go-ontology

Ontology comparison

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Ontology IRI: http://purl.obolibrary.org/obo/go.owl
Version IRI: http://purl.obolibrary.org/obo/go/releases/2026-07-26/go.owl
Loaded from: file:/__w/go-ontology/go-ontology/src/ontology/go-lastrelease.owl

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Ontology IRI: http://purl.obolibrary.org/obo/go.owl
Version IRI: http://purl.obolibrary.org/obo/go/releases/2026-08-18/go.owl
Loaded from: file:/__w/go-ontology/go-ontology/src/ontology/go.ofn

Ontology imports

Ontology annotations

Removed

versionInfo “2026-07-26”

Added

versionInfo “2026-08-18”

‘de novo’ NAD+ biosynthetic process from L-tryptophan `http://purl.obolibrary.org/obo/GO_0034354`

Added

‘de novo’ NAD+ biosynthetic process from L-tryptophan term tracker item “https://github.com/geneontology/go-ontology/issues/32456”^^anyURI

4’-phosphopantetheine phosphatase activity `http://purl.obolibrary.org/obo/GO_7770095`

Added

Class: 4’-phosphopantetheine phosphatase activity
4’-phosphopantetheine phosphatase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32389”^^anyURI
4’-phosphopantetheine phosphatase activity created by “ai4c-agent”
4’-phosphopantetheine phosphatase activity creation date “2026-07-30T17:40:49Z”
4’-phosphopantetheine phosphatase activity database_cross_reference “EC:3.1.3.110”
4’-phosphopantetheine phosphatase activity database_cross_reference “KEGG_REACTION:R10748”
4’-phosphopantetheine phosphatase activity database_cross_reference “MetaCyc:RXN-24222”
4’-phosphopantetheine phosphatase activity database_cross_reference “RHEA:68328”
4’-phosphopantetheine phosphatase activity has_exact_synonym “pantetheine-4’-phosphate phosphatase activity”
4’-phosphopantetheine phosphatase activity has_exact_synonym “phosphopantetheine phosphatase activity”
4’-phosphopantetheine phosphatase activity has_obo_namespace “molecular_function”
4’-phosphopantetheine phosphatase activity id “GO:7770095”
4’-phosphopantetheine phosphatase activity exactMatch RXN-24222
4’-phosphopantetheine phosphatase activity exactMatch 3.1.3.110
4’-phosphopantetheine phosphatase activity exactMatch 68328
4’-phosphopantetheine phosphatase activity definition “Catalysis of the reaction: (R)-4’-phosphopantetheine + H2O = (R)-pantetheine + phosphate.”
- database_cross_reference “EC:3.1.3.110”
- database_cross_reference “PMID:18678912”
- database_cross_reference “PMID:35896750”
- database_cross_reference “PMID:27322068”
- database_cross_reference “RHEA:68328”
4’-phosphopantetheine phosphatase activity label “4’-phosphopantetheine phosphatase activity”
4’-phosphopantetheine phosphatase activity SubClassOf phosphatase activity

ABC-type cadmium transporter activity `http://purl.obolibrary.org/obo/GO_0015434`

Added

ABC-type cadmium transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/20824”^^anyURI
ABC-type cadmium transporter activity broadMatch 12132
ABC-type cadmium transporter activity comment “Note that RHEA:12132 represents both the ABC and the P-type cadmium transporters.”

ATP-dependent folded protein transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_7770098`

Added

Class: ATP-dependent folded protein transmembrane transporter activity
ATP-dependent folded protein transmembrane transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/32394”^^anyURI
ATP-dependent folded protein transmembrane transporter activity created by “ai4c-agent”
ATP-dependent folded protein transmembrane transporter activity creation date “2026-08-04T00:40:41Z”
ATP-dependent folded protein transmembrane transporter activity has_exact_synonym “ATPase-coupled folded protein transmembrane transporter activity”
ATP-dependent folded protein transmembrane transporter activity has_exact_synonym “folded protein-transporting ATPase activity”
ATP-dependent folded protein transmembrane transporter activity has_obo_namespace “molecular_function”
ATP-dependent folded protein transmembrane transporter activity has_related_synonym “folded protein translocase activity”
ATP-dependent folded protein transmembrane transporter activity id “GO:7770098”
ATP-dependent folded protein transmembrane transporter activity definition “Enables the transfer of a protein in its native, folded conformation from one side of a membrane to the other, coupled to the hydrolysis of ATP and without unfolding of the substrate, according to the reaction: ATP + H2O + protein[side 1] = ADP + phosphate + protein[side 2].”
- database_cross_reference “PMID:32042153”
- database_cross_reference “PMID:40410623”
- database_cross_reference “PMID:31988523”
ATP-dependent folded protein transmembrane transporter activity comment “This activity is exemplified by the mitochondrial inner membrane AAA-ATPase Bcs1 (BCS1L in mammals), which translocates the folded, 2Fe-2S-loaded Rieske iron-sulfur protein from the mitochondrial matrix across the inner membrane during respiratory complex III assembly. Unlike most AAA+ protein translocases, the substrate is not threaded through an axial pore in an extended conformation; in Bcs1 it passes between two aqueous vestibules separated by a seal, in an airlock-like mechanism that preserves the membrane permeability barrier. Do not use this term for the separable channel and motor activities of multi-subunit translocases; for those, consider ‘transmembrane protein transporter activity ; GO:0008320’ and ‘protein translocation chaperone activity ; GO:0140388’.”
ATP-dependent folded protein transmembrane transporter activity label “ATP-dependent folded protein transmembrane transporter activity”
ATP-dependent folded protein transmembrane transporter activity SubClassOf protein-transporting ATPase activity

ATP-dependent protein-RNA complex displacement activity `http://purl.obolibrary.org/obo/GO_7770106`

Added

Class: ATP-dependent protein-RNA complex displacement activity
ATP-dependent protein-RNA complex displacement activity term tracker item “https://github.com/geneontology/go-ontology/issues/32232”^^anyURI
ATP-dependent protein-RNA complex displacement activity created by “ai4c-agent”
ATP-dependent protein-RNA complex displacement activity creation date “2026-08-07T16:59:22Z”
ATP-dependent protein-RNA complex displacement activity has_broad_synonym “RNP remodeling ATPase activity”
ATP-dependent protein-RNA complex displacement activity has_exact_synonym “ATP-dependent RNA-protein complex displacement activity”
ATP-dependent protein-RNA complex displacement activity has_exact_synonym “RNPase activity”
ATP-dependent protein-RNA complex displacement activity has_obo_namespace “molecular_function”
ATP-dependent protein-RNA complex displacement activity id “GO:7770106”
ATP-dependent protein-RNA complex displacement activity definition “An activity that displaces a protein or protein complex from RNA in a ribonucleoprotein (RNP) complex, driven by ATP hydrolysis.”
- database_cross_reference “PMID:28864812”
- database_cross_reference “PMID:11175897”
- database_cross_reference “PMID:39122693”
- database_cross_reference “PMID:15118161”
ATP-dependent protein-RNA complex displacement activity comment “Analogous to the DNA-side activity GO:0061995 (ATP-dependent protein-DNA complex displacement activity). The community-used term "RNPase" refers to this activity.”
ATP-dependent protein-RNA complex displacement activity label “ATP-dependent protein-RNA complex displacement activity”
ATP-dependent protein-RNA complex displacement activity SubClassOf ATP-dependent activity, acting on RNA

D-sorbitol biosynthetic process `http://purl.obolibrary.org/obo/GO_0006061`

Added

D-sorbitol biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/32269”^^anyURI

D-xylose reductase (NADPH) activity `http://purl.obolibrary.org/obo/GO_0032866`

Added

D-xylose reductase (NADPH) activity term tracker item “https://github.com/geneontology/go-ontology/issues/27881”^^anyURI
D-xylose reductase (NADPH) activity SubClassOf alcohol dehydrogenase (NADP+) activity

ER lumen protein retrieval receptor activity `http://purl.obolibrary.org/obo/GO_0046923`

Removed

ER lumen protein retrieval receptor activity has_exact_synonym “endoplasmic reticulum retention sequence binding”
ER lumen protein retrieval receptor activity has_narrow_synonym “DDEL signal sequence receptor activity”
ER lumen protein retrieval receptor activity has_narrow_synonym “ER retention sequence binding”
ER lumen protein retrieval receptor activity has_narrow_synonym “HDEL signal sequence receptor activity”
ER lumen protein retrieval receptor activity has_narrow_synonym “KDEL signal sequence receptor activity”
ER lumen protein retrieval receptor activity definition “Binding to an endoplasmic reticulum (ER) retention sequence, a short stretch of amino acids found in a protein that acts as a signal to retain the protein within the ER.”
- database_cross_reference “GOC:ai”
ER lumen protein retrieval receptor activity SubClassOf signal sequence receptor activity

Added

ER lumen protein retrieval receptor activity term tracker item “https://github.com/geneontology/go-ontology/issues/32307”^^anyURI
ER lumen protein retrieval receptor activity has_related_synonym “DDEL signal sequence receptor activity”
ER lumen protein retrieval receptor activity has_related_synonym “ER retention sequence binding”
ER lumen protein retrieval receptor activity has_related_synonym “HDEL signal sequence receptor activity”
ER lumen protein retrieval receptor activity has_related_synonym “KDEL signal sequence receptor activity”
ER lumen protein retrieval receptor activity has_related_synonym “endoplasmic reticulum retention sequence binding”
ER lumen protein retrieval receptor activity definition “Binding to a C-terminal ER retrieval signal, such as KDEL, HDEL or DDEL, present on soluble lumenal proteins that have escaped from the endoplasmic reticulum (ER) to the Golgi, and mediating their return to the ER.”
- database_cross_reference “PMID:33037041”
ER lumen protein retrieval receptor activity SubClassOf cargo receptor activity
ER lumen protein retrieval receptor activity SubClassOf part of some retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

ER membrane protein retrieval receptor activity `http://purl.obolibrary.org/obo/GO_7770094`

Added

Class: ER membrane protein retrieval receptor activity
ER membrane protein retrieval receptor activity term tracker item “https://github.com/geneontology/go-ontology/issues/32307”^^anyURI
ER membrane protein retrieval receptor activity created by “ai4c-agent”
ER membrane protein retrieval receptor activity creation date “2026-07-29T19:05:05Z”
ER membrane protein retrieval receptor activity has_exact_synonym “endoplasmic reticulum membrane protein retrieval receptor activity”
ER membrane protein retrieval receptor activity has_narrow_synonym “KKXX motif binding”
ER membrane protein retrieval receptor activity has_narrow_synonym “KKXX signal receptor activity”
ER membrane protein retrieval receptor activity has_narrow_synonym “dilysine motif binding”
ER membrane protein retrieval receptor activity has_obo_namespace “molecular_function”
ER membrane protein retrieval receptor activity id “GO:7770094”
ER membrane protein retrieval receptor activity definition “Binding to a retrieval signal, such as a C-terminal KKXX/KXKX-type dilysine motif or an exposed transmembrane domain determinant, present on integral membrane proteins that have escaped from the endoplasmic reticulum (ER) to the Golgi, and mediating their return to the ER.”
- database_cross_reference “PMID:12972550”
ER membrane protein retrieval receptor activity label “ER membrane protein retrieval receptor activity”
ER membrane protein retrieval receptor activity SubClassOf cargo receptor activity
ER membrane protein retrieval receptor activity SubClassOf part of some retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

FAD regeneration via ETF:ETFQO system `http://purl.obolibrary.org/obo/GO_7770096`

Added

Class: FAD regeneration via ETF:ETFQO system
FAD regeneration via ETF:ETFQO system term tracker item “https://github.com/geneontology/go-ontology/issues/32355”^^anyURI
FAD regeneration via ETF:ETFQO system created by “ai4c-agent”
FAD regeneration via ETF:ETFQO system creation date “2026-07-30T22:03:00Z”
FAD regeneration via ETF:ETFQO system has_exact_synonym “ETF-ETFQO system”
FAD regeneration via ETF:ETFQO system has_exact_synonym “FAD regeneration via ETF-ETFQO system”
FAD regeneration via ETF:ETFQO system has_exact_synonym “reoxidation of reduced electron transfer flavoprotein”
FAD regeneration via ETF:ETFQO system has_obo_namespace “biological_process”
FAD regeneration via ETF:ETFQO system id “GO:7770096”
FAD regeneration via ETF:ETFQO system definition “A metabolic process that transfers electrons produced by FAD-dependent dehydrogenases involved in amino acid and lipid catabolism to the electron transport chain. Electrons released during FADH2 oxidation are transferred by electron-transfer flavoprotein (ETF) to ETF-ubiquinone oxidoreductase (ETF-QO), which in turn transfers them to ubiquinone and then to complex III of the electron transport chain.”
- database_cross_reference “PMID:28808132”
- database_cross_reference “PMID:33450351”
FAD regeneration via ETF:ETFQO system comment “In eukaryotes, FAD regeneration via the ETF:ETFQO system occurs in the mitochondrion, with ETF in the matrix and ETF-QO in the inner membrane. Some bacteria and archaea have a similar system, so no taxon constraint applies to this term. This term covers the ETF/ETF-QO route specifically; do not use it for flavoprotein dehydrogenases that reduce the quinone pool directly without ETF (for example succinate dehydrogenase, see GO:0006121), or for reoxidation of flavin by molecular oxygen in peroxisomes or the endoplasmic reticulum.”
FAD regeneration via ETF:ETFQO system label “FAD regeneration via ETF:ETFQO system”
FAD regeneration via ETF:ETFQO system SubClassOf respiratory electron transport chain
FAD regeneration via ETF:ETFQO system SubClassOf FAD metabolic process

FMN adenylyltransferase activity `http://purl.obolibrary.org/obo/GO_0003919`

Removed

FMN adenylyltransferase activity definition “Catalysis of the reaction: ATP + FMN = diphosphate + FAD.”
- database_cross_reference “EC:2.7.7.2”
- database_cross_reference “RHEA:17237”

Added

FMN adenylyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32345”^^anyURI
FMN adenylyltransferase activity definition “Catalysis of the reaction: FMN + ATP + H+ = FAD + diphosphate.”
- database_cross_reference “RHEA:17237”

L-arabinose reductase (NADPH) activity `http://purl.obolibrary.org/obo/GO_0032867`

Added

L-arabinose reductase (NADPH) activity term tracker item “https://github.com/geneontology/go-ontology/issues/27881”^^anyURI
L-arabinose reductase (NADPH) activity SubClassOf alcohol dehydrogenase (NADP+) activity

L-methionine cycle `http://purl.obolibrary.org/obo/GO_0033353`

Removed

L-methionine cycle definition “A cyclic series of interconversions involving S-adenosyl-L-homocysteine, L-homocysteine, L-methionine and S-adenosyl-L-methionine (SAM). Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of L-methionine.”
- database_cross_reference “PMID:31950558”
- database_cross_reference “PMID:39394448”

Added

L-methionine cycle term tracker item “https://github.com/geneontology/go-ontology/issues/32362”^^anyURI
L-methionine cycle definition “A cyclic series of interconversions involving S-adenosyl-L-homocysteine, L-homocysteine, L-methionine and S-adenosyl-L-methionine (SAM). Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of L-methionine.”
- database_cross_reference “PMID:32961717”
- database_cross_reference “PMID:31950558”
- database_cross_reference “PMID:39394448”
L-methionine cycle SubClassOf one-carbon metabolic process

NAD+ nucleosidase activity, cyclic ADP-ribose generating `http://purl.obolibrary.org/obo/GO_0061809`

Removed

Added

NAD+ nucleosidase activity, cyclic ADP-ribose generating term tracker item “https://github.com/geneontology/go-ontology/issues/32457”^^anyURI
NAD+ nucleosidase activity, cyclic ADP-ribose generating SubClassOf has part some cyclic ADP-ribose hydrolase activity

NADH-dependent peroxiredoxin activity `http://purl.obolibrary.org/obo/GO_0102039`

Removed

NADH-dependent peroxiredoxin activity SubClassOf peroxiredoxin activity

Added

NADH-dependent peroxiredoxin activity term tracker item “https://github.com/geneontology/go-ontology/issues/32372”^^anyURI
NADH-dependent peroxiredoxin activity SubClassOf peroxidase activity

P-type cadmium transporter activity `http://purl.obolibrary.org/obo/GO_0008551`

Removed

P-type cadmium transporter activity database_cross_reference “RHEA:12132”
P-type cadmium transporter activity exactMatch 12132

Added

P-type cadmium transporter activity term tracker item “https://github.com/geneontology/go-ontology/issues/20824”^^anyURI
P-type cadmium transporter activity broadMatch 12132
P-type cadmium transporter activity comment “Note that RHEA:12132 represents both the ABC and the P-type cadmium transporters.”

