in tRNA + S-adenosyl-L-methionine = 2’-O-methylcytidine(4) in tRNA + S-adenosyl-L-homocysteine + H+. Acts on cytidine(4) on tRNAPro and tRNAGly(GCC), and on adenosine(4) in tRNAHis.”
- database_cross_reference “PMID:17242307”
- database_cross_reference “EC:2.1.1.225”
tRNA (cytidine(4)/adenine(4)-2’-O-ribose)-methyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31521”^^anyURI
tRNA (cytidine(4)/adenine(4)-2’-O-ribose)-methyltransferase activity exactMatch 2.1.1.225
tRNA (cytidine(4)/adenine(4)-2’-O-ribose)-methyltransferase activity label “tRNA (cytidine(4)/adenine(4)-2’-O-ribose)-methyltransferase activity”
tRNA (cytidine(4)/adenine(4)-2’-O-ribose)-methyltransferase activity created by “pg”
tRNA (cytidine(4)/adenine(4)-2’-O-ribose)-methyltransferase activity creation date “2026-02-06T12:44:45Z”
tRNA (cytidine(4)/adenine(4)-2’-O-ribose)-methyltransferase activity narrowMatch 32767
Class: tRNA (cytidine(4)/adenine(4)-2’-O-ribose)-methyltransferase activity
tRNA (cytidine(4)/adenine(4)-2’-O-ribose)-methyltransferase activity SubClassOf tRNA (cytidine) methyltransferase activity
tRNA (cytidine(4)/adenine(4)-2’-O-ribose)-methyltransferase activity SubClassOf tRNA (adenine) methyltransferase activity

tRNA (cytidine(56)-2’-O-ribose)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0106059`

Removed

tRNA (cytidine(56)-2’-O-ribose)-methyltransferase activity label “tRNA (cytidine(56)-2’-O)-methyltransferase activity”

Added

tRNA (cytidine(56)-2’-O-ribose)-methyltransferase activity label “tRNA (cytidine(56)-2’-O-ribose)-methyltransferase activity”
tRNA (cytidine(56)-2’-O-ribose)-methyltransferase activity has_exact_synonym “tRNA (cytidine(56)-2’-O)-methyltransferase activity”

tRNA (cytidine) methyltransferase activity `http://purl.obolibrary.org/obo/GO_0016427`

Removed

tRNA (cytidine) methyltransferase activity definition “Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine.”
- database_cross_reference “GOC:go-curators”

Added

tRNA (cytidine) methyltransferase activity definition “Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine.”
- database_cross_reference “GOC:curators”

tRNA (cytidine-N3)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0052735`

Removed

tRNA (cytidine-N3)-methyltransferase activity label “tRNA (cytidine-3-)-methyltransferase activity”

Added

tRNA (cytidine-N3)-methyltransferase activity database_cross_reference “RHEA:60912”
tRNA (cytidine-N3)-methyltransferase activity narrowMatch 60912
tRNA (cytidine-N3)-methyltransferase activity database_cross_reference “RHEA:50956”
tRNA (cytidine-N3)-methyltransferase activity label “tRNA (cytidine-N3)-methyltransferase activity”
tRNA (cytidine-N3)-methyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/26109”^^anyURI
tRNA (cytidine-N3)-methyltransferase activity narrowMatch 50960
tRNA (cytidine-N3)-methyltransferase activity has_exact_synonym “tRNA (cytidine-3-)-methyltransferase activity”
tRNA (cytidine-N3)-methyltransferase activity database_cross_reference “RHEA:50960”
tRNA (cytidine-N3)-methyltransferase activity narrowMatch 50956

tRNA (cytidine-N5)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0016428`

Removed

tRNA (cytidine-N5)-methyltransferase activity relatedMatch 2.1.1.202
tRNA (cytidine-N5)-methyltransferase activity definition “Catalysis of the reaction: a cytidine in tRNA + S-adenosyl-L-methionine = a 5-methylcytidine in tRNA + S-adenosyl-L-homocysteine + H+. This modification can occur on seversal residues, including cytidine(34), cytidine(40), cytidine(48), and cytidine(49).”
- database_cross_reference “RHEA:61468”
tRNA (cytidine-N5)-methyltransferase activity label “tRNA (cytidine-5-)-methyltransferase activity”

Added

tRNA (cytidine-N5)-methyltransferase activity database_cross_reference “RHEA:42944”
tRNA (cytidine-N5)-methyltransferase activity narrowMatch 53076
tRNA (cytidine-N5)-methyltransferase activity narrowMatch 51164
tRNA (cytidine-N5)-methyltransferase activity definition “Catalysis of the reaction: a cytidine in tRNA + S-adenosyl-L-methionine = a 5-methylcytidine in tRNA + S-adenosyl-L-homocysteine + H+. This modification can occur on several residues, including cytidine(34), cytidine(40), cytidine(48), and cytidine(49).”
- database_cross_reference “RHEA:61468”
tRNA (cytidine-N5)-methyltransferase activity database_cross_reference “RHEA:42940”
tRNA (cytidine-N5)-methyltransferase activity narrowMatch 42944
tRNA (cytidine-N5)-methyltransferase activity database_cross_reference “RHEA:51164”
tRNA (cytidine-N5)-methyltransferase activity database_cross_reference “RHEA:54140”
tRNA (cytidine-N5)-methyltransferase activity database_cross_reference “RHEA:61988”
tRNA (cytidine-N5)-methyltransferase activity narrowMatch 54140
tRNA (cytidine-N5)-methyltransferase activity narrowMatch 51180
tRNA (cytidine-N5)-methyltransferase activity narrowMatch 42948
tRNA (cytidine-N5)-methyltransferase activity narrowMatch 61988
tRNA (cytidine-N5)-methyltransferase activity narrowMatch 42956
tRNA (cytidine-N5)-methyltransferase activity database_cross_reference “RHEA:51172”
tRNA (cytidine-N5)-methyltransferase activity narrowMatch 51160
tRNA (cytidine-N5)-methyltransferase activity database_cross_reference “RHEA:42948”
tRNA (cytidine-N5)-methyltransferase activity narrowMatch 61488
tRNA (cytidine-N5)-methyltransferase activity database_cross_reference “RHEA:61488”
tRNA (cytidine-N5)-methyltransferase activity narrowMatch 42940
tRNA (cytidine-N5)-methyltransferase activity has_exact_synonym “tRNA (cytidine-5-)-methyltransferase activity”
tRNA (cytidine-N5)-methyltransferase activity database_cross_reference “RHEA:42956”
tRNA (cytidine-N5)-methyltransferase activity database_cross_reference “RHEA:53076”
tRNA (cytidine-N5)-methyltransferase activity database_cross_reference “RHEA:42952”
tRNA (cytidine-N5)-methyltransferase activity database_cross_reference “RHEA:51180”
tRNA (cytidine-N5)-methyltransferase activity database_cross_reference “RHEA:51160”
tRNA (cytidine-N5)-methyltransferase activity narrowMatch 2.1.1.202
tRNA (cytidine-N5)-methyltransferase activity narrowMatch 51172
tRNA (cytidine-N5)-methyltransferase activity narrowMatch 54136
tRNA (cytidine-N5)-methyltransferase activity narrowMatch 42952
tRNA (cytidine-N5)-methyltransferase activity label “tRNA (cytidine-N5)-methyltransferase activity”
tRNA (cytidine-N5)-methyltransferase activity database_cross_reference “RHEA:54136”
tRNA (cytidine-N5)-methyltransferase activity database_cross_reference “EC:2.1.1.202”
tRNA (cytidine-N5)-methyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/26109”^^anyURI

tRNA (guanine(18)-2’-O-ribose)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0141100`

Removed

tRNA (guanine(18)-2’-O-ribose)-methyltransferase activity label “tRNA (guanine(18)-2’-O)-methyltransferase activity”

Added

tRNA (guanine(18)-2’-O-ribose)-methyltransferase activity label “tRNA (guanine(18)-2’-O-ribose)-methyltransferase activity”
tRNA (guanine(18)-2’-O-ribose)-methyltransferase activity has_exact_synonym “tRNA (guanine(18)-2’-O-)-methyltransferase activity”

tRNA (guanine) methyltransferase activity `http://purl.obolibrary.org/obo/GO_0016423`

Removed

tRNA (guanine) methyltransferase activity definition “Catalysis of the reaction: S-adenosyl-L-methionine + guanosine in tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine.”
- database_cross_reference “GOC:go-curators”

Added

tRNA (guanine) methyltransferase activity definition “Catalysis of the reaction: S-adenosyl-L-methionine + guanosine in tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine.”
- database_cross_reference “GOC:curators”

tRNA (guanosine(34)-2’-O-ribose)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0106340`

Removed

tRNA (guanosine(34)-2’-O-ribose)-methyltransferase activity label “tRNA (guanosine(34)-2’-O)-methyltransferase activity”
tRNA (guanosine(34)-2’-O-ribose)-methyltransferase activity definition “Catalysis of the reaction: guanosine(34) in tRNA + S-adenosyl-L-methionine = 2’-O-methylguanosine(34) in tRNA + H+ + S-adenosyl-L-homocysteine.”
- database_cross_reference “PMID:31943105”

Added

tRNA (guanosine(34)-2’-O-ribose)-methyltransferase activity exactMatch 85171
tRNA (guanosine(34)-2’-O-ribose)-methyltransferase activity label “tRNA (guanosine(34)-2’-O-ribose)-methyltransferase activity”
tRNA (guanosine(34)-2’-O-ribose)-methyltransferase activity has_exact_synonym “tRNA (guanosine(34)-2’-O)-methyltransferase activity”
tRNA (guanosine(34)-2’-O-ribose)-methyltransferase activity database_cross_reference “RHEA:85171”
tRNA (guanosine(34)-2’-O-ribose)-methyltransferase activity definition “Catalysis of the reaction: guanosine(34) in tRNA + S-adenosyl-L-methionine = 2’-O-methylguanosine(34) in tRNA + H+ + S-adenosyl-L-homocysteine.”
- database_cross_reference “RHEA:85171”
- database_cross_reference “PMID:31943105”

tRNA (uracil(54)-C5)-methyltransferase activity, 5,10-methylenetetrahydrofolate-dependent `http://purl.obolibrary.org/obo/GO_0047151`

Removed

tRNA (uracil(54)-C5)-methyltransferase activity, 5,10-methylenetetrahydrofolate-dependent definition “Catalysis of the reaction: 5,10-methylenetetrahydrofolate + tRNA containing uridine at position 54 + FADH + H+ = tetrahydrofolate + tRNA containing ribothymidine at position 54 + FAD+.”
- database_cross_reference “EC:2.1.1.74”
- database_cross_reference “MetaCyc:2.1.1.74-RXN”
tRNA (uracil(54)-C5)-methyltransferase activity, 5,10-methylenetetrahydrofolate-dependent exactMatch 16873

