go-ontology

Ontology comparison

Left

Ontology IRI: http://purl.obolibrary.org/obo/go.owl
Version IRI: http://purl.obolibrary.org/obo/go/releases/2026-03-25/go.owl
Loaded from: file:/__w/go-ontology/go-ontology/src/ontology/go-lastrelease.owl

Right

Ontology IRI: http://purl.obolibrary.org/obo/go.owl
Version IRI: http://purl.obolibrary.org/obo/go/releases/2026-05-12/go.owl
Loaded from: file:/__w/go-ontology/go-ontology/src/ontology/go.ofn

versionInfo “2026-03-25”

versionInfo “2026-05-12”

(R)-2-hydroxyisocaproate dehydrogenase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31966”^^anyURI
(R)-2-hydroxyisocaproate dehydrogenase activity term replaced by (2R)-2-hydroxyacid dehydrogenase (NAD+) activity
(R)-2-hydroxyisocaproate dehydrogenase activity definition “OBSOLETE. Catalysis of the reaction: 2-oxoisocaproate + NADH + H+ = (R)-2-hydroxyisocaproate + NAD+.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:16957230”
(R)-2-hydroxyisocaproate dehydrogenase activity deprecated true
(R)-2-hydroxyisocaproate dehydrogenase activity comment “The reason for obsoletion is that this term is equivalent to GO:0140175 (2R)-2-hydroxyacid dehydrogenase (NAD+) activity. "(R)-2-hydroxyisocaproate dehydrogenase" is a synonym of EC:1.1.1.345 (D-2-hydroxyacid dehydrogenase (NAD+)), which is the exact match xref of GO:0140175. The reaction catalyzed (involving (R)-2-hydroxy-4-methylpentanoate / 2-oxoisocaproate, RHEA:10052) is a narrowMatch instance of the more general reaction in GO:0140175.”
(R)-2-hydroxyisocaproate dehydrogenase activity label “obsolete (R)-2-hydroxyisocaproate dehydrogenase activity”

(R)-sulfopropanediol 2-dehydrogenase activity database_cross_reference “MetaCyc:RXN-11729”
(R)-sulfopropanediol 2-dehydrogenase activity definition “Catalysis of the reaction: (2R)-3-sulfopropanediol(1-) + NAD = 2-oxo-3-hydroxy-propane-1-sulfonate + NADH + H+.”
- database_cross_reference “GOC:pz”
- database_cross_reference “PMID:20150239”
(R)-sulfopropanediol 2-dehydrogenase activity label “(R)-sulfopropanediol 2-dehydrogenase activity”

1,8-cineole synthase activity definition “Catalysis of the reaction: geranyl diphosphate(3-) + H2O = 1,8-cineole + diphosphoric acid.”
- database_cross_reference “GOC:pz”
- database_cross_reference “RHEA:32543”

1,8-cineole synthase activity definition “Catalysis of the reaction: geranyl diphosphate(3-) + H2O = 1,8-cineole + diphosphoric acid.”
- database_cross_reference “RHEA:32543”

2,5-dioxovalerate dehydrogenase (NADP+) activity definition “Catalysis of the reaction: 2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + H+.”
- database_cross_reference “EC:1.2.1.26”
- database_cross_reference “MetaCyc:25-DIOXOVALERATE-DEHYDROGENASE-RXN”

2,5-dioxovalerate dehydrogenase (NADP+) activity definition “Catalysis of the reaction: 2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + H+.”
- database_cross_reference “RHEA:11296”

2-aminobenzenesulfonate 2,3-dioxygenase activity definition “Catalysis of the reaction: 2-aminobenzenesulfonate + 2 H+ + NADH + O2 = 2,3-dihydroxybenzenesulfonate + NAD+ + NH4. 2,3-dihydroxybenzenesulfonate is also known as 3-sulfocatechol.”
- database_cross_reference “EC:1.14.12.14”
- database_cross_reference “RHEA:23468”

2-aminobenzenesulfonate 2,3-dioxygenase activity definition “Catalysis of the reaction: 2-aminobenzenesulfonate + 2 H+ + NADH + O2 = 2,3-dihydroxybenzenesulfonate + NAD+ + NH4. 2,3-dihydroxybenzenesulfonate is also known as 3-sulfocatechol.”
- database_cross_reference “RHEA:23468”

2-hydroxyisocaproate CoA-transferase activity has_exact_synonym “(R)-2-hydroxyisocaproate CoA-transferase activity”
2-hydroxyisocaproate CoA-transferase activity definition “Catalysis of the reaction: (R)-2-hydroxyisocaproate + isocaproyl-CoA = (R)-2-hydroxyisocaproyl-CoA + isocaproate.”
- database_cross_reference “PMID:16957230”
2-hydroxyisocaproate CoA-transferase activity label “2-hydroxyisocaproate CoA-transferase activity”

2-hydroxyquinoline 5,6-dioxygenase activity definition “Catalysis of the reaction: quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+.”
- database_cross_reference “EC:1.14.12.16”

2-hydroxyquinoline 5,6-dioxygenase activity definition “Catalysis of the reaction: quinolin-2-ol + NADH + O2 + H+ = 5,6-dihydroquinoline-2,5,6-triol + NAD+.”
- database_cross_reference “RHEA:10976”

3-butenylglucosinolate 2-hydroxylase activity definition “Catalysis of the reaction: gluconapin + a reduced electron acceptor + O2 = xi-progoitrin + an oxidized electron acceptor + H2O.”
- database_cross_reference “PMID:18945935”

3-butenylglucosinolate 2-hydroxylase activity definition “Catalysis of the reaction: gluconapin + a reduced electron acceptor + O2 = progoitrin + an oxidized electron acceptor + H2O.”
- database_cross_reference “RHEA:60628”
- database_cross_reference “PMID:18945935”

3-chlorobenzoate-3,4-oxygenase activity definition “Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor = 3-chlorobenzoate-cis-3,4-diol + an oxidized electron acceptor.”
- database_cross_reference “GOC:pz”
- database_cross_reference “PMID:8285670”

3-chlorobenzoate-3,4-oxygenase activity definition “Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor = 3-chlorobenzoate-cis-3,4-diol + an oxidized electron acceptor.”
- database_cross_reference “PMID:8285670”
- database_cross_reference “PMID:38488372”

3-oxoadipate CoA-transferase activity definition “Catalysis of the reaction: succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA.”
- database_cross_reference “EC:2.8.3.6”
- database_cross_reference “MetaCyc:3-OXOADIPATE-COA-TRANSFERASE-RXN”

3-oxoadipate CoA-transferase activity definition “Catalysis of the reaction: 3-oxoadipate + succinyl-CoA = 3-oxoadipyl-CoA + succinate.”
- database_cross_reference “RHEA:12048”

3-phenylpropionate dioxygenase activity definition “Catalysis of the reaction: 3-phenylpropionate + NADH + H+ + O2 = NAD+ + cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol.”
- database_cross_reference “UM-BBD_enzymeID:e0307”

3-phenylpropionate dioxygenase activity definition “Catalysis of the reaction: 3-phenylpropanoate + NADH + O2 + H+ = 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+.”
- database_cross_reference “RHEA:20357”

4-O-methyl-glucuronoyl methylesterase activity definition “Catalysis of the reaction: [X]-4-O-methyl-D-glucuronic acid + H2O = [X]-OH + methyl-D-glucuronic acid. This reaction is the hydrolysis of the ester linkage between 4-O-methyl-D-glucuronic acid (MeGlcA) and an alcohol (-OH) group attached to a molecule, denoted here as [X].”
- database_cross_reference “GOC:mengo_curators”
- database_cross_reference “PMID:16876163”

4-aminobenzoate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of 4-aminobenzoate, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins.”
- database_cross_reference “PMID:11377864”
- database_cross_reference “MetaCyc:PWY-6543”
- database_cross_reference “PMID:11960743”
- database_cross_reference “ISBN:0198506732”
4-aminobenzoate biosynthetic process SubClassOf para-aminobenzoic acid metabolic process

4-aminobenzoate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of 4-aminobenzoate, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins.”
- database_cross_reference “PMID:11377864”
- database_cross_reference “MetaCyc:PWY-6543”
- database_cross_reference “PMID:11960743”
4-aminobenzoate biosynthetic process SubClassOf benzene-containing compound metabolic process

4-chlorophenylacetate 3,4-dioxygenase activity definition “Catalysis of the reaction: 4-chlorophenylacetate + NADH + O2 = 3,4-dihydroxyphenylacetate + chloride + NAD+.”
- database_cross_reference “EC:1.14.12.9”
- database_cross_reference “RHEA:14689”

4-chlorophenylacetate 3,4-dioxygenase activity definition “Catalysis of the reaction: 4-chlorophenylacetate + NADH + O2 = 3,4-dihydroxyphenylacetate + chloride + NAD+.”
- database_cross_reference “RHEA:14689”

4-hydroxybenzoyl-CoA reductase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31969”^^anyURI
4-hydroxybenzoyl-CoA reductase activity definition “Catalysis of the reaction: oxidized 2[4Fe-4S]-[ferredoxin] + benzoyl-CoA + H2O = 4-hydroxybenzoyl-CoA + reduced 2[4Fe-4S]-[ferredoxin] + 2 H+.”
- database_cross_reference “RHEA:29603”
4-hydroxybenzoyl-CoA reductase activity SubClassOf oxidoreductase activity, acting on CH-OH group of donors

4-hydroxybutanoyl-CoA dehydratase activity definition “Catalysis of the reaction: 4-hydroxybutanoyl-CoA = vinylacetyl-CoA + H2O.”
- database_cross_reference “EC:4.2.1.120”

4-hydroxybutanoyl-CoA dehydratase activity definition “Catalysis of the reaction: 4-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O.”
- database_cross_reference “RHEA:26530”

4-hydroxybutyrate CoA-transferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31862”^^anyURI
4-hydroxybutyrate CoA-transferase activity term replaced by 4-hydroxybutanoyl-CoA dehydratase activity
4-hydroxybutyrate CoA-transferase activity definition “OBSOLETE. Catalysis of the transfer of a coenzyme A (CoA) group to 4-hydroxybutyrate.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:25452282”
4-hydroxybutyrate CoA-transferase activity deprecated true
4-hydroxybutyrate CoA-transferase activity comment “This term was obsoleted because it represents the same activity as 4-hydroxybutanoyl-CoA dehydratase activity ; GO:0043721. The term was incorrectly defined; the paper cited describes dehydration of 4-hydroxybutyryl-CoA to crotonyl-CoA ((2E)-butenoyl-CoA).”
4-hydroxybutyrate CoA-transferase activity label “obsolete 4-hydroxybutyrate CoA-transferase activity”

4-hydroxycatechol 1,2-dioxygenase activity label “4-hydroxycatechol 1,2-dioxygenase activity”

4-sulfobenzoate 3,4-dioxygenase activity definition “Catalysis of the reaction: 4-sulfobenzoate + H+ + NADH + O2 = 3,4-dihydroxybenzoate + NAD+ + sulfite.”
- database_cross_reference “EC:1.14.12.8”
- database_cross_reference “RHEA:13937”

4-sulfobenzoate 3,4-dioxygenase activity definition “Catalysis of the reaction: 4-sulfobenzoate + H+ + NADH + O2 = 3,4-dihydroxybenzoate + NAD+ + sulfite.”
- database_cross_reference “RHEA:13937”

5’-nucleotidase activity exactMatch 12484
5’-nucleotidase activity definition “Catalysis of the reaction: a 5’-ribonucleotide + H2O = a ribonucleoside + phosphate.”
- database_cross_reference “EC:3.1.3.5”
5’-nucleotidase activity has_related_synonym “5’-ribonucleotide phosphohydrolase activity”
- database_cross_reference “EC:3.1.3.5”

5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31862”^^anyURI
5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity database_cross_reference “RHEA:48656”
5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity exactMatch 48656
5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity definition “Catalysis of the reaction: 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate (5-HETE) + reduced [NADPH-hemoprotein reductase] + O2 = 5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate (5-oxo-ETE) + oxidized [NADPH-hemoprotein reductase] + H2O + H+.”
- database_cross_reference “PMID:9675028”
- database_cross_reference “RHEA:48656”
- database_cross_reference “PMID:1326548”

5-hydroxypentanoate CoA-transferase activity definition “Catalysis of the reaction: 5-hydroxypentanoate + acetyl-CoA = 5-hydroxy-pentanoyl-CoA + acetate.”
- database_cross_reference “RHEA:23496”
- database_cross_reference “EC:2.8.3.14”

5-hydroxypentanoate CoA-transferase activity definition “Catalysis of the reaction: 5-hydroxypentanoate + acetyl-CoA = 5-hydroxy-pentanoyl-CoA + acetate.”
- database_cross_reference “RHEA:23496”

7,8-dihydro-D-neopterin 2’,3’-cyclic phosphate phosphodiesterase activity definition “Catalysis of the reaction: 7,8-dihydro-D-neopterin 2’,3’-cyclic phosphate + H2O = 7,8-dihydroneopterin 3’-phosphate + H+.”
- database_cross_reference “PMID:19746965”
- database_cross_reference “GOC:mengo_curators”

ADP-ribosylarginine hydrolase activity label “ADP-ribosylarginine hydrolase activity”

ADP-ribosylglutamate hydrolase activity definition “Catalysis of the reaction: (ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = L-glutamyl-[protein] + ADP-ribose.”
- database_cross_reference “PMID:23481255”
ADP-ribosylglutamate hydrolase activity label “ADP-ribosylglutamate hydrolase activity”

ADP-ribosylserine hydrolase activity definition “Catalysis of the reaction: (ADP-D-ribosyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + ADP-ribose.”
- database_cross_reference “RHEA:58256”
- database_cross_reference “PMID:28650317”
- database_cross_reference “PMID:29234005”
ADP-ribosylserine hydrolase activity label “ADP-ribosylserine hydrolase activity”

ADP-ribosylserine hydrolase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31850”^^anyURI
ADP-ribosylserine hydrolase activity has_exact_synonym “ADP-ribosylserine hydrolase activity”
ADP-ribosylserine hydrolase activity definition “Catalysis of the reaction: O-(ADP-D-ribosyl)-L-seryl-[protein] + H2O = ADP-D-ribose + L-seryl-[protein].”
- database_cross_reference “RHEA:58256”
- database_cross_reference “PMID:28650317”
- database_cross_reference “PMID:29234005”
ADP-ribosylserine hydrolase activity label “ADP-ribosylserine-[protein] hydrolase activity”

ADP-riboxanase activity label “ADP-riboxanase activity”

ADP-riboxanase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31850”^^anyURI
ADP-riboxanase activity has_exact_synonym “ADP-riboxanase activity”
ADP-riboxanase activity label “ADP-riboxanase-[protein] activity”

Bfa1-Bub2 complex definition “A protein complex that acts as a two-component GTPase-activating protein for Tem1 GTPase, thus regulating a signal transduction cascade, called the mitotic exit network (MEN), which is required for mitotic exit and cytokinesis. Bub2/Bfa1 keeps Tem1 inactive until the spindle is properly oriented, thus inhibiting MEN activation.”
- database_cross_reference “PMID:16449187”
- database_cross_reference “GOC:bhm”
Bfa1-Bub2 complex label “Bfa1-Bub2 complex”

Bfa1-Bub2 complex term tracker item “https://github.com/geneontology/go-ontology/issues/31636”^^anyURI
Bfa1-Bub2 complex has_narrow_synonym “Bfa1-Bub2 complex”
Bfa1-Bub2 complex has_narrow_synonym “Byr4-Cdc16 GAP complex”
Bfa1-Bub2 complex definition “A protein complex that acts as a two-component GTPase-activating protein for the Tem1/Spg1 GTPase, thus regulating a signal transduction cascade (the mitotic exit network, MEN, in budding yeast; the septation initiation network, SIN, in fission yeast), which is required for mitotic exit and cytokinesis. The complex keeps the GTPase inactive until the spindle is properly oriented, thus inhibiting MEN/SIN activation.”
- database_cross_reference “PMID:16449187”
- database_cross_reference “GOC:bhm”
Bfa1-Bub2 complex label “SIN/MEN two-component GAP complex”

C-acyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31814”^^anyURI
C-acyltransferase activity term replaced by acyltransferase activity, transferring groups other than amino-acyl groups
C-acyltransferase activity definition “OBSOLETE. Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule.”
- database_cross_reference “GOC:ai”
C-acyltransferase activity deprecated true
C-acyltransferase activity comment “This term was obsoleted because it represents an unnecessary grouping class that lacks an EC cross-reference and leads to misclassification of children.”
C-acyltransferase activity label “obsolete C-acyltransferase activity”

Cypridina-luciferin 2-monooxygenase activity definition “Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light.”
- database_cross_reference “MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN”
- database_cross_reference “EC:1.13.12.6”

Cypridina-luciferin 2-monooxygenase activity definition “Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light.”
- database_cross_reference “EC:1.13.12.6”

DIBOA-glucoside oxygenase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31969”^^anyURI
DIBOA-glucoside oxygenase activity definition “Catalysis of the reaction: DIBOA beta-D-glucoside + 2-oxoglutarate + O2 = TRIBOA beta-D-glucoside + succinate + CO2.”
- database_cross_reference “RHEA:32115”
DIBOA-glucoside oxygenase activity SubClassOf 2-oxoglutarate-dependent dioxygenase activity

ER retention sequence binding definition “Binding to an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER.”
- database_cross_reference “GOC:ai”
ER retention sequence binding label “ER retention sequence binding”

ER retention sequence binding has_narrow_synonym “ER retention sequence binding”
ER retention sequence binding definition “Binding to an endoplasmic reticulum (ER) retention sequence, a short stretch of amino acids found in a protein that acts as a signal to retain the protein within the ER.”
- database_cross_reference “GOC:ai”
ER retention sequence binding label “ER lumen protein retrieval receptor activity”

Entner-Doudoroff pathway through 6-phosphogluconate term tracker item “https://github.com/geneontology/go-ontology/issues/31916”^^anyURI
Entner-Doudoroff pathway through 6-phosphogluconate term replaced by Entner-Doudoroff pathway
Entner-Doudoroff pathway through 6-phosphogluconate definition “OBSOLETE. A pathway that converts a carbohydrate to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it.”
- database_cross_reference “PMID:12981024”
- database_cross_reference “PMID:12921356”
- database_cross_reference “GOC:jl”
- database_cross_reference “MetaCyc:PWY-8004”
Entner-Doudoroff pathway through 6-phosphogluconate deprecated true
Entner-Doudoroff pathway through 6-phosphogluconate comment “This term was obsoleted because the variant Entner-Doudoroff pathways are better represented by the parent term GO:0061678 (Entner-Doudoroff pathway). MetaCyc treats these as ‘variant pathways’ and such variants are better captured as GO-CAMs rather than as nested ontology terms.”
Entner-Doudoroff pathway through 6-phosphogluconate label “obsolete Entner-Doudoroff pathway through 6-phosphogluconate”

Entner-Doudoroff pathway through gluconate term tracker item “https://github.com/geneontology/go-ontology/issues/31916”^^anyURI
Entner-Doudoroff pathway through gluconate term replaced by Entner-Doudoroff pathway
Entner-Doudoroff pathway through gluconate definition “OBSOLETE. The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate.”
- database_cross_reference “PMID:12921536”
- database_cross_reference “GOC:dph”
Entner-Doudoroff pathway through gluconate deprecated true
Entner-Doudoroff pathway through gluconate comment “This term was obsoleted because the variant Entner-Doudoroff pathways are better represented by the parent term GO:0061678 (Entner-Doudoroff pathway). MetaCyc treats these as ‘variant pathways’ and such variants are better captured as GO-CAMs rather than as nested ontology terms.”
Entner-Doudoroff pathway through gluconate label “obsolete Entner-Doudoroff pathway through gluconate”

Entner-Doudoroff pathway through gluconate to D-glyceraldehyde term tracker item “https://github.com/geneontology/go-ontology/issues/31916”^^anyURI
Entner-Doudoroff pathway through gluconate to D-glyceraldehyde term replaced by Entner-Doudoroff pathway
Entner-Doudoroff pathway through gluconate to D-glyceraldehyde definition “OBSOLETE. The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde.”
- database_cross_reference “PMID:12921536”
- database_cross_reference “GOC:dph”
- database_cross_reference “MetaCyc:NPGLUCAT-PWY”
Entner-Doudoroff pathway through gluconate to D-glyceraldehyde deprecated true
Entner-Doudoroff pathway through gluconate to D-glyceraldehyde comment “This term was obsoleted because the variant Entner-Doudoroff pathways are better represented by the parent term GO:0061678 (Entner-Doudoroff pathway). MetaCyc treats these as ‘variant pathways’ and such variants are better captured as GO-CAMs rather than as nested ontology terms.”
Entner-Doudoroff pathway through gluconate to D-glyceraldehyde label “obsolete Entner-Doudoroff pathway through gluconate to D-glyceraldehyde”

Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate term tracker item “https://github.com/geneontology/go-ontology/issues/31916”^^anyURI
Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate term replaced by Entner-Doudoroff pathway
Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate definition “OBSOLETE. The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde-3-phosphate.”
- database_cross_reference “PMID:12921536”
- database_cross_reference “GOC:dph”
Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate deprecated true
Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate comment “This term was obsoleted because the variant Entner-Doudoroff pathways are better represented by the parent term GO:0061678 (Entner-Doudoroff pathway). MetaCyc treats these as ‘variant pathways’ and such variants are better captured as GO-CAMs rather than as nested ontology terms.”
Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate label “obsolete Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate”