RADAR pathway `http://purl.obolibrary.org/obo/GO_0170074`

Added

RADAR pathway SubClassOf peroxisomal protein quality control

RNA (adenine-N6)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_7770107`

Added

Class: RNA (adenine-N6)-methyltransferase activity
RNA (adenine-N6)-methyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/27200”^^anyURI
RNA (adenine-N6)-methyltransferase activity created by “ai4c-agent”
RNA (adenine-N6)-methyltransferase activity creation date “2026-08-07T23:44:01Z”
RNA (adenine-N6)-methyltransferase activity has_exact_synonym “RNA (N6-adenosine)-methyltransferase activity”
RNA (adenine-N6)-methyltransferase activity has_exact_synonym “RNA m6A methyltransferase activity”
RNA (adenine-N6)-methyltransferase activity has_obo_namespace “molecular_function”
RNA (adenine-N6)-methyltransferase activity id “GO:7770107”
RNA (adenine-N6)-methyltransferase activity definition “Catalysis of the reaction: an adenosine in RNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in RNA + S-adenosyl-L-homocysteine + H+.”
- database_cross_reference “PMID:34023900”
- database_cross_reference “PMID:36736310”
RNA (adenine-N6)-methyltransferase activity label “RNA (adenine-N6)-methyltransferase activity”
RNA (adenine-N6)-methyltransferase activity SubClassOf N-methyltransferase activity
RNA (adenine-N6)-methyltransferase activity SubClassOf RNA methyltransferase activity

S-methylmethionine cycle `http://purl.obolibrary.org/obo/GO_0033528`

Removed

S-methylmethionine cycle definition “A cyclic series of interconversions involving S-methyl-L-methionine, S-adenosyl-L-homocysteine, S-adenosyl-L-methionine, L-homocysteine, and L-methionine. Converts the methionine group of adenosylmethionine back to free methionine, and may serve regulate the cellular adenosylmethionine level.”
- database_cross_reference “MetaCyc:PWY-5441”
- database_cross_reference “GOC:mah”

Added

S-methylmethionine cycle term tracker item “https://github.com/geneontology/go-ontology/issues/32362”^^anyURI
S-methylmethionine cycle definition “A cyclic series of interconversions involving S-methyl-L-methionine, S-adenosyl-L-homocysteine, S-adenosyl-L-methionine, L-homocysteine, and L-methionine. Converts the methionine group of S-adenosylmethionine back to free L-methionine, and may serve regulate the cellular adenosylmethionine level.”
- database_cross_reference “MetaCyc:PWY-5441”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:11337394”
S-methylmethionine cycle SubClassOf one-carbon metabolic process

Sca1 Ras guanyl-nucleotide exchange factor complex `http://purl.obolibrary.org/obo/GO_0170078`

Added

Class: Sca1 Ras guanyl-nucleotide exchange factor complex
Sca1 Ras guanyl-nucleotide exchange factor complex term tracker item “https://github.com/geneontology/go-ontology/issues/32432”^^anyURI
Sca1 Ras guanyl-nucleotide exchange factor complex created by “ew”
Sca1 Ras guanyl-nucleotide exchange factor complex creation date “2026-08-11T17:42:26Z”
Sca1 Ras guanyl-nucleotide exchange factor complex has_broad_synonym “Sca1 RasGEF complex”
Sca1 Ras guanyl-nucleotide exchange factor complex has_broad_synonym “Sca1 signaling complex”
Sca1 Ras guanyl-nucleotide exchange factor complex has_broad_synonym “Sca1-Aimless signaling complex”
Sca1 Ras guanyl-nucleotide exchange factor complex has_broad_synonym “Sca1-associated Ras guanyl-nucleotide exchange factor complex”
Sca1 Ras guanyl-nucleotide exchange factor complex has_obo_namespace “cellular_component”
Sca1 Ras guanyl-nucleotide exchange factor complex id “GO:0170078”
Sca1 Ras guanyl-nucleotide exchange factor complex definition “A protein complex found in Dictyostelium, containing the scaffold protein Sca1, the Ras guanine nucleotide exchange factors Aimless (RasGEFA) and RasGEFH, and PP2A components, which promotes RasC activation during chemotaxis.”
- database_cross_reference “PMID:20493808”
Sca1 Ras guanyl-nucleotide exchange factor complex label “Sca1 Ras guanyl-nucleotide exchange factor complex”
Sca1 Ras guanyl-nucleotide exchange factor complex SubClassOf Ras guanyl-nucleotide exchange factor complex

Sec body `http://purl.obolibrary.org/obo/GO_7770092`

Added

Class: Sec body
Sec body term tracker item “https://github.com/geneontology/go-ontology/issues/32313”^^anyURI
Sec body created by “ai4c-agent”
Sec body creation date “2026-07-28T23:40:49Z”
Sec body has_exact_synonym “sec-body”
Sec body has_obo_namespace “cellular_component”
Sec body id “GO:7770092”
Sec body definition “A condensate that forms reversibly in the cytoplasm under stress, notably amino acid starvation or salt stress, by coalescence of endoplasmic reticulum exit site (ERES) components including the scaffold protein Sec16 and COPII coat subunits. Sec bodies form through liquid-liquid phase separation and act as a protective reservoir for ERES components, permitting reversible shutdown of the early secretory pathway and promoting cell survival during stress.”
- database_cross_reference “PMID:25386913”
- database_cross_reference “PMID:36325988”
- database_cross_reference “PMID:31152627”
Sec body comment “A Sec body forms from components of an endoplasmic reticulum exit site (GO:0070971), which is progressively depleted as the Sec body grows; a Sec body is a distinct structure and is not part of an ER exit site.”
Sec body label “Sec body”
Sec body SubClassOf intracellular membraneless organelle
Sec body SubClassOf part of some cytoplasm

Sec body assembly `http://purl.obolibrary.org/obo/GO_7770093`

Added

Class: Sec body assembly
Sec body assembly term tracker item “https://github.com/geneontology/go-ontology/issues/32314”^^anyURI
Sec body assembly created by “ai4c-agent”
Sec body assembly creation date “2026-07-28T23:40:49Z”
Sec body assembly has_exact_synonym “Sec body formation”
Sec body assembly has_exact_synonym “sec-body assembly”
Sec body assembly has_obo_namespace “biological_process”
Sec body assembly id “GO:7770093”
Sec body assembly definition “The aggregation, arrangement and bonding together of a set of components to form a Sec body.”
- database_cross_reference “PMID:25386913”
- database_cross_reference “PMID:27874829”
Sec body assembly label “Sec body assembly”
Sec body assembly SubClassOf membraneless organelle assembly

Tim8-Tim13 complex `http://purl.obolibrary.org/obo/GO_7770104`

Added

Class: Tim8-Tim13 complex
Tim8-Tim13 complex term tracker item “https://github.com/geneontology/go-ontology/issues/32408”^^anyURI
Tim8-Tim13 complex created by “ai4c-agent”
Tim8-Tim13 complex creation date “2026-08-07T16:51:54Z”
Tim8-Tim13 complex has_exact_synonym “TIM8-13 complex”
Tim8-Tim13 complex has_obo_namespace “cellular_component”
Tim8-Tim13 complex id “GO:7770104”
Tim8-Tim13 complex definition “A chaperone complex located in the mitochondrial intermembrane space, composed of the small TIM proteins Tim8 and Tim13.”
- database_cross_reference “PMID:33355130”
- database_cross_reference “PMID:11101512”
Tim8-Tim13 complex label “Tim8-Tim13 complex”
Tim8-Tim13 complex SubClassOf mitochondrial intermembrane space chaperone complex

Tim9-Tim10 complex `http://purl.obolibrary.org/obo/GO_7770105`

Added

Class: Tim9-Tim10 complex
Tim9-Tim10 complex term tracker item “https://github.com/geneontology/go-ontology/issues/32408”^^anyURI
Tim9-Tim10 complex created by “ai4c-agent”
Tim9-Tim10 complex creation date “2026-08-07T16:51:54Z”
Tim9-Tim10 complex has_exact_synonym “TIM9-10 complex”
Tim9-Tim10 complex has_obo_namespace “cellular_component”
Tim9-Tim10 complex id “GO:7770105”
Tim9-Tim10 complex definition “A chaperone complex located in the mitochondrial intermembrane space, composed of the small TIM proteins Tim9 and Tim10.”
- database_cross_reference “PMID:16387659”
- database_cross_reference “PMID:33355130”
Tim9-Tim10 complex label “Tim9-Tim10 complex”
Tim9-Tim10 complex SubClassOf mitochondrial intermembrane space chaperone complex

U2 snRNA (adenine-N6)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0106348`

Added

U2 snRNA (adenine-N6)-methyltransferase activity SubClassOf RNA (adenine-N6)-methyltransferase activity

U6 snRNA (adenine(43)-N6)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0120048`

Added

U6 snRNA (adenine(43)-N6)-methyltransferase activity SubClassOf RNA (adenine-N6)-methyltransferase activity

alcohol dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0004022`

Removed

alcohol dehydrogenase (NAD+) activity database_cross_reference “RHEA:12785”
alcohol dehydrogenase (NAD+) activity narrowMatch 12785

aldose reductase [NAD(P)H] activity `http://purl.obolibrary.org/obo/GO_0004032`

Removed

aldose reductase [NAD(P)H] activity has_exact_synonym “alditol:NADP+ 1-oxidoreductase activity”
aldose reductase [NAD(P)H] activity broadMatch ALDEHYDE-REDUCTASE-RXN
aldose reductase [NAD(P)H] activity broadMatch 1.1.1.21
aldose reductase [NAD(P)H] activity exactMatch 12789
aldose reductase [NAD(P)H] activity exactMatch R02820
aldose reductase [NAD(P)H] activity definition “Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.”
- database_cross_reference “EC:1.1.1.21”
aldose reductase [NAD(P)H] activity has_related_synonym “aldose reductase activity”
- database_cross_reference “EC:1.1.1.21”
aldose reductase [NAD(P)H] activity label “aldose reductase (NADPH) activity”
aldose reductase [NAD(P)H] activity SubClassOf alcohol dehydrogenase (NADP+) activity

Added

aldose reductase [NAD(P)H] activity database_cross_reference “EC:1.1.1.21”
aldose reductase [NAD(P)H] activity database_cross_reference “MetaCyc:ALDEHYDE-REDUCTASE-RXN”
aldose reductase [NAD(P)H] activity database_cross_reference “RHEA:12785”
aldose reductase [NAD(P)H] activity has_narrow_synonym “alditol:NADP+ 1-oxidoreductase activity”
aldose reductase [NAD(P)H] activity has_narrow_synonym “aldose reductase (NADPH) activity”
aldose reductase [NAD(P)H] activity exactMatch ALDEHYDE-REDUCTASE-RXN
aldose reductase [NAD(P)H] activity exactMatch 1.1.1.21
aldose reductase [NAD(P)H] activity narrowMatch 12785
aldose reductase [NAD(P)H] activity narrowMatch 12789
aldose reductase [NAD(P)H] activity narrowMatch R02820
aldose reductase [NAD(P)H] activity definition “Catalysis of the reaction: an alditol + NAD(P)+ = an aldose + NAD(P)H + H+.”
- database_cross_reference “EC:1.1.1.21”
aldose reductase [NAD(P)H] activity has_exact_synonym “alditol:NAD(P)+ 1-oxidoreductase activity”
- database_cross_reference “EC:1.1.1.21”
aldose reductase [NAD(P)H] activity has_exact_synonym “aldose reductase activity”
- database_cross_reference “EC:1.1.1.21”
aldose reductase [NAD(P)H] activity label “aldose reductase [NAD(P)H] activity”
aldose reductase [NAD(P)H] activity SubClassOf alcohol dehydrogenase [NAD(P)+] activity

ammonia assimilation cycle `http://purl.obolibrary.org/obo/GO_0019676`

Added

ammonia assimilation cycle term tracker item “https://github.com/geneontology/go-ontology/issues/32376”^^anyURI
ammonia assimilation cycle SubClassOf nutrient assimilation

antennal development `http://purl.obolibrary.org/obo/GO_0007469`

Removed

antennal development definition “The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli.”
- database_cross_reference “http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004526”

Added

antennal development term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
antennal development definition “The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli.”
- database_cross_reference “FBbt:00004511”

anterior compartment pattern formation `http://purl.obolibrary.org/obo/GO_0007387`

Removed

anterior compartment pattern formation definition “The process giving rise to specification of cell identity in the anterior compartments of the segmented embryo.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

anterior compartment pattern formation term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
anterior compartment pattern formation definition “The process giving rise to specification of cell identity in the anterior compartments of the segmented embryo.”
- database_cross_reference “ISBN:0879694238”

anterior region determination `http://purl.obolibrary.org/obo/GO_0007355`

Removed

anterior region determination definition “Specification of the anterior (head and thoracic segments) of the embryo by the gap genes; exemplified in insects by the actions of hunchback gene product.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

anterior region determination term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
anterior region determination definition “Specification of the anterior (head and thoracic segments) of the embryo by the gap genes; exemplified in insects by the actions of hunchback gene product.”
- database_cross_reference “ISBN:0879694238”

anterior/posterior axis specification, embryo `http://purl.obolibrary.org/obo/GO_0008595`

Removed

anterior/posterior axis specification, embryo definition “The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

anterior/posterior axis specification, embryo definition “The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote.”
- database_cross_reference “ISBN:0879694238”

autophagy cargo adaptor activity `http://purl.obolibrary.org/obo/GO_0160247`

Removed

autophagy cargo adaptor activity SubClassOf part of some obsolete substrate localization to autophagosome

Added

autophagy cargo adaptor activity SubClassOf part of some macroautophagy

binding `http://purl.obolibrary.org/obo/GO_0005488`

Added

binding term tracker item “https://github.com/geneontology/go-ontology/issues/32294”^^anyURI
binding in_subset gocheck_do_not_annotate

bipolar cell growth `http://purl.obolibrary.org/obo/GO_0042815`

Removed

bipolar cell growth comment “Bipolar cell growth refers to a change in both cell size and cell shape. For shape changes where cell size is not affected, consider instead the term ‘establishment or maintenance of bipolar cell polarity resulting in cell shape ; GO:0061246’ and its children.”

Added

bipolar cell growth comment “Bipolar cell growth refers to a change in both cell size and cell shape. For shape changes where cell size is not affected, consider instead the term ‘establishment or maintenance of bipolar cell polarity; GO:0061245’ and its children.”

blastoderm segmentation `http://purl.obolibrary.org/obo/GO_0007350`

Removed

blastoderm segmentation definition “The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

blastoderm segmentation term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
blastoderm segmentation definition “The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo.”
- database_cross_reference “ISBN:0879694238”

carboxylic acid biosynthetic process `http://purl.obolibrary.org/obo/GO_0046394`

Added

carboxylic acid biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/32294”^^anyURI
carboxylic acid biosynthetic process in_subset gocheck_do_not_annotate

carboxylic acid catabolic process `http://purl.obolibrary.org/obo/GO_0046395`

Added

carboxylic acid catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/32294”^^anyURI
carboxylic acid catabolic process in_subset gocheck_do_not_annotate

cellular response to interleukin-5 `http://purl.obolibrary.org/obo/GO_7770103`

Added

Class: cellular response to interleukin-5
cellular response to interleukin-5 term tracker item “https://github.com/geneontology/go-ontology/issues/32411”^^anyURI
cellular response to interleukin-5 created by “ai4c-agent”
cellular response to interleukin-5 creation date “2026-08-04T23:16:15Z”
cellular response to interleukin-5 has_exact_synonym “cellular response to IL-5”
cellular response to interleukin-5 has_obo_namespace “biological_process”
cellular response to interleukin-5 id “GO:7770103”
cellular response to interleukin-5 definition “Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-5 stimulus.”
- database_cross_reference “PMID:41207640”
cellular response to interleukin-5 label “cellular response to interleukin-5”
cellular response to interleukin-5 SubClassOf cellular response to cytokine stimulus
cellular response to interleukin-5 SubClassOf response to interleukin-5

citrate-malate shuttle `http://purl.obolibrary.org/obo/GO_7770108`

Added

Class: citrate-malate shuttle
citrate-malate shuttle term tracker item “https://github.com/geneontology/go-ontology/issues/32353”^^anyURI
citrate-malate shuttle created by “ai4c-agent”
citrate-malate shuttle creation date “2026-08-12T10:08:31Z”
citrate-malate shuttle database_cross_reference “Wikipedia:Citrate-malate_shuttle”
citrate-malate shuttle has_exact_synonym “citrate-malate cycle”
citrate-malate shuttle has_exact_synonym “malate-citrate shuttle”
citrate-malate shuttle has_narrow_synonym “acetyl-CoA biosynthesis from citrate”
citrate-malate shuttle has_obo_namespace “biological_process”
citrate-malate shuttle has_related_synonym “non-canonical TCA cycle”
citrate-malate shuttle id “GO:7770108”
citrate-malate shuttle definition “The process of transferring acetyl-CoA from the mitochondrion to the cytosol via citrate. Acetyl-CoA and oxaloacetate produced in the mitochondrion are condensed to citrate by citrate synthase; the citrate is exported to the cytosol by the mitochondrial citrate/malate antiporter in exchange for malate; in the cytosol, ATP citrate lyase cleaves the citrate back to acetyl-CoA and oxaloacetate; the oxaloacetate is then reduced to malate by cytosolic malate dehydrogenase, and the malate is imported back into the mitochondrion to complete the cycle.”
- database_cross_reference “PMID:32414018”
- database_cross_reference “PMID:35264789”
citrate-malate shuttle label “citrate-malate shuttle”
citrate-malate shuttle EquivalentTo metabolic process and (has part some ATP citrate synthase activity) and (has part some L-malate dehydrogenase (NAD+) activity)
citrate-malate shuttle SubClassOf acetyl-CoA metabolic process
citrate-malate shuttle SubClassOf citrate metabolic process
citrate-malate shuttle SubClassOf has part some ATP citrate synthase activity
citrate-malate shuttle SubClassOf has part some mitochondrial citrate transmembrane transport
citrate-malate shuttle SubClassOf has part some L-malate dehydrogenase (NAD+) activity

compartment pattern specification `http://purl.obolibrary.org/obo/GO_0007386`

Removed

compartment pattern specification definition “The regionalization process in which embryonic segments are divided into compartments that will result in differences in cell differentiation.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

compartment pattern specification term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
compartment pattern specification definition “The regionalization process in which embryonic segments are divided into compartments that will result in differences in cell differentiation.”
- database_cross_reference “ISBN:0879694238”

creatine metabolic process `http://purl.obolibrary.org/obo/GO_0006600`

Added

creatine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/32279”^^anyURI

cyclic ADP-ribose hydrolase activity `http://purl.obolibrary.org/obo/GO_0061812`

Removed

cyclic ADP-ribose hydrolase activity term replaced by NAD+ nucleosidase activity, cyclic ADP-ribose generating
cyclic ADP-ribose hydrolase activity definition “OBSOLETE. Catalysis of the reaction: cyclic ADP-ribose + H20 = ADP-ribose (ADPR).”
- database_cross_reference “GOC:dph”
- database_cross_reference “PMID:11866528”
- database_cross_reference “GOC:PARL”
- database_cross_reference “GOC:pad”
cyclic ADP-ribose hydrolase activity deprecated true
cyclic ADP-ribose hydrolase activity comment “This term was obsoleted because it represents a step in a multi-step reaction.”
cyclic ADP-ribose hydrolase activity label “obsolete cyclic ADP-ribose hydrolase”