Added

tRNA (uracil(54)-C5)-methyltransferase activity, 5,10-methylenetetrahydrofolate-dependent database_cross_reference “RHEA:62372”
tRNA (uracil(54)-C5)-methyltransferase activity, 5,10-methylenetetrahydrofolate-dependent definition “Catalysis of the reaction: uridine54 in tRNA + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(P)H + H+ = 5-methyluridine54 in tRNA + (6S)-5,6,7,8-tetrahydrofolate + NAD(P)+.”
- database_cross_reference “EC:2.1.1.74”
tRNA (uracil(54)-C5)-methyltransferase activity, 5,10-methylenetetrahydrofolate-dependent narrowMatch 16873
tRNA (uracil(54)-C5)-methyltransferase activity, 5,10-methylenetetrahydrofolate-dependent narrowMatch 62372

tRNA 3’-end processing `http://purl.obolibrary.org/obo/GO_0042780`

Removed

tRNA 3’-end processing definition “The process in which the 3’ end of a pre-tRNA molecule is converted to that of a mature tRNA.”
- database_cross_reference “GOC:go_curators”

Added

tRNA 3’-end processing definition “The process in which the 3’ end of a pre-tRNA molecule is converted to that of a mature tRNA.”
- database_cross_reference “GOC:curators”

tRNA 3’-terminal CCA addition `http://purl.obolibrary.org/obo/GO_0001680`

Removed

tRNA 3’-terminal CCA addition definition “Post-transcriptional addition of the terminal 3’ CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3’ end of the tRNA, yielding a diphosphate with each nucleotide addition.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:2247609”

Added

tRNA 3’-terminal CCA addition definition “Post-transcriptional addition of the terminal 3’ CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3’ end of the tRNA, yielding a diphosphate with each nucleotide addition.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:2247609”

tRNA N(6)-L-threonylcarbamoyladenine synthase activity `http://purl.obolibrary.org/obo/GO_0061711`

Removed

tRNA N(6)-L-threonylcarbamoyladenine synthase activity database_cross_reference “Reactome:R-HSA-6784494”
- label “EKC complex threonylcarbamoylates A37 of tRNAs”

Added

tRNA N(6)-L-threonylcarbamoyladenine synthase activity database_cross_reference “Reactome:R-HSA-9611197”
- label “OSGEPL1 threonylcarbamoylates adenosine-37 in tRNA”
tRNA N(6)-L-threonylcarbamoyladenine synthase activity database_cross_reference “Reactome:R-HSA-6784494”
- label “KEOPS (EKC) complex threonylcarbamoylates A37 of tRNAs”

tRNA binding `http://purl.obolibrary.org/obo/GO_0000049`

Added

tRNA binding database_cross_reference “Reactome:R-HSA-2408509”
- label “Sec-tRNA(Sec) binds to EEFSEC:GTP”

tRNA cytidine N4-acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0051392`

Added

tRNA end turnover `http://purl.obolibrary.org/obo/GO_0042778`

Removed

tRNA end turnover definition “The process in which the 3’-terminal CCA of a tRNA is removed and restored. This often happens to uncharged tRNA.”
- database_cross_reference “GOC:go_curators”

Added

tRNA end turnover definition “The process in which the 3’-terminal CCA of a tRNA is removed and restored. This often happens to uncharged tRNA.”
- database_cross_reference “GOC:curators”

tRNA methyltransferase activity `http://purl.obolibrary.org/obo/GO_0008175`

Removed

tRNA methyltransferase activity definition “Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule.”
- database_cross_reference “GOC:mah”

Added

tRNA methyltransferase activity definition “Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. The methyl group can be transfered to the nucleobase or to the ribose group of the nucleoside.”
- database_cross_reference “GOC:mah”

tRNA pseudouridine synthase activity `http://purl.obolibrary.org/obo/GO_0106029`

Added

tRNA pseudouridine synthase activity database_cross_reference “RHEA:42964”
tRNA pseudouridine synthase activity narrowMatch 60556
tRNA pseudouridine synthase activity narrowMatch 42964
tRNA pseudouridine synthase activity narrowMatch 57876
tRNA pseudouridine synthase activity database_cross_reference “RHEA:60556”
tRNA pseudouridine synthase activity database_cross_reference “RHEA:57876”

tRNA(Ser) (uridine(44)-2’-O-ribose)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0141101`

Removed

tRNA(Ser) (uridine(44)-2’-O-ribose)-methyltransferase activity label “tRNA(Ser) (uridine(44)-2’-O-)-methyltransferase activity”

Added

tRNA(Ser) (uridine(44)-2’-O-ribose)-methyltransferase activity has_exact_synonym “tRNA(Ser) (uridine(44)-2’-O-)-methyltransferase activity”
tRNA(Ser) (uridine(44)-2’-O-ribose)-methyltransferase activity label “tRNA(Ser) (uridine(44)-2’-O-ribose)-methyltransferase activity”

tRNA(Val) (adenine(37)-N6)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_7770054`

Added

tRNA(Val) (adenine(37)-N6)-methyltransferase activity database_cross_reference “EC:2.1.1.223”
tRNA(Val) (adenine(37)-N6)-methyltransferase activity has_obo_namespace “molecular_function”
tRNA(Val) (adenine(37)-N6)-methyltransferase activity exactMatch 43160
tRNA(Val) (adenine(37)-N6)-methyltransferase activity created by “dragon-ai-agent”
tRNA(Val) (adenine(37)-N6)-methyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31644”^^anyURI
tRNA(Val) (adenine(37)-N6)-methyltransferase activity database_cross_reference “RHEA:43160”
tRNA(Val) (adenine(37)-N6)-methyltransferase activity creation date “2026-02-28T05:25:40Z”
tRNA(Val) (adenine(37)-N6)-methyltransferase activity id “GO:7770054”
tRNA(Val) (adenine(37)-N6)-methyltransferase activity label “tRNA(Val) (adenine(37)-N6)-methyltransferase activity”
tRNA(Val) (adenine(37)-N6)-methyltransferase activity definition “Catalysis of the reaction: S-adenosyl-L-methionine + adenosine(37) in tRNA(Val) = S-adenosyl-L-homocysteine + N(6)-methyladenosine(37) in tRNA(Val) + H+.”
- database_cross_reference “RHEA:43160”
- database_cross_reference “PMID:19383770”
tRNA(Val) (adenine(37)-N6)-methyltransferase activity exactMatch 2.1.1.223
Class: tRNA(Val) (adenine(37)-N6)-methyltransferase activity
tRNA(Val) (adenine(37)-N6)-methyltransferase activity SubClassOf tRNA (adenine) methyltransferase activity
tRNA(Val) (adenine(37)-N6)-methyltransferase activity SubClassOf N-methyltransferase activity

tRNA-guanosine(34) queuine transglycosylase activity `http://purl.obolibrary.org/obo/GO_0008479`

Removed

tRNA-guanosine(34) queuine transglycosylase activity database_cross_reference “Reactome:R-HSA-6782443”
- label “QTRT1:QTRTD1 exchange guanine for queuosine at guanosine-34 of tRNA(Tyr)”

Added

tRNA-guanosine(34) queuine transglycosylase activity database_cross_reference “RHEA:78299”
tRNA-guanosine(34) queuine transglycosylase activity narrowMatch 78299
tRNA-guanosine(34) queuine transglycosylase activity narrowMatch 78303
tRNA-guanosine(34) queuine transglycosylase activity database_cross_reference “RHEA:78303”
tRNA-guanosine(34) queuine transglycosylase activity database_cross_reference “Reactome:R-HSA-6782443”
- label “QTRT1:QTRTD1 exchanges guanine for queuine at guanosine-34 of tRNA(Asn),tRNA(Asp),tRNA(His),tRNA(Tyr) yielding queuosine-34 tRNA(Asn),tRNA(Asp),tRNA(His),tRNA(Tyr)”

tRNA-specific adenosine deaminase activity `http://purl.obolibrary.org/obo/GO_0008251`

Removed

tRNA-specific adenosine deaminase activity definition “Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule.”
- database_cross_reference “GOC:mah”

Added

tRNA-specific adenosine deaminase activity definition “Catalysis of the reaction: adenosine + H2O = inosine + NH4+, in a tRNA molecule.”
- database_cross_reference “GOC:mah”

tRNA-specific adenosine-34 deaminase activity `http://purl.obolibrary.org/obo/GO_0052717`

Removed

tRNA-specific adenosine-34 deaminase activity definition “Catalysis of the reaction: adenosine-34 + H2O = inosine-34 + NH3, in a tRNA-Ala molecule.”
- database_cross_reference “PMID:17875641”
- database_cross_reference “RHEA:43168”

Added

tRNA-specific adenosine-34 deaminase activity definition “Catalysis of the reaction: adenosine34 in tRNA + H2O + H+ = inosine34 in tRNA + NH4+.”
- database_cross_reference “PMID:17875641”
- database_cross_reference “RHEA:43168”

tRNA-specific adenosine-37 deaminase activity `http://purl.obolibrary.org/obo/GO_0043829`

Removed

tRNA-specific adenosine-37 deaminase activity definition “Catalysis of the reaction: adenosine-37 + H2O = inosine-37 + NH3, in a tRNA-Ala molecule.”
- database_cross_reference “PMID:9707437”
- database_cross_reference “RHEA:50968”
- database_cross_reference “PMID:8915538”

Added

tRNA-specific adenosine-37 deaminase activity definition “Catalysis of the reaction: adenosine-37 + H2O = inosine-37 + NH4+, in a tRNA-Ala molecule.”
- database_cross_reference “PMID:9707437”
- database_cross_reference “RHEA:50968”
- database_cross_reference “PMID:8915538”

tRNA-uridine aminocarboxypropyltransferase activity `http://purl.obolibrary.org/obo/GO_0016432`

Added

taurine biosynthetic process `http://purl.obolibrary.org/obo/GO_0042412`

Added

taurine biosynthetic process narrowMatch PWY-7850
taurine biosynthetic process database_cross_reference “MetaCyc:PWY-8359”
taurine biosynthetic process database_cross_reference “MetaCyc:PWY-5331”
taurine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31281”^^anyURI
taurine biosynthetic process database_cross_reference “MetaCyc:PWY-7850”
taurine biosynthetic process narrowMatch PWY-5331
taurine biosynthetic process narrowMatch PWY-8359

taurine catabolic process `http://purl.obolibrary.org/obo/GO_0019529`

Added

taurine catabolic process narrowMatch PWY-1264
taurine catabolic process narrowMatch PWY-1263
taurine catabolic process database_cross_reference “MetaCyc:PWY-1264”
taurine catabolic process database_cross_reference “MetaCyc:PWY-1263”
taurine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
taurine catabolic process database_cross_reference “MetaCyc:PWY0-981”
taurine catabolic process narrowMatch TAURINEDEG-PWY
taurine catabolic process narrowMatch PWY0-981

taurine dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0050323`

Added

taurine dehydrogenase activity database_cross_reference “RHEA:81555”
taurine dehydrogenase activity narrowMatch 81555

taurine:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0050322`

Removed

taurine:2-oxoglutarate transaminase activity label “taurine-2-oxoglutarate transaminase activity”

Added

taurine:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
taurine:2-oxoglutarate transaminase activity label “taurine:2-oxoglutarate transaminase activity”
taurine:2-oxoglutarate transaminase activity has_exact_synonym “taurine-2-oxoglutarate transaminase activity”

taurine:pyruvate transaminase activity `http://purl.obolibrary.org/obo/GO_0031299`