GABA metabolic process definition “The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.”
- database_cross_reference “ISBN:0198506732”
GABA metabolic process comment “See also the biological process term ‘neurotransmitter metabolic process ; GO:0042133’.”
GABA metabolic process label “GABA metabolic process”
GABA metabolic process SubClassOf monocarboxylic acid metabolic process
GABA metabolic process SubClassOf non-proteinogenic amino acid metabolic process

GABA metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI
GABA metabolic process consider GABA biosynthetic process
GABA metabolic process consider GABA catabolic process
GABA metabolic process definition “OBSOLETE. The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.”
- database_cross_reference “ISBN:0198506732”
GABA metabolic process deprecated true
GABA metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
GABA metabolic process label “obsolete GABA metabolic process”

L-arginine transmembrane transport term tracker item “https://github.com/geneontology/go-ontology/issues/31823”^^anyURI

L-dopa biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31703”^^anyURI
L-dopa biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of L-dopa.”
- database_cross_reference “GOC:bf”
- database_cross_reference “PMID:8822146”
- database_cross_reference “GOC:PARL”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “GO_REF:0000068”
L-dopa biosynthetic process deprecated true
L-dopa biosynthetic process comment “This term was obsoleted because there is no evidence that this process exists.”
L-dopa biosynthetic process label “obsolete L-dopa biosynthetic process”

L-dopa metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31703”^^anyURI
L-dopa metabolic process term replaced by L-dopa catabolic process
L-dopa metabolic process definition “OBSOLETE. The chemical reactions and pathways involving L-dopa.”
- database_cross_reference “GOC:bf”
- database_cross_reference “PMID:8822146”
- database_cross_reference “GOC:PARL”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “GO_REF:0000068”
L-dopa metabolic process deprecated true
L-dopa metabolic process comment “This term was obsoleted because there is no evidence that this process exists; L-dopa metabolism has been used in the literature to mean L-dopa degradation.”
L-dopa metabolic process label “obsolete L-dopa metabolic process”

L-glutamine family amino acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.”
- database_cross_reference “GOC:ai”
L-glutamine family amino acid biosynthetic process label “L-glutamine family amino acid biosynthetic process”

L-glutamine family amino acid biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/32000”^^anyURI
L-glutamine family amino acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of L-glutamate or any of the amino acids synthesised from it (L-glutamine, L-proline and L-arginine).”
- database_cross_reference “GOC:curators”
L-glutamine family amino acid biosynthetic process label “glutamate family amino acid biosynthetic process”

L-isoleucine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31839”^^anyURI
L-isoleucine catabolic process has_narrow_synonym “L-isoleucine catabolic process via Ehrlich pathway”
L-isoleucine catabolic process has_narrow_synonym “L-isoleucine degradation via Ehrlich pathway”

L-kynurenine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31588”^^anyURI
L-kynurenine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine).”
- database_cross_reference “GOC:yaf”
L-kynurenine catabolic process deprecated true
L-kynurenine catabolic process comment “This term was obsoleted because there is no evidence that this compound is specifically degraded.”
L-kynurenine catabolic process label “obsolete L-kynurenine catabolic process”

L-leucine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31839”^^anyURI
L-leucine catabolic process has_narrow_synonym “L-leucine degradation via Ehrlich pathway”
L-leucine catabolic process has_narrow_synonym “L-methionine catabolic process via Ehrlich pathway”

L-methionine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31839”^^anyURI
L-methionine catabolic process has_narrow_synonym “L-methionine catabolic process via Ehrlich pathway”
L-methionine catabolic process has_narrow_synonym “L-methionine degradation via Ehrlich pathway”

L-phenylalanine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31839”^^anyURI
L-phenylalanine catabolic process has_narrow_synonym “L-phenylalanine catabolic process via Ehrlich pathway”
L-phenylalanine catabolic process has_narrow_synonym “L-phenylalanine degradation via Ehrlich pathway”

L-tryptophan catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31839”^^anyURI
L-tryptophan catabolic process has_narrow_synonym “L-tryptophan catabolic process via Ehrlich pathway”
L-tryptophan catabolic process has_narrow_synonym “L-tryptophan degradation via Ehrlich pathway”

L-tryptophan metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI
L-tryptophan metabolic process consider L-tryptophan biosynthetic process
L-tryptophan metabolic process consider L-tryptophan catabolic process
L-tryptophan metabolic process definition “OBSOLETE. The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.”
- database_cross_reference “ISBN:0198547684”
L-tryptophan metabolic process deprecated true
L-tryptophan metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
L-tryptophan metabolic process label “obsolete L-tryptophan metabolic process”

L-valine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31839”^^anyURI
L-valine catabolic process has_narrow_synonym “valine degradation via Ehrlich pathway”

N-acyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31814”^^anyURI
N-acyltransferase activity term replaced by acyltransferase activity, transferring groups other than amino-acyl groups
N-acyltransferase activity definition “OBSOLETE. Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule.”
- database_cross_reference “GOC:ai”
N-acyltransferase activity deprecated true
N-acyltransferase activity comment “This term was obsoleted because it represents an unnecessary grouping class that lacks an EC cross-reference and leads to misclassification of children.”
N-acyltransferase activity label “obsolete N-acyltransferase activity”

O-acyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31814”^^anyURI
O-acyltransferase activity term replaced by acyltransferase activity, transferring groups other than amino-acyl groups
O-acyltransferase activity definition “OBSOLETE. Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule.”
- database_cross_reference “GOC:ai”
O-acyltransferase activity deprecated true
O-acyltransferase activity comment “This term was obsoleted because it represents an unnecessary grouping class that lacks an EC cross-reference and leads to misclassification of children.”
O-acyltransferase activity label “obsolete O-acyltransferase activity”

Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity definition “Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin.”
- database_cross_reference “MetaCyc:1.13.12.7-RXN”
- database_cross_reference “EC:1.13.12.7”

Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity definition “Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin.”
- database_cross_reference “EC:1.13.12.7”

RNA translocase activity comment “Note that some gene products that possess DNA translocase activity, such as members of the FtsK/SpoIIIE family, can be fixed in place by interactions with other components of the cell; the relative movement between the protein and DNA bound to it results in movement of the DNA within the cell, often across a membrane.”

RNA translocase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31772”^^anyURI

Renilla-luciferin 2-monooxygenase activity definition “Catalysis of the reaction: Renilla luciferin + O2 = oxidized Renilla luciferin + CO2 + light.”
- database_cross_reference “MetaCyc:RENILLA-LUCIFERIN-2-MONOOXYGENASE-RXN”
- database_cross_reference “EC:1.13.12.5”

Renilla-luciferin 2-monooxygenase activity definition “Catalysis of the reaction: Renilla luciferin + O2 = oxidized Renilla luciferin + CO2 + light.”
- database_cross_reference “EC:1.13.12.5”

S-acyltransferase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31814”^^anyURI
S-acyltransferase activity term replaced by acyltransferase activity, transferring groups other than amino-acyl groups
S-acyltransferase activity definition “OBSOLETE. Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule.”
- database_cross_reference “GOC:ai”
S-acyltransferase activity deprecated true
S-acyltransferase activity comment “This term was obsoleted because it represents an unnecessary grouping class that lacks an EC cross-reference and leads to misclassification of children.”
S-acyltransferase activity label “obsolete S-acyltransferase activity”

Watasenia-luciferin 2-monooxygenase activity definition “Catalysis of the reaction: Watasenia luciferin + O2 = oxidized Watasenia luciferin + CO2 + light.”
- database_cross_reference “MetaCyc:WATASEMIA-LUCIFERIN-2-MONOOXYGENASE-RXN”
- database_cross_reference “EC:1.13.12.8”

Watasenia-luciferin 2-monooxygenase activity definition “Catalysis of the reaction: Watasenia luciferin + O2 = oxidized Watasenia luciferin + CO2 + light.”
- database_cross_reference “EC:1.13.12.8”

acetate CoA-transferase activity definition “Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.”
- database_cross_reference “EC:2.8.3.8”

acetate CoA-transferase activity definition “Catalysis of the reaction: an acyl-CoA + acetate = a carboxylate + acetyl-CoA.”
- database_cross_reference “RHEA:13381”

acetoacetic acid biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31806”^^anyURI
acetoacetic acid biosynthetic process term replaced by ketone body biosynthetic process
acetoacetic acid biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH.”
- database_cross_reference “GOC:jl”
acetoacetic acid biosynthetic process deprecated true
acetoacetic acid biosynthetic process comment “This term was obsoleted because it represents a specific substrate of ketone body biosynthetic process ; GO:0046951.”
acetoacetic acid biosynthetic process label “obsolete acetoacetic acid biosynthetic process”

acetoacetic acid catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31806”^^anyURI
acetoacetic acid catabolic process term replaced by ketone body catabolic process
acetoacetic acid catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH.”
- database_cross_reference “GOC:jl”
acetoacetic acid catabolic process deprecated true
acetoacetic acid catabolic process comment “This term was obsoleted because it represents a specific substrate of ketone body catabolic process ; GO:0046952.”
acetoacetic acid catabolic process label “obsolete acetoacetic acid catabolic process”

acetoacetic acid metabolic process definition “The chemical reactions and pathways involving acetoacetic acid, 3-oxobutanoic acid; the empirical formula is C4H6O3 or CH3COCH2COOH.”
- database_cross_reference “Wikipedia:Acetoacetic_acid”
acetoacetic acid metabolic process label “acetoacetic acid metabolic process”
acetoacetic acid metabolic process SubClassOf short-chain fatty acid metabolic process
acetoacetic acid metabolic process SubClassOf ketone body metabolic process

acetoacetic acid metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31806”^^anyURI
acetoacetic acid metabolic process definition “OBSOLETE. The chemical reactions and pathways involving acetoacetic acid, 3-oxobutanoic acid; the empirical formula is C4H6O3 or CH3COCH2COOH.”
- database_cross_reference “Wikipedia:Acetoacetic_acid”
acetoacetic acid metabolic process deprecated true
acetoacetic acid metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
acetoacetic acid metabolic process label “obsolete acetoacetic acid metabolic process”

acrolein reductase activity definition “Catalysis of the reaction: acrolein + NADPH + H+ = propanal + NADP.”
- database_cross_reference “GOC:pz”
- database_cross_reference “PMID:21169366”

actin capping protein of dynactin complex definition “A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, nucleates the polymerization of actin monomers but does not sever actin filaments, and which is a part of the dynactin complex.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:18221362”
- database_cross_reference “PMID:18544499”
actin capping protein of dynactin complex label “actin capping protein of dynactin complex”
actin capping protein of dynactin complex EquivalentTo F-actin capping protein complex and (part of some dynactin complex)
actin capping protein of dynactin complex SubClassOf F-actin capping protein complex
actin capping protein of dynactin complex SubClassOf part of some dynactin complex

actin capping protein of dynactin complex term tracker item “https://github.com/geneontology/go-ontology/issues/31956”^^anyURI
actin capping protein of dynactin complex term replaced by F-actin capping protein complex
actin capping protein of dynactin complex definition “OBSOLETE. A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, nucleates the polymerization of actin monomers but does not sever actin filaments, and which is a part of the dynactin complex.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:18221362”
- database_cross_reference “PMID:18544499”
actin capping protein of dynactin complex deprecated true
actin capping protein of dynactin complex comment “This term was obsoleted because it is redundant with GO:0008290 (F-actin capping protein complex). Annotations can be migrated to the replacement term.”
actin capping protein of dynactin complex label “obsolete actin capping protein of dynactin complex”

activation of bipolar cell growth definition “Any process that initiates the inactive process of bipolar cell growth, polarized growth from both ends of a cell.”
- database_cross_reference “GOC:ai”
activation of bipolar cell growth label “activation of bipolar cell growth”
activation of bipolar cell growth SubClassOf positive regulation of bipolar cell growth

activation of bipolar cell growth term tracker item “https://github.com/geneontology/go-ontology/issues/31746”^^anyURI
activation of bipolar cell growth term replaced by positive regulation of bipolar cell growth
activation of bipolar cell growth definition “OBSOLETE. Any process that initiates the inactive process of bipolar cell growth, polarized growth from both ends of a cell.”
- database_cross_reference “GOC:ai”
activation of bipolar cell growth deprecated true
activation of bipolar cell growth comment “This term was obsoleted because it represented the same process as its parent, positive regulation of bipolar cell growth ; GO:0051518.”
activation of bipolar cell growth label “obsolete activation of bipolar cell growth”

alkyl hydroperoxide reductase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31961”^^anyURI
alkyl hydroperoxide reductase activity term replaced by NADH-dependent peroxiredoxin activity
alkyl hydroperoxide reductase activity definition “OBSOLETE. Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol.”
- database_cross_reference “GOC:curators”
alkyl hydroperoxide reductase activity deprecated true
alkyl hydroperoxide reductase activity comment “The reason for obsoletion is that, despite the generic-sounding name, this term represented a substrate-specific activity that is more specific than the specificity of any known gene product. ‘Alkyl hydroperoxide reductase’ is listed as a synonym of EC 1.11.1.26, which corresponds to GO:0102039 NADH-dependent peroxiredoxin activity, the appropriate replacement.”
alkyl hydroperoxide reductase activity label “obsolete alkyl hydroperoxide reductase activity”

alpha-amino acid biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31993”^^anyURI
alpha-amino acid biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of an alpha-amino acid.”
- database_cross_reference “GOC:TermGenie”
alpha-amino acid biosynthetic process deprecated true
alpha-amino acid biosynthetic process comment “The reason for obsoletion is that this term was an unnecessary grouping term and more specific terms were created.”
alpha-amino acid biosynthetic process label “obsolete alpha-amino acid biosynthetic process”

alpha-amino acid catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31993”^^anyURI
alpha-amino acid catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid.”
- database_cross_reference “GOC:TermGenie”
alpha-amino acid catabolic process deprecated true
alpha-amino acid catabolic process comment “The reason for obsoletion is that this term was an unnecessary grouping term.”
alpha-amino acid catabolic process label “obsolete alpha-amino acid catabolic process”

alpha-amino acid metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31993”^^anyURI
alpha-amino acid metabolic process definition “OBSOLETE. The chemical reactions and pathways involving an alpha-amino acid.”
- database_cross_reference “GOC:TermGenie”
alpha-amino acid metabolic process deprecated true
alpha-amino acid metabolic process comment “The reason for obsoletion is that this term was an unnecessary grouping term and more specific terms were created.”
alpha-amino acid metabolic process label “obsolete alpha-amino acid metabolic process”

amino acid catabolic process to alcohol via Ehrlich pathway definition “The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.”
- database_cross_reference “GOC:krc”
- database_cross_reference “PMID:18281432”
amino acid catabolic process to alcohol via Ehrlich pathway label “amino acid catabolic process to alcohol via Ehrlich pathway”
amino acid catabolic process to alcohol via Ehrlich pathway SubClassOf amino acid catabolic process via Ehrlich pathway
amino acid catabolic process to alcohol via Ehrlich pathway SubClassOf alcohol biosynthetic process

amino acid catabolic process to alcohol via Ehrlich pathway term tracker item “https://github.com/geneontology/go-ontology/issues/31839”^^anyURI
amino acid catabolic process to alcohol via Ehrlich pathway definition “OBSOLETE. The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.”
- database_cross_reference “GOC:krc”
- database_cross_reference “PMID:18281432”
amino acid catabolic process to alcohol via Ehrlich pathway deprecated true
amino acid catabolic process to alcohol via Ehrlich pathway comment “This term was obsoleted because it represents multiple specific pathways. Consider specific amino acid catabolic processes.”
amino acid catabolic process to alcohol via Ehrlich pathway label “obsolete amino acid catabolic process to alcohol via Ehrlich pathway”

amino acid catabolic process to carboxylic acid via Ehrlich pathway definition “The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.”
- database_cross_reference “GOC:krc”
- database_cross_reference “PMID:18281432”
amino acid catabolic process to carboxylic acid via Ehrlich pathway label “amino acid catabolic process to carboxylic acid via Ehrlich pathway”
amino acid catabolic process to carboxylic acid via Ehrlich pathway SubClassOf amino acid catabolic process via Ehrlich pathway
amino acid catabolic process to carboxylic acid via Ehrlich pathway SubClassOf carboxylic acid biosynthetic process

amino acid catabolic process to carboxylic acid via Ehrlich pathway term tracker item “https://github.com/geneontology/go-ontology/issues/31839”^^anyURI
amino acid catabolic process to carboxylic acid via Ehrlich pathway definition “OBSOLETE. The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.”
- database_cross_reference “GOC:krc”
- database_cross_reference “PMID:18281432”
amino acid catabolic process to carboxylic acid via Ehrlich pathway deprecated true
amino acid catabolic process to carboxylic acid via Ehrlich pathway comment “This term was obsoleted because it represents multiple specific pathways. Consider specific amino acid catabolic processes.”
amino acid catabolic process to carboxylic acid via Ehrlich pathway label “obsolete amino acid catabolic process to carboxylic acid via Ehrlich pathway”

amino acid catabolic process via Ehrlich pathway definition “The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols or carboxylic acids containing one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives, sometimes referred to as fusel acids, may be produced instead of alcohols.”
- database_cross_reference “GOC:krc”
- database_cross_reference “PMID:18281432”
amino acid catabolic process via Ehrlich pathway label “amino acid catabolic process via Ehrlich pathway”
amino acid catabolic process via Ehrlich pathway SubClassOf amino acid catabolic process

amino acid catabolic process via Ehrlich pathway term tracker item “https://github.com/geneontology/go-ontology/issues/31839”^^anyURI
amino acid catabolic process via Ehrlich pathway definition “OBSOLETE. The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols or carboxylic acids containing one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives, sometimes referred to as fusel acids, may be produced instead of alcohols.”
- database_cross_reference “GOC:krc”
- database_cross_reference “PMID:18281432”
amino acid catabolic process via Ehrlich pathway deprecated true
amino acid catabolic process via Ehrlich pathway comment “This term was obsoleted because it represents multiple specific pathways. Consider specific amino acid catabolic processes.”
amino acid catabolic process via Ehrlich pathway label “obsolete amino acid catabolic process via Ehrlich pathway”

anaerobic carbon-monoxide dehydrogenase activity definition “Catalysis of the reaction: CO + H2O + oxidized ferredoxin = CO2 + reduced ferredoxin.”
- database_cross_reference “RHEA:21040”

anaerobic carbon-monoxide dehydrogenase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31984”^^anyURI
anaerobic carbon-monoxide dehydrogenase activity definition “Catalysis of the reaction: CO + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O = 2 reduced [2Fe-2S]-[ferredoxin] + CO2 + 2 H+.”
- database_cross_reference “RHEA:21040”

aromatic amino acid family biosynthetic process definition “The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).”
- database_cross_reference “GOC:curators”
aromatic amino acid family biosynthetic process label “aromatic amino acid family biosynthetic process”

aromatic amino acid family biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/32000”^^anyURI
aromatic amino acid family biosynthetic process definition “The chemical reactions and pathways resulting in the formation of an amino acid whose structure includes an aromatic ring.”
- database_cross_reference “GOC:curators”
aromatic amino acid family biosynthetic process label “aromatic amino acid biosynthetic process”

aromatic amino acid family biosynthetic process, prephenate pathway term tracker item “https://github.com/geneontology/go-ontology/issues/32005”^^anyURI
aromatic amino acid family biosynthetic process, prephenate pathway consider L-tyrosine biosynthetic process
aromatic amino acid family biosynthetic process, prephenate pathway consider L-phenylalanine biosynthetic process
aromatic amino acid family biosynthetic process, prephenate pathway definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of phenylalanine and tyrosine from other compounds, including chorismate, via the intermediate prephenate.”
- database_cross_reference “GOC:mah”
- database_cross_reference “ISBN:0471331309”
- database_cross_reference “MetaCyc:PWY-3481”
aromatic amino acid family biosynthetic process, prephenate pathway deprecated true
aromatic amino acid family biosynthetic process, prephenate pathway comment “This term was obsoleted because it represents a pre-composed pathway combining L-phenylalanine and L-tyrosine biosynthesis. MetaCyc:PWY-3481 is the ‘superpathway of L-phenylalanine and L-tyrosine biosynthesis’ and is composed of two separate pathways (PWY-3462 L-phenylalanine biosynthesis II and PWY-3461 L-tyrosine biosynthesis II) which are already represented as narrowMatch xrefs on GO:0009094 (L-phenylalanine biosynthetic process) and GO:0006571 (L-tyrosine biosynthetic process), respectively. Annotations should be transferred to the appropriate consider term(s).”
aromatic amino acid family biosynthetic process, prephenate pathway label “obsolete aromatic amino acid biosynthetic process, prephenate pathway”

aromatic amino acid family catabolic process definition “The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).”
- database_cross_reference “GOC:curators”
aromatic amino acid family catabolic process label “aromatic amino acid family catabolic process”

aromatic amino acid family catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/32000”^^anyURI
aromatic amino acid family catabolic process definition “The chemical reactions and pathways resulting in the breakdown of an amino acid whose structure includes an aromatic ring.”
- database_cross_reference “GOC:curators”
aromatic amino acid family catabolic process label “aromatic amino acid catabolic process”