Added

cyclic ADP-ribose hydrolase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32457”^^anyURI
cyclic ADP-ribose hydrolase activity database_cross_reference “RHEA:38615”
cyclic ADP-ribose hydrolase activity has_exact_synonym “cADPR hydrolase activity”
cyclic ADP-ribose hydrolase activity exactMatch 38615
cyclic ADP-ribose hydrolase activity definition “Catalysis of the reaction: cyclic ADP-beta-D-ribose + H2O = ADP-D-ribose.”
- database_cross_reference “PMID:42243876”
- database_cross_reference “RHEA:38615”
cyclic ADP-ribose hydrolase activity comment “Note that this term was reinstated from obsolete.”
cyclic ADP-ribose hydrolase activity label “cyclic ADP-ribose hydrolase activity”
cyclic ADP-ribose hydrolase activity SubClassOf hydrolase activity, hydrolyzing N-glycosyl compounds

cytoplasm protein quality control `http://purl.obolibrary.org/obo/GO_0140455`

Removed

cytoplasm protein quality control definition “The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are either targeted to cytoplasmic proteasomes for degradation or protected by chaperones to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding.”
- database_cross_reference “PMID:32075773”

Added

cytoplasm protein quality control term tracker item “https://github.com/geneontology/go-ontology/issues/32442”^^anyURI
cytoplasm protein quality control definition “The chemical reactions and pathways resulting in the breakdown or refolding of misfolded proteins in the cytoplasm, which are either targeted to cytoplasmic proteasomes for degradation or protected by chaperones to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding.”
- database_cross_reference “PMID:32075773”

dissimilatory sulfate reduction `http://purl.obolibrary.org/obo/GO_0019420`

Removed

dissimilatory sulfate reduction SubClassOf sulfate assimilation

Added

dissimilatory sulfate reduction SubClassOf sulfur compound metabolic process

ent-kaurene biosynthetic process `http://purl.obolibrary.org/obo/GO_0033332`

Removed

ent-kaurene biosynthetic process SubClassOf obsolete ent-kaurene metabolic process

exit from cytosolic ribosome hibernation `http://purl.obolibrary.org/obo/GO_7770110`

Added

Class: exit from cytosolic ribosome hibernation
exit from cytosolic ribosome hibernation term tracker item “https://github.com/geneontology/go-ontology/issues/32461”^^anyURI
exit from cytosolic ribosome hibernation created by “ai4c-agent”
exit from cytosolic ribosome hibernation creation date “2026-08-14T22:52:06Z”
exit from cytosolic ribosome hibernation has_exact_synonym “ribosome hibernation exit”
exit from cytosolic ribosome hibernation has_exact_synonym “translational restart after ribosome hibernation”
exit from cytosolic ribosome hibernation has_obo_namespace “biological_process”
exit from cytosolic ribosome hibernation has_related_synonym “ribosome reactivation”
exit from cytosolic ribosome hibernation id “GO:7770110”
exit from cytosolic ribosome hibernation definition “A cellular process that results in the reactivation of hibernating cytosolic ribosomes, enabling them to resume translation. Upon reversal of unfavorable conditions such as nutrient limitation, dedicated molecular machinery reactivates hibernating ribosomes and promotes recovery of active translation.”
- database_cross_reference “PMID:32687489”
- database_cross_reference “PMID:42129552”
exit from cytosolic ribosome hibernation label “exit from cytosolic ribosome hibernation”
exit from cytosolic ribosome hibernation SubClassOf positive regulation of cytoplasmic translation

folate cycle `http://purl.obolibrary.org/obo/GO_0035999`

Removed

folate cycle has_exact_synonym “folate cycle”
folate cycle definition “The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesize other tetrahydrofolate molecules.”
- database_cross_reference “GOC:yaf”
- database_cross_reference “PMID:1825999”
folate cycle label “tetrahydrofolate interconversion”

Added

folate cycle term tracker item “https://github.com/geneontology/go-ontology/issues/32362”^^anyURI
folate cycle has_exact_synonym “folate-mediated one-carbon metabolism”
folate cycle has_exact_synonym “folic acid cycle”
folate cycle has_exact_synonym “tetrahydrofolate interconversion”
folate cycle definition “A cyclic series of interconversions of the one-carbon unit carried by tetrahydrofolate - as 10-formyltetrahydrofolate, 5,10-methenyltetrahydrofolate, 5,10-methylenetetrahydrofolate and 5-methyltetrahydrofolate. Couples the acquisition of a one-carbon unit from donors such as serine, glycine or formate with its transfer, in the appropriate oxidation state, to biosynthetic acceptors, and with regeneration of tetrahydrofolate.”
- database_cross_reference “PMID:18804690”
- database_cross_reference “PMID:27641100”
- database_cross_reference “PMID:1825999”
folate cycle label “folate cycle”

formaldehyde assimilation `http://purl.obolibrary.org/obo/GO_0019649`

Added

formaldehyde assimilation SubClassOf nutrient assimilation

fructose export from vacuole to cytosol `http://purl.obolibrary.org/obo/GO_1902334`

Removed

fructose export from vacuole to cytosol label “fructose export from vacuole to cytoplasm”

Added

fructose export from vacuole to cytosol term tracker item “https://github.com/geneontology/go-ontology/issues/32419”^^anyURI
fructose export from vacuole to cytosol label “fructose export from vacuole to cytosol”

ganglioside metabolic process `http://purl.obolibrary.org/obo/GO_0001573`

Added

ganglioside metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/32322”^^anyURI

gap endonuclease activity `http://purl.obolibrary.org/obo/GO_0170076`

Added

Class: gap endonuclease activity
gap endonuclease activity term tracker item “https://github.com/geneontology/go-ontology/issues/32367”^^anyURI
gap endonuclease activity created by “ew”
gap endonuclease activity creation date “2026-08-10T17:51:18Z”
gap endonuclease activity has_exact_synonym “GEN activity”
gap endonuclease activity has_exact_synonym “Gap specific endonuclease activity”
gap endonuclease activity has_obo_namespace “molecular_function”
gap endonuclease activity id “GO:0170076”
gap endonuclease activity definition “Specific recognition and catalysis of the internal cleavage of the phosphodiester backbone within single-stranded DNA gaps or looped DNA structures at the junctions of single-stranded and double-stranded DNA. Primarily involved in the resolution of triplet repeat sequences, removal of aberrant secondary structures formed during the maturation of Okazaki fragments, telomeric R-loop resolution and the processing of stalled replication forks, that all involve cleavage at internal or branched DNA structures.”
- database_cross_reference “PMID:15592449”
- database_cross_reference “PMID:10330154”
gap endonuclease activity label “gap endonuclease activity”
gap endonuclease activity SubClassOf DNA endonuclease activity

glutaredoxin-dependent peroxiredoxin activity `http://purl.obolibrary.org/obo/GO_7770099`

Added

Class: glutaredoxin-dependent peroxiredoxin activity
glutaredoxin-dependent peroxiredoxin activity term tracker item “https://github.com/geneontology/go-ontology/issues/32405”^^anyURI
glutaredoxin-dependent peroxiredoxin activity created by “ai4c-agent”
glutaredoxin-dependent peroxiredoxin activity creation date “2026-08-04T17:43:33Z”
glutaredoxin-dependent peroxiredoxin activity database_cross_reference “EC:1.11.1.25”
glutaredoxin-dependent peroxiredoxin activity database_cross_reference “RHEA:62624”
glutaredoxin-dependent peroxiredoxin activity has_exact_synonym “GrxPx activity”
glutaredoxin-dependent peroxiredoxin activity has_obo_namespace “molecular_function”
glutaredoxin-dependent peroxiredoxin activity has_related_synonym “thiol peroxidase activity”
glutaredoxin-dependent peroxiredoxin activity id “GO:7770099”
glutaredoxin-dependent peroxiredoxin activity exactMatch 1.11.1.25
glutaredoxin-dependent peroxiredoxin activity exactMatch 62624
glutaredoxin-dependent peroxiredoxin activity definition “Catalysis of the reaction: [glutaredoxin]-dithiol + a hydroperoxide = [glutaredoxin]-disulfide + an alcohol + H2O.”
- database_cross_reference “RHEA:62624”
- database_cross_reference “PMID:12517450”
- database_cross_reference “PMID:11832487”
glutaredoxin-dependent peroxiredoxin activity label “glutaredoxin-dependent peroxiredoxin activity”
glutaredoxin-dependent peroxiredoxin activity SubClassOf peroxiredoxin activity

glutathione-dependent peroxiredoxin activity `http://purl.obolibrary.org/obo/GO_7770101`

Added

Class: glutathione-dependent peroxiredoxin activity
glutathione-dependent peroxiredoxin activity term tracker item “https://github.com/geneontology/go-ontology/issues/32405”^^anyURI
glutathione-dependent peroxiredoxin activity created by “ai4c-agent”
glutathione-dependent peroxiredoxin activity creation date “2026-08-04T17:43:33Z”
glutathione-dependent peroxiredoxin activity database_cross_reference “EC:1.11.1.27”
glutathione-dependent peroxiredoxin activity database_cross_reference “RHEA:62632”
glutathione-dependent peroxiredoxin activity database_cross_reference “RHEA:69412”
glutathione-dependent peroxiredoxin activity database_cross_reference “RHEA:69651”
glutathione-dependent peroxiredoxin activity database_cross_reference “RHEA:76731”
glutathione-dependent peroxiredoxin activity has_obo_namespace “molecular_function”
glutathione-dependent peroxiredoxin activity has_related_synonym “thiol peroxidase activity”
glutathione-dependent peroxiredoxin activity id “GO:7770101”
glutathione-dependent peroxiredoxin activity exactMatch 1.11.1.27
glutathione-dependent peroxiredoxin activity exactMatch 62632
glutathione-dependent peroxiredoxin activity narrowMatch 69412
glutathione-dependent peroxiredoxin activity narrowMatch 69651
glutathione-dependent peroxiredoxin activity narrowMatch 76731
glutathione-dependent peroxiredoxin activity definition “Catalysis of the reaction: a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.”
- database_cross_reference “RHEA:62632”
- database_cross_reference “PMID:15004285”
- database_cross_reference “PMID:12606554”
glutathione-dependent peroxiredoxin activity label “glutathione-dependent peroxiredoxin activity”
glutathione-dependent peroxiredoxin activity SubClassOf peroxidase activity

glycine decarboxylation via glycine cleavage system `http://purl.obolibrary.org/obo/GO_0019464`

Removed

glycine decarboxylation via glycine cleavage system definition “The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex.”
- database_cross_reference “MetaCyc:GLYCLEAV-PWY”

Added

glycine decarboxylation via glycine cleavage system term tracker item “https://github.com/geneontology/go-ontology/issues/32362”^^anyURI
glycine decarboxylation via glycine cleavage system definition “The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex.”
- database_cross_reference “PMID:41521798”
- database_cross_reference “MetaCyc:GLYCLEAV-PWY”
- database_cross_reference “PMID:36347252”

granulocyte colony-stimulating factor signaling pathway `http://purl.obolibrary.org/obo/GO_0038158`

Added

granulocyte colony-stimulating factor signaling pathway term tracker item “https://github.com/geneontology/go-ontology/issues/32373”^^anyURI

group translocator activity `http://purl.obolibrary.org/obo/GO_7770111`

Added

Class: group translocator activity
group translocator activity term tracker item “https://github.com/geneontology/go-ontology/issues/27496”^^anyURI
group translocator activity created by “ai4c-agent”
group translocator activity creation date “2026-08-18T00:41:26Z”
group translocator activity database_cross_reference “TC:4”
group translocator activity has_exact_synonym “group translocation activity”
group translocator activity has_obo_namespace “molecular_function”
group translocator activity has_related_synonym “group translocator”
group translocator activity id “GO:7770111”
group translocator activity definition “Enables the transfer of a substance from one side of a membrane to the other, where the substance is chemically modified as an integral part of the translocation process, so that the species released on the far side of the membrane is not the species that was bound on the near side. This differs from primary and secondary active transport, in which the transported substance is unchanged.”
- database_cross_reference “PMID:31214989”
- database_cross_reference “PMID:33170213”
group translocator activity label “group translocator activity”
group translocator activity SubClassOf transmembrane transporter activity
group translocator activity SubClassOf has part some catalytic activity

heme export from vacuole to cytosol `http://purl.obolibrary.org/obo/GO_0140357`

Removed

heme export from vacuole to cytosol label “heme export from vacuole to cytoplasm”

Added

heme export from vacuole to cytosol term tracker item “https://github.com/geneontology/go-ontology/issues/32419”^^anyURI
heme export from vacuole to cytosol label “heme export from vacuole to cytosol”

interleukin-5-mediated signaling pathway `http://purl.obolibrary.org/obo/GO_0038043`

Added

interleukin-5-mediated signaling pathway SubClassOf part of some cellular response to interleukin-5

intracellular organelle lumen `http://purl.obolibrary.org/obo/GO_0070013`

Added

intracellular organelle lumen term tracker item “https://github.com/geneontology/go-ontology/issues/32294”^^anyURI
intracellular organelle lumen in_subset gocheck_do_not_annotate

inward rectifier potassium channel inhibitor activity `http://purl.obolibrary.org/obo/GO_0070320`

Removed

inward rectifier potassium channel inhibitor activity SubClassOf potassium channel inhibitor activity

Added

inward rectifier potassium channel inhibitor activity SubClassOf voltage-gated potassium channel inhibitor activity

large conductance calcium-activated potassium channel inhibitor activity `http://purl.obolibrary.org/obo/GO_7770089`

Added

Class: large conductance calcium-activated potassium channel inhibitor activity
large conductance calcium-activated potassium channel inhibitor activity term tracker item “https://github.com/geneontology/go-ontology/issues/32358”^^anyURI
large conductance calcium-activated potassium channel inhibitor activity created by “ai4c-agent”
large conductance calcium-activated potassium channel inhibitor activity creation date “2026-07-28T00:46:41Z”
large conductance calcium-activated potassium channel inhibitor activity has_exact_synonym “BK KCa channel inhibitor activity”
large conductance calcium-activated potassium channel inhibitor activity has_exact_synonym “BK calcium-activated potassium channel inhibitor activity”
large conductance calcium-activated potassium channel inhibitor activity has_exact_synonym “large conductance KCa channel inhibitor activity”
large conductance calcium-activated potassium channel inhibitor activity has_obo_namespace “molecular_function”
large conductance calcium-activated potassium channel inhibitor activity has_related_synonym “BK channel inhibitor activity”
large conductance calcium-activated potassium channel inhibitor activity id “GO:7770089”
large conductance calcium-activated potassium channel inhibitor activity definition “Binds to and stops, prevents, or reduces the activity of a large conductance calcium-activated potassium channel.”
- database_cross_reference “PMID:39971906”
- database_cross_reference “PMID:17591990”
large conductance calcium-activated potassium channel inhibitor activity label “large conductance calcium-activated potassium channel inhibitor activity”
large conductance calcium-activated potassium channel inhibitor activity SubClassOf potassium channel inhibitor activity
large conductance calcium-activated potassium channel inhibitor activity SubClassOf negatively regulates some large conductance calcium-activated potassium channel activity

lipoyl-GcvH:protein N-lipoyltransferase activity `http://purl.obolibrary.org/obo/GO_7770091`