Removed

taurine:pyruvate transaminase activity definition “Catalysis of the reaction: pyruvate + taurine = L-alanine + sulfoacetaldehyde.”
- database_cross_reference “PMID:11082195”
- database_cross_reference “RHEA:10420”
taurine:pyruvate transaminase activity label “taurine-pyruvate aminotransferase activity”

Added

taurine:pyruvate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
taurine:pyruvate transaminase activity label “taurine:pyruvate transaminase activity”
taurine:pyruvate transaminase activity definition “Catalysis of the reaction: taurine + pyruvate = sulfoacetaldehyde + L-alanine.”
- database_cross_reference “PMID:11082195”
- database_cross_reference “RHEA:10420”
taurine:pyruvate transaminase activity has_exact_synonym “taurine-pyruvate aminotransferase activity”

telomeric repeat DNA binding `http://purl.obolibrary.org/obo/GO_0042162`

Removed

telomeric repeat DNA binding label “telomeric DNA binding”
telomeric repeat DNA binding has_exact_synonym “telomere binding”
telomeric repeat DNA binding definition “Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end.”
- database_cross_reference “GOC:jl”
- database_cross_reference “SO:0000624”

Added

telomeric repeat DNA binding term tracker item “https://github.com/geneontology/go-ontology/issues/31610”^^anyURI
telomeric repeat DNA binding label “telomeric repeat DNA binding”
telomeric repeat DNA binding has_broad_synonym “telomere binding”
telomeric repeat DNA binding definition “Any molecular function by which a gene product interacts selectively and non-covalently with a telomeric DNA repeat sequence.”
- database_cross_reference “GOC:vw”
- database_cross_reference “SO:0000624”

tenascin complex `http://purl.obolibrary.org/obo/GO_0090733`

Added

tenascin complex SubClassOf extracellular protein-containing complex

terms_contributor `http://purl.obolibrary.org/obo/terms_contributor`

Added

AnnotationProperty: terms_contributor

terreate biosynthetic process `http://purl.obolibrary.org/obo/GO_0180067`

Added

terreate biosynthetic process id “GO:0180067”
terreate biosynthetic process creation date “2026-02-23T10:27:33Z”
terreate biosynthetic process label “terreate biosynthetic process”
terreate biosynthetic process has_obo_namespace “biological_process”
terreate biosynthetic process has_related_synonym “terreic acid biosynthetic process”
terreate biosynthetic process created by “PomBase:vw”
terreate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of terreate, a fungal metabolite with ecological, antimicrobial, antiproliferative, and antioxidative activities.”
- database_cross_reference “PMID:25265334”
terreate biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31114”^^anyURI
Class: terreate biosynthetic process
terreate biosynthetic process SubClassOf quinone biosynthetic process
terreate biosynthetic process SubClassOf tertiary alcohol biosynthetic process
terreate biosynthetic process SubClassOf ether biosynthetic process
terreate biosynthetic process SubClassOf olefinic compound biosynthetic process
terreate biosynthetic process SubClassOf epoxide metabolic process

testosterone dehydrogenase (NADP+) activity `http://purl.obolibrary.org/obo/GO_0047045`

Added

testosterone dehydrogenase (NADP+) activity database_cross_reference “Reactome:R-HSA-193064”
- label “HSD17B3-like proteins reducde ANDST to TEST”

tetrahydrobiopterin binding `http://purl.obolibrary.org/obo/GO_0034617`

Added

tetrahydrobiopterin binding database_cross_reference “Reactome:R-HSA-1497796”
- label “BH2 binding can lead to eNOS uncoupling”

tetrahydrodipicolinate N-acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0047200`

Removed

tetrahydrodipicolinate N-acetyltransferase activity definition “Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O = L-2-acetamido-6-oxopimelate + CoA.”
- database_cross_reference “EC:2.3.1.89”
- database_cross_reference “RHEA:13085”

Added

tetrahydrodipicolinate N-acetyltransferase activity definition “Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O = L-2-acetamido-6-oxopimelate + CoA.”
- database_cross_reference “RHEA:13085”

tetrahydrofolate interconversion `http://purl.obolibrary.org/obo/GO_0035999`

Added

tetrahydrofolate interconversion term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
tetrahydrofolate interconversion narrowMatch PWY-2201

tetraterpenoid biosynthetic process `http://purl.obolibrary.org/obo/GO_0016109`

Removed

tetraterpenoid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of tetraterpenoid compounds, terpenoids with eight isoprene units.”
- database_cross_reference “GOC:go_curators”

Added

tetraterpenoid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of tetraterpenoid compounds, terpenoids with eight isoprene units.”
- database_cross_reference “GOC:curators”

tetraterpenoid catabolic process `http://purl.obolibrary.org/obo/GO_0016110`

Removed

tetraterpenoid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of tetraterpenoid compounds, terpenoids with eight isoprene units.”
- database_cross_reference “GOC:go_curators”

Added

tetraterpenoid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of tetraterpenoid compounds, terpenoids with eight isoprene units.”
- database_cross_reference “GOC:curators”

thiamine biosynthetic process `http://purl.obolibrary.org/obo/GO_0009228`

Removed

thiamine biosynthetic process database_cross_reference “MetaCyc:THISYN-PWY”

Added

thiamine biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI

thiocyanate catabolic process `http://purl.obolibrary.org/obo/GO_0046265`

Removed

thiocyanate catabolic process SubClassOf small molecule catabolic process
thiocyanate catabolic process SubClassOf xenobiotic catabolic process

Added

thiocyanate catabolic process database_cross_reference “MetaCyc:P581-PWY”
thiocyanate catabolic process narrowMatch PWY-743
thiocyanate catabolic process database_cross_reference “MetaCyc:PWY-743”
thiocyanate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
thiocyanate catabolic process narrowMatch P581-PWY

thiocyanate metabolic process `http://purl.obolibrary.org/obo/GO_0018969`

Removed

thiocyanate metabolic process database_cross_reference “MetaCyc:P581-PWY”
thiocyanate metabolic process SubClassOf xenobiotic metabolic process
thiocyanate metabolic process SubClassOf organic acid metabolic process

Added

thiocyanate metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI

thiocyanate peroxidase activity `http://purl.obolibrary.org/obo/GO_0036393`

Removed

thiocyanate peroxidase activity definition “Catalysis of the reaction: thiocyanate (SCN-) + hydrogen peroxide (H2O2) = hypothiocyanite (OSCN-) + 2 H2O. Catalyzes the hydrogen peroxide oxidation of thiocyanate.”
- database_cross_reference “GOC:pm”
- database_cross_reference “PMID:12626341”

Added

thiocyanate peroxidase activity database_cross_reference “RHEA:69416”
thiocyanate peroxidase activity definition “Catalysis of the reaction: thiocyanate + H2O2 + H+ = hypothiocyanous acid + H2O.”
- database_cross_reference “GOC:pm”
- database_cross_reference “PMID:12626341”
- database_cross_reference “RHEA:69416”

thiomorpholine-carboxylate dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0047127`

Removed

thiomorpholine-carboxylate dehydrogenase activity database_cross_reference “Reactome:R-HSA-5693347”
- label “CRYM reduces P2C to PPCA”

thioredoxin peroxidase activity `http://purl.obolibrary.org/obo/GO_0008379`

Removed

thioredoxin peroxidase activity definition “Catalysis of the reaction: [thioredoxin]-dithiol + hydrogen peroxide = [thioredoxin]-disulfide + H2O.”
- database_cross_reference “RHEA:63528”

Added

thioredoxin peroxidase activity definition “Catalysis of the reaction: [thioredoxin]-dithiol + H2O2 = [thioredoxin]-disulfide + H2O.”
- database_cross_reference “RHEA:63528”

thioredoxin-dependent peroxiredoxin activity `http://purl.obolibrary.org/obo/GO_0140824`

Added

thioredoxin-dependent peroxiredoxin activity database_cross_reference “RHEA:63844”
thioredoxin-dependent peroxiredoxin activity narrowMatch 63844
thioredoxin-dependent peroxiredoxin activity narrowMatch 63840
thioredoxin-dependent peroxiredoxin activity database_cross_reference “RHEA:63840”

thiosulfate oxidation `http://purl.obolibrary.org/obo/GO_0019416`

Removed

thiosulfate oxidation label “polythionate oxidation”

Added

thiosulfate oxidation database_cross_reference “MetaCyc:PWY-6677”
thiosulfate oxidation database_cross_reference “MetaCyc:PWY-5303”
thiosulfate oxidation narrowMatch PWY-5296
thiosulfate oxidation term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
thiosulfate oxidation narrowMatch THIOSULFOX-PWY
thiosulfate oxidation database_cross_reference “MetaCyc:PWY-5296”
thiosulfate oxidation narrowMatch PWY-5303
thiosulfate oxidation narrowMatch PWY-6677
thiosulfate oxidation has_exact_synonym “polythionate oxidation”
thiosulfate oxidation label “thiosulfate oxidation”

threonine deaminase activity `http://purl.obolibrary.org/obo/GO_0004794`

Added

threonine deaminase activity database_cross_reference “Reactome:R-HSA-9014627”
- label “SDS dimers:PXLP convert L-Thr to 2OBUTA”

thrombospondin complex `http://purl.obolibrary.org/obo/GO_1990341`

Removed

thrombospondin complex SubClassOf protein-containing complex

Added

thrombospondin complex SubClassOf extracellular protein-containing complex

thymidine biosynthetic process `http://purl.obolibrary.org/obo/GO_0046105`

Removed

thymidine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA.”
- database_cross_reference “GOC:go_curators”

Added

thymidine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA.”
- database_cross_reference “GOC:curators”

thymidine catabolic process `http://purl.obolibrary.org/obo/GO_0006214`

Removed

thymidine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA.”
- database_cross_reference “GOC:go_curators”

Added

thymidine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA.”
- database_cross_reference “GOC:curators”

thymidine metabolic process `http://purl.obolibrary.org/obo/GO_0046104`

Removed

thymidine metabolic process definition “The chemical reactions and pathways involving thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA.”
- database_cross_reference “GOC:go_curators”

Added

thymidine metabolic process definition “The chemical reactions and pathways involving thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA.”
- database_cross_reference “GOC:curators”

thymine biosynthetic process `http://purl.obolibrary.org/obo/GO_0046106`

Removed

thymine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.”
- database_cross_reference “GOC:go_curators”

Added

thymine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.”
- database_cross_reference “GOC:curators”

thymine catabolic process `http://purl.obolibrary.org/obo/GO_0006210`

Removed

thymine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.”
- database_cross_reference “GOC:go_curators”

Added

thymine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.”
- database_cross_reference “GOC:curators”

thymine metabolic process `http://purl.obolibrary.org/obo/GO_0019859`

Removed

thymine metabolic process definition “The chemical reactions and pathways involving thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.”
- database_cross_reference “GOC:go_curators”

Added

thymine metabolic process definition “The chemical reactions and pathways involving thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.”
- database_cross_reference “GOC:curators”

thyroid-hormone:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0033852`

Removed

thyroid-hormone:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 2-oxoglutarate + 3,5,3’-triiodo-L-thyronine = 3,5,3’-triiodothyropyruvate + L-glutamate.”
- database_cross_reference “EC:2.6.1.26”
- database_cross_reference “RHEA:19133”
thyroid-hormone:2-oxoglutarate transaminase activity label “thyroid-hormone transaminase activity”