aromatic amino acid family catabolic process to alcohol via Ehrlich pathway definition “The chemical reactions and pathways involving the catabolism of aromatic amino acids to produce aromatic alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanol, 4-hydroxyphenylethanol, or tryptophol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.”
- database_cross_reference “GOC:krc”
- database_cross_reference “PMID:18281432”
aromatic amino acid family catabolic process to alcohol via Ehrlich pathway label “aromatic amino acid family catabolic process to alcohol via Ehrlich pathway”
aromatic amino acid family catabolic process to alcohol via Ehrlich pathway SubClassOf amino acid catabolic process to alcohol via Ehrlich pathway
aromatic amino acid family catabolic process to alcohol via Ehrlich pathway SubClassOf aromatic amino acid family catabolic process

aromatic amino acid family catabolic process to alcohol via Ehrlich pathway term tracker item “https://github.com/geneontology/go-ontology/issues/31839”^^anyURI
aromatic amino acid family catabolic process to alcohol via Ehrlich pathway consider L-phenylalanine catabolic process
aromatic amino acid family catabolic process to alcohol via Ehrlich pathway consider L-tryptophan catabolic process
aromatic amino acid family catabolic process to alcohol via Ehrlich pathway consider L-tyrosine catabolic process
aromatic amino acid family catabolic process to alcohol via Ehrlich pathway definition “OBSOLETE. The chemical reactions and pathways involving the catabolism of aromatic amino acids to produce aromatic alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanol, 4-hydroxyphenylethanol, or tryptophol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.”
- database_cross_reference “GOC:krc”
- database_cross_reference “PMID:18281432”
aromatic amino acid family catabolic process to alcohol via Ehrlich pathway deprecated true
aromatic amino acid family catabolic process to alcohol via Ehrlich pathway comment “This term was obsoleted because it represents multiple specific pathways. Consider specific amino acid catabolic processes.”
aromatic amino acid family catabolic process to alcohol via Ehrlich pathway label “obsolete aromatic amino acid family catabolic process to alcohol via Ehrlich pathway”

aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway definition “The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanoate, 4-hydroxyphenylethanoate, or 2-(Indol-3-yl)-ethanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.”
- database_cross_reference “GOC:krc”
- database_cross_reference “PMID:18281432”
aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway label “aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway”
aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway SubClassOf amino acid catabolic process to carboxylic acid via Ehrlich pathway
aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway SubClassOf aromatic amino acid family catabolic process

aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway term tracker item “https://github.com/geneontology/go-ontology/issues/31839”^^anyURI
aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway consider L-phenylalanine catabolic process
aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway consider L-tryptophan catabolic process
aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway consider L-tyrosine catabolic process
aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway definition “OBSOLETE. The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanoate, 4-hydroxyphenylethanoate, or 2-(Indol-3-yl)-ethanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.”
- database_cross_reference “GOC:krc”
- database_cross_reference “PMID:18281432”
aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway deprecated true
aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway comment “This term was obsoleted because it represents multiple specific pathways. Consider specific amino acid catabolic processes.”
aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway label “obsolete aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway”

asparagine metabolic process definition “The chemical reactions and pathways involving asparagine, 2-amino-3-carbamoylpropanoic acid.”
- database_cross_reference “GOC:curators”
asparagine metabolic process label “asparagine metabolic process”
asparagine metabolic process SubClassOf carboxylic acid metabolic process

aspartate family amino acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine.”
- database_cross_reference “GOC:ai”

aspartate family amino acid biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/32000”^^anyURI
aspartate family amino acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of L-aspartate or any of the amino acids synthesised from it (L-asparagine, L-lysine, L-methionine, L-threonine and L-isoleucine).”
- database_cross_reference “GOC:curators”

atrazine catabolic process to cyanuric acid term tracker item “https://github.com/geneontology/go-ontology/issues/31766”^^anyURI
atrazine catabolic process to cyanuric acid term replaced by atrazine catabolic process
atrazine catabolic process to cyanuric acid definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into cyanuric acid.”
- database_cross_reference “GOC:jl”
atrazine catabolic process to cyanuric acid deprecated true
atrazine catabolic process to cyanuric acid comment “The reason for obsoletion is that this term represents a GO-CAM model.”
atrazine catabolic process to cyanuric acid label “obsolete atrazine catabolic process to cyanuric acid”

atrazine catabolic process to isopropylamine term tracker item “https://github.com/geneontology/go-ontology/issues/31766”^^anyURI
atrazine catabolic process to isopropylamine term replaced by atrazine catabolic process
atrazine catabolic process to isopropylamine definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into isopropylamine.”
- database_cross_reference “GOC:jl”
atrazine catabolic process to isopropylamine deprecated true
atrazine catabolic process to isopropylamine comment “The reason for obsoletion is that this term represents a GO-CAM model.”
atrazine catabolic process to isopropylamine label “obsolete atrazine catabolic process to isopropylamine”

atrazine catabolic process to urea term tracker item “https://github.com/geneontology/go-ontology/issues/31766”^^anyURI
atrazine catabolic process to urea term replaced by atrazine catabolic process
atrazine catabolic process to urea definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into urea.”
- database_cross_reference “GOC:jl”
atrazine catabolic process to urea deprecated true
atrazine catabolic process to urea comment “The reason for obsoletion is that this term represents a GO-CAM model.”
atrazine catabolic process to urea label “obsolete atrazine catabolic process to urea”

autophagosome-membrane adaptor activity definition “The binding activity of a molecule that brings together a target membrane and an autophagosome during autophagy.”
- database_cross_reference “PMID:36635405”
- database_cross_reference “PMID:30544615”
autophagosome-membrane adaptor activity SubClassOf protein-membrane adaptor activity

autophagosome-membrane adaptor activity term tracker item “https://github.com/geneontology/go-ontology/issues/31866”^^anyURI
autophagosome-membrane adaptor activity definition “The binding activity of a molecule that brings together a target membrane and an autophagosome membrane during autophagy.”
- database_cross_reference “PMID:36635405”
- database_cross_reference “PMID:30544615”
autophagosome-membrane adaptor activity SubClassOf membrane-membrane adaptor activity

benzene 1,2-dioxygenase activity definition “Catalysis of the reaction: benzene + H+ + NADH + O2 = cis-cyclohexa-3,5-diene-1,2-diol + NAD+.”
- database_cross_reference “EC:1.14.12.3”
- database_cross_reference “RHEA:13813”

benzene 1,2-dioxygenase activity definition “Catalysis of the reaction: benzene + NADH + O2 + H+ = cis-1,2-dihydrobenzene-1,2-diol + NAD+.”
- database_cross_reference “RHEA:13813”

benzoate 1,2-dioxygenase activity definition “Catalysis of the reaction: benzoate + NADH + H+ + O2 = catechol + CO2 + NAD+.”
- database_cross_reference “EC:1.14.12.10”

benzoate 1,2-dioxygenase activity definition “Catalysis of the reaction: benzoate + NADH + O2 + H+ = (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD+.”
- database_cross_reference “RHEA:12633”

beta-alanine metabolic process database_cross_reference “Wikipedia:Beta-alanine”
beta-alanine metabolic process definition “The chemical reactions and pathways involving beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins.”
- database_cross_reference “GOC:jl”
- database_cross_reference “ISBN:0198506732”
beta-alanine metabolic process label “beta-alanine metabolic process”
beta-alanine metabolic process SubClassOf non-proteinogenic amino acid metabolic process

beta-alanine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI
beta-alanine metabolic process consider beta-alanine biosynthetic process
beta-alanine metabolic process consider beta-alanine catabolic process
beta-alanine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins.”
- database_cross_reference “GOC:jl”
- database_cross_reference “ISBN:0198506732”
beta-alanine metabolic process deprecated true
beta-alanine metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
beta-alanine metabolic process label “obsolete beta-alanine metabolic process”

biphenyl 2,3-dioxygenase activity definition “Catalysis of the reaction: biphenyl + NADH + H+ + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+. This reaction requires Fe2+.”
- database_cross_reference “EC:1.14.12.18”

biphenyl 2,3-dioxygenase activity definition “Catalysis of the reaction: biphenyl + NADH + H+ + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+. This reaction requires Fe2+.”
- database_cross_reference “RHEA:18165”

branched-chain amino acid catabolic process to alcohol via Ehrlich pathway definition “The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanol, 2-methylbutanol, or 2-methylpropanol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.”
- database_cross_reference “GOC:krc”
- database_cross_reference “PMID:18281432”
branched-chain amino acid catabolic process to alcohol via Ehrlich pathway label “branched-chain amino acid catabolic process to alcohol via Ehrlich pathway”
branched-chain amino acid catabolic process to alcohol via Ehrlich pathway SubClassOf amino acid catabolic process to alcohol via Ehrlich pathway
branched-chain amino acid catabolic process to alcohol via Ehrlich pathway SubClassOf branched-chain amino acid catabolic process

branched-chain amino acid catabolic process to alcohol via Ehrlich pathway term tracker item “https://github.com/geneontology/go-ontology/issues/31839”^^anyURI
branched-chain amino acid catabolic process to alcohol via Ehrlich pathway consider L-isoleucine catabolic process
branched-chain amino acid catabolic process to alcohol via Ehrlich pathway consider L-leucine catabolic process
branched-chain amino acid catabolic process to alcohol via Ehrlich pathway consider L-valine catabolic process
branched-chain amino acid catabolic process to alcohol via Ehrlich pathway definition “OBSOLETE. The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanol, 2-methylbutanol, or 2-methylpropanol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.”
- database_cross_reference “GOC:krc”
- database_cross_reference “PMID:18281432”
branched-chain amino acid catabolic process to alcohol via Ehrlich pathway deprecated true
branched-chain amino acid catabolic process to alcohol via Ehrlich pathway comment “This term was obsoleted because it represents multiple specific pathways. Consider specific amino acid catabolic processes.”
branched-chain amino acid catabolic process to alcohol via Ehrlich pathway label “obsolete branched-chain amino acid catabolic process to alcohol via Ehrlich pathway”

branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway definition “The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanoate, 2-methylbutanoate, or 2-methylpropanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.”
- database_cross_reference “GOC:krc”
- database_cross_reference “PMID:18281432”
branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway label “branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway”
branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway SubClassOf amino acid catabolic process to carboxylic acid via Ehrlich pathway
branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway SubClassOf branched-chain amino acid catabolic process

branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway term tracker item “https://github.com/geneontology/go-ontology/issues/31839”^^anyURI
branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway consider L-isoleucine catabolic process
branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway consider L-leucine catabolic process
branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway consider L-valine catabolic process
branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway definition “OBSOLETE. The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanoate, 2-methylbutanoate, or 2-methylpropanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.”
- database_cross_reference “GOC:krc”
- database_cross_reference “PMID:18281432”
branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway deprecated true
branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway comment “This term was obsoleted because it represents multiple specific pathways. Consider specific amino acid catabolic processes.”
branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway label “obsolete branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway”

butyrate-acetoacetate CoA-transferase activity definition “Catalysis of the reaction: acetoacetate + butanoyl-CoA = acetoacetyl-CoA + butanoate.”
- database_cross_reference “RHEA:12961”
- database_cross_reference “EC:2.8.3.9”

butyrate-acetoacetate CoA-transferase activity definition “Catalysis of the reaction: acetoacetate + butanoyl-CoA = acetoacetyl-CoA + butanoate.”
- database_cross_reference “RHEA:12961”

catecholamine transport definition “The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.”
- database_cross_reference “GOC:ai”
- database_cross_reference “ISBN:0198506732”
catecholamine transport label “catecholamine transport”
catecholamine transport SubClassOf monoamine transport
catecholamine transport SubClassOf organic hydroxy compound transport

catecholamine transport term tracker item “https://github.com/geneontology/go-ontology/issues/31143”^^anyURI
catecholamine transport definition “OBSOLETE. The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.”
- database_cross_reference “GOC:ai”
- database_cross_reference “ISBN:0198506732”
catecholamine transport deprecated true
catecholamine transport comment “The reason for obsoletion is that this is an unnecessary grouping term and annotations should be made to more mechanism/location specific terms.”
catecholamine transport label “obsolete catecholamine transport”

chloroplast targeting sequence binding definition “Binding to a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast.”
- database_cross_reference “GOC:mah”
chloroplast targeting sequence binding label “chloroplast targeting sequence binding”

chloroplast targeting sequence binding term tracker item “https://github.com/geneontology/go-ontology/issues/31419”^^anyURI
chloroplast targeting sequence binding has_narrow_synonym “chloroplast targeting sequence binding”
chloroplast targeting sequence binding definition “Binding to a chloroplast targeting sequence, a short stretch of amino acids found in a protein that acts as a signal to localize the protein to the chloroplast.”
- database_cross_reference “PMID:35929083”
chloroplast targeting sequence binding label “chloroplast targeting sequence receptor activity”

ciliary basal body-plasma membrane docking created by “pr”
ciliary basal body-plasma membrane docking creation date “2016-08-05T16:12:33Z”
ciliary basal body-plasma membrane docking has_exact_synonym “ciliary basal body docking”
ciliary basal body-plasma membrane docking has_related_synonym “anchoring of the basal body to the plasma membrane”
ciliary basal body-plasma membrane docking definition “The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane.”
- database_cross_reference “PMID:25686250”
- database_cross_reference “GOC:cilia”
- database_cross_reference “PMID:26981235”
- database_cross_reference “PMID:23348840”
- database_cross_reference “PMID:23530209”
- database_cross_reference “PMID:13978319”
ciliary basal body-plasma membrane docking comment “Basal bodies in jawed vertebrates appear to first attach to a ciliary vesicle. It is unclear how specific this is to jawed vertebrates or if other organisms also employ this sequence. Some species like Giardia intestinalis do not relocate their basal bodies to the plasma membrane, but have their axonemes extend through the cytosol to then protrude out of the cell to form flagella.”
ciliary basal body-plasma membrane docking label “ciliary basal body-plasma membrane docking”
ciliary basal body-plasma membrane docking SubClassOf organelle localization by membrane tethering
ciliary basal body-plasma membrane docking SubClassOf part of some cilium assembly

ciliary basal body-plasma membrane docking term tracker item “https://github.com/geneontology/go-ontology/issues/31882”^^anyURI
ciliary basal body-plasma membrane docking term replaced by ciliary transition zone assembly
ciliary basal body-plasma membrane docking definition “OBSOLETE. The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane.”
- database_cross_reference “PMID:25686250”
- database_cross_reference “GOC:cilia”
- database_cross_reference “PMID:26981235”
- database_cross_reference “PMID:23348840”
- database_cross_reference “PMID:23530209”
- database_cross_reference “PMID:13978319”
ciliary basal body-plasma membrane docking deprecated true
ciliary basal body-plasma membrane docking comment “The reason for obsoletion is that this term is redundant with GO:1905349 ciliary transition zone assembly. Per PMID:27646273, transition zone assembly is a complex process that begins with docking of the mother centriole to cytoplasmic vesicles, so the docking step is encompassed by transition zone assembly.”
ciliary basal body-plasma membrane docking label “obsolete ciliary basal body-plasma membrane docking”

ciliary transition fiber assembly term tracker item “https://github.com/geneontology/go-ontology/issues/31882”^^anyURI
ciliary transition fiber assembly term replaced by ciliary transition zone assembly
ciliary transition fiber assembly definition “OBSOLETE. The aggregation, arrangement and bonding together of a set of components to form a ciliary transition fiber.”
- database_cross_reference “GOC:cilia”
- database_cross_reference “PMID:24189274”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “GO_REF:0000079”
ciliary transition fiber assembly deprecated true
ciliary transition fiber assembly comment “The reason for obsoletion is that this term is redundant with GO:1905349 ciliary transition zone assembly. Ciliary transition fiber assembly is part of transition zone assembly and the term had no annotations.”
ciliary transition fiber assembly label “obsolete ciliary transition fiber assembly”

cinnamoyl-CoA:phenyllactate CoA-transferase activity definition “Catalysis of the reaction: (R)-3-phenyllactate + [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonatooxy)oxolan-2-yl]methyl {[(3R)-3-hydroxy-2,2-dimethyl-3-({2-[(2-{[(2E)-3-phenylprop-2-enoyl]sulfanyl}ethyl)carbamoyl]ethyl}carbamoyl)propyl phosphonato]oxy}phosphonate = (R)-3-phenyllactoyl-CoA + trans-cinnamate.”
- database_cross_reference “RHEA:15601”
- database_cross_reference “EC:2.8.3.17”

cinnamoyl-CoA:phenyllactate CoA-transferase activity definition “Catalysis of the reaction: (E)-cinnamoyl-CoA + (R)-3-phenyllactate = (R)-3-phenyllactoyl-CoA + (E)-cinnamate.”
- database_cross_reference “RHEA:15601”

citramalate CoA-transferase activity definition “Catalysis of the reaction: acetyl-CoA + citramalate = acetate + (3S)-citramalyl-CoA.”
- database_cross_reference “MetaCyc:CITRAMALATE-COA-TRANSFERASE-RXN”
- database_cross_reference “EC:2.8.3.11”

citramalate CoA-transferase activity definition “Catalysis of the reaction: citramalate + acetyl-CoA = (3S)-citramalyl-CoA + acetate.”
- database_cross_reference “RHEA:17621”

citrate CoA-transferase activity definition “Catalysis of the reaction: acetyl-CoA + citrate = acetate + (3S)-citryl-CoA.”
- database_cross_reference “EC:2.8.3.10”

citrate CoA-transferase activity definition “Catalysis of the reaction: acetyl-CoA + citrate = acetate + (3S)-citryl-CoA.”
- database_cross_reference “RHEA:19405”

citrulline biosynthetic process definition “The chemical reactions and pathways resulting in the formation of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins.”
- database_cross_reference “ISBN:0198506732”
citrulline biosynthetic process label “citrulline biosynthetic process”
citrulline biosynthetic process SubClassOf citrulline metabolic process
citrulline biosynthetic process SubClassOf alpha-amino acid biosynthetic process

citrulline biosynthetic process has_broad_synonym “citrulline biosynthetic process”
citrulline biosynthetic process definition “The chemical reactions and pathways resulting in the formation of L-citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins.”
- database_cross_reference “ISBN:0198506732”
citrulline biosynthetic process label “L-citrulline biosynthetic process”
citrulline biosynthetic process SubClassOf amino acid biosynthetic process

citrulline metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI
citrulline metabolic process consider citrulline biosynthetic process
citrulline metabolic process consider L-citrulline catabolic process
citrulline metabolic process definition “OBSOLETE. The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins.”
- database_cross_reference “ISBN:0198506732”
citrulline metabolic process deprecated true
citrulline metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
citrulline metabolic process label “obsolete citrulline metabolic process”

contractile vacuole tethering involved in discharge term tracker item “https://github.com/geneontology/go-ontology/issues/31870”^^anyURI
contractile vacuole tethering involved in discharge term replaced by contractile vacuole-plasma membrane tether activity
contractile vacuole tethering involved in discharge definition “OBSOLETE. The initial, indirect interaction between a contractile vacuole membrane and a site of discharge in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion.”
- database_cross_reference “PMID:22323285”
contractile vacuole tethering involved in discharge deprecated true
contractile vacuole tethering involved in discharge comment “Obsoleted because this term describes a molecular function (tethering activity) rather than a biological process. Replaced by the molecular_function term GO:7770067 contractile vacuole-plasma membrane tether activity.”
contractile vacuole tethering involved in discharge label “obsolete contractile vacuole tethering involved in discharge”

cysteine export across plasma membrane definition “The directed movement of cysteine from inside of a cell, across the plasma membrane and into the extracellular region.”
- database_cross_reference “GOC:mlg”
cysteine export across plasma membrane label “cysteine export across plasma membrane”

cysteine export across plasma membrane term tracker item “https://github.com/geneontology/go-ontology/issues/27479”^^anyURI
cysteine export across plasma membrane has_broad_synonym “L-cysteine export”
cysteine export across plasma membrane has_broad_synonym “cysteine export across plasma membrane”
cysteine export across plasma membrane definition “The directed movement of L-cysteine from inside of a cell, across the plasma membrane and into the extracellular region.”
- database_cross_reference “GOC:mlg”
cysteine export across plasma membrane label “L-cysteine export across plasma membrane”

cysteine transmembrane transporter activity definition “Enables the transfer of cysteine from one side of a membrane to the other.”
- database_cross_reference “GOC:mah”
cysteine transmembrane transporter activity label “cysteine transmembrane transporter activity”

cysteine transport has_narrow_synonym “L-cysteine transport”
cysteine transport definition “The directed movement of cysteine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:jl”
- database_cross_reference “ISBN:0198506732”
cysteine transport label “cysteine transport”
cysteine transport SubClassOf organic cation transport

cysteine transport has_broad_synonym “cysteine transport”
cysteine transport definition “The directed movement of L-cysteine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:jl”
- database_cross_reference “ISBN:0198506732”
cysteine transport label “L-cysteine transport”
cysteine transport SubClassOf L-amino acid transport

cysteinyl-tRNA aminoacylation definition “The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2’-OH group of a cysteine-accetping tRNA. The 2’-O-aminoacyl-tRNA will ultimately migrate to the 3’ position via transesterification.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”