Added

Class: lipoyl-GcvH:protein N-lipoyltransferase activity
lipoyl-GcvH:protein N-lipoyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32361”^^anyURI
lipoyl-GcvH:protein N-lipoyltransferase activity created by “ai4c-agent”
lipoyl-GcvH:protein N-lipoyltransferase activity creation date “2026-07-28T20:08:06Z”
lipoyl-GcvH:protein N-lipoyltransferase activity has_broad_synonym “lipoyl amidotransferase activity”
lipoyl-GcvH:protein N-lipoyltransferase activity database_cross_reference “EC:2.3.1.204”
lipoyl-GcvH:protein N-lipoyltransferase activity database_cross_reference “RHEA:16413”
lipoyl-GcvH:protein N-lipoyltransferase activity database_cross_reference “RHEA:20213”
lipoyl-GcvH:protein N-lipoyltransferase activity has_obo_namespace “molecular_function”
lipoyl-GcvH:protein N-lipoyltransferase activity has_related_synonym “lipoyl relay activity”
lipoyl-GcvH:protein N-lipoyltransferase activity has_related_synonym “octanoyl-[GcvH]:protein N-octanoyltransferase activity”
lipoyl-GcvH:protein N-lipoyltransferase activity id “GO:7770091”
lipoyl-GcvH:protein N-lipoyltransferase activity exactMatch 2.3.1.204
lipoyl-GcvH:protein N-lipoyltransferase activity narrowMatch 16413
lipoyl-GcvH:protein N-lipoyltransferase activity narrowMatch 20213
lipoyl-GcvH:protein N-lipoyltransferase activity definition “Catalysis of the reaction: N6-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + L-lysyl-[lipoyl-carrier protein] = L-lysyl-[glycine-cleavage complex H protein] + N6-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein].”
- database_cross_reference “PMID:38624243”
- database_cross_reference “EC:2.3.1.204”
lipoyl-GcvH:protein N-lipoyltransferase activity comment “The enzyme also transfers the biosynthetic precursor octanoyl group, and relays the acyl group from GcvH onto the E2 subunits of the pyruvate, 2-oxoglutarate, branched-chain 2-oxoacid and acetoin dehydrogenase complexes.”
lipoyl-GcvH:protein N-lipoyltransferase activity label “lipoyl-GcvH:protein N-lipoyltransferase activity”
lipoyl-GcvH:protein N-lipoyltransferase activity SubClassOf acyltransferase activity, transferring groups other than amino-acyl groups
lipoyl-GcvH:protein N-lipoyltransferase activity SubClassOf catalytic activity, acting on a protein

mRNA m(6)A methyltransferase activity `http://purl.obolibrary.org/obo/GO_0001734`

Added

mRNA m(6)A methyltransferase activity SubClassOf RNA (adenine-N6)-methyltransferase activity

maternal determination of anterior/posterior axis, embryo `http://purl.obolibrary.org/obo/GO_0008358`

Removed

maternal determination of anterior/posterior axis, embryo definition “The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

maternal determination of anterior/posterior axis, embryo term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
maternal determination of anterior/posterior axis, embryo definition “The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos.”
- database_cross_reference “ISBN:0879694238”

membrane insertase activity `http://purl.obolibrary.org/obo/GO_0032977`

Removed

membrane insertase activity SubClassOf part of some establishment of protein localization to membrane

Added

membrane insertase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32404”^^anyURI

mitochondrial intermembrane space chaperone complex `http://purl.obolibrary.org/obo/GO_0042719`

Removed

mitochondrial intermembrane space chaperone complex has_narrow_synonym “Tim8-Tim13 complex”
mitochondrial intermembrane space chaperone complex has_narrow_synonym “Tim9-Tim10 complex”

Added

mitochondrial intermembrane space chaperone complex term tracker item “https://github.com/geneontology/go-ontology/issues/32408”^^anyURI

mitochondrial membrane organization `http://purl.obolibrary.org/obo/GO_0007006`

Removed

mitochondrial membrane organization EquivalentTo membrane organization and (occurs in some mitochondrion)
mitochondrial membrane organization SubClassOf mitochondrion organization
mitochondrial membrane organization SubClassOf occurs in some mitochondrion

Added

mitochondrial membrane organization term tracker item “https://github.com/geneontology/go-ontology/issues/32356”^^anyURI
mitochondrial membrane organization SubClassOf part of some mitochondrion organization

mitochondrial protein quality control `http://purl.obolibrary.org/obo/GO_0141164`

Added

mitochondrial protein quality control SubClassOf protein catabolic process

momilactone-A synthase [NAD(P)H] activity `http://purl.obolibrary.org/obo/GO_0102960`

Removed

momilactone-A synthase [NAD(P)H] activity exactMatch 25363

mycoredoxin-dependent peroxiredoxin activity `http://purl.obolibrary.org/obo/GO_7770100`

Added

Class: mycoredoxin-dependent peroxiredoxin activity
mycoredoxin-dependent peroxiredoxin activity term tracker item “https://github.com/geneontology/go-ontology/issues/32405”^^anyURI
mycoredoxin-dependent peroxiredoxin activity created by “ai4c-agent”
mycoredoxin-dependent peroxiredoxin activity creation date “2026-08-04T17:43:33Z”
mycoredoxin-dependent peroxiredoxin activity database_cross_reference “EC:1.11.1.29”
mycoredoxin-dependent peroxiredoxin activity database_cross_reference “RHEA:62640”
mycoredoxin-dependent peroxiredoxin activity has_obo_namespace “molecular_function”
mycoredoxin-dependent peroxiredoxin activity has_related_synonym “thiol peroxidase activity”
mycoredoxin-dependent peroxiredoxin activity id “GO:7770100”
mycoredoxin-dependent peroxiredoxin activity exactMatch 1.11.1.29
mycoredoxin-dependent peroxiredoxin activity exactMatch 62640
mycoredoxin-dependent peroxiredoxin activity definition “Catalysis of the reaction: [mycoredoxin]-dithiol + a hydroperoxide = [mycoredoxin]-disulfide + an alcohol + H2O.”
- database_cross_reference “RHEA:62640”
- database_cross_reference “PMID:19737009”
- database_cross_reference “PMID:24379404”
mycoredoxin-dependent peroxiredoxin activity label “mycoredoxin-dependent peroxiredoxin activity”
mycoredoxin-dependent peroxiredoxin activity SubClassOf peroxiredoxin activity

myo-inositol export across plasma membrane `http://purl.obolibrary.org/obo/GO_7770109`

Added

Class: myo-inositol export across plasma membrane
myo-inositol export across plasma membrane term tracker item “https://github.com/geneontology/go-ontology/issues/32460”^^anyURI
myo-inositol export across plasma membrane created by “ai4c-agent”
myo-inositol export across plasma membrane creation date “2026-08-14T19:33:20Z”
myo-inositol export across plasma membrane has_broad_synonym “inositol export”
myo-inositol export across plasma membrane has_broad_synonym “myo-inositol export”
myo-inositol export across plasma membrane has_exact_synonym “myo-inositol export from cell”
myo-inositol export across plasma membrane has_obo_namespace “biological_process”
myo-inositol export across plasma membrane id “GO:7770109”
myo-inositol export across plasma membrane definition “The directed movement of myo-inositol from inside of a cell, across the plasma membrane and into the extracellular region.”
- database_cross_reference “PMID:42567923”
myo-inositol export across plasma membrane label “myo-inositol export across plasma membrane”
myo-inositol export across plasma membrane SubClassOf polyol transmembrane transport
myo-inositol export across plasma membrane SubClassOf myo-inositol transport
myo-inositol export across plasma membrane SubClassOf export across plasma membrane

negative regulation of coenzyme A biosynthetic process `http://purl.obolibrary.org/obo/GO_0170077`

Added

Class: negative regulation of coenzyme A biosynthetic process
negative regulation of coenzyme A biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/32390”^^anyURI
negative regulation of coenzyme A biosynthetic process created by “ew”
negative regulation of coenzyme A biosynthetic process creation date “2026-08-10T18:46:59Z”
negative regulation of coenzyme A biosynthetic process has_obo_namespace “biological_process”
negative regulation of coenzyme A biosynthetic process id “GO:0170077”
negative regulation of coenzyme A biosynthetic process definition “Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of coenzyme A.”
- database_cross_reference “PMID:42000723”
negative regulation of coenzyme A biosynthetic process label “negative regulation of coenzyme A biosynthetic process”
negative regulation of coenzyme A biosynthetic process SubClassOf regulation of coenzyme A biosynthetic process

negative regulation of cristae formation `http://purl.obolibrary.org/obo/GO_1903851`

Removed

negative regulation of cristae formation SubClassOf negative regulation of organelle organization

Added

negative regulation of cristae formation SubClassOf negative regulation of cellular component organization

nitrate assimilation `http://purl.obolibrary.org/obo/GO_0042128`

Added

nitrate assimilation term tracker item “https://github.com/geneontology/go-ontology/issues/32376”^^anyURI
nitrate assimilation SubClassOf nutrient assimilation

nutrient assimilation `http://purl.obolibrary.org/obo/GO_7770097`

Added

Class: nutrient assimilation
nutrient assimilation term tracker item “https://github.com/geneontology/go-ontology/issues/32376”^^anyURI
nutrient assimilation created by “ai4c-agent”
nutrient assimilation creation date “2026-07-29T05:36:39Z”
nutrient assimilation has_exact_synonym “assimilation of nutrients”
nutrient assimilation has_obo_namespace “biological_process”
nutrient assimilation id “GO:7770097”
nutrient assimilation in_subset gocheck_do_not_annotate
nutrient assimilation definition “The chemical reactions and pathways by which a cell or organism takes up a nutrient from its environment and incorporates it into cellular constituents, characteristically converting a simple, usually inorganic, nutrient source such as nitrate, sulfate, ammonia or a one-carbon compound into organic constituents of the cell.”
- database_cross_reference “PMID:34973427”
- database_cross_reference “PMID:22103536”
- database_cross_reference “PMID:27572125”
nutrient assimilation label “nutrient assimilation”
nutrient assimilation SubClassOf metabolic process

obsolete 10-formyltetrahydrofolate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009257`

Removed

obsolete 10-formyltetrahydrofolate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate.”
- database_cross_reference “GOC:ai”
obsolete 10-formyltetrahydrofolate biosynthetic process label “10-formyltetrahydrofolate biosynthetic process”
obsolete 10-formyltetrahydrofolate biosynthetic process SubClassOf 10-formyltetrahydrofolate metabolic process
obsolete 10-formyltetrahydrofolate biosynthetic process SubClassOf dicarboxylic acid biosynthetic process
obsolete 10-formyltetrahydrofolate biosynthetic process SubClassOf tetrahydrofolate biosynthetic process

Added

obsolete 10-formyltetrahydrofolate biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/32289”^^anyURI
obsolete 10-formyltetrahydrofolate biosynthetic process term replaced by folate cycle
obsolete 10-formyltetrahydrofolate biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate.”
- database_cross_reference “GOC:ai”
obsolete 10-formyltetrahydrofolate biosynthetic process deprecated true
obsolete 10-formyltetrahydrofolate biosynthetic process comment “This term was obsoleted because it represents the same process as folate cycle ; GO:0035999.”
obsolete 10-formyltetrahydrofolate biosynthetic process label “obsolete 10-formyltetrahydrofolate biosynthetic process”

obsolete diaminopimelate biosynthetic process `http://purl.obolibrary.org/obo/GO_0019877`

Removed

obsolete diaminopimelate biosynthetic process consider L-leucine biosynthetic process
obsolete diaminopimelate biosynthetic process comment “This term was obsoleted because it represents an intermediate in L-leucine biosynthesis.”

Added

obsolete diaminopimelate biosynthetic process consider L-lysine biosynthetic process
obsolete diaminopimelate biosynthetic process comment “This term was obsoleted because it represents an intermediate in L-lysine biosynthesis.”

obsolete ent-kaurene metabolic process `http://purl.obolibrary.org/obo/GO_0033331`

Removed

obsolete ent-kaurene metabolic process definition “The chemical reactions and pathways involving ent-kaur-16-ene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins.”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:17064690”
obsolete ent-kaurene metabolic process label “ent-kaurene metabolic process”
obsolete ent-kaurene metabolic process SubClassOf terpene metabolic process

Added

obsolete ent-kaurene metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/28120”^^anyURI
obsolete ent-kaurene metabolic process consider ent-kaurene biosynthetic process
obsolete ent-kaurene metabolic process definition “OBSOLETE. The chemical reactions and pathways involving ent-kaur-16-ene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins.”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:17064690”
obsolete ent-kaurene metabolic process deprecated true
obsolete ent-kaurene metabolic process comment “The reason for obsoletion is that this term was an unnecessary grouping term.”
obsolete ent-kaurene metabolic process label “obsolete ent-kaurene metabolic process”

obsolete envenomation resulting in occlusion of the pore of voltage-gated potassium channel `http://purl.obolibrary.org/obo/GO_0044564`

Removed

obsolete envenomation resulting in occlusion of the pore of voltage-gated potassium channel term replaced by obsolete venom-mediated inhibition of voltage-gated potassium channel activity

obsolete envenomation resulting in slowing of activation kinetics of voltage-gated potassium channel `http://purl.obolibrary.org/obo/GO_0044563`

Removed

obsolete envenomation resulting in slowing of activation kinetics of voltage-gated potassium channel term replaced by obsolete venom-mediated inhibition of voltage-gated potassium channel activity

obsolete establishment of central gap gene boundaries `http://purl.obolibrary.org/obo/GO_0007358`

Removed

obsolete establishment of central gap gene boundaries definition “OBSOLETE. Specification of the borders of central gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by knirps repression of Kruppel.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

obsolete establishment of central gap gene boundaries term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
obsolete establishment of central gap gene boundaries definition “OBSOLETE. Specification of the borders of central gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by knirps repression of Kruppel.”
- database_cross_reference “ISBN:0879694238”

obsolete establishment of posterior gap gene boundaries `http://purl.obolibrary.org/obo/GO_0007361`

Removed

obsolete establishment of posterior gap gene boundaries definition “OBSOLETE. Specification of the borders of posterior gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by hunchback and tailless repression of knirps.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

obsolete establishment of posterior gap gene boundaries definition “OBSOLETE. Specification of the borders of posterior gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by hunchback and tailless repression of knirps.”
- database_cross_reference “ISBN:0879694238”

obsolete establishment of terminal gap gene boundary `http://purl.obolibrary.org/obo/GO_0007364`

Removed

obsolete establishment of terminal gap gene boundary definition “OBSOLETE. Specification of the borders of terminal gap gene expression mediated largely by the effects of other gap genes.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

obsolete establishment of terminal gap gene boundary definition “OBSOLETE. Specification of the borders of terminal gap gene expression mediated largely by the effects of other gap genes.”
- database_cross_reference “ISBN:0879694238”

obsolete establishment or maintenance of bipolar cell polarity regulating cell shape `http://purl.obolibrary.org/obo/GO_0061246`

Removed

obsolete establishment or maintenance of bipolar cell polarity regulating cell shape definition “Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns that regulates the shaping of a cell.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:vw”
obsolete establishment or maintenance of bipolar cell polarity regulating cell shape label “establishment or maintenance of bipolar cell polarity regulating cell shape”
obsolete establishment or maintenance of bipolar cell polarity regulating cell shape SubClassOf establishment or maintenance of bipolar cell polarity
obsolete establishment or maintenance of bipolar cell polarity regulating cell shape SubClassOf establishment or maintenance of cell polarity regulating cell shape

Added

obsolete establishment or maintenance of bipolar cell polarity regulating cell shape term tracker item “https://github.com/geneontology/go-ontology/issues/21217”^^anyURI
obsolete establishment or maintenance of bipolar cell polarity regulating cell shape term replaced by establishment or maintenance of bipolar cell polarity
obsolete establishment or maintenance of bipolar cell polarity regulating cell shape definition “OBSOLETE. Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns that regulates the shaping of a cell.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:vw”
obsolete establishment or maintenance of bipolar cell polarity regulating cell shape deprecated true
obsolete establishment or maintenance of bipolar cell polarity regulating cell shape comment “The reason for obsoletion is that this term was made in error.”
obsolete establishment or maintenance of bipolar cell polarity regulating cell shape label “obsolete establishment or maintenance of bipolar cell polarity regulating cell shape”

obsolete macromolecule depalmitoylation `http://purl.obolibrary.org/obo/GO_0098734`