Added

thyroid-hormone:2-oxoglutarate transaminase activity definition “Catalysis of the reaction: 3,3’,5-triiodo-L-thyronine + 2-oxoglutarate = 3,5,3’-triiodothyropyruvate + L-glutamate.”
- database_cross_reference “RHEA:19133”
thyroid-hormone:2-oxoglutarate transaminase activity has_broad_synonym “thyroid-hormone transaminase activity”
thyroid-hormone:2-oxoglutarate transaminase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31140”^^anyURI
thyroid-hormone:2-oxoglutarate transaminase activity label “thyroid-hormone:2-oxoglutarate transaminase activity”

thyroid-stimulating hormone receptor activity `http://purl.obolibrary.org/obo/GO_0004996`

Added

thyroid-stimulating hormone receptor activity database_cross_reference “Reactome:R-HSA-391375”
- label “TSHR binds TSH/Thyrostimulin”

thyroxine 5’-deiodinase activity `http://purl.obolibrary.org/obo/GO_0004800`

Removed

thyroxine 5’-deiodinase activity database_cross_reference “Reactome:R-HSA-350869”
- label “Thyroxine is deiodinated to reverse triiodothyronine (RT3)”

thyroxine 5-deiodinase activity `http://purl.obolibrary.org/obo/GO_0033798`

Added

thyroxine 5-deiodinase activity database_cross_reference “Reactome:R-HSA-350869”
- label “Thyroxine is deiodinated to reverse triiodothyronine (RT3)”

torso signaling pathway `http://purl.obolibrary.org/obo/GO_0008293`

Removed

torso signaling pathway definition “The series of molecular signals initiated by an extracellular ligand binding to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:8343949”

Added

torso signaling pathway definition “The series of molecular signals initiated by an extracellular ligand binding to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:8343949”

toxin biosynthetic process `http://purl.obolibrary.org/obo/GO_0009403`

Removed

toxin biosynthetic process definition “The chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.”
- database_cross_reference “GOC:go_curators”

Added

toxin biosynthetic process definition “The chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.”
- database_cross_reference “GOC:curators”

toxin catabolic process `http://purl.obolibrary.org/obo/GO_0009407`

Removed

toxin catabolic process definition “The chemical reactions and pathways resulting in the breakdown of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.”
- database_cross_reference “GOC:go_curators”

Added

toxin catabolic process definition “The chemical reactions and pathways resulting in the breakdown of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.”
- database_cross_reference “GOC:curators”

trans-2-enoyl-CoA reductase (NADH) activity `http://purl.obolibrary.org/obo/GO_0050343`

Added

trans-2-enoyl-CoA reductase (NADH) activity narrowMatch 63232
trans-2-enoyl-CoA reductase (NADH) activity narrowMatch 46076
trans-2-enoyl-CoA reductase (NADH) activity database_cross_reference “RHEA:46072”
trans-2-enoyl-CoA reductase (NADH) activity database_cross_reference “RHEA:46080”
trans-2-enoyl-CoA reductase (NADH) activity narrowMatch 46080
trans-2-enoyl-CoA reductase (NADH) activity database_cross_reference “RHEA:63232”
trans-2-enoyl-CoA reductase (NADH) activity database_cross_reference “RHEA:46076”
trans-2-enoyl-CoA reductase (NADH) activity narrowMatch 46072

trans-2-enoyl-CoA reductase (NADPH) activity `http://purl.obolibrary.org/obo/GO_0019166`

Added

trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39263
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39515
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39239”
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39479”
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39563”
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39355”
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39467”
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39503
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39391”
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39319”
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39275”
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39403
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39251
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39491”
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39179”
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39427
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39307
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39331
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:35367”
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39347”
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39443”
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39539
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:35363”
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39347
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39275
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39503”
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39415
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39563
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39551”
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 35367
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39319
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 35363
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 35351
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39191
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 36143
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39527”
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39379
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39331”
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39251”
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39415”
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39203
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39391
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39467
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39455
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39515”
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39203”
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39427”
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39215”
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39539”
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39403”
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39443
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39191”
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39551
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39179
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39215
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39367
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39263”
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39367”
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39527
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39379”
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39455”
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39307”
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39491
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:35351”
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39355
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39227
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:36143”
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39239
trans-2-enoyl-CoA reductase (NADPH) activity narrowMatch 39479
trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference “RHEA:39227”

trans-4-hydroxy-L-proline catabolic process `http://purl.obolibrary.org/obo/GO_0019470`

Removed

trans-4-hydroxy-L-proline catabolic process definition “The chemical reactions and pathways resulting in the breakdown of trans-4-hydroxy-L-proline, C5H9NO3, a derivative of the amino acid proline.”
- database_cross_reference “GOC:ai”

Added

trans-4-hydroxy-L-proline catabolic process definition “The chemical reactions and pathways resulting in the breakdown of trans-4-hydroxy-L-proline.”
- database_cross_reference “GOC:curators”
trans-4-hydroxy-L-proline catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31405”^^anyURI

trans-Golgi network to recycling endosome transport `http://purl.obolibrary.org/obo/GO_0044795`

Added

trans-Golgi network to recycling endosome transport SubClassOf intercellular transport

transcription coregulator activity `http://purl.obolibrary.org/obo/GO_0003712`

Removed

transcription coregulator activity SubClassOf protein-macromolecule adaptor activity

Added

transcription coregulator activity term tracker item “https://github.com/geneontology/go-ontology/issues/31471”^^anyURI
transcription coregulator activity database_cross_reference “Reactome:R-HSA-5340251”
- label “NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2”

transcription corepressor activity `http://purl.obolibrary.org/obo/GO_0003714`

Added

transcription corepressor activity database_cross_reference “Reactome:R-HSA-400183”
- label “PPARA:RXRA binds Corepressors of PPARA”

transferase activity `http://purl.obolibrary.org/obo/GO_0016740`

Added

transferase activity database_cross_reference “Reactome:R-HSA-5333607”
- label “GSSeH combines with bGalNAc derivative to form GSSebGalNac”

transferase activity, transferring phosphorus-containing groups `http://purl.obolibrary.org/obo/GO_0016772`

Added

transferase activity, transferring phosphorus-containing groups database_cross_reference “Reactome:R-HSA-9932322”
- label “BcsG transfers pEtN from PE onto cellulose”

transforming growth factor beta complex `http://purl.obolibrary.org/obo/GO_0099126`

Removed

transforming growth factor beta complex SubClassOf part of some extracellular region
transforming growth factor beta complex SubClassOf protein-containing complex

Added

transforming growth factor beta complex SubClassOf extracellular protein-containing complex

translation `http://purl.obolibrary.org/obo/GO_0006412`

Removed

translation definition “The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.”
- database_cross_reference “GOC:go_curators”

Added

translation definition “The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.”
- database_cross_reference “GOC:curators”

translocation of peptides or proteins into host `http://purl.obolibrary.org/obo/GO_0042000`

Added

translocation of peptides or proteins into host database_cross_reference “Reactome:R-HSA-9760173”
- label “Secretion of toxins”

transmembrane phosphate ion transport from cytosol to vacuole `http://purl.obolibrary.org/obo/GO_1905011`

Added

transmembrane phosphate ion transport from cytosol to vacuole SubClassOf intercellular transport

transmembrane protein transporter activity `http://purl.obolibrary.org/obo/GO_0008320`

Removed

transmembrane protein transporter activity label “protein transmembrane transporter activity”

Added

transmembrane protein transporter activity has_exact_synonym “protein transmembrane transporter activity”
transmembrane protein transporter activity label “transmembrane protein transporter activity”
transmembrane protein transporter activity database_cross_reference “Reactome:R-HSA-9760705”
- label “GspD2:GspC2:GspS2 transports LT from periplasmic to extracellular space”

transmembrane signaling receptor activity `http://purl.obolibrary.org/obo/GO_0004888`

Removed

transmembrane signaling receptor activity definition “Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “Wikipedia:Transmembrane_receptor”

Added

transmembrane signaling receptor activity definition “Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.”
- database_cross_reference “GOC:curators”
- database_cross_reference “Wikipedia:Transmembrane_receptor”

transmembrane transport from lysosomal lumen to cytosol `http://purl.obolibrary.org/obo/GO_0170063`

Added

transmembrane transport from lysosomal lumen to cytosol has_exact_synonym “export from lysosome lumen to cytosol”
transmembrane transport from lysosomal lumen to cytosol SubClassOf intercellular transport

transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0022857`

Added

transmembrane transporter activity database_cross_reference “Reactome:R-HSA-561041”
- label “OAT1,2,3 transport organic anions with antiport of dicarboxylic acids”
transmembrane transporter activity database_cross_reference “Reactome:R-HSA-2161500”
- label “abacavir [extracellular] => abacavir [cytosol]”
transmembrane transporter activity database_cross_reference “Reactome:R-HSA-549129”
- label “OCT1 transports organic cations into hepatic cells”
transmembrane transporter activity database_cross_reference “Reactome:R-HSA-561054”
- label “OCT2 mediates tubular secretion of organic cations in the kidney”
transmembrane transporter activity database_cross_reference “Reactome:R-HSA-549322”
- label “OCT1 transports organic cations out of hepatic cells”
transmembrane transporter activity database_cross_reference “Reactome:R-HSA-549279”
- label “OCT2 mediates tubular uptake of organic cations in the kidney”
transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9794830”
- label “SLC22A8 transports Cipro into renal cell”
transmembrane transporter activity database_cross_reference “Reactome:R-HSA-8954513”
- label “NAASP translocates from mitochondrial matrix to cytosol”
transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9795207”
- label “SLC22A1 transports Cipro into hepatic cell”
transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9794270”
- label “SLCO1A2 transports Cipro(1+) into the cytosol”
transmembrane transporter activity database_cross_reference “Reactome:R-HSA-549304”
- label “OCT3 mediates renal clearance of organic cations”
transmembrane transporter activity database_cross_reference “Reactome:R-HSA-561072”
- label “OCT3 mediates renal uptake of organic cations”
transmembrane transporter activity database_cross_reference “Reactome:R-HSA-2142859”
- label “Growing HA is extruded from the cell by ABCC5”
transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9794523”
- label “SLC22A1 transports Cipro into renal cell”

transsulfuration `http://purl.obolibrary.org/obo/GO_0019346`

Removed

transsulfuration SubClassOf obsolete L-cysteine metabolic process

Added

transsulfuration SubClassOf L-amino acid metabolic process
transsulfuration SubClassOf proteinogenic amino acid metabolic process

trehalose biosynthetic process `http://purl.obolibrary.org/obo/GO_0005992`

Added

trehalose biosynthetic process narrowMatch PWY-2622
trehalose biosynthetic process database_cross_reference “MetaCyc:PWY-5983”
trehalose biosynthetic process narrowMatch PWY-5985
trehalose biosynthetic process database_cross_reference “MetaCyc:PWY-5985”
trehalose biosynthetic process narrowMatch PWY-5983
trehalose biosynthetic process database_cross_reference “MetaCyc:PWY-2622”
trehalose biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI

trehalose synthase activity `http://purl.obolibrary.org/obo/GO_0102986`

Removed

trehalose synthase activity relatedMatch PWY-5985
trehalose synthase activity comment “Note that this term has a MetaCyc pathway reference as the pathway only has a single step.”
trehalose synthase activity relatedMatch PWY-2622
trehalose synthase activity relatedMatch PWY-5983