cysteinyl-tRNA aminoacylation definition “The process of coupling L-cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2’-OH group of a cysteine-accepting tRNA. The 2’-O-aminoacyl-tRNA will ultimately migrate to the 3’ position via transesterification.”
- database_cross_reference “GOC:mcc”
- database_cross_reference “ISBN:0716730510”

cytoskeletal anchor activity term tracker item “https://github.com/geneontology/go-ontology/issues/19185”^^anyURI
cytoskeletal anchor activity has_narrow_synonym “cytoskeletal anchor activity”
cytoskeletal anchor activity label “cytoskeletal adaptor activity”

denatured protein binding definition “Binding to a denatured protein.”
- database_cross_reference “GOC:mlg”
denatured protein binding comment “Note that this term should not be confused with ‘unfolded protein binding ; GO:0051082’, which usually refers to proteins that have not yet folded into their active states. Denatured proteins once were in their correct functional conformations, but have become incorrectly folded, and often form aggregates.”
denatured protein binding label “denatured protein binding”
denatured protein binding SubClassOf protein binding

denatured protein binding term tracker item “https://github.com/geneontology/go-ontology/issues/30962”^^anyURI
denatured protein binding consider protein folding chaperone
denatured protein binding consider unfolded protein holdase activity
denatured protein binding definition “OBSOLETE. Binding to a denatured protein.”
- database_cross_reference “GOC:mlg”
denatured protein binding deprecated true
denatured protein binding comment “The reason for obsoletion is that this binding term should be replaced by an activity term such as protein folding chaperone (GO:0044183) or unfolded protein holdase activity (GO:0140309).”
denatured protein binding label “obsolete denatured protein binding”

development of secondary female sexual characteristics definition “The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female humans, these include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion.”
- database_cross_reference “GOC:ai”
development of secondary female sexual characteristics label “development of secondary female sexual characteristics”

development of secondary female sexual characteristics term tracker item “https://github.com/geneontology/go-ontology/issues/31051”^^anyURI
development of secondary female sexual characteristics has_exact_synonym “development of secondary female sexual characteristics”
development of secondary female sexual characteristics has_exact_synonym “development of secondary female sexual characteristics, sensu Metazoa”
development of secondary female sexual characteristics definition “The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female mammals, examples include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion.”
- database_cross_reference “GOC:ai”
development of secondary female sexual characteristics label “development of animal secondary female sexual characteristics”

development of secondary male sexual characteristics definition “The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male humans, these include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion.”
- database_cross_reference “GOC:ai”
development of secondary male sexual characteristics label “development of secondary male sexual characteristics”

development of secondary male sexual characteristics term tracker item “https://github.com/geneontology/go-ontology/issues/31051”^^anyURI
development of secondary male sexual characteristics has_exact_synonym “development of secondary male sexual characteristics”
development of secondary male sexual characteristics has_exact_synonym “development of secondary male sexual characteristics, sensu Metazoa”
development of secondary male sexual characteristics definition “The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male mammals, examples include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion.”
- database_cross_reference “GOC:ai”
development of secondary male sexual characteristics label “development of animal secondary male sexual characteristics”

development of secondary sexual characteristics definition “The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In humans, these include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion.”
- database_cross_reference “GOC:ai”
development of secondary sexual characteristics label “development of secondary sexual characteristics”

development of secondary sexual characteristics term tracker item “https://github.com/geneontology/go-ontology/issues/31051”^^anyURI
development of secondary sexual characteristics has_exact_synonym “development of secondary sexual characteristics”
development of secondary sexual characteristics has_exact_synonym “development of secondary sexual characteristics, sensu Metazoa”
development of secondary sexual characteristics definition “The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In mammals, examples include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion.”
- database_cross_reference “GOC:ai”
development of secondary sexual characteristics label “development of animal secondary sexual characteristics”

dibenzofuran 4,4a-dioxygenase activity definition “Catalysis of the reaction: dibenzofuran + NADH + H+ + O2 = 2,2’,3-trihydroxybiphenyl + NAD+.”
- database_cross_reference “MetaCyc:R606-RXN”
- database_cross_reference “RHEA:42460”

dibenzofuran 4,4a-dioxygenase activity definition “Catalysis of the reaction: dibenzofuran + NADH + H+ + O2 = 2,2’,3-trihydroxybiphenyl + NAD+.”
- database_cross_reference “RHEA:42460”

dopamine transport definition “The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.”
- database_cross_reference “GOC:ai”
dopamine transport label “dopamine transport”
dopamine transport SubClassOf catecholamine transport

dopamine transport term tracker item “https://github.com/geneontology/go-ontology/issues/31143”^^anyURI
dopamine transport definition “OBSOLETE. The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.”
- database_cross_reference “GOC:ai”
dopamine transport deprecated true
dopamine transport comment “The reason for obsoletion is that this is an unnecessary grouping term and annotations should be made to more mechanism/location specific terms.”
dopamine transport label “obsolete dopamine transport”

early endosome to late endosome transport definition “The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs.”
- database_cross_reference “PMID:29980602”
- database_cross_reference “ISBN:0815316194”

early endosome to late endosome transport term tracker item “https://github.com/geneontology/go-ontology/issues/31923”^^anyURI
early endosome to late endosome transport definition “The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes.”
- database_cross_reference “PMID:29980602”
- database_cross_reference “ISBN:0815316194”

endocrine hormone secretion term tracker item “https://github.com/geneontology/go-ontology/issues/17084”^^anyURI
endocrine hormone secretion term replaced by hormone secretion
endocrine hormone secretion definition “OBSOLETE. The regulated release of a hormone into the circulatory system.”
- database_cross_reference “GOC:dph”
endocrine hormone secretion deprecated true
endocrine hormone secretion comment “The reason for obsoletion is that this term represents fake precision. The distinction between endocrine and other modes of hormone dispersal (paracrine, autocrine) is not always clear-cut, and this term was unevenly used relative to its parent.”
endocrine hormone secretion label “obsolete endocrine hormone secretion”

endoplasmic reticulum signal peptide binding definition “Binding to an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum.”
- database_cross_reference “GOC:mah”
endoplasmic reticulum signal peptide binding label “endoplasmic reticulum signal peptide binding”

endoplasmic reticulum signal peptide binding term tracker item “https://github.com/geneontology/go-ontology/issues/31419”^^anyURI
endoplasmic reticulum signal peptide binding has_narrow_synonym “endoplasmic reticulum signal peptide binding”
endoplasmic reticulum signal peptide binding definition “Binding to an endoplasmic reticulum signal peptide, a short stretch of amino acids found in a protein that acts as a signal to localize the protein to the endoplasmic reticulum.”
- database_cross_reference “GOC:mah”
endoplasmic reticulum signal peptide binding label “endoplasmic reticulum signal sequence receptor activity”

endoplasmic reticulum-autophagosome adaptor activity definition “The binding activity of a molecule that brings together an ER membrane and an autophagosome during reticulophagy.”
- database_cross_reference “PMID:32735772”

endoplasmic reticulum-autophagosome adaptor activity term tracker item “https://github.com/geneontology/go-ontology/issues/31866”^^anyURI
endoplasmic reticulum-autophagosome adaptor activity definition “The binding activity of a molecule that brings together an ER membrane and an autophagosome membrane during reticulophagy.”
- database_cross_reference “PMID:32735772”

endoplasmic reticulum-endosome tether activity definition “The binding activity of a molecule that brings together an endosome and an ER membrane either via membrane lipid binding or by interacting with an endosome protein, to establish and facilitate organelle exchange.”
- database_cross_reference “PMID:33124732”

endoplasmic reticulum-endosome tether activity term tracker item “https://github.com/geneontology/go-ontology/issues/31866”^^anyURI
endoplasmic reticulum-endosome tether activity definition “The binding activity of a molecule that brings together an endosome membrane and an ER membrane either via membrane lipid binding or by interacting with an endosome protein, to establish and facilitate organelle exchange.”
- database_cross_reference “PMID:33124732”

endoplasmic reticulum-peroxisome tethering term tracker item “https://github.com/geneontology/go-ontology/issues/31879”^^anyURI
endoplasmic reticulum-peroxisome tethering consider peroxisome-endoplasmic reticulum membrane tether activity
endoplasmic reticulum-peroxisome tethering definition “OBSOLETE. The attachment of an endoplasmic reticulum membrane to a peroxisome via molecular tethers that physically bridge the two membranes and attach them to each other.”
- database_cross_reference “PMID:28463579”
endoplasmic reticulum-peroxisome tethering deprecated true
endoplasmic reticulum-peroxisome tethering comment “The reason for obsoletion is that this term represents a molecular function rather than a biological process.”
endoplasmic reticulum-peroxisome tethering label “obsolete endoplasmic reticulum-peroxisome tethering”

endoplasmic reticulum-plasma membrane tethering term tracker item “https://github.com/geneontology/go-ontology/issues/31873”^^anyURI
endoplasmic reticulum-plasma membrane tethering consider endoplasmic reticulum localization
endoplasmic reticulum-plasma membrane tethering consider endoplasmic reticulum-plasma membrane adaptor activity
endoplasmic reticulum-plasma membrane tethering definition “OBSOLETE. The attachment of an endoplasmic reticulum membrane to the plasma membrane via molecular tethers.”
- database_cross_reference “GOC:dph”
- database_cross_reference “PMID:23237950”
- database_cross_reference “GOC:vw”
- database_cross_reference “PMID:27875684”
- database_cross_reference “PMID:26877082”
endoplasmic reticulum-plasma membrane tethering deprecated true
endoplasmic reticulum-plasma membrane tethering comment “This term was obsoleted because it represents a molecular function. Annotations should be migrated to GO:0160214 ‘endoplasmic reticulum-plasma membrane adaptor activity’; the biological process aspect (if any) is captured by GO:0051643 ‘endoplasmic reticulum localization’.”
endoplasmic reticulum-plasma membrane tethering label “obsolete endoplasmic reticulum-plasma membrane tethering”

epinephrine transport has_exact_synonym “adrenaline transport”
epinephrine transport definition “The directed movement of epinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:jid”
epinephrine transport label “epinephrine transport”
epinephrine transport SubClassOf organic cation transport
epinephrine transport SubClassOf catecholamine transport

epinephrine transport term tracker item “https://github.com/geneontology/go-ontology/issues/31143”^^anyURI
epinephrine transport definition “OBSOLETE. The directed movement of epinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:jid”
epinephrine transport deprecated true
epinephrine transport comment “The reason for obsoletion is that this is an unnecessary grouping term and annotations should be made to more mechanism/location specific terms.”
epinephrine transport label “obsolete epinephrine transport”

ergothioneine biosynthesis from histidine via hercynylcysteine sulfoxide synthase definition “A biosynthetic process that results in the formation of ergothioneine from histidine via a set of steps including the hercynylcysteine sulfoxide synthase reaction, which converts N-alpha,N-alpha,N-alpha-trimethyl-L-histidine directly to hercynylcysteine sulfoxide.”
- database_cross_reference “PMID:24828577”
- database_cross_reference “PMID:22209968”
ergothioneine biosynthesis from histidine via hercynylcysteine sulfoxide synthase label “ergothioneine biosynthesis from histidine via hercynylcysteine sulfoxide synthase”
ergothioneine biosynthesis from histidine via hercynylcysteine sulfoxide synthase SubClassOf ergothioneine biosynthetic process

ergothioneine metabolic process definition “The chemical reactions and pathways involving ergothioneine, a naturally occurring metabolite of histidine with antioxidant properties.”
- database_cross_reference “Wikipedia:Ergothioneine”
ergothioneine metabolic process label “ergothioneine metabolic process”
ergothioneine metabolic process SubClassOf sulfur amino acid metabolic process
ergothioneine metabolic process SubClassOf amino-acid betaine metabolic process

ergothioneine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI
ergothioneine metabolic process consider ergothioneine biosynthetic process
ergothioneine metabolic process consider ergothioneine catabolic process
ergothioneine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving ergothioneine, a naturally occurring metabolite of histidine with antioxidant properties.”
- database_cross_reference “Wikipedia:Ergothioneine”
ergothioneine metabolic process deprecated true
ergothioneine metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
ergothioneine metabolic process label “obsolete ergothioneine metabolic process”

erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of erythrose 4-phosphate/phosphoenolpyruvate family amino acid.”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “GOC:pr”

erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/32000”^^anyURI
erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of an L-amino acid derived from erythrose 4-phosphate and phosphoenolpyruvate (L-phenylalanine, L-tyrosine and L-tryptophan).”
- database_cross_reference “GOC:curators”

exocyst definition “A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals.”
- database_cross_reference “GOC:cilia”
- database_cross_reference “PMID:15292201”
- database_cross_reference “PMID:27243008”
- database_cross_reference “PMID:9700152”

exocyst term tracker item “https://github.com/geneontology/go-ontology/issues/31922”^^anyURI
exocyst definition “A vesicle tethering complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals.”
- database_cross_reference “GOC:cilia”
- database_cross_reference “PMID:15292201”
- database_cross_reference “PMID:27243008”
- database_cross_reference “PMID:9700152”

exocytic insertion of neurotransmitter receptor to plasma membrane term tracker item “https://github.com/geneontology/go-ontology/issues/31869”^^anyURI
exocytic insertion of neurotransmitter receptor to plasma membrane definition “OBSOLETE. The exocytic fusion of neurotransmitter receptor-containing vesicles with plasma membrane, resulting in the integration of neurotransmitter receptors into the plasma membrane. This process includes tethering and docking steps that prepare vesicles for fusion.”
- database_cross_reference “PMID:19503082”
- database_cross_reference “GOC:bc”
- database_cross_reference “GOC:aruk”
exocytic insertion of neurotransmitter receptor to plasma membrane deprecated true
exocytic insertion of neurotransmitter receptor to plasma membrane comment “The reason for obsoletion is that the meaning of the term is ambiguous. It was placed under both tethering and docking involved in exocytosis, but it is unclear which part of exocytosis it refers to, and it has not been used.”
exocytic insertion of neurotransmitter receptor to plasma membrane label “obsolete exocytic insertion of neurotransmitter receptor to plasma membrane”

extracellular region comment “Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term ‘extracellular space ; GO:0005615’.”

extracellular region term tracker item “https://github.com/geneontology/go-ontology/issues/31545”^^anyURI
extracellular region comment “Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products at the cell surface, consider annotating to external side of plasma membrane ; GO:0009897.”

ferric-chelate reductase activity definition “Catalysis of the reaction: 2 Fe3+-siderophore + electron donor = 2 Fe2+-siderophore + electron acceptor.”
- database_cross_reference “PMID:33559753”
ferric-chelate reductase activity SubClassOf oxidoreductase activity, acting on metal ions

ferric-chelate reductase activity term tracker item “https://github.com/geneontology/go-ontology/issues/27593”^^anyURI
ferric-chelate reductase activity definition “Catalysis of the reaction: 2 Fe3+-chelate + electron donor = 2 Fe2+-chelate + electron acceptor.”
- database_cross_reference “PMID:33559753”
ferric-chelate reductase activity SubClassOf ferric iron reductase activity

Class: ferritinophagy
ferritinophagy term tracker item “https://github.com/geneontology/go-ontology/issues/30894”^^anyURI
ferritinophagy created by “dragon-ai-agent”
ferritinophagy creation date “2026-04-29T15:27:39Z”
ferritinophagy has_exact_synonym “ferritin-specific autophagy”
ferritinophagy has_obo_namespace “biological_process”
ferritinophagy id “GO:7770069”
ferritinophagy definition “The selective degradation of ferritin to release iron by macroautophagy.”
- database_cross_reference “PMID:25327288”
- database_cross_reference “PMID:26436293”
- database_cross_reference “PMID:38714719”
ferritinophagy label “ferritinophagy”
ferritinophagy SubClassOf macroautophagy

formyl-CoA transferase activity definition “Catalysis of the reaction: formyl-CoA + oxalate = formate + oxalyl-CoA.”
- database_cross_reference “RHEA:16545”
- database_cross_reference “EC:2.8.3.16”

formyl-CoA transferase activity definition “Catalysis of the reaction: formyl-CoA + oxalate = formate + oxalyl-CoA.”
- database_cross_reference “RHEA:16545”

fungal-type cell wall disassembly involved in conjugation with cellular fusion definition “Any fungal-type cell wall disassembly that is involved in conjugation with cellular fusion.”
- database_cross_reference “GO_REF:0000060”
- database_cross_reference “PMID:25825517”
- database_cross_reference “GOC:TermGenie”
fungal-type cell wall disassembly involved in conjugation with cellular fusion label “fungal-type cell wall disassembly involved in conjugation with cellular fusion”

fungal-type cell wall disassembly involved in conjugation with cellular fusion term tracker item “https://github.com/geneontology/go-ontology/issues/31753”^^anyURI
fungal-type cell wall disassembly involved in conjugation with cellular fusion has_exact_synonym “fungal-type cell wall disassembly involved in conjugation with cellular fusion”
fungal-type cell wall disassembly involved in conjugation with cellular fusion definition “Any fungal-type cell wall disassembly that is involved in conjugation with cellular fusion, where the cell wall is locally disassembled to enable conjugation with cellular fusion.”
- database_cross_reference “GO_REF:0000060”
- database_cross_reference “PMID:25825517”
- database_cross_reference “GOC:TermGenie”
fungal-type cell wall disassembly involved in conjugation with cellular fusion label “mating projection tip cell wall disassembly”

galactonate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/28388”^^anyURI
galactonate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of galactonate, the anion of galactonic acid.”
- database_cross_reference “GOC:ai”
galactonate catabolic process label “galactonate catabolic process”
galactonate catabolic process SubClassOf aldonic acid catabolic process

geranylgeranyl diphosphate reductase activity definition “Catalysis of the reaction: (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + 3 NADP = 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + 3 NADPH + 3 H+.”
- database_cross_reference “GOC:pz”
- database_cross_reference “EC:1.3.1.83”

geranylgeranyl diphosphate reductase activity definition “Catalysis of the reaction: phytyl diphosphate + 3 NADP+ = geranylgeranyl diphosphate + 3 NADPH + 3 H+. This enzyme also catalyzes the reduction of geranylgeranyl-chlorophyll a into phytyl-chlorophyll a.”
- database_cross_reference “EC:1.3.1.83”
- database_cross_reference “PMID:9492312”
- database_cross_reference “RHEA:26229”

geranylgeranyl reductase activity definition “Catalysis of the formation of phytyl group from the stepwise reduction of a geranylgeranyl group.”
- database_cross_reference “PMID:9492312”
geranylgeranyl reductase activity label “geranylgeranyl reductase activity”
geranylgeranyl reductase activity SubClassOf oxidoreductase activity

geranylgeranyl reductase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31963”^^anyURI
geranylgeranyl reductase activity term replaced by geranylgeranyl diphosphate reductase activity
geranylgeranyl reductase activity definition “OBSOLETE. Catalysis of the formation of phytyl group from the stepwise reduction of a geranylgeranyl group.”
- database_cross_reference “PMID:9492312”
geranylgeranyl reductase activity deprecated true
geranylgeranyl reductase activity comment “This term was obsoleted because it lacked a proper enzyme cross-reference and is equivalent to GO:0102067 ‘geranylgeranyl diphosphate reductase activity’ (EC:1.3.1.83, RHEA:26229), which describes the same reaction (PMID:9492312: reduction of geranylgeranyl diphosphate to phytyl diphosphate, also acting on geranylgeranyl-chlorophyll a).”
geranylgeranyl reductase activity label “obsolete geranylgeranyl reductase activity”

glucarate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of glucarate, the anion of glucaric acid.”
- database_cross_reference “ISBN:0198506732”
glucarate biosynthetic process label “glucarate biosynthetic process”
glucarate biosynthetic process SubClassOf aldaric acid biosynthetic process

glucarate biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/27059”^^anyURI
glucarate biosynthetic process term replaced by D-glucarate biosynthetic process
glucarate biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of glucarate, the anion of glucaric acid.”
- database_cross_reference “ISBN:0198506732”
glucarate biosynthetic process deprecated true
glucarate biosynthetic process comment “This term was obsoleted because it represents the same process as D-glucarate biosynthetic process ; GO:0042837.”
glucarate biosynthetic process label “obsolete glucarate biosynthetic process”

glucosamine biosynthetic process label “glucosamine biosynthetic process”

glucosamine catabolic process label “glucosamine catabolic process”

glucosamine metabolic process label “glucosamine metabolic process”

glutaconate CoA-transferase activity definition “Catalysis of the reaction: acetyl-CoA + (E)-glutaconate = acetate + glutaconyl-1-CoA.”
- database_cross_reference “EC:2.8.3.12”

glutaconate CoA-transferase activity definition “Catalysis of the reaction: trans-glutaconate + acetyl-CoA = (2E)-glutaconyl-CoA + acetate.”
- database_cross_reference “RHEA:23208”

glutamate-cysteine ligase complex definition “An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine.”
- database_cross_reference “PMID:9675072”

glutamate-cysteine ligase complex definition “An enzyme complex that catalyzes the ligation of L-glutamate to L-cysteine, forming gamma-L-glutamyl-L-cysteine.”
- database_cross_reference “PMID:9675072”