Removed

obsolete macromolecule depalmitoylation definition “The removal of palymitoyl groups from a macromolecule.”
- database_cross_reference “GOC:dos”
obsolete macromolecule depalmitoylation label “macromolecule depalmitoylation”
obsolete macromolecule depalmitoylation SubClassOf macromolecule deacylation

Added

obsolete macromolecule depalmitoylation term tracker item “https://github.com/geneontology/go-ontology/issues/32290”^^anyURI
obsolete macromolecule depalmitoylation consider palmitoyl-(protein) hydrolase activity
obsolete macromolecule depalmitoylation consider palmitoyl hydrolase activity
obsolete macromolecule depalmitoylation definition “OBSOLETE. The removal of palymitoyl groups from a macromolecule.”
- database_cross_reference “GOC:dos”
obsolete macromolecule depalmitoylation deprecated true
obsolete macromolecule depalmitoylation comment “The reason for obsoletion is that this term represents a molecular function, not a biological process. Consider instead annotating to the molecular function ‘palmitoyl hydrolase activity’ (GO:0098599), or, for protein substrates, ‘palmitoyl-(protein) hydrolase activity’ (GO:0008474).”
obsolete macromolecule depalmitoylation label “obsolete macromolecule depalmitoylation”

obsolete maintenance of bipolar cell polarity regulating cell shape `http://purl.obolibrary.org/obo/GO_0061305`

Removed

obsolete maintenance of bipolar cell polarity regulating cell shape definition “The maintenance of established bipolar anisotropic intracellular organization or cell growth patterns that results in the shaping of a cell.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:vw”
obsolete maintenance of bipolar cell polarity regulating cell shape label “maintenance of bipolar cell polarity regulating cell shape”
obsolete maintenance of bipolar cell polarity regulating cell shape SubClassOf obsolete establishment or maintenance of bipolar cell polarity regulating cell shape

Added

obsolete maintenance of bipolar cell polarity regulating cell shape term tracker item “https://github.com/geneontology/go-ontology/issues/21217”^^anyURI
obsolete maintenance of bipolar cell polarity regulating cell shape term replaced by establishment or maintenance of bipolar cell polarity
obsolete maintenance of bipolar cell polarity regulating cell shape definition “OBSOLETE. The maintenance of established bipolar anisotropic intracellular organization or cell growth patterns that results in the shaping of a cell.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:vw”
obsolete maintenance of bipolar cell polarity regulating cell shape deprecated true
obsolete maintenance of bipolar cell polarity regulating cell shape comment “The reason for obsoletion is that these terms were added in error.”
obsolete maintenance of bipolar cell polarity regulating cell shape label “obsolete maintenance of bipolar cell polarity regulating cell shape”

obsolete membrane addition at site of mitotic cytokinesis `http://purl.obolibrary.org/obo/GO_0061796`

Removed

obsolete membrane addition at site of mitotic cytokinesis definition “A mitotic cell cycle process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:vw”
obsolete membrane addition at site of mitotic cytokinesis label “membrane addition at site of mitotic cytokinesis”
obsolete membrane addition at site of mitotic cytokinesis EquivalentTo membrane addition at site of cytokinesis and (part of some mitotic cell cycle)
obsolete membrane addition at site of mitotic cytokinesis SubClassOf membrane addition at site of cytokinesis
obsolete membrane addition at site of mitotic cytokinesis SubClassOf mitotic cytokinetic process

Added

obsolete membrane addition at site of mitotic cytokinesis term tracker item “https://github.com/geneontology/go-ontology/issues/31687”^^anyURI
obsolete membrane addition at site of mitotic cytokinesis consider exocytosis
obsolete membrane addition at site of mitotic cytokinesis definition “OBSOLETE. A mitotic cell cycle process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:vw”
obsolete membrane addition at site of mitotic cytokinesis deprecated true
obsolete membrane addition at site of mitotic cytokinesis comment “The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.”
obsolete membrane addition at site of mitotic cytokinesis label “obsolete membrane addition at site of mitotic cytokinesis”

obsolete mitochondrial protein-transporting ATPase activity `http://purl.obolibrary.org/obo/GO_0008566`

Removed

obsolete mitochondrial protein-transporting ATPase activity definition “Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex.”
- database_cross_reference “EC:7.4.2.3”
obsolete mitochondrial protein-transporting ATPase activity comment “See also the cellular component term ‘mitochondrial inner membrane presequence translocase complex ; GO:0005744’.”
obsolete mitochondrial protein-transporting ATPase activity label “mitochondrial protein-transporting ATPase activity”
obsolete mitochondrial protein-transporting ATPase activity EquivalentTo protein-transporting ATPase activity and (occurs in some mitochondrion)
obsolete mitochondrial protein-transporting ATPase activity SubClassOf protein-transporting ATPase activity
obsolete mitochondrial protein-transporting ATPase activity SubClassOf occurs in some mitochondrion

Added

obsolete mitochondrial protein-transporting ATPase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32393”^^anyURI
obsolete mitochondrial protein-transporting ATPase activity definition “OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex.”
- database_cross_reference “EC:7.4.2.3”
obsolete mitochondrial protein-transporting ATPase activity deprecated true
obsolete mitochondrial protein-transporting ATPase activity comment “The reason for obsoletion is that the term is not clearly defined and usage has been inconsistent.”
obsolete mitochondrial protein-transporting ATPase activity label “obsolete mitochondrial protein-transporting ATPase activity”

obsolete negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape `http://purl.obolibrary.org/obo/GO_2000750`

Removed

obsolete negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape definition “Any process that stops, prevents or reduces the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape.”
- database_cross_reference “GOC:mah”
obsolete negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape label “negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape”
obsolete negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape EquivalentTo biological regulation and (negatively regulates some obsolete establishment or maintenance of bipolar cell polarity regulating cell shape)
obsolete negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape SubClassOf obsolete regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
obsolete negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape SubClassOf negative regulation of establishment or maintenance of cell polarity regulating cell shape
obsolete negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape SubClassOf negatively regulates some obsolete establishment or maintenance of bipolar cell polarity regulating cell shape

Added

obsolete negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape term tracker item “https://github.com/geneontology/go-ontology/issues/21217”^^anyURI
obsolete negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape term replaced by establishment or maintenance of bipolar cell polarity
obsolete negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape definition “OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape.”
- database_cross_reference “GOC:mah”
obsolete negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape deprecated true
obsolete negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape comment “The reason for obsoletion is that this term was made in error.”
obsolete negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape label “obsolete negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape”

obsolete negative regulation of maintenance of bipolar cell polarity regulating cell shape `http://purl.obolibrary.org/obo/GO_0061362`

Removed

obsolete negative regulation of maintenance of bipolar cell polarity regulating cell shape definition “Any process that decreases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape.”
- database_cross_reference “GOC:dph”
obsolete negative regulation of maintenance of bipolar cell polarity regulating cell shape label “negative regulation of maintenance of bipolar cell polarity regulating cell shape”
obsolete negative regulation of maintenance of bipolar cell polarity regulating cell shape SubClassOf obsolete regulation of maintenance of bipolar cell polarity regulating cell shape
obsolete negative regulation of maintenance of bipolar cell polarity regulating cell shape SubClassOf obsolete negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
obsolete negative regulation of maintenance of bipolar cell polarity regulating cell shape SubClassOf negatively regulates some obsolete maintenance of bipolar cell polarity regulating cell shape

Added

obsolete negative regulation of maintenance of bipolar cell polarity regulating cell shape term tracker item “https://github.com/geneontology/go-ontology/issues/21217”^^anyURI
obsolete negative regulation of maintenance of bipolar cell polarity regulating cell shape term replaced by establishment or maintenance of bipolar cell polarity
obsolete negative regulation of maintenance of bipolar cell polarity regulating cell shape definition “OBSOLETE. Any process that decreases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape.”
- database_cross_reference “GOC:dph”
obsolete negative regulation of maintenance of bipolar cell polarity regulating cell shape deprecated true
obsolete negative regulation of maintenance of bipolar cell polarity regulating cell shape comment “The reason for obsoletion is that this term was made in error.”
obsolete negative regulation of maintenance of bipolar cell polarity regulating cell shape label “obsolete negative regulation of maintenance of bipolar cell polarity regulating cell shape”

obsolete ocellus pigment granule organization `http://purl.obolibrary.org/obo/GO_0008058`

Removed

obsolete ocellus pigment granule organization definition “A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the ocellus.”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”
obsolete ocellus pigment granule organization label “ocellus pigment granule organization”
obsolete ocellus pigment granule organization SubClassOf pigment granule organization

Added

obsolete ocellus pigment granule organization term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
obsolete ocellus pigment granule organization definition “OBSOLETE. A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the ocellus.”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”
obsolete ocellus pigment granule organization deprecated true
obsolete ocellus pigment granule organization comment “The reason for obsoletion is that this term was made in error.”
obsolete ocellus pigment granule organization label “obsolete ocellus pigment granule organization”

obsolete positive regulation of establishment of bipolar cell polarity regulating cell shape `http://purl.obolibrary.org/obo/GO_0061161`

Removed

obsolete positive regulation of establishment of bipolar cell polarity regulating cell shape definition “Any process that increases the rate, frequency or extent of the establishment of bipolar cell polarity that regulates the shape of a cell.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:vw”
obsolete positive regulation of establishment of bipolar cell polarity regulating cell shape label “positive regulation of establishment of bipolar cell polarity regulating cell shape”
obsolete positive regulation of establishment of bipolar cell polarity regulating cell shape SubClassOf obsolete regulation of establishment of bipolar cell polarity regulating cell shape
obsolete positive regulation of establishment of bipolar cell polarity regulating cell shape SubClassOf positive regulation of establishment of bipolar cell polarity
obsolete positive regulation of establishment of bipolar cell polarity regulating cell shape SubClassOf obsolete positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape

Added

obsolete positive regulation of establishment of bipolar cell polarity regulating cell shape term tracker item “https://github.com/geneontology/go-ontology/issues/21217”^^anyURI
obsolete positive regulation of establishment of bipolar cell polarity regulating cell shape term replaced by establishment or maintenance of bipolar cell polarity
obsolete positive regulation of establishment of bipolar cell polarity regulating cell shape definition “OBSOLETE. Any process that increases the rate, frequency or extent of the establishment of bipolar cell polarity that regulates the shape of a cell.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:vw”
obsolete positive regulation of establishment of bipolar cell polarity regulating cell shape deprecated true
obsolete positive regulation of establishment of bipolar cell polarity regulating cell shape comment “The reason for obsoletion is that this term was made in error.”
obsolete positive regulation of establishment of bipolar cell polarity regulating cell shape label “obsolete positive regulation of establishment of bipolar cell polarity regulating cell shape”

obsolete positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape `http://purl.obolibrary.org/obo/GO_2000247`

Removed

obsolete positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape definition “Any process that activates or increases the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape.”
- database_cross_reference “GOC:obol”
obsolete positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape label “positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape”
obsolete positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape EquivalentTo biological regulation and (positively regulates some obsolete establishment or maintenance of bipolar cell polarity regulating cell shape)
obsolete positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape SubClassOf obsolete regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
obsolete positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape SubClassOf positive regulation of establishment or maintenance of cell polarity regulating cell shape
obsolete positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape SubClassOf positively regulates some obsolete establishment or maintenance of bipolar cell polarity regulating cell shape

Added

obsolete positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape term tracker item “https://github.com/geneontology/go-ontology/issues/21217”^^anyURI
obsolete positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape term replaced by establishment or maintenance of bipolar cell polarity
obsolete positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape.”
- database_cross_reference “GOC:obol”
obsolete positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape deprecated true
obsolete positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape comment “The reason for obsoletion is that these terms were added in error.”
obsolete positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape label “obsolete positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape”

obsolete positive regulation of maintenance of bipolar cell polarity regulating cell shape `http://purl.obolibrary.org/obo/GO_0061361`

Removed

obsolete positive regulation of maintenance of bipolar cell polarity regulating cell shape definition “Any process that increases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape.”
- database_cross_reference “GOC:dph”
obsolete positive regulation of maintenance of bipolar cell polarity regulating cell shape label “positive regulation of maintenance of bipolar cell polarity regulating cell shape”
obsolete positive regulation of maintenance of bipolar cell polarity regulating cell shape SubClassOf obsolete regulation of maintenance of bipolar cell polarity regulating cell shape
obsolete positive regulation of maintenance of bipolar cell polarity regulating cell shape SubClassOf obsolete positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
obsolete positive regulation of maintenance of bipolar cell polarity regulating cell shape SubClassOf positively regulates some obsolete maintenance of bipolar cell polarity regulating cell shape

Added

obsolete positive regulation of maintenance of bipolar cell polarity regulating cell shape term tracker item “https://github.com/geneontology/go-ontology/issues/21217”^^anyURI
obsolete positive regulation of maintenance of bipolar cell polarity regulating cell shape term replaced by establishment or maintenance of bipolar cell polarity
obsolete positive regulation of maintenance of bipolar cell polarity regulating cell shape definition “OBSOLETE. Any process that increases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape.”
- database_cross_reference “GOC:dph”
obsolete positive regulation of maintenance of bipolar cell polarity regulating cell shape deprecated true
obsolete positive regulation of maintenance of bipolar cell polarity regulating cell shape comment “The reason for obsoletion is that this term was made in error.”
obsolete positive regulation of maintenance of bipolar cell polarity regulating cell shape label “obsolete positive regulation of maintenance of bipolar cell polarity regulating cell shape”

obsolete protein depalmitoylation `http://purl.obolibrary.org/obo/GO_0002084`

Removed

obsolete protein depalmitoylation in_subset gocheck_obsoletion_candidate
obsolete protein depalmitoylation definition “The removal of palymitoyl groups from a lipoprotein.”
- database_cross_reference “GOC:hjd”
obsolete protein depalmitoylation label “protein depalmitoylation”
obsolete protein depalmitoylation SubClassOf protein deacylation
obsolete protein depalmitoylation SubClassOf lipoprotein catabolic process
obsolete protein depalmitoylation SubClassOf obsolete macromolecule depalmitoylation

Added

obsolete protein depalmitoylation term tracker item “https://github.com/geneontology/go-ontology/issues/32290”^^anyURI
obsolete protein depalmitoylation consider palmitoyl-(protein) hydrolase activity
obsolete protein depalmitoylation definition “OBSOLETE. The removal of palymitoyl groups from a lipoprotein.”
- database_cross_reference “GOC:hjd”
obsolete protein depalmitoylation deprecated true
obsolete protein depalmitoylation comment “The reason for obsoletion is that this term represents a molecular function, not a biological process. Consider instead annotating to the molecular function ‘palmitoyl-(protein) hydrolase activity’ (GO:0008474).”
obsolete protein depalmitoylation label “obsolete protein depalmitoylation”

obsolete regulation of establishment of bipolar cell polarity regulating cell shape `http://purl.obolibrary.org/obo/GO_0061160`

Removed

obsolete regulation of establishment of bipolar cell polarity regulating cell shape definition “Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity that contributes to the shape of a cell.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:vw”
obsolete regulation of establishment of bipolar cell polarity regulating cell shape label “regulation of establishment of bipolar cell polarity regulating cell shape”
obsolete regulation of establishment of bipolar cell polarity regulating cell shape SubClassOf regulation of establishment of bipolar cell polarity
obsolete regulation of establishment of bipolar cell polarity regulating cell shape SubClassOf obsolete regulation of establishment or maintenance of bipolar cell polarity regulating cell shape

Added

obsolete regulation of establishment of bipolar cell polarity regulating cell shape term tracker item “https://github.com/geneontology/go-ontology/issues/21217”^^anyURI
obsolete regulation of establishment of bipolar cell polarity regulating cell shape term replaced by establishment or maintenance of bipolar cell polarity
obsolete regulation of establishment of bipolar cell polarity regulating cell shape definition “OBSOLETE. Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity that contributes to the shape of a cell.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:vw”
obsolete regulation of establishment of bipolar cell polarity regulating cell shape deprecated true
obsolete regulation of establishment of bipolar cell polarity regulating cell shape comment “The reason for obsoletion is that this term was made in error.”
obsolete regulation of establishment of bipolar cell polarity regulating cell shape label “obsolete regulation of establishment of bipolar cell polarity regulating cell shape”

obsolete regulation of establishment or maintenance of bipolar cell polarity regulating cell shape `http://purl.obolibrary.org/obo/GO_2000100`

Removed

obsolete regulation of establishment or maintenance of bipolar cell polarity regulating cell shape definition “Any process that modulates the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape.”
- database_cross_reference “GOC:obol”
obsolete regulation of establishment or maintenance of bipolar cell polarity regulating cell shape label “regulation of establishment or maintenance of bipolar cell polarity regulating cell shape”
obsolete regulation of establishment or maintenance of bipolar cell polarity regulating cell shape EquivalentTo biological regulation and (regulates some obsolete establishment or maintenance of bipolar cell polarity regulating cell shape)
obsolete regulation of establishment or maintenance of bipolar cell polarity regulating cell shape SubClassOf regulation of establishment or maintenance of bipolar cell polarity
obsolete regulation of establishment or maintenance of bipolar cell polarity regulating cell shape SubClassOf regulation of establishment or maintenance of cell polarity regulating cell shape
obsolete regulation of establishment or maintenance of bipolar cell polarity regulating cell shape SubClassOf regulates some obsolete establishment or maintenance of bipolar cell polarity regulating cell shape