Added

trehalose synthase activity narrowMatch 25408
trehalose synthase activity database_cross_reference “RHEA:25408”
trehalose synthase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI

triacylglycerol lipase activity `http://purl.obolibrary.org/obo/GO_0004806`

Added

triacylglycerol lipase activity database_cross_reference “RHEA:40475”
triacylglycerol lipase activity database_cross_reference “RHEA:48024”
triacylglycerol lipase activity narrowMatch 38495
triacylglycerol lipase activity narrowMatch 47864
triacylglycerol lipase activity database_cross_reference “RHEA:48028”
triacylglycerol lipase activity narrowMatch 48028
triacylglycerol lipase activity narrowMatch 59020
triacylglycerol lipase activity database_cross_reference “RHEA:47864”
triacylglycerol lipase activity narrowMatch 59024
triacylglycerol lipase activity database_cross_reference “RHEA:59020”
triacylglycerol lipase activity narrowMatch 40475
triacylglycerol lipase activity database_cross_reference “RHEA:59024”
triacylglycerol lipase activity database_cross_reference “RHEA:35667”
triacylglycerol lipase activity database_cross_reference “RHEA:38495”
triacylglycerol lipase activity database_cross_reference “RHEA:38575”
triacylglycerol lipase activity narrowMatch 38575
triacylglycerol lipase activity narrowMatch 48024
triacylglycerol lipase activity narrowMatch 35667

triglyceride-sterol O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0047197`

Added

triose-phosphate isomerase activity `http://purl.obolibrary.org/obo/GO_0004807`

Removed

triose-phosphate isomerase activity database_cross_reference “Reactome:R-HSA-70481”
- label “TPI1 isomerizes GA3P to DHAP”
triose-phosphate isomerase activity database_cross_reference “Reactome:R-HSA-70454”
- label “dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate”

Added

triose-phosphate isomerase activity database_cross_reference “Reactome:R-HSA-70481”
- label “TPI1 dimer isomerizes GA3P to DHAP”
triose-phosphate isomerase activity database_cross_reference “Reactome:R-HSA-70454”
- label “TPI1 dimer isomerizes DHAP to GA3P”

triterpenoid biosynthetic process `http://purl.obolibrary.org/obo/GO_0016104`

Removed

triterpenoid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of triterpenoid compounds, terpenoids with six isoprene units.”
- database_cross_reference “GOC:go_curators”

Added

triterpenoid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of triterpenoid compounds, terpenoids with six isoprene units.”
- database_cross_reference “GOC:curators”

triterpenoid catabolic process `http://purl.obolibrary.org/obo/GO_0016105`

Removed

triterpenoid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of triterpenoid compounds, terpenoids with six isoprene units.”
- database_cross_reference “GOC:go_curators”

Added

triterpenoid catabolic process definition “The chemical reactions and pathways resulting in the breakdown of triterpenoid compounds, terpenoids with six isoprene units.”
- database_cross_reference “GOC:curators”

tryparedoxin peroxidase activity `http://purl.obolibrary.org/obo/GO_0033196`

Removed

tryparedoxin peroxidase activity definition “Catalysis of the reaction: tryparedoxin + hydrogen peroxide = tryparedoxin disulfide + H2O.”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:32388269”

Added

tryparedoxin peroxidase activity definition “Catalysis of the reaction: tryparedoxin + H2O2 = tryparedoxin disulfide + H2O.”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:32388269”

tryptophan 2’-dioxygenase activity `http://purl.obolibrary.org/obo/GO_0050360`

Removed

tryptophan 2’-dioxygenase activity definition “Catalysis of the reaction: L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH3.”
- database_cross_reference “MetaCyc:TRYPTOPHAN-2-DIOXYGENASE-RXN”
- database_cross_reference “EC:1.13.99.3”

Added

tryptophan 2’-dioxygenase activity definition “Catalysis of the reaction: L-tryptophan + O2 + H+ = 3-indoleglycolaldehyde + NH4+ + CO2.”
- database_cross_reference “RHEA:22620”

tryptophan 2-C-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0030772`

Removed

tryptophan 2-C-methyltransferase activity definition “Catalysis of the reaction: S-adenosyl-L-methionine(1+) + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan + H+.”
- database_cross_reference “EC:2.1.1.106”
- database_cross_reference “RHEA:17321”

Added

tryptophan 2-C-methyltransferase activity definition “Catalysis of the reaction: L-tryptophan + S-adenosyl-L-methionine = 2-methyl-L-tryptophan + S-adenosyl-L-homocysteine + H+.”
- database_cross_reference “RHEA:17321”

tryptophan-independent indoleacetic acid biosynthetic process `http://purl.obolibrary.org/obo/GO_0009849`

Removed

tryptophan-independent indoleacetic acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of indoleacetic acid, independent of tryptophan.”
- database_cross_reference “GOC:lr”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:10375566”
- database_cross_reference “GOC:lm”

Added

tryptophan-independent indoleacetic acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of indoleacetic acid, independent of tryptophan.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:lr”
- database_cross_reference “PMID:10375566”
- database_cross_reference “GOC:lm”

tryptophanase activity `http://purl.obolibrary.org/obo/GO_0009034`

Removed

tryptophanase activity relatedMatch TRYPDEG-PWY
tryptophanase activity comment “Note that this term has a MetaCyc pathway reference as the pathway only has a single step.”

Added

tryptophanase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31587”^^anyURI

type IV pilus-dependent motility `http://purl.obolibrary.org/obo/GO_0043107`

Removed

type IV pilus-dependent motility definition “Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:12704238”

Added

type IV pilus-dependent motility definition “Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:12704238”

tyramine N-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0030738`

Removed

tyramine N-methyltransferase activity definition “Catalysis of the reaction: S-adenosyl-L-methionine + tyramine = N-methyltyramine + S-adenosyl-L-homocysteine + H+.”
- database_cross_reference “RHEA:14865”
- database_cross_reference “EC:2.1.1.27”

Added

tyramine N-methyltransferase activity definition “Catalysis of the reaction: S-adenosyl-L-methionine + tyramine = N-methyltyramine + S-adenosyl-L-homocysteine + H+.”
- database_cross_reference “RHEA:14865”

tyramine loading into synaptic vesicle `http://purl.obolibrary.org/obo/GO_0160311`

Added

tyramine loading into synaptic vesicle id “GO:0160311”
tyramine loading into synaptic vesicle created by “rynl”
tyramine loading into synaptic vesicle term tracker item “https://github.com/geneontology/go-ontology/issues/31143”^^anyURI
tyramine loading into synaptic vesicle label “tyramine loading into synaptic vesicle”
tyramine loading into synaptic vesicle has_obo_namespace “biological_process”
tyramine loading into synaptic vesicle creation date “2025-12-02T23:16:14Z”
tyramine loading into synaptic vesicle definition “The active transport of tyramine neurotransmitters into a synaptic vesicle.”
- database_cross_reference “PMID:9870940”
- database_cross_reference “PMID:15849736”
Class: tyramine loading into synaptic vesicle
tyramine loading into synaptic vesicle SubClassOf tyramine transport
tyramine loading into synaptic vesicle SubClassOf aminergic neurotransmitter loading into synaptic vesicle

tyrosine metabolic process `http://purl.obolibrary.org/obo/GO_0006570`

Removed

tyrosine metabolic process definition “The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.”
- database_cross_reference “GOC:go_curators”

Added

tyrosine metabolic process definition “The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.”
- database_cross_reference “GOC:curators”

ubiquitin binding `http://purl.obolibrary.org/obo/GO_0043130`

Removed

ubiquitin binding database_cross_reference “Reactome:R-HSA-1169404”
- label “Transfer of ISG15 from E1 to E2 (UBCH8)”

ubiquitin ligase complex scaffold activity `http://purl.obolibrary.org/obo/GO_0160072`

Removed

ubiquitin ligase complex scaffold activity SubClassOf protein-macromolecule adaptor activity

Added

ubiquitin ligase complex scaffold activity term tracker item “https://github.com/geneontology/go-ontology/issues/31499”^^anyURI
ubiquitin ligase complex scaffold activity SubClassOf protein complex scaffold activity

ubiquitin protein ligase activity `http://purl.obolibrary.org/obo/GO_0061630`

Added

ubiquitin protein ligase activity database_cross_reference “Reactome:R-HSA-9931298”
- label “Ubiquitination of CD274 by ERAD complex”
ubiquitin protein ligase activity database_cross_reference “Reactome:R-HSA-9946390”
- label “NS1 dimer is ubiquitinated”
ubiquitin protein ligase activity database_cross_reference “Reactome:R-HSA-9945766”
- label “NS3 is ubiquitinated”
ubiquitin protein ligase activity database_cross_reference “Reactome:R-HSA-9932510”
- label “BTRC:CUL1:SKP1:RBX1 (SCF-beta-TrCP1) ubiquitinylates phosphorylated PER1,2,3”
ubiquitin protein ligase activity database_cross_reference “Reactome:R-HSA-9948362”
- label “LTN1 K48 polyubiquitinates the nascent peptide in NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide”
ubiquitin protein ligase activity database_cross_reference “Reactome:R-HSA-9929490”
- label “CD274 ubiquitination by SPOP:CUL3:RBX1 complex”
ubiquitin protein ligase activity database_cross_reference “Reactome:R-HSA-9931430”
- label “MIB2-mediated K63-ubiquitination of CD274”
ubiquitin protein ligase activity database_cross_reference “Reactome:R-HSA-9954737”
- label “RCHY1 K48 polyubiquitinates alanine-tailed nascent peptide”
ubiquitin protein ligase activity database_cross_reference “Reactome:R-HSA-9932512”
- label “FBXL3:CUL1:SKP1:RBX1 ubiquitinylates phosphorylated CRY1,2”

ubiquitin-dependent protein catabolic process `http://purl.obolibrary.org/obo/GO_0006511`

Removed

ubiquitin-dependent protein catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.”
- database_cross_reference “GOC:go_curators”

Added

ubiquitin-dependent protein catabolic process definition “The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.”
- database_cross_reference “GOC:curators”

ubiquitin-protein transferase activity `http://purl.obolibrary.org/obo/GO_0004842`

Removed

ubiquitin-protein transferase activity database_cross_reference “Reactome:R-HSA-69598”
- label “Ubiquitination of phosphorylated Cdc25A”
ubiquitin-protein transferase activity database_cross_reference “Reactome:R-HSA-1169397”
- label “Activation of ISG15 by UBA7 E1 ligase”
ubiquitin-protein transferase activity database_cross_reference “Reactome:R-HSA-1169394”
- label “ISGylation of IRF3”
ubiquitin-protein transferase activity database_cross_reference “Reactome:R-HSA-400267”
- label “BTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteins”
ubiquitin-protein transferase activity database_cross_reference “Reactome:R-HSA-9833973”
- label “ISGylation of PKR”
ubiquitin-protein transferase activity database_cross_reference “Reactome:R-HSA-1169406”
- label “ISGylation of host proteins”
ubiquitin-protein transferase activity database_cross_reference “Reactome:R-HSA-1169395”
- label “ISGylation of viral protein NS1”
ubiquitin-protein transferase activity database_cross_reference “Reactome:R-HSA-1169402”
- label “ISGylation of E2 conjugating enzymes”
ubiquitin-protein transferase activity database_cross_reference “Reactome:R-HSA-1169405”
- label “ISGylation of protein phosphatase 1 beta (PP2CB)”
ubiquitin-protein transferase activity database_cross_reference “Reactome:R-HSA-1169398”
- label “ISGylation of host protein filamin B”