glycolytic process via Entner-Doudoroff Pathway has_related_synonym “gluconate pathway”
glycolytic process via Entner-Doudoroff Pathway definition “A glycolytic process in which the glucose is catabolized to pyruvate by first entering the Entner-Doudoroff pathway to yield pyruvate and glyceraldehyde-3-phosphate. The glyceraldehyde-3-phosphate is subsequently converted to pyruvate by the core glycolytic enzymes.”
- database_cross_reference “GOC:dph”
- database_cross_reference “PMID:9657988”
glycolytic process via Entner-Doudoroff Pathway label “glycolytic process via Entner-Doudoroff Pathway”
glycolytic process via Entner-Doudoroff Pathway SubClassOf glycolytic process
glycolytic process via Entner-Doudoroff Pathway SubClassOf has part some Entner-Doudoroff pathway

glycolytic process via Entner-Doudoroff Pathway term tracker item “https://github.com/geneontology/go-ontology/issues/31916”^^anyURI
glycolytic process via Entner-Doudoroff Pathway term replaced by glycolytic process
glycolytic process via Entner-Doudoroff Pathway definition “OBSOLETE. A glycolytic process in which the glucose is catabolized to pyruvate by first entering the Entner-Doudoroff pathway to yield pyruvate and glyceraldehyde-3-phosphate. The glyceraldehyde-3-phosphate is subsequently converted to pyruvate by the core glycolytic enzymes.”
- database_cross_reference “GOC:dph”
- database_cross_reference “PMID:9657988”
glycolytic process via Entner-Doudoroff Pathway deprecated true
glycolytic process via Entner-Doudoroff Pathway comment “This term was obsoleted because the existing IEA annotations are better captured by the parent term GO:0006096 (glycolytic process); pathway variants are better represented as GO-CAMs rather than as nested ontology terms.”
glycolytic process via Entner-Doudoroff Pathway label “obsolete glycolytic process via Entner-Doudoroff Pathway”

glycoprotein cargo receptor activity term tracker item “https://github.com/geneontology/go-ontology/issues/31038”^^anyURI
glycoprotein cargo receptor activity created by “dragon-ai-agent”
glycoprotein cargo receptor activity definition “Binding specifically to a glycoprotein (cargo) to deliver it to a transport vesicle. Glycoprotein cargo receptors span membranes, binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit the cargo molecules to nascent vesicles.”
- database_cross_reference “PMID:41203586”
glycoprotein cargo receptor activity label “glycoprotein cargo receptor activity”
glycoprotein cargo receptor activity SubClassOf cargo receptor activity

glycoprotein cargo receptor activity term tracker item “https://github.com/geneontology/go-ontology/issues/31948”^^anyURI
glycoprotein cargo receptor activity term replaced by cargo receptor activity
glycoprotein cargo receptor activity definition “OBSOLETE. Binding specifically to a glycoprotein (cargo) to deliver it to a transport vesicle. Glycoprotein cargo receptors span membranes, binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit the cargo molecules to nascent vesicles.”
- database_cross_reference “PMID:41203586”
glycoprotein cargo receptor activity deprecated true
glycoprotein cargo receptor activity comment “The reason for obsoletion is that this term was added in error. Most vesicle cargo are glycoproteins, so classifying cargo receptors by glycoprotein substrate introduces an additional, unhelpful axis of classification. Cargo receptor activities should instead be organized by transport domain (i.e., the vesicles they connect cargo to), with substrates captured via has_input.”
glycoprotein cargo receptor activity label “obsolete glycoprotein cargo receptor activity”

histamine oxidase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31964”^^anyURI

hydroxyquinol 1,2-dioxygenase activity term replaced by 4-hydroxycatechol 1,2-dioxygenase activity
hydroxyquinol 1,2-dioxygenase activity definition “OBSOLETE. Catalysis of the reaction: benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate + 2 H+.”
- database_cross_reference “RHEA:19441”
hydroxyquinol 1,2-dioxygenase activity deprecated true
hydroxyquinol 1,2-dioxygenase activity comment “The reason for obsoletion is that this term described a sub-reaction of the complete two-step reaction represented by GO:0047074. The second step (non-enzymatic conversion of 3-hydroxy-cis,cis-muconate to maleylacetate) is not catalyzed separately, so this term is equivalent to GO:0047074 hydroxyquinol 1,2-dioxygenase activity.”
hydroxyquinol 1,2-dioxygenase activity label “obsolete hydroxyquinol 1,2-dioxygenase activity”

hypoxanthine oxidase activity definition “Catalysis of the reaction: hypoxanthine + H2O + O2 = xanthine + H2O2.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:pde”

induction of conjugation with cellular fusion definition “The process in which a cell initiates conjugation with cellular fusion. Conjugation with cellular fusion is the process that results in the union of cellular and genetic information from compatible mating types.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:tb”
induction of conjugation with cellular fusion label “induction of conjugation with cellular fusion”
induction of conjugation with cellular fusion SubClassOf positive regulation of conjugation with cellular fusion

induction of conjugation with cellular fusion term tracker item “https://github.com/geneontology/go-ontology/issues/31335”^^anyURI
induction of conjugation with cellular fusion term replaced by positive regulation of conjugation with cellular fusion
induction of conjugation with cellular fusion definition “OBSOLETE. The process in which a cell initiates conjugation with cellular fusion. Conjugation with cellular fusion is the process that results in the union of cellular and genetic information from compatible mating types.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:tb”
induction of conjugation with cellular fusion deprecated true
induction of conjugation with cellular fusion comment “This term was obsoleted because it is a pre-composed term that should be represented as a GO-CAM model.”
induction of conjugation with cellular fusion label “obsolete induction of conjugation with cellular fusion”

intracellular cysteine homeostasis definition “A homeostatic process involved in the maintenance of a steady state level of cysteine within a cell.”
- database_cross_reference “PMID:19955263”

intracellular cysteine homeostasis definition “A homeostatic process involved in the maintenance of a steady state level of L-cysteine within a cell.”
- database_cross_reference “PMID:19955263”

ketogluconate biosynthetic process definition “The chemical reactions and pathways resulting in the formation of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group.”
- database_cross_reference “ISBN:0198506732”
ketogluconate biosynthetic process label “ketogluconate biosynthetic process”
ketogluconate biosynthetic process SubClassOf aldonic acid biosynthetic process

ketogluconate biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31978”^^anyURI
ketogluconate biosynthetic process term replaced by keto-D-gluconate biosynthetic process
ketogluconate biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group.”
- database_cross_reference “ISBN:0198506732”
ketogluconate biosynthetic process deprecated true
ketogluconate biosynthetic process comment “This term was obsoleted because it is an unnecessary grouping term.”
ketogluconate biosynthetic process label “obsolete ketogluconate biosynthetic process”

ketogluconate catabolic process definition “The chemical reactions and pathways resulting in the breakdown of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group.”
- database_cross_reference “ISBN:0198506732”
ketogluconate catabolic process label “ketogluconate catabolic process”
ketogluconate catabolic process SubClassOf aldonic acid catabolic process

ketogluconate catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31978”^^anyURI
ketogluconate catabolic process term replaced by keto-D-gluconate catabolic process
ketogluconate catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group.”
- database_cross_reference “ISBN:0198506732”
ketogluconate catabolic process deprecated true
ketogluconate catabolic process comment “This term was obsoleted because it represents an unnecessary grouping term.”
ketogluconate catabolic process label “obsolete ketogluconate catabolic process”

ketone body biosynthetic process definition “The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA.”
- database_cross_reference “ISBN:0198506732”
ketone body biosynthetic process SubClassOf ketone body metabolic process

ketone body biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31806”^^anyURI
ketone body biosynthetic process database_cross_reference “MetaCyc:PWY66-367”
ketone body biosynthetic process has_exact_synonym “ketogenesis”
ketone body biosynthetic process definition “The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA.”
- database_cross_reference “MetaCyc:PWY66-367”

ketone body catabolic process definition “The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA.”
- database_cross_reference “ISBN:0198506732”
ketone body catabolic process SubClassOf ketone body metabolic process

ketone body catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31806”^^anyURI
ketone body catabolic process definition “The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA.”
- database_cross_reference “MetaCyc:PWY66-367”

ketone body metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31806”^^anyURI
ketone body metabolic process definition “OBSOLETE. The chemical reactions and pathways involving ketone body.”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “GOC:pr”
ketone body metabolic process deprecated true
ketone body metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
ketone body metabolic process label “obsolete ketone body metabolic process”

lysine 2-monooxygenase activity label “lysine 2-monooxygenase activity”

malonate CoA-transferase activity definition “Catalysis of the reaction: acetyl-CoA + malonate = acetate + malonyl-CoA.”
- database_cross_reference “EC:2.8.3.3”
- database_cross_reference “RHEA:18817”

malonate CoA-transferase activity definition “Catalysis of the reaction: acetyl-CoA + malonate = acetate + malonyl-CoA.”
- database_cross_reference “RHEA:18817”

mating projection actin fusion focus definition “A focus at the mating projection tip where the cell wall is degraded during conjugation with cellular fusion. Actin filaments form an aster-like structure from this location.”
- database_cross_reference “PMID:25825517”

mating projection actin fusion focus term tracker item “https://github.com/geneontology/go-ontology/issues/31774”^^anyURI
mating projection actin fusion focus definition “A focus at the mating projection tip where the cell wall is degraded during cytogamy. Actin filaments form an aster-like structure from this location.”
- database_cross_reference “PMID:25825517”

membrane-membrane adaptor activity definition “The binding activity of a molecule that brings together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle.”
- database_cross_reference “GOC:curators”

membrane-membrane adaptor activity definition “The binding activity of a molecule that brings together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex, vesicle or organelle.”
- database_cross_reference “GOC:curators”

mitochondrial cysteinyl-tRNA aminoacylation definition “The process of coupling cysteine to cysteinyl-tRNA in a mitochondrion, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”

mitochondrial cysteinyl-tRNA aminoacylation definition “The process of coupling L-cysteine to cysteinyl-tRNA in a mitochondrion, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2’- or the 3’-hydroxyl group of the 3’-adenosine residue of the tRNA.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:mcc”

mitochondrial disulfide relay system definition “A protein folding process that facilitates the import of a subset of soluble proteins into mitochondrial intermembrane space via disulfide bond formation.”
- database_cross_reference “PMID:37159021”
- database_cross_reference “PMID:32936885”
mitochondrial disulfide relay system label “mitochondrial disulfide relay system”
mitochondrial disulfide relay system SubClassOf protein folding
mitochondrial disulfide relay system SubClassOf part of some protein import into mitochondrial intermembrane space

mitochondrial disulfide relay system term tracker item “https://github.com/geneontology/go-ontology/issues/31711”^^anyURI
mitochondrial disulfide relay system has_exact_synonym “mitochondrial disulfide relay system”
mitochondrial disulfide relay system has_narrow_synonym “CHCHD4/Mia40-dependent import”
mitochondrial disulfide relay system definition “The import of small cysteine-containing proteins from the cytosol across the outer mitochondrial membrane via the TOM complex driven by oxidative folding.”
- database_cross_reference “PMID:37159021”
- database_cross_reference “PMID:32936885”
mitochondrial disulfide relay system label “protein import into the intermembrane space via the disulfide relay system”
mitochondrial disulfide relay system SubClassOf protein import into mitochondrial intermembrane space

mitochondrial gene expression definition “The process in which a mitochondrial gene’s sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.”
- database_cross_reference “PMID:27058308”

mitochondrial gene expression term tracker item “https://github.com/geneontology/go-ontology/issues/31659”^^anyURI
mitochondrial gene expression definition “The process of transcribing and translating the mitochondrial genome (mtDNA) to produce at least a subset of oxidative phosphorylation (OXPHOS) proteins, 2 rRNAs, and mitochondrial tRNAs, which are critical for ATP production. Protein maturation is included when required to form an active form of a product from an inactive precursor form.”
- database_cross_reference “PMID:27058308”
- database_cross_reference “PMID:38117001”
- database_cross_reference “PMID:31861673”

mitochondrial tRNA wobble position uridine thiolation definition “The process in which a uridine residue at position 34 in the anticodon of a mitochondrial tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.”
- database_cross_reference “PMID:15509579”

mitochondrial tRNA wobble position uridine thiolation definition “The process in which a uridine residue at position 34 in the anticodon of a mitochondrial tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from L-cysteine to position C2 by several steps.”
- database_cross_reference “PMID:15509579”

mitochondrion autophagosome adaptor activity definition “The binding activity of a molecule that brings together a mitochondrial membrane and an autophagosome during mitophagy.”
- database_cross_reference “PMID:33138913”

mitochondrion autophagosome adaptor activity term tracker item “https://github.com/geneontology/go-ontology/issues/31866”^^anyURI
mitochondrion autophagosome adaptor activity definition “The binding activity of a molecule that brings together a mitochondrial membrane and an autophagosome membrane during mitophagy.”
- database_cross_reference “PMID:33138913”

mitochondrion-endoplasmic reticulum membrane tether activity definition “The binding activity of a molecule that brings together a mitochondrion and an ER membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion.”
- database_cross_reference “PMID:27875684”
- database_cross_reference “PMID:19556461”

mitochondrion-endoplasmic reticulum membrane tether activity term tracker item “https://github.com/geneontology/go-ontology/issues/31866”^^anyURI
mitochondrion-endoplasmic reticulum membrane tether activity definition “The binding activity of a molecule that brings together a mitochondrial outer membrane and an ER membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion.”
- database_cross_reference “PMID:27875684”
- database_cross_reference “PMID:19556461”

mitochondrion-endoplasmic reticulum membrane tethering term tracker item “https://github.com/geneontology/go-ontology/issues/31875”^^anyURI
mitochondrion-endoplasmic reticulum membrane tethering consider mitochondrion-endoplasmic reticulum membrane tether activity
mitochondrion-endoplasmic reticulum membrane tethering definition “OBSOLETE. The attachment of a mitochondrion and an endoplasmic reticulum via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles.”
- database_cross_reference “PMID:27875684”
- database_cross_reference “PMID:19556461”
mitochondrion-endoplasmic reticulum membrane tethering deprecated true
mitochondrion-endoplasmic reticulum membrane tethering comment “The reason for obsoletion is that this term represents a molecular function. Consider reannotating to GO:0140474 ‘mitochondrion-endoplasmic reticulum membrane tether activity’.”
mitochondrion-endoplasmic reticulum membrane tethering label “obsolete mitochondrion-endoplasmic reticulum membrane tethering”

mitochondrion-plasma membrane adaptor activity definition “The binding activity of a molecule that brings together a mitochondrion and a plasma membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion.”
- database_cross_reference “PMID:31582398”
mitochondrion-plasma membrane adaptor activity SubClassOf protein-membrane adaptor activity

mitochondrion-plasma membrane adaptor activity term tracker item “https://github.com/geneontology/go-ontology/issues/31866”^^anyURI
mitochondrion-plasma membrane adaptor activity definition “The binding activity of a molecule that brings together a mitochondrial outer membrane and a plasma membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion.”
- database_cross_reference “PMID:31582398”
mitochondrion-plasma membrane adaptor activity SubClassOf membrane-membrane adaptor activity

monoamine transport definition “The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:mah”
monoamine transport label “monoamine transport”
monoamine transport SubClassOf nitrogen compound transport

monoamine transport term tracker item “https://github.com/geneontology/go-ontology/issues/31143”^^anyURI
monoamine transport definition “OBSOLETE. The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.”
- database_cross_reference “GOC:mah”
monoamine transport deprecated true
monoamine transport comment “The reason for obsoletion is that this is an unnecessary grouping term and annotations should be made to more mechanism/location specific terms.”
monoamine transport label “obsolete monoamine transport”

negative regulation of L-dopa biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31703”^^anyURI
negative regulation of L-dopa biosynthetic process definition “OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of L-dopa biosynthetic process.”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:PARL”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “GO_REF:0000058”
negative regulation of L-dopa biosynthetic process deprecated true
negative regulation of L-dopa biosynthetic process comment “This term was obsoleted because there is no evidence that this process exists.”
negative regulation of L-dopa biosynthetic process label “obsolete negative regulation of L-dopa biosynthetic process”

negative regulation of butyryl-CoA catabolic process to butanol term tracker item “https://github.com/geneontology/go-ontology/issues/31933”^^anyURI
negative regulation of butyryl-CoA catabolic process to butanol definition “OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of butyryl-CoA catabolic process to butanol.”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “GOC:mengo_curators”
negative regulation of butyryl-CoA catabolic process to butanol deprecated true
negative regulation of butyryl-CoA catabolic process to butanol comment “This term was obsoleted because it is an unnecessary grouping term.”
negative regulation of butyryl-CoA catabolic process to butanol label “obsolete negative regulation of butyryl-CoA catabolic process to butanol”

negative regulation of nitric oxide mediated signal transduction term tracker item “https://github.com/geneontology/go-ontology/issues/26613”^^anyURI
negative regulation of nitric oxide mediated signal transduction term replaced by negative regulation of nitric oxide-cGMP mediated signal transduction
negative regulation of nitric oxide mediated signal transduction definition “OBSOLETE. Any process that decreases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO).”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:BHF”
negative regulation of nitric oxide mediated signal transduction deprecated true
negative regulation of nitric oxide mediated signal transduction comment “The reason for obsoletion is that this term has been inconsistently used and NO signaling proceeds via cGMP, so the more specific replacement term is preferred.”
negative regulation of nitric oxide mediated signal transduction label “obsolete negative regulation of nitric oxide mediated signal transduction”

nitric oxide dioxygenase NAD(P)H activity label “nitric oxide dioxygenase NAD(P)H activity”

nitric oxide dioxygenase NAD(P)H activity label “nitric oxide dioxygenase [NAD(P)H] activity”

nitric oxide mediated signal transduction has_exact_synonym “NO mediated signal transduction”
nitric oxide mediated signal transduction has_exact_synonym “NO-mediated signal transduction”
nitric oxide mediated signal transduction has_exact_synonym “nitric oxide-mediated signal transduction”
nitric oxide mediated signal transduction has_exact_synonym “nitric oxide signaling”
- database_cross_reference “GOC:bf”
nitric oxide mediated signal transduction definition “An intracellular signaling cassette that starts with production of nitric oxide, detection by receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and ends with the activation of downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:21549190”
nitric oxide mediated signal transduction label “nitric oxide mediated signal transduction”
nitric oxide mediated signal transduction SubClassOf intracellular signaling cassette

nitric oxide mediated signal transduction term tracker item “https://github.com/geneontology/go-ontology/issues/26613”^^anyURI
nitric oxide mediated signal transduction term replaced by nitric oxide-cGMP-mediated signaling
nitric oxide mediated signal transduction definition “OBSOLETE. An intracellular signaling cassette that starts with production of nitric oxide, detection by receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and ends with the activation of downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:21549190”
nitric oxide mediated signal transduction deprecated true
nitric oxide mediated signal transduction comment “The reason for obsoletion is that this term has been inconsistently used and NO signaling proceeds via cGMP, so the more specific replacement term is preferred.”
nitric oxide mediated signal transduction label “obsolete nitric oxide mediated signal transduction”

norepinephrine transport has_exact_synonym “levarterenol transport”
norepinephrine transport has_exact_synonym “noradrenaline transport”
norepinephrine transport definition “The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.”
- database_cross_reference “GOC:ai”
- database_cross_reference “ISBN:0198506732”
norepinephrine transport label “norepinephrine transport”
norepinephrine transport SubClassOf organic cation transport
norepinephrine transport SubClassOf catecholamine transport

norepinephrine transport term tracker item “https://github.com/geneontology/go-ontology/issues/31143”^^anyURI
norepinephrine transport definition “OBSOLETE. The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.”
- database_cross_reference “GOC:ai”
- database_cross_reference “ISBN:0198506732”
norepinephrine transport deprecated true
norepinephrine transport comment “The reason for obsoletion is that this is an unnecessary grouping term and annotations should be made to more mechanism/location specific terms.”
norepinephrine transport label “obsolete norepinephrine transport”

nucleotidase activity term tracker item “https://github.com/geneontology/go-ontology/issues/29439”^^anyURI
nucleotidase activity definition “Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate.”
- database_cross_reference “PMID:12947102”
- database_cross_reference “PMID:22555564”

obsolete glutamic-type endopeptidase activity definition “OBSOLETE. Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad.”
- database_cross_reference “GOC:mah”
- database_cross_reference “https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE”
- database_cross_reference “https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE”
obsolete glutamic-type endopeptidase activity deprecated true
obsolete glutamic-type endopeptidase activity comment “This term was obsoleted because it represents a specific substrate.”
obsolete glutamic-type endopeptidase activity label “obsolete glutamic-type endopeptidase activity”

obsolete glutamic-type endopeptidase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31893”^^anyURI
obsolete glutamic-type endopeptidase activity definition “Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad.”
- database_cross_reference “GOC:mah”
- database_cross_reference “https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE”
- database_cross_reference “https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE”
obsolete glutamic-type endopeptidase activity comment “Unobsoleted, since similar terms exist.”
obsolete glutamic-type endopeptidase activity label “glutamic-type endopeptidase activity”
obsolete glutamic-type endopeptidase activity SubClassOf endopeptidase activity
obsolete glutamic-type endopeptidase activity SubClassOf glutamic-type peptidase activity

old cell tip after activation of bipolar cell growth definition “A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs, which is part of a cell that has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:expert_jd”
old cell tip after activation of bipolar cell growth label “old cell tip after activation of bipolar cell growth”
old cell tip after activation of bipolar cell growth SubClassOf old growing cell tip