Added

obsolete regulation of establishment or maintenance of bipolar cell polarity regulating cell shape term tracker item “https://github.com/geneontology/go-ontology/issues/21217”^^anyURI
obsolete regulation of establishment or maintenance of bipolar cell polarity regulating cell shape term replaced by establishment or maintenance of bipolar cell polarity
obsolete regulation of establishment or maintenance of bipolar cell polarity regulating cell shape definition “OBSOLETE. Any process that modulates the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape.”
- database_cross_reference “GOC:obol”
obsolete regulation of establishment or maintenance of bipolar cell polarity regulating cell shape deprecated true
obsolete regulation of establishment or maintenance of bipolar cell polarity regulating cell shape comment “The reason for obsoletion is that this term was made in error.”
obsolete regulation of establishment or maintenance of bipolar cell polarity regulating cell shape label “obsolete regulation of establishment or maintenance of bipolar cell polarity regulating cell shape”

obsolete regulation of maintenance of bipolar cell polarity regulating cell shape `http://purl.obolibrary.org/obo/GO_2000115`

Removed

obsolete regulation of maintenance of bipolar cell polarity regulating cell shape definition “Any process that modulates the frequency, rate or extent of maintenance of bipolar cell polarity regulating in cell shape.”
- database_cross_reference “GOC:obol”
obsolete regulation of maintenance of bipolar cell polarity regulating cell shape label “regulation of maintenance of bipolar cell polarity regulating cell shape”
obsolete regulation of maintenance of bipolar cell polarity regulating cell shape EquivalentTo biological regulation and (regulates some obsolete maintenance of bipolar cell polarity regulating cell shape)
obsolete regulation of maintenance of bipolar cell polarity regulating cell shape SubClassOf obsolete regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
obsolete regulation of maintenance of bipolar cell polarity regulating cell shape SubClassOf regulates some obsolete maintenance of bipolar cell polarity regulating cell shape

Added

obsolete regulation of maintenance of bipolar cell polarity regulating cell shape term tracker item “https://github.com/geneontology/go-ontology/issues/21217”^^anyURI
obsolete regulation of maintenance of bipolar cell polarity regulating cell shape term replaced by establishment or maintenance of bipolar cell polarity
obsolete regulation of maintenance of bipolar cell polarity regulating cell shape definition “OBSOLETE. Any process that modulates the frequency, rate or extent of maintenance of bipolar cell polarity regulating in cell shape.”
- database_cross_reference “GOC:obol”
obsolete regulation of maintenance of bipolar cell polarity regulating cell shape deprecated true
obsolete regulation of maintenance of bipolar cell polarity regulating cell shape comment “The reason for obsoletion is that this term was made in error.”
obsolete regulation of maintenance of bipolar cell polarity regulating cell shape label “obsolete regulation of maintenance of bipolar cell polarity regulating cell shape”

obsolete substrate localization to autophagosome `http://purl.obolibrary.org/obo/GO_0061753`

Removed

obsolete substrate localization to autophagosome definition “The localization process by which an autophagic substrate is delivered to a forming autophagosome.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:PARL”
- database_cross_reference “GOC:pad”
- database_cross_reference “PMID:23545414”
obsolete substrate localization to autophagosome label “substrate localization to autophagosome”
obsolete substrate localization to autophagosome SubClassOf establishment of localization in cell
obsolete substrate localization to autophagosome SubClassOf part of some autophagosome assembly

Added

obsolete substrate localization to autophagosome term tracker item “https://github.com/geneontology/go-ontology/issues/32304”^^anyURI
obsolete substrate localization to autophagosome definition “OBSOLETE. The localization process by which an autophagic substrate is delivered to a forming autophagosome.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:PARL”
- database_cross_reference “GOC:pad”
- database_cross_reference “PMID:23545414”
obsolete substrate localization to autophagosome deprecated true
obsolete substrate localization to autophagosome comment “The reason for obsoletion is that this term was an unnecessary grouping term: localization terms that are not transport terms are largely uninformative about biological process. The intended biology in every observed use is better captured by a specific selective-autophagy term (e.g. mitophagy, glycophagy, reticulophagy). See the annotation review at https://github.com/geneontology/go-annotation/issues/6497 for per-annotation transfer recommendations.”
obsolete substrate localization to autophagosome label “obsolete substrate localization to autophagosome”

obsolete thioredoxin peroxidase activity `http://purl.obolibrary.org/obo/GO_0008379`

Removed

obsolete thioredoxin peroxidase activity database_cross_reference “MetaCyc:RXN0-267”
obsolete thioredoxin peroxidase activity database_cross_reference “RHEA:63528”
obsolete thioredoxin peroxidase activity exactMatch 63528
obsolete thioredoxin peroxidase activity definition “Catalysis of the reaction: [thioredoxin]-dithiol + H2O2 = [thioredoxin]-disulfide + H2O.”
- database_cross_reference “RHEA:63528”
obsolete thioredoxin peroxidase activity label “thioredoxin peroxidase activity”
obsolete thioredoxin peroxidase activity SubClassOf thioredoxin-dependent peroxiredoxin activity

Added

obsolete thioredoxin peroxidase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32388”^^anyURI
obsolete thioredoxin peroxidase activity term replaced by thioredoxin-dependent peroxiredoxin activity
obsolete thioredoxin peroxidase activity definition “OBSOLETE. Catalysis of the reaction: [thioredoxin]-dithiol + H2O2 = [thioredoxin]-disulfide + H2O.”
- database_cross_reference “RHEA:63528”
obsolete thioredoxin peroxidase activity deprecated true
obsolete thioredoxin peroxidase activity comment “This term was obsoleted because it is redundant with GO:0140824 thioredoxin-dependent peroxiredoxin activity. Both enzyme activities use thioredoxin; the nominal distinction was that GO:0008379/RHEA:63528 specified hydrogen peroxide as substrate while GO:0140824/RHEA:62620 uses a hydroperoxide (of which H2O2 is a subtype). RHEA:63528 has no proteins associated with it and this term has been misannotated for enzymes with broader hydroperoxide specificity.”
obsolete thioredoxin peroxidase activity label “obsolete thioredoxin peroxidase activity”

obsolete venom-mediated activation of pH-gated ion channel activity `http://purl.obolibrary.org/obo/GO_0044734`

Removed

obsolete venom-mediated activation of pH-gated ion channel activity definition “A process in which an organism initiates, promotes, or enhances the activity of a pH-gated (also known as acid-sensing ion channel (ASIC)) in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:23034652”
- database_cross_reference “GOC:fj”
obsolete venom-mediated activation of pH-gated ion channel activity label “venom-mediated activation of pH-gated ion channel activity”
obsolete venom-mediated activation of pH-gated ion channel activity SubClassOf obsolete venom-mediated perturbation of pH-gated ion channel activity

Added

obsolete venom-mediated activation of pH-gated ion channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
obsolete venom-mediated activation of pH-gated ion channel activity consider channel activator activity
obsolete venom-mediated activation of pH-gated ion channel activity definition “OBSOLETE. A process in which an organism initiates, promotes, or enhances the activity of a pH-gated (also known as acid-sensing ion channel (ASIC)) in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:23034652”
- database_cross_reference “GOC:fj”
obsolete venom-mediated activation of pH-gated ion channel activity deprecated true
obsolete venom-mediated activation of pH-gated ion channel activity comment “This term was obsoleted because it represents a molecular function.”
obsolete venom-mediated activation of pH-gated ion channel activity label “obsolete venom-mediated activation of pH-gated ion channel activity”

obsolete venom-mediated activation of voltage-gated sodium channel activity `http://purl.obolibrary.org/obo/GO_0044494`

Removed

obsolete venom-mediated activation of voltage-gated sodium channel activity definition “A process in which an organism initiates, promotes, or enhances the activity of a voltage-gated sodium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:21781281”
obsolete venom-mediated activation of voltage-gated sodium channel activity label “venom-mediated activation of voltage-gated sodium channel activity”
obsolete venom-mediated activation of voltage-gated sodium channel activity SubClassOf obsolete venom-mediated perturbation of voltage-gated sodium channel activity

Added

obsolete venom-mediated activation of voltage-gated sodium channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
obsolete venom-mediated activation of voltage-gated sodium channel activity consider sodium channel activator activity
obsolete venom-mediated activation of voltage-gated sodium channel activity definition “OBSOLETE. A process in which an organism initiates, promotes, or enhances the activity of a voltage-gated sodium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:21781281”
obsolete venom-mediated activation of voltage-gated sodium channel activity deprecated true
obsolete venom-mediated activation of voltage-gated sodium channel activity comment “This term was obsoleted because it represents a molecular function.”
obsolete venom-mediated activation of voltage-gated sodium channel activity label “obsolete venom-mediated activation of voltage-gated sodium channel activity”

obsolete venom-mediated inhibition of calcium channel activity `http://purl.obolibrary.org/obo/GO_0044473`

Removed

obsolete venom-mediated inhibition of calcium channel activity definition “A process in which an organism inhibits or disrupts the activity of a calcium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:20920515”
obsolete venom-mediated inhibition of calcium channel activity label “venom-mediated inhibition of calcium channel activity”
obsolete venom-mediated inhibition of calcium channel activity SubClassOf obsolete venom-mediated perturbation of calcium channel activity

Added

obsolete venom-mediated inhibition of calcium channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
obsolete venom-mediated inhibition of calcium channel activity consider calcium channel inhibitor activity
obsolete venom-mediated inhibition of calcium channel activity definition “OBSOLETE. A process in which an organism inhibits or disrupts the activity of a calcium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:20920515”
obsolete venom-mediated inhibition of calcium channel activity deprecated true
obsolete venom-mediated inhibition of calcium channel activity comment “This term was obsoleted because it represents a molecular function.”
obsolete venom-mediated inhibition of calcium channel activity label “obsolete venom-mediated inhibition of calcium channel activity”

obsolete venom-mediated inhibition of high voltage-gated calcium channel activity `http://purl.obolibrary.org/obo/GO_0044475`

Removed

obsolete venom-mediated inhibition of high voltage-gated calcium channel activity definition “A process in which an organism inhibits or disrupts the activity of a high voltage-gated calcium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:20920515”
obsolete venom-mediated inhibition of high voltage-gated calcium channel activity label “venom-mediated inhibition of high voltage-gated calcium channel activity”
obsolete venom-mediated inhibition of high voltage-gated calcium channel activity SubClassOf obsolete venom-mediated inhibition of voltage-gated calcium channel activity

Added

obsolete venom-mediated inhibition of high voltage-gated calcium channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
obsolete venom-mediated inhibition of high voltage-gated calcium channel activity consider calcium channel inhibitor activity
obsolete venom-mediated inhibition of high voltage-gated calcium channel activity definition “OBSOLETE. A process in which an organism inhibits or disrupts the activity of a high voltage-gated calcium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:20920515”
obsolete venom-mediated inhibition of high voltage-gated calcium channel activity deprecated true
obsolete venom-mediated inhibition of high voltage-gated calcium channel activity comment “This term was obsoleted because it represents a molecular function.”
obsolete venom-mediated inhibition of high voltage-gated calcium channel activity label “obsolete venom-mediated inhibition of high voltage-gated calcium channel activity”

obsolete venom-mediated inhibition of low voltage-gated calcium channel activity `http://purl.obolibrary.org/obo/GO_0044476`

Removed

obsolete venom-mediated inhibition of low voltage-gated calcium channel activity definition “A process in which an organism inhibits or disrupts the activity of a low voltage-gated calcium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:20920515”
obsolete venom-mediated inhibition of low voltage-gated calcium channel activity label “venom-mediated inhibition of low voltage-gated calcium channel activity”
obsolete venom-mediated inhibition of low voltage-gated calcium channel activity SubClassOf obsolete venom-mediated inhibition of voltage-gated calcium channel activity

Added

obsolete venom-mediated inhibition of low voltage-gated calcium channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
obsolete venom-mediated inhibition of low voltage-gated calcium channel activity consider calcium channel inhibitor activity
obsolete venom-mediated inhibition of low voltage-gated calcium channel activity definition “OBSOLETE. A process in which an organism inhibits or disrupts the activity of a low voltage-gated calcium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:20920515”
obsolete venom-mediated inhibition of low voltage-gated calcium channel activity deprecated true
obsolete venom-mediated inhibition of low voltage-gated calcium channel activity comment “This term was obsoleted because it represents a molecular function.”
obsolete venom-mediated inhibition of low voltage-gated calcium channel activity label “obsolete venom-mediated inhibition of low voltage-gated calcium channel activity”

obsolete venom-mediated inhibition of pH-gated ion channel activity `http://purl.obolibrary.org/obo/GO_0044735`

Removed

obsolete venom-mediated inhibition of pH-gated ion channel activity definition “A process in which an organism inhibits or disrupts the activity of a pH-gated (also known as acid-sensing ion channel (ASIC)) in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:23034652”
- database_cross_reference “GOC:fj”
obsolete venom-mediated inhibition of pH-gated ion channel activity label “venom-mediated inhibition of pH-gated ion channel activity”
obsolete venom-mediated inhibition of pH-gated ion channel activity SubClassOf obsolete venom-mediated perturbation of pH-gated ion channel activity

Added

obsolete venom-mediated inhibition of pH-gated ion channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
obsolete venom-mediated inhibition of pH-gated ion channel activity consider ion channel inhibitor activity
obsolete venom-mediated inhibition of pH-gated ion channel activity definition “OBSOLETE. A process in which an organism inhibits or disrupts the activity of a pH-gated (also known as acid-sensing ion channel (ASIC)) in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:23034652”
- database_cross_reference “GOC:fj”
obsolete venom-mediated inhibition of pH-gated ion channel activity deprecated true
obsolete venom-mediated inhibition of pH-gated ion channel activity comment “This term was obsoleted because it represents a molecular function.”
obsolete venom-mediated inhibition of pH-gated ion channel activity label “obsolete venom-mediated inhibition of pH-gated ion channel activity”

obsolete venom-mediated inhibition of voltage-gated calcium channel activity `http://purl.obolibrary.org/obo/GO_0044474`

Removed

obsolete venom-mediated inhibition of voltage-gated calcium channel activity definition “A process in which an organism inhibits or disrupts the activity of a voltage-gated calcium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:20920515”
obsolete venom-mediated inhibition of voltage-gated calcium channel activity label “venom-mediated inhibition of voltage-gated calcium channel activity”
obsolete venom-mediated inhibition of voltage-gated calcium channel activity SubClassOf obsolete venom-mediated inhibition of calcium channel activity

Added

obsolete venom-mediated inhibition of voltage-gated calcium channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
obsolete venom-mediated inhibition of voltage-gated calcium channel activity consider calcium channel inhibitor activity
obsolete venom-mediated inhibition of voltage-gated calcium channel activity definition “OBSOLETE. A process in which an organism inhibits or disrupts the activity of a voltage-gated calcium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:20920515”
obsolete venom-mediated inhibition of voltage-gated calcium channel activity deprecated true
obsolete venom-mediated inhibition of voltage-gated calcium channel activity comment “This term was obsoleted because it represents a molecular function.”
obsolete venom-mediated inhibition of voltage-gated calcium channel activity label “obsolete venom-mediated inhibition of voltage-gated calcium channel activity”

obsolete venom-mediated inhibition of voltage-gated potassium channel activity `http://purl.obolibrary.org/obo/GO_0044562`

Removed

obsolete venom-mediated inhibition of voltage-gated potassium channel activity definition “A process in which an organism inhibits or disrupts the activity of a voltage-gated potassium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
obsolete venom-mediated inhibition of voltage-gated potassium channel activity label “venom-mediated inhibition of voltage-gated potassium channel activity”
obsolete venom-mediated inhibition of voltage-gated potassium channel activity SubClassOf obsolete venom-mediated perturbation of voltage-gated potassium channel activity

Added

obsolete venom-mediated inhibition of voltage-gated potassium channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
obsolete venom-mediated inhibition of voltage-gated potassium channel activity consider voltage-gated potassium channel inhibitor activity
obsolete venom-mediated inhibition of voltage-gated potassium channel activity definition “OBSOLETE. A process in which an organism inhibits or disrupts the activity of a voltage-gated potassium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
obsolete venom-mediated inhibition of voltage-gated potassium channel activity deprecated true
obsolete venom-mediated inhibition of voltage-gated potassium channel activity comment “This term was obsoleted because it represents a molecular function.”
obsolete venom-mediated inhibition of voltage-gated potassium channel activity label “obsolete venom-mediated inhibition of voltage-gated potassium channel activity”

obsolete venom-mediated inhibition of voltage-gated sodium channel activity `http://purl.obolibrary.org/obo/GO_0044493`