Added

ubiquitin-protein transferase activity database_cross_reference “Reactome:R-HSA-9970191”
- label “RBBP6 activates CPSF complex”
ubiquitin-protein transferase activity database_cross_reference “Reactome:R-HSA-9766227”
- label “MDM2 mediates CDH1 ubiquitination”
ubiquitin-protein transferase activity database_cross_reference “Reactome:R-HSA-69598”
- label “Ubiquitination of phosphorylated CDC25A”
ubiquitin-protein transferase activity database_cross_reference “Reactome:R-HSA-9955146”
- label “S.flexneri ipaH9.8 ubiquitinates GBPs”
ubiquitin-protein transferase activity database_cross_reference “Reactome:R-HSA-9934753”
- label “CBLL1 ubiquitinates CDH1”
ubiquitin-protein transferase activity database_cross_reference “Reactome:R-HSA-9954721”
- label “NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 K48 polyubiquitinates alanine-tailed nascent peptide”
ubiquitin-protein transferase activity database_cross_reference “Reactome:R-HSA-9948301”
- label “ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit”
ubiquitin-protein transferase activity database_cross_reference “Reactome:R-HSA-9929350”
- label “Ubiquitination of CD274 by BTRC-SCF E3-ligase complex”

unfolded protein holdase activity `http://purl.obolibrary.org/obo/GO_0140309`

Removed

unfolded protein holdase activity has_broad_synonym “holdase”
unfolded protein holdase activity label “unfolded protein carrier activity”
unfolded protein holdase activity definition “A protein carrier activity that binds to a protein in an unfolded state and escorts it between two different cellular components. The unfolded protein carrier prevents aggregation of the target protein.”
- database_cross_reference “PMID:39488384”

Added

unfolded protein holdase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31601”^^anyURI
unfolded protein holdase activity has_exact_synonym “holdase”
unfolded protein holdase activity definition “A protein carrier activity that binds to a protein in an unfolded state and escorts it to an acceptor molecule or to a specific location. The unfolded protein carrier prevents aggregation of the target protein while it’s being delivers to its final destination.”
- database_cross_reference “PMID:39488384”
unfolded protein holdase activity label “unfolded protein holdase activity”
unfolded protein holdase activity has_exact_synonym “unfolded protein carrier activity”
unfolded protein holdase activity comment “Note that an holdase binds an unfolded protein and keeps it unfolded, unlike a protein folding chaperone, which binds an unfolded protein to fold it.”

uracil biosynthetic process `http://purl.obolibrary.org/obo/GO_0046107`

Removed

uracil biosynthetic process definition “The chemical reactions and pathways resulting in the formation of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA.”
- database_cross_reference “GOC:go_curators”

Added

uracil biosynthetic process definition “The chemical reactions and pathways resulting in the formation of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA.”
- database_cross_reference “GOC:curators”

uracil catabolic process `http://purl.obolibrary.org/obo/GO_0006212`

Removed

uracil catabolic process definition “The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA.”
- database_cross_reference “GOC:go_curators”

Added

uracil catabolic process definition “The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA.”
- database_cross_reference “GOC:curators”

uracil metabolic process `http://purl.obolibrary.org/obo/GO_0019860`

Removed

uracil metabolic process definition “The chemical reactions and pathways involving uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA.”
- database_cross_reference “GOC:go_curators”

Added

uracil metabolic process definition “The chemical reactions and pathways involving uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA.”
- database_cross_reference “GOC:curators”

uracil transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015210`

Removed

uracil transmembrane transporter activity definition “Enables the transfer of uracil, 2,4-dioxopyrimidine, from one side of a membrane to the other.”
- database_cross_reference “GOC:go_curators”

Added

uracil transmembrane transporter activity definition “Enables the transfer of uracil, 2,4-dioxopyrimidine, from one side of a membrane to the other.”
- database_cross_reference “GOC:curators”

uracil transport `http://purl.obolibrary.org/obo/GO_0015857`

Removed

uracil transport definition “The directed movement of uracil, 2,4-dioxopyrimidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:go_curators”

Added

uracil transport definition “The directed movement of uracil, 2,4-dioxopyrimidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:curators”

urate oxidase activity `http://purl.obolibrary.org/obo/GO_0004846`

Removed

urate oxidase activity definition “Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + hydrogen peroxide.”
- database_cross_reference “EC:1.7.3.3”

Added

urate oxidase activity definition “Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + H2O2.”
- database_cross_reference “EC:1.7.3.3”

urease activity `http://purl.obolibrary.org/obo/GO_0009039`

Removed

urease activity definition “Catalysis of the reaction: urea + H2O = CO2 + 2 NH3.”
- database_cross_reference “RHEA:20557”
- database_cross_reference “EC:3.5.1.5”

Added

urease activity definition “Catalysis of the reaction: urea + 2 H2O + H+ = hydrogencarbonate + 2 NH4+.”
- database_cross_reference “RHEA:20557”

ureidoglycine aminohydrolase activity `http://purl.obolibrary.org/obo/GO_0071522`

Removed

ureidoglycine aminohydrolase activity definition “Catalysis of the reaction: ureidoglycine + H2O = S-ureidoglycolate + NH3.”
- database_cross_reference “PMID:20038185”
- database_cross_reference “MetaCyc:URUR-RXN”
- database_cross_reference “PMID:19935661”

Added

ureidoglycine aminohydrolase activity definition “Catalysis of the reaction: (S)-2-ureidoglycine + H2O = (S)-ureidoglycolate + NH4+.”
- database_cross_reference “PMID:20038185”
- database_cross_reference “RHEA:25241”
- database_cross_reference “PMID:19935661”

ureteric bud development `http://purl.obolibrary.org/obo/GO_0001657`

Removed

ureteric bud development definition “The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.”
- database_cross_reference “GOC:go_curators”

Added

ureteric bud development definition “The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.”
- database_cross_reference “GOC:curators”

uridine biosynthetic process `http://purl.obolibrary.org/obo/GO_0046109`

Removed

uridine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids.”
- database_cross_reference “GOC:go_curators”

Added

uridine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids.”
- database_cross_reference “GOC:curators”

uridine catabolic process `http://purl.obolibrary.org/obo/GO_0006218`

Removed

uridine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids.”
- database_cross_reference “GOC:go_curators”

Added

uridine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids.”
- database_cross_reference “GOC:curators”

uridine metabolic process `http://purl.obolibrary.org/obo/GO_0046108`

Removed

uridine metabolic process definition “The chemical reactions and pathways involving uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids.”
- database_cross_reference “GOC:go_curators”

Added

uridine metabolic process definition “The chemical reactions and pathways involving uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids.”
- database_cross_reference “GOC:curators”

uridine transmembrane transport `http://purl.obolibrary.org/obo/GO_0015862`

Removed

uridine transmembrane transport definition “The directed movement of uridine, uracil riboside, across a lipid bilayer, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:go_curators”

Added

uridine transmembrane transport definition “The directed movement of uridine, uracil riboside, across a lipid bilayer, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:curators”

uridine transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015213`

Removed

uridine transmembrane transporter activity definition “Enables the transfer of uridine, uracil riboside, from one side of a membrane to the other.”
- database_cross_reference “GOC:go_curators”

Added

uridine transmembrane transporter activity definition “Enables the transfer of uridine, uracil riboside, from one side of a membrane to the other.”
- database_cross_reference “GOC:curators”

urocanate hydratase activity `http://purl.obolibrary.org/obo/GO_0016153`

Removed

urocanate hydratase activity database_cross_reference “Reactome:R-HSA-70903”
- label “urocanate + H2O => 4-imidazolone-5-propionate”

Added

urocanate hydratase activity database_cross_reference “Reactome:R-HSA-70903”
- label “urocanate + H2O => 4-imidazolone-5-propanoate”

urogenital system development `http://purl.obolibrary.org/obo/GO_0001655`

Removed

urogenital system development definition “The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure.”
- database_cross_reference “GOC:go_curators”

Added

urogenital system development definition “The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure.”
- database_cross_reference “GOC:curators”

uroporphyrin-III C-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0004851`

Removed

uroporphyrin-III C-methyltransferase activity definition “Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2.”
- database_cross_reference “EC:2.1.1.107”

Added

uroporphyrin-III C-methyltransferase activity definition “Catalysis of the reaction: uroporphyrinogen III + 2 S-adenosyl-L-methionine = precorrin-2 + 2 S-adenosyl-L-homocysteine + H+.”
- database_cross_reference “RHEA:32459”

vacuolar acidification `http://purl.obolibrary.org/obo/GO_0007035`

Removed

vacuolar acidification definition “Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion.”
- database_cross_reference “GOC:jid”

Added

vacuolar acidification definition “Any process that reduces the pH of the vacuole, corresponding to an increase in hydrogen ion concentration.”
- database_cross_reference “GOC:jid”

vacuolar sorting signal receptor activity `http://purl.obolibrary.org/obo/GO_0010209`

Removed

vacuolar sorting signal receptor activity label “vacuolar sorting signal binding”
vacuolar sorting signal receptor activity SubClassOf signal sequence binding

Added

vacuolar sorting signal receptor activity label “vacuolar sorting signal receptor activity”
vacuolar sorting signal receptor activity term tracker item “https://github.com/geneontology/go-ontology/issues/31410”^^anyURI
vacuolar sorting signal receptor activity has_related_synonym “vacuolar sorting signal binding”
vacuolar sorting signal receptor activity SubClassOf cargo receptor activity

ventral cord development `http://purl.obolibrary.org/obo/GO_0007419`

Removed

ventral cord development definition “The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms.”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:30826502”

Added

ventral cord development definition “The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:bf”
- database_cross_reference “PMID:30826502”

ventral midline development `http://purl.obolibrary.org/obo/GO_0007418`

Removed

ventral midline development definition “The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate.”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:12075342”

Added

ventral midline development definition “The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:bf”
- database_cross_reference “PMID:12075342”

versatile peroxidase activity `http://purl.obolibrary.org/obo/GO_0052750`

Removed

versatile peroxidase activity definition “Catalysis of the reaction: reactive black 5 + hydrogen peroxide = oxidized reactive black 5 + 2 H2O.”
- database_cross_reference “RHEA:22396”

Added

versatile peroxidase activity definition “Catalysis of the reaction: reactive black 5 + H2O2 = oxidized reactive black 5 + 2 H2O.”
- database_cross_reference “RHEA:22396”

versicolorin B synthase activity `http://purl.obolibrary.org/obo/GO_0046572`

Removed

versicolorin B synthase activity definition “Catalysis of the reaction: versiconal = versicolorin B + H2O.”
- database_cross_reference “PMID:8784203”
- database_cross_reference “MetaCyc:RXN-9494”
versicolorin B synthase activity SubClassOf carbon-oxygen lyase activity