old cell tip after activation of bipolar cell growth term tracker item “https://github.com/geneontology/go-ontology/issues/31746”^^anyURI
old cell tip after activation of bipolar cell growth term replaced by old growing cell tip
old cell tip after activation of bipolar cell growth definition “OBSOLETE. A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs, which is part of a cell that has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures.”
- database_cross_reference “GOC:mah”
- database_cross_reference “GOC:expert_jd”
old cell tip after activation of bipolar cell growth deprecated true
old cell tip after activation of bipolar cell growth comment “This term was obsoleted because the parent process, activation of bipolar cell growth, GO:0051519, was obsoleted.”
old cell tip after activation of bipolar cell growth label “obsolete old cell tip after activation of bipolar cell growth”

organic acid biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31816”^^anyURI
organic acid biosynthetic process term replaced by metabolic process
organic acid biosynthetic process definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.”
- database_cross_reference “ISBN:0198506732”
organic acid biosynthetic process deprecated true
organic acid biosynthetic process comment “The reason for obsoletion is that this term was an unnecessary grouping term.”
organic acid biosynthetic process label “obsolete organic acid biosynthetic process”

organic acid catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31816”^^anyURI
organic acid catabolic process term replaced by metabolic process
organic acid catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.”
- database_cross_reference “ISBN:0198506732”
organic acid catabolic process deprecated true
organic acid catabolic process comment “The reason for obsoletion is that this term was an unnecessary grouping term.”
organic acid catabolic process label “obsolete organic acid catabolic process”

organic acid metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31816”^^anyURI
organic acid metabolic process term replaced by metabolic process
organic acid metabolic process definition “OBSOLETE. The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.”
- database_cross_reference “ISBN:0198506732”
organic acid metabolic process deprecated true
organic acid metabolic process comment “The reason for obsoletion is that this term was an unnecessary grouping term.”
organic acid metabolic process label “obsolete organic acid metabolic process”

organic acid phosphorylation term tracker item “https://github.com/geneontology/go-ontology/issues/31816”^^anyURI
organic acid phosphorylation term replaced by metabolic process
organic acid phosphorylation definition “OBSOLETE. The process of introducing one or more phosphate groups into an organic acid.”
- database_cross_reference “GOC:mah”
organic acid phosphorylation deprecated true
organic acid phosphorylation comment “The reason for obsoletion is that this term was an unnecessary grouping term.”
organic acid phosphorylation label “obsolete organic acid phosphorylation”

organic anion transport definition “The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.”
- database_cross_reference “GOC:krc”
- database_cross_reference “GOC:ai”
organic anion transport label “organic anion transport”
organic anion transport SubClassOf transport

organic anion transport term tracker item “https://github.com/geneontology/go-ontology/issues/30715”^^anyURI
organic anion transport term replaced by transmembrane transport
organic anion transport definition “OBSOLETE. The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.”
- database_cross_reference “GOC:krc”
- database_cross_reference “GOC:ai”
organic anion transport deprecated true
organic anion transport comment “The reason for obsoletion is that this term was an unnecessary grouping term.”
organic anion transport label “obsolete organic anion transport”

organic cation transport definition “The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage.”
- database_cross_reference “GOC:ai”
organic cation transport label “organic cation transport”
organic cation transport SubClassOf transport

organic cation transport term tracker item “https://github.com/geneontology/go-ontology/issues/30715”^^anyURI
organic cation transport term replaced by transmembrane transport
organic cation transport definition “OBSOLETE. The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage.”
- database_cross_reference “GOC:ai”
organic cation transport deprecated true
organic cation transport comment “The reason for obsoletion is that this term was an unnecessary grouping term.”
organic cation transport label “obsolete organic cation transport”

oxygen evolving activity relatedMatch RXN0-5265
oxygen evolving activity definition “Catalysis of the reaction: 2 H2O = O2 + 4 H+ + 4 e-. The evolution of oxygen from oxidizing water is carried out by the oxygen evolving complex in photosystem II of plants. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle.”
- database_cross_reference “GOC:kd”
- database_cross_reference “PMID:17091926”
- database_cross_reference “GOC:syr”
- database_cross_reference “PMID:7948862”
oxygen evolving activity SubClassOf oxidoreductase activity

oxygen evolving activity term tracker item “https://github.com/geneontology/go-ontology/issues/31592”^^anyURI
oxygen evolving activity definition “Catalysis of the reaction: 2 a plastoquinone + 4 hnu + 2 H2O = 2 a plastoquinol + O2. The evolution of oxygen from oxidizing water is carried out by the oxygen evolving complex in photosystem II of plants.”
- database_cross_reference “PMID:17091926”
- database_cross_reference “PMID:7948862”
- database_cross_reference “RHEA:36359”
oxygen evolving activity SubClassOf oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor

oxygen-dependent protoporphyrinogen oxidase activity label “oxygen-dependent protoporphyrinogen oxidase activity”

Class: p24 cargo receptor complex
p24 cargo receptor complex term tracker item “https://github.com/geneontology/go-ontology/issues/31295”^^anyURI
p24 cargo receptor complex created by “dragon-ai-agent”
p24 cargo receptor complex creation date “2026-05-06T17:36:35Z”
p24 cargo receptor complex has_exact_synonym “p24 complex”
p24 cargo receptor complex has_obo_namespace “cellular_component”
p24 cargo receptor complex has_related_synonym “Emp24-Erv25 complex”
p24 cargo receptor complex has_related_synonym “TMED complex”
p24 cargo receptor complex has_related_synonym “p24 family complex”
p24 cargo receptor complex id “GO:7770070”
p24 cargo receptor complex definition “A conserved, hetero-oligomeric (often tetrameric) cycling ER-Golgi protein complex that selectively recruits secretory cargo, especially GPI-anchored proteins, into COPII vesicles and helps maintain early secretory pathway organization. A functional p24 complex typically contains one member of each subfamily of p24 proteins, alpha, beta, gamma and delta.”
- database_cross_reference “PMID:32456004”
- database_cross_reference “PMID:34647572”
- database_cross_reference “PMID:19566487”
- database_cross_reference “PMID:26224213”
- database_cross_reference “PMID:27569046”
p24 cargo receptor complex label “p24 cargo receptor complex”
p24 cargo receptor complex SubClassOf cargo receptor complex

para-aminobenzoic acid metabolic process definition “The chemical reactions and pathways involving para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins.”
- database_cross_reference “PMID:11960743”
para-aminobenzoic acid metabolic process label “para-aminobenzoic acid metabolic process”
para-aminobenzoic acid metabolic process SubClassOf aromatic amino acid metabolic process
para-aminobenzoic acid metabolic process SubClassOf monocarboxylic acid metabolic process
para-aminobenzoic acid metabolic process SubClassOf benzene-containing compound metabolic process

para-aminobenzoic acid metabolic process consider 4-aminobenzoate biosynthetic process
para-aminobenzoic acid metabolic process definition “OBSOLETE. The chemical reactions and pathways involving para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins.”
- database_cross_reference “PMID:11960743”
para-aminobenzoic acid metabolic process deprecated true
para-aminobenzoic acid metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
para-aminobenzoic acid metabolic process label “obsolete para-aminobenzoic acid metabolic process”

peroxisome targeting sequence binding definition “Binding to a peroxisomal targeting sequence, a sequence of amino acids within a protein that acts as a signal for the localization of a protein into the peroxisome.”
- database_cross_reference “GOC:mah”
- database_cross_reference “ISBN:0879693568”
peroxisome targeting sequence binding label “peroxisome targeting sequence binding”

peroxisome targeting sequence binding term tracker item “https://github.com/geneontology/go-ontology/issues/31419”^^anyURI
peroxisome targeting sequence binding has_narrow_synonym “peroxisome targeting sequence binding”
peroxisome targeting sequence binding definition “Binding to a peroxisomal targeting sequence, a short stretch of amino acids found in a protein that acts as a signal to localize the protein to the peroxisome.”
- database_cross_reference “PMID:20659419”
peroxisome targeting sequence binding label “peroxisome signal sequence receptor activity”

peroxisome-chloroplast membrane tethering has_exact_synonym “attachment of peroxisome to chloroplast”
peroxisome-chloroplast membrane tethering definition “The attachment of a peroxisome to a chloroplast via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles.”
- database_cross_reference “PMID:17215364”
peroxisome-chloroplast membrane tethering label “peroxisome-chloroplast membrane tethering”
peroxisome-chloroplast membrane tethering SubClassOf organelle localization by membrane tethering

peroxisome-chloroplast membrane tethering term tracker item “https://github.com/geneontology/go-ontology/issues/31877”^^anyURI
peroxisome-chloroplast membrane tethering consider peroxisome-chloroplast membrane tether activity
peroxisome-chloroplast membrane tethering definition “OBSOLETE. The attachment of a peroxisome to a chloroplast via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles.”
- database_cross_reference “PMID:17215364”
peroxisome-chloroplast membrane tethering deprecated true
peroxisome-chloroplast membrane tethering comment “This term was made obsolete because it represents a molecular function rather than a biological process.”
peroxisome-chloroplast membrane tethering label “obsolete peroxisome-chloroplast membrane tethering”

peroxisome-endoplasmic reticulum membrane tether activity definition “The binding activity of a molecule that brings together a peroxisome and an ER membrane, either via membrane lipid binding or by interacting with a membrane protein.”
- database_cross_reference “PMID:39271061”

peroxisome-endoplasmic reticulum membrane tether activity term tracker item “https://github.com/geneontology/go-ontology/issues/31866”^^anyURI
peroxisome-endoplasmic reticulum membrane tether activity definition “The binding activity of a molecule that brings together a peroxisome membrane and an ER membrane, either via membrane lipid binding or by interacting with a membrane protein.”
- database_cross_reference “PMID:39271061”

peroxisome-mitochondrion membrane tether activity definition “The binding activity of a molecule that brings together the peroxisome and the mitochondrial outer membrane, establishing the localization of the peroxisome close to the mitochondrion.”
- database_cross_reference “PMID:38669296”
- database_cross_reference “PMID:29720625”
peroxisome-mitochondrion membrane tether activity SubClassOf protein-membrane adaptor activity

peroxisome-mitochondrion membrane tether activity term tracker item “https://github.com/geneontology/go-ontology/issues/31866”^^anyURI
peroxisome-mitochondrion membrane tether activity definition “The binding activity of a molecule that brings together the peroxisome membrane and the mitochondrial outer membrane, establishing the localization of the peroxisome close to the mitochondrion.”
- database_cross_reference “PMID:38669296”
- database_cross_reference “PMID:29720625”
peroxisome-mitochondrion membrane tether activity SubClassOf membrane-membrane adaptor activity

pheophorbide a oxygenase activity definition “Catalysis of the reaction: pheophorbide a + reduced ferredoxin + 2 O2 = red chlorophyll catabolite + oxidized ferredoxin + H2O.”
- database_cross_reference “PMID:14657372”
pheophorbide a oxygenase activity SubClassOf oxidoreductase activity, acting on iron-sulfur proteins as donors

phosphoglucomutase (glucose-cofactor) activity term tracker item “https://github.com/geneontology/go-ontology/issues/31927”^^anyURI
phosphoglucomutase (glucose-cofactor) activity definition “OBSOLETE. Catalysis of the reaction: glucose-1-phosphate = glucose-6-phosphate; using D-glucose as a cofactor.”
- database_cross_reference “EC:5.4.2.5”
phosphoglucomutase (glucose-cofactor) activity deprecated true
phosphoglucomutase (glucose-cofactor) activity comment “The reason for obsoletion is that this activity (EC:5.4.2.5) is not known to be catalyzed by any gene product. RHEA:23536, which is shared between EC:5.4.2.2 and EC:5.4.2.5, actually represents the EC:5.4.2.2 mechanism (alpha-D-glucose 1,6-bisphosphate-dependent) and remains as the exactMatch xref on the parent term GO:0004614 (phosphoglucomutase activity). EC:5.4.2.5 is retained on this obsolete term as the valid external reference.”
phosphoglucomutase (glucose-cofactor) activity label “obsolete phosphoglucomutase (glucose-cofactor) activity”

phthalate 4,5-dioxygenase activity definition “Catalysis of the reaction: H+ + NADH + O2 + phthalate = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD+.”
- database_cross_reference “EC:1.14.12.7”
- database_cross_reference “RHEA:17489”

phthalate 4,5-dioxygenase activity definition “Catalysis of the reaction: phthalate + NADH + O2 + H+ = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD+.”
- database_cross_reference “RHEA:17489”

piperitol synthase activity term tracker item “https://github.com/geneontology/go-ontology/issues/31969”^^anyURI
piperitol synthase activity definition “Catalysis of the reaction: (+)-pinoresinol + reduced [NADPH–hemoprotein reductase] + O2 = (+)-piperitol + oxidized [NADPH–hemoprotein reductase] + 2 H2O + H+. Also catalyzes the synthesis of (+)-sesamin from (+)-piperitol.”
- database_cross_reference “EC:1.14.19.74”
- database_cross_reference “PMID:16785429”
piperitol synthase activity SubClassOf oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

podosome term tracker item “https://github.com/geneontology/go-ontology/issues/20443”^^anyURI
podosome SubClassOf actin-based cell projection

polyamine deacetylation term tracker item “https://github.com/geneontology/go-ontology/issues/31741”^^anyURI
polyamine deacetylation consider polyamine catabolic process
polyamine deacetylation consider deacetylase activity
polyamine deacetylation definition “OBSOLETE. The modification of acetylpolyamine by the removal of acetyl groups.”
- database_cross_reference “PMID:28516954”
polyamine deacetylation deprecated true
polyamine deacetylation comment “The reason for obsoletion is that this term represents a molecular function.”
polyamine deacetylation label “obsolete polyamine deacetylation”

positive regulation of L-dopa biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31703”^^anyURI
positive regulation of L-dopa biosynthetic process definition “OBSOLETE. Any process that activates or increases the frequency, rate or extent of L-dopa biosynthetic process.”
- database_cross_reference “GOC:bf”
- database_cross_reference “PMID:16731528”
- database_cross_reference “GOC:PARL”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “GO_REF:0000058”
positive regulation of L-dopa biosynthetic process deprecated true
positive regulation of L-dopa biosynthetic process comment “This term was obsoleted because there is no evidence that this process exists.”
positive regulation of L-dopa biosynthetic process label “obsolete positive regulation of L-dopa biosynthetic process”

positive regulation of fatty acid beta-oxidation by octopamine signaling pathway term tracker item “https://github.com/geneontology/go-ontology/issues/32064”^^anyURI
positive regulation of fatty acid beta-oxidation by octopamine signaling pathway definition “OBSOLETE. An octopamine signaling pathway that results in positive regulation of fatty acid beta-oxidation.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:24120942”
- database_cross_reference “GO_REF:0000063”
- database_cross_reference “GOC:kmv”
positive regulation of fatty acid beta-oxidation by octopamine signaling pathway deprecated true
positive regulation of fatty acid beta-oxidation by octopamine signaling pathway comment “The reason for obsoletion is that this term represents a GO-CAM model (an upstream signaling event that positively regulates fatty acid beta-oxidation), which is better captured as a causal model in GO-CAM rather than as a standard GO term.”
positive regulation of fatty acid beta-oxidation by octopamine signaling pathway label “obsolete positive regulation of fatty acid beta-oxidation by octopamine signaling pathway”

positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway term tracker item “https://github.com/geneontology/go-ontology/issues/32064”^^anyURI
positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway definition “OBSOLETE. A serotonin receptor signaling pathway that results in positive regulation of fatty acid beta-oxidation.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “PMID:24120942”
- database_cross_reference “GO_REF:0000063”
- database_cross_reference “GOC:kmv”
positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway deprecated true
positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway comment “The reason for obsoletion is that this term represents a GO-CAM model (an upstream signaling event that positively regulates fatty acid beta-oxidation), which is better captured as a causal model in GO-CAM rather than as a standard GO term.”
positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway label “obsolete positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway”

positive regulation of nitric oxide mediated signal transduction term tracker item “https://github.com/geneontology/go-ontology/issues/26613”^^anyURI
positive regulation of nitric oxide mediated signal transduction term replaced by positive regulation of nitric oxide-cGMP mediated signal transduction
positive regulation of nitric oxide mediated signal transduction definition “OBSOLETE. Any process that increases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO).”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:BHF”
positive regulation of nitric oxide mediated signal transduction deprecated true
positive regulation of nitric oxide mediated signal transduction comment “The reason for obsoletion is that this term has been inconsistently used and NO signaling proceeds via cGMP, so the more specific replacement term is preferred.”
positive regulation of nitric oxide mediated signal transduction label “obsolete positive regulation of nitric oxide mediated signal transduction”

propionate CoA-transferase activity definition “Catalysis of the reaction: acetyl-CoA + propanoate = acetate + propanoyl-CoA.”
- database_cross_reference “EC:2.8.3.1”

propionate CoA-transferase activity definition “Catalysis of the reaction: acetyl-CoA + propanoate = acetate + propanoyl-CoA.”
- database_cross_reference “RHEA:23520”

propionyl-CoA:succinate CoA-transferase activity definition “Catalysis of the reaction: succinate + propionyl-CoA = succinyl-CoA + propionate.”
- database_cross_reference “PMID:10769117”

propionyl-CoA:succinate CoA-transferase activity definition “Catalysis of the reaction: succinate + propionyl-CoA = succinyl-CoA + propionate.”
- database_cross_reference “RHEA:28010”
- database_cross_reference “PMID:10769117”

protein O-linked glycosylation via N-acetyl-galactosamine label “protein O-linked glycosylation via N-acetyl-galactosamine”

protein carrier activity definition “Binding to and carrying a protein to an acceptor molecule or to a specific location by moving along with the target protein.”
- database_cross_reference “PMID:7628437”

protein carrier activity definition “Directly binding to a protein and delivering it either to an acceptor molecule or to a specific location.”
- database_cross_reference “PMID:7628437”

protein import into mitochondrial matrix term tracker item “/github.com/geneontology/go-ontology/issues/29962”^^anyURI
protein import into mitochondrial matrix definition “The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.”
- database_cross_reference “ISBN:0716731363”
protein import into mitochondrial matrix SubClassOf intercellular transport
protein import into mitochondrial matrix SubClassOf protein transmembrane transport
protein import into mitochondrial matrix SubClassOf establishment of protein localization to organelle

protein-macromolecule adaptor activity term tracker item “https://github.com/geneontology/go-ontology/issues/31444”^^anyURI
protein-macromolecule adaptor activity comment “Note that protein complex scaffolds should use GO:0140378 protein complex scaffold activity.”