Removed

obsolete venom-mediated inhibition of voltage-gated sodium channel activity definition “A process in which an organism inhibits or disrupts the activity of a voltage-gated sodium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:21781281”
obsolete venom-mediated inhibition of voltage-gated sodium channel activity label “venom-mediated inhibition of voltage-gated sodium channel activity”
obsolete venom-mediated inhibition of voltage-gated sodium channel activity SubClassOf obsolete venom-mediated perturbation of voltage-gated sodium channel activity

Added

obsolete venom-mediated inhibition of voltage-gated sodium channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
obsolete venom-mediated inhibition of voltage-gated sodium channel activity consider sodium channel inhibitor activity
obsolete venom-mediated inhibition of voltage-gated sodium channel activity definition “OBSOLETE. A process in which an organism inhibits or disrupts the activity of a voltage-gated sodium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:21781281”
obsolete venom-mediated inhibition of voltage-gated sodium channel activity deprecated true
obsolete venom-mediated inhibition of voltage-gated sodium channel activity comment “This term was obsoleted because it represents a molecular function.”
obsolete venom-mediated inhibition of voltage-gated sodium channel activity label “obsolete venom-mediated inhibition of voltage-gated sodium channel activity”

obsolete venom-mediated perturbation of calcium channel activity `http://purl.obolibrary.org/obo/GO_0044472`

Removed

obsolete venom-mediated perturbation of calcium channel activity definition “A process in which an organism alters or subverts the activity of a calcium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:20920515”
obsolete venom-mediated perturbation of calcium channel activity label “venom-mediated perturbation of calcium channel activity”
obsolete venom-mediated perturbation of calcium channel activity SubClassOf obsolete venom-mediated perturbation of ion channel activity

Added

obsolete venom-mediated perturbation of calcium channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
obsolete venom-mediated perturbation of calcium channel activity consider calcium channel regulator activity
obsolete venom-mediated perturbation of calcium channel activity definition “OBSOLETE. A process in which an organism alters or subverts the activity of a calcium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:20920515”
obsolete venom-mediated perturbation of calcium channel activity deprecated true
obsolete venom-mediated perturbation of calcium channel activity comment “This term was obsoleted because it represents a molecular function.”
obsolete venom-mediated perturbation of calcium channel activity label “obsolete venom-mediated perturbation of calcium channel activity”

obsolete venom-mediated perturbation of ion channel activity `http://purl.obolibrary.org/obo/GO_0044560`

Removed

obsolete venom-mediated perturbation of ion channel activity definition “A process in which an organism alters or subverts the activity of an ion channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
obsolete venom-mediated perturbation of ion channel activity label “venom-mediated perturbation of ion channel activity”
obsolete venom-mediated perturbation of ion channel activity SubClassOf venom-mediated perturbation of biological process

Added

obsolete venom-mediated perturbation of ion channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
obsolete venom-mediated perturbation of ion channel activity definition “OBSOLETE. A process in which an organism alters or subverts the activity of an ion channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
obsolete venom-mediated perturbation of ion channel activity deprecated true
obsolete venom-mediated perturbation of ion channel activity comment “This term was obsoleted because it represents a molecular function.”
obsolete venom-mediated perturbation of ion channel activity label “obsolete venom-mediated perturbation of ion channel activity”

obsolete venom-mediated perturbation of pH-gated ion channel activity `http://purl.obolibrary.org/obo/GO_0044733`

Removed

obsolete venom-mediated perturbation of pH-gated ion channel activity definition “A process in which an organism alters or subverts the activity of a pH-gated (also known as acid-sensing ion channel (ASIC)) in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:23034652”
- database_cross_reference “GOC:fj”
obsolete venom-mediated perturbation of pH-gated ion channel activity label “venom-mediated perturbation of pH-gated ion channel activity”
obsolete venom-mediated perturbation of pH-gated ion channel activity SubClassOf obsolete venom-mediated perturbation of ion channel activity

Added

obsolete venom-mediated perturbation of pH-gated ion channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
obsolete venom-mediated perturbation of pH-gated ion channel activity consider ion channel regulator activity
obsolete venom-mediated perturbation of pH-gated ion channel activity definition “OBSOLETE. A process in which an organism alters or subverts the activity of a pH-gated (also known as acid-sensing ion channel (ASIC)) in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:23034652”
- database_cross_reference “GOC:fj”
obsolete venom-mediated perturbation of pH-gated ion channel activity deprecated true
obsolete venom-mediated perturbation of pH-gated ion channel activity comment “This term was obsoleted because it represents a molecular function.”
obsolete venom-mediated perturbation of pH-gated ion channel activity label “obsolete venom-mediated perturbation of pH-gated ion channel activity”

obsolete venom-mediated perturbation of voltage-gated potassium channel activity `http://purl.obolibrary.org/obo/GO_0044559`

Removed

obsolete venom-mediated perturbation of voltage-gated potassium channel activity definition “A process in which an organism alters or subverts the activity of a voltage-gated potassium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
obsolete venom-mediated perturbation of voltage-gated potassium channel activity label “venom-mediated perturbation of voltage-gated potassium channel activity”
obsolete venom-mediated perturbation of voltage-gated potassium channel activity SubClassOf obsolete venom-mediated perturbation of ion channel activity

Added

obsolete venom-mediated perturbation of voltage-gated potassium channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
obsolete venom-mediated perturbation of voltage-gated potassium channel activity consider potassium channel regulator activity
obsolete venom-mediated perturbation of voltage-gated potassium channel activity definition “OBSOLETE. A process in which an organism alters or subverts the activity of a voltage-gated potassium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
obsolete venom-mediated perturbation of voltage-gated potassium channel activity deprecated true
obsolete venom-mediated perturbation of voltage-gated potassium channel activity comment “This term was obsoleted because it represents a molecular function.”
obsolete venom-mediated perturbation of voltage-gated potassium channel activity label “obsolete venom-mediated perturbation of voltage-gated potassium channel activity”

obsolete venom-mediated perturbation of voltage-gated sodium channel activity `http://purl.obolibrary.org/obo/GO_0044492`

Removed

obsolete venom-mediated perturbation of voltage-gated sodium channel activity definition “A process in which an organism alters or subverts the activity of a voltage-gated sodium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:21781281”
obsolete venom-mediated perturbation of voltage-gated sodium channel activity label “venom-mediated perturbation of voltage-gated sodium channel activity”
obsolete venom-mediated perturbation of voltage-gated sodium channel activity SubClassOf obsolete venom-mediated perturbation of ion channel activity

Added

obsolete venom-mediated perturbation of voltage-gated sodium channel activity term tracker item “https://github.com/geneontology/go-ontology/issues/32401”^^anyURI
obsolete venom-mediated perturbation of voltage-gated sodium channel activity consider sodium channel regulator activity
obsolete venom-mediated perturbation of voltage-gated sodium channel activity definition “OBSOLETE. A process in which an organism alters or subverts the activity of a voltage-gated sodium channel in another organism via the action of a venom.”
- database_cross_reference “GOC:jl”
- database_cross_reference “GOC:fj”
- database_cross_reference “PMID:21781281”
obsolete venom-mediated perturbation of voltage-gated sodium channel activity deprecated true
obsolete venom-mediated perturbation of voltage-gated sodium channel activity comment “This term was obsoleted because it represents a molecular function.”
obsolete venom-mediated perturbation of voltage-gated sodium channel activity label “obsolete venom-mediated perturbation of voltage-gated sodium channel activity”

obsolete very long-chain fatty acid beta-oxidation `http://purl.obolibrary.org/obo/GO_0140493`

Removed

obsolete very long-chain fatty acid beta-oxidation definition “A fatty acid beta-oxidation pathway acting on a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons. The partway stars with the conversion of an acyl-CoA to a trans-2-enoyl-CoA, catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).”
- database_cross_reference “PMID:32169171”
- database_cross_reference “PMID:17028011”
- database_cross_reference “GOC:ha”
obsolete very long-chain fatty acid beta-oxidation comment “While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).”
obsolete very long-chain fatty acid beta-oxidation label “very long-chain fatty acid beta-oxidation”
obsolete very long-chain fatty acid beta-oxidation SubClassOf very long-chain fatty acid catabolic process

Added

obsolete very long-chain fatty acid beta-oxidation term tracker item “https://github.com/geneontology/go-ontology/issues/32227”^^anyURI
obsolete very long-chain fatty acid beta-oxidation term replaced by very long-chain fatty acid catabolic process
obsolete very long-chain fatty acid beta-oxidation definition “OBSOLETE. A fatty acid beta-oxidation pathway acting on a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons. The partway stars with the conversion of an acyl-CoA to a trans-2-enoyl-CoA, catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).”
- database_cross_reference “PMID:32169171”
- database_cross_reference “PMID:17028011”
- database_cross_reference “GOC:ha”
obsolete very long-chain fatty acid beta-oxidation deprecated true
obsolete very long-chain fatty acid beta-oxidation comment “This term was obsoleted because it represents the same process as very long-chain fatty acid catabolic process ; GO:0042760.”
obsolete very long-chain fatty acid beta-oxidation label “obsolete very long-chain fatty acid beta-oxidation”

ocellus development `http://purl.obolibrary.org/obo/GO_0008056`

Removed

ocellus development definition “The process whose specific outcome is the progression of the ocellus over time, from its formation to the mature structure. The ocellus is a simple visual organ of insects.”
- database_cross_reference “http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540”

Added

ocellus development term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
ocellus development definition “The process whose specific outcome is the progression of the ocellus over time, from its formation to the mature structure. The ocellus is a simple visual organ of insects.”
- database_cross_reference “FBbt:00004505”

ocellus morphogenesis `http://purl.obolibrary.org/obo/GO_0048816`

Removed

ocellus morphogenesis definition “The process in which the anatomical structures of the ocellus are generated and organized. The ocellus is a simple visual organ of insects.”
- database_cross_reference “http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540”

Added

ocellus morphogenesis term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
ocellus morphogenesis definition “The process in which the anatomical structures of the ocellus are generated and organized. The ocellus is a simple visual organ of insects.”
- database_cross_reference “FBbt:00004505”

organophosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0090407`

Added

organophosphate biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/32294”^^anyURI
organophosphate biosynthetic process in_subset gocheck_do_not_annotate

organophosphate catabolic process `http://purl.obolibrary.org/obo/GO_0046434`

Added

organophosphate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/32294”^^anyURI
organophosphate catabolic process in_subset gocheck_do_not_annotate

organophosphate metabolic process `http://purl.obolibrary.org/obo/GO_0019637`

Added

organophosphate metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/32294”^^anyURI
organophosphate metabolic process in_subset gocheck_do_not_annotate

outward rectifier potassium channel inhibitor activity `http://purl.obolibrary.org/obo/GO_0140628`

Removed

outward rectifier potassium channel inhibitor activity SubClassOf potassium channel inhibitor activity

Added

outward rectifier potassium channel inhibitor activity SubClassOf voltage-gated potassium channel inhibitor activity

palmitoyl hydrolase activity `http://purl.obolibrary.org/obo/GO_0098599`

Removed

palmitoyl hydrolase activity SubClassOf part of some obsolete macromolecule depalmitoylation

periodic partitioning by pair rule gene `http://purl.obolibrary.org/obo/GO_0007366`

Removed

periodic partitioning by pair rule gene definition “Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities.”
- database_cross_reference “ISBN:0632030488”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

periodic partitioning by pair rule gene term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
periodic partitioning by pair rule gene definition “Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities.”
- database_cross_reference “ISBN:0632030488”
- database_cross_reference “ISBN:0879694238”

peroxiredoxin activity `http://purl.obolibrary.org/obo/GO_0051920`

Removed

peroxiredoxin activity database_cross_reference “RHEA:62624”
peroxiredoxin activity database_cross_reference “RHEA:62640”
peroxiredoxin activity narrowMatch 62624
peroxiredoxin activity narrowMatch 62640
peroxiredoxin activity definition “Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.”
- database_cross_reference “RHEA:10008”

Added

peroxiredoxin activity term tracker item “https://github.com/geneontology/go-ontology/issues/32405”^^anyURI
peroxiredoxin activity definition “Catalysis of the reaction: [protein]-dithiol + ROOH = [protein]-disulfide + H2O + ROH.”
- database_cross_reference “RHEA:10008”

peroxisomal protein quality control `http://purl.obolibrary.org/obo/GO_0170079`

Added

Class: peroxisomal protein quality control
peroxisomal protein quality control term tracker item “https://github.com/geneontology/go-ontology/issues/32442”^^anyURI
peroxisomal protein quality control created by “ew”
peroxisomal protein quality control creation date “2026-08-12T16:13:58Z”
peroxisomal protein quality control has_obo_namespace “biological_process”
peroxisomal protein quality control id “GO:0170079”
peroxisomal protein quality control definition “The chemical reactions and pathways resulting in the breakdown of dysfunctional peroxisomal proteins, independent of pexophagy.”
- database_cross_reference “PMID:25305535”
- database_cross_reference “PMID:37552037”
- database_cross_reference “PMID:19538506”
peroxisomal protein quality control label “peroxisomal protein quality control”
peroxisomal protein quality control SubClassOf protein quality control
peroxisomal protein quality control SubClassOf protein catabolic process

phagosome maturation `http://purl.obolibrary.org/obo/GO_0090382`

Removed

phagosome maturation SubClassOf has part some exocytosis

Added

phagosome maturation term tracker item “https://github.com/geneontology/go-ontology/issues/32152”^^anyURI
phagosome maturation SubClassOf has part some endocytosis

phosphocreatine metabolic process `http://purl.obolibrary.org/obo/GO_0006603`

Added

phosphocreatine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/32279”^^anyURI

positive regulation of cristae formation `http://purl.obolibrary.org/obo/GO_1903852`

Removed

positive regulation of cristae formation SubClassOf positive regulation of organelle organization

Added

positive regulation of cristae formation SubClassOf positive regulation of cellular component organization

posterior abdomen determination `http://purl.obolibrary.org/obo/GO_0007359`

Removed

posterior abdomen determination definition “The regionalization process in which the posterior (abdominal) regions of the embryo are specified by the gap genes.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:isa_complete”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

posterior abdomen determination term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
posterior abdomen determination definition “The regionalization process in which the posterior (abdominal) regions of the embryo are specified by the gap genes.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:isa_complete”
- database_cross_reference “ISBN:0879694238”

posterior compartment specification `http://purl.obolibrary.org/obo/GO_0007388`

Removed

posterior compartment specification definition “The process involved in the specification of cell identity in the posterior compartments of the segmented embryo.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

posterior compartment specification term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
posterior compartment specification definition “The process involved in the specification of cell identity in the posterior compartments of the segmented embryo.”
- database_cross_reference “ISBN:0879694238”

protein insertion into mitochondrial membrane `http://purl.obolibrary.org/obo/GO_0051204`

Removed

protein insertion into mitochondrial membrane SubClassOf establishment of localization in cell

protein quality control `http://purl.obolibrary.org/obo/GO_0006515`

Removed

protein quality control has_broad_synonym “protein quality control by the ubiquitin-proteasome system”
protein quality control has_exact_synonym “degradation of misfolded or incompletely synthesized proteins”
protein quality control has_exact_synonym “misfolded or incompletely synthesized protein breakdown”
protein quality control has_exact_synonym “misfolded or incompletely synthesized protein catabolic process”
protein quality control has_exact_synonym “misfolded or incompletely synthesized protein catabolism”
protein quality control has_exact_synonym “misfolded or incompletely synthesized protein degradation”
protein quality control has_exact_synonym “protein quality control (PQC)”
protein quality control definition “The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins.”
- database_cross_reference “GOC:jl”
protein quality control label “protein quality control for misfolded or incompletely synthesized proteins”
protein quality control SubClassOf protein catabolic process

Added

protein quality control term tracker item “https://github.com/geneontology/go-ontology/issues/32442”^^anyURI
protein quality control has_exact_synonym “PQC”
protein quality control has_narrow_synonym “degradation of misfolded or incompletely synthesized proteins”
protein quality control has_narrow_synonym “misfolded or incompletely synthesized protein breakdown”
protein quality control has_narrow_synonym “misfolded or incompletely synthesized protein catabolic process”
protein quality control has_narrow_synonym “misfolded or incompletely synthesized protein catabolism”
protein quality control has_narrow_synonym “misfolded or incompletely synthesized protein degradation”
protein quality control has_narrow_synonym “protein quality control by the ubiquitin-proteasome system”
protein quality control has_narrow_synonym “protein quality control for misfolded or incompletely synthesized proteins”
protein quality control definition “The chemical reactions and pathways resulting in the breakdown or refolding of misfolded, dysfunctional, or incompletely synthesized proteins.”
- database_cross_reference “PMID:21746797”
protein quality control label “protein quality control”
protein quality control SubClassOf cellular process

protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity `http://purl.obolibrary.org/obo/GO_0008982`

Removed

protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity SubClassOf active transmembrane transporter activity