Added

versicolorin B synthase activity definition “Catalysis of the reaction: (2S-3S)-versiconal hemiacetal = versicolorin B + H2O.”
- database_cross_reference “PMID:8784203”
- database_cross_reference “RHEA:33859”
versicolorin B synthase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31620”^^anyURI
versicolorin B synthase activity SubClassOf hydro-lyase activity

very long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0035380`

Removed

very long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase activity label “very long-chain-3-hydroxyacyl-CoA dehydrogenase activity”
very long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase activity definition “Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a very long-chain fatty acid residue. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.”
- database_cross_reference “GOC:pde”
very long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase activity SubClassOf oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Added

very long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase activity has_broad_synonym “very long-chain-3-hydroxyacyl-CoA dehydrogenase activity”
very long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase activity label “very long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase activity”
very long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase activity database_cross_reference “RHEA:78927”
very long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase activity definition “Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a very long-chain fatty acid residue. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.”
- database_cross_reference “RHEA:78927”
very long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase activity SubClassOf (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity

very long-chain fatty acid biosynthetic process `http://purl.obolibrary.org/obo/GO_0042761`

Added

very long-chain fatty acid biosynthetic process narrowMatch PWY-5080
very long-chain fatty acid biosynthetic process narrowMatch PWY-7036
very long-chain fatty acid biosynthetic process database_cross_reference “MetaCyc:PWY-7036”
very long-chain fatty acid biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI

very long-chain fatty acid omega-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0140692`

Added

very long-chain fatty acid-CoA ligase activity `http://purl.obolibrary.org/obo/GO_0031957`

Added

very long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:43748”
very long-chain fatty acid-CoA ligase activity narrowMatch 33639
very long-chain fatty acid-CoA ligase activity narrowMatch 83111
very long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:33639”
very long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:83111”
very long-chain fatty acid-CoA ligase activity narrowMatch 83403
very long-chain fatty acid-CoA ligase activity database_cross_reference “RHEA:83403”
very long-chain fatty acid-CoA ligase activity narrowMatch 43748

very long-chain fatty acyl-CoA hydrolase activity `http://purl.obolibrary.org/obo/GO_0052817`

Added

very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity `http://purl.obolibrary.org/obo/GO_0102158`

Added

very-long-chain 3-oxoacyl-CoA reductase activity `http://purl.obolibrary.org/obo/GO_0141040`

Added

very-long-chain enoyl-CoA reductase activity `http://purl.obolibrary.org/obo/GO_0102758`

Added

very-long-chain fatty acyl-CoA dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0017099`

Added

very-long-chain fatty acyl-CoA oxidase activity `http://purl.obolibrary.org/obo/GO_0044535`

Added

vesicle-mediated transport between endosomal compartments `http://purl.obolibrary.org/obo/GO_0098927`

Added

vesicle-mediated transport between endosomal compartments SubClassOf intercellular transport

virus receptor activity `http://purl.obolibrary.org/obo/GO_0001618`

Added

virus receptor activity database_cross_reference “Reactome:R-HSA-9922480”
- label “Dengue virion gets internalized”

visceral muscle development `http://purl.obolibrary.org/obo/GO_0007522`

Removed

visceral muscle development definition “The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure.”
- database_cross_reference “GOC:go_curators”

Added

visceral muscle development definition “The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure.”
- database_cross_reference “GOC:curators”

vitamin E metabolic process `http://purl.obolibrary.org/obo/GO_0042360`

Removed

vitamin E metabolic process database_cross_reference “Reactome:R-HSA-8877627”
- label “Vitamin E”

Added

vitamin E metabolic process database_cross_reference “Reactome:R-HSA-8877627”
- label “Vitamin E transport”

vitamin biosynthetic process `http://purl.obolibrary.org/obo/GO_0009110`

Removed

vitamin biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “ISBN:0198506732”

Added

vitamin biosynthetic process definition “The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.”
- database_cross_reference “GOC:curators”
- database_cross_reference “ISBN:0198506732”

vitexin 2’‘-O-rhamnoside 7-O-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0033801`

Removed

vitexin 2’‘-O-rhamnoside 7-O-methyltransferase activity definition “Catalysis of the reaction: S-adenosyl-L-methionine + vitexin 2’‘-O-beta-L-rhamnoside = S-adenosyl-L-homocysteine + 7-O-methylvitexin 2’‘-O-beta-L-rhamnoside.”
- database_cross_reference “EC:2.1.1.153”

Added

vitexin 2’‘-O-rhamnoside 7-O-methyltransferase activity definition “Catalysis of the reaction: S-adenosyl-L-methionine + vitexin 2’‘-O-beta-L-rhamnoside = S-adenosyl-L-homocysteine + 7-O-methylvitexin 2’‘-O-beta-L-rhamnoside.”
- database_cross_reference “RHEA:11432”

voltage-gated calcium channel activity `http://purl.obolibrary.org/obo/GO_0005245`

Added

voltage-gated calcium channel activity database_cross_reference “Reactome:R-HSA-9905934”
- label “CaV3.2 (CACNA1H:CACNA2D1:CACNB1,2,3:CACNG7) transports calcium from the extracellular region to the cytosol”

water-soluble vitamin biosynthetic process `http://purl.obolibrary.org/obo/GO_0042364`

Added

water-soluble vitamin biosynthetic process database_cross_reference “Reactome:R-HSA-196849”
- label “Metabolism of water-soluble vitamins and cofactors”

xanthine biosynthetic process `http://purl.obolibrary.org/obo/GO_0046111`

Removed

xanthine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids.”
- database_cross_reference “GOC:go_curators”

Added

xanthine biosynthetic process definition “The chemical reactions and pathways resulting in the formation of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids.”
- database_cross_reference “GOC:curators”

xanthine catabolic process `http://purl.obolibrary.org/obo/GO_0009115`

Removed

xanthine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids.”
- database_cross_reference “GOC:go_curators”

Added

xanthine catabolic process definition “The chemical reactions and pathways resulting in the breakdown of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids.”
- database_cross_reference “GOC:curators”

xanthine metabolic process `http://purl.obolibrary.org/obo/GO_0046110`

Removed

xanthine metabolic process definition “The chemical reactions and pathways involving xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids.”
- database_cross_reference “GOC:go_curators”

Added

xanthine metabolic process definition “The chemical reactions and pathways involving xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids.”
- database_cross_reference “GOC:curators”

xanthine oxidase activity `http://purl.obolibrary.org/obo/GO_0004855`

Removed

xanthine oxidase activity definition “Catalysis of the reaction: xanthine + H2O + O2 = urate + hydrogen peroxide.”
- database_cross_reference “EC:1.17.3.2”

Added

xanthine oxidase activity definition “Catalysis of the reaction: xanthine + H2O + O2 = urate + H2O2.”
- database_cross_reference “EC:1.17.3.2”

xanthophyll biosynthetic process `http://purl.obolibrary.org/obo/GO_0016123`

Removed

xanthophyll biosynthetic process definition “The chemical reactions and pathways resulting in the formation of xanthophylls, oxygen-containing carotenoids.”
- database_cross_reference “GOC:go_curators”

Added

xanthophyll biosynthetic process definition “The chemical reactions and pathways resulting in the formation of xanthophylls, oxygen-containing carotenoids.”
- database_cross_reference “GOC:curators”

xanthophyll catabolic process `http://purl.obolibrary.org/obo/GO_0016124`

Removed

xanthophyll catabolic process definition “The chemical reactions and pathways resulting in the breakdown of xanthophylls, oxygen-containing carotenoids.”
- database_cross_reference “GOC:go_curators”

Added

xanthophyll catabolic process definition “The chemical reactions and pathways resulting in the breakdown of xanthophylls, oxygen-containing carotenoids.”
- database_cross_reference “GOC:curators”

xenobiotic export from cell `http://purl.obolibrary.org/obo/GO_0046618`

Removed

xenobiotic export from cell definition “The directed movement of a xenobiotic from a cell, into the extracellular region. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:krc”

Added

xenobiotic export from cell definition “The directed movement of a xenobiotic from a cell, into the extracellular region. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:krc”

xenobiotic transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0042910`

Removed

xenobiotic transmembrane transporter activity definition “Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:krc”

Added

xenobiotic transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9913128”
- label “TetA exports tetracyclines”
xenobiotic transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9911512”
- label “AcrA:AcrB:TolC transports antibiotics from the cytosol to the periplasm”
xenobiotic transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9914089”
- label “MdtE:MdtF:TolC exports beta-lactams to the periplasm”
xenobiotic transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9913437”
- label “Pef exports fluoroquinolones”
xenobiotic transmembrane transporter activity definition “Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:krc”
xenobiotic transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9913672”
- label “OqxA exports fluoroquinolones”
xenobiotic transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9911517”
- label “MdfA transports tetracyclines from the cytosol to the periplasmic space”
xenobiotic transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9913106”
- label “TetB exports tetracyclines”
xenobiotic transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9931565”
- label “EmrE dimer exports xenobiotics to periplasm”
xenobiotic transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9931163”
- label “Gdx dimer exports cationic aromatics to periplasm”

xenobiotic transport `http://purl.obolibrary.org/obo/GO_0042908`

Removed

xenobiotic transport definition “The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “GOC:krc”

Added

xenobiotic transport definition “The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.”
- database_cross_reference “GOC:curators”
- database_cross_reference “GOC:krc”

xylan biosynthetic process `http://purl.obolibrary.org/obo/GO_0045492`

Removed

xylan biosynthetic process definition “The chemical reactions and pathways resulting in the formation of xylan, a polymer containing a beta-1,4-linked D-xylose backbone.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:11931668”

Added

xylan biosynthetic process definition “The chemical reactions and pathways resulting in the formation of xylan, a polymer containing a beta-1,4-linked D-xylose backbone.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:11931668”

xylan catabolic process `http://purl.obolibrary.org/obo/GO_0045493`

Removed

xylan catabolic process definition “The chemical reactions and pathways resulting in the breakdown of xylan, a polymer containing a beta-1,4-linked D-xylose backbone.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:11931668”

Added

xylan catabolic process definition “The chemical reactions and pathways resulting in the breakdown of xylan, a polymer containing a beta-1,4-linked D-xylose backbone.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:11931668”

xylan metabolic process `http://purl.obolibrary.org/obo/GO_0045491`

Removed

xylan metabolic process definition “The chemical reactions and pathways involving xylan, a polymer containing a beta-1,4-linked D-xylose backbone.”
- database_cross_reference “GOC:go_curators”
- database_cross_reference “PMID:11931668”

Added

xylan metabolic process definition “The chemical reactions and pathways involving xylan, a polymer containing a beta-1,4-linked D-xylose backbone.”
- database_cross_reference “GOC:curators”
- database_cross_reference “PMID:11931668”

xylene catabolic process `http://purl.obolibrary.org/obo/GO_0042184`

Removed

xylene catabolic process definition “The chemical reactions and pathways resulting in the breakdown of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene.”
- database_cross_reference “GOC:go_curators”

Added

xylene catabolic process definition “The chemical reactions and pathways resulting in the breakdown of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene.”
- database_cross_reference “GOC:curators”

xylitol catabolic process to D-xylulose 5-phosphate `http://purl.obolibrary.org/obo/GO_0019697`