protoporphyrinogen IX biosynthetic process from glutamate term tracker item “https://github.com/geneontology/go-ontology/issues/31788”^^anyURI
protoporphyrinogen IX biosynthetic process from glutamate definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glutamate.”
- database_cross_reference “PMID:32976912”
protoporphyrinogen IX biosynthetic process from glutamate deprecated true
protoporphyrinogen IX biosynthetic process from glutamate comment “This term was obsoleted because protoporphyrinogen IX is an intermediate in heme/chlorophyll/uroporphyrinogen biosynthesis.”
protoporphyrinogen IX biosynthetic process from glutamate label “obsolete protoporphyrinogen IX biosynthetic process from glutamate”

protoporphyrinogen IX metabolic process definition “The chemical reactions and pathways involving protoporphyrinogen IX, the specific substrate for the enzyme ferrochelatase, which catalyzes the insertion of iron to form protoheme. It is probably also the substrate for chlorophyll formation.”
- database_cross_reference “ISBN:0198506732”
protoporphyrinogen IX metabolic process comment “See also the molecular function term ‘ferrochelatase activity ; GO:0004325’.”
protoporphyrinogen IX metabolic process label “protoporphyrinogen IX metabolic process”
protoporphyrinogen IX metabolic process SubClassOf porphyrin-containing compound metabolic process

protoporphyrinogen IX metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31788”^^anyURI
protoporphyrinogen IX metabolic process definition “OBSOLETE. The chemical reactions and pathways involving protoporphyrinogen IX, the specific substrate for the enzyme ferrochelatase, which catalyzes the insertion of iron to form protoheme. It is probably also the substrate for chlorophyll formation.”
- database_cross_reference “ISBN:0198506732”
protoporphyrinogen IX metabolic process deprecated true
protoporphyrinogen IX metabolic process comment “This term was obsoleted because protoporphyrinogen IX is an intermediate in heme/chlorophyll/uroporphyrinogen biosynthesis.”
protoporphyrinogen IX metabolic process label “obsolete protoporphyrinogen IX metabolic process”

protoporphyrinogen oxidase activity definition “Catalysis of the reaction: protoporphyrinogen IX + acceptor = protoporphyrin IX + reduced acceptor.”
- database_cross_reference “GOC:mah”
- database_cross_reference “PMID:19583219”

putrescine biosynthetic process from arginine via N-carbamoylputrescine database_cross_reference “MetaCyc:PWY-43”
putrescine biosynthetic process from arginine via N-carbamoylputrescine definition “The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine, via the intermediate N-carbamoylputrescine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in two single enzymatic steps.”
- database_cross_reference “MetaCyc:PWY-43”
- database_cross_reference “GOC:mah”
putrescine biosynthetic process from arginine via N-carbamoylputrescine label “putrescine biosynthetic process from arginine via N-carbamoylputrescine”
putrescine biosynthetic process from arginine via N-carbamoylputrescine SubClassOf putrescine biosynthetic process from arginine

putrescine biosynthetic process from arginine via N-carbamoylputrescine term tracker item “https://github.com/geneontology/go-ontology/issues/31766”^^anyURI
putrescine biosynthetic process from arginine via N-carbamoylputrescine term replaced by putrescine biosynthetic process
putrescine biosynthetic process from arginine via N-carbamoylputrescine definition “OBSOLETE. The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine, via the intermediate N-carbamoylputrescine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in two single enzymatic steps.”
- database_cross_reference “MetaCyc:PWY-43”
- database_cross_reference “GOC:mah”
putrescine biosynthetic process from arginine via N-carbamoylputrescine deprecated true
putrescine biosynthetic process from arginine via N-carbamoylputrescine comment “The reason for obsoletion is that this term represents a GO-CAM.”
putrescine biosynthetic process from arginine via N-carbamoylputrescine label “obsolete putrescine biosynthetic process from arginine via N-carbamoylputrescine”

pyruvate family amino acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of any amino acid that requires pyruvate for its synthesis, e.g. alanine.”
- database_cross_reference “GOC:jl”

pyruvate family amino acid biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/32000”^^anyURI
pyruvate family amino acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of an L-amino acid derived from pyruvate (L-alanine, L-valine, and L-leucine).”
- database_cross_reference “GOC:curators”

regulation of COPII vesicle coating term tracker item “https://github.com/geneontology/go-ontology/issues/31945”^^anyURI
regulation of COPII vesicle coating term replaced by COPII vesicle coating
regulation of COPII vesicle coating definition “OBSOLETE. Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat.”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:ascb_2009”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:jp”
regulation of COPII vesicle coating deprecated true
regulation of COPII vesicle coating comment “This term was obsoleted because the proteins previously annotated to it are part_of the COPII vesicle coating pathway rather than upstream regulators of it. Annotations should be moved to GO:0048208 COPII vesicle coat assembly.”
regulation of COPII vesicle coating label “obsolete regulation of COPII vesicle coating”

regulation of L-dopa biosynthetic process term tracker item “https://github.com/geneontology/go-ontology/issues/31703”^^anyURI
regulation of L-dopa biosynthetic process definition “OBSOLETE. Any process that modulates the frequency, rate or extent of L-dopa biosynthetic process.”
- database_cross_reference “GOC:bf”
- database_cross_reference “GOC:PARL”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “GO_REF:0000058”
regulation of L-dopa biosynthetic process deprecated true
regulation of L-dopa biosynthetic process comment “This term was obsoleted because there is no evidence that this process exists.”
regulation of L-dopa biosynthetic process label “obsolete regulation of L-dopa biosynthetic process”

regulation of butyryl-CoA catabolic process to butanol term tracker item “https://github.com/geneontology/go-ontology/issues/31933”^^anyURI
regulation of butyryl-CoA catabolic process to butanol definition “OBSOLETE. Any process that modulates the frequency, rate or extent of butyryl-CoA catabolic process to butanol.”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “GOC:mengo_curators”
regulation of butyryl-CoA catabolic process to butanol deprecated true
regulation of butyryl-CoA catabolic process to butanol comment “This term was obsoleted because it is an unnecessary grouping term.”
regulation of butyryl-CoA catabolic process to butanol label “obsolete regulation of butyryl-CoA catabolic process to butanol”

regulation of butyryl-CoA catabolic process to butyrate term tracker item “https://github.com/geneontology/go-ontology/issues/31933”^^anyURI
regulation of butyryl-CoA catabolic process to butyrate definition “OBSOLETE. Any process that modulates the frequency, rate or extent of butyryl-CoA catabolic process to butyrate.”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “GOC:mengo_curators”
regulation of butyryl-CoA catabolic process to butyrate deprecated true
regulation of butyryl-CoA catabolic process to butyrate comment “This term was obsoleted because it is an unnecessary grouping term.”
regulation of butyryl-CoA catabolic process to butyrate label “obsolete regulation of butyryl-CoA catabolic process to butyrate”

regulation of methane biosynthetic process from formic acid term tracker item “https://github.com/geneontology/go-ontology/issues/31933”^^anyURI
regulation of methane biosynthetic process from formic acid definition “OBSOLETE. Any process that modulates the frequency, rate or extent of methane biosynthetic process from formic acid.”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “GOC:mengo_curators”
regulation of methane biosynthetic process from formic acid deprecated true
regulation of methane biosynthetic process from formic acid comment “This term was obsoleted because it is an unnecessary grouping term.”
regulation of methane biosynthetic process from formic acid label “obsolete regulation of methane biosynthetic process from formic acid”

regulation of methane biosynthetic process from methanethiol term tracker item “https://github.com/geneontology/go-ontology/issues/31933”^^anyURI
regulation of methane biosynthetic process from methanethiol definition “OBSOLETE. Any process that modulates the frequency, rate or extent of methane biosynthetic process from methanethiol.”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “GOC:mengo_curators”
regulation of methane biosynthetic process from methanethiol deprecated true
regulation of methane biosynthetic process from methanethiol comment “This term was obsoleted because it is an unnecessary grouping term.”
regulation of methane biosynthetic process from methanethiol label “obsolete regulation of methane biosynthetic process from methanethiol”

regulation of methane biosynthetic process from methylamine term tracker item “https://github.com/geneontology/go-ontology/issues/31933”^^anyURI
regulation of methane biosynthetic process from methylamine definition “OBSOLETE. Any process that modulates the frequency, rate or extent of methane biosynthetic process from methylamine.”
- database_cross_reference “GOC:TermGenie”
- database_cross_reference “GOC:mengo_curators”
regulation of methane biosynthetic process from methylamine deprecated true
regulation of methane biosynthetic process from methylamine comment “This term was obsoleted because it is an unnecessary grouping term.”
regulation of methane biosynthetic process from methylamine label “obsolete regulation of methane biosynthetic process from methylamine”

regulation of nitric oxide mediated signal transduction term tracker item “https://github.com/geneontology/go-ontology/issues/26613”^^anyURI
regulation of nitric oxide mediated signal transduction term replaced by regulation of nitric oxide-cGMP mediated signal transduction
regulation of nitric oxide mediated signal transduction definition “OBSOLETE. Any process that modulates the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO).”
- database_cross_reference “GOC:dph”
- database_cross_reference “GOC:tb”
- database_cross_reference “GOC:BHF”
regulation of nitric oxide mediated signal transduction deprecated true
regulation of nitric oxide mediated signal transduction comment “The reason for obsoletion is that this term has been inconsistently used and NO signaling proceeds via cGMP, so the more specific replacement term is preferred.”
regulation of nitric oxide mediated signal transduction label “obsolete regulation of nitric oxide mediated signal transduction”

AnnotationProperty: relatedMatch

retrograde transporter complex, Golgi to ER has_exact_synonym “retrograde transporter complex, Golgi to endoplasmic reticulum”
retrograde transporter complex, Golgi to ER definition “Transporter complex that recognises, binds and returns endoplasmic reticulum (ER) resident proteins that have trafficked to Golgi compartments. Targets proteins lacking the HDEL motif recognised by COPI-coated vesicles.”
- database_cross_reference “GOC:bhm”
- database_cross_reference “PMID:16093310”
retrograde transporter complex, Golgi to ER label “retrograde transporter complex, Golgi to ER”
retrograde transporter complex, Golgi to ER SubClassOf transporter complex

retrograde transporter complex, Golgi to ER term tracker item “https://github.com/geneontology/go-ontology/issues/31935”^^anyURI
retrograde transporter complex, Golgi to ER has_broad_synonym “retrograde transporter complex, Golgi to ER”
retrograde transporter complex, Golgi to ER has_exact_synonym “retrograde cargo receptor complex, Golgi to endoplasmic reticulum”
retrograde transporter complex, Golgi to ER definition “Cargo receptor complex that recognizes, binds and returns endoplasmic reticulum (ER) resident proteins that have trafficked to Golgi compartments. Targets proteins lacking the HDEL motif recognised by COPI-coated vesicles.”
- database_cross_reference “GOC:bhm”
- database_cross_reference “PMID:16093310”
retrograde transporter complex, Golgi to ER label “retrograde cargo receptor complex, Golgi to ER”
retrograde transporter complex, Golgi to ER SubClassOf cargo receptor complex

ricinine nitrilase activity definition “Catalysis of the reaction: ricinine + 2 H2O = 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4+.”
- database_cross_reference “RHEA:22704”

ricinine nitrilase activity definition “Catalysis of the reaction: ricinine + 2 H2O = 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4+.”
- database_cross_reference “RHEA:22704”

serine family amino acid biosynthetic process definition “The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.”
- database_cross_reference “GOC:ai”
serine family amino acid biosynthetic process SubClassOf alpha-amino acid biosynthetic process

serotonin biosynthetic process from L-tryptophan definition “The chemical reactions and pathways resulting in the formation from L-tryptophan of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:30901029”
- database_cross_reference “PMID:35495641”
- database_cross_reference “ISBN:0198506732”
serotonin biosynthetic process from L-tryptophan label “serotonin biosynthetic process from L-tryptophan”
serotonin biosynthetic process from L-tryptophan SubClassOf L-tryptophan metabolic process
serotonin biosynthetic process from L-tryptophan SubClassOf serotonin biosynthetic process

serotonin biosynthetic process from L-tryptophan term replaced by serotonin biosynthetic process
serotonin biosynthetic process from L-tryptophan definition “OBSOLETE. The chemical reactions and pathways resulting in the formation from L-tryptophan of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:30901029”
- database_cross_reference “PMID:35495641”
- database_cross_reference “ISBN:0198506732”
serotonin biosynthetic process from L-tryptophan deprecated true
serotonin biosynthetic process from L-tryptophan comment “The reason for obsoletion is that the term is too specific.”
serotonin biosynthetic process from L-tryptophan label “obsolete serotonin biosynthetic process from L-tryptophan”

serotonin transport definition “The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems.”
- database_cross_reference “GOC:ai”
serotonin transport label “serotonin transport”
serotonin transport SubClassOf monoamine transport
serotonin transport SubClassOf organic hydroxy compound transport

serotonin transport term tracker item “https://github.com/geneontology/go-ontology/issues/31143”^^anyURI
serotonin transport definition “OBSOLETE. The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems.”
- database_cross_reference “GOC:ai”
serotonin transport deprecated true
serotonin transport comment “The reason for obsoletion is that this is an unnecessary grouping term and annotations should be made to more mechanism/location specific terms.”
serotonin transport label “obsolete serotonin transport”

signal sequence binding definition “Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized.”
- database_cross_reference “GOC:ai”
signal sequence binding label “signal sequence binding”
signal sequence binding SubClassOf peptide binding

signal sequence binding term tracker item “https://github.com/geneontology/go-ontology/issues/31419”^^anyURI
signal sequence binding has_narrow_synonym “signal sequence binding”
signal sequence binding definition “Binding to a signal sequence, a short stretch of amino acids found in a protein that acts as a signal for its proper localization in the cell.”
- database_cross_reference “GOC:curators”
signal sequence binding label “signal sequence receptor activity”
signal sequence binding SubClassOf molecular_function

spermine acetylation term tracker item “https://github.com/geneontology/go-ontology/issues/31741”^^anyURI
spermine acetylation consider diamine N-acetyltransferase activity
spermine acetylation consider spermine catabolic process
spermine acetylation definition “OBSOLETE. The modification of spermine by addition of acetyl groups.”
- database_cross_reference “GOC:mlg”
spermine acetylation deprecated true
spermine acetylation comment “The reason for obsoletion is that this term represents a molecular function.”
spermine acetylation label “obsolete spermine acetylation”

succinate-hydroxymethylglutarate CoA-transferase activity definition “Catalysis of the reaction: (S)-3-hydroxy-3-methylglutarate + succinyl-CoA = 3-hydroxy-3-methyl-glutaryl-CoA + succinate.”
- database_cross_reference “MetaCyc:2.8.3.13-RXN”
- database_cross_reference “EC:2.8.3.13”

succinate-hydroxymethylglutarate CoA-transferase activity definition “Catalysis of the reaction: 3-hydroxy-3-methylglutarate + succinyl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + succinate.”
- database_cross_reference “RHEA:12284”

succinyl-CoA:(R)-benzylsuccinate CoA-transferase activity definition “Catalysis of the reaction: (R)-2-benzylsuccinate + succinyl-CoA = (R)-2-benzylsuccinyl-CoA + succinate.”
- database_cross_reference “RHEA:16469”
- database_cross_reference “EC:2.8.3.15”

succinyl-CoA:(R)-benzylsuccinate CoA-transferase activity definition “Catalysis of the reaction: (R)-2-benzylsuccinate + succinyl-CoA = (R)-2-benzylsuccinyl-CoA + succinate.”
- database_cross_reference “RHEA:16469”

succinyl-CoA:(R)-citramalate CoA-transferase activity definition “Catalysis of the reaction: succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA.”
- database_cross_reference “GOC:jl”
- database_cross_reference “PMID:17259315”

succinyl-CoA:(R)-citramalate CoA-transferase activity definition “Catalysis of the reaction: succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA.”
- database_cross_reference “PMID:17259315”
- database_cross_reference “RHEA:38279”

sugar-phosphatase activity definition “Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate.”
- database_cross_reference “MetaCyc:SUGAR-PHOSPHATASE-RXN”
- database_cross_reference “EC:3.1.3.23”

sugar-phosphatase activity definition “Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate.”
- database_cross_reference “EC:3.1.3.23”

sulfate adenylyltransferase (ATP) activity definition “Catalysis of the reaction: ATP + H+ + sulfate = adenosine 5’-phosphosulfate + diphosphate.”
- database_cross_reference “EC:2.7.7.4”

sulfate adenylyltransferase (ATP) activity definition “Catalysis of the reaction: sulfate + ATP + H+ = adenosine 5’-phosphosulfate + diphosphate.”
- database_cross_reference “RHEA:18133”

sulfide oxidation database_cross_reference “MetaCyc:Sulfide-Oxidation”
sulfide oxidation definition “The chemical reactions and pathways resulting in the conversion of sulfide to elemental sulfur in a higher oxidation state, or to sulfite or sulfate.”
- database_cross_reference “MetaCyc:Sulfide-Oxidation”

Class: symbiont-mediated disassembly of host stress granules
symbiont-mediated disassembly of host stress granules term tracker item “https://github.com/geneontology/go-ontology/issues/31751”^^anyURI
symbiont-mediated disassembly of host stress granules created by “pg”
symbiont-mediated disassembly of host stress granules creation date “2026-04-07T12:22:21Z”
symbiont-mediated disassembly of host stress granules has_obo_namespace “biological_process”
symbiont-mediated disassembly of host stress granules id “GO:0140402”
symbiont-mediated disassembly of host stress granules definition “The process in which an organism effects a change that impairs the structure or function of the stress granule of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. Stress granules are dynamic cytoplasmic condensates formed through liquid-liquid phase separation. They act as a critical hub for both cellular stress adaptation and defense against viruses.”
- database_cross_reference “PMID:32353859”
- database_cross_reference “PMID:39345463”
symbiont-mediated disassembly of host stress granules label “symbiont-mediated disassembly of host stress granules”
symbiont-mediated disassembly of host stress granules SubClassOf symbiont-mediated disruption of host cellular anatomical structure

Class: symbiont-mediated suppression of host immunothrombosis
symbiont-mediated suppression of host immunothrombosis term tracker item “https://github.com/geneontology/go-ontology/issues/31936”^^anyURI
symbiont-mediated suppression of host immunothrombosis created by “pg”
symbiont-mediated suppression of host immunothrombosis creation date “2026-05-05T13:07:35Z”
symbiont-mediated suppression of host immunothrombosis has_obo_namespace “biological_process”
symbiont-mediated suppression of host immunothrombosis has_related_synonym “symbiont-mediated suppression of host thrombin-induced platelet aggregation”
symbiont-mediated suppression of host immunothrombosis id “GO:0140422”
symbiont-mediated suppression of host immunothrombosis definition “A process by which a symbiont inhibits or disrupts thrombosis formation induced by host immune cells in response to a pathogenic symbiont. Microbial-associated molecular patterns (MAMPs) are recognized by host signaling receptors, leading to platelet activation. The blood clot formed creates a physical barrier that prevent symbiont dessimination, traps and kills pathogens.”
- database_cross_reference “PMID:42049611”
- database_cross_reference “PMID:24278414”
- database_cross_reference “PMID:40973015”
symbiont-mediated suppression of host immunothrombosis label “symbiont-mediated suppression of host immunothrombosis”
symbiont-mediated suppression of host immunothrombosis SubClassOf symbiont-mediated perturbation of host defense response

synaptic vesicle targeting definition “The process in which synaptic vesicles are directed to specific destination membranes, mediated by molecules at the vesicle membrane and target membrane surfaces.”
- database_cross_reference “GOC:mah”
synaptic vesicle targeting label “synaptic vesicle targeting”
synaptic vesicle targeting SubClassOf vesicle targeting
synaptic vesicle targeting SubClassOf exocytic process
synaptic vesicle targeting SubClassOf part of some synaptic vesicle exocytosis

synaptic vesicle targeting term tracker item “https://github.com/geneontology/go-ontology/issues/31864”^^anyURI
synaptic vesicle targeting term replaced by synaptic vesicle exocytosis
synaptic vesicle targeting definition “OBSOLETE. The process in which synaptic vesicles are directed to specific destination membranes, mediated by molecules at the vesicle membrane and target membrane surfaces.”
- database_cross_reference “GOC:mah”
synaptic vesicle targeting deprecated true
synaptic vesicle targeting comment “This term was made obsolete because the meaning of the term is ambiguous and usage has been inconsistent. The process it intended to describe is encompassed by the parent term synaptic vesicle exocytosis.”
synaptic vesicle targeting label “obsolete synaptic vesicle targeting”

synaptic vesicle tethering involved in synaptic vesicle exocytosis definition “The initial, indirect interaction between a synaptic vesicle membrane and a the preseynaptic membrane active zone. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. This process is distinct from and prior to synaptic vesicle priming and fusion.”
- database_cross_reference “GOC:rn”
synaptic vesicle tethering involved in synaptic vesicle exocytosis label “synaptic vesicle tethering involved in synaptic vesicle exocytosis”
synaptic vesicle tethering involved in synaptic vesicle exocytosis SubClassOf vesicle tethering involved in exocytosis
synaptic vesicle tethering involved in synaptic vesicle exocytosis SubClassOf part of some synaptic vesicle docking

synaptic vesicle tethering involved in synaptic vesicle exocytosis term tracker item “https://github.com/geneontology/go-ontology/issues/31871”^^anyURI
synaptic vesicle tethering involved in synaptic vesicle exocytosis consider synaptic vesicle exocytosis
synaptic vesicle tethering involved in synaptic vesicle exocytosis consider vesicle membrane tethering activity
synaptic vesicle tethering involved in synaptic vesicle exocytosis definition “OBSOLETE. The initial, indirect interaction between a synaptic vesicle membrane and a the preseynaptic membrane active zone. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. This process is distinct from and prior to synaptic vesicle priming and fusion.”
- database_cross_reference “GOC:rn”
synaptic vesicle tethering involved in synaptic vesicle exocytosis deprecated true
synaptic vesicle tethering involved in synaptic vesicle exocytosis comment “This term was obsoleted because it represents a molecular function (vesicle membrane tethering activity) rather than a biological process, and is pre-composed; the same information is better represented as a GO-CAM model. Annotations should be reviewed and reannotated to the new MF term GO:7770062 ‘vesicle membrane tethering activity’, combined with GO:0016079 ‘synaptic vesicle exocytosis’ as appropriate.”
synaptic vesicle tethering involved in synaptic vesicle exocytosis label “obsolete synaptic vesicle tethering involved in synaptic vesicle exocytosis”

tRNA wobble position uridine thiolation definition “The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.”
- database_cross_reference “PMID:16871210”

tRNA wobble position uridine thiolation definition “The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from L-cysteine to position C2 by several steps.”
- database_cross_reference “PMID:16871210”

terephthalate 1,2-dioxygenase activity definition “Catalysis of the reaction: H+ + NADH + O2 + terephthalate = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD+.”
- database_cross_reference “EC:1.14.12.15”
- database_cross_reference “RHEA:10312”

terephthalate 1,2-dioxygenase activity definition “Catalysis of the reaction: terephthalate + NADH + O2 + H+ = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD+.”
- database_cross_reference “RHEA:10312”

toluene dioxygenase activity definition “Catalysis of the reaction: H+ + NADH + O2 + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+.”
- database_cross_reference “EC:1.14.12.11”
- database_cross_reference “RHEA:16737”

toluene dioxygenase activity definition “Catalysis of the reaction: toluene + NADH + O2 + H+ = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+.”
- database_cross_reference “RHEA:16737”

trimethylenediamine catabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31766”^^anyURI
trimethylenediamine catabolic process definition “OBSOLETE. The chemical reactions and pathways resulting in the breakdown of trimethylenediamine.”
- database_cross_reference “UniPathway:UPA00010”
- database_cross_reference “GOC:yaf”
- database_cross_reference “GOC:TermGenie”
trimethylenediamine catabolic process deprecated true
trimethylenediamine catabolic process comment “The reason for obsoletion is that this term was made in error.”
trimethylenediamine catabolic process label “obsolete trimethylenediamine catabolic process”