Added

protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/27496”^^anyURI
protein-N(PI)-phosphohistidine-carbohydrate phosphotransferase activity SubClassOf group translocator activity

protein-phosphocysteine-sugar phosphotransferase activity `http://purl.obolibrary.org/obo/GO_0090563`

Removed

protein-phosphocysteine-sugar phosphotransferase activity SubClassOf active transmembrane transporter activity

Added

protein-phosphocysteine-sugar phosphotransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/27496”^^anyURI
protein-phosphocysteine-sugar phosphotransferase activity SubClassOf group translocator activity

purine-containing compound catabolic process `http://purl.obolibrary.org/obo/GO_0072523`

Removed

purine-containing compound catabolic process SubClassOf catabolic process

Added

purine-containing compound catabolic process SubClassOf nucleobase-containing small molecule catabolic process

rRNA (adenine-N6-)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0008988`

Removed

rRNA (adenine-N6-)-methyltransferase activity SubClassOf N-methyltransferase activity

Added

rRNA (adenine-N6-)-methyltransferase activity SubClassOf RNA (adenine-N6)-methyltransferase activity

regulation of cristae formation `http://purl.obolibrary.org/obo/GO_1903850`

Removed

regulation of cristae formation SubClassOf regulation of mitochondrion organization

Added

regulation of cristae formation SubClassOf regulation of cellular component organization

response to interleukin-5 `http://purl.obolibrary.org/obo/GO_7770102`

Added

Class: response to interleukin-5
response to interleukin-5 term tracker item “https://github.com/geneontology/go-ontology/issues/32411”^^anyURI
response to interleukin-5 created by “ai4c-agent”
response to interleukin-5 creation date “2026-08-04T23:16:15Z”
response to interleukin-5 has_exact_synonym “response to IL-5”
response to interleukin-5 has_obo_namespace “biological_process”
response to interleukin-5 id “GO:7770102”
response to interleukin-5 definition “Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-5 stimulus.”
- database_cross_reference “PMID:41207640”
response to interleukin-5 label “response to interleukin-5”
response to interleukin-5 SubClassOf response to cytokine

riboflavin kinase activity `http://purl.obolibrary.org/obo/GO_0008531`

Removed

riboflavin kinase activity definition “Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H+.”
- database_cross_reference “EC:2.7.1.26”
- database_cross_reference “RHEA:14357”

Added

riboflavin kinase activity term tracker item “https://github.com/geneontology/go-ontology/issues/32345”^^anyURI
riboflavin kinase activity definition “Catalysis of the reaction: riboflavin + ATP = FMN + ADP + H+.”
- database_cross_reference “RHEA:14357”

segment polarity determination `http://purl.obolibrary.org/obo/GO_0007367`

Removed

segment polarity determination definition “Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products.”
- database_cross_reference “ISBN:0632030488”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

segment polarity determination term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
segment polarity determination definition “Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products.”
- database_cross_reference “ISBN:0632030488”
- database_cross_reference “ISBN:0879694238”

segment specification `http://purl.obolibrary.org/obo/GO_0007379`

Removed

segment specification definition “The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

segment specification term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
segment specification definition “The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes.”
- database_cross_reference “ISBN:0879694238”

sex comb development `http://purl.obolibrary.org/obo/GO_0045498`

Removed

sex comb development definition “The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg.”
- database_cross_reference “http://fly.ebi.ac.uk”

Added

sex comb development term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
sex comb development definition “The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg.”
- database_cross_reference “FBbt:00004296”

subtelomeric heterochromatin formation `http://purl.obolibrary.org/obo/GO_0031509`

Removed

subtelomeric heterochromatin formation SubClassOf occurs in some chromosome, telomeric region

Added

subtelomeric heterochromatin formation term tracker item “https://github.com/geneontology/go-ontology/issues/32403”^^anyURI

sulfate assimilation `http://purl.obolibrary.org/obo/GO_0000103`

Added

sulfate assimilation term tracker item “https://github.com/geneontology/go-ontology/issues/32376”^^anyURI
sulfate assimilation SubClassOf nutrient assimilation

tRNA(Val) (adenine(37)-N6)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_7770054`

Removed

tRNA(Val) (adenine(37)-N6)-methyltransferase activity SubClassOf N-methyltransferase activity

Added

tRNA(Val) (adenine(37)-N6)-methyltransferase activity SubClassOf RNA (adenine-N6)-methyltransferase activity

terminal region determination `http://purl.obolibrary.org/obo/GO_0007362`

Removed

terminal region determination definition “Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

terminal region determination term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
terminal region determination definition “Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products.”
- database_cross_reference “ISBN:0879694238”

thioredoxin-dependent peroxiredoxin activity `http://purl.obolibrary.org/obo/GO_0140824`

Added

thioredoxin-dependent peroxiredoxin activity term tracker item “https://github.com/geneontology/go-ontology/issues/32388”^^anyURI
thioredoxin-dependent peroxiredoxin activity database_cross_reference “MetaCyc:RXN0-267”
thioredoxin-dependent peroxiredoxin activity database_cross_reference “RHEA:63528”
thioredoxin-dependent peroxiredoxin activity has_exact_synonym “TPx activity”
thioredoxin-dependent peroxiredoxin activity has_exact_synonym “TrxPx activity”
thioredoxin-dependent peroxiredoxin activity has_exact_synonym “thioredoxin peroxidase activity”
thioredoxin-dependent peroxiredoxin activity has_related_synonym “thiol peroxidase activity”
thioredoxin-dependent peroxiredoxin activity narrowMatch RXN0-267
thioredoxin-dependent peroxiredoxin activity narrowMatch 63528

thorax and anterior abdomen determination `http://purl.obolibrary.org/obo/GO_0007356`

Removed

thorax and anterior abdomen determination definition “Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

thorax and anterior abdomen determination term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
thorax and anterior abdomen determination definition “Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product.”
- database_cross_reference “ISBN:0879694238”

tripartite regional subdivision `http://purl.obolibrary.org/obo/GO_0007351`

Removed

tripartite regional subdivision definition “Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:isa_complete”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

tripartite regional subdivision term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
tripartite regional subdivision definition “Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:isa_complete”
- database_cross_reference “ISBN:0879694238”

urate catabolic process `http://purl.obolibrary.org/obo/GO_0019628`

Removed

urate catabolic process SubClassOf small molecule catabolic process

very long-chain fatty-acyl-CoA catabolic process `http://purl.obolibrary.org/obo/GO_0036113`

Removed

very long-chain fatty-acyl-CoA catabolic process comment “While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).”

voltage-gated potassium channel inhibitor activity `http://purl.obolibrary.org/obo/GO_7770090`

Added

Class: voltage-gated potassium channel inhibitor activity
voltage-gated potassium channel inhibitor activity term tracker item “https://github.com/geneontology/go-ontology/issues/32371”^^anyURI
voltage-gated potassium channel inhibitor activity created by “ai4c-agent”
voltage-gated potassium channel inhibitor activity creation date “2026-07-28T16:49:43Z”
voltage-gated potassium channel inhibitor activity has_exact_synonym “Kv channel inhibitor activity”
voltage-gated potassium channel inhibitor activity has_exact_synonym “Kv inhibitor activity”
voltage-gated potassium channel inhibitor activity has_exact_synonym “voltage-gated potassium channel (Kv) inhibitor activity”
voltage-gated potassium channel inhibitor activity has_obo_namespace “molecular_function”
voltage-gated potassium channel inhibitor activity id “GO:7770090”
voltage-gated potassium channel inhibitor activity definition “Binds to and stops, prevents, or reduces the activity of a voltage-gated potassium channel.”
- database_cross_reference “PMID:35797055”
voltage-gated potassium channel inhibitor activity label “voltage-gated potassium channel inhibitor activity”
voltage-gated potassium channel inhibitor activity SubClassOf potassium channel inhibitor activity
voltage-gated potassium channel inhibitor activity SubClassOf negatively regulates some voltage-gated potassium channel activity

zygotic determination of anterior/posterior axis, embryo `http://purl.obolibrary.org/obo/GO_0007354`

Removed

zygotic determination of anterior/posterior axis, embryo definition “The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade.”
- database_cross_reference “ISBN:0879694238”
- database_cross_reference “http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm”

Added

zygotic determination of anterior/posterior axis, embryo term tracker item “https://github.com/geneontology/go-ontology/issues/18983”^^anyURI
zygotic determination of anterior/posterior axis, embryo definition “The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade.”
- database_cross_reference “ISBN:0879694238”

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Ontology annotations

Removed

Added

‘de novo’ NAD+ biosynthetic process from L-tryptophan http://purl.obolibrary.org/obo/GO_0034354

Added

4’-phosphopantetheine phosphatase activity http://purl.obolibrary.org/obo/GO_7770095

Added

ABC-type cadmium transporter activity http://purl.obolibrary.org/obo/GO_0015434

Added

ATP-dependent folded protein transmembrane transporter activity http://purl.obolibrary.org/obo/GO_7770098

Added

ATP-dependent protein-RNA complex displacement activity http://purl.obolibrary.org/obo/GO_7770106

Added

D-sorbitol biosynthetic process http://purl.obolibrary.org/obo/GO_0006061

Added

D-xylose reductase (NADPH) activity http://purl.obolibrary.org/obo/GO_0032866

Added

ER lumen protein retrieval receptor activity http://purl.obolibrary.org/obo/GO_0046923

Removed

Added

ER membrane protein retrieval receptor activity http://purl.obolibrary.org/obo/GO_7770094

Added

FAD regeneration via ETF:ETFQO system http://purl.obolibrary.org/obo/GO_7770096

Added

FMN adenylyltransferase activity http://purl.obolibrary.org/obo/GO_0003919

Removed

Added

L-arabinose reductase (NADPH) activity http://purl.obolibrary.org/obo/GO_0032867

Added

L-methionine cycle http://purl.obolibrary.org/obo/GO_0033353

Removed

Added

NAD+ nucleosidase activity, cyclic ADP-ribose generating http://purl.obolibrary.org/obo/GO_0061809

Removed

Added

NADH-dependent peroxiredoxin activity http://purl.obolibrary.org/obo/GO_0102039

Removed

Added

P-type cadmium transporter activity http://purl.obolibrary.org/obo/GO_0008551

Removed

Added

RADAR pathway http://purl.obolibrary.org/obo/GO_0170074

Added

RNA (adenine-N6)-methyltransferase activity http://purl.obolibrary.org/obo/GO_7770107

Added

S-methylmethionine cycle http://purl.obolibrary.org/obo/GO_0033528

Removed

Added

Sca1 Ras guanyl-nucleotide exchange factor complex http://purl.obolibrary.org/obo/GO_0170078

Added

Sec body http://purl.obolibrary.org/obo/GO_7770092

Added

Sec body assembly http://purl.obolibrary.org/obo/GO_7770093

Added

Tim8-Tim13 complex http://purl.obolibrary.org/obo/GO_7770104

Added

Tim9-Tim10 complex http://purl.obolibrary.org/obo/GO_7770105

Added

U2 snRNA (adenine-N6)-methyltransferase activity http://purl.obolibrary.org/obo/GO_0106348

Added

U6 snRNA (adenine(43)-N6)-methyltransferase activity http://purl.obolibrary.org/obo/GO_0120048

Added

alcohol dehydrogenase (NAD+) activity http://purl.obolibrary.org/obo/GO_0004022

Removed

aldose reductase [NAD(P)H] activity http://purl.obolibrary.org/obo/GO_0004032

Removed

Added

ammonia assimilation cycle http://purl.obolibrary.org/obo/GO_0019676

Added

antennal development http://purl.obolibrary.org/obo/GO_0007469

Removed

Added

anterior compartment pattern formation http://purl.obolibrary.org/obo/GO_0007387

Removed

Added

‘de novo’ NAD+ biosynthetic process from L-tryptophan `http://purl.obolibrary.org/obo/GO_0034354`

4’-phosphopantetheine phosphatase activity `http://purl.obolibrary.org/obo/GO_7770095`

ABC-type cadmium transporter activity `http://purl.obolibrary.org/obo/GO_0015434`

ATP-dependent folded protein transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_7770098`

ATP-dependent protein-RNA complex displacement activity `http://purl.obolibrary.org/obo/GO_7770106`

D-sorbitol biosynthetic process `http://purl.obolibrary.org/obo/GO_0006061`

D-xylose reductase (NADPH) activity `http://purl.obolibrary.org/obo/GO_0032866`

ER lumen protein retrieval receptor activity `http://purl.obolibrary.org/obo/GO_0046923`

ER membrane protein retrieval receptor activity `http://purl.obolibrary.org/obo/GO_7770094`

FAD regeneration via ETF:ETFQO system `http://purl.obolibrary.org/obo/GO_7770096`

FMN adenylyltransferase activity `http://purl.obolibrary.org/obo/GO_0003919`

L-arabinose reductase (NADPH) activity `http://purl.obolibrary.org/obo/GO_0032867`

L-methionine cycle `http://purl.obolibrary.org/obo/GO_0033353`

NAD+ nucleosidase activity, cyclic ADP-ribose generating `http://purl.obolibrary.org/obo/GO_0061809`

NADH-dependent peroxiredoxin activity `http://purl.obolibrary.org/obo/GO_0102039`

P-type cadmium transporter activity `http://purl.obolibrary.org/obo/GO_0008551`

RADAR pathway `http://purl.obolibrary.org/obo/GO_0170074`

RNA (adenine-N6)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_7770107`

S-methylmethionine cycle `http://purl.obolibrary.org/obo/GO_0033528`

Sca1 Ras guanyl-nucleotide exchange factor complex `http://purl.obolibrary.org/obo/GO_0170078`

Sec body `http://purl.obolibrary.org/obo/GO_7770092`

Sec body assembly `http://purl.obolibrary.org/obo/GO_7770093`

Tim8-Tim13 complex `http://purl.obolibrary.org/obo/GO_7770104`

Tim9-Tim10 complex `http://purl.obolibrary.org/obo/GO_7770105`

U2 snRNA (adenine-N6)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0106348`

U6 snRNA (adenine(43)-N6)-methyltransferase activity `http://purl.obolibrary.org/obo/GO_0120048`

alcohol dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0004022`

aldose reductase [NAD(P)H] activity `http://purl.obolibrary.org/obo/GO_0004032`

ammonia assimilation cycle `http://purl.obolibrary.org/obo/GO_0019676`

antennal development `http://purl.obolibrary.org/obo/GO_0007469`

anterior compartment pattern formation `http://purl.obolibrary.org/obo/GO_0007387`

anterior region determination `http://purl.obolibrary.org/obo/GO_0007355`

anterior/posterior axis specification, embryo `http://purl.obolibrary.org/obo/GO_0008595`

autophagy cargo adaptor activity `http://purl.obolibrary.org/obo/GO_0160247`

binding `http://purl.obolibrary.org/obo/GO_0005488`

bipolar cell growth `http://purl.obolibrary.org/obo/GO_0042815`

blastoderm segmentation `http://purl.obolibrary.org/obo/GO_0007350`

carboxylic acid biosynthetic process `http://purl.obolibrary.org/obo/GO_0046394`

carboxylic acid catabolic process `http://purl.obolibrary.org/obo/GO_0046395`

cellular response to interleukin-5 `http://purl.obolibrary.org/obo/GO_7770103`

citrate-malate shuttle `http://purl.obolibrary.org/obo/GO_7770108`

compartment pattern specification `http://purl.obolibrary.org/obo/GO_0007386`

creatine metabolic process `http://purl.obolibrary.org/obo/GO_0006600`

cyclic ADP-ribose hydrolase activity `http://purl.obolibrary.org/obo/GO_0061812`

cytoplasm protein quality control `http://purl.obolibrary.org/obo/GO_0140455`

dissimilatory sulfate reduction `http://purl.obolibrary.org/obo/GO_0019420`

ent-kaurene biosynthetic process `http://purl.obolibrary.org/obo/GO_0033332`

exit from cytosolic ribosome hibernation `http://purl.obolibrary.org/obo/GO_7770110`

folate cycle `http://purl.obolibrary.org/obo/GO_0035999`

formaldehyde assimilation `http://purl.obolibrary.org/obo/GO_0019649`

fructose export from vacuole to cytosol `http://purl.obolibrary.org/obo/GO_1902334`

ganglioside metabolic process `http://purl.obolibrary.org/obo/GO_0001573`

gap endonuclease activity `http://purl.obolibrary.org/obo/GO_0170076`

glutaredoxin-dependent peroxiredoxin activity `http://purl.obolibrary.org/obo/GO_7770099`

glutathione-dependent peroxiredoxin activity `http://purl.obolibrary.org/obo/GO_7770101`

glycine decarboxylation via glycine cleavage system `http://purl.obolibrary.org/obo/GO_0019464`

granulocyte colony-stimulating factor signaling pathway `http://purl.obolibrary.org/obo/GO_0038158`

group translocator activity `http://purl.obolibrary.org/obo/GO_7770111`

heme export from vacuole to cytosol `http://purl.obolibrary.org/obo/GO_0140357`

interleukin-5-mediated signaling pathway `http://purl.obolibrary.org/obo/GO_0038043`