Added

xylitol catabolic process to D-xylulose 5-phosphate database_cross_reference “MetaCyc:PWY-8393”
xylitol catabolic process to D-xylulose 5-phosphate narrowMatch LARABITOLUTIL-PWY
xylitol catabolic process to D-xylulose 5-phosphate term tracker item “https://github.com/geneontology/go-ontology/issues/31634”^^anyURI
xylitol catabolic process to D-xylulose 5-phosphate narrowMatch PWY-8393

xylulose catabolic process `http://purl.obolibrary.org/obo/GO_0005998`

Removed

xylulose catabolic process database_cross_reference “MetaCyc:XYLCAT-PWY”

yeast-form cell wall `http://purl.obolibrary.org/obo/GO_0030445`

Removed

yeast-form cell wall definition “The wall surrounding a cell of a dimorphic fungus growing in the single-cell budding yeast form, in contrast to the filamentous or hyphal form.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”

Added

yeast-form cell wall definition “The wall surrounding a cell of a dimorphic fungus growing in the single-cell budding yeast form, in contrast to the filamentous or hyphal form.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”
- database_cross_reference “PMID:36266346”

zinc ion export from vacuole `http://purl.obolibrary.org/obo/GO_0140147`

Added

zinc ion export from vacuole SubClassOf intercellular transport

zinc ion import into lysosome `http://purl.obolibrary.org/obo/GO_0140916`

Added

zinc ion import into lysosome SubClassOf intercellular transport

zinc ion import into mitochondrion `http://purl.obolibrary.org/obo/GO_0140917`

Added

zinc ion import into mitochondrion SubClassOf intercellular transport

zinc ion import into secretory vesicle `http://purl.obolibrary.org/obo/GO_0140914`

Added

zinc ion import into secretory vesicle SubClassOf intercellular transport

zinc ion import into synaptic vesicle `http://purl.obolibrary.org/obo/GO_0099180`

Added

zinc ion import into synaptic vesicle SubClassOf intercellular transport

zinc ion transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0005385`

Added

zinc ion transmembrane transporter activity database_cross_reference “Reactome:R-HSA-9928035”
- label “ZnuABC transports Zn2+ to cytosol”

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go-ontology

Ontology comparison

Left

Right

Ontology imports

Ontology annotations

Removed

Added

‘de novo’ L-methionine biosynthetic process http://purl.obolibrary.org/obo/GO_0071266

Removed

Added

‘de novo’ pyridoxal 5’-phosphate biosynthetic process http://purl.obolibrary.org/obo/GO_0036001

Added

‘de novo’ pyrimidine nucleobase biosynthetic process http://purl.obolibrary.org/obo/GO_0006207

Removed

Added

(2E)-butenoyl-CoA hydratase activity http://purl.obolibrary.org/obo/GO_0120092

Added

(2E)-enoyl-CoA hydratase activity http://purl.obolibrary.org/obo/GO_0080023

Added

(2R)-2-hydroxyacid dehydrogenase (NAD+) activity http://purl.obolibrary.org/obo/GO_0140175

Added

(2R)-2-hydroxyacid dehydrogenase (NADP+) activity http://purl.obolibrary.org/obo/GO_0050578

Added

(2R)-2-hydroxycarboxylate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0140174

Added

(2S)-2-aminobutanoate:2-oxoglutarate transaminase activity http://purl.obolibrary.org/obo/GO_0120554

Removed

Added

(3R)-2’-hydroxyisoflavanone reductase (NADP+) activity http://purl.obolibrary.org/obo/GO_0140860

Added

(3R)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity http://purl.obolibrary.org/obo/GO_0106386

Added

(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity http://purl.obolibrary.org/obo/GO_0019171

Added

(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity http://purl.obolibrary.org/obo/GO_0003857

Added

(4S)-4-hydroxy-L-glutamate:2-oxoglutarate transaminase activity http://purl.obolibrary.org/obo/GO_0047578

Removed

Added

(R)-2-hydroxyglutarate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0051990

Added

(R)-3-amino-2-methylpropionate:pyruvate transaminase activity http://purl.obolibrary.org/obo/GO_0047305

Removed

Added

(R)-6-hydroxynicotine oxidase activity http://purl.obolibrary.org/obo/GO_0018530

Removed

Added

(R)-mandelate catabolic process to benzoate http://purl.obolibrary.org/obo/GO_0019597

Removed

Added

(R)-mandelate catabolic process to catechol http://purl.obolibrary.org/obo/GO_0019598

Removed

Added

(R,S)-4-hydroxy-2-oxoglutarate aldolase activity http://purl.obolibrary.org/obo/GO_0008700

Added

(RS)-norcoclaurine 6-O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030786

Added

(S)-2-hydroxy-acid oxidase activity http://purl.obolibrary.org/obo/GO_0003973

Removed

Added

(S)-2-hydroxyglutarate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0047545

Added

(S)-3-amino-2-methylpropionate:2-oxoglutarate transaminase activity http://purl.obolibrary.org/obo/GO_0047298

Removed

Added

(S)-6-hydroxynicotine oxidase activity http://purl.obolibrary.org/obo/GO_0018531

Removed

Added

(S)-tetrahydroprotoberberine N-methyltransferase activity http://purl.obolibrary.org/obo/GO_0030782

Added

1,2-diacylglycerol 3-beta-galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0046509

Added

1,2-dichloroethane catabolic process http://purl.obolibrary.org/obo/GO_0019260

Removed

Added

1,4-dihydroxy-2-naphthoate polyprenyltransferase activity http://purl.obolibrary.org/obo/GO_0046428

Added

1,4-lactonase activity http://purl.obolibrary.org/obo/GO_0050490

Added

‘de novo’ L-methionine biosynthetic process `http://purl.obolibrary.org/obo/GO_0071266`

‘de novo’ pyridoxal 5’-phosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0036001`

‘de novo’ pyrimidine nucleobase biosynthetic process `http://purl.obolibrary.org/obo/GO_0006207`

(2E)-butenoyl-CoA hydratase activity `http://purl.obolibrary.org/obo/GO_0120092`

(2E)-enoyl-CoA hydratase activity `http://purl.obolibrary.org/obo/GO_0080023`

(2R)-2-hydroxyacid dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0140175`

(2R)-2-hydroxyacid dehydrogenase (NADP+) activity `http://purl.obolibrary.org/obo/GO_0050578`

(2R)-2-hydroxycarboxylate dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0140174`

(2S)-2-aminobutanoate:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0120554`

(3R)-2’-hydroxyisoflavanone reductase (NADP+) activity `http://purl.obolibrary.org/obo/GO_0140860`

(3R)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0106386`

(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity `http://purl.obolibrary.org/obo/GO_0019171`

(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0003857`

(4S)-4-hydroxy-L-glutamate:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0047578`

(R)-2-hydroxyglutarate dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0051990`

(R)-3-amino-2-methylpropionate:pyruvate transaminase activity `http://purl.obolibrary.org/obo/GO_0047305`

(R)-6-hydroxynicotine oxidase activity `http://purl.obolibrary.org/obo/GO_0018530`

(R)-mandelate catabolic process to benzoate `http://purl.obolibrary.org/obo/GO_0019597`

(R)-mandelate catabolic process to catechol `http://purl.obolibrary.org/obo/GO_0019598`

(R,S)-4-hydroxy-2-oxoglutarate aldolase activity `http://purl.obolibrary.org/obo/GO_0008700`

(RS)-norcoclaurine 6-O-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0030786`

(S)-2-hydroxy-acid oxidase activity `http://purl.obolibrary.org/obo/GO_0003973`

(S)-2-hydroxyglutarate dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0047545`

(S)-3-amino-2-methylpropionate:2-oxoglutarate transaminase activity `http://purl.obolibrary.org/obo/GO_0047298`

(S)-6-hydroxynicotine oxidase activity `http://purl.obolibrary.org/obo/GO_0018531`

(S)-tetrahydroprotoberberine N-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0030782`

1,2-diacylglycerol 3-beta-galactosyltransferase activity `http://purl.obolibrary.org/obo/GO_0046509`

1,2-dichloroethane catabolic process `http://purl.obolibrary.org/obo/GO_0019260`

1,4-dihydroxy-2-naphthoate polyprenyltransferase activity `http://purl.obolibrary.org/obo/GO_0046428`

1,4-lactonase activity `http://purl.obolibrary.org/obo/GO_0050490`

1,5-anhydro-D-fructose reductase activity `http://purl.obolibrary.org/obo/GO_0050571`

1-acylglycerol-3-phosphate O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0003841`

1-acylglycerophosphocholine O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0047184`

1-acylglycerophosphoethanolamine O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0106262`

1-acylglycerophosphoserine O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0106263`

1-alkenylglycerophosphoethanolamine O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0047166`

1-alkyl-2-acetylglycerophosphocholine esterase activity `http://purl.obolibrary.org/obo/GO_0003847`

1-alkylglycerophosphocholine O-acetyltransferase activity `http://purl.obolibrary.org/obo/GO_0047192`

1-alkylglycerophosphocholine O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0047191`

1-aminocyclopropane-1-carboxylate catabolic process `http://purl.obolibrary.org/obo/GO_0042217`

1-aminocyclopropane-1-carboxylate synthase activity `http://purl.obolibrary.org/obo/GO_0016847`

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate catabolic process `http://purl.obolibrary.org/obo/GO_1903101`

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process `http://purl.obolibrary.org/obo/GO_1903100`

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process `http://purl.obolibrary.org/obo/GO_1902634`

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process `http://purl.obolibrary.org/obo/GO_1902633`

1-phosphatidylinositol 4-kinase activator activity `http://purl.obolibrary.org/obo/GO_0098744`

1-phosphatidylinositol binding `http://purl.obolibrary.org/obo/GO_0005545`

1-phosphatidylinositol-3-phosphate 5-kinase activity `http://purl.obolibrary.org/obo/GO_0000285`

1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity `http://purl.obolibrary.org/obo/GO_0046934`

1-phosphatidylinositol-4-phosphate 5-kinase activity `http://purl.obolibrary.org/obo/GO_0016308`

1-phosphatidylinositol-5-phosphate 4-kinase activity `http://purl.obolibrary.org/obo/GO_0016309`

11-beta-hydroxysteroid dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0070523`

11-beta-hydroxysteroid dehydrogenase (NADP+) activity `http://purl.obolibrary.org/obo/GO_0070524`

17-beta-hydroxysteroid dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0044594`

17-beta-hydroxysteroid dehydrogenase (NADP+) activity `http://purl.obolibrary.org/obo/GO_0072582`

18S rRNA cytidine N-acetyltransferase activity `http://purl.obolibrary.org/obo/GO_1990883`

1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate transaminase activity `http://purl.obolibrary.org/obo/GO_0047311`

2’,3’-cyclic-nucleotide 2’-phosphodiesterase activity `http://purl.obolibrary.org/obo/GO_0008663`

2’,3’-cyclic-nucleotide 3’-phosphodiesterase activity `http://purl.obolibrary.org/obo/GO_0004113`

2’-deoxyribonucleoside biosynthetic process `http://purl.obolibrary.org/obo/GO_0046120`

2’-deoxyribonucleoside catabolic process `http://purl.obolibrary.org/obo/GO_0046121`