tubulin folding cofactor complex definition “A multimeric protein complex involved in tubulin alpha-beta-subunit folding assembly consisting of beta-tubulin-TFC-D, alpha-tubulin-TFC-E and TFC-C, through which tubulin subunit association and dimer release occur.”
- database_cross_reference “PMID:12445400”
- database_cross_reference “GOC:vw”
tubulin folding cofactor complex label “tubulin folding cofactor complex”
tubulin folding cofactor complex SubClassOf protein-containing complex

tubulin folding cofactor complex term tracker item “https://github.com/geneontology/go-ontology/issues/31828”^^anyURI
tubulin folding cofactor complex definition “OBSOLETE. A multimeric protein complex involved in tubulin alpha-beta-subunit folding assembly consisting of beta-tubulin-TFC-D, alpha-tubulin-TFC-E and TFC-C, through which tubulin subunit association and dimer release occur.”
- database_cross_reference “PMID:12445400”
- database_cross_reference “GOC:vw”
tubulin folding cofactor complex deprecated true
tubulin folding cofactor complex comment “This term was obsoleted because it was created by mistake; this is a pathway, not a complex.”
tubulin folding cofactor complex label “obsolete tubulin folding cofactor complex”

tyramine transport created by “dragon-ai-agent”
tyramine transport definition “The directed movement of tyramine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Tyramine is a monoamine neurotransmitter occurring predominantly in invertebrates.”
- database_cross_reference “PMID:9870940”
- database_cross_reference “PMID:32305263”
- database_cross_reference “PMID:15849736”
tyramine transport label “tyramine transport”
tyramine transport SubClassOf monoamine transport
tyramine transport SubClassOf organic hydroxy compound transport

tyramine transport definition “OBSOLETE. The directed movement of tyramine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Tyramine is a monoamine neurotransmitter occurring predominantly in invertebrates.”
- database_cross_reference “PMID:9870940”
- database_cross_reference “PMID:32305263”
- database_cross_reference “PMID:15849736”
tyramine transport deprecated true
tyramine transport comment “The reason for obsoletion is that this is an unnecessary grouping term and annotations should be made to more mechanism/location specific terms.”
tyramine transport label “obsolete tyramine transport”

tyrosine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI
tyrosine metabolic process consider L-tyrosine biosynthetic process
tyrosine metabolic process consider L-tyrosine catabolic process
tyrosine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.”
- database_cross_reference “GOC:curators”
tyrosine metabolic process deprecated true
tyrosine metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
tyrosine metabolic process label “obsolete tyrosine metabolic process”

unfolded protein binding term tracker item “https://github.com/geneontology/go-ontology/issues/30962”^^anyURI
unfolded protein binding consider protein folding chaperone
unfolded protein binding consider unfolded protein holdase activity
unfolded protein binding definition “OBSOLETE. Binding to an unfolded protein.”
- database_cross_reference “GOC:ai”
unfolded protein binding deprecated true
unfolded protein binding comment “The reason for obsoletion is that this binding term should be replaced by an activity term such as protein folding chaperone (GO:0044183) or unfolded protein holdase activity (GO:0140309).”
unfolded protein binding label “obsolete unfolded protein binding”

vacuole-ER tethering term tracker item “https://github.com/geneontology/go-ontology/issues/31874”^^anyURI
vacuole-ER tethering consider endoplasmic reticulum-vacuole tether activity
vacuole-ER tethering definition “OBSOLETE. The attachment of a lytic vacuole to the endoplasmic reticulum, which may facilitate exchange of metabolites between the organelles.”
- database_cross_reference “PMID:26283797”
vacuole-ER tethering deprecated true
vacuole-ER tethering comment “The reason for obsoletion is that this term represents a molecular function, not a biological process. The molecular function is captured by GO:7770066 endoplasmic reticulum-vacuole tether activity.”
vacuole-ER tethering label “obsolete vacuole-ER tethering”

vacuole-mitochondria membrane tethering definition “The attachment of a mitochondrial membrane to a vacuolar membrane via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles.”
- database_cross_reference “PMID:27875684”
vacuole-mitochondria membrane tethering label “vacuole-mitochondria membrane tethering”
vacuole-mitochondria membrane tethering SubClassOf organelle localization by membrane tethering

vacuole-mitochondria membrane tethering term tracker item “https://github.com/geneontology/go-ontology/issues/31876”^^anyURI
vacuole-mitochondria membrane tethering definition “OBSOLETE. The attachment of a mitochondrial membrane to a vacuolar membrane via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles.”
- database_cross_reference “PMID:27875684”
vacuole-mitochondria membrane tethering deprecated true
vacuole-mitochondria membrane tethering comment “The reason for obsoletion is that this term was added in error.”
vacuole-mitochondria membrane tethering label “obsolete vacuole-mitochondria membrane tethering”

valine metabolic process term tracker item “https://github.com/geneontology/go-ontology/issues/31172”^^anyURI
valine metabolic process consider L-valine catabolic process
valine metabolic process consider L-valine biosynthetic process
valine metabolic process definition “OBSOLETE. The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid.”
- database_cross_reference “GOC:ai”
valine metabolic process deprecated true
valine metabolic process comment “This term was obsoleted because it is an unnecessary grouping term.”
valine metabolic process label “obsolete valine metabolic process”

vesicle coating has_broad_synonym “vesicle coat assembly”
vesicle coating label “vesicle coating”

vesicle coating has_exact_synonym “vesicle coating”
vesicle coating label “vesicle coat assembly”

Class: vesicle docking activity
vesicle docking activity term tracker item “https://github.com/geneontology/go-ontology/issues/31880”^^anyURI
vesicle docking activity created by “rynl”
vesicle docking activity creation date “2026-04-17T21:35:33Z”
vesicle docking activity has_obo_namespace “molecular_function”
vesicle docking activity id “GO:0160321”
vesicle docking activity definition “The binding activity of a protein that directly mediates the stable attachment of a transport vesicle to a target membrane, bringing the two membranes into close apposition.”
- database_cross_reference “PMID:28237810”
vesicle docking activity comment “Vesicle docking activity succeeds vesicle tethering activity and precedes fusogenic activity in the vesicle membrane fusion pathway.”
vesicle docking activity label “vesicle docking activity”
vesicle docking activity SubClassOf membrane-membrane adaptor activity

vesicle targeting, trans-Golgi to periciliary membrane compartment definition “The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces.”
- database_cross_reference “PMID:26485645”
- database_cross_reference “GOC:cilia”
- database_cross_reference “PMID:24814148”
- database_cross_reference “PMID:20106869”
- database_cross_reference “PMID:23351793”
vesicle targeting, trans-Golgi to periciliary membrane compartment label “vesicle targeting, trans-Golgi to periciliary membrane compartment”
vesicle targeting, trans-Golgi to periciliary membrane compartment SubClassOf vesicle targeting, to, from or within Golgi

vesicle targeting, trans-Golgi to periciliary membrane compartment term tracker item “https://github.com/geneontology/go-ontology/issues/31865”^^anyURI
vesicle targeting, trans-Golgi to periciliary membrane compartment has_related_synonym “vesicle targeting, trans-Golgi to periciliary membrane compartment”
vesicle targeting, trans-Golgi to periciliary membrane compartment definition “The directed movement of substances from the trans-Golgi network to the periciliary membrane compartment, the specialized region of the plasma membrane surrounding the base of the cilium including the ciliary pocket, via vesicle-mediated transport.”
- database_cross_reference “PMID:26485645”
- database_cross_reference “PMID:24814148”
- database_cross_reference “PMID:20106869”
- database_cross_reference “PMID:23351793”
vesicle targeting, trans-Golgi to periciliary membrane compartment label “trans-Golgi to periciliary membrane compartment transport”
vesicle targeting, trans-Golgi to periciliary membrane compartment SubClassOf Golgi to plasma membrane transport

vesicle tethering definition “The initial, indirect interaction between a vesicle membrane and a membrane to which it is targeted for fusion. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to interaction between factors involved in fusion.”
- database_cross_reference “PMID:27243008”
vesicle tethering label “vesicle tethering”
vesicle tethering SubClassOf cellular component organization
vesicle tethering SubClassOf part of some vesicle targeting

vesicle tethering term tracker item “https://github.com/geneontology/go-ontology/issues/31881”^^anyURI
vesicle tethering consider vesicle membrane tethering activity
vesicle tethering definition “OBSOLETE. The initial, indirect interaction between a vesicle membrane and a membrane to which it is targeted for fusion. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to interaction between factors involved in fusion.”
- database_cross_reference “PMID:27243008”
vesicle tethering deprecated true
vesicle tethering comment “This term was obsoleted because it represents a molecular function (vesicle membrane tethering activity) rather than a biological process. Annotations should be reviewed and reannotated to the new MF term GO:7770062 ‘vesicle membrane tethering activity’, and where appropriate combined with the relevant vesicle-mediated transport / exocytosis process term in a GO-CAM model.”
vesicle tethering label “obsolete vesicle tethering”

vesicle tethering involved in exocytosis has_narrow_synonym “vesicle tethering to plasma membrane”
vesicle tethering involved in exocytosis definition “The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion.”
- database_cross_reference “PMID:22420621”
- database_cross_reference “PMID:10559876”
- database_cross_reference “PMID:17488620”
- database_cross_reference “PMID:27243008”
- database_cross_reference “PMID:17052174”
- database_cross_reference “GOC:rn”
vesicle tethering involved in exocytosis label “vesicle tethering involved in exocytosis”
vesicle tethering involved in exocytosis EquivalentTo vesicle tethering and (part of some exocytosis)
vesicle tethering involved in exocytosis SubClassOf vesicle tethering
vesicle tethering involved in exocytosis SubClassOf exocytic process

vesicle tethering involved in exocytosis term tracker item “https://github.com/geneontology/go-ontology/issues/31872”^^anyURI
vesicle tethering involved in exocytosis consider exocytosis
vesicle tethering involved in exocytosis consider vesicle membrane tethering activity
vesicle tethering involved in exocytosis definition “OBSOLETE. The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion.”
- database_cross_reference “PMID:22420621”
- database_cross_reference “PMID:10559876”
- database_cross_reference “PMID:17488620”
- database_cross_reference “PMID:27243008”
- database_cross_reference “PMID:17052174”
- database_cross_reference “GOC:rn”
vesicle tethering involved in exocytosis deprecated true
vesicle tethering involved in exocytosis comment “This term was obsoleted because it represents a molecular function (vesicle membrane tethering activity) rather than a biological process, and is pre-composed; the same information is better represented as a GO-CAM model. Annotations should be reviewed and reannotated to the new MF term GO:7770062 ‘vesicle membrane tethering activity’, combined with GO:0006887 ‘exocytosis’ or a descendant as appropriate.”
vesicle tethering involved in exocytosis label “obsolete vesicle tethering involved in exocytosis”

vesicle tethering to Golgi definition “The initial, indirect interaction between a transport vesicle membrane and the membrane of the Golgi. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion.”
- database_cross_reference “PMID:27243008”
vesicle tethering to Golgi label “vesicle tethering to Golgi”
vesicle tethering to Golgi SubClassOf vesicle tethering

vesicle tethering to Golgi term tracker item “https://github.com/geneontology/go-ontology/issues/31872”^^anyURI
vesicle tethering to Golgi consider vesicle membrane tethering activity
vesicle tethering to Golgi definition “OBSOLETE. The initial, indirect interaction between a transport vesicle membrane and the membrane of the Golgi. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion.”
- database_cross_reference “PMID:27243008”
vesicle tethering to Golgi deprecated true
vesicle tethering to Golgi comment “This term was obsoleted because it represents a molecular function rather than a biological process, and is pre-composed; the same information is better represented as a GO-CAM model. Annotations should be reviewed and reannotated to GO:7770062 ‘vesicle membrane tethering activity’, combined with the appropriate vesicle transport pathway BP term as part of a GO-CAM model.”
vesicle tethering to Golgi label “obsolete vesicle tethering to Golgi”

vesicle tethering to endoplasmic reticulum definition “The initial, indirect interaction between a transport vesicle membrane and the membrane of the endoplasmic reticulum. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion.”
- database_cross_reference “PMID:27243008”
vesicle tethering to endoplasmic reticulum label “vesicle tethering to endoplasmic reticulum”
vesicle tethering to endoplasmic reticulum SubClassOf vesicle tethering

vesicle tethering to endoplasmic reticulum term tracker item “https://github.com/geneontology/go-ontology/issues/31868”^^anyURI
vesicle tethering to endoplasmic reticulum consider vesicle membrane tethering activity
vesicle tethering to endoplasmic reticulum definition “OBSOLETE. The initial, indirect interaction between a transport vesicle membrane and the membrane of the endoplasmic reticulum. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion.”
- database_cross_reference “PMID:27243008”
vesicle tethering to endoplasmic reticulum deprecated true
vesicle tethering to endoplasmic reticulum comment “This term was obsoleted because it represents a molecular function rather than a biological process. Annotations should be reviewed; the VAP-related proteins previously annotated here are lipid transfer/adaptor proteins rather than vesicle tethers, and other types of membrane adaptor terms may be more appropriate. Where the activity is genuinely vesicle tethering, reannotate to GO:7770062 ‘vesicle membrane tethering activity’.”
vesicle tethering to endoplasmic reticulum label “obsolete vesicle tethering to endoplasmic reticulum”

vitamin D3 25-hydroxylase activity label “vitamin D3 25-hydroxylase activity”

This site is open source. Improve this page.

go-ontology

Ontology comparison

Left

Right

Ontology imports

Ontology annotations

Removed

Added

‘de novo’ NAD+ biosynthetic process from L-tryptophan http://purl.obolibrary.org/obo/GO_0034354

Removed

Added

(+)-abscisic acid 8’-hydroxylase activity http://purl.obolibrary.org/obo/GO_0010295

Removed

Added

(2E)-enoyl-CoA hydratase activity http://purl.obolibrary.org/obo/GO_0080023

Added

(3R)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity http://purl.obolibrary.org/obo/GO_0106386

Added

(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity http://purl.obolibrary.org/obo/GO_0003857

Added

(R)-2-hydroxyisocaproate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0043713

Removed

Added

(R)-sulfopropanediol 2-dehydrogenase activity http://purl.obolibrary.org/obo/GO_0102157

Removed

Added

1,2-dehydro-N-acetyldopamine biosynthetic process http://purl.obolibrary.org/obo/GO_0120577

Added

1,2-dehydro-N-beta-alanyldopamine biosynthetic process http://purl.obolibrary.org/obo/GO_0120576

Added

1,2-dihydroxynaphthalene dioxygenase activity http://purl.obolibrary.org/obo/GO_0018554

Removed

Added

1,8-cineole 2-exo-monooxygenase activity http://purl.obolibrary.org/obo/GO_0102320

Removed

Added

1,8-cineole synthase activity http://purl.obolibrary.org/obo/GO_0102313

Removed

Added

1-acylglycerol-3-phosphate O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0003841

Added

1-acylglycerophosphocholine O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0047184

Removed

Added

1-acylglycerophosphoethanolamine O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0106262

Removed

Added

1-acylglycerophosphoserine O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0106263

Removed

Added

1-alkenylglycerophosphoethanolamine O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0047166

Removed

Added

1-alkyl-2-acetylglycerol O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0047167

Removed

Added

1-alkylglycerophosphocholine O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0047191

Removed

Added

1-aminocyclopropane-1-carboxylate catabolic process http://purl.obolibrary.org/obo/GO_0042217

Removed

Added

11-oxo-beta-amyrin 30-oxidase activity http://purl.obolibrary.org/obo/GO_0102375

Removed

Added

2,4-dienoyl-CoA reductase (NADPH) activity http://purl.obolibrary.org/obo/GO_0008670

Added

2,5-dioxovalerate dehydrogenase (NAD+) activity http://purl.obolibrary.org/obo/GO_0044104

Removed

Added

2,5-dioxovalerate dehydrogenase (NADP+) activity http://purl.obolibrary.org/obo/GO_0047533

Removed

Added

2-(omega-methylthio)alkylmalate dehydratase activity http://purl.obolibrary.org/obo/GO_0120528

Added

2-acylglycerol O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0003846

Added

2-acylglycerol-3-phosphate O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0047144

Removed

2-acylglycerophosphocholine O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0047190

‘de novo’ NAD+ biosynthetic process from L-tryptophan `http://purl.obolibrary.org/obo/GO_0034354`

(+)-abscisic acid 8’-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0010295`

(2E)-enoyl-CoA hydratase activity `http://purl.obolibrary.org/obo/GO_0080023`

(3R)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0106386`

(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0003857`

(R)-2-hydroxyisocaproate dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0043713`

(R)-sulfopropanediol 2-dehydrogenase activity `http://purl.obolibrary.org/obo/GO_0102157`

1,2-dehydro-N-acetyldopamine biosynthetic process `http://purl.obolibrary.org/obo/GO_0120577`

1,2-dehydro-N-beta-alanyldopamine biosynthetic process `http://purl.obolibrary.org/obo/GO_0120576`

1,2-dihydroxynaphthalene dioxygenase activity `http://purl.obolibrary.org/obo/GO_0018554`

1,8-cineole 2-exo-monooxygenase activity `http://purl.obolibrary.org/obo/GO_0102320`

1,8-cineole synthase activity `http://purl.obolibrary.org/obo/GO_0102313`

1-acylglycerol-3-phosphate O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0003841`

1-acylglycerophosphocholine O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0047184`

1-acylglycerophosphoethanolamine O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0106262`

1-acylglycerophosphoserine O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0106263`

1-alkenylglycerophosphoethanolamine O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0047166`

1-alkyl-2-acetylglycerol O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0047167`

1-alkylglycerophosphocholine O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0047191`

1-aminocyclopropane-1-carboxylate catabolic process `http://purl.obolibrary.org/obo/GO_0042217`

11-oxo-beta-amyrin 30-oxidase activity `http://purl.obolibrary.org/obo/GO_0102375`

2,4-dienoyl-CoA reductase (NADPH) activity `http://purl.obolibrary.org/obo/GO_0008670`

2,5-dioxovalerate dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0044104`

2,5-dioxovalerate dehydrogenase (NADP+) activity `http://purl.obolibrary.org/obo/GO_0047533`

2-(omega-methylthio)alkylmalate dehydratase activity `http://purl.obolibrary.org/obo/GO_0120528`

2-acylglycerol O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0003846`

2-acylglycerol-3-phosphate O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0047144`

2-acylglycerophosphocholine O-acyltransferase activity `http://purl.obolibrary.org/obo/GO_0047190`

2-aminobenzenesulfonate 2,3-dioxygenase activity `http://purl.obolibrary.org/obo/GO_0018627`

2-aminobenzenesulfonate catabolic process `http://purl.obolibrary.org/obo/GO_0046230`

2-dehydropantolactone reductase activity `http://purl.obolibrary.org/obo/GO_0036441`

2-hydroxyacyl-CoA lyase activity `http://purl.obolibrary.org/obo/GO_0106359`

2-hydroxyisocaproate CoA-transferase activity `http://purl.obolibrary.org/obo/GO_0043712`

2-hydroxyquinoline 5,6-dioxygenase activity `http://purl.obolibrary.org/obo/GO_0018629`

2-keto-3-deoxygluconate:proton symporter activity `http://purl.obolibrary.org/obo/GO_0015649`

24-methylenelophenol methyl oxidase activity `http://purl.obolibrary.org/obo/GO_0102177`

3’-phosphoadenosine 5’-phosphosulfate transport `http://purl.obolibrary.org/obo/GO_0046963`

3,9-dihydroxypterocarpan 6a-monooxygenase activity `http://purl.obolibrary.org/obo/GO_0047082`

3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] activity `http://purl.obolibrary.org/obo/GO_0140169`

3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity `http://purl.obolibrary.org/obo/GO_0003854`

3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity `http://purl.obolibrary.org/obo/GO_0102175`

3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity `http://purl.obolibrary.org/obo/GO_0000252`

3-butenylglucosinolate 2-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0062131`

3-chlorobenzoate-3,4-oxygenase activity `http://purl.obolibrary.org/obo/GO_0102045`

3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity `http://purl.obolibrary.org/obo/GO_0017060`

3-hydroxy-2-methylpyridinecarboxylate dioxygenase activity `http://purl.obolibrary.org/obo/GO_0047081`

3-hydroxyacyl-CoA dehydratase activity `http://purl.obolibrary.org/obo/GO_0018812`

3-oxoadipate CoA-transferase activity `http://purl.obolibrary.org/obo/GO_0047569`

3-phenylpropionate dioxygenase activity `http://purl.obolibrary.org/obo/GO_0008695`

3-sulfino-L-alanine: proton, glutamate antiporter activity `http://purl.obolibrary.org/obo/GO_0000514`

3alpha-hydroxy-ent-sandaracopimardiene 7-beta-monooxygenase activity `http://purl.obolibrary.org/obo/GO_0102598`

3alpha-hydroxy-ent-sandaracopimardiene 9-beta-monooxygenase activity `http://purl.obolibrary.org/obo/GO_0102597`

4’-methoxyisoflavone 2’-hydroxylase activity `http://purl.obolibrary.org/obo/GO_0047957`

4-(trimethylammonio)butanoate transport `http://purl.obolibrary.org/obo/GO_1900751`

4-O-methyl-glucuronoyl methylesterase activity `http://purl.obolibrary.org/obo/GO_0052